Hub : Genes

PAPLN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0940	0.0510	9.1e-03	0.049	NA	-0.001	NA	0.014	3.1e-04	NA	4.2e-01	NA	3.7e-02
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1300	0.0590	6.6e-03	0.161	NA	0.080	NA	0.154	3.6e-09	NA	3.7e-05	NA	8.5e-09
3	GTEx	Skin Sun Exposed Lower leg	0.2990	0.0610	4.4e-08	0.112	NA	0.167	NA	0.170	1.7e-09	NA	8.8e-14	NA	5.2e-14
4	GTEx	Thyroid	0.1110	0.0350	3.5e-05	0.018	NA	0.031	NA	0.032	1.4e-02	NA	2.0e-03	NA	1.5e-03
5	METSIM	Adipose	0.0364	0.0186	1.3e-02	0.031	0.007	0.006	0.013	0.020	1.7e-05	2.9e-02	3.1e-02	3.4e-03	4.8e-04
6	YFS	Blood	0.0376	0.0106	8.6e-09	0.027	0.034	0.029	0.035	0.029	3.0e-09	2.4e-11	5.2e-10	1.1e-11	7.3e-10
7	TCGA	Breast Invasive Carcinoma	0.0521	0.0214	7.8e-05	0.019	0.027	0.019	NA	0.022	7.6e-05	2.9e-06	8.1e-05	NA	1.8e-05
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0832	0.0329	1.4e-03	0.001	0.025	0.023	NA	-0.002	2.4e-01	6.9e-04	1.1e-03	NA	8.5e-01
9	TCGA	Lung Adenocarcinoma	0.0259	0.0137	6.6e-03	0.026	0.018	0.016	NA	0.017	4.8e-04	3.1e-03	4.6e-03	NA	4.1e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.7	1.1	4.8	1.2	1.2	0.5	-0.2	0.1	-0.9	-0.8	-2.2	-0.5
Bipolar Disorder or Schizophrenia	1.0	2.5	8.9	-0.5	0.0	0.7	-1.6	-0.4	-1.0	-0.9	-2.8	-3.0
Depressed Affect (Nagel 2018)	0.7	1.4	6.4	1.1	0.7	-0.4	0.9	-0.4	1.0	2.5	-1.3	-0.7
Depression (Nagel 2018)	1.3	2.0	6.7	1.8	1.7	1.3	-0.8	-0.9	1.3	2.6	-0.1	-0.6
Intelligence (Savage-Jansen 2018)	0.9	2.7	6.5	2.5	2.4	1.9	-1.6	0.7	-1.3	-0.3	-1.3	-1.3
Neuroticism (Nagel 2018)	0.6	1.5	5.6	1.6	1.1	-0.1	0.5	-0.3	1.1	2.4	-1.1	-1.1
Schizophrenia (2018)	1.3	2.6	11.3	-1.7	-1.0	0.5	-1.9	-0.6	-0.6	-0.6	-1.9	-3.4
Schizophrenia vs Biploar Disorder	0.9	1.2	5.3	-2.3	-1.9	-1.0	0.6	-0.6	0.4	0.3	0.4	0.1
Worry (Nagel 2018)	0.5	1.1	3.3	1.5	1.1	-0.2	0.0	-0.4	1.6	1.8	-0.3	-0.6
Alzheimer’s Disease (in mother)	1.6	1.8	4.4	1.7	0.6	-1.2	2.1	-0.1	-1.5	-0.3	1.4	1.8
Alzheimer’s Disease (in father)	0.6	0.6	1.6	-0.6	-0.9	-0.5	-0.1	0.3	-0.7	-1.2	1.3	0.6
Alzheimer’s Disease (including proxy)	1.1	1.6	4.0	0.5	-0.5	-1.6	1.9	0.3	-2.0	-1.6	0.7	0.9
Crohns Disease (2017)	0.2	0.4	1.3	-0.3	-0.5	-0.2	-0.9	-0.2	0.7	-0.5	0.1	-1.2
Irritable Bowel Disease (IBD)	0.6	1.4	3.6	0.8	0.8	1.1	-1.8	-0.6	1.9	1.3	0.0	-1.0
Ulcerative Colitis (UC)	0.7	1.3	3.2	1.0	1.2	1.1	-1.3	-0.4	1.8	1.7	-0.4	-0.1
Major Depression (MDD)	1.0	1.2	3.2	1.3	0.8	0.6	0.3	1.0	-1.5	-0.7	-1.3	-1.8
Reaction Time	0.9	1.8	4.9	2.0	2.2	2.0	-1.1	1.2	0.4	0.1	-0.4	0.1
Verbal and Numeric Reasoning (VNR)	1.3	3.2	7.4	2.5	2.7	2.5	-1.6	0.3	-2.0	-0.2	-0.7	-1.3
Breast Cancer	0.2	0.5	1.7	0.7	0.5	-0.3	0.7	-0.0	0.4	1.3	0.2	1.0
Ovarian Cancer	0.3	0.4	2.2	0.3	0.1	0.2	0.3	0.3	-1.1	-1.5	0.2	0.0
Prostate Cancer	1.8	2.5	7.7	1.5	1.3	0.6	0.8	-0.9	0.5	2.0	2.8	2.2
Age at First Birth	0.9	1.3	3.8	0.9	0.9	0.9	-0.9	-2.0	0.5	1.9	0.3	-0.5
Bipolar Disorder (2011)	1.5	1.5	4.7	-1.0	-0.6	0.1	-1.4	-1.4	-0.5	-0.7	-2.2	-1.6
Body Mass Index (BMI) (2010)	0.8	1.1	2.5	-1.2	-1.4	-1.6	1.6	-0.7	-0.1	-0.2	-0.0	0.8
Coronary Artery Disease (CAD)	0.8	0.9	3.4	-1.2	-1.1	-0.8	-0.6	0.8	0.1	-1.8	-0.4	0.5
Crohns Disease (2012)	0.3	0.5	1.2	0.5	-0.4	-1.1	0.6	-0.2	1.1	0.0	0.9	0.7
Mean Putamen Volume	1.0	1.1	3.4	-1.6	-1.6	-0.9	-0.2	-1.8	-0.2	0.3	-0.3	0.4
Fasting Glucose	0.4	0.5	1.6	-1.3	-0.8	0.3	-1.0	0.2	-0.4	-0.6	-0.7	-0.1
HbA1C	1.9	2.1	8.9	0.4	0.2	-0.5	0.3	0.9	3.0	1.8	1.2	1.9
HDL Cholesterol	0.3	0.5	1.0	0.9	1.0	0.9	-0.2	-0.1	-0.3	-0.9	-0.7	0.2
LDL Cholesterol	0.9	1.4	4.4	0.3	0.6	0.9	-1.2	1.0	-0.8	-1.4	-1.4	-2.1
Lupus	0.1	0.2	0.5	-0.6	-0.7	-0.4	0.3	-0.5	-0.4	-0.4	0.5	-0.4
Neuroticism (2016)	0.8	1.2	4.5	-0.2	-1.0	-2.1	1.9	-0.6	0.7	0.8	-0.1	0.5
Primary Biliary Cirrhosis	1.0	1.4	3.0	-1.6	-1.7	-1.6	0.5	0.5	1.7	0.1	0.9	0.5
Rheumatoid Arthritis	0.4	0.6	2.6	0.9	0.7	0.3	0.4	-0.0	-1.6	-0.5	0.3	-0.8
Schizophrenia (2014)	1.3	2.9	8.2	-1.6	-0.8	1.2	-2.3	-1.4	-0.5	-0.9	-2.2	-2.9
Triglycerides	0.4	0.6	1.5	-1.2	-1.1	-0.9	0.4	-0.5	0.2	0.5	0.8	0.8
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.6	0.5	0.7	1.1	-1.2	-0.1	1.6	0.8	1.0	0.6
Ulcerative Colitis	1.0	1.5	4.5	1.0	1.5	1.4	-1.4	-0.1	2.1	1.0	-0.3	0.8
Blood Eosinophil Count	0.9	6.8	18.6	0.3	-0.9	-2.6	4.3	-3.5	-4.2	0.7	0.5	2.2
Blood Platelet Count	0.4	4.7	14.7	-2.3	-1.4	0.7	-2.9	-0.9	3.8	1.9	-1.7	-1.9
Blood Red Count	1.7	16.2	33.1	-3.8	-4.5	-5.5	4.7	-2.5	3.8	1.4	2.0	5.8
Blood White Count	0.5	3.8	6.4	-2.3	-2.3	-2.0	2.0	1.6	-2.5	-2.2	-0.6	1.1
Heel T-Score	0.2	1.3	6.4	-0.4	-0.2	0.4	0.0	-1.9	-2.5	-0.6	-0.3	0.9
BMI	1.5	8.9	20.8	-3.2	-3.9	-4.6	3.5	-0.5	0.7	-1.4	-0.9	4.3
Height	0.3	6.3	22.4	4.7	3.8	1.7	1.6	-0.2	-2.1	2.6	-1.4	1.3
Waist Hip Ratio (WHR)	0.2	0.8	1.9	-1.1	-0.7	0.5	-0.9	-1.0	-0.8	-0.2	0.5	-1.4
Systolic Blood Pressure	0.8	3.9	12.1	-3.5	-2.7	-1.1	-0.8	0.9	2.6	-1.9	-1.0	1.4
Smoking Status	0.5	1.3	4.0	-0.7	-1.1	-1.2	1.3	2.0	-0.8	-0.9	1.1	-0.1
Allergy or Eczema	0.6	1.5	10.1	0.2	0.4	1.1	-1.2	-0.0	0.3	-0.5	-3.2	-0.7
Cardiovascular Disease	0.2	0.8	2.8	-0.7	-0.6	-0.4	-0.0	1.7	0.5	-1.4	-0.7	0.9
Hypothyroidism (self reported)	0.5	1.2	5.3	-0.7	-0.8	-0.7	0.2	-2.3	-1.5	0.1	-1.1	-0.5
Respiratory disease	0.6	1.2	3.6	-0.5	-0.7	-1.2	1.9	-1.1	-0.6	-0.8	-1.7	0.6
Type 2 Diabetes (T2D) (2018)	1.0	1.8	6.1	-0.6	-0.8	-1.2	1.6	-0.5	-2.5	-1.8	-0.7	1.1
Lung FEV1/FVC ratio	0.7	3.5	11.5	-0.7	0.0	1.4	-3.4	-1.5	2.1	0.9	-1.6	-2.7
Lung FVC	0.8	3.9	7.9	-1.8	-2.2	-2.5	2.5	0.3	-1.5	-1.7	1.1	2.8
Neuroticism	0.6	1.5	3.7	1.3	0.5	-1.4	1.9	-1.0	1.0	1.9	-0.7	0.4
Chronotype (morning person)	1.4	3.3	10.0	3.2	2.7	1.2	0.2	-1.8	0.7	2.6	-0.0	0.9
Hair Pigment	0.1	1.6	6.2	1.5	1.3	0.6	-0.3	0.2	2.5	1.4	0.6	1.2
Tanning	0.1	0.7	1.6	1.2	1.1	0.8	-0.3	-0.5	-0.3	1.1	-0.1	-1.0
Hand grip strength (left)	1.5	4.1	10.5	2.6	1.9	0.1	1.4	0.0	3.0	3.2	0.6	2.1
Number of treatments/medications taken	0.9	1.7	5.6	0.1	0.4	0.8	-0.3	2.1	-1.8	-2.4	-0.8	0.5
Average weekly spirits intake	0.9	1.1	4.0	-0.3	-0.6	-0.5	1.0	2.0	0.6	-1.5	-0.8	1.2
Sensitivity / hurt feelings	0.6	1.0	2.9	-0.2	-0.0	0.1	-0.8	-1.4	1.1	1.1	-0.9	-1.7
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.4	-0.1	0.0	0.1	-0.2	-0.6	-0.1	0.3	0.2	-0.3
Hearing difficulty/problems: Yes	3.0	4.6	9.3	3.0	3.0	2.1	-1.3	3.0	2.4	1.4	0.6	-0.1
Relative age of first facial hair	2.4	4.9	12.9	1.5	2.2	2.8	-3.6	0.4	2.1	2.4	-0.1	-2.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.5	-0.3	0.4	1.2	-1.2	0.1	-0.1	-0.3	0.1	-1.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	4.0	0.2	0.8	1.8	-2.0	0.1	-0.0	-1.1	-0.3	-0.4
Ever had hysterectomy (womb removed)	1.7	1.9	5.7	-1.1	-1.3	-1.3	1.5	1.2	-0.4	-0.5	2.4	1.7
Systolic blood pressure, automated reading	1.1	3.1	7.1	-2.4	-2.2	-1.5	0.9	1.0	2.1	-1.1	0.6	2.7
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	4.8	-0.6	-0.9	-1.8	2.2	-0.1	-1.3	-1.1	-0.3	1.8
Angina	0.4	0.6	1.6	-0.9	-0.6	0.2	-1.3	0.7	1.2	0.4	-0.2	-0.2
Medication for hormone replacement therapy	0.8	0.9	3.0	0.3	0.8	1.6	-1.7	0.5	0.5	-0.7	-1.0	0.7
Vitamin and mineral supplements	0.2	0.3	0.8	-0.5	-0.5	-0.3	0.2	0.1	0.7	-0.4	0.9	0.9
Supplements: Zinc	0.8	0.9	2.4	0.6	0.1	-0.9	0.6	0.8	1.5	1.6	0.8	0.7
Medication: Co-codamol	0.8	0.9	3.3	-0.2	-0.3	-0.8	0.9	0.7	-0.1	-0.6	1.5	1.8
Medication: Metformin	0.6	0.9	2.1	0.3	0.3	0.3	1.0	0.4	-1.3	-0.8	-1.5	1.4
Diabetes (father)	0.7	0.8	3.4	-1.2	-1.0	-0.5	-0.2	-1.8	-0.9	-0.7	-0.4	0.1
Diabetes (mother)	0.6	0.8	2.7	-0.4	-0.2	0.2	-0.6	0.8	0.2	-1.6	-1.0	-1.4
Severe depression (siblings)	1.1	1.2	2.9	0.5	0.9	1.2	-1.6	0.8	-0.6	-1.7	-1.2	-0.9
Pack years adult smoking proportion	1.3	2.0	6.5	1.1	0.6	-0.3	1.3	1.8	1.1	0.8	2.6	1.7
Impedance of leg (right)	2.1	10.0	31.3	2.9	4.1	5.6	-4.7	1.2	-0.0	-0.2	-1.0	-3.2
Leg fat-free mass (left)	0.8	4.5	13.0	-0.9	-1.8	-3.4	3.6	-0.4	-0.2	0.0	-0.4	3.3
Trunk fat percentage	0.2	1.0	2.9	-0.6	-0.4	-0.5	0.4	0.5	-0.9	-1.6	-1.3	1.7
Hand grip strength (right)	2.0	5.5	17.1	2.3	1.9	0.3	0.6	-1.0	4.1	4.1	0.1	2.3
Townsend deprivation index at recruitment	6.5	9.1	20.3	-3.2	-3.5	-3.5	2.9	0.8	-4.1	-4.5	-0.3	0.9
Current tobacco smoking	0.8	1.3	4.1	-0.4	-0.3	0.1	0.6	0.9	-2.0	-1.6	1.8	0.1
Average weekly fortified wine intake	2.5	2.9	6.2	2.0	2.5	2.5	-1.6	1.1	0.2	0.7	-1.9	-1.5
Maternal smoking around birth	1.4	2.0	7.1	1.7	1.4	0.7	-0.0	2.7	0.7	-0.7	1.8	1.2
Fed-up feelings	0.8	1.4	4.4	-0.7	-1.1	-1.8	2.1	0.1	0.7	0.9	-0.1	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.7	0.6	0.8	0.8	-0.6	-0.7	0.2	0.6	-0.7	-0.1
Relative age voice broke	2.6	4.0	12.2	1.1	1.8	2.8	-3.5	0.6	1.6	1.4	0.1	-2.6
Taking other prescription medications	1.9	2.9	8.0	0.6	0.4	-0.4	1.3	2.6	-2.7	-2.8	-0.2	1.2
Age when periods started (menarche)	1.2	3.0	4.7	2.1	2.2	2.2	-1.8	-0.3	0.6	1.6	1.8	-1.9
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	3.9	-1.7	-1.6	-1.4	0.8	1.1	-0.9	-2.0	-0.3	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	4.8	-0.3	-0.5	0.0	-0.5	-1.4	-0.5	0.3	2.2	0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.3	-1.1	-0.6	-0.1	0.2	0.3	-0.8	-1.0	-1.5	-0.2
Qualifications: CSEs or equivalent	0.9	1.2	2.2	-1.5	-1.5	-0.7	-0.2	1.4	1.3	-0.6	-1.4	-0.3
Serious illness, injury or assault to yourself	0.7	0.9	3.5	-0.3	0.2	1.1	-0.8	-1.1	-1.9	0.4	0.0	-1.0
High blood pressure	0.5	1.4	4.4	-2.1	-1.9	-1.2	0.4	-0.1	-0.1	-1.0	-0.5	1.4
Hayfever, allergic rhinitis or eczema	0.6	1.2	8.4	0.4	0.6	0.9	-0.8	-0.2	-0.1	-0.1	-2.9	-0.5
Multivitamins +/- minerals	0.6	0.8	2.3	0.6	0.7	0.6	-0.3	1.5	-1.0	-0.7	-1.1	-0.8
Stomach or abdominal pain in last month	0.5	0.7	2.8	-0.7	-0.8	-0.9	0.0	-0.1	-0.7	-1.7	-0.8	0.2
Supplements: Glucosamine	0.6	0.8	2.9	0.6	0.3	-0.3	0.9	-1.3	0.2	1.7	0.2	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.2	0.8	0.5	-0.2	0.4	1.1	1.1	-0.2	1.5	0.7
Medication: Atenolol	1.5	1.9	5.1	1.5	1.5	1.3	-0.9	2.2	1.6	-0.3	-0.1	1.5
Medication: Levothyroxine sodium	0.8	1.4	5.6	0.1	0.0	-0.2	0.2	-2.3	0.7	2.4	-0.6	-0.5
Sitting height	0.5	3.5	10.8	1.3	0.2	-1.2	2.3	3.3	0.1	-1.7	-1.7	2.4
Chronic bronchitis/emphysema (father)	0.9	1.1	2.4	1.0	0.2	-1.2	1.6	0.2	1.1	1.3	0.2	1.3
High blood pressure (mother)	0.5	0.7	2.4	-0.6	-0.1	0.6	-1.4	-0.8	0.1	-0.4	-1.6	-0.6
Body mass index (BMI)	1.2	5.1	11.9	-2.9	-3.2	-3.5	2.3	-0.5	0.3	-1.3	-0.5	2.9
Impedance of leg (left)	1.7	8.2	25.7	2.5	3.6	5.1	-4.4	1.0	-0.0	-0.2	-0.8	-2.8
Leg predicted mass (left)	0.8	4.4	13.0	-0.8	-1.7	-3.4	3.6	-0.3	-0.2	-0.0	-0.5	3.4
Trunk fat mass	0.4	1.7	6.1	-0.8	-0.9	-1.3	1.3	0.3	-0.8	-1.3	-1.3	2.5
Waist circumference	0.8	2.9	6.1	-2.4	-2.5	-2.5	1.4	-0.4	-0.5	-1.6	-0.9	1.6
Number of incorrect matches in round	0.9	1.5	7.5	0.9	0.1	-1.3	2.7	0.3	-1.7	0.1	-0.0	0.7
Past tobacco smoking	0.2	0.4	1.5	0.2	0.7	1.2	-1.0	-0.8	0.3	0.4	0.2	-0.3
Alcohol usually taken with meals	0.6	1.0	2.8	0.5	0.5	-0.1	0.2	-1.5	1.2	1.7	-1.3	-0.6
Nervous feelings	0.5	0.8	3.6	0.5	-0.2	-0.8	0.5	-1.0	1.3	1.9	-0.0	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.8	1.3	1.0	0.1	0.3	-0.2	1.3	1.3	-0.1	0.0
Hearing difficulty/problems with background noise	1.3	2.1	6.7	2.6	2.0	-0.0	1.0	2.5	0.4	0.2	0.6	0.9
Hair/balding pattern: Pattern 2	0.9	1.1	2.4	-1.5	-1.3	-0.7	-0.1	0.2	-1.4	-1.0	-1.0	-1.3
Had menopause	0.7	0.9	2.2	0.6	0.9	1.5	-1.1	-0.4	1.0	1.1	0.2	-1.1
Had other major operations	1.3	1.6	3.3	-1.1	-1.2	-1.4	1.4	0.2	-1.3	-1.3	1.2	1.8
Forced vital capacity (FVC)	0.4	1.6	5.2	0.4	-0.1	-0.8	2.3	0.7	-1.8	-0.7	0.1	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	6.1	-0.7	-1.3	-1.3	1.1	-0.4	-1.4	-0.5	2.5	1.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.1	-0.4	-0.1	0.0	-0.7	0.5	-0.0	-1.1	-0.2	-0.3
Qualifications: None of the above	1.2	2.6	5.1	-2.2	-2.3	-2.0	1.3	0.1	1.4	-0.3	1.0	2.0
Financial difficulties in last 2 years	2.1	2.9	9.7	-2.8	-2.3	-1.5	0.2	-3.1	-0.6	-0.4	-0.8	0.1
Mouth/teeth dental problems	1.1	1.8	6.8	-1.3	-0.9	0.4	-1.0	-1.5	-0.9	0.1	-2.6	-1.5
Heart attack	0.5	0.6	1.0	0.9	0.9	1.0	-0.8	0.9	1.0	0.3	0.2	-0.1
Allergy	0.6	1.3	5.3	0.6	0.8	1.1	-1.2	1.1	1.2	0.7	2.3	0.3
Pain all over the body in last month	0.6	0.6	1.7	-0.5	-0.0	0.6	-0.4	-1.0	1.3	0.8	-0.9	0.8
Diabetes (self-reported)	0.6	0.9	3.2	-0.5	-0.4	-0.4	1.1	-0.2	-1.8	-1.2	-0.6	1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	-0.6	-1.0	-0.9	0.3	-0.3	0.4	0.9	-0.6	-0.9
Medication: Ramipril	0.7	0.9	4.6	-0.0	-0.3	-0.3	0.5	1.6	2.2	0.4	0.1	0.8
Medication: Simvastatin	0.1	0.2	0.5	0.4	0.6	0.5	0.2	0.4	-0.4	-0.0	0.3	0.7
Fluid intelligence score	1.9	3.9	11.2	3.0	3.3	2.8	-2.0	-0.3	-1.1	0.0	-1.1	-0.4
Illnesses of siblings	0.6	0.8	4.6	-0.6	-0.3	-0.0	-0.1	-0.3	-2.1	-0.8	-0.8	-0.7
Neuroticism score	0.5	1.1	3.3	0.7	0.0	-1.6	1.5	-0.7	0.9	1.8	0.0	0.4
Weight	0.8	3.9	9.6	-1.6	-2.1	-3.0	2.8	-0.3	-0.4	-0.8	-1.0	3.1
Impedance of arm (right)	2.2	10.1	22.1	2.8	3.8	4.7	-3.9	2.0	-2.1	-0.5	-1.8	-4.5
Arm fat percentage (right)	0.6	2.2	4.2	-2.1	-1.9	-1.8	1.0	0.5	-1.1	-1.8	-1.3	1.2
Trunk fat-free mass	0.6	3.7	11.0	-0.6	-1.6	-2.8	3.3	-0.7	0.4	0.9	-0.1	3.2
Hip circumference	0.4	1.8	3.7	-1.2	-1.3	-1.8	1.5	0.5	-0.2	-1.3	-1.4	1.9
Time employed in main current job	4.3	4.9	12.4	1.8	0.7	-1.2	2.4	0.5	2.7	3.5	2.2	3.0
Alcohol intake versus 10 years previously	2.0	3.0	7.7	-2.8	-2.8	-2.2	1.1	-1.9	-0.2	-0.6	0.4	1.4
Father’s age at death	2.0	2.7	5.5	2.3	2.1	1.7	-0.7	-2.3	-0.5	1.9	-0.7	-1.1
Worrier / anxious feelings	0.8	1.4	3.3	1.8	1.6	0.5	-0.5	-0.6	1.7	1.6	-0.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	5.2	-1.2	-1.5	-2.2	2.3	-0.1	-1.5	-1.7	-0.9	0.7
Falls in the last year	0.6	0.8	3.6	0.0	-0.0	-1.0	1.1	-0.7	-0.3	0.9	-0.2	1.9
Hair/balding pattern: Pattern 3	1.3	1.9	3.5	1.2	1.4	1.9	-1.5	-1.2	1.7	1.6	0.6	-0.7
Number of live births	0.4	0.5	1.2	-1.1	-1.1	-0.9	0.7	0.1	0.1	-0.4	0.2	0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.0	-0.4	-0.6	-0.9	1.4	-0.1	-1.1	-0.7	-1.0	1.2
Pulse rate	0.9	1.5	5.5	-1.4	-1.2	-0.6	-0.2	0.4	0.2	-1.9	-2.3	-0.2
Happiness	1.7	2.1	7.1	2.5	2.0	0.4	0.2	2.7	0.9	-0.0	-0.3	-0.4
Noisy workplace	1.9	2.3	5.7	-1.0	-1.6	-2.1	2.4	1.9	-0.6	-1.7	-0.1	0.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.5	1.2	1.1	0.4	-0.7	-1.7	1.0	2.3	-0.7	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.5	-0.7	-0.6	-0.7	0.2	0.7	1.2	-0.5	0.7	0.6
Mouth/teeth dental problems: Dentures	4.6	7.7	27.9	3.6	2.4	-0.2	2.4	0.5	1.6	3.2	5.3	2.1
Asthma	1.5	2.9	5.8	-1.3	-1.7	-2.3	2.4	-1.1	-2.2	-1.5	-1.5	0.0
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.3	-1.7	-1.6	-0.7	-0.1	0.2	-1.5	-1.8	-1.0	-0.3
Medication: Cholesterol lowering	0.8	1.3	3.6	1.4	1.2	0.6	0.3	1.9	-0.1	-0.4	0.9	1.8
Depression (self-reported)	0.8	0.9	3.2	1.8	1.5	0.5	0.2	1.1	-0.9	-0.6	0.5	-0.1
Medication: Lansoprazole	1.6	1.8	4.8	1.7	0.6	-1.2	2.1	0.7	0.3	0.8	1.1	2.2
Prospective memory result	3.2	4.0	8.0	-2.5	-2.7	-2.5	1.8	0.2	-2.8	-1.8	1.3	0.3
Lung cancer (father)	1.6	1.8	6.6	-0.4	-1.0	-2.2	2.6	0.7	-0.4	-0.3	1.0	1.5
Illnesses of mother	0.3	0.4	1.5	0.3	0.1	-0.1	0.1	-0.8	0.8	0.6	0.3	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.7	-0.2	-0.5	-0.9	1.4	0.7	-1.6	-1.3	-0.3	0.9
Pulse wave Arterial Stiffness index	0.6	0.7	1.6	-1.0	-0.9	-0.4	0.3	0.5	-1.0	-1.0	-1.3	-0.2
Impedance of arm (left)	1.7	7.9	16.2	2.8	3.6	4.0	-2.9	1.1	-2.5	-0.3	-1.7	-3.9
Arm fat mass (right)	0.8	3.4	7.0	-2.0	-2.2	-2.6	2.2	0.3	-0.8	-1.7	-1.0	2.4
Trunk predicted mass	0.7	3.8	11.6	-0.5	-1.5	-2.8	3.4	-0.7	0.4	0.8	-0.2	3.2
Standing height	0.2	2.4	8.0	2.8	2.1	0.8	1.4	0.1	-1.4	1.4	-1.0	1.2
Length of working week for main job	1.4	1.6	4.4	-1.1	-1.3	-1.2	1.2	-0.5	-2.1	-1.8	-0.3	0.9
Exposure to tobacco smoke at home	1.0	1.2	3.0	-1.7	-1.7	-1.4	0.3	0.3	0.2	-1.2	-0.2	0.9
Breastfed as a baby	1.4	1.8	4.4	0.9	1.2	2.1	-1.9	0.0	-1.0	-0.5	-0.7	-2.0
Tense / ‘highly strung’	0.5	0.8	2.4	1.5	0.7	-0.9	1.0	0.2	1.0	0.5	0.1	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	3.1	0.8	0.9	0.6	-0.8	1.8	-0.4	-0.8	-0.5	-1.0
Hair/balding pattern: Pattern 4	0.3	0.7	1.9	1.0	1.2	1.4	-0.9	0.0	0.4	-0.4	-0.7	0.3
Birth weight of first child	0.3	0.5	3.5	0.5	0.3	0.6	-0.2	0.2	-1.9	-0.7	-0.1	-0.3
Peak expiratory flow (PEF)	0.4	1.0	3.1	-1.1	-1.1	-1.1	1.1	-0.3	-0.1	-0.5	-0.9	1.8
Pulse wave reflection index	0.2	0.2	0.7	0.0	0.3	0.7	-0.3	-0.1	-0.8	0.3	0.2	-0.8
Ever highly irritable/argumentative for 2 days	1.0	1.1	5.2	-0.2	-1.0	-2.3	1.3	0.8	-1.0	-0.8	0.2	0.1
Loud music exposure frequency	0.8	0.9	2.2	0.3	0.3	0.0	-0.1	1.0	-1.5	-1.5	-1.0	-1.2
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	9.6	1.0	0.9	0.6	-1.1	-2.1	1.9	3.1	0.4	-0.6
Mouth/teeth dental problems: Bleeding gums	2.0	2.5	5.9	-2.3	-2.4	-2.4	0.9	0.0	0.4	-1.7	-1.4	0.3
Blood clot in the leg (DVT)	1.3	1.6	4.3	-1.6	-1.6	-1.2	0.8	-2.1	-1.6	-0.5	0.5	-0.2
Medication: Paracetamol	1.6	2.7	7.8	-2.7	-2.8	-2.1	0.2	0.4	0.3	-1.3	0.4	1.5
Headache pain in last month	1.5	2.6	9.2	-1.6	-1.6	-1.4	0.8	1.0	-1.8	-3.0	-1.7	0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.4	-1.1	-1.1	-0.7	-0.3	-1.2	0.4	0.3	-0.9	-1.1
Glaucoma (self-reported)	1.3	1.5	4.4	1.1	0.6	0.1	0.6	1.2	-1.8	-2.1	-1.4	0.8
Gout (self-reported)	0.7	0.9	3.0	-0.8	-0.5	0.5	-1.5	0.5	-1.2	-1.7	0.3	-0.4
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	5.8	-0.2	-0.4	-0.9	0.7	-2.4	-0.7	0.8	-0.8	0.2
Medication: Amlodipine	0.9	1.3	3.6	-1.2	-1.0	-1.1	0.9	1.2	1.0	0.1	0.9	1.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.9	-1.2	-1.1	-0.9	0.6	-1.7	-0.6	-0.0	-0.2	-0.7
Birth weight	0.6	1.4	4.0	1.2	1.1	1.3	-0.4	-2.0	-0.3	1.8	0.5	-0.5
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.4	0.2	0.4	0.9	-0.9	0.1	1.2	0.6	0.0	-0.5
High blood pressure (siblings)	0.6	0.9	4.1	0.9	0.6	0.1	-0.1	1.1	2.0	0.4	-0.1	1.2
Forced vital capacity (FVC), Best measure	0.6	2.2	6.9	0.5	-0.1	-1.0	2.3	1.5	-2.6	-1.5	-0.1	1.5
Body fat percentage	0.3	1.2	3.2	-1.1	-0.9	-0.9	0.5	0.3	-0.4	-1.5	-1.3	1.8
Leg fat percentage (right)	0.2	0.9	3.8	-0.8	-0.6	-0.4	0.1	0.4	0.9	-1.0	-1.1	1.9
Arm fat-free mass (right)	1.0	4.9	14.0	-1.2	-2.0	-3.3	3.4	-1.3	0.1	0.2	0.0	3.7
Exposure to tobacco smoke outside home	1.1	1.5	3.4	-1.4	-1.5	-1.8	1.0	0.4	-0.9	-1.8	0.4	0.6
Comparative body size at age 10	1.3	3.5	9.9	1.1	0.3	-1.5	2.3	2.4	1.5	0.5	2.0	3.2
Number of full brothers	0.7	0.8	2.7	0.9	0.5	0.0	1.1	-0.2	-0.4	-0.1	1.6	1.6
Worry too long after embarrassment	0.4	0.7	3.2	0.8	0.8	0.4	-0.1	-1.8	0.3	1.2	-0.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.2	-0.7	-0.8	-1.0	0.1	-0.7	-0.2	0.0	0.1	-1.5
Wheeze or whistling in the chest in last year	0.4	0.8	3.9	0.8	0.8	0.5	-0.4	0.2	1.0	0.3	-2.0	0.2
Number of children fathered	1.8	2.0	8.1	0.9	0.8	1.1	-0.5	-0.3	2.8	1.8	0.3	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.0	1.1	1.4	1.4	-0.8	-0.3	0.6	1.2	-0.1	-0.0
Age at first live birth	0.9	1.5	4.4	0.7	1.1	1.7	-2.1	-1.2	0.0	1.1	0.1	-1.6
Pulse wave peak to peak time	0.5	0.5	1.6	1.1	0.8	0.2	-0.1	-0.4	0.6	1.0	1.2	0.1
Health satisfaction	1.1	1.4	5.9	-1.4	-1.0	-0.7	-0.6	0.6	0.2	-2.4	-1.2	-0.8
Shortness of breath walking on level ground	0.4	0.5	1.2	-0.6	-0.5	-0.7	0.2	-0.9	-1.1	-0.5	-0.9	-0.4
Qualifications: College or University degree	0.5	1.5	4.0	2.0	1.4	0.5	0.6	-0.1	-1.6	-0.0	-1.9	-1.0
Eye problems/disorders: None of the above	2.0	2.3	6.1	-2.5	-1.9	-0.2	-1.7	0.5	-0.7	-1.7	0.1	-2.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.4	0.3	0.3	0.1	0.6	0.3	-0.4	0.0	0.5
Emphysema/chronic bronchitis	1.8	2.0	4.4	-2.0	-2.1	-2.0	0.9	-1.3	0.4	-0.6	0.8	1.3
Medication for pain relief, constipation, heartburn	0.7	1.2	3.0	0.9	1.0	0.8	-0.3	-1.1	0.0	1.7	-1.1	-1.7
Neck or shoulder pain in last month	2.2	3.1	9.8	-2.9	-2.4	-1.5	-0.7	-0.6	-0.6	-3.1	-0.3	0.2
Medication: Blood pressure	0.5	0.9	2.5	0.8	0.6	0.0	1.0	-0.6	-0.1	1.0	1.5	1.6
Angina (self-reported)	0.4	0.6	2.0	-0.6	-0.3	0.3	-1.2	0.9	1.4	0.6	0.3	0.0
Migraine (self-reported)	2.3	2.9	7.5	-1.7	-1.4	-0.5	-0.9	2.6	-1.6	-2.7	-0.6	-1.6
Medication: Ibuprofen	1.0	1.1	2.3	-1.5	-1.4	-0.6	-0.2	0.0	-1.4	-1.3	-1.3	-0.5
Medication: Allopurinol	0.9	1.3	3.1	-1.8	-1.6	-0.7	-0.3	-0.4	-1.6	-1.4	0.5	0.3
Medication: Omeprazole	1.7	2.0	5.5	2.2	2.4	1.8	-0.1	-0.5	0.9	1.2	0.2	1.5
Medication: Seretide 50 evohaler	1.6	1.9	8.5	-0.3	-0.7	-1.2	1.2	2.9	-0.4	-1.7	-1.3	0.3
Mean time to correctly identify matches	1.9	3.7	10.2	2.5	2.9	3.2	-2.1	1.8	0.5	0.3	0.5	0.0
Heart disease (mother)	0.5	0.6	2.6	-0.3	0.1	0.8	-1.1	1.6	-0.0	-0.6	-0.1	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	3.0	-0.2	-0.1	-0.3	-0.2	0.3	1.7	1.2	-0.1	0.8
Whole body fat mass	0.6	2.4	7.4	-1.3	-1.5	-2.0	1.8	-0.0	-0.4	-1.3	-1.3	2.7
Leg fat mass (right)	0.5	2.0	6.6	-1.2	-1.4	-1.7	1.4	0.0	0.3	-1.1	-1.3	2.6
Arm predicted mass (right)	1.0	5.2	15.5	-1.1	-2.1	-3.4	3.6	-1.2	0.2	0.2	0.2	3.9
Pulse rate, automated reading	0.2	0.8	2.8	-0.4	-0.3	-0.5	0.1	1.2	0.6	-1.4	-1.7	-0.3
Alcohol intake frequency.	1.7	3.9	12.8	-3.3	-2.8	-1.9	0.6	-3.6	-0.1	0.1	-0.1	0.3
Comparative height size at age 10	0.3	1.5	4.0	1.2	0.9	-0.0	1.6	-1.6	-2.0	1.0	0.4	1.1
Number of full sisters	1.3	1.6	6.6	-0.2	0.3	2.1	-2.6	0.4	-0.3	-0.8	-0.7	-1.2
Suffer from ‘nerves’	0.3	0.4	1.4	0.6	0.2	-0.6	0.1	1.2	0.6	0.7	-0.1	-0.7
Overall health rating	0.8	1.7	3.7	-1.3	-1.5	-1.5	1.3	1.0	-0.9	-1.9	-0.4	1.3
Chest pain or discomfort	0.8	1.1	3.6	1.1	1.3	0.8	-0.4	0.4	1.9	0.9	-0.6	1.3
Had major operations	0.3	0.4	1.2	0.6	0.8	1.1	-0.5	-0.6	-0.7	0.3	0.4	-0.1
Age at last live birth	0.5	0.7	1.8	-0.8	-0.6	0.3	-1.3	-1.1	0.1	0.5	-0.2	-1.3
Family relationship satisfaction	1.3	1.6	2.5	1.4	1.4	1.0	-0.8	1.6	-0.9	-1.6	-1.2	-1.2
Leg pain on walking	1.0	1.2	2.8	-1.3	-1.4	-1.1	0.3	-0.5	-1.7	-1.7	-0.1	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.9	-1.0	-0.2	0.7	-1.2	-1.8	-0.5	0.2	-0.8	-2.0
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.4	-0.1	-0.1	-0.1	-0.3	1.2	1.1	0.6	0.1	0.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.8	1.0	0.7	-0.1	0.8	1.2	-0.3	-0.8	-0.9	1.9
Medication: Aspirin	1.0	1.3	5.6	1.4	1.2	0.3	0.1	0.4	1.0	0.2	2.4	1.3
Supplements: Vitamin C	0.5	0.6	2.4	-0.0	-0.1	-0.7	0.2	-1.5	0.7	1.2	-0.5	0.0
Knee pain experienced in last month	0.7	1.1	4.1	-0.5	-0.8	-1.4	1.4	-0.4	-0.6	-0.3	0.1	2.0
Hypertension (Self-reported)	0.3	0.7	2.2	-1.5	-1.2	-0.6	0.2	0.4	-0.0	-0.9	-0.3	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.9	1.5	1.1	0.1	0.6	-0.9	1.7	1.6	0.8	1.0
Illnesses of father: Heart disease	0.7	0.9	3.0	0.4	0.8	1.0	-1.7	0.6	0.7	-0.5	-1.2	-1.1
Illnesses of siblings: Diabetes	0.5	0.6	2.1	-0.7	-0.5	0.2	0.4	0.1	-1.3	-0.9	1.4	-0.3
Smoking status: Previous	0.2	0.2	1.0	-0.2	-0.6	-1.0	0.5	0.4	0.3	0.0	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	3.6	-1.2	-1.7	-1.5	1.5	1.3	-1.9	-1.8	-0.5	0.5
Whole body fat-free mass	0.8	4.7	13.5	-0.8	-1.8	-3.3	3.7	-0.8	0.2	0.6	-0.2	3.5
Leg fat-free mass (right)	1.1	5.7	15.6	-1.2	-2.2	-3.9	4.0	-0.7	-0.3	0.1	-0.3	3.6
Arm fat percentage (left)	0.6	2.4	4.2	-2.0	-1.9	-2.0	1.3	0.1	-1.2	-1.8	-1.2	1.4
Average weekly red wine intake	0.5	0.8	1.5	0.8	0.2	-1.2	1.1	1.2	0.9	-0.6	-0.3	0.8
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.8	0.1	-0.1	0.1	0.3	1.9	-1.9	-1.4	0.4	-0.1
Mood swings	0.2	0.4	0.9	0.6	0.5	-0.4	0.7	0.6	-0.2	0.7	-0.9	-0.8
Loneliness, isolation	0.2	0.3	1.8	0.4	0.1	-0.2	0.0	0.5	-0.3	-0.2	-0.8	-1.3
Long-standing illness, disability or infirmity	0.7	1.1	3.6	-1.7	-1.3	-0.7	0.0	0.0	-0.5	-1.9	0.5	0.6
Ever had bowel cancer screening	0.1	0.1	0.2	0.1	0.1	0.1	-0.4	-0.2	-0.1	0.1	0.4	0.5
Diabetes diagnosed by doctor	0.5	0.9	2.5	-0.7	-0.7	-0.5	1.1	-0.1	-1.6	-1.0	-0.7	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	1.3	-0.3	-0.4	-0.2	-0.2	0.3	0.5	-1.1	0.2	0.6
Friendships satisfaction	3.8	4.7	12.0	3.5	3.2	2.3	-1.7	2.8	-0.0	-0.5	-0.4	-1.9
Qualifications: nursing, teaching	0.5	0.8	2.4	1.6	1.3	0.8	-0.3	0.5	-0.2	1.0	-0.5	-0.8
Commuting to job workplace: Walk	0.6	0.6	2.2	-0.5	-0.6	-1.2	0.5	-1.5	0.5	0.1	-0.2	0.9
Eye problems/disorders: Cataract	1.7	2.0	6.2	1.3	1.5	1.1	0.0	-2.3	-0.0	2.5	-1.1	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	8.3	-1.2	-0.6	0.7	-1.8	1.5	-1.1	-2.9	-1.0	-0.4
Medication for cholesterol	0.5	0.8	1.9	-0.1	-0.4	-0.7	0.8	-1.4	-0.8	1.0	0.6	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	6.7	0.9	0.3	-0.9	2.1	2.3	-0.7	-0.2	1.2	2.6
Back pain experienced in last month	0.6	0.9	4.2	-0.9	-0.5	0.1	-0.3	0.3	0.7	-0.1	2.0	1.4
Mineral and other dietary supplements	1.0	1.4	3.2	-1.5	-0.8	0.6	-1.8	0.2	-0.0	-1.7	-0.9	-1.5
Breast cancer (self-reported)	1.6	1.9	4.3	-0.9	-1.2	-2.0	2.1	0.4	-0.9	-1.2	1.7	1.4
Asthma (self-reported)	1.7	3.3	7.0	-1.6	-2.0	-2.6	2.4	-1.2	-2.1	-1.5	-1.5	-0.1
Osteoporosis (self-reported)	3.2	3.9	8.8	1.6	1.6	1.7	-1.9	-0.6	2.8	3.0	2.3	-1.2
Osteoarthritis (self-reported)	1.6	2.1	7.0	0.8	0.2	-1.1	2.3	0.2	-0.1	0.9	2.1	2.6
Medication: Aspirin	1.2	1.6	5.2	1.8	1.6	0.9	-0.2	0.9	0.6	-0.2	2.3	1.2
Medication: Gliclazide	1.1	1.3	2.3	1.3	1.4	0.8	0.3	1.5	-1.2	-0.7	0.9	1.5
Illnesses of father: None of the above (group 1)	0.4	0.5	1.8	0.2	0.1	-0.3	1.3	0.7	0.5	0.6	1.3	0.4
Smoking status: Current	0.8	1.2	4.2	-0.6	-0.7	-0.2	0.8	0.6	-2.0	-1.5	1.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	5.2	-0.2	-0.8	-1.4	1.4	0.0	0.4	0.2	1.4	2.3
Whole body water mass	0.8	4.8	13.9	-1.0	-2.0	-3.4	3.7	-0.7	0.0	0.3	-0.2	3.5
Leg predicted mass (right)	1.1	5.9	16.6	-1.2	-2.2	-4.0	4.1	-0.6	-0.2	0.1	-0.2	3.6
Arm fat mass (left)	0.7	2.9	6.4	-1.7	-2.0	-2.5	2.1	-0.2	-0.6	-1.2	-0.9	2.5
Number of self-reported non-cancer illnesses	1.1	1.9	4.8	-1.8	-1.5	-0.7	0.1	1.1	-2.1	-2.2	-0.4	0.1
Average weekly champagne plus white wine intake	2.2	3.0	5.9	2.1	1.8	0.8	0.5	-1.1	2.4	2.4	0.9	2.3
Miserableness	0.5	0.9	2.3	1.5	1.1	-0.5	1.5	-0.4	-0.4	1.4	-0.1	-0.1
Guilty feelings	0.3	0.5	1.5	0.1	-0.4	-1.2	1.0	-0.0	0.3	0.3	-1.1	-0.4
Wears glasses or contact lenses	0.2	0.3	0.6	0.4	0.6	0.5	0.2	-0.0	0.8	0.2	-0.8	0.6
Ever taken oral contraceptive pill	0.6	0.7	3.6	0.1	0.2	0.6	-0.7	-0.3	-0.6	-0.9	-1.9	-0.3
Hearing aid user	0.8	0.9	2.8	0.8	0.8	0.7	-0.2	1.7	-0.5	-0.4	0.4	-1.6
Mother’s age at death	1.5	1.9	5.6	1.5	1.7	2.4	-1.4	-0.3	0.0	1.2	-0.5	-1.5
Financial situation satisfaction	0.9	1.1	2.6	-1.6	-1.5	-1.5	0.4	0.5	0.2	-1.4	-0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.5	0.5	4.1	0.3	0.2	-0.0	-0.4	2.0	0.4	-0.3	0.2	-0.3
Commuting to job workplace: Public transport	0.5	0.6	3.2	-0.4	-0.4	-0.5	0.7	-1.8	-1.2	0.1	-0.0	-0.4
Eye problems/disorders: Glaucoma	0.9	1.0	1.8	1.3	0.7	-0.3	1.2	1.0	-1.0	-1.0	-0.9	1.2
Medication: Blood pressure	0.4	0.9	3.2	-0.8	-0.6	-0.4	-0.4	1.1	1.8	-0.4	-0.6	1.2
Pain type(s) experienced in last month: Hip pain	1.7	2.2	5.1	-0.1	-0.4	-1.2	1.6	1.9	-1.1	-1.5	1.9	2.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.5	0.4	-0.3	-1.5	2.1	0.8	-0.9	-0.1	-0.0	1.5
High cholesterol (Self-reported)	0.2	0.4	0.8	0.6	0.8	0.8	-0.8	0.9	0.0	-0.3	0.5	0.4
Medication: Bendroflumethiazide	0.3	0.5	2.7	-0.2	-0.3	-0.7	0.7	0.4	0.5	-0.2	-0.1	1.7
Medication: Paracetamol	0.7	1.1	3.1	-1.7	-1.8	-1.4	0.1	0.4	0.4	-0.9	-0.4	0.6
Medication: Lisinopril	1.2	1.6	6.1	-0.9	-1.2	-1.3	1.3	-1.4	0.0	-0.0	0.5	2.5
Medication: Atorvastatin	0.3	0.4	1.1	-0.6	-0.9	-0.7	0.3	0.4	-0.8	-1.1	0.0	0.1
Illnesses of father: High blood pressure	1.0	1.3	3.2	-1.2	-0.5	0.6	-1.3	-1.8	-0.9	-0.8	-1.7	-0.3
Alcohol drinker status: Never	1.6	1.9	5.8	-2.2	-2.0	-1.4	-0.2	-2.4	-0.5	-0.4	-0.3	-0.6
Ever smoked	0.3	0.5	1.7	0.3	-0.2	-0.5	0.8	1.3	-0.8	-0.8	0.2	0.2
Basal metabolic rate	0.8	4.7	12.7	-1.1	-2.0	-3.3	3.5	-0.7	-0.1	0.1	-0.4	3.6
Leg fat percentage (left)	0.4	1.3	5.2	-1.2	-1.1	-1.0	0.5	0.2	1.0	-1.1	-0.9	2.3
Arm fat-free mass (left)	0.9	4.5	13.2	-1.2	-2.1	-3.2	3.2	-0.6	0.5	0.1	0.1	3.6
Number of operations (self-reported)	1.8	2.7	8.2	-1.3	-1.2	-0.8	1.4	0.8	-2.9	-2.7	1.1	1.2
Average weekly beer plus cider intake	2.1	3.0	15.9	0.2	-0.7	-1.4	1.3	4.0	0.3	-1.6	1.5	1.6
Irritability	1.3	2.2	6.0	1.3	0.4	-1.4	2.5	-1.2	-0.9	1.6	1.8	1.4
Risk taking	0.4	0.5	1.0	0.9	0.6	-0.2	0.7	-1.0	0.0	0.4	1.0	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.6	0.6	0.8	1.3	-1.0	0.6	0.0	-1.1	0.1	0.1
Fractured/broken bones in last 5 years	0.8	1.0	2.3	-1.3	-1.4	-1.4	0.1	1.0	-0.3	0.5	0.3	-1.5
Age started oral contraceptive pill	1.6	2.0	6.3	0.6	0.9	1.5	-1.8	-2.5	1.0	1.5	-0.6	-1.2
Diastolic blood pressure, automated reading	0.5	1.5	10.2	0.0	0.1	0.0	-0.5	1.2	3.2	0.4	1.2	0.8
Ever depressed for a whole week	1.4	1.7	3.9	-1.1	-0.4	0.4	-1.9	0.7	-0.7	-1.7	-1.6	-2.0
Unable to work because of sickness or disability	1.2	1.6	4.0	-0.1	-0.4	-1.3	2.0	1.3	-0.3	-0.9	1.5	1.9
Commuting to job workplace: Cycle	0.8	0.9	2.9	1.7	1.6	0.8	-0.8	-0.0	0.7	1.1	0.1	-0.1
Myopia	1.3	1.8	6.1	-0.6	0.1	1.5	-2.4	-2.5	-0.3	0.1	-0.5	-1.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.5	2.1	1.9	1.2	-0.4	-0.1	-0.2	0.8	0.5	-1.2
Cholesterol lowering medication	0.2	0.4	1.3	-1.1	-1.0	-0.5	0.3	-0.6	-0.3	-0.3	0.4	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	4.2	2.0	2.0	1.5	-0.3	-0.7	0.7	0.8	0.2	1.5
Pain experienced in last month	1.1	1.8	5.3	1.8	1.7	1.4	-0.3	-0.1	-0.8	1.4	-0.0	-2.3
Supplements: Calcium	1.6	1.7	4.8	1.3	1.1	0.9	-0.7	-0.8	2.2	2.1	1.1	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.8	0.1	-0.1	-0.1	0.2	-0.4	-0.1	0.1	0.3	0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	1.2	1.2	1.1	-0.7	1.4	1.1	0.3	0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	4.3	-1.5	-1.6	-1.2	1.0	-2.1	-1.6	-0.3	0.4	-0.0
Heart disease (siblings)	0.5	0.6	2.1	-0.4	0.1	0.8	-1.5	-0.3	1.2	-0.0	-1.0	0.0
Alcohol drinker status: Previous	0.2	0.3	0.8	-0.1	0.2	0.4	0.3	0.7	-0.6	-0.9	0.0	0.7
Pack years of smoking	1.5	2.3	7.8	1.4	1.0	0.1	0.9	1.6	1.4	1.3	2.8	1.5
Impedance of whole body	1.8	9.1	24.1	2.9	3.9	4.9	-4.1	1.2	-1.3	-0.3	-1.3	-3.6
Leg fat mass (left)	0.6	2.3	7.4	-1.3	-1.5	-2.0	1.6	-0.2	0.4	-0.9	-1.1	2.7
Arm predicted mass (left)	1.0	4.9	16.8	-0.9	-1.8	-3.2	3.5	-0.5	0.8	0.3	0.2	4.1