Best TWAS P=5.28e-09 · Best GWAS P=3.57e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LIME1 | 0.04 | 0.00 | bslmm | 439 | 0.01 | 3.3e-02 | 2.1 | -5.3 | 9.2e-08 | 0.57 | 0.02 | 0.93 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | RGS19 | 0.37 | 0.28 | lasso | 8 | 0.29 | 3.2e-22 | 4.9 | -5.4 | 5.4e-08 | 0.00 | 0.43 | 0.57 | FALSE |
| 3 | GTEx | Pancreas | OPRL1 | 0.39 | 0.27 | lasso | 5 | 0.32 | 6.9e-14 | -4.0 | -5.2 | 2.0e-07 | -0.02 | 0.66 | 0.33 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | RGS19 | 0.51 | 0.28 | enet | 28 | 0.32 | 4.3e-18 | -4.0 | -5.4 | 6.7e-08 | -0.05 | 0.93 | 0.06 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | OPRL1 | 0.14 | 0.10 | lasso | 6 | 0.11 | 4.4e-09 | 4.9 | -5.2 | 2.2e-07 | -0.01 | 0.52 | 0.48 | FALSE |
| 6 | GTEx | Whole Blood | OPRL1 | 0.09 | 0.06 | enet | 8 | 0.07 | 4.3e-07 | 4.4 | 5.4 | 5.8e-08 | 0.00 | 0.62 | 0.37 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | C20orf201 | 0.10 | 0.09 | enet | 9 | 0.10 | 9.9e-13 | -4.9 | 5.3 | 1.1e-07 | 0.04 | 0.45 | 0.54 | FALSE |
| 8 | YFS | Blood | OPRL1 | 0.07 | 0.07 | lasso | 5 | 0.09 | 5.0e-27 | -4.0 | 5.5 | 4.4e-08 | 0.02 | 0.70 | 0.29 | TRUE |
| 9 | YFS | Blood | SLC2A4RG | 0.03 | 0.02 | lasso | 11 | 0.02 | 4.2e-08 | -5.8 | -5.8 | 5.3e-09 | 0.96 | 0.00 | 1.00 | TRUE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIME1 | 0.04 | 0.03 | lasso | 3 | 0.02 | 7.2e-04 | -5.8 | -5.8 | 8.2e-09 | 0.99 | 0.00 | 0.96 | FALSE |