Best TWAS P=1.91e-11 · Best GWAS P=1.8e-09 conditioned to 0.0962
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 7 | GTEx | Nerve Tibial | EHD4 | 0.20 | 0.04 | lasso | 7 | 0.08 | 2.4e-06 | 4.0 | -6.7 | 1.9e-11 | -0.72 | 0.03 | 0.97 | TRUE |
| 1 | GTEx | Artery Coronary | CATSPER2 | 0.81 | 0.14 | lasso | 12 | 0.03 | 3.0e-02 | 4.9 | -5.7 | 1.5e-08 | 0.00 | 0.12 | 0.43 | TRUE |
| 11 | GTEx | Thyroid | PLA2G4B | 0.14 | 0.09 | enet | 11 | 0.08 | 1.6e-06 | 5.2 | 6.5 | 9.9e-11 | 0.47 | 0.24 | 0.76 | FALSE |
| 2 | GTEx | Artery Tibial | EHD4 | 0.14 | 0.03 | enet | 21 | 0.06 | 1.0e-05 | 4.4 | -6.1 | 8.8e-10 | -0.48 | 0.35 | 0.57 | FALSE |
| 4 | GTEx | Brain Cerebellum | MAPKBP1 | 0.23 | 0.09 | lasso | 8 | 0.12 | 2.2e-04 | 5.1 | -6.0 | 1.9e-09 | -0.41 | 0.20 | 0.53 | FALSE |
| 5 | GTEx | Brain Cerebellum | RP11-23P13.4 | 0.19 | 0.05 | enet | 13 | 0.10 | 7.6e-04 | 5.1 | -5.9 | 3.9e-09 | -0.39 | 0.14 | 0.31 | FALSE |
| 10 | GTEx | Thyroid | RP11-23P13.6 | 0.07 | 0.00 | lasso | 5 | 0.01 | 9.6e-02 | 4.0 | -5.7 | 9.6e-09 | -0.05 | 0.07 | 0.35 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-23P13.7 | 0.11 | 0.07 | lasso | 7 | 0.06 | 2.3e-04 | -4.6 | 5.4 | 8.4e-08 | 0.23 | 0.35 | 0.30 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | PLA2G4B | 0.17 | 0.18 | lasso | 5 | 0.18 | 2.9e-10 | 5.1 | 5.2 | 2.0e-07 | 0.15 | 0.25 | 0.75 | FALSE |
| 3 | GTEx | Artery Tibial | LCMT2 | 0.25 | 0.03 | enet | 33 | 0.08 | 6.5e-07 | 3.9 | -5.1 | 2.7e-07 | -0.01 | 0.10 | 0.74 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Male) | ADAL | 0.16 | 0.12 | lasso | 5 | 0.13 | 6.9e-04 | 4.9 | -5.1 | 3.1e-07 | -0.01 | 0.05 | 0.64 | FALSE |