Best TWAS P=2.9e-11 · Best GWAS P=1.88e-12 conditioned to 0.00576
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | PABPC4 | 0.20 | 0.09 | lasso | 8 | 0.06 | 3.0e-03 | -4.13 | 5.8 | 9.1e-09 | 0.22 | 0.25 | 0.06 | FALSE |
| 2 | GTEx | Adrenal Gland | RP11-69E11.4 | 0.11 | 0.05 | lasso | 3 | 0.00 | 2.4e-01 | -4.74 | -5.6 | 2.4e-08 | -0.14 | 0.11 | 0.06 | FALSE |
| 3 | GTEx | Adrenal Gland | PPIEL | 0.29 | 0.01 | lasso | 3 | 0.00 | 2.9e-01 | 4.37 | -6.2 | 5.4e-10 | -0.73 | 0.03 | 0.30 | TRUE |
| 4 | GTEx | Breast Mammary Tissue (Female) | PABPC4 | 0.10 | 0.00 | enet | 9 | 0.01 | 1.5e-01 | -6.07 | 6.0 | 2.7e-09 | 0.03 | 0.06 | 0.07 | FALSE |
| 5 | GTEx | Esophagus Mucosa | PPIEL | 0.11 | 0.02 | lasso | 3 | 0.02 | 9.4e-03 | -4.90 | -5.4 | 8.2e-08 | -0.06 | 0.29 | 0.08 | FALSE |
| 6 | GTEx | Ovary | RP11-69E11.4 | 0.25 | 0.05 | enet | 11 | 0.03 | 6.7e-02 | -5.82 | -6.4 | 1.6e-10 | 0.08 | 0.08 | 0.11 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | RP11-69E11.4 | 0.13 | 0.12 | lasso | 6 | 0.15 | 1.3e-12 | -5.14 | -5.1 | 2.7e-07 | -0.04 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Spleen | RP11-69E11.4 | 0.25 | 0.12 | lasso | 4 | 0.15 | 9.3e-05 | -4.51 | -5.2 | 1.9e-07 | -0.03 | 0.43 | 0.05 | FALSE |
| 9 | NTR | Blood | KIAA0754 | 0.03 | 0.00 | bslmm | 366 | 0.01 | 1.6e-03 | 0.77 | -6.7 | 2.9e-11 | -0.34 | 0.36 | 0.05 | TRUE |
| 10 | NTR | Blood | PABPC4 | 0.01 | 0.00 | blup | 383 | 0.00 | 2.8e-02 | -4.13 | 5.7 | 1.4e-08 | 0.23 | 0.09 | 0.04 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BMP8A | 0.04 | 0.03 | blup | 48 | 0.04 | 3.5e-05 | -4.51 | -6.2 | 6.6e-10 | -0.13 | 0.54 | 0.04 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BMP8A | 0.05 | 0.01 | blup | 48 | 0.04 | 6.8e-05 | -5.61 | -6.0 | 2.5e-09 | -0.38 | 0.17 | 0.08 | FALSE |
| 13 | The Cancer Genome Atlas | Thyroid Carcinoma | PABPC4 | 0.09 | 0.07 | enet | 5 | 0.08 | 4.1e-08 | -4.13 | 6.0 | 2.6e-09 | 0.28 | 0.43 | 0.52 | FALSE |