Best TWAS P=4.38e-11 · Best GWAS P=3.58e-17 conditioned to 1.08e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells EBV-transformed lymphocytes | PPARG | 0.23 | 0.09 | lasso | 12 | 0.07 | 2.1e-03 | 4.3 | 5.5 | 2.9e-08 | 0.75 | 0.10 | 0.78 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | HRH1 | 0.20 | 0.00 | lasso | 3 | 0.01 | 1.1e-01 | -7.2 | 6.6 | 4.4e-11 | -0.01 | 0.01 | 0.91 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | ATG7 | 0.26 | 0.10 | enet | 13 | 0.17 | 6.8e-13 | -4.6 | 5.3 | 1.1e-07 | -0.02 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Esophagus Mucosa | ATG7 | 0.12 | 0.04 | enet | 10 | 0.05 | 2.2e-04 | -5.8 | 5.2 | 1.7e-07 | 0.06 | 0.56 | 0.07 | TRUE |
| 5 | GTEx | Heart Left Ventricle | PPARG | 0.25 | 0.07 | enet | 36 | 0.10 | 5.1e-06 | 8.2 | 5.9 | 4.3e-09 | 0.67 | 0.02 | 0.98 | TRUE |
| 6 | GTEx | Nerve Tibial | ATG7 | 0.11 | 0.04 | lasso | 6 | 0.04 | 8.9e-04 | -4.5 | 5.7 | 9.7e-09 | -0.01 | 0.29 | 0.06 | FALSE |
| 7 | GTEx | Thyroid | ATG7 | 0.11 | 0.02 | lasso | 3 | 0.02 | 1.1e-02 | -5.8 | 5.3 | 1.4e-07 | 0.00 | 0.17 | 0.23 | FALSE |
| 8 | YFS | Blood | VGLL4 | 0.05 | 0.01 | blup | 507 | 0.02 | 4.0e-08 | -5.4 | -5.2 | 1.8e-07 | -0.03 | 0.93 | 0.03 | FALSE |