Best TWAS P=1.33e-12 · Best GWAS P=3.25e-14 conditioned to 3.48e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | OGN | 0.04 | 0.04 | lasso | 4 | 0.04 | 2.3e-05 | -4.61 | -5.3 | 1.4e-07 | -0.01 | 0.11 | 0.87 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | PHF2 | 0.42 | 0.00 | enet | 33 | 0.04 | 2.4e-02 | -0.16 | -5.6 | 2.6e-08 | -0.25 | 0.10 | 0.06 | TRUE |
3 | GTEx | Brain Cerebellum | BICD2 | 0.23 | 0.06 | enet | 21 | 0.17 | 8.5e-06 | 5.53 | 5.5 | 3.6e-08 | 0.09 | 0.08 | 0.24 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | OGN | 0.03 | 0.03 | lasso | 2 | 0.01 | 3.2e-02 | -5.53 | -5.5 | 3.2e-08 | 0.05 | 0.09 | 0.86 | FALSE |
5 | GTEx | Esophagus Muscularis | BICD2 | 0.09 | 0.02 | enet | 26 | 0.07 | 5.0e-05 | 4.09 | 5.5 | 3.1e-08 | 0.11 | 0.09 | 0.59 | TRUE |
6 | GTEx | Heart Left Ventricle | ECM2 | 0.07 | 0.05 | lasso | 3 | 0.02 | 3.1e-02 | 5.49 | 5.8 | 7.7e-09 | -0.01 | 0.08 | 0.71 | FALSE |
7 | GTEx | Liver | ECM2 | 0.16 | 0.18 | enet | 8 | 0.18 | 7.4e-06 | -5.64 | 5.5 | 3.5e-08 | -0.07 | 0.07 | 0.92 | FALSE |
8 | GTEx | Nerve Tibial | OGN | 0.08 | 0.14 | lasso | 9 | 0.12 | 6.3e-09 | -5.13 | -5.4 | 7.0e-08 | 0.09 | 0.12 | 0.88 | FALSE |
9 | GTEx | Pituitary | IPPK | 0.16 | 0.07 | lasso | 4 | 0.07 | 8.5e-03 | -5.11 | -6.1 | 1.3e-09 | 0.10 | 0.08 | 0.64 | TRUE |
10 | GTEx | Skin Sun Exposed Lower leg | CENPP | 0.20 | 0.06 | lasso | 9 | 0.14 | 2.9e-11 | 5.09 | -5.5 | 4.0e-08 | -0.02 | 0.39 | 0.61 | FALSE |
11 | GTEx | Small Intestine Terminal Ileum | CENPP | 0.29 | 0.11 | enet | 11 | 0.10 | 2.9e-03 | -5.14 | -6.0 | 2.4e-09 | 0.02 | 0.10 | 0.68 | FALSE |
12 | NTR | Blood | IPPK | 0.02 | 0.01 | bslmm | 416 | 0.01 | 9.9e-06 | -5.53 | -5.2 | 1.7e-07 | 0.07 | 0.07 | 0.93 | FALSE |
13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | CENPP | 0.08 | 0.00 | lasso | 6 | 0.00 | 1.3e-01 | -3.64 | -5.2 | 2.2e-07 | -0.04 | 0.04 | 0.33 | FALSE |
14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CENPP | 0.07 | 0.03 | lasso | 5 | 0.06 | 2.1e-11 | 5.09 | -6.4 | 1.8e-10 | 0.02 | 0.06 | 0.94 | TRUE |
15 | The Cancer Genome Atlas | Colon Adenocarcinoma | CENPP | 0.21 | 0.04 | enet | 16 | 0.10 | 1.9e-06 | 5.09 | -6.1 | 8.1e-10 | 0.11 | 0.07 | 0.78 | FALSE |
16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CENPP | 0.06 | 0.02 | blup | 160 | 0.04 | 6.3e-05 | 5.09 | -6.4 | 1.8e-10 | 0.03 | 0.07 | 0.87 | FALSE |
17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | OGN | 0.02 | 0.01 | blup | 51 | 0.01 | 3.4e-02 | -4.64 | -5.5 | 4.2e-08 | 0.06 | 0.01 | 0.80 | FALSE |
18 | The Cancer Genome Atlas | Lung Adenocarcinoma | OGN | 0.07 | 0.12 | blup | 52 | 0.14 | 1.2e-15 | -4.94 | -5.4 | 7.2e-08 | 0.05 | 0.03 | 0.97 | FALSE |
19 | The Cancer Genome Atlas | Lung Adenocarcinoma | PHF2 | 0.07 | 0.03 | blup | 104 | 0.05 | 1.9e-06 | -4.31 | -5.2 | 1.7e-07 | -0.05 | 0.83 | 0.00 | FALSE |
20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CENPP | 0.06 | 0.04 | blup | 160 | 0.05 | 5.6e-06 | 5.09 | -6.0 | 2.2e-09 | 0.02 | 0.11 | 0.86 | FALSE |
21 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | OGN | 0.02 | 0.02 | blup | 52 | 0.02 | 2.8e-03 | 4.40 | -5.3 | 1.0e-07 | 0.09 | 0.03 | 0.90 | FALSE |
22 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CENPP | 0.10 | 0.01 | blup | 161 | 0.04 | 6.3e-04 | 0.31 | -5.4 | 7.0e-08 | -0.01 | 0.10 | 0.66 | FALSE |
23 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | OGN | 0.05 | 0.02 | blup | 52 | 0.03 | 2.4e-02 | 4.40 | -5.3 | 1.3e-07 | 0.09 | 0.03 | 0.55 | FALSE |
24 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PHF2 | 0.05 | 0.03 | blup | 103 | 0.04 | 3.5e-03 | 6.26 | -7.1 | 1.3e-12 | -0.56 | 0.06 | 0.35 | TRUE |
25 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CENPP | 0.14 | 0.03 | blup | 160 | 0.04 | 6.7e-04 | 5.09 | -5.1 | 2.9e-07 | -0.03 | 0.16 | 0.64 | FALSE |
26 | The Cancer Genome Atlas | Thyroid Carcinoma | IPPK | 0.03 | 0.04 | blup | 50 | 0.04 | 6.7e-05 | 5.18 | -5.7 | 9.3e-09 | 0.07 | 0.02 | 0.98 | FALSE |
27 | The Cancer Genome Atlas | Thyroid Carcinoma | NOL8 | 0.02 | 0.01 | blup | 38 | 0.02 | 7.3e-03 | -4.63 | 5.2 | 1.8e-07 | -0.09 | 0.02 | 0.71 | FALSE |