[Hub]/) : Traits : Impedance of leg (right) :

chr9:94,394,640-97,136,378

Best TWAS P=1.33e-12 · Best GWAS P=3.25e-14 conditioned to 3.48e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex OGN 0.04 0.04 lasso 4 0.04 2.3e-05 -4.61 -5.3 1.4e-07 -0.01 0.11 0.87 FALSE
2 GTEx Brain Caudate basal ganglia PHF2 0.42 0.00 enet 33 0.04 2.4e-02 -0.16 -5.6 2.6e-08 -0.25 0.10 0.06 TRUE
3 GTEx Brain Cerebellum BICD2 0.23 0.06 enet 21 0.17 8.5e-06 5.53 5.5 3.6e-08 0.09 0.08 0.24 FALSE
4 GTEx Cells Transformed fibroblasts OGN 0.03 0.03 lasso 2 0.01 3.2e-02 -5.53 -5.5 3.2e-08 0.05 0.09 0.86 FALSE
5 GTEx Esophagus Muscularis BICD2 0.09 0.02 enet 26 0.07 5.0e-05 4.09 5.5 3.1e-08 0.11 0.09 0.59 TRUE
6 GTEx Heart Left Ventricle ECM2 0.07 0.05 lasso 3 0.02 3.1e-02 5.49 5.8 7.7e-09 -0.01 0.08 0.71 FALSE
7 GTEx Liver ECM2 0.16 0.18 enet 8 0.18 7.4e-06 -5.64 5.5 3.5e-08 -0.07 0.07 0.92 FALSE
8 GTEx Nerve Tibial OGN 0.08 0.14 lasso 9 0.12 6.3e-09 -5.13 -5.4 7.0e-08 0.09 0.12 0.88 FALSE
9 GTEx Pituitary IPPK 0.16 0.07 lasso 4 0.07 8.5e-03 -5.11 -6.1 1.3e-09 0.10 0.08 0.64 TRUE
10 GTEx Skin Sun Exposed Lower leg CENPP 0.20 0.06 lasso 9 0.14 2.9e-11 5.09 -5.5 4.0e-08 -0.02 0.39 0.61 FALSE
11 GTEx Small Intestine Terminal Ileum CENPP 0.29 0.11 enet 11 0.10 2.9e-03 -5.14 -6.0 2.4e-09 0.02 0.10 0.68 FALSE
12 NTR Blood IPPK 0.02 0.01 bslmm 416 0.01 9.9e-06 -5.53 -5.2 1.7e-07 0.07 0.07 0.93 FALSE
13 The Cancer Genome Atlas Bladder Urothelial Carcinoma CENPP 0.08 0.00 lasso 6 0.00 1.3e-01 -3.64 -5.2 2.2e-07 -0.04 0.04 0.33 FALSE
14 The Cancer Genome Atlas Breast Invasive Carcinoma CENPP 0.07 0.03 lasso 5 0.06 2.1e-11 5.09 -6.4 1.8e-10 0.02 0.06 0.94 TRUE
15 The Cancer Genome Atlas Colon Adenocarcinoma CENPP 0.21 0.04 enet 16 0.10 1.9e-06 5.09 -6.1 8.1e-10 0.11 0.07 0.78 FALSE
16 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CENPP 0.06 0.02 blup 160 0.04 6.3e-05 5.09 -6.4 1.8e-10 0.03 0.07 0.87 FALSE
17 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma OGN 0.02 0.01 blup 51 0.01 3.4e-02 -4.64 -5.5 4.2e-08 0.06 0.01 0.80 FALSE
18 The Cancer Genome Atlas Lung Adenocarcinoma OGN 0.07 0.12 blup 52 0.14 1.2e-15 -4.94 -5.4 7.2e-08 0.05 0.03 0.97 FALSE
19 The Cancer Genome Atlas Lung Adenocarcinoma PHF2 0.07 0.03 blup 104 0.05 1.9e-06 -4.31 -5.2 1.7e-07 -0.05 0.83 0.00 FALSE
20 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CENPP 0.06 0.04 blup 160 0.05 5.6e-06 5.09 -6.0 2.2e-09 0.02 0.11 0.86 FALSE
21 The Cancer Genome Atlas Lung Squamous Cell Carcinoma OGN 0.02 0.02 blup 52 0.02 2.8e-03 4.40 -5.3 1.0e-07 0.09 0.03 0.90 FALSE
22 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma CENPP 0.10 0.01 blup 161 0.04 6.3e-04 0.31 -5.4 7.0e-08 -0.01 0.10 0.66 FALSE
23 The Cancer Genome Atlas Pancreatic Adenocarcinoma OGN 0.05 0.02 blup 52 0.03 2.4e-02 4.40 -5.3 1.3e-07 0.09 0.03 0.55 FALSE
24 The Cancer Genome Atlas Soft Tissue Sarcoma PHF2 0.05 0.03 blup 103 0.04 3.5e-03 6.26 -7.1 1.3e-12 -0.56 0.06 0.35 TRUE
25 The Cancer Genome Atlas Stomach Adenocarcinoma CENPP 0.14 0.03 blup 160 0.04 6.7e-04 5.09 -5.1 2.9e-07 -0.03 0.16 0.64 FALSE
26 The Cancer Genome Atlas Thyroid Carcinoma IPPK 0.03 0.04 blup 50 0.04 6.7e-05 5.18 -5.7 9.3e-09 0.07 0.02 0.98 FALSE
27 The Cancer Genome Atlas Thyroid Carcinoma NOL8 0.02 0.01 blup 38 0.02 7.3e-03 -4.63 5.2 1.8e-07 -0.09 0.02 0.71 FALSE