Hub : Genes

FAM161B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0580	0.0240	4.4e-04	0.010	0.028	0.006	0.027	-0.002	1.8e-02	0.00021	5.4e-02	0.00024	9.3e-01
2	GTEx	Adipose Subcutaneous	0.0570	0.0270	7.0e-03	0.049	NA	0.012	NA	0.028	6.5e-05	NA	3.1e-02	NA	2.1e-03
3	GTEx	Artery Tibial	0.0703	0.0287	6.1e-04	0.045	NA	0.049	NA	0.063	1.9e-04	NA	9.7e-05	NA	1.0e-05
4	GTEx	Cells EBV-transformed lymphocytes	0.2080	0.0700	9.7e-05	0.156	NA	0.205	NA	0.206	8.9e-06	NA	2.8e-07	NA	2.7e-07
5	GTEx	Cells Transformed fibroblasts	0.0710	0.0320	4.1e-03	0.027	NA	0.013	NA	0.029	3.9e-03	NA	3.6e-02	NA	2.9e-03
6	GTEx	Small Intestine Terminal Ileum	0.2200	0.0960	3.0e-03	-0.001	NA	0.062	NA	0.042	3.3e-01	NA	1.7e-02	NA	4.3e-02
7	GTEx	Testis	0.1540	0.0780	7.4e-03	0.004	NA	0.073	NA	0.002	2.1e-01	NA	3.7e-04	NA	2.5e-01
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0342	0.0212	7.7e-03	0.006	0.013	0.003	NA	0.006	6.0e-02	0.01200	1.4e-01	NA	6.8e-02
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0683	0.0369	5.6e-03	0.015	0.023	0.024	NA	0.019	6.7e-03	0.00120	8.0e-04	NA	2.5e-03
10	TCGA	Brain Lower Grade Glioma	0.0293	0.0175	1.1e-03	0.026	0.019	0.026	NA	0.025	4.8e-04	0.00260	4.9e-04	NA	6.0e-04
11	TCGA	Lung Squamous Cell Carcinoma	0.0291	0.0179	3.6e-03	0.014	0.023	0.001	NA	0.016	8.1e-03	0.00095	2.5e-01	NA	5.4e-03
12	TCGA	Thyroid Carcinoma	0.0580	0.0350	8.0e-04	0.001	0.029	0.023	NA	0.010	2.2e-01	0.00067	2.3e-03	NA	3.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.2	0.3	1.8	0.4	-0.5	-0.7	0.6	0.1	-0.7	-1.3	-0.4	-0.2	0.3	-0.0	-0.0
Bipolar Disorder or Schizophrenia	1.1	2.7	9.1	0.7	-2.1	-2.2	0.2	-0.8	-2.3	-3.0	-1.5	-1.3	-0.4	-0.8	-1.5
Depressed Affect (Nagel 2018)	0.9	2.0	4.4	2.1	1.7	1.7	1.0	1.2	1.0	-1.9	0.9	1.1	0.8	1.0	1.6
Depression (Nagel 2018)	0.2	0.3	1.6	0.7	0.7	1.0	0.2	0.2	1.3	-0.2	0.5	-0.1	0.0	0.0	0.3
Intelligence (Savage-Jansen 2018)	0.4	1.2	6.0	-0.5	-1.7	-2.5	-0.5	-0.7	-0.7	0.2	-0.7	-0.8	-0.5	-0.7	-1.4
Neuroticism (Nagel 2018)	0.3	0.6	2.8	0.4	-0.3	0.1	-0.6	-0.6	0.1	-0.7	-1.1	1.7	-0.8	-0.9	0.4
Schizophrenia (2018)	1.4	3.0	7.8	0.6	-2.3	-2.3	-0.3	-1.1	-2.4	-2.8	-1.6	-1.6	-0.7	-1.0	-1.9
Schizophrenia vs Biploar Disorder	1.2	1.5	8.1	1.0	1.4	2.0	-0.0	0.4	2.8	-0.9	1.0	0.1	0.3	0.6	0.8
Worry (Nagel 2018)	0.9	1.9	3.6	-1.8	-0.8	-0.4	-1.9	-1.7	0.3	0.2	-1.7	1.3	-1.9	-1.9	-0.6
Alzheimer’s Disease (in mother)	0.9	1.0	4.7	2.2	0.1	-0.3	0.7	0.6	-0.0	1.9	0.4	1.3	0.5	0.4	0.6
Alzheimer’s Disease (in father)	0.6	0.6	2.2	-1.3	0.5	0.2	-0.4	0.0	0.7	1.0	1.0	-1.5	-0.2	0.2	-0.8
Alzheimer’s Disease (including proxy)	0.6	0.8	2.7	1.0	0.7	0.3	0.2	0.5	1.3	1.6	1.5	-0.6	0.3	0.6	-0.2
Crohns Disease (2017)	0.1	0.3	1.1	-0.4	-0.4	-0.7	0.4	0.4	0.2	0.8	0.1	-1.0	0.5	0.5	-0.5
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.3	-0.0	0.2	0.6	0.5	-0.3	0.4	-0.2	0.2	0.7	0.5	0.4
Ulcerative Colitis (UC)	0.3	0.6	1.2	1.1	0.5	1.0	0.9	0.5	-0.2	-0.5	0.0	1.0	0.8	0.5	1.1
Major Depression (MDD)	0.3	0.4	1.3	-0.2	0.8	0.9	0.1	0.3	1.1	1.0	0.9	0.0	-0.0	0.2	0.4
Reaction Time	2.4	4.6	6.6	1.6	2.6	1.5	2.0	2.5	2.5	-1.7	2.3	1.4	2.3	2.5	2.5
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.5	-0.8	-1.9	-1.8	-0.9	-1.2	-0.9	-0.7	-1.4	-0.2	-0.8	-1.1	-1.2
Breast Cancer	0.4	1.1	2.2	-0.8	-0.6	0.1	-1.5	-1.4	0.7	-0.2	-0.3	-1.4	-1.4	-1.2	-1.3
Ovarian Cancer	3.6	4.8	9.2	0.8	3.0	1.9	2.3	2.7	1.3	-0.7	2.6	1.0	2.7	2.8	2.5
Prostate Cancer	0.4	0.6	2.9	-0.0	0.1	-0.1	0.9	0.6	-1.7	0.6	-0.4	0.8	0.8	0.5	0.7
Age at First Birth	2.5	3.7	5.9	-2.2	-1.9	-1.6	-2.3	-2.0	-1.9	0.7	-2.3	0.3	-2.3	-2.4	-1.8
Bipolar Disorder (2011)	1.8	1.7	7.3	-1.0	-1.6	-2.5	0.1	-0.5	-2.7	-0.1	-1.1	-0.7	-0.1	-0.4	-1.3
Body Mass Index (BMI) (2010)	3.7	5.0	9.4	2.9	2.2	1.1	3.0	3.0	1.0	-1.1	2.2	-0.7	2.9	3.1	1.7
Coronary Artery Disease (CAD)	0.4	0.4	1.5	0.2	-0.6	-0.8	-0.8	-0.7	-0.6	1.2	-0.1	-0.8	-0.3	-0.3	-0.7
Crohns Disease (2012)	0.4	0.6	3.1	-0.7	-0.4	-1.7	0.8	0.6	-0.1	1.1	0.1	0.3	0.7	0.6	-0.2
Mean Putamen Volume	0.5	0.6	1.5	0.3	-0.1	1.2	-1.2	-0.8	1.0	-0.6	-0.7	-0.4	-0.8	-0.7	-0.1
Fasting Glucose	0.2	0.3	1.3	0.9	0.2	0.2	0.6	0.3	-0.1	-0.4	0.1	-1.1	0.3	0.3	-0.1
HbA1C	0.2	0.2	0.5	-0.0	-0.6	-0.3	-0.7	-0.6	-0.7	-0.2	-0.6	0.1	-0.2	-0.5	-0.3
HDL Cholesterol	0.4	0.6	4.2	-0.6	0.7	0.6	0.2	0.3	1.0	-0.3	-0.0	2.1	0.1	-0.0	0.8
LDL Cholesterol	0.4	0.7	5.0	0.1	-0.9	0.2	0.2	-0.1	0.3	-0.7	-1.0	-2.2	0.2	-0.1	-0.6
Lupus	0.3	0.4	3.0	0.4	0.5	1.7	-0.5	-0.1	0.7	-0.3	0.4	-0.7	-0.1	-0.0	0.1
Neuroticism (2016)	0.2	0.3	2.0	0.8	0.5	0.7	0.3	0.2	1.4	0.1	0.2	0.2	0.1	0.2	0.4
Primary Biliary Cirrhosis	1.0	1.4	5.7	0.0	-0.2	0.5	-0.4	-0.5	-1.4	-2.0	-1.8	2.4	-0.3	-0.7	0.8
Rheumatoid Arthritis	2.1	2.9	8.3	0.9	0.9	-0.6	2.9	2.4	-0.5	0.9	1.6	-0.7	2.5	2.5	1.4
Schizophrenia (2014)	0.6	1.3	7.7	1.1	-1.2	-1.4	0.3	-0.3	-1.2	-2.8	-0.9	-0.5	0.0	-0.2	-0.6
Triglycerides	0.6	1.0	2.4	0.6	0.2	-0.1	1.4	1.4	-1.5	0.4	-0.0	-0.2	1.5	1.4	0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.7	0.6	0.5	1.4	-0.8	-0.5	1.6	1.1	-0.2	-1.1	-0.3	-0.3	-0.3
Ulcerative Colitis	0.3	0.4	2.0	0.4	0.2	0.3	0.7	0.4	-0.3	-0.5	-0.6	1.4	0.6	0.3	0.9
Blood Eosinophil Count	0.4	2.8	4.9	1.5	1.6	1.3	1.8	2.0	-0.8	1.6	2.2	-0.8	2.0	2.1	1.5
Blood Platelet Count	0.2	2.8	8.8	-1.6	1.8	1.8	-0.9	-0.2	3.0	-0.9	2.5	-2.4	-0.6	0.3	-1.2
Blood Red Count	0.4	3.6	8.1	-0.5	-0.6	-1.2	2.0	1.6	-1.9	-0.9	-2.8	2.6	2.6	1.6	2.4
Blood White Count	1.2	9.2	18.6	4.3	2.4	1.8	3.9	3.6	2.6	-0.3	2.9	-0.5	3.9	3.8	2.9
Heel T-Score	0.2	1.5	6.3	-1.7	-1.1	-0.5	-0.7	-0.7	-0.1	1.6	-0.2	-2.5	-0.6	-0.3	-1.8
BMI	2.2	12.6	20.1	4.4	3.4	3.1	4.0	4.1	3.2	-2.1	4.0	-1.2	4.2	4.5	3.1
Height	0.5	9.6	29.9	0.4	-0.9	1.9	-5.5	-4.3	1.4	2.2	-1.8	0.8	-5.0	-4.5	-2.7
Waist Hip Ratio (WHR)	0.3	1.2	3.3	-0.2	-0.7	-1.2	-1.8	-1.6	0.8	-0.1	-0.4	0.3	-1.6	-1.5	-1.1
Systolic Blood Pressure	0.1	0.5	1.5	-1.2	0.5	0.1	0.0	0.2	1.2	-1.0	-0.8	0.8	0.4	0.3	0.6
Smoking Status	0.1	0.2	0.8	0.6	0.1	0.8	-0.2	-0.2	0.9	-0.7	0.2	-0.6	-0.0	0.0	-0.3
Allergy or Eczema	0.2	0.7	1.7	-0.9	1.1	-0.2	0.4	0.8	-0.2	-0.9	0.8	1.3	0.7	0.7	0.8
Cardiovascular Disease	1.1	3.8	10.9	2.2	1.2	1.1	1.7	1.9	3.3	-2.2	1.5	-2.0	2.0	2.2	1.0
Hypothyroidism (self reported)	0.3	0.6	3.2	-0.5	-0.7	-0.9	-0.1	-0.5	-0.7	0.5	-0.1	-1.8	-0.4	-0.4	-1.1
Respiratory disease	0.4	0.9	3.7	-0.6	1.4	0.8	0.2	0.6	1.9	0.6	1.2	0.3	0.5	0.7	0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.9	1.6	0.5	1.4	1.1	0.9	0.8	-0.0	1.0	-1.7	1.1	1.1	0.5
Lung FEV1/FVC ratio	0.9	4.6	10.7	3.3	-1.4	-1.7	2.5	1.7	-2.6	-3.1	-1.5	1.5	2.3	1.4	1.8
Lung FVC	0.5	2.7	12.3	-3.5	-0.5	-2.1	1.1	0.5	-2.6	1.8	-0.9	1.6	0.7	0.2	0.5
Neuroticism	0.2	0.5	1.6	1.1	0.9	0.7	0.4	0.7	0.3	-0.3	0.2	1.3	0.5	0.5	1.0
Chronotype (morning person)	1.2	2.9	7.6	0.5	0.1	1.9	-2.2	-1.8	2.8	0.1	0.5	-1.8	-2.4	-1.8	-1.6
Hair Pigment	0.1	4.1	9.5	-1.5	-2.2	-1.5	-1.6	-2.1	-2.4	3.1	-1.9	-1.1	-2.1	-2.3	-2.1
Tanning	0.1	1.0	2.7	0.5	1.5	1.1	-0.3	0.5	0.5	-1.4	1.4	1.6	0.0	0.4	1.0
Hand grip strength (left)	0.3	0.7	3.1	0.5	1.1	-0.8	-0.3	0.3	0.7	1.2	1.0	1.8	-0.3	-0.1	0.1
Number of treatments/medications taken	1.5	2.8	10.2	0.9	1.8	1.6	0.5	1.1	3.2	-0.2	2.3	-2.7	0.8	1.3	-0.1
Average weekly spirits intake	0.4	0.5	1.6	-0.4	0.3	0.8	-0.9	-0.5	0.9	0.3	0.4	-1.3	-0.7	-0.3	-0.7
Sensitivity / hurt feelings	0.2	0.3	1.2	1.0	-0.5	0.3	0.1	-0.1	-0.7	0.1	-1.1	0.9	-0.0	-0.3	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	0.9	0.6	0.6	0.3	0.5	0.4	-0.5	0.4	-0.1	0.4	0.5	0.4
Hearing difficulty/problems: Yes	0.4	0.5	3.3	0.9	0.1	-0.1	0.2	0.4	-0.2	0.0	-0.4	1.8	0.5	0.2	1.2
Relative age of first facial hair	0.6	1.3	5.1	1.5	-0.5	-0.5	1.0	0.5	-2.3	-2.1	-0.4	-0.2	0.9	0.6	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	4.9	-0.7	-0.2	0.0	-0.5	-0.3	0.6	-1.0	-0.4	-2.2	-0.3	-0.1	-1.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.1	-0.1	0.6	1.5	-0.3	0.0	1.2	-1.4	-0.2	0.8	-0.3	-0.2	0.6
Ever had hysterectomy (womb removed)	0.8	0.9	3.1	-1.0	-1.3	-1.3	0.3	-0.5	-1.4	0.8	-1.8	0.6	-0.2	-0.6	-0.2
Systolic blood pressure, automated reading	0.1	0.3	1.1	-0.8	0.1	-0.4	-0.1	0.1	-0.4	-0.7	-1.1	1.0	0.1	-0.0	0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.2	0.8	-0.5	-1.5	0.9	0.7	-0.5	-1.0	-0.4	0.3	0.9	0.7	0.3
Angina	0.4	0.5	1.7	-0.0	1.1	1.2	-0.1	0.4	1.3	-0.4	1.1	-0.1	0.2	0.5	0.3
Medication for hormone replacement therapy	0.9	1.1	2.5	0.3	0.5	1.5	0.6	0.3	1.4	-1.6	-1.0	1.5	0.4	0.1	1.3
Vitamin and mineral supplements	2.0	2.7	8.7	1.5	1.2	2.5	0.9	1.1	2.4	-0.9	1.0	-3.0	1.3	1.5	0.5
Supplements: Zinc	0.7	0.7	2.2	1.3	1.0	1.0	0.5	0.5	0.1	-1.5	1.4	0.1	0.2	0.5	0.3
Medication: Co-codamol	0.8	0.9	7.2	0.8	0.2	0.1	0.5	0.3	-0.2	-0.9	1.0	-2.7	0.4	0.6	-0.7
Medication: Metformin	1.1	1.5	4.1	2.0	0.9	1.6	1.3	1.0	1.5	0.1	0.8	0.1	1.2	1.1	1.5
Diabetes (father)	0.2	0.2	1.0	-0.5	-0.1	-0.9	-0.2	0.1	-1.0	-0.1	-0.2	0.6	-0.1	-0.1	-0.0
Diabetes (mother)	0.8	1.0	6.6	0.5	0.3	1.0	1.0	0.7	0.3	-2.6	0.1	-0.9	0.9	0.8	0.4
Severe depression (siblings)	0.2	0.3	1.0	-0.0	0.1	0.8	-0.2	-0.0	0.4	-0.0	-0.8	1.0	0.0	-0.1	0.8
Pack years adult smoking proportion	1.0	1.5	5.1	1.3	1.6	2.3	0.7	1.1	1.4	-0.9	1.3	-0.7	0.9	1.1	0.7
Impedance of leg (right)	3.1	14.8	29.7	-3.2	-3.7	-2.5	-5.0	-5.1	0.5	2.5	-3.9	-0.7	-5.4	-5.4	-4.1
Leg fat-free mass (left)	1.1	5.8	15.6	4.0	2.3	2.6	2.4	2.6	1.4	-1.1	2.3	0.1	2.7	2.8	2.3
Trunk fat percentage	0.7	2.8	11.9	3.5	0.8	2.1	0.5	0.7	2.9	0.3	1.1	-2.0	0.9	1.1	0.4
Hand grip strength (right)	0.2	0.5	2.5	0.5	0.9	-0.6	-0.4	-0.1	0.4	0.1	1.0	1.6	-0.5	-0.3	-0.0
Townsend deprivation index at recruitment	1.5	2.2	3.5	1.8	1.6	1.4	1.9	1.8	0.5	-0.2	1.3	-0.2	1.8	1.8	1.6
Current tobacco smoking	0.6	1.0	2.5	1.6	0.5	0.5	1.4	1.1	0.5	-0.9	0.6	0.0	1.3	1.2	0.9
Average weekly fortified wine intake	1.8	2.1	7.0	-2.7	-0.8	-1.6	-1.6	-1.5	-0.5	1.3	-0.1	-0.7	-1.7	-1.4	-1.9
Maternal smoking around birth	0.4	0.6	4.3	-0.6	0.4	0.6	-0.4	-0.2	1.3	2.1	-0.4	0.1	-0.1	-0.1	0.2
Fed-up feelings	1.0	1.9	3.8	2.0	1.8	1.3	0.9	1.4	1.3	-1.2	1.3	1.6	0.8	1.1	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.9	1.6	1.1	1.7	1.0	1.0	1.0	0.1	0.4	0.5	1.0	0.9	1.4
Relative age voice broke	0.6	1.0	3.3	0.8	0.6	0.4	1.3	1.0	-0.8	-1.8	0.8	-0.6	1.2	1.1	0.7
Taking other prescription medications	0.5	0.7	4.3	0.4	0.1	0.2	-0.5	-0.2	1.8	-0.1	0.3	-2.1	-0.3	-0.0	-0.7
Age when periods started (menarche)	0.2	0.4	1.6	-0.7	-0.8	-0.7	-0.2	-0.4	-1.3	-0.6	-0.4	-0.9	-0.4	-0.5	-0.6
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	5.5	-0.5	1.4	1.0	0.7	0.9	1.8	-1.5	0.0	2.3	0.7	0.4	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.5	-1.9	-1.7	-1.7	-1.3	-1.3	-1.4	1.3	-1.3	-0.8	-1.2	-1.3	-1.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.9	0.3	0.8	1.0	0.3	0.4	0.6	-0.3	0.3	-0.2	0.1	0.3	0.3
Qualifications: CSEs or equivalent	0.3	0.4	1.6	-1.3	-0.5	-0.4	-0.5	-0.4	-1.1	0.8	-0.7	-0.3	-0.3	-0.3	-0.4
Serious illness, injury or assault to yourself	1.5	1.8	2.4	1.5	1.2	0.9	1.5	1.5	1.4	-1.5	1.5	-0.8	1.5	1.5	0.9
High blood pressure	0.8	2.3	5.6	1.3	1.2	0.3	1.5	1.6	2.4	-0.9	1.7	-1.8	1.6	1.8	0.6
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.6	-0.2	1.4	0.4	1.4	1.5	-0.7	-0.5	1.0	1.3	1.6	1.5	1.5
Multivitamins +/- minerals	0.9	1.1	7.4	-0.7	-0.6	-1.8	-0.4	-0.5	-0.4	0.7	-0.2	2.7	-0.6	-0.7	0.1
Stomach or abdominal pain in last month	0.6	0.7	8.2	0.1	0.1	-0.2	0.0	0.0	0.5	-2.9	0.2	0.2	0.0	0.1	0.0
Supplements: Glucosamine	0.4	0.5	2.3	-0.2	0.3	0.3	-0.1	-0.2	-0.0	1.5	0.1	1.5	-0.3	-0.4	0.7
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.3	-0.8	0.1	-0.1	-0.9	-0.4	1.2	0.0	0.2	-1.8	-0.7	-0.3	-1.6
Medication: Atenolol	1.7	2.1	7.8	-0.5	1.6	1.5	0.5	0.9	2.8	0.8	2.0	-2.0	0.8	1.2	0.5
Medication: Levothyroxine sodium	1.0	1.7	2.7	-1.2	-1.4	-0.8	-1.6	-1.7	-0.8	0.1	-1.2	-1.3	-1.6	-1.6	-1.6
Sitting height	0.2	1.7	3.6	-0.9	-0.7	0.3	-1.5	-1.6	0.3	1.3	-1.8	1.9	-1.5	-1.9	-0.4
Chronic bronchitis/emphysema (father)	0.3	0.3	1.1	-1.0	-0.2	-0.8	-0.5	-0.6	0.1	0.6	-0.0	-0.2	-0.5	-0.5	-0.6
High blood pressure (mother)	1.2	1.7	5.1	0.5	1.1	1.6	1.0	1.1	2.3	-0.8	1.2	-1.5	1.4	1.6	0.7
Body mass index (BMI)	1.7	7.4	15.2	3.9	2.3	2.7	3.0	3.1	2.2	-1.4	2.4	-1.0	3.3	3.4	2.5
Impedance of leg (left)	2.5	12.2	24.1	-2.9	-3.3	-2.3	-4.6	-4.6	0.3	1.9	-3.4	-0.9	-4.9	-4.9	-3.9
Leg predicted mass (left)	1.1	5.9	15.9	4.0	2.4	2.7	2.4	2.6	1.4	-1.0	2.4	0.1	2.7	2.9	2.3
Trunk fat mass	0.8	3.5	15.8	4.0	1.2	2.7	0.7	1.1	2.7	-0.2	1.2	-1.7	1.2	1.4	0.8
Waist circumference	1.1	3.9	14.1	3.8	1.5	2.3	1.4	1.6	2.4	-1.6	1.5	-1.0	1.8	1.9	1.4
Number of incorrect matches in round	0.5	0.9	2.1	-0.5	-1.4	-0.6	-0.5	-0.9	-1.4	1.0	-1.4	0.8	-0.6	-0.8	-0.2
Past tobacco smoking	0.2	0.4	0.8	-0.4	0.4	-0.5	0.8	0.9	0.3	0.4	0.7	0.0	0.9	0.9	0.6
Alcohol usually taken with meals	1.7	2.7	5.1	2.1	0.8	0.0	2.3	2.0	-1.6	-1.0	1.0	1.2	2.2	1.9	1.8
Nervous feelings	0.4	0.7	2.2	-0.4	-0.7	-1.5	-0.2	-0.5	-0.6	-1.2	-1.2	1.2	-0.5	-0.8	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	4.0	1.4	1.8	1.6	1.1	1.3	2.0	-1.2	1.4	0.7	1.3	1.4	1.9
Hearing difficulty/problems with background noise	0.5	0.7	2.9	1.0	-0.3	-1.2	0.7	0.7	-0.3	-0.3	-0.4	1.7	0.8	0.4	1.0
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	-0.4	-0.9	-1.3	-0.9	-0.8	-0.4	-0.5	-0.2	0.4	-1.0	-0.9	-0.8
Had menopause	1.5	1.9	4.1	-1.5	-0.6	0.8	-2.0	-1.7	0.8	1.8	-1.0	-0.6	-1.8	-1.6	-1.2
Had other major operations	4.0	4.9	8.4	2.5	2.3	0.9	2.9	2.8	1.3	-1.0	2.3	1.1	2.7	2.8	2.5
Forced vital capacity (FVC)	0.4	1.6	4.0	-1.6	-0.6	-1.3	-0.4	-0.5	-1.9	1.7	-1.3	2.0	-0.5	-0.9	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	2.5	-1.0	-0.8	-0.9	-0.2	-0.3	-0.8	1.1	-0.1	-1.6	-0.1	-0.1	-1.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.3	0.6	1.0	0.2	1.1	1.3	0.2	-1.2	0.4	1.5	1.1	0.9	1.4
Qualifications: None of the above	1.6	3.5	19.9	1.0	1.7	3.6	-0.7	-0.4	4.5	-1.0	1.3	-1.3	-0.8	-0.2	-0.0
Financial difficulties in last 2 years	0.3	0.4	1.0	-0.3	0.8	0.4	0.5	0.8	0.2	-0.6	0.7	-0.4	0.8	1.0	0.4
Mouth/teeth dental problems	0.5	0.8	2.7	0.1	-1.1	-1.2	-0.1	-0.6	-1.6	1.4	-0.9	0.5	-0.6	-0.8	-0.3
Heart attack	1.1	1.4	3.6	1.9	1.0	1.4	1.3	1.3	0.6	-0.5	1.0	0.5	1.4	1.3	1.3
Allergy	0.4	1.0	1.7	0.9	-1.2	-0.1	-1.2	-1.2	0.0	-0.4	-1.2	-0.6	-1.3	-1.3	-1.0
Pain all over the body in last month	0.3	0.3	1.5	0.0	0.2	0.0	0.1	-0.0	0.9	0.9	0.2	-1.2	-0.1	-0.1	-0.5
Diabetes (self-reported)	1.4	2.2	3.8	2.0	1.2	2.0	1.8	1.5	0.8	-0.6	1.4	-0.3	1.7	1.7	1.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	-0.3	-0.3	-0.5	-0.7	-0.6	0.2	0.1	-0.4	0.1	-0.7	-0.7	-0.6
Medication: Ramipril	0.7	0.9	3.1	0.5	0.8	1.3	0.1	0.4	1.8	-0.0	1.2	-1.6	0.3	0.6	-0.1
Medication: Simvastatin	1.1	1.6	3.6	1.9	0.6	0.2	1.6	1.5	1.1	-1.9	0.7	0.2	1.5	1.3	1.1
Fluid intelligence score	0.3	0.5	2.0	-0.6	-1.1	-1.4	-0.4	-0.6	-0.5	-1.0	-0.6	0.5	-0.3	-0.5	-0.3
Illnesses of siblings	0.5	0.7	1.5	0.2	1.2	1.2	0.5	0.8	-0.4	0.4	1.1	0.9	0.6	0.7	1.1
Neuroticism score	0.2	0.3	2.1	0.9	0.1	0.0	0.1	0.2	-0.1	-0.3	-0.6	1.5	-0.0	-0.1	0.6
Weight	1.0	5.0	17.5	4.2	2.0	2.9	1.6	2.0	2.3	-1.0	2.0	-0.8	2.0	2.2	1.6
Impedance of arm (right)	1.9	9.0	14.7	-2.2	-2.7	-2.1	-3.7	-3.7	0.2	3.4	-2.2	-2.2	-3.8	-3.7	-3.8
Arm fat percentage (right)	1.1	4.3	13.4	3.7	1.3	2.1	1.6	1.7	2.5	0.1	1.7	-2.7	2.0	2.2	0.9
Trunk fat-free mass	0.4	2.5	7.2	2.7	1.8	2.3	1.2	1.5	0.6	-1.2	1.4	0.9	1.4	1.5	1.6
Hip circumference	1.0	4.3	15.6	3.9	1.5	2.3	1.9	1.9	2.3	-0.9	1.6	-1.6	2.1	2.2	1.3
Time employed in main current job	0.4	0.5	1.6	-0.4	-0.9	-0.5	-0.4	-0.6	-0.3	-1.1	-1.2	0.7	-0.4	-0.7	-0.1
Alcohol intake versus 10 years previously	1.3	1.9	6.8	1.8	0.9	1.3	1.3	1.1	2.6	-0.4	1.2	-1.6	1.1	1.3	0.3
Father’s age at death	0.3	0.5	2.4	0.3	-0.3	-0.8	-0.5	-0.4	-1.6	-0.5	-0.1	1.0	-0.6	-0.6	-0.1
Worrier / anxious feelings	0.1	0.2	0.9	-0.6	-0.3	-0.1	-0.3	-0.2	-0.3	0.6	-0.5	0.9	-0.3	-0.3	0.3
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.3	6.8	2.3	1.8	1.3	1.9	1.9	2.6	-1.0	2.2	-0.7	1.9	1.9	1.5
Falls in the last year	0.6	0.8	3.1	0.3	0.7	0.1	-0.2	0.2	1.7	0.6	1.4	-1.8	0.1	0.4	-0.7
Hair/balding pattern: Pattern 3	0.6	0.9	2.3	1.0	0.9	1.0	0.7	0.9	-0.2	-0.7	1.0	-1.5	1.0	1.2	0.2
Number of live births	3.5	4.9	7.1	1.6	2.6	2.2	2.3	2.7	1.3	-2.5	2.1	0.8	2.5	2.6	2.5
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	7.5	-1.0	-1.3	-2.0	0.0	-0.3	-2.7	1.0	-2.1	2.1	-0.1	-0.8	0.2
Pulse rate	0.3	0.6	1.3	0.5	0.3	0.1	1.2	0.8	-0.3	-0.8	0.2	0.7	1.2	0.8	1.1
Happiness	1.2	1.4	4.0	1.1	-1.1	-1.9	0.1	-0.2	-1.7	-1.0	-1.5	2.0	0.1	-0.4	0.4
Noisy workplace	0.2	0.2	0.7	-0.2	0.7	0.4	-0.0	0.4	0.4	0.8	-0.2	0.6	0.1	0.1	0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.1	-0.4	0.2	-1.3	1.0	0.8	-1.5	-0.6	1.1	0.4	0.9	0.9	0.2
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	3.9	1.8	1.4	0.5	2.0	1.8	0.1	-1.7	1.3	1.4	1.7	1.6	1.7
Mouth/teeth dental problems: Dentures	0.4	0.7	2.2	1.5	0.3	1.4	0.7	0.7	0.3	-0.8	-0.1	-0.6	0.9	0.7	0.6
Asthma	0.3	0.6	2.7	-1.2	0.6	-0.4	0.0	0.2	0.5	1.6	1.4	-0.6	0.1	0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.0	1.2	1.5	1.1	1.6	1.7	1.3	-1.2	1.7	-0.1	1.5	1.7	1.2
Medication: Cholesterol lowering	0.5	0.7	2.2	1.5	0.3	0.9	1.1	1.0	-0.0	-0.5	0.3	-0.6	1.0	1.0	1.0
Depression (self-reported)	0.6	0.8	3.1	-0.0	-0.6	0.1	-0.9	-0.7	1.3	0.8	-0.2	-1.8	-0.8	-0.5	-1.0
Medication: Lansoprazole	1.0	1.1	7.5	0.6	-0.0	0.3	-1.4	-0.8	2.7	0.7	0.1	-0.2	-1.1	-0.8	-0.6
Prospective memory result	0.5	0.6	3.4	1.1	0.6	1.0	0.2	0.3	-0.1	-1.9	0.4	-0.5	0.2	0.4	0.4
Lung cancer (father)	1.3	1.5	4.7	-0.5	-1.4	-0.4	-1.0	-1.3	0.4	2.0	-2.2	0.3	-1.2	-1.3	-0.8
Illnesses of mother	0.6	0.7	1.7	-0.6	-0.6	-0.7	-1.0	-1.1	-0.6	-0.3	-0.8	0.8	-1.3	-1.3	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	9.4	-0.4	-1.0	-2.0	0.7	0.3	-3.1	0.9	-1.8	2.2	0.5	-0.1	0.8
Pulse wave Arterial Stiffness index	0.4	0.5	1.7	-1.1	0.0	0.1	-1.3	-0.9	0.8	-0.1	0.0	0.3	-0.9	-0.8	-0.5
Impedance of arm (left)	1.5	6.8	12.0	-1.8	-2.3	-1.7	-3.4	-3.4	0.3	2.6	-2.0	-1.6	-3.5	-3.4	-3.2
Arm fat mass (right)	1.2	4.9	16.0	4.0	1.8	2.6	1.8	2.1	2.5	-0.3	1.8	-1.6	2.2	2.4	1.5
Trunk predicted mass	0.4	2.6	7.4	2.7	1.8	2.2	1.2	1.5	0.6	-1.3	1.4	0.9	1.4	1.5	1.6
Standing height	0.3	3.0	9.0	0.7	-0.7	0.7	-3.0	-2.4	-0.2	1.1	-1.2	0.6	-2.8	-2.6	-1.7
Length of working week for main job	0.5	0.5	3.0	-0.7	0.7	0.5	-0.1	0.3	1.0	1.7	0.7	-0.3	0.1	0.3	-0.0
Exposure to tobacco smoke at home	3.2	3.6	14.1	1.8	1.8	1.6	1.7	1.6	2.0	-3.8	1.3	0.8	1.6	1.7	1.6
Breastfed as a baby	0.3	0.4	2.0	-0.3	-0.0	-0.3	-0.7	-0.4	0.7	-0.6	0.7	-1.4	-0.5	-0.2	-0.8
Tense / ‘highly strung’	0.9	1.5	4.2	-0.0	-0.3	-0.2	-1.6	-1.5	2.0	1.5	-0.1	0.3	-1.9	-1.6	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.4	-0.3	0.8	-0.7	-0.7	0.8	0.3	-0.9	-0.6	-0.8	-0.8	-0.4
Hair/balding pattern: Pattern 4	1.0	2.5	5.1	1.6	1.4	1.5	1.8	1.7	1.3	-0.2	0.7	1.8	1.9	1.7	2.2
Birth weight of first child	0.2	0.4	1.2	0.4	-1.1	-0.5	-0.6	-0.6	-0.3	0.4	-0.6	-0.8	-0.3	-0.5	-0.6
Peak expiratory flow (PEF)	1.0	2.3	12.0	-0.1	-1.1	-1.2	0.7	0.2	-3.5	0.2	-2.7	1.9	0.8	-0.1	1.1
Pulse wave reflection index	2.7	3.4	8.1	-2.8	-1.0	-1.3	-2.6	-2.2	0.7	0.4	-0.9	-0.3	-2.6	-2.3	-2.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	1.0	0.1	0.0	0.7	0.6	-0.7	-1.1	0.2	-1.1	0.5	0.4	-0.3
Loud music exposure frequency	0.9	1.0	3.3	1.7	0.4	1.0	0.8	0.7	-0.7	-1.8	-0.1	-0.1	0.9	0.8	1.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	8.1	-0.8	-1.6	-2.1	0.3	-0.3	-2.9	-1.3	-0.9	0.0	-0.0	-0.3	-0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	0.7	0.8	-0.2	0.5	0.8	1.0	-1.2	0.6	0.7	0.8	0.9	0.7
Blood clot in the leg (DVT)	0.2	0.2	0.6	-0.1	-0.1	-0.6	0.8	0.5	0.3	-0.5	0.2	-0.5	0.7	0.7	0.1
Medication: Paracetamol	0.9	1.5	3.7	0.9	0.7	0.2	1.4	1.4	-0.3	-1.8	1.2	-1.9	1.4	1.6	0.1
Headache pain in last month	1.0	1.7	3.9	0.1	1.6	0.0	1.2	1.5	0.8	-2.0	2.0	0.0	1.5	1.7	0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.7	-0.8	-0.5	-1.4	-0.4	-0.7	-0.5	0.9	-0.6	1.9	-0.6	-0.8	-0.4
Glaucoma (self-reported)	0.4	0.5	1.3	-0.3	0.2	-1.0	0.7	0.5	-1.0	0.9	-0.0	1.1	0.6	0.3	0.8
Gout (self-reported)	0.4	0.6	2.2	0.1	-0.6	0.1	0.0	-0.0	-1.5	-1.4	-1.4	0.4	0.2	-0.1	0.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	3.6	-0.8	-1.1	-0.9	-1.0	-1.1	-0.4	0.4	-0.6	-1.9	-1.2	-1.1	-1.6
Medication: Amlodipine	0.7	1.0	3.2	0.5	1.0	0.9	0.4	1.0	1.0	-1.8	0.7	-0.1	1.2	1.2	1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.6	-1.0	-0.1	-0.1	-0.6	-0.5	0.1	-0.0	-0.0	-1.3	-0.6	-0.4	-0.8
Birth weight	1.3	2.9	6.0	2.0	-0.2	-0.1	2.4	1.9	-2.5	-1.4	-1.1	0.5	2.3	1.7	2.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.9	-0.6	1.1	1.1	-0.2	-0.0	0.8	0.5	0.7	1.7	-0.3	-0.1	0.8
High blood pressure (siblings)	0.5	0.7	2.5	-0.1	-1.4	-0.9	-0.6	-0.8	-0.4	0.7	-1.6	-0.4	-0.6	-0.7	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.3	5.0	-1.0	-0.3	-1.6	0.4	0.2	-2.2	1.5	-0.8	1.8	0.2	-0.2	0.5
Body fat percentage	0.8	3.1	12.1	3.5	0.9	2.3	0.6	0.8	3.1	0.0	1.1	-2.1	1.0	1.2	0.6
Leg fat percentage (right)	0.8	2.9	11.4	3.3	0.7	2.4	0.5	0.7	3.4	-0.3	0.6	-1.7	0.8	0.9	0.8
Arm fat-free mass (right)	0.6	3.1	8.1	2.8	1.7	2.0	1.6	1.8	0.7	-1.6	1.5	1.0	1.8	1.8	1.8
Exposure to tobacco smoke outside home	1.4	1.8	3.4	0.8	1.7	1.3	1.6	1.7	0.7	-0.1	1.7	0.3	1.6	1.8	1.2
Comparative body size at age 10	0.3	0.7	1.5	-0.4	0.8	0.6	0.6	0.9	1.2	0.8	0.7	-1.2	1.0	1.2	0.1
Number of full brothers	0.2	0.3	1.0	-0.1	-1.0	-0.8	-0.2	-0.6	-0.1	0.2	-0.5	-0.5	-0.4	-0.5	-0.7
Worry too long after embarrassment	0.7	1.1	4.2	0.2	-1.5	-1.3	-0.0	-0.3	-2.0	1.1	-1.8	0.7	0.1	-0.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.8	-0.1	-0.6	-0.2	-0.5	-0.8	1.4	-0.2	-0.7	-0.3	-0.8	-0.9	-0.6
Wheeze or whistling in the chest in last year	0.6	1.1	3.9	-0.0	1.5	0.9	-0.1	0.3	2.0	-0.6	2.0	-1.1	0.2	0.6	-0.2
Number of children fathered	2.8	3.1	6.3	1.9	1.2	1.1	2.5	2.2	-0.9	-0.8	0.9	0.6	2.5	2.2	2.5
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.0	-0.9	-0.3	0.3	-1.7	-1.4	0.9	0.1	-0.4	0.3	-1.7	-1.5	-0.9
Age at first live birth	0.4	0.8	1.8	-0.6	-0.9	-1.1	-1.3	-1.1	-0.0	-0.4	-0.6	0.6	-1.1	-1.2	-0.5
Pulse wave peak to peak time	0.3	0.4	1.5	1.2	0.0	0.2	1.0	0.7	-0.6	0.1	-0.0	-0.4	0.7	0.6	0.4
Health satisfaction	7.0	9.1	14.7	3.0	2.9	1.5	3.8	3.6	0.4	-3.3	2.5	2.8	3.6	3.4	3.5
Shortness of breath walking on level ground	1.2	1.4	7.7	1.7	0.4	0.4	1.0	0.9	1.0	-2.8	1.1	-0.3	0.9	0.8	0.6
Qualifications: College or University degree	0.7	2.1	12.5	-0.7	-1.5	-2.7	0.8	0.2	-3.5	-0.2	-1.0	0.5	0.6	0.1	-0.0
Eye problems/disorders: None of the above	0.4	0.5	1.6	-1.3	0.4	-0.2	-0.9	-0.4	-0.4	1.2	0.6	0.7	-0.7	-0.4	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.5	-0.8	-0.0	-0.2	-1.2	-0.9	0.2	1.2	0.2	-0.3	-1.1	-0.8	-0.7
Emphysema/chronic bronchitis	0.9	1.0	3.9	1.1	0.2	0.6	0.9	0.7	0.5	-1.7	0.6	-2.0	0.8	0.9	-0.3
Medication for pain relief, constipation, heartburn	1.4	2.4	4.9	-0.7	-1.7	-1.4	-1.4	-1.7	-0.7	2.2	-1.9	1.8	-1.6	-1.9	-0.6
Neck or shoulder pain in last month	1.1	1.6	6.2	0.6	1.5	1.6	0.5	0.9	1.8	-2.5	0.9	0.2	0.7	0.8	1.0
Medication: Blood pressure	0.4	0.7	3.1	0.3	0.6	1.2	0.3	0.6	0.7	-0.0	1.1	-1.8	0.5	0.9	0.2
Angina (self-reported)	0.4	0.5	1.9	-0.1	1.0	1.3	-0.3	0.3	1.4	0.2	0.8	0.1	0.1	0.4	0.4
Migraine (self-reported)	1.2	1.4	3.6	0.6	0.8	-1.0	1.5	1.5	-1.1	-1.9	1.5	-0.0	1.2	1.4	0.4
Medication: Ibuprofen	1.5	1.7	2.9	1.0	1.5	1.2	1.6	1.6	0.7	-1.1	1.7	0.5	1.4	1.6	1.3
Medication: Allopurinol	0.7	1.0	3.1	1.1	0.5	1.8	0.7	0.8	-1.0	-1.3	-0.0	0.4	0.9	0.9	1.0
Medication: Omeprazole	1.7	2.0	3.4	1.7	1.2	0.4	1.8	1.9	0.5	-1.8	1.0	0.1	1.8	1.7	1.6
Medication: Seretide 50 evohaler	0.3	0.3	1.1	1.1	0.3	0.6	0.8	0.6	-0.2	-0.2	0.0	0.1	0.8	0.6	0.7
Mean time to correctly identify matches	1.6	3.1	5.2	0.8	2.3	1.7	1.4	1.9	2.0	-1.6	2.1	0.8	1.8	2.0	2.0
Heart disease (mother)	0.4	0.5	1.3	-0.3	0.1	-1.1	0.8	0.8	-0.7	0.5	0.5	-0.8	0.7	0.7	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	-0.1	0.0	0.2	-0.6	-0.5	-0.1	-0.6	-0.2	-0.6	-0.4	-0.3	-0.6
Whole body fat mass	1.0	4.0	15.9	4.0	1.3	2.8	1.2	1.4	2.7	-0.5	1.3	-1.8	1.6	1.7	1.1
Leg fat mass (right)	0.9	3.3	14.0	3.7	1.0	2.4	1.0	1.2	2.7	-0.6	1.0	-1.6	1.4	1.5	1.0
Arm predicted mass (right)	0.6	3.1	9.5	3.1	1.5	1.9	1.6	1.8	0.6	-1.7	1.2	1.1	1.8	1.8	1.9
Pulse rate, automated reading	1.9	6.3	11.6	3.2	1.5	0.5	3.1	2.8	0.4	-3.0	0.6	2.9	3.2	2.5	3.4
Alcohol intake frequency.	1.8	4.3	8.8	3.0	1.4	2.1	2.8	2.2	1.8	-1.8	1.4	-1.0	2.4	2.3	1.6
Comparative height size at age 10	0.9	5.1	14.0	-0.7	-1.2	-0.1	-3.7	-3.0	0.2	1.5	-0.6	-0.9	-3.6	-3.0	-3.2
Number of full sisters	1.8	2.1	4.7	1.1	1.6	2.2	1.6	1.7	0.8	-1.0	1.2	-0.8	1.6	1.8	1.4
Suffer from ‘nerves’	0.7	1.1	2.4	-1.0	-0.5	-1.5	-1.3	-1.0	-0.3	-1.5	-0.7	1.0	-1.2	-1.2	-0.7
Overall health rating	4.3	9.3	14.8	3.8	2.8	2.3	3.5	3.7	1.8	-3.8	2.4	-0.9	3.6	3.6	2.7
Chest pain or discomfort	0.9	1.2	2.0	1.3	0.8	0.4	1.1	1.3	1.3	-1.1	1.2	-0.8	1.4	1.4	0.8
Had major operations	0.6	0.7	1.9	0.7	0.5	0.8	1.4	1.0	0.3	-0.7	0.3	0.3	1.1	1.0	1.2
Age at last live birth	0.2	0.3	1.1	-0.2	0.6	0.3	-0.1	0.3	0.4	-1.0	0.5	0.7	0.2	0.3	0.7
Family relationship satisfaction	1.9	2.3	8.6	1.5	0.8	-0.2	1.2	1.2	-1.8	-1.8	0.1	2.9	1.3	1.0	2.0
Leg pain on walking	0.8	1.0	4.1	1.5	0.5	0.3	1.1	0.7	0.2	-2.0	0.9	0.6	0.9	0.9	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.3	-0.5	0.5	1.1	-0.4	-0.1	0.5	-0.8	0.7	-1.5	-0.2	-0.0	-0.7
Commuting to job workplace: Car/motor vehicle	1.2	1.3	3.7	1.9	1.1	0.4	1.3	1.3	0.8	-0.3	1.5	-0.4	1.2	1.5	0.6
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	4.9	-1.4	-2.2	-1.5	-1.8	-2.1	-0.9	2.1	-1.9	-0.6	-1.9	-2.1	-2.0
Medication: Aspirin	0.3	0.3	1.3	-0.5	0.8	1.2	-0.2	0.1	0.6	-0.4	0.9	-0.6	-0.1	0.2	-0.1
Supplements: Vitamin C	0.6	0.8	1.9	-1.4	-0.9	-0.6	-0.5	-1.0	-1.1	-0.2	-0.8	0.7	-1.0	-1.1	-0.6
Knee pain experienced in last month	0.6	0.9	3.3	0.4	0.1	1.0	-1.3	-0.8	1.8	0.7	0.4	-0.9	-1.2	-0.8	-0.9
Hypertension (Self-reported)	0.7	1.9	6.3	1.3	1.2	0.3	1.2	1.5	2.5	-0.7	1.5	-1.4	1.4	1.6	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.2	-0.2	-1.5	-1.5	-0.7	-0.8	-1.0	-1.0	-1.4	0.0	-0.8	-0.9	-0.8
Illnesses of father: Heart disease	0.6	0.8	5.8	0.3	-0.9	-2.4	0.2	-0.1	-1.1	-0.4	0.1	-0.8	-0.0	-0.1	-0.8
Illnesses of siblings: Diabetes	0.3	0.4	1.0	0.7	0.1	0.1	1.0	0.7	0.6	-0.9	0.2	-0.3	0.9	0.8	0.4
Smoking status: Previous	0.9	1.4	3.3	-0.2	-1.3	-0.3	-1.3	-1.6	-0.9	-0.2	-1.8	-0.0	-1.5	-1.7	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.2	-0.9	-1.1	-1.3	-1.3	-1.7	-0.8	1.2	-1.1	0.0	-1.7	-1.8	-1.5
Whole body fat-free mass	0.8	4.4	12.1	3.5	2.2	2.5	1.9	2.2	0.9	-1.2	1.9	0.7	2.2	2.3	2.1
Leg fat-free mass (right)	1.3	7.1	16.5	4.1	2.7	2.7	2.8	3.0	1.1	-1.3	2.7	0.3	3.1	3.3	2.5
Arm fat percentage (left)	1.3	5.3	16.6	4.1	1.6	2.3	2.1	2.1	2.6	-0.6	2.0	-2.3	2.4	2.6	1.4
Average weekly red wine intake	1.2	1.8	3.5	-1.4	-1.6	-1.9	-1.6	-1.4	0.3	1.1	-1.2	-0.8	-1.4	-1.4	-1.6
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.5	0.0	-1.1	-0.5	-0.9	-1.1	-0.6	0.5	-1.2	-0.5	-1.1	-1.2	-1.0
Mood swings	1.4	2.6	6.9	2.6	1.6	1.7	1.2	1.5	1.3	-1.7	0.7	1.4	1.3	1.4	2.1
Loneliness, isolation	0.3	0.4	1.3	0.7	-0.1	0.9	-0.5	-0.4	-0.2	-1.1	-0.6	0.9	-0.6	-0.5	0.4
Long-standing illness, disability or infirmity	1.1	1.6	4.8	0.9	0.9	1.1	1.1	1.3	0.9	-2.2	0.6	-1.9	1.4	1.5	0.5
Ever had bowel cancer screening	0.5	0.6	4.5	-0.1	0.3	0.9	-0.2	0.5	-2.1	0.3	0.1	-1.0	0.4	0.5	-0.2
Diabetes diagnosed by doctor	1.3	2.2	5.0	1.9	1.1	2.2	1.5	1.2	1.3	-0.6	1.6	-1.6	1.4	1.5	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.7	0.7	0.5	0.6	1.2	1.0	0.1	-1.5	1.3	-2.2	1.4	1.5	0.2
Friendships satisfaction	1.2	1.5	8.8	1.2	0.1	-0.9	0.6	0.5	-1.8	-3.0	0.3	1.3	0.6	0.5	0.9
Qualifications: nursing, teaching	1.8	2.7	16.2	-0.2	-1.4	-2.6	1.6	0.9	-4.0	0.1	-1.1	1.1	1.2	0.6	0.4
Commuting to job workplace: Walk	1.6	1.7	3.6	-1.6	-0.8	0.1	-1.9	-1.7	-0.8	-0.0	-1.1	1.3	-1.8	-1.8	-0.7
Eye problems/disorders: Cataract	0.4	0.4	1.3	1.2	-1.1	-0.9	0.6	0.0	-0.4	-0.4	-0.9	-0.3	0.3	0.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	2.3	-0.3	-0.1	0.1	-0.7	-0.2	-0.0	-1.5	-0.1	-0.2	-0.2	-0.0	-0.1
Medication for cholesterol	0.9	1.4	5.2	-0.8	-0.4	-0.3	-1.5	-1.2	-2.3	1.3	-0.2	1.0	-1.4	-1.1	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.5	-1.8	-0.5	-1.7	-1.3	-1.1	-0.2	1.8	0.3	-2.0	-1.4	-1.1	-2.1
Back pain experienced in last month	0.8	1.2	4.3	1.2	1.5	2.1	-0.2	0.6	1.6	-0.4	1.3	0.1	0.3	0.6	0.6
Mineral and other dietary supplements	0.9	1.2	6.8	0.8	-0.5	-0.7	0.9	0.5	0.8	-1.8	0.1	-2.6	0.7	0.8	-0.7
Breast cancer (self-reported)	1.9	2.3	7.3	-0.6	-1.5	-0.9	-0.9	-1.1	-2.4	0.6	-2.7	2.4	-0.8	-1.4	0.3
Asthma (self-reported)	0.3	0.6	2.3	-1.3	0.6	-0.6	-0.0	0.2	0.4	1.5	1.3	-0.3	0.1	0.4	-0.2
Osteoporosis (self-reported)	0.7	0.8	1.9	-1.4	-0.6	-0.6	-1.0	-1.0	-0.4	0.2	-0.9	-0.8	-1.0	-1.1	-1.3
Osteoarthritis (self-reported)	0.7	0.9	3.2	0.9	0.4	0.2	1.0	0.8	0.8	0.4	1.6	-1.8	0.9	1.2	-0.2
Medication: Aspirin	0.3	0.3	1.6	-0.3	0.7	1.3	-0.3	0.0	0.8	-0.6	0.7	-0.4	-0.1	0.1	0.1
Medication: Gliclazide	0.8	0.9	3.8	2.0	0.6	0.4	1.1	0.9	1.0	-0.8	1.1	-0.1	0.8	0.8	0.6
Illnesses of father: None of the above (group 1)	0.9	1.2	6.5	0.5	0.6	2.5	0.8	0.5	-0.3	0.2	-0.8	1.4	0.9	0.6	1.5
Smoking status: Current	0.5	0.7	1.3	1.1	0.6	0.6	1.1	1.0	0.7	-0.9	0.8	0.0	1.1	1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	4.1	-2.0	-0.5	-1.8	1.0	0.7	-2.0	0.6	-0.9	1.1	0.9	0.4	0.6
Whole body water mass	0.8	4.7	12.0	3.5	2.2	2.5	2.0	2.3	1.0	-1.3	2.1	0.8	2.3	2.4	2.2
Leg predicted mass (right)	1.4	7.4	17.4	4.2	2.7	2.7	2.9	3.1	1.1	-1.4	2.7	0.4	3.2	3.3	2.6
Arm fat mass (left)	1.4	5.6	17.4	4.2	1.9	2.6	2.0	2.2	2.6	-0.8	2.1	-1.7	2.4	2.6	1.6
Number of self-reported non-cancer illnesses	0.9	1.6	5.0	1.1	0.9	0.8	1.2	1.4	1.2	-0.7	1.1	-2.2	1.5	1.7	0.5
Average weekly champagne plus white wine intake	4.7	6.5	12.8	1.5	2.4	1.7	3.4	3.3	-1.8	-0.7	1.4	2.2	3.5	3.1	3.6
Miserableness	2.0	3.5	6.8	2.6	1.6	1.3	2.2	2.3	-0.7	-1.8	1.1	0.7	2.2	2.2	2.4
Guilty feelings	0.6	0.9	1.9	0.9	-0.6	1.1	-1.0	-1.2	0.4	0.4	-1.2	0.8	-1.2	-1.4	-0.2
Wears glasses or contact lenses	1.0	1.2	2.3	0.8	1.2	0.8	1.4	1.4	0.3	-0.7	0.4	0.8	1.4	1.4	1.5
Ever taken oral contraceptive pill	0.5	0.5	2.2	-0.5	1.5	1.0	-0.0	0.5	-0.5	-0.1	1.1	0.8	0.1	0.3	0.6
Hearing aid user	2.0	2.3	4.1	1.4	1.5	1.5	2.0	1.7	0.6	-0.3	1.4	0.9	2.0	1.8	2.0
Mother’s age at death	0.8	1.0	3.6	0.1	-1.6	0.3	-1.1	-1.1	-0.8	0.6	-1.9	-0.8	-0.6	-0.8	-0.9
Financial situation satisfaction	0.3	0.4	0.8	0.9	0.1	-0.5	0.7	0.6	-0.2	-0.8	0.0	0.0	0.9	0.8	0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	0.4	0.1	0.7	0.0	-0.1	-0.3	-0.1	-0.1	0.6	-0.1	-0.1	0.5
Commuting to job workplace: Public transport	0.3	0.3	1.7	-0.9	0.0	-0.9	0.2	0.2	-1.3	-0.1	0.1	0.5	0.1	-0.1	0.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.5	0.6	-0.0	-0.7	1.1	0.7	-1.1	-0.0	-0.4	1.1	0.9	0.5	1.2
Medication: Blood pressure	0.9	1.6	4.3	1.0	0.9	0.4	1.5	1.4	2.1	-1.8	0.8	-1.0	1.4	1.3	0.8
Pain type(s) experienced in last month: Hip pain	2.5	3.1	8.5	2.9	1.5	1.0	2.2	2.2	0.9	-1.1	1.8	0.2	2.1	2.0	1.6
Supplements: Fish oil (including cod liver oil)	0.9	1.2	9.7	-0.0	0.4	0.8	-0.3	-0.1	-1.0	1.1	0.1	3.1	-0.3	-0.4	1.2
High cholesterol (Self-reported)	0.5	0.9	2.6	-0.5	-1.0	0.3	-1.2	-1.1	0.0	-0.9	-1.6	-0.9	-1.0	-1.1	-0.8
Medication: Bendroflumethiazide	0.3	0.4	2.7	-0.4	0.8	0.5	-0.2	0.3	1.6	0.5	0.8	-0.6	0.0	0.2	-0.1
Medication: Paracetamol	0.9	1.4	3.0	0.7	1.0	0.6	1.4	1.3	-0.3	-1.7	1.4	-1.4	1.4	1.5	0.3
Medication: Lisinopril	1.2	1.6	4.2	-0.1	-1.4	-0.3	-1.1	-1.1	1.7	2.1	-1.4	-1.5	-1.0	-1.0	-1.2
Medication: Atorvastatin	0.1	0.2	0.6	-0.6	-0.1	-0.0	-0.5	-0.4	-0.2	-0.8	-0.4	0.2	-0.4	-0.5	0.1
Illnesses of father: High blood pressure	0.9	1.1	3.4	-0.0	-1.4	-1.2	-0.6	-0.9	0.6	-0.5	-1.1	-1.9	-0.7	-0.8	-1.3
Alcohol drinker status: Never	2.4	2.8	5.9	2.1	1.1	0.9	2.4	2.2	-0.7	-1.8	0.6	1.0	2.2	1.9	1.9
Ever smoked	0.2	0.4	2.6	1.6	0.4	0.8	-0.2	-0.0	-0.5	-1.1	0.3	0.6	-0.1	-0.1	0.2
Basal metabolic rate	0.9	4.8	14.4	3.8	2.2	2.6	2.0	2.3	1.4	-1.1	2.0	0.3	2.3	2.4	2.1
Leg fat percentage (left)	1.0	3.7	13.0	3.6	1.2	2.7	1.0	1.2	3.2	-0.7	1.1	-1.7	1.3	1.5	1.1
Arm fat-free mass (left)	0.8	3.8	11.1	3.3	2.0	2.5	1.6	1.9	1.5	-1.2	1.8	0.8	1.8	1.9	2.0
Number of operations (self-reported)	4.2	6.2	13.3	2.9	2.2	0.9	3.6	3.2	-0.2	-0.9	2.3	1.1	3.3	3.2	2.9
Average weekly beer plus cider intake	0.4	0.5	2.7	1.0	0.9	1.6	0.2	0.5	0.4	-0.3	0.2	0.4	0.4	0.5	0.8
Irritability	0.4	0.7	6.1	0.8	0.1	-0.4	-0.0	0.0	-0.5	0.1	-0.7	2.5	-0.2	-0.4	0.9
Risk taking	0.8	1.1	3.9	-0.4	1.1	0.9	-1.2	-0.4	1.9	2.0	0.7	0.8	-0.7	-0.5	-0.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.4	0.0	0.7	0.5	0.5	0.6	-0.7	0.1	0.5	0.3	0.6	0.6	0.6
Fractured/broken bones in last 5 years	2.4	3.1	7.5	1.7	1.9	2.7	1.6	1.6	0.6	-2.6	1.1	-0.1	1.7	1.8	1.8
Age started oral contraceptive pill	0.2	0.3	1.7	-0.5	-0.3	-0.5	-0.2	-0.2	-1.3	-0.2	-0.3	0.6	-0.3	-0.3	0.0
Diastolic blood pressure, automated reading	1.1	3.3	5.9	-2.4	-1.4	-1.2	-2.4	-2.2	0.2	1.2	-2.2	0.9	-2.2	-2.4	-1.4
Ever depressed for a whole week	0.8	1.0	4.0	0.9	1.3	1.0	0.7	0.8	-0.2	-2.0	0.7	0.8	0.6	0.7	1.2
Unable to work because of sickness or disability	0.8	1.0	2.9	1.7	1.0	1.2	1.0	1.1	0.8	-0.8	0.7	-0.1	1.0	1.0	1.0
Commuting to job workplace: Cycle	0.3	0.3	1.8	-0.1	-0.3	-0.9	-0.1	0.0	0.7	1.3	0.2	-0.7	-0.0	0.1	-0.5
Myopia	0.9	1.3	2.6	-1.0	-0.4	0.5	-1.6	-1.3	-1.5	1.2	-0.5	-0.6	-1.6	-1.4	-1.2
Vascular/heart problems diagnosed by doctor	0.9	2.6	6.0	-1.4	-1.5	-0.5	-1.5	-1.8	-2.4	0.9	-2.1	1.8	-1.6	-1.9	-0.7
Cholesterol lowering medication	0.2	0.4	2.3	-0.0	-0.0	-0.3	0.1	0.1	1.5	-1.2	-0.1	-0.5	0.2	-0.0	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	1.1	0.4	0.3	0.8	0.8	1.1	-1.1	0.6	-0.4	0.9	0.8	0.7
Pain experienced in last month	0.9	1.5	6.6	-0.9	-1.6	-1.3	0.0	-0.7	-2.6	1.5	-1.6	0.1	-0.3	-0.6	-0.2
Supplements: Calcium	1.2	1.3	2.6	-1.6	-0.6	-0.4	-1.3	-1.2	-0.4	0.4	-1.2	1.6	-1.5	-1.6	-0.5
Basal cell carcinoma (self-reported)	0.9	1.0	6.1	-0.2	-1.1	-1.7	0.8	0.3	-2.5	0.1	-0.2	-0.6	0.7	0.4	-0.5
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.3	1.8	1.1	1.6	1.0	1.1	0.7	-0.4	1.1	0.8	1.2	1.1	1.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	0.1	0.3	-0.1	1.0	0.7	0.6	-0.3	0.6	-0.8	0.9	0.9	0.2
Heart disease (siblings)	1.2	1.5	2.7	1.0	1.1	-0.1	1.6	1.6	0.6	-1.6	1.4	-0.8	1.5	1.6	0.7
Alcohol drinker status: Previous	0.3	0.4	1.4	0.4	0.0	0.3	1.0	0.5	0.1	-1.2	0.5	-0.9	0.6	0.6	0.1
Pack years of smoking	1.3	1.9	6.3	1.4	1.8	2.5	0.8	1.2	1.5	-1.0	1.5	-0.7	0.9	1.2	0.8
Impedance of whole body	2.0	10.3	19.6	-2.5	-2.9	-2.0	-4.3	-4.2	0.4	2.6	-2.9	-1.2	-4.4	-4.4	-3.7
Leg fat mass (left)	1.0	3.9	15.6	4.0	1.3	2.7	1.3	1.5	2.5	-0.7	1.2	-1.5	1.7	1.8	1.3
Arm predicted mass (left)	0.8	4.0	10.7	3.3	2.0	2.3	1.8	2.1	1.4	-1.4	1.8	0.8	2.0	2.1	2.0