Best TWAS P=3.11e-13 · Best GWAS P=2.72e-10 conditioned to 1.84e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | XPC | 0.11 | 0.04 | lasso | 6 | 0.04 | 3.2e-04 | 5.3 | -5.4 | 8.0e-08 | -0.01 | 0.02 | 0.94 | FALSE |
| 2 | GTEx | Esophagus Muscularis | CHCHD4 | 0.10 | 0.08 | lasso | 3 | 0.07 | 4.1e-05 | 5.3 | 5.8 | 6.9e-09 | 0.03 | 0.06 | 0.92 | FALSE |
| 3 | GTEx | Heart Left Ventricle | CHCHD4 | 0.14 | 0.11 | enet | 16 | 0.11 | 1.5e-06 | 5.3 | 7.3 | 3.1e-13 | 0.04 | 0.05 | 0.94 | TRUE |
| 4 | GTEx | Muscle Skeletal | CHCHD4 | 0.10 | 0.11 | lasso | 2 | 0.10 | 6.6e-10 | 5.3 | 5.3 | 1.4e-07 | -0.01 | 0.42 | 0.58 | FALSE |
| 5 | GTEx | Muscle Skeletal | LSM3 | 0.09 | 0.02 | enet | 9 | 0.02 | 7.8e-03 | 5.8 | -5.4 | 7.4e-08 | -0.04 | 0.06 | 0.82 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | CHCHD4 | 0.12 | 0.11 | lasso | 8 | 0.10 | 2.2e-12 | 5.3 | 5.3 | 1.4e-07 | -0.01 | 0.40 | 0.60 | FALSE |