[Hub]/) : Traits : Impedance of leg (right) : ← →

chr14:103,161,201-104,892,153

Best TWAS P=9.88e-12 · Best GWAS P=5.42e-11 conditioned to 0.00235

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
34	YFS	Blood	KLC1	0.01	0.01	blup	389	0.01	1.0e-03	5.4	-6.8	9.9e-12	-0.61	0.11	0.70	TRUE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	MARK3	0.07	0.06	enet	7	0.08	1.0e-08	6.6	6.8	1.0e-11	0.95	0.00	1.00	FALSE
10	GTEx	Breast Mammary Tissue (Male)	MARK3	0.08	0.00	enet	9	-0.01	7.2e-01	6.0	6.7	2.0e-11	0.66	0.03	0.37	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	CKB	0.28	0.26	lasso	4	0.25	6.4e-14	6.5	6.6	4.6e-11	0.98	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	CKB	0.06	0.03	lasso	3	0.03	2.5e-06	6.6	6.6	4.9e-11	0.98	0.00	1.00	FALSE
17	GTEx	Lung	MARK3	0.06	0.02	lasso	3	0.01	6.6e-02	6.0	6.5	6.6e-11	0.77	0.04	0.91	FALSE
18	GTEx	Lung	CKB	0.07	0.01	lasso	2	0.01	3.4e-02	6.1	6.5	7.7e-11	0.71	0.05	0.85	FALSE
7	GTEx	Artery Tibial	TRMT61A	0.07	0.07	lasso	3	0.06	2.4e-05	5.8	6.5	9.4e-11	0.84	0.02	0.98	FALSE
2	GTEx	Adipose Visceral Omentum	KLC1	0.06	0.02	lasso	2	0.00	2.2e-01	6.1	-6.5	1.0e-10	-0.57	0.10	0.38	FALSE
28	GTEx	Skin Sun Exposed Lower leg	CKB	0.43	0.32	enet	16	0.34	5.9e-29	6.5	6.4	1.3e-10	0.96	0.00	1.00	FALSE
4	GTEx	Artery Aorta	KLC1	0.10	0.14	lasso	3	0.14	6.1e-08	6.0	-6.3	2.9e-10	-0.59	0.08	0.92	FALSE
22	GTEx	Pituitary	MARK3	0.21	0.27	enet	8	0.25	4.9e-07	6.0	6.3	3.1e-10	0.70	0.06	0.89	FALSE
13	GTEx	Cells Transformed fibroblasts	APOPT1	0.14	0.12	lasso	3	0.10	6.4e-08	5.9	6.3	3.2e-10	0.57	0.10	0.90	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	MARK3	0.10	0.03	blup	61	0.03	4.0e-04	6.5	6.2	4.6e-10	0.74	0.01	0.75	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	C14orf153	0.09	0.08	blup	38	0.09	6.2e-10	5.7	6.2	4.7e-10	0.64	0.01	0.99	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	MARK3	0.16	0.10	lasso	3	0.10	6.7e-06	6.1	6.2	6.5e-10	0.67	0.06	0.94	FALSE
16	GTEx	Esophagus Muscularis	KLC1	0.07	0.01	enet	10	0.02	2.6e-02	6.0	-6.1	1.2e-09	-0.58	0.07	0.66	FALSE
3	GTEx	Adrenal Gland	KLC1	0.15	0.03	lasso	3	0.06	4.6e-03	-4.7	-6.0	1.6e-09	-0.52	0.11	0.34	FALSE
8	GTEx	Breast Mammary Tissue	MARK3	0.12	0.11	lasso	2	0.08	3.9e-05	6.0	6.0	1.9e-09	0.69	0.07	0.89	FALSE
30	GTEx	Stomach	TRMT61A	0.12	0.11	lasso	5	0.08	1.2e-04	6.0	6.0	1.9e-09	0.69	0.07	0.88	FALSE
32	GTEx	Thyroid	MARK3	0.38	0.48	lasso	4	0.48	2.8e-41	6.0	6.0	2.1e-09	0.69	0.08	0.92	FALSE
44	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BAG5	0.08	0.09	lasso	2	0.08	3.7e-04	6.0	6.0	2.3e-09	0.69	0.00	0.96	FALSE
23	GTEx	Prostate	MARK3	0.18	0.22	enet	11	0.20	8.0e-06	6.0	6.0	2.6e-09	0.69	0.08	0.85	FALSE
29	GTEx	Stomach	MARK3	0.10	0.09	lasso	2	0.04	4.5e-03	6.0	6.0	2.7e-09	0.68	0.08	0.76	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MARK3	0.07	0.03	blup	64	0.06	5.5e-07	6.5	5.9	2.7e-09	0.85	0.01	0.99	FALSE
6	GTEx	Artery Tibial	KLC1	0.11	0.08	lasso	3	0.08	1.1e-06	6.1	-5.9	2.8e-09	-0.61	0.09	0.90	FALSE
31	GTEx	Testis	ZFYVE21	0.11	0.14	lasso	2	0.11	1.4e-05	5.9	-5.9	2.9e-09	-0.60	0.09	0.85	FALSE
38	The Cancer Genome Atlas	Glioblastoma Multiforme	C14orf153	0.14	0.01	blup	40	0.03	3.5e-02	5.7	5.9	2.9e-09	0.73	0.01	0.53	FALSE
21	GTEx	Muscle Skeletal	APOPT1	0.14	0.21	enet	10	0.22	6.7e-21	5.7	-5.9	3.3e-09	-0.62	0.30	0.70	FALSE
5	GTEx	Artery Tibial	ZFYVE21	0.11	0.09	lasso	1	0.08	8.0e-07	5.9	-5.9	3.4e-09	-0.60	0.10	0.90	FALSE
27	GTEx	Skin Sun Exposed Lower leg	MARK3	0.10	0.09	enet	13	0.08	7.5e-07	5.9	5.9	3.5e-09	0.76	0.08	0.92	FALSE
1	GTEx	Adipose Subcutaneous	MARK3	0.12	0.05	lasso	3	0.06	2.5e-05	5.9	5.9	4.2e-09	0.69	0.09	0.90	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	C14orf153	0.05	0.02	lasso	4	0.02	8.0e-05	5.7	5.8	5.3e-09	0.64	0.01	0.98	FALSE
15	GTEx	Esophagus Muscularis	ZFYVE21	0.11	0.06	lasso	5	0.05	5.7e-04	5.7	-5.8	5.9e-09	-0.61	0.14	0.77	FALSE
33	NTR	Blood	BAG5	0.02	0.00	lasso	5	0.01	6.3e-03	5.7	-5.8	8.6e-09	-0.64	0.19	0.60	FALSE
20	GTEx	Muscle Skeletal	KLC1	0.11	0.07	lasso	7	0.08	3.3e-08	6.0	-5.7	9.0e-09	-0.55	0.09	0.91	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	C14orf153	0.06	0.02	blup	38	0.04	2.4e-05	5.7	5.7	1.3e-08	0.54	0.02	0.92	FALSE
50	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C14orf153	0.20	0.07	blup	38	0.07	1.5e-03	-3.4	5.7	1.5e-08	0.61	0.02	0.42	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	C14orf153	0.07	0.05	lasso	4	0.04	1.5e-03	5.7	5.6	1.9e-08	0.61	0.01	0.84	FALSE
45	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C14orf153	0.11	0.11	lasso	3	0.10	1.1e-04	5.7	5.6	2.1e-08	0.60	0.01	0.95	FALSE
9	GTEx	Breast Mammary Tissue	KLC1	0.12	0.02	enet	26	0.07	2.9e-04	-4.7	-5.6	2.5e-08	-0.41	0.76	0.15	FALSE
19	GTEx	Muscle Skeletal	ZFYVE21	0.10	0.05	lasso	2	0.03	3.3e-04	5.9	-5.6	2.8e-08	-0.56	0.10	0.85	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRMT61A	0.02	0.00	blup	34	0.01	6.2e-02	-3.3	5.5	3.2e-08	0.62	0.02	0.39	FALSE
11	GTEx	Cells Transformed fibroblasts	ZFYVE21	0.10	0.03	lasso	4	0.11	1.1e-08	5.1	-5.4	5.5e-08	-0.56	0.23	0.60	FALSE
49	The Cancer Genome Atlas	Rectum Adenocarcinoma	BAG5	0.17	-0.01	blup	32	0.02	1.3e-01	-2.9	5.4	6.0e-08	0.62	0.01	0.46	FALSE
14	GTEx	Esophagus Mucosa	KLC1	0.17	0.09	lasso	5	0.12	1.6e-08	-4.7	-5.4	6.7e-08	-0.42	0.92	0.06	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CKB	0.03	0.00	blup	34	0.02	1.4e-03	-2.8	5.4	6.9e-08	0.69	0.01	0.81	FALSE
12	GTEx	Cells Transformed fibroblasts	KLC1	0.16	0.11	enet	17	0.10	3.1e-08	-4.2	-5.3	9.7e-08	-0.43	0.94	0.05	FALSE
39	The Cancer Genome Atlas	Glioblastoma Multiforme	MARK3	0.12	0.05	blup	64	0.07	3.3e-03	6.1	5.2	1.8e-07	0.58	0.02	0.27	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	TRMT61A	0.03	0.01	blup	32	0.01	1.4e-02	5.8	5.2	2.3e-07	0.50	0.01	0.19	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	XRCC3	0.14	0.03	lasso	14	0.03	1.3e-02	-4.7	-5.2	2.5e-07	-0.37	0.61	0.24	FALSE