Best TWAS P=7.47e-10 · Best GWAS P=1.21e-11 conditioned to 0.00112
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CDC42BPA | 0.10 | 0.05 | lasso | 5 | 0.02 | 3.6e-03 | 4.6 | -5.8 | 5.1e-09 | 0.65 | 0.42 | 0.49 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | PSEN2 | 0.36 | 0.37 | enet | 24 | 0.40 | 1.1e-31 | -4.6 | 5.2 | 2.1e-07 | -0.36 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | ADCK3 | 0.23 | 0.12 | lasso | 9 | 0.09 | 3.6e-04 | -4.6 | -5.1 | 3.0e-07 | 0.35 | 0.46 | 0.05 | FALSE |
| 4 | NTR | Blood | ADCK3 | 0.06 | 0.08 | enet | 9 | 0.08 | 2.5e-23 | 5.6 | 5.4 | 5.4e-08 | -0.45 | 0.82 | 0.18 | TRUE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSEN2 | 0.14 | 0.06 | lasso | 4 | 0.07 | 5.4e-05 | -5.9 | 6.2 | 7.5e-10 | -0.42 | 0.00 | 1.00 | TRUE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PSEN2 | 0.02 | 0.02 | blup | 51 | 0.02 | 1.6e-03 | -4.8 | 5.6 | 2.6e-08 | -0.39 | 0.02 | 0.74 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CABC1 | 0.08 | 0.02 | enet | 6 | 0.05 | 6.6e-06 | -5.9 | -6.0 | 2.5e-09 | 0.54 | 0.46 | 0.32 | FALSE |