Hub : Genes

PAPLN

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.0940 0.0510 9.1e-03 0.049 NA -0.001 NA 0.014 3.1e-04 NA 4.2e-01 NA 3.7e-02
2 GTEx Skin Not Sun Exposed Suprapubic 0.1300 0.0590 6.6e-03 0.161 NA 0.080 NA 0.154 3.6e-09 NA 3.7e-05 NA 8.5e-09
3 GTEx Skin Sun Exposed Lower leg 0.2990 0.0610 4.4e-08 0.112 NA 0.167 NA 0.170 1.7e-09 NA 8.8e-14 NA 5.2e-14
4 GTEx Thyroid 0.1110 0.0350 3.5e-05 0.018 NA 0.031 NA 0.032 1.4e-02 NA 2.0e-03 NA 1.5e-03
5 METSIM Adipose 0.0364 0.0186 1.3e-02 0.031 0.007 0.006 0.013 0.020 1.7e-05 2.9e-02 3.1e-02 3.4e-03 4.8e-04
6 YFS Blood 0.0376 0.0106 8.6e-09 0.027 0.034 0.029 0.035 0.029 3.0e-09 2.4e-11 5.2e-10 1.1e-11 7.3e-10
7 TCGA Breast Invasive Carcinoma 0.0521 0.0214 7.8e-05 0.019 0.027 0.019 NA 0.022 7.6e-05 2.9e-06 8.1e-05 NA 1.8e-05
8 TCGA Kidney Renal Clear Cell Carcinoma 0.0832 0.0329 1.4e-03 0.001 0.025 0.023 NA -0.002 2.4e-01 6.9e-04 1.1e-03 NA 8.5e-01
9 TCGA Lung Adenocarcinoma 0.0259 0.0137 6.6e-03 0.026 0.018 0.016 NA 0.017 4.8e-04 3.1e-03 4.6e-03 NA 4.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.7 1.1 4.8 1.2 1.2 0.5 -0.2 0.1 -0.9 -0.8 -2.2 -0.5
Bipolar Disorder or Schizophrenia 1.0 2.5 8.9 -0.5 0.0 0.7 -1.6 -0.4 -1.0 -0.9 -2.8 -3.0
Depressed Affect (Nagel 2018) 0.7 1.4 6.4 1.1 0.7 -0.4 0.9 -0.4 1.0 2.5 -1.3 -0.7
Depression (Nagel 2018) 1.3 2.0 6.7 1.8 1.7 1.3 -0.8 -0.9 1.3 2.6 -0.1 -0.6
Intelligence (Savage-Jansen 2018) 0.9 2.7 6.5 2.5 2.4 1.9 -1.6 0.7 -1.3 -0.3 -1.3 -1.3
Neuroticism (Nagel 2018) 0.6 1.5 5.6 1.6 1.1 -0.1 0.5 -0.3 1.1 2.4 -1.1 -1.1
Schizophrenia (2018) 1.3 2.6 11.3 -1.7 -1.0 0.5 -1.9 -0.6 -0.6 -0.6 -1.9 -3.4
Schizophrenia vs Biploar Disorder 0.9 1.2 5.3 -2.3 -1.9 -1.0 0.6 -0.6 0.4 0.3 0.4 0.1
Worry (Nagel 2018) 0.5 1.1 3.3 1.5 1.1 -0.2 0.0 -0.4 1.6 1.8 -0.3 -0.6
Alzheimer’s Disease (in mother) 1.6 1.8 4.4 1.7 0.6 -1.2 2.1 -0.1 -1.5 -0.3 1.4 1.8
Alzheimer’s Disease (in father) 0.6 0.6 1.6 -0.6 -0.9 -0.5 -0.1 0.3 -0.7 -1.2 1.3 0.6
Alzheimer’s Disease (including proxy) 1.1 1.6 4.0 0.5 -0.5 -1.6 1.9 0.3 -2.0 -1.6 0.7 0.9
Crohns Disease (2017) 0.2 0.4 1.3 -0.3 -0.5 -0.2 -0.9 -0.2 0.7 -0.5 0.1 -1.2
Irritable Bowel Disease (IBD) 0.6 1.4 3.6 0.8 0.8 1.1 -1.8 -0.6 1.9 1.3 0.0 -1.0
Ulcerative Colitis (UC) 0.7 1.3 3.2 1.0 1.2 1.1 -1.3 -0.4 1.8 1.7 -0.4 -0.1
Major Depression (MDD) 1.0 1.2 3.2 1.3 0.8 0.6 0.3 1.0 -1.5 -0.7 -1.3 -1.8
Reaction Time 0.9 1.8 4.9 2.0 2.2 2.0 -1.1 1.2 0.4 0.1 -0.4 0.1
Verbal and Numeric Reasoning (VNR) 1.3 3.2 7.4 2.5 2.7 2.5 -1.6 0.3 -2.0 -0.2 -0.7 -1.3
Breast Cancer 0.2 0.5 1.7 0.7 0.5 -0.3 0.7 -0.0 0.4 1.3 0.2 1.0
Ovarian Cancer 0.3 0.4 2.2 0.3 0.1 0.2 0.3 0.3 -1.1 -1.5 0.2 0.0
Prostate Cancer 1.8 2.5 7.7 1.5 1.3 0.6 0.8 -0.9 0.5 2.0 2.8 2.2
Age at First Birth 0.9 1.3 3.8 0.9 0.9 0.9 -0.9 -2.0 0.5 1.9 0.3 -0.5
Bipolar Disorder (2011) 1.5 1.5 4.7 -1.0 -0.6 0.1 -1.4 -1.4 -0.5 -0.7 -2.2 -1.6
Body Mass Index (BMI) (2010) 0.8 1.1 2.5 -1.2 -1.4 -1.6 1.6 -0.7 -0.1 -0.2 -0.0 0.8
Coronary Artery Disease (CAD) 0.8 0.9 3.4 -1.2 -1.1 -0.8 -0.6 0.8 0.1 -1.8 -0.4 0.5
Crohns Disease (2012) 0.3 0.5 1.2 0.5 -0.4 -1.1 0.6 -0.2 1.1 0.0 0.9 0.7
Mean Putamen Volume 1.0 1.1 3.4 -1.6 -1.6 -0.9 -0.2 -1.8 -0.2 0.3 -0.3 0.4
Fasting Glucose 0.4 0.5 1.6 -1.3 -0.8 0.3 -1.0 0.2 -0.4 -0.6 -0.7 -0.1
HbA1C 1.9 2.1 8.9 0.4 0.2 -0.5 0.3 0.9 3.0 1.8 1.2 1.9
HDL Cholesterol 0.3 0.5 1.0 0.9 1.0 0.9 -0.2 -0.1 -0.3 -0.9 -0.7 0.2
LDL Cholesterol 0.9 1.4 4.4 0.3 0.6 0.9 -1.2 1.0 -0.8 -1.4 -1.4 -2.1
Lupus 0.1 0.2 0.5 -0.6 -0.7 -0.4 0.3 -0.5 -0.4 -0.4 0.5 -0.4
Neuroticism (2016) 0.8 1.2 4.5 -0.2 -1.0 -2.1 1.9 -0.6 0.7 0.8 -0.1 0.5
Primary Biliary Cirrhosis 1.0 1.4 3.0 -1.6 -1.7 -1.6 0.5 0.5 1.7 0.1 0.9 0.5
Rheumatoid Arthritis 0.4 0.6 2.6 0.9 0.7 0.3 0.4 -0.0 -1.6 -0.5 0.3 -0.8
Schizophrenia (2014) 1.3 2.9 8.2 -1.6 -0.8 1.2 -2.3 -1.4 -0.5 -0.9 -2.2 -2.9
Triglycerides 0.4 0.6 1.5 -1.2 -1.1 -0.9 0.4 -0.5 0.2 0.5 0.8 0.8
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.6 0.5 0.7 1.1 -1.2 -0.1 1.6 0.8 1.0 0.6
Ulcerative Colitis 1.0 1.5 4.5 1.0 1.5 1.4 -1.4 -0.1 2.1 1.0 -0.3 0.8
Blood Eosinophil Count 0.9 6.8 18.6 0.3 -0.9 -2.6 4.3 -3.5 -4.2 0.7 0.5 2.2
Blood Platelet Count 0.4 4.7 14.7 -2.3 -1.4 0.7 -2.9 -0.9 3.8 1.9 -1.7 -1.9
Blood Red Count 1.7 16.2 33.1 -3.8 -4.5 -5.5 4.7 -2.5 3.8 1.4 2.0 5.8
Blood White Count 0.5 3.8 6.4 -2.3 -2.3 -2.0 2.0 1.6 -2.5 -2.2 -0.6 1.1
Heel T-Score 0.2 1.3 6.4 -0.4 -0.2 0.4 0.0 -1.9 -2.5 -0.6 -0.3 0.9
BMI 1.5 8.9 20.8 -3.2 -3.9 -4.6 3.5 -0.5 0.7 -1.4 -0.9 4.3
Height 0.3 6.3 22.4 4.7 3.8 1.7 1.6 -0.2 -2.1 2.6 -1.4 1.3
Waist Hip Ratio (WHR) 0.2 0.8 1.9 -1.1 -0.7 0.5 -0.9 -1.0 -0.8 -0.2 0.5 -1.4
Systolic Blood Pressure 0.8 3.9 12.1 -3.5 -2.7 -1.1 -0.8 0.9 2.6 -1.9 -1.0 1.4
Smoking Status 0.5 1.3 4.0 -0.7 -1.1 -1.2 1.3 2.0 -0.8 -0.9 1.1 -0.1
Allergy or Eczema 0.6 1.5 10.1 0.2 0.4 1.1 -1.2 -0.0 0.3 -0.5 -3.2 -0.7
Cardiovascular Disease 0.2 0.8 2.8 -0.7 -0.6 -0.4 -0.0 1.7 0.5 -1.4 -0.7 0.9
Hypothyroidism (self reported) 0.5 1.2 5.3 -0.7 -0.8 -0.7 0.2 -2.3 -1.5 0.1 -1.1 -0.5
Respiratory disease 0.6 1.2 3.6 -0.5 -0.7 -1.2 1.9 -1.1 -0.6 -0.8 -1.7 0.6
Type 2 Diabetes (T2D) (2018) 1.0 1.8 6.1 -0.6 -0.8 -1.2 1.6 -0.5 -2.5 -1.8 -0.7 1.1
Lung FEV1/FVC ratio 0.7 3.5 11.5 -0.7 0.0 1.4 -3.4 -1.5 2.1 0.9 -1.6 -2.7
Lung FVC 0.8 3.9 7.9 -1.8 -2.2 -2.5 2.5 0.3 -1.5 -1.7 1.1 2.8
Neuroticism 0.6 1.5 3.7 1.3 0.5 -1.4 1.9 -1.0 1.0 1.9 -0.7 0.4
Chronotype (morning person) 1.4 3.3 10.0 3.2 2.7 1.2 0.2 -1.8 0.7 2.6 -0.0 0.9
Hair Pigment 0.1 1.6 6.2 1.5 1.3 0.6 -0.3 0.2 2.5 1.4 0.6 1.2
Tanning 0.1 0.7 1.6 1.2 1.1 0.8 -0.3 -0.5 -0.3 1.1 -0.1 -1.0
Hand grip strength (left) 1.5 4.1 10.5 2.6 1.9 0.1 1.4 0.0 3.0 3.2 0.6 2.1
Number of treatments/medications taken 0.9 1.7 5.6 0.1 0.4 0.8 -0.3 2.1 -1.8 -2.4 -0.8 0.5
Average weekly spirits intake 0.9 1.1 4.0 -0.3 -0.6 -0.5 1.0 2.0 0.6 -1.5 -0.8 1.2
Sensitivity / hurt feelings 0.6 1.0 2.9 -0.2 -0.0 0.1 -0.8 -1.4 1.1 1.1 -0.9 -1.7
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.4 -0.1 0.0 0.1 -0.2 -0.6 -0.1 0.3 0.2 -0.3
Hearing difficulty/problems: Yes 3.0 4.6 9.3 3.0 3.0 2.1 -1.3 3.0 2.4 1.4 0.6 -0.1
Relative age of first facial hair 2.4 4.9 12.9 1.5 2.2 2.8 -3.6 0.4 2.1 2.4 -0.1 -2.5
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.5 -0.3 0.4 1.2 -1.2 0.1 -0.1 -0.3 0.1 -1.2
Ever used hormone-replacement therapy (HRT) 0.8 1.0 4.0 0.2 0.8 1.8 -2.0 0.1 -0.0 -1.1 -0.3 -0.4
Ever had hysterectomy (womb removed) 1.7 1.9 5.7 -1.1 -1.3 -1.3 1.5 1.2 -0.4 -0.5 2.4 1.7
Systolic blood pressure, automated reading 1.1 3.1 7.1 -2.4 -2.2 -1.5 0.9 1.0 2.1 -1.1 0.6 2.7
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 4.8 -0.6 -0.9 -1.8 2.2 -0.1 -1.3 -1.1 -0.3 1.8
Angina 0.4 0.6 1.6 -0.9 -0.6 0.2 -1.3 0.7 1.2 0.4 -0.2 -0.2
Medication for hormone replacement therapy 0.8 0.9 3.0 0.3 0.8 1.6 -1.7 0.5 0.5 -0.7 -1.0 0.7
Vitamin and mineral supplements 0.2 0.3 0.8 -0.5 -0.5 -0.3 0.2 0.1 0.7 -0.4 0.9 0.9
Supplements: Zinc 0.8 0.9 2.4 0.6 0.1 -0.9 0.6 0.8 1.5 1.6 0.8 0.7
Medication: Co-codamol 0.8 0.9 3.3 -0.2 -0.3 -0.8 0.9 0.7 -0.1 -0.6 1.5 1.8
Medication: Metformin 0.6 0.9 2.1 0.3 0.3 0.3 1.0 0.4 -1.3 -0.8 -1.5 1.4
Diabetes (father) 0.7 0.8 3.4 -1.2 -1.0 -0.5 -0.2 -1.8 -0.9 -0.7 -0.4 0.1
Diabetes (mother) 0.6 0.8 2.7 -0.4 -0.2 0.2 -0.6 0.8 0.2 -1.6 -1.0 -1.4
Severe depression (siblings) 1.1 1.2 2.9 0.5 0.9 1.2 -1.6 0.8 -0.6 -1.7 -1.2 -0.9
Pack years adult smoking proportion 1.3 2.0 6.5 1.1 0.6 -0.3 1.3 1.8 1.1 0.8 2.6 1.7
Impedance of leg (right) 2.1 10.0 31.3 2.9 4.1 5.6 -4.7 1.2 -0.0 -0.2 -1.0 -3.2
Leg fat-free mass (left) 0.8 4.5 13.0 -0.9 -1.8 -3.4 3.6 -0.4 -0.2 0.0 -0.4 3.3
Trunk fat percentage 0.2 1.0 2.9 -0.6 -0.4 -0.5 0.4 0.5 -0.9 -1.6 -1.3 1.7
Hand grip strength (right) 2.0 5.5 17.1 2.3 1.9 0.3 0.6 -1.0 4.1 4.1 0.1 2.3
Townsend deprivation index at recruitment 6.5 9.1 20.3 -3.2 -3.5 -3.5 2.9 0.8 -4.1 -4.5 -0.3 0.9
Current tobacco smoking 0.8 1.3 4.1 -0.4 -0.3 0.1 0.6 0.9 -2.0 -1.6 1.8 0.1
Average weekly fortified wine intake 2.5 2.9 6.2 2.0 2.5 2.5 -1.6 1.1 0.2 0.7 -1.9 -1.5
Maternal smoking around birth 1.4 2.0 7.1 1.7 1.4 0.7 -0.0 2.7 0.7 -0.7 1.8 1.2
Fed-up feelings 0.8 1.4 4.4 -0.7 -1.1 -1.8 2.1 0.1 0.7 0.9 -0.1 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.7 0.6 0.8 0.8 -0.6 -0.7 0.2 0.6 -0.7 -0.1
Relative age voice broke 2.6 4.0 12.2 1.1 1.8 2.8 -3.5 0.6 1.6 1.4 0.1 -2.6
Taking other prescription medications 1.9 2.9 8.0 0.6 0.4 -0.4 1.3 2.6 -2.7 -2.8 -0.2 1.2
Age when periods started (menarche) 1.2 3.0 4.7 2.1 2.2 2.2 -1.8 -0.3 0.6 1.6 1.8 -1.9
Bilateral oophorectomy (both ovaries removed) 1.4 1.7 3.9 -1.7 -1.6 -1.4 0.8 1.1 -0.9 -2.0 -0.3 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 4.8 -0.3 -0.5 0.0 -0.5 -1.4 -0.5 0.3 2.2 0.4
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.3 -1.1 -0.6 -0.1 0.2 0.3 -0.8 -1.0 -1.5 -0.2
Qualifications: CSEs or equivalent 0.9 1.2 2.2 -1.5 -1.5 -0.7 -0.2 1.4 1.3 -0.6 -1.4 -0.3
Serious illness, injury or assault to yourself 0.7 0.9 3.5 -0.3 0.2 1.1 -0.8 -1.1 -1.9 0.4 0.0 -1.0
High blood pressure 0.5 1.4 4.4 -2.1 -1.9 -1.2 0.4 -0.1 -0.1 -1.0 -0.5 1.4
Hayfever, allergic rhinitis or eczema 0.6 1.2 8.4 0.4 0.6 0.9 -0.8 -0.2 -0.1 -0.1 -2.9 -0.5
Multivitamins +/- minerals 0.6 0.8 2.3 0.6 0.7 0.6 -0.3 1.5 -1.0 -0.7 -1.1 -0.8
Stomach or abdominal pain in last month 0.5 0.7 2.8 -0.7 -0.8 -0.9 0.0 -0.1 -0.7 -1.7 -0.8 0.2
Supplements: Glucosamine 0.6 0.8 2.9 0.6 0.3 -0.3 0.9 -1.3 0.2 1.7 0.2 1.0
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 2.2 0.8 0.5 -0.2 0.4 1.1 1.1 -0.2 1.5 0.7
Medication: Atenolol 1.5 1.9 5.1 1.5 1.5 1.3 -0.9 2.2 1.6 -0.3 -0.1 1.5
Medication: Levothyroxine sodium 0.8 1.4 5.6 0.1 0.0 -0.2 0.2 -2.3 0.7 2.4 -0.6 -0.5
Sitting height 0.5 3.5 10.8 1.3 0.2 -1.2 2.3 3.3 0.1 -1.7 -1.7 2.4
Chronic bronchitis/emphysema (father) 0.9 1.1 2.4 1.0 0.2 -1.2 1.6 0.2 1.1 1.3 0.2 1.3
High blood pressure (mother) 0.5 0.7 2.4 -0.6 -0.1 0.6 -1.4 -0.8 0.1 -0.4 -1.6 -0.6
Body mass index (BMI) 1.2 5.1 11.9 -2.9 -3.2 -3.5 2.3 -0.5 0.3 -1.3 -0.5 2.9
Impedance of leg (left) 1.7 8.2 25.7 2.5 3.6 5.1 -4.4 1.0 -0.0 -0.2 -0.8 -2.8
Leg predicted mass (left) 0.8 4.4 13.0 -0.8 -1.7 -3.4 3.6 -0.3 -0.2 -0.0 -0.5 3.4
Trunk fat mass 0.4 1.7 6.1 -0.8 -0.9 -1.3 1.3 0.3 -0.8 -1.3 -1.3 2.5
Waist circumference 0.8 2.9 6.1 -2.4 -2.5 -2.5 1.4 -0.4 -0.5 -1.6 -0.9 1.6
Number of incorrect matches in round 0.9 1.5 7.5 0.9 0.1 -1.3 2.7 0.3 -1.7 0.1 -0.0 0.7
Past tobacco smoking 0.2 0.4 1.5 0.2 0.7 1.2 -1.0 -0.8 0.3 0.4 0.2 -0.3
Alcohol usually taken with meals 0.6 1.0 2.8 0.5 0.5 -0.1 0.2 -1.5 1.2 1.7 -1.3 -0.6
Nervous feelings 0.5 0.8 3.6 0.5 -0.2 -0.8 0.5 -1.0 1.3 1.9 -0.0 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.8 1.3 1.0 0.1 0.3 -0.2 1.3 1.3 -0.1 0.0
Hearing difficulty/problems with background noise 1.3 2.1 6.7 2.6 2.0 -0.0 1.0 2.5 0.4 0.2 0.6 0.9
Hair/balding pattern: Pattern 2 0.9 1.1 2.4 -1.5 -1.3 -0.7 -0.1 0.2 -1.4 -1.0 -1.0 -1.3
Had menopause 0.7 0.9 2.2 0.6 0.9 1.5 -1.1 -0.4 1.0 1.1 0.2 -1.1
Had other major operations 1.3 1.6 3.3 -1.1 -1.2 -1.4 1.4 0.2 -1.3 -1.3 1.2 1.8
Forced vital capacity (FVC) 0.4 1.6 5.2 0.4 -0.1 -0.8 2.3 0.7 -1.8 -0.7 0.1 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 6.1 -0.7 -1.3 -1.3 1.1 -0.4 -1.4 -0.5 2.5 1.1
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 1.1 -0.4 -0.1 0.0 -0.7 0.5 -0.0 -1.1 -0.2 -0.3
Qualifications: None of the above 1.2 2.6 5.1 -2.2 -2.3 -2.0 1.3 0.1 1.4 -0.3 1.0 2.0
Financial difficulties in last 2 years 2.1 2.9 9.7 -2.8 -2.3 -1.5 0.2 -3.1 -0.6 -0.4 -0.8 0.1
Mouth/teeth dental problems 1.1 1.8 6.8 -1.3 -0.9 0.4 -1.0 -1.5 -0.9 0.1 -2.6 -1.5
Heart attack 0.5 0.6 1.0 0.9 0.9 1.0 -0.8 0.9 1.0 0.3 0.2 -0.1
Allergy 0.6 1.3 5.3 0.6 0.8 1.1 -1.2 1.1 1.2 0.7 2.3 0.3
Pain all over the body in last month 0.6 0.6 1.7 -0.5 -0.0 0.6 -0.4 -1.0 1.3 0.8 -0.9 0.8
Diabetes (self-reported) 0.6 0.9 3.2 -0.5 -0.4 -0.4 1.1 -0.2 -1.8 -1.2 -0.6 1.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.1 -0.6 -1.0 -0.9 0.3 -0.3 0.4 0.9 -0.6 -0.9
Medication: Ramipril 0.7 0.9 4.6 -0.0 -0.3 -0.3 0.5 1.6 2.2 0.4 0.1 0.8
Medication: Simvastatin 0.1 0.2 0.5 0.4 0.6 0.5 0.2 0.4 -0.4 -0.0 0.3 0.7
Fluid intelligence score 1.9 3.9 11.2 3.0 3.3 2.8 -2.0 -0.3 -1.1 0.0 -1.1 -0.4
Illnesses of siblings 0.6 0.8 4.6 -0.6 -0.3 -0.0 -0.1 -0.3 -2.1 -0.8 -0.8 -0.7
Neuroticism score 0.5 1.1 3.3 0.7 0.0 -1.6 1.5 -0.7 0.9 1.8 0.0 0.4
Weight 0.8 3.9 9.6 -1.6 -2.1 -3.0 2.8 -0.3 -0.4 -0.8 -1.0 3.1
Impedance of arm (right) 2.2 10.1 22.1 2.8 3.8 4.7 -3.9 2.0 -2.1 -0.5 -1.8 -4.5
Arm fat percentage (right) 0.6 2.2 4.2 -2.1 -1.9 -1.8 1.0 0.5 -1.1 -1.8 -1.3 1.2
Trunk fat-free mass 0.6 3.7 11.0 -0.6 -1.6 -2.8 3.3 -0.7 0.4 0.9 -0.1 3.2
Hip circumference 0.4 1.8 3.7 -1.2 -1.3 -1.8 1.5 0.5 -0.2 -1.3 -1.4 1.9
Time employed in main current job 4.3 4.9 12.4 1.8 0.7 -1.2 2.4 0.5 2.7 3.5 2.2 3.0
Alcohol intake versus 10 years previously 2.0 3.0 7.7 -2.8 -2.8 -2.2 1.1 -1.9 -0.2 -0.6 0.4 1.4
Father’s age at death 2.0 2.7 5.5 2.3 2.1 1.7 -0.7 -2.3 -0.5 1.9 -0.7 -1.1
Worrier / anxious feelings 0.8 1.4 3.3 1.8 1.6 0.5 -0.5 -0.6 1.7 1.6 -0.2 0.8
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.2 5.2 -1.2 -1.5 -2.2 2.3 -0.1 -1.5 -1.7 -0.9 0.7
Falls in the last year 0.6 0.8 3.6 0.0 -0.0 -1.0 1.1 -0.7 -0.3 0.9 -0.2 1.9
Hair/balding pattern: Pattern 3 1.3 1.9 3.5 1.2 1.4 1.9 -1.5 -1.2 1.7 1.6 0.6 -0.7
Number of live births 0.4 0.5 1.2 -1.1 -1.1 -0.9 0.7 0.1 0.1 -0.4 0.2 0.9
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.0 -0.4 -0.6 -0.9 1.4 -0.1 -1.1 -0.7 -1.0 1.2
Pulse rate 0.9 1.5 5.5 -1.4 -1.2 -0.6 -0.2 0.4 0.2 -1.9 -2.3 -0.2
Happiness 1.7 2.1 7.1 2.5 2.0 0.4 0.2 2.7 0.9 -0.0 -0.3 -0.4
Noisy workplace 1.9 2.3 5.7 -1.0 -1.6 -2.1 2.4 1.9 -0.6 -1.7 -0.1 0.9
Qualifications: A levels/AS levels or equivalent 0.7 1.5 5.5 1.2 1.1 0.4 -0.7 -1.7 1.0 2.3 -0.7 -0.7
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 1.5 -0.7 -0.6 -0.7 0.2 0.7 1.2 -0.5 0.7 0.6
Mouth/teeth dental problems: Dentures 4.6 7.7 27.9 3.6 2.4 -0.2 2.4 0.5 1.6 3.2 5.3 2.1
Asthma 1.5 2.9 5.8 -1.3 -1.7 -2.3 2.4 -1.1 -2.2 -1.5 -1.5 0.0
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 3.3 -1.7 -1.6 -0.7 -0.1 0.2 -1.5 -1.8 -1.0 -0.3
Medication: Cholesterol lowering 0.8 1.3 3.6 1.4 1.2 0.6 0.3 1.9 -0.1 -0.4 0.9 1.8
Depression (self-reported) 0.8 0.9 3.2 1.8 1.5 0.5 0.2 1.1 -0.9 -0.6 0.5 -0.1
Medication: Lansoprazole 1.6 1.8 4.8 1.7 0.6 -1.2 2.1 0.7 0.3 0.8 1.1 2.2
Prospective memory result 3.2 4.0 8.0 -2.5 -2.7 -2.5 1.8 0.2 -2.8 -1.8 1.3 0.3
Lung cancer (father) 1.6 1.8 6.6 -0.4 -1.0 -2.2 2.6 0.7 -0.4 -0.3 1.0 1.5
Illnesses of mother 0.3 0.4 1.5 0.3 0.1 -0.1 0.1 -0.8 0.8 0.6 0.3 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.7 -0.2 -0.5 -0.9 1.4 0.7 -1.6 -1.3 -0.3 0.9
Pulse wave Arterial Stiffness index 0.6 0.7 1.6 -1.0 -0.9 -0.4 0.3 0.5 -1.0 -1.0 -1.3 -0.2
Impedance of arm (left) 1.7 7.9 16.2 2.8 3.6 4.0 -2.9 1.1 -2.5 -0.3 -1.7 -3.9
Arm fat mass (right) 0.8 3.4 7.0 -2.0 -2.2 -2.6 2.2 0.3 -0.8 -1.7 -1.0 2.4
Trunk predicted mass 0.7 3.8 11.6 -0.5 -1.5 -2.8 3.4 -0.7 0.4 0.8 -0.2 3.2
Standing height 0.2 2.4 8.0 2.8 2.1 0.8 1.4 0.1 -1.4 1.4 -1.0 1.2
Length of working week for main job 1.4 1.6 4.4 -1.1 -1.3 -1.2 1.2 -0.5 -2.1 -1.8 -0.3 0.9
Exposure to tobacco smoke at home 1.0 1.2 3.0 -1.7 -1.7 -1.4 0.3 0.3 0.2 -1.2 -0.2 0.9
Breastfed as a baby 1.4 1.8 4.4 0.9 1.2 2.1 -1.9 0.0 -1.0 -0.5 -0.7 -2.0
Tense / ‘highly strung’ 0.5 0.8 2.4 1.5 0.7 -0.9 1.0 0.2 1.0 0.5 0.1 1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 3.1 0.8 0.9 0.6 -0.8 1.8 -0.4 -0.8 -0.5 -1.0
Hair/balding pattern: Pattern 4 0.3 0.7 1.9 1.0 1.2 1.4 -0.9 0.0 0.4 -0.4 -0.7 0.3
Birth weight of first child 0.3 0.5 3.5 0.5 0.3 0.6 -0.2 0.2 -1.9 -0.7 -0.1 -0.3
Peak expiratory flow (PEF) 0.4 1.0 3.1 -1.1 -1.1 -1.1 1.1 -0.3 -0.1 -0.5 -0.9 1.8
Pulse wave reflection index 0.2 0.2 0.7 0.0 0.3 0.7 -0.3 -0.1 -0.8 0.3 0.2 -0.8
Ever highly irritable/argumentative for 2 days 1.0 1.1 5.2 -0.2 -1.0 -2.3 1.3 0.8 -1.0 -0.8 0.2 0.1
Loud music exposure frequency 0.8 0.9 2.2 0.3 0.3 0.0 -0.1 1.0 -1.5 -1.5 -1.0 -1.2
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 9.6 1.0 0.9 0.6 -1.1 -2.1 1.9 3.1 0.4 -0.6
Mouth/teeth dental problems: Bleeding gums 2.0 2.5 5.9 -2.3 -2.4 -2.4 0.9 0.0 0.4 -1.7 -1.4 0.3
Blood clot in the leg (DVT) 1.3 1.6 4.3 -1.6 -1.6 -1.2 0.8 -2.1 -1.6 -0.5 0.5 -0.2
Medication: Paracetamol 1.6 2.7 7.8 -2.7 -2.8 -2.1 0.2 0.4 0.3 -1.3 0.4 1.5
Headache pain in last month 1.5 2.6 9.2 -1.6 -1.6 -1.4 0.8 1.0 -1.8 -3.0 -1.7 0.3
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.4 -1.1 -1.1 -0.7 -0.3 -1.2 0.4 0.3 -0.9 -1.1
Glaucoma (self-reported) 1.3 1.5 4.4 1.1 0.6 0.1 0.6 1.2 -1.8 -2.1 -1.4 0.8
Gout (self-reported) 0.7 0.9 3.0 -0.8 -0.5 0.5 -1.5 0.5 -1.2 -1.7 0.3 -0.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 5.8 -0.2 -0.4 -0.9 0.7 -2.4 -0.7 0.8 -0.8 0.2
Medication: Amlodipine 0.9 1.3 3.6 -1.2 -1.0 -1.1 0.9 1.2 1.0 0.1 0.9 1.9
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.9 -1.2 -1.1 -0.9 0.6 -1.7 -0.6 -0.0 -0.2 -0.7
Birth weight 0.6 1.4 4.0 1.2 1.1 1.3 -0.4 -2.0 -0.3 1.8 0.5 -0.5
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.4 0.2 0.4 0.9 -0.9 0.1 1.2 0.6 0.0 -0.5
High blood pressure (siblings) 0.6 0.9 4.1 0.9 0.6 0.1 -0.1 1.1 2.0 0.4 -0.1 1.2
Forced vital capacity (FVC), Best measure 0.6 2.2 6.9 0.5 -0.1 -1.0 2.3 1.5 -2.6 -1.5 -0.1 1.5
Body fat percentage 0.3 1.2 3.2 -1.1 -0.9 -0.9 0.5 0.3 -0.4 -1.5 -1.3 1.8
Leg fat percentage (right) 0.2 0.9 3.8 -0.8 -0.6 -0.4 0.1 0.4 0.9 -1.0 -1.1 1.9
Arm fat-free mass (right) 1.0 4.9 14.0 -1.2 -2.0 -3.3 3.4 -1.3 0.1 0.2 0.0 3.7
Exposure to tobacco smoke outside home 1.1 1.5 3.4 -1.4 -1.5 -1.8 1.0 0.4 -0.9 -1.8 0.4 0.6
Comparative body size at age 10 1.3 3.5 9.9 1.1 0.3 -1.5 2.3 2.4 1.5 0.5 2.0 3.2
Number of full brothers 0.7 0.8 2.7 0.9 0.5 0.0 1.1 -0.2 -0.4 -0.1 1.6 1.6
Worry too long after embarrassment 0.4 0.7 3.2 0.8 0.8 0.4 -0.1 -1.8 0.3 1.2 -0.1 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.2 -0.7 -0.8 -1.0 0.1 -0.7 -0.2 0.0 0.1 -1.5
Wheeze or whistling in the chest in last year 0.4 0.8 3.9 0.8 0.8 0.5 -0.4 0.2 1.0 0.3 -2.0 0.2
Number of children fathered 1.8 2.0 8.1 0.9 0.8 1.1 -0.5 -0.3 2.8 1.8 0.3 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.0 1.1 1.4 1.4 -0.8 -0.3 0.6 1.2 -0.1 -0.0
Age at first live birth 0.9 1.5 4.4 0.7 1.1 1.7 -2.1 -1.2 0.0 1.1 0.1 -1.6
Pulse wave peak to peak time 0.5 0.5 1.6 1.1 0.8 0.2 -0.1 -0.4 0.6 1.0 1.2 0.1
Health satisfaction 1.1 1.4 5.9 -1.4 -1.0 -0.7 -0.6 0.6 0.2 -2.4 -1.2 -0.8
Shortness of breath walking on level ground 0.4 0.5 1.2 -0.6 -0.5 -0.7 0.2 -0.9 -1.1 -0.5 -0.9 -0.4
Qualifications: College or University degree 0.5 1.5 4.0 2.0 1.4 0.5 0.6 -0.1 -1.6 -0.0 -1.9 -1.0
Eye problems/disorders: None of the above 2.0 2.3 6.1 -2.5 -1.9 -0.2 -1.7 0.5 -0.7 -1.7 0.1 -2.2
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 0.4 0.3 0.3 0.1 0.6 0.3 -0.4 0.0 0.5
Emphysema/chronic bronchitis 1.8 2.0 4.4 -2.0 -2.1 -2.0 0.9 -1.3 0.4 -0.6 0.8 1.3
Medication for pain relief, constipation, heartburn 0.7 1.2 3.0 0.9 1.0 0.8 -0.3 -1.1 0.0 1.7 -1.1 -1.7
Neck or shoulder pain in last month 2.2 3.1 9.8 -2.9 -2.4 -1.5 -0.7 -0.6 -0.6 -3.1 -0.3 0.2
Medication: Blood pressure 0.5 0.9 2.5 0.8 0.6 0.0 1.0 -0.6 -0.1 1.0 1.5 1.6
Angina (self-reported) 0.4 0.6 2.0 -0.6 -0.3 0.3 -1.2 0.9 1.4 0.6 0.3 0.0
Migraine (self-reported) 2.3 2.9 7.5 -1.7 -1.4 -0.5 -0.9 2.6 -1.6 -2.7 -0.6 -1.6
Medication: Ibuprofen 1.0 1.1 2.3 -1.5 -1.4 -0.6 -0.2 0.0 -1.4 -1.3 -1.3 -0.5
Medication: Allopurinol 0.9 1.3 3.1 -1.8 -1.6 -0.7 -0.3 -0.4 -1.6 -1.4 0.5 0.3
Medication: Omeprazole 1.7 2.0 5.5 2.2 2.4 1.8 -0.1 -0.5 0.9 1.2 0.2 1.5
Medication: Seretide 50 evohaler 1.6 1.9 8.5 -0.3 -0.7 -1.2 1.2 2.9 -0.4 -1.7 -1.3 0.3
Mean time to correctly identify matches 1.9 3.7 10.2 2.5 2.9 3.2 -2.1 1.8 0.5 0.3 0.5 0.0
Heart disease (mother) 0.5 0.6 2.6 -0.3 0.1 0.8 -1.1 1.6 -0.0 -0.6 -0.1 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 3.0 -0.2 -0.1 -0.3 -0.2 0.3 1.7 1.2 -0.1 0.8
Whole body fat mass 0.6 2.4 7.4 -1.3 -1.5 -2.0 1.8 -0.0 -0.4 -1.3 -1.3 2.7
Leg fat mass (right) 0.5 2.0 6.6 -1.2 -1.4 -1.7 1.4 0.0 0.3 -1.1 -1.3 2.6
Arm predicted mass (right) 1.0 5.2 15.5 -1.1 -2.1 -3.4 3.6 -1.2 0.2 0.2 0.2 3.9
Pulse rate, automated reading 0.2 0.8 2.8 -0.4 -0.3 -0.5 0.1 1.2 0.6 -1.4 -1.7 -0.3
Alcohol intake frequency. 1.7 3.9 12.8 -3.3 -2.8 -1.9 0.6 -3.6 -0.1 0.1 -0.1 0.3
Comparative height size at age 10 0.3 1.5 4.0 1.2 0.9 -0.0 1.6 -1.6 -2.0 1.0 0.4 1.1
Number of full sisters 1.3 1.6 6.6 -0.2 0.3 2.1 -2.6 0.4 -0.3 -0.8 -0.7 -1.2
Suffer from ‘nerves’ 0.3 0.4 1.4 0.6 0.2 -0.6 0.1 1.2 0.6 0.7 -0.1 -0.7
Overall health rating 0.8 1.7 3.7 -1.3 -1.5 -1.5 1.3 1.0 -0.9 -1.9 -0.4 1.3
Chest pain or discomfort 0.8 1.1 3.6 1.1 1.3 0.8 -0.4 0.4 1.9 0.9 -0.6 1.3
Had major operations 0.3 0.4 1.2 0.6 0.8 1.1 -0.5 -0.6 -0.7 0.3 0.4 -0.1
Age at last live birth 0.5 0.7 1.8 -0.8 -0.6 0.3 -1.3 -1.1 0.1 0.5 -0.2 -1.3
Family relationship satisfaction 1.3 1.6 2.5 1.4 1.4 1.0 -0.8 1.6 -0.9 -1.6 -1.2 -1.2
Leg pain on walking 1.0 1.2 2.8 -1.3 -1.4 -1.1 0.3 -0.5 -1.7 -1.7 -0.1 -0.5
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.9 -1.0 -0.2 0.7 -1.2 -1.8 -0.5 0.2 -0.8 -2.0
Commuting to job workplace: Car/motor vehicle 0.3 0.3 1.4 -0.1 -0.1 -0.1 -0.3 1.2 1.1 0.6 0.1 0.3
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 3.8 1.0 0.7 -0.1 0.8 1.2 -0.3 -0.8 -0.9 1.9
Medication: Aspirin 1.0 1.3 5.6 1.4 1.2 0.3 0.1 0.4 1.0 0.2 2.4 1.3
Supplements: Vitamin C 0.5 0.6 2.4 -0.0 -0.1 -0.7 0.2 -1.5 0.7 1.2 -0.5 0.0
Knee pain experienced in last month 0.7 1.1 4.1 -0.5 -0.8 -1.4 1.4 -0.4 -0.6 -0.3 0.1 2.0
Hypertension (Self-reported) 0.3 0.7 2.2 -1.5 -1.2 -0.6 0.2 0.4 -0.0 -0.9 -0.3 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.9 1.5 1.1 0.1 0.6 -0.9 1.7 1.6 0.8 1.0
Illnesses of father: Heart disease 0.7 0.9 3.0 0.4 0.8 1.0 -1.7 0.6 0.7 -0.5 -1.2 -1.1
Illnesses of siblings: Diabetes 0.5 0.6 2.1 -0.7 -0.5 0.2 0.4 0.1 -1.3 -0.9 1.4 -0.3
Smoking status: Previous 0.2 0.2 1.0 -0.2 -0.6 -1.0 0.5 0.4 0.3 0.0 -0.4 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.0 3.6 -1.2 -1.7 -1.5 1.5 1.3 -1.9 -1.8 -0.5 0.5
Whole body fat-free mass 0.8 4.7 13.5 -0.8 -1.8 -3.3 3.7 -0.8 0.2 0.6 -0.2 3.5
Leg fat-free mass (right) 1.1 5.7 15.6 -1.2 -2.2 -3.9 4.0 -0.7 -0.3 0.1 -0.3 3.6
Arm fat percentage (left) 0.6 2.4 4.2 -2.0 -1.9 -2.0 1.3 0.1 -1.2 -1.8 -1.2 1.4
Average weekly red wine intake 0.5 0.8 1.5 0.8 0.2 -1.2 1.1 1.2 0.9 -0.6 -0.3 0.8
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.8 0.1 -0.1 0.1 0.3 1.9 -1.9 -1.4 0.4 -0.1
Mood swings 0.2 0.4 0.9 0.6 0.5 -0.4 0.7 0.6 -0.2 0.7 -0.9 -0.8
Loneliness, isolation 0.2 0.3 1.8 0.4 0.1 -0.2 0.0 0.5 -0.3 -0.2 -0.8 -1.3
Long-standing illness, disability or infirmity 0.7 1.1 3.6 -1.7 -1.3 -0.7 0.0 0.0 -0.5 -1.9 0.5 0.6
Ever had bowel cancer screening 0.1 0.1 0.2 0.1 0.1 0.1 -0.4 -0.2 -0.1 0.1 0.4 0.5
Diabetes diagnosed by doctor 0.5 0.9 2.5 -0.7 -0.7 -0.5 1.1 -0.1 -1.6 -1.0 -0.7 1.2
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 1.3 -0.3 -0.4 -0.2 -0.2 0.3 0.5 -1.1 0.2 0.6
Friendships satisfaction 3.8 4.7 12.0 3.5 3.2 2.3 -1.7 2.8 -0.0 -0.5 -0.4 -1.9
Qualifications: nursing, teaching 0.5 0.8 2.4 1.6 1.3 0.8 -0.3 0.5 -0.2 1.0 -0.5 -0.8
Commuting to job workplace: Walk 0.6 0.6 2.2 -0.5 -0.6 -1.2 0.5 -1.5 0.5 0.1 -0.2 0.9
Eye problems/disorders: Cataract 1.7 2.0 6.2 1.3 1.5 1.1 0.0 -2.3 -0.0 2.5 -1.1 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.3 2.0 8.3 -1.2 -0.6 0.7 -1.8 1.5 -1.1 -2.9 -1.0 -0.4
Medication for cholesterol 0.5 0.8 1.9 -0.1 -0.4 -0.7 0.8 -1.4 -0.8 1.0 0.6 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 6.7 0.9 0.3 -0.9 2.1 2.3 -0.7 -0.2 1.2 2.6
Back pain experienced in last month 0.6 0.9 4.2 -0.9 -0.5 0.1 -0.3 0.3 0.7 -0.1 2.0 1.4
Mineral and other dietary supplements 1.0 1.4 3.2 -1.5 -0.8 0.6 -1.8 0.2 -0.0 -1.7 -0.9 -1.5
Breast cancer (self-reported) 1.6 1.9 4.3 -0.9 -1.2 -2.0 2.1 0.4 -0.9 -1.2 1.7 1.4
Asthma (self-reported) 1.7 3.3 7.0 -1.6 -2.0 -2.6 2.4 -1.2 -2.1 -1.5 -1.5 -0.1
Osteoporosis (self-reported) 3.2 3.9 8.8 1.6 1.6 1.7 -1.9 -0.6 2.8 3.0 2.3 -1.2
Osteoarthritis (self-reported) 1.6 2.1 7.0 0.8 0.2 -1.1 2.3 0.2 -0.1 0.9 2.1 2.6
Medication: Aspirin 1.2 1.6 5.2 1.8 1.6 0.9 -0.2 0.9 0.6 -0.2 2.3 1.2
Medication: Gliclazide 1.1 1.3 2.3 1.3 1.4 0.8 0.3 1.5 -1.2 -0.7 0.9 1.5
Illnesses of father: None of the above (group 1) 0.4 0.5 1.8 0.2 0.1 -0.3 1.3 0.7 0.5 0.6 1.3 0.4
Smoking status: Current 0.8 1.2 4.2 -0.6 -0.7 -0.2 0.8 0.6 -2.0 -1.5 1.6 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 5.2 -0.2 -0.8 -1.4 1.4 0.0 0.4 0.2 1.4 2.3
Whole body water mass 0.8 4.8 13.9 -1.0 -2.0 -3.4 3.7 -0.7 0.0 0.3 -0.2 3.5
Leg predicted mass (right) 1.1 5.9 16.6 -1.2 -2.2 -4.0 4.1 -0.6 -0.2 0.1 -0.2 3.6
Arm fat mass (left) 0.7 2.9 6.4 -1.7 -2.0 -2.5 2.1 -0.2 -0.6 -1.2 -0.9 2.5
Number of self-reported non-cancer illnesses 1.1 1.9 4.8 -1.8 -1.5 -0.7 0.1 1.1 -2.1 -2.2 -0.4 0.1
Average weekly champagne plus white wine intake 2.2 3.0 5.9 2.1 1.8 0.8 0.5 -1.1 2.4 2.4 0.9 2.3
Miserableness 0.5 0.9 2.3 1.5 1.1 -0.5 1.5 -0.4 -0.4 1.4 -0.1 -0.1
Guilty feelings 0.3 0.5 1.5 0.1 -0.4 -1.2 1.0 -0.0 0.3 0.3 -1.1 -0.4
Wears glasses or contact lenses 0.2 0.3 0.6 0.4 0.6 0.5 0.2 -0.0 0.8 0.2 -0.8 0.6
Ever taken oral contraceptive pill 0.6 0.7 3.6 0.1 0.2 0.6 -0.7 -0.3 -0.6 -0.9 -1.9 -0.3
Hearing aid user 0.8 0.9 2.8 0.8 0.8 0.7 -0.2 1.7 -0.5 -0.4 0.4 -1.6
Mother’s age at death 1.5 1.9 5.6 1.5 1.7 2.4 -1.4 -0.3 0.0 1.2 -0.5 -1.5
Financial situation satisfaction 0.9 1.1 2.6 -1.6 -1.5 -1.5 0.4 0.5 0.2 -1.4 -0.2 -0.2
Tinnitus: Yes, now most or all of the time 0.5 0.5 4.1 0.3 0.2 -0.0 -0.4 2.0 0.4 -0.3 0.2 -0.3
Commuting to job workplace: Public transport 0.5 0.6 3.2 -0.4 -0.4 -0.5 0.7 -1.8 -1.2 0.1 -0.0 -0.4
Eye problems/disorders: Glaucoma 0.9 1.0 1.8 1.3 0.7 -0.3 1.2 1.0 -1.0 -1.0 -0.9 1.2
Medication: Blood pressure 0.4 0.9 3.2 -0.8 -0.6 -0.4 -0.4 1.1 1.8 -0.4 -0.6 1.2
Pain type(s) experienced in last month: Hip pain 1.7 2.2 5.1 -0.1 -0.4 -1.2 1.6 1.9 -1.1 -1.5 1.9 2.2
Supplements: Fish oil (including cod liver oil) 0.9 1.2 4.5 0.4 -0.3 -1.5 2.1 0.8 -0.9 -0.1 -0.0 1.5
High cholesterol (Self-reported) 0.2 0.4 0.8 0.6 0.8 0.8 -0.8 0.9 0.0 -0.3 0.5 0.4
Medication: Bendroflumethiazide 0.3 0.5 2.7 -0.2 -0.3 -0.7 0.7 0.4 0.5 -0.2 -0.1 1.7
Medication: Paracetamol 0.7 1.1 3.1 -1.7 -1.8 -1.4 0.1 0.4 0.4 -0.9 -0.4 0.6
Medication: Lisinopril 1.2 1.6 6.1 -0.9 -1.2 -1.3 1.3 -1.4 0.0 -0.0 0.5 2.5
Medication: Atorvastatin 0.3 0.4 1.1 -0.6 -0.9 -0.7 0.3 0.4 -0.8 -1.1 0.0 0.1
Illnesses of father: High blood pressure 1.0 1.3 3.2 -1.2 -0.5 0.6 -1.3 -1.8 -0.9 -0.8 -1.7 -0.3
Alcohol drinker status: Never 1.6 1.9 5.8 -2.2 -2.0 -1.4 -0.2 -2.4 -0.5 -0.4 -0.3 -0.6
Ever smoked 0.3 0.5 1.7 0.3 -0.2 -0.5 0.8 1.3 -0.8 -0.8 0.2 0.2
Basal metabolic rate 0.8 4.7 12.7 -1.1 -2.0 -3.3 3.5 -0.7 -0.1 0.1 -0.4 3.6
Leg fat percentage (left) 0.4 1.3 5.2 -1.2 -1.1 -1.0 0.5 0.2 1.0 -1.1 -0.9 2.3
Arm fat-free mass (left) 0.9 4.5 13.2 -1.2 -2.1 -3.2 3.2 -0.6 0.5 0.1 0.1 3.6
Number of operations (self-reported) 1.8 2.7 8.2 -1.3 -1.2 -0.8 1.4 0.8 -2.9 -2.7 1.1 1.2
Average weekly beer plus cider intake 2.1 3.0 15.9 0.2 -0.7 -1.4 1.3 4.0 0.3 -1.6 1.5 1.6
Irritability 1.3 2.2 6.0 1.3 0.4 -1.4 2.5 -1.2 -0.9 1.6 1.8 1.4
Risk taking 0.4 0.5 1.0 0.9 0.6 -0.2 0.7 -1.0 0.0 0.4 1.0 1.0
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.6 0.6 0.8 1.3 -1.0 0.6 0.0 -1.1 0.1 0.1
Fractured/broken bones in last 5 years 0.8 1.0 2.3 -1.3 -1.4 -1.4 0.1 1.0 -0.3 0.5 0.3 -1.5
Age started oral contraceptive pill 1.6 2.0 6.3 0.6 0.9 1.5 -1.8 -2.5 1.0 1.5 -0.6 -1.2
Diastolic blood pressure, automated reading 0.5 1.5 10.2 0.0 0.1 0.0 -0.5 1.2 3.2 0.4 1.2 0.8
Ever depressed for a whole week 1.4 1.7 3.9 -1.1 -0.4 0.4 -1.9 0.7 -0.7 -1.7 -1.6 -2.0
Unable to work because of sickness or disability 1.2 1.6 4.0 -0.1 -0.4 -1.3 2.0 1.3 -0.3 -0.9 1.5 1.9
Commuting to job workplace: Cycle 0.8 0.9 2.9 1.7 1.6 0.8 -0.8 -0.0 0.7 1.1 0.1 -0.1
Myopia 1.3 1.8 6.1 -0.6 0.1 1.5 -2.4 -2.5 -0.3 0.1 -0.5 -1.4
Vascular/heart problems diagnosed by doctor 0.5 1.3 4.5 2.1 1.9 1.2 -0.4 -0.1 -0.2 0.8 0.5 -1.2
Cholesterol lowering medication 0.2 0.4 1.3 -1.1 -1.0 -0.5 0.3 -0.6 -0.3 -0.3 0.4 -0.2
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 4.2 2.0 2.0 1.5 -0.3 -0.7 0.7 0.8 0.2 1.5
Pain experienced in last month 1.1 1.8 5.3 1.8 1.7 1.4 -0.3 -0.1 -0.8 1.4 -0.0 -2.3
Supplements: Calcium 1.6 1.7 4.8 1.3 1.1 0.9 -0.7 -0.8 2.2 2.1 1.1 0.4
Basal cell carcinoma (self-reported) 0.1 0.1 0.8 0.1 -0.1 -0.1 0.2 -0.4 -0.1 0.1 0.3 0.9
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.0 1.2 1.2 1.1 -0.7 1.4 1.1 0.3 0.2 0.3
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 4.3 -1.5 -1.6 -1.2 1.0 -2.1 -1.6 -0.3 0.4 -0.0
Heart disease (siblings) 0.5 0.6 2.1 -0.4 0.1 0.8 -1.5 -0.3 1.2 -0.0 -1.0 0.0
Alcohol drinker status: Previous 0.2 0.3 0.8 -0.1 0.2 0.4 0.3 0.7 -0.6 -0.9 0.0 0.7
Pack years of smoking 1.5 2.3 7.8 1.4 1.0 0.1 0.9 1.6 1.4 1.3 2.8 1.5
Impedance of whole body 1.8 9.1 24.1 2.9 3.9 4.9 -4.1 1.2 -1.3 -0.3 -1.3 -3.6
Leg fat mass (left) 0.6 2.3 7.4 -1.3 -1.5 -2.0 1.6 -0.2 0.4 -0.9 -1.1 2.7
Arm predicted mass (left) 1.0 4.9 16.8 -0.9 -1.8 -3.2 3.5 -0.5 0.8 0.3 0.2 4.1