Best TWAS P=9.91e-12 · Best GWAS P=1.69e-08 conditioned to 2.81e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | DCAF4 | 0.20 | 0.05 | lasso | 7 | 0.18 | 1.1e-14 | -4.4 | -5.2 | 1.7e-07 | -0.04 | 0.07 | 0.93 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | DCAF4 | 0.23 | 0.07 | enet | 30 | 0.13 | 4.3e-07 | -4.3 | -5.6 | 2.0e-08 | -0.01 | 0.07 | 0.91 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | DCAF4 | 0.24 | 0.10 | lasso | 6 | 0.18 | 1.2e-09 | -4.4 | -5.9 | 4.3e-09 | 0.01 | 0.17 | 0.81 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | DCAF4 | 0.16 | 0.07 | lasso | 4 | 0.03 | 4.4e-02 | 4.7 | -5.3 | 1.3e-07 | 0.02 | 0.08 | 0.31 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | DPF3 | 0.39 | 0.40 | lasso | 4 | 0.39 | 9.6e-31 | -5.0 | -5.1 | 2.6e-07 | 0.06 | 0.10 | 0.89 | FALSE |
| 6 | GTEx | Colon Sigmoid | DCAF4 | 0.30 | 0.10 | lasso | 9 | 0.11 | 1.3e-04 | -5.3 | -5.6 | 2.0e-08 | -0.01 | 0.03 | 0.80 | FALSE |
| 7 | GTEx | Colon Transverse | DCAF4 | 0.26 | 0.27 | lasso | 10 | 0.27 | 2.7e-13 | -4.4 | -5.2 | 2.0e-07 | 0.00 | 0.27 | 0.72 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | DCAF4 | 0.18 | 0.01 | enet | 10 | 0.06 | 3.0e-03 | -5.3 | -6.4 | 1.3e-10 | -0.04 | 0.04 | 0.71 | FALSE |
| 9 | GTEx | Esophagus Mucosa | DCAF4 | 0.30 | 0.19 | enet | 35 | 0.23 | 1.3e-15 | -5.3 | -5.7 | 1.3e-08 | -0.06 | 0.02 | 0.98 | FALSE |
| 10 | GTEx | Esophagus Mucosa | ZFYVE1 | 0.10 | 0.00 | lasso | 7 | 0.00 | 2.0e-01 | -5.3 | -6.5 | 9.7e-11 | 0.02 | 0.10 | 0.67 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | PAPLN | 0.30 | 0.11 | lasso | 5 | 0.17 | 5.2e-14 | -4.9 | 5.6 | 2.2e-08 | -0.02 | 0.11 | 0.88 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | RP4-647C14.3 | 0.25 | 0.11 | lasso | 6 | 0.13 | 7.3e-11 | -4.9 | 5.6 | 1.9e-08 | -0.02 | 0.11 | 0.88 | FALSE |
| 13 | GTEx | Spleen | DCAF4 | 0.47 | 0.12 | enet | 10 | 0.19 | 1.5e-05 | -4.4 | -6.3 | 3.9e-10 | 0.02 | 0.11 | 0.84 | FALSE |
| 14 | GTEx | Testis | AREL1 | 0.20 | 0.14 | enet | 34 | 0.13 | 2.1e-06 | 3.6 | 5.1 | 3.1e-07 | -0.04 | 0.89 | 0.06 | TRUE |
| 15 | NTR | Blood | DCAF4 | 0.04 | 0.03 | lasso | 6 | 0.03 | 6.5e-09 | -5.3 | -5.6 | 2.1e-08 | 0.00 | 0.02 | 0.98 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DCAF4 | 0.04 | 0.02 | blup | 83 | 0.03 | 1.2e-04 | -4.6 | -6.1 | 8.3e-10 | -0.01 | 0.03 | 0.93 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FAM161B | 0.03 | 0.03 | enet | 5 | 0.03 | 4.9e-04 | -4.8 | -5.4 | 7.8e-08 | 0.10 | 0.01 | 0.88 | FALSE |
| 18 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FAM161B | 0.03 | 0.01 | blup | 57 | 0.02 | 9.5e-04 | 3.8 | -5.4 | 5.2e-08 | 0.09 | 0.02 | 0.58 | TRUE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | DPF3 | 0.10 | 0.02 | blup | 210 | 0.07 | 1.9e-07 | 4.8 | 6.8 | 9.9e-12 | -0.04 | 0.19 | 0.79 | TRUE |