Best TWAS P=2.1e-10 · Best GWAS P=4.2e-09 conditioned to 0.252
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | AC006547.14 | 0.09 | 0.00 | lasso | 4 | 0.00 | 6.9e-01 | -4.6 | 6.4 | 2.1e-10 | 0.44 | 0.04 | 0.29 | TRUE |
2 | GTEx | Brain Cerebellum | ZDHHC8 | 0.38 | 0.05 | lasso | 10 | 0.04 | 3.2e-02 | 5.1 | -5.1 | 2.9e-07 | -0.30 | 0.03 | 0.81 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | ARVCF | 0.25 | 0.10 | enet | 23 | 0.16 | 4.3e-12 | 5.3 | 5.4 | 7.9e-08 | 0.85 | 0.02 | 0.98 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | ZDHHC8 | 0.18 | 0.07 | enet | 26 | 0.14 | 8.9e-11 | 5.1 | 6.2 | 4.9e-10 | 0.47 | 0.05 | 0.95 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | AC006547.15 | 0.11 | 0.00 | enet | 23 | 0.00 | 3.8e-01 | -2.6 | 5.6 | 1.7e-08 | 0.70 | 0.03 | 0.61 | TRUE |
6 | GTEx | Thyroid | ARVCF | 0.25 | 0.09 | enet | 39 | 0.20 | 7.5e-15 | -4.7 | -5.4 | 6.0e-08 | -0.48 | 0.33 | 0.66 | FALSE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZDHHC8 | 0.05 | 0.02 | blup | 73 | 0.04 | 2.6e-03 | 3.5 | 5.2 | 2.3e-07 | 0.31 | 0.04 | 0.59 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ARVCF | 0.04 | 0.00 | blup | 116 | 0.00 | 1.8e-01 | -4.5 | 5.6 | 2.8e-08 | 0.59 | 0.02 | 0.38 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARVCF | 0.03 | 0.01 | blup | 116 | 0.01 | 1.1e-02 | 4.4 | 5.9 | 3.4e-09 | 0.61 | 0.02 | 0.35 | FALSE |
10 | The Cancer Genome Atlas | Thyroid Carcinoma | C22orf25 | 0.10 | 0.12 | lasso | 4 | 0.12 | 3.0e-11 | 5.2 | 5.3 | 1.2e-07 | 0.33 | 0.05 | 0.94 | FALSE |