Hub : Genes

EHD4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2530	0.0660	1.9e-04	0.003	NA	0.071	NA	0.042	1.9e-01	NA	2.0e-06	NA	2.2e-04
2	GTEx	Artery Tibial	0.1355	0.0426	8.0e-05	0.034	NA	0.063	NA	0.047	1.1e-03	NA	1.0e-05	NA	1.4e-04
3	GTEx	Brain Cerebellar Hemisphere	0.2470	0.0990	3.3e-03	0.168	NA	0.106	NA	0.132	4.4e-05	NA	1.1e-03	NA	2.9e-04
4	GTEx	Brain Cerebellum	0.3650	0.1040	6.7e-05	0.314	NA	0.225	NA	0.286	5.5e-10	NA	2.9e-07	NA	4.3e-09
5	GTEx	Heart Atrial Appendage	0.2920	0.0770	1.5e-04	0.144	NA	0.046	NA	0.099	5.3e-07	NA	3.8e-03	NA	3.5e-05
6	GTEx	Heart Left Ventricle	0.2026	0.0723	1.7e-03	0.140	NA	0.081	NA	0.118	6.4e-08	NA	4.3e-05	NA	7.8e-07
7	GTEx	Nerve Tibial	0.2004	0.0613	4.7e-05	0.043	NA	0.063	NA	0.081	5.3e-04	NA	3.0e-05	NA	2.4e-06
8	METSIM	Adipose	0.0965	0.0412	1.9e-03	0.047	0.003	0.025	0.030	0.032	1.4e-07	1.0e-01	9.2e-05	2.4e-05	1.0e-05
9	YFS	Blood	0.4818	0.0398	0.0e+00	0.346	0.403	0.436	0.427	0.434	7.9e-119	8.5e-144	2.1e-159	6.0e-155	2.6e-158
10	TCGA	Breast Invasive Carcinoma	0.0370	0.0139	4.4e-04	0.020	0.017	0.008	NA	0.013	5.4e-05	1.4e-04	7.1e-03	NA	8.6e-04
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0508	0.0223	2.0e-03	0.022	0.037	0.034	NA	0.034	1.5e-03	4.2e-05	8.8e-05	NA	8.6e-05
12	TCGA	Prostate Adenocarcinoma	0.1744	0.0462	8.4e-08	0.088	0.092	0.079	NA	0.079	1.7e-09	6.8e-10	1.1e-08	NA	1.1e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.9	1.4	3.6	-0.2	1.4	0.1	0.3	0.1	1.2	1.7	-1.0	-1.9	-1.9	0.2	-1.3
Bipolar Disorder or Schizophrenia	0.4	1.0	3.3	1.5	1.4	0.1	0.0	0.1	0.1	1.8	1.3	-1.4	-0.4	0.7	0.0
Depressed Affect (Nagel 2018)	0.7	1.4	5.3	1.4	0.1	1.0	1.5	0.8	0.8	0.3	0.7	0.9	2.3	1.7	0.9
Depression (Nagel 2018)	0.8	1.2	4.1	2.0	-1.1	-0.4	-0.6	-1.2	-0.6	-0.7	1.6	0.7	1.7	0.6	0.6
Intelligence (Savage-Jansen 2018)	0.8	2.6	7.3	2.7	1.9	-0.1	-0.2	-0.9	-1.6	2.3	0.8	-2.2	-1.2	-1.7	1.0
Neuroticism (Nagel 2018)	0.5	1.1	4.3	0.8	-0.2	1.1	0.7	0.1	-0.1	0.4	1.5	0.0	2.1	1.6	1.1
Schizophrenia (2018)	0.6	1.3	6.1	2.1	0.7	0.0	-0.2	0.1	-0.9	0.9	2.5	-0.3	1.1	0.8	1.2
Schizophrenia vs Biploar Disorder	0.6	0.8	2.0	0.5	0.1	0.8	0.4	-0.3	-1.4	-0.9	1.4	0.2	1.4	-0.3	1.3
Worry (Nagel 2018)	0.8	1.7	5.5	0.6	1.1	2.4	1.7	0.2	0.4	1.4	1.0	-0.8	1.6	1.6	1.4
Alzheimer’s Disease (in mother)	0.2	0.3	0.8	-0.4	-0.1	0.9	0.1	-0.5	-0.5	-0.5	-0.7	-0.2	-0.7	-0.9	-0.1
Alzheimer’s Disease (in father)	0.9	1.0	4.8	0.2	0.7	1.8	2.2	-0.1	-0.4	0.2	0.3	-1.6	-0.0	0.4	-0.4
Alzheimer’s Disease (including proxy)	0.3	0.4	1.5	-0.4	0.5	1.2	0.9	-0.2	-0.4	-0.1	-0.3	-0.9	-0.7	-0.9	-0.2
Crohns Disease (2017)	0.4	0.9	4.6	0.1	0.9	-0.0	0.8	0.9	1.1	0.9	-1.0	-0.2	-0.6	0.1	-2.1
Irritable Bowel Disease (IBD)	0.6	1.4	3.4	0.4	1.1	-0.0	1.0	1.6	1.6	1.8	-0.2	-0.5	0.3	1.8	-1.5
Ulcerative Colitis (UC)	0.7	1.3	7.6	-0.3	0.1	0.1	0.7	1.3	1.4	1.2	0.3	-0.1	1.3	2.8	-0.5
Major Depression (MDD)	0.6	0.7	3.0	-1.1	-1.7	0.2	-1.3	0.4	0.2	-1.2	-0.9	-0.2	-0.2	0.6	0.3
Reaction Time	1.8	3.3	15.7	-1.1	-4.0	-0.7	-1.5	0.9	1.0	-3.1	-0.7	1.9	1.0	1.8	0.8
Verbal and Numeric Reasoning (VNR)	0.9	2.2	10.2	3.2	1.6	-0.7	-0.7	0.5	-0.1	2.6	0.6	-1.9	-0.9	-0.9	0.6
Breast Cancer	1.6	3.8	11.3	0.7	2.4	3.4	2.0	1.4	1.4	1.8	1.1	-2.0	2.0	1.4	2.5
Ovarian Cancer	0.8	1.1	3.9	0.6	-1.8	-0.3	-0.8	0.2	-0.1	-1.8	-0.6	2.0	0.8	0.3	0.8
Prostate Cancer	0.7	1.0	2.8	-1.4	-1.2	-1.1	-0.7	0.6	0.6	-0.4	-1.7	1.7	-0.8	0.2	0.4
Age at First Birth	0.5	0.7	1.6	0.9	0.1	-0.6	0.2	-0.4	-1.3	1.2	0.4	-0.5	-1.1	-0.7	-1.3
Bipolar Disorder (2011)	0.1	0.1	0.5	-0.2	0.4	0.2	-0.3	-0.4	0.7	0.5	0.0	-0.5	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	3.0	0.9	1.3	0.5	0.7	-0.3	0.1	1.0	0.7	-1.7	0.1	-0.3	0.8
Coronary Artery Disease (CAD)	1.3	1.5	5.3	-0.3	-1.4	-0.9	-1.2	-1.4	-2.3	-1.7	0.4	-0.1	-0.9	-1.2	-1.2
Crohns Disease (2012)	1.1	1.8	4.1	0.3	1.9	1.4	1.8	0.8	0.8	2.0	-0.8	-1.9	-1.1	-0.2	-1.5
Mean Putamen Volume	0.3	0.3	1.3	0.7	0.3	-0.3	0.1	0.1	-0.1	1.1	0.1	-1.1	-0.6	0.1	-0.2
Fasting Glucose	0.5	0.6	1.4	0.5	-1.2	-1.0	-1.1	-0.9	-0.8	-0.8	0.3	0.6	-0.2	-0.5	0.8
HbA1C	0.6	0.7	2.7	-0.1	-0.6	-1.1	-0.6	0.2	-0.8	0.1	0.5	0.6	-1.6	-1.5	0.0
HDL Cholesterol	1.3	2.1	6.1	0.5	2.5	1.0	2.0	1.9	1.3	2.4	-0.4	-1.1	-0.1	1.0	-0.7
LDL Cholesterol	0.2	0.3	1.4	0.9	-0.4	-0.2	-0.1	0.1	-0.1	0.2	1.2	0.7	0.4	-0.0	0.6
Lupus	0.7	1.1	3.5	-1.5	-0.3	-0.5	-0.5	-1.9	-1.6	-0.6	1.5	-0.3	-1.0	-0.9	0.1
Neuroticism (2016)	1.1	1.7	5.7	-0.1	-1.9	-0.8	-2.4	0.5	-0.1	-1.1	0.6	1.7	1.3	0.7	1.8
Primary Biliary Cirrhosis	0.1	0.2	0.8	-0.1	-0.3	-0.6	-0.3	0.7	0.5	-0.2	-0.9	0.2	-0.3	0.2	-0.0
Rheumatoid Arthritis	0.7	0.9	3.1	-1.5	-0.3	0.5	0.4	0.6	0.3	-0.8	-1.2	-1.4	-0.4	0.7	-1.8
Schizophrenia (2014)	0.6	1.3	6.1	2.5	0.9	-0.3	-0.2	-0.8	-1.3	1.1	1.9	-1.1	0.0	0.2	-0.3
Triglycerides	2.3	3.8	13.6	0.2	-3.7	-2.2	-3.0	-1.0	-1.2	-2.7	0.5	2.2	-0.3	-0.6	1.4
Type 2 Diabetes (T2D) (2012)	1.0	1.2	4.0	-2.0	-1.0	0.1	-0.3	-1.6	-1.6	-1.1	-0.1	1.0	-0.2	-1.2	-0.4
Ulcerative Colitis	0.8	1.1	4.1	0.0	0.9	0.8	1.0	1.0	0.9	1.3	0.5	-1.5	0.8	2.0	-0.7
Blood Eosinophil Count	2.4	18.4	36.4	-1.4	-4.4	-6.0	-5.1	-3.0	-3.9	-5.1	-3.3	3.1	-4.7	-5.2	-4.2
Blood Platelet Count	2.1	24.9	75.8	-2.6	-4.7	-0.3	-0.9	-1.9	-2.7	-5.9	-8.7	-1.0	-8.1	-5.4	-7.1
Blood Red Count	1.0	9.3	29.7	-3.8	-4.9	-2.9	-3.3	-0.9	-1.3	-5.5	-2.1	2.8	-1.6	-2.4	-1.1
Blood White Count	6.7	50.0	182.2	-8.3	-8.0	-2.9	-2.1	0.4	-0.8	-9.2	-13.5	1.6	-8.9	-4.6	-9.2
Heel T-Score	1.1	8.6	33.5	1.3	-1.0	0.7	1.0	-4.5	-5.4	-2.5	2.5	-0.2	-2.1	-5.8	-0.6
BMI	0.3	2.0	7.0	2.6	2.6	-0.2	0.3	0.9	0.9	2.0	0.5	-0.9	1.3	0.8	0.9
Height	0.3	5.0	16.8	-2.5	-0.8	-4.1	-3.2	0.1	-0.1	-0.8	-0.7	3.3	-2.7	-2.4	-0.8
Waist Hip Ratio (WHR)	3.1	13.9	45.3	-3.5	-6.7	-3.3	-4.7	-2.0	-2.6	-6.7	-0.8	3.3	-1.7	-2.3	-1.2
Systolic Blood Pressure	3.0	15.0	32.9	-2.7	-5.7	-3.3	-4.9	-3.8	-5.2	-5.6	-0.3	0.9	-3.9	-4.0	-1.0
Smoking Status	0.9	2.2	6.4	-0.8	-2.5	-1.6	-1.5	-1.2	-1.4	-2.3	-0.7	1.5	-1.1	-1.3	-0.7
Allergy or Eczema	0.7	2.0	12.3	3.5	0.6	-2.0	-1.1	0.5	0.4	0.6	0.4	1.8	0.6	0.2	0.9
Cardiovascular Disease	2.4	7.9	22.4	-1.6	-4.7	-3.4	-4.7	-1.3	-2.1	-4.7	-1.4	1.1	-1.1	-1.1	-1.1
Hypothyroidism (self reported)	2.0	4.6	12.2	-0.7	-3.2	-3.2	-3.5	-0.7	-1.9	-2.3	-0.5	2.4	-1.9	-1.6	-0.9
Respiratory disease	0.8	1.8	6.6	2.6	-0.4	-1.9	-1.1	0.9	0.2	1.1	0.8	1.3	1.0	1.3	1.5
Type 2 Diabetes (T2D) (2018)	1.7	3.2	11.6	-1.0	-3.4	-1.9	-2.6	-1.4	-1.6	-2.7	0.4	1.7	-0.4	-0.9	-0.2
Lung FEV1/FVC ratio	3.6	18.5	71.9	-3.2	-5.8	-6.2	-8.5	-2.8	-2.5	-5.8	-0.5	3.5	-1.0	-2.2	0.3
Lung FVC	0.9	4.6	22.1	0.5	2.7	2.7	2.7	-1.9	-1.1	0.9	1.4	-4.7	0.5	0.6	-1.7
Neuroticism	1.2	2.9	5.2	1.9	1.5	2.1	1.7	1.3	1.3	2.2	0.9	-0.9	2.1	2.3	1.5
Chronotype (morning person)	0.8	1.9	5.9	-0.8	1.7	2.4	2.0	-0.2	0.7	0.9	0.3	-1.8	1.3	1.4	1.0
Hair Pigment	0.0	1.3	3.8	-1.3	-0.6	0.7	0.2	-1.9	-1.8	-0.7	1.6	-0.6	1.0	0.1	1.1
Tanning	0.1	0.6	1.7	-1.3	-0.4	0.1	1.0	0.1	0.6	-0.8	-1.2	0.3	0.5	0.5	-1.2
Hand grip strength (left)	0.1	0.3	1.0	-1.0	0.8	0.5	0.8	-0.4	0.1	-0.2	-0.2	-0.1	0.7	0.2	-0.2
Number of treatments/medications taken	3.3	6.0	17.9	0.0	-3.6	-3.8	-4.2	-0.3	-1.2	-2.7	-1.1	3.3	-1.3	-1.5	-1.4
Average weekly spirits intake	0.5	0.6	1.7	-1.0	0.1	0.5	1.1	-1.3	-0.9	-1.0	1.0	-0.1	0.2	-0.3	-0.5
Sensitivity / hurt feelings	0.4	0.7	3.6	-0.3	-0.5	1.2	-0.1	-0.8	-0.3	-0.3	0.6	-1.9	0.5	0.9	0.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.4	0.7	-1.4	-0.6	-1.2	-0.9	-0.5	-1.1	1.1	0.7	1.5	0.5	1.1
Hearing difficulty/problems: Yes	0.8	1.2	5.3	-0.4	1.3	0.3	0.8	-1.1	-1.4	0.7	0.3	-1.1	-0.5	-0.9	-2.3
Relative age of first facial hair	0.5	1.0	4.1	-0.1	-2.0	-1.1	-0.6	-0.3	-0.8	-1.7	-0.8	1.4	-0.4	-0.3	-0.5
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.9	-0.4	-1.4	-1.3	-1.7	-1.8	-1.9	-0.9	-0.3	-0.5	-1.4	-0.8	-2.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.6	1.0	-0.1	-0.2	-1.0	1.3	0.9	0.7	-0.4	-0.3	0.1	0.7	1.1
Ever had hysterectomy (womb removed)	1.4	1.6	3.1	-0.3	-1.7	0.0	-0.5	1.5	1.8	-1.0	-1.7	1.1	1.4	1.3	1.3
Systolic blood pressure, automated reading	2.3	6.6	18.5	-0.8	-3.2	-2.2	-3.1	-2.8	-4.3	-3.4	0.6	1.5	-1.8	-3.1	0.9
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	7.2	0.0	-1.5	-0.4	-0.3	2.7	2.3	-0.9	-2.0	2.1	-0.3	1.2	-0.0
Angina	1.9	2.5	6.4	1.9	-1.6	0.4	0.3	-0.4	-0.0	-2.0	-1.5	1.0	-2.5	-2.2	-2.2
Medication for hormone replacement therapy	1.0	1.1	2.6	1.5	0.9	1.0	1.3	1.6	1.0	1.1	-1.0	-0.7	-0.4	0.6	-0.6
Vitamin and mineral supplements	1.0	1.4	3.7	-0.4	0.4	1.1	1.0	-1.8	-1.7	-0.8	0.4	-0.6	-1.4	-1.9	-0.9
Supplements: Zinc	1.3	1.5	5.8	-0.3	-1.1	-0.7	-1.6	1.6	2.4	-0.3	-1.2	0.0	0.1	1.8	-0.3
Medication: Co-codamol	0.9	1.0	3.4	-1.7	-1.4	-0.0	-0.4	0.7	0.0	-1.4	-1.8	0.2	0.8	0.7	-0.5
Medication: Metformin	2.9	4.1	14.3	-0.1	-3.8	-1.9	-2.7	-1.7	-2.3	-3.4	0.5	1.3	-0.4	-1.4	-0.6
Diabetes (father)	3.5	4.3	14.3	-1.5	-1.3	-3.8	-3.5	-2.5	-2.6	-1.0	1.4	0.9	-0.7	-1.6	-1.4
Diabetes (mother)	2.4	3.0	6.7	-1.1	-2.5	-1.1	-2.3	-1.9	-2.6	-2.6	1.7	-0.0	-0.3	-1.4	0.5
Severe depression (siblings)	1.6	1.7	4.2	-2.1	1.5	1.8	2.0	0.1	1.4	1.0	-0.5	-0.9	1.0	1.4	0.5
Pack years adult smoking proportion	0.9	1.4	5.2	0.6	-0.2	-0.3	-0.6	2.3	2.1	0.3	-0.8	0.7	0.9	1.2	1.7
Impedance of leg (right)	3.0	14.5	45.0	-4.5	-6.1	-2.3	-3.0	-1.2	-2.5	-6.7	-3.1	3.8	-2.6	-3.4	-2.5
Leg fat-free mass (left)	1.1	5.7	18.2	2.6	4.2	1.0	1.5	1.2	2.0	4.3	1.5	-2.2	1.4	2.2	1.9
Trunk fat percentage	0.1	0.4	1.7	0.5	-0.2	-1.3	-0.9	0.1	-0.5	-0.9	-0.5	-0.1	-0.5	-0.4	-0.3
Hand grip strength (right)	0.1	0.2	1.3	-1.2	-0.2	-0.3	0.1	-0.2	0.4	-0.3	-0.0	0.5	0.4	0.0	0.1
Townsend deprivation index at recruitment	0.6	0.8	1.6	-0.1	-0.9	1.2	-0.0	-1.3	-1.2	-1.2	-0.3	-1.2	-0.3	-0.5	-0.8
Current tobacco smoking	0.4	0.6	2.1	-0.7	-1.4	-0.9	-0.9	-0.1	0.0	-1.3	-0.5	0.8	-0.2	-0.2	0.3
Average weekly fortified wine intake	0.4	0.4	1.3	1.1	0.0	-0.9	-0.3	0.4	-0.0	0.0	0.8	1.0	0.7	0.2	0.7
Maternal smoking around birth	0.3	0.5	2.0	0.1	-1.2	-0.1	0.4	0.1	-0.4	-1.4	0.2	0.9	0.6	0.6	-0.8
Fed-up feelings	0.3	0.6	2.1	0.7	-0.5	1.4	0.9	1.2	0.5	-0.1	-0.7	-0.5	0.3	0.7	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.3	1.5	-1.1	-0.0	-0.6	-1.0	-0.6	-0.5	1.3	0.5	1.3	0.6	1.2
Relative age voice broke	1.5	2.4	5.7	0.3	-2.4	-1.4	-1.9	-0.0	-0.9	-1.8	-0.9	0.2	-2.2	-1.3	-2.2
Taking other prescription medications	0.8	1.2	5.3	0.8	-1.2	-1.9	-2.3	-0.1	-0.9	-0.4	-0.4	1.2	-0.5	-0.5	0.2
Age when periods started (menarche)	0.9	2.1	8.5	-2.9	-2.0	-0.3	-0.6	-0.3	0.2	-2.0	-2.2	1.2	-1.0	-0.1	-0.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.9	0.9	-0.7	0.1	-0.9	1.4	1.0	-0.1	0.8	0.0	1.0	1.1	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	6.3	1.0	-0.1	0.1	0.2	-1.5	-2.3	-1.0	0.3	-1.5	-1.6	-2.5	-1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.9	-0.1	-1.1	0.1	-1.1	-0.2	-0.7	-0.4	0.7	0.6	0.9	1.4	1.1
Qualifications: CSEs or equivalent	1.3	1.7	5.9	-1.1	-0.3	1.6	0.9	-0.3	0.4	-0.1	1.0	-0.3	2.2	2.4	1.9
Serious illness, injury or assault to yourself	1.4	1.7	4.3	-0.8	-1.6	-1.5	-1.9	1.1	1.1	-0.6	-2.1	2.0	-0.2	0.1	-0.5
High blood pressure	2.4	6.6	24.0	-0.5	-4.9	-2.5	-4.0	0.1	-1.2	-4.3	-2.0	0.6	-2.3	-0.7	-1.6
Hayfever, allergic rhinitis or eczema	1.4	2.9	8.3	2.9	0.2	-2.5	-1.5	1.1	1.0	0.6	1.3	2.3	1.9	1.0	2.0
Multivitamins +/- minerals	1.5	1.9	3.2	1.7	-0.5	-1.8	-1.3	1.8	1.6	0.9	-0.1	1.6	1.1	1.4	1.5
Stomach or abdominal pain in last month	0.9	1.1	3.4	-0.4	0.3	0.6	-0.2	1.8	1.2	0.6	0.1	-1.0	1.3	1.7	1.5
Supplements: Glucosamine	0.3	0.4	2.2	-0.2	0.5	1.5	1.1	-0.2	-0.4	-0.3	-0.6	-0.7	0.3	0.4	0.0
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	4.6	1.6	1.5	1.0	0.4	1.0	-0.3	2.1	0.9	-1.8	0.7	0.4	2.1
Medication: Atenolol	0.6	0.7	2.4	0.5	-0.5	-0.0	-0.6	-0.0	-0.2	-1.2	-1.5	-0.1	-1.0	-1.1	-1.3
Medication: Levothyroxine sodium	1.6	2.8	7.0	-0.5	-2.5	-2.6	-2.6	-0.6	-1.6	-1.8	0.9	2.5	0.2	-0.4	-0.1
Sitting height	0.4	2.8	11.1	0.1	3.3	0.4	0.5	0.4	0.1	2.6	2.7	-0.9	1.6	0.4	2.0
Chronic bronchitis/emphysema (father)	0.7	0.8	3.3	0.9	-0.6	1.8	1.1	1.0	0.8	-0.4	-0.6	-0.6	0.6	0.9	0.8
High blood pressure (mother)	1.5	2.1	5.3	-2.3	-2.1	-1.2	-1.7	1.4	1.4	-1.6	-1.7	0.8	-0.3	0.7	-1.0
Body mass index (BMI)	0.3	1.1	5.0	2.2	1.7	-0.5	-0.0	0.2	0.1	1.5	0.8	-1.1	0.7	0.8	0.6
Impedance of leg (left)	2.5	12.0	36.4	-4.6	-5.3	-2.0	-2.4	-1.0	-2.3	-6.0	-2.8	3.6	-2.2	-3.1	-2.6
Leg predicted mass (left)	1.1	5.9	18.8	2.6	4.2	1.0	1.5	1.2	2.0	4.3	1.6	-2.2	1.4	2.2	2.0
Trunk fat mass	0.1	0.3	1.2	1.1	0.8	-1.0	-0.6	0.5	0.1	0.2	-0.1	-0.5	-0.1	0.1	0.2
Waist circumference	0.3	1.0	3.6	0.7	-0.8	-1.6	-1.9	-0.7	-1.3	-0.9	0.5	-0.3	-0.9	-1.0	0.1
Number of incorrect matches in round	0.4	0.6	1.3	-0.7	-0.7	-0.8	-0.7	-1.0	-0.5	-0.6	1.2	0.2	1.1	0.8	0.1
Past tobacco smoking	0.8	1.5	4.9	1.1	1.4	-0.1	-0.0	1.0	1.1	1.0	1.7	0.7	1.7	0.7	2.2
Alcohol usually taken with meals	1.4	2.3	9.6	1.6	3.1	0.0	1.0	0.5	0.2	3.1	0.5	-1.1	-0.6	-1.4	-0.3
Nervous feelings	0.7	1.3	4.3	0.5	1.2	1.8	1.1	1.1	1.0	2.1	0.1	-1.1	-0.2	1.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	3.4	0.7	-1.3	-0.0	-0.3	-0.9	-0.7	-0.4	1.2	0.6	1.4	1.0	1.8
Hearing difficulty/problems with background noise	1.3	2.0	6.7	-1.0	1.7	0.6	0.8	-1.1	-1.1	1.3	0.0	-2.6	-1.4	-0.4	-2.6
Hair/balding pattern: Pattern 2	0.7	0.9	3.0	0.4	0.3	1.0	1.3	1.5	1.0	1.7	0.4	0.1	0.6	0.9	0.8
Had menopause	1.4	1.8	6.6	1.5	-0.2	0.3	-0.3	-1.8	-2.6	-0.4	1.9	-0.1	-0.5	-2.1	0.8
Had other major operations	2.0	2.4	6.5	1.3	1.9	0.9	1.4	-1.1	-1.7	0.6	-0.3	-1.8	-1.6	-2.6	-2.0
Forced vital capacity (FVC)	0.6	2.3	5.1	-1.7	2.0	1.9	1.8	-2.3	-1.2	0.8	0.9	-2.2	0.1	0.2	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	5.9	1.3	0.7	0.7	1.2	-1.6	-2.4	-0.5	1.0	-1.3	-1.1	-2.4	-0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.3	1.2	0.4	0.6	0.3	-0.7	-0.0	0.6	1.4	-0.6	1.8	1.5	0.6
Qualifications: None of the above	0.2	0.4	1.3	-0.6	-0.3	-0.1	0.4	-0.1	-0.7	-1.1	-0.7	-0.3	-1.0	-0.8	-0.1
Financial difficulties in last 2 years	1.4	1.8	6.5	-1.1	-2.6	-1.2	-1.1	-0.8	-1.3	-2.5	0.0	0.9	-0.6	-1.2	-0.6
Mouth/teeth dental problems	0.2	0.2	1.8	-0.7	-0.1	-0.2	-0.5	-1.3	-0.4	-0.3	-0.0	-0.3	0.0	-0.1	0.3
Heart attack	1.9	2.5	6.3	-0.5	-1.3	-0.5	-0.0	-0.8	-1.9	-1.9	-1.8	0.7	-2.3	-2.5	-2.1
Allergy	2.0	4.6	15.2	-3.9	-0.1	3.1	2.1	-0.1	0.4	-0.7	-2.9	-2.5	-2.1	-0.3	-2.4
Pain all over the body in last month	0.8	0.9	2.2	-0.5	-1.5	-0.2	-0.9	0.2	0.4	-1.4	-0.9	1.3	1.1	1.0	0.4
Diabetes (self-reported)	1.4	2.1	8.2	0.1	-2.9	-1.5	-2.7	-0.5	-1.3	-2.0	0.2	1.1	-0.5	-0.6	0.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	4.1	1.7	-0.4	-0.4	-0.2	-0.6	-0.9	-0.8	2.0	0.7	0.9	-0.1	0.4
Medication: Ramipril	1.0	1.3	4.9	-1.2	-1.9	0.9	0.1	0.4	0.3	-2.2	-1.8	-0.2	-0.5	0.4	-1.1
Medication: Simvastatin	1.1	1.6	7.9	0.2	-2.8	-0.8	-2.0	-0.5	-0.8	-2.1	-0.5	0.3	-0.8	-0.6	-0.3
Fluid intelligence score	1.0	2.1	8.8	2.6	1.5	-0.8	-0.8	1.3	0.7	3.0	1.2	-1.3	-0.3	-0.0	0.8
Illnesses of siblings	0.5	0.7	2.0	-0.1	0.5	1.2	0.8	-1.4	-1.3	0.2	1.1	-0.2	0.5	-0.7	0.7
Neuroticism score	1.1	2.3	6.8	1.2	1.2	2.6	1.8	1.2	1.3	1.9	0.2	-1.6	0.9	1.8	1.1
Weight	0.3	1.5	6.5	1.7	2.5	-0.4	0.1	0.5	0.4	2.2	0.8	-1.2	0.3	0.6	0.6
Impedance of arm (right)	1.4	6.7	19.7	-3.0	-3.7	-2.1	-2.0	-1.0	-2.4	-4.4	-1.0	2.4	-2.2	-2.8	-1.8
Arm fat percentage (right)	0.1	0.4	1.7	1.1	0.4	-1.3	-0.7	0.1	-0.7	-0.2	0.4	-0.6	0.3	0.0	0.1
Trunk fat-free mass	0.6	3.5	13.7	1.9	3.6	0.5	0.8	0.4	1.0	3.7	1.5	-1.6	1.1	1.2	1.4
Hip circumference	0.4	1.6	6.9	1.5	2.6	-0.2	0.6	0.5	-0.0	2.3	0.9	-1.6	0.1	0.3	0.5
Time employed in main current job	0.2	0.2	0.8	0.1	-0.7	0.2	-0.4	0.0	0.1	-0.3	0.5	0.1	0.9	0.7	0.6
Alcohol intake versus 10 years previously	0.4	0.7	2.0	-1.4	-0.9	-0.7	-1.1	-0.4	-0.7	-0.5	0.2	-1.0	-0.7	0.0	-1.0
Father’s age at death	2.9	3.9	10.6	0.8	3.2	3.1	3.3	0.2	0.8	2.5	1.2	-0.8	1.1	0.6	2.3
Worrier / anxious feelings	0.7	1.3	3.5	1.8	0.3	1.9	1.0	0.6	0.6	0.8	0.8	-1.5	0.9	1.5	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	2.7	0.6	0.6	0.0	0.1	-1.1	-1.6	0.4	1.6	-0.5	1.6	-0.1	1.1
Falls in the last year	2.8	3.8	5.9	-1.6	-2.0	-2.4	-2.4	-2.0	-2.4	-2.4	-0.7	1.1	-1.2	-2.3	-2.0
Hair/balding pattern: Pattern 3	1.4	2.1	7.0	0.0	-1.1	-0.6	-1.1	-2.1	-2.6	-2.1	1.9	-0.2	0.5	-1.4	-0.6
Number of live births	1.5	2.1	5.3	1.8	-2.3	-1.1	-1.1	-1.3	-1.4	-1.9	1.2	1.7	0.1	-0.5	1.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	7.8	-2.3	0.4	0.3	-0.5	-2.8	-1.5	-0.7	1.0	-1.1	0.0	-0.2	-1.1
Pulse rate	0.1	0.2	1.0	0.4	-0.8	0.4	-0.1	0.3	0.3	-0.2	0.4	-1.0	-0.2	0.7	-0.4
Happiness	0.7	0.9	3.2	1.8	0.6	0.9	0.9	0.9	1.3	1.0	-0.1	-0.2	0.3	1.3	0.7
Noisy workplace	0.3	0.3	3.1	-0.1	-0.0	0.5	-0.0	0.5	0.1	-0.3	-0.1	-1.8	0.2	0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.7	1.5	8.6	1.3	2.1	0.5	0.3	0.8	0.1	2.9	1.0	-1.0	-0.4	0.2	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.8	0.7	0.8	-0.1	-0.1	-0.4	-0.5	0.8	1.7	0.3	0.9	0.1	1.5
Mouth/teeth dental problems: Dentures	0.7	1.2	5.2	0.2	-2.3	-0.8	-1.0	0.6	-0.6	-2.1	-0.4	0.1	-1.1	-0.9	-0.7
Asthma	0.6	1.3	6.4	2.5	0.3	-1.6	-0.9	-0.7	-1.0	0.8	1.2	0.7	0.9	0.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.7	-1.0	-1.2	-0.8	-1.1	0.3	0.7	-0.8	0.6	2.2	0.7	0.3	0.1
Medication: Cholesterol lowering	3.3	5.2	11.2	1.0	-3.3	-3.4	-2.9	-0.7	-1.7	-2.9	-0.8	2.4	-2.1	-2.5	-1.2
Depression (self-reported)	0.3	0.3	2.0	-0.1	-0.4	-0.6	0.2	0.0	0.3	-0.3	-0.7	1.4	0.4	0.1	0.6
Medication: Lansoprazole	0.6	0.7	2.4	-0.2	-1.1	-1.0	-0.3	-1.5	-0.9	-0.9	-0.1	1.5	-0.3	-0.3	0.1
Prospective memory result	0.2	0.3	1.1	-0.5	-0.4	-0.0	-0.9	-0.4	0.1	-0.6	-1.1	0.1	-0.4	-0.3	-0.3
Lung cancer (father)	1.0	1.1	3.6	0.1	-1.6	-0.4	-0.6	-1.4	-0.3	-1.2	1.0	1.9	0.2	-0.9	1.2
Illnesses of mother	1.6	1.9	4.5	2.1	1.2	0.8	1.0	1.3	1.2	1.4	1.5	0.1	1.7	1.5	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	8.2	-2.9	-0.3	-0.2	-1.3	-2.9	-1.6	-1.2	1.6	-0.4	0.5	0.2	-0.5
Pulse wave Arterial Stiffness index	0.5	0.6	2.4	1.5	0.2	-0.2	-0.4	-0.3	-0.6	-0.2	1.1	0.2	0.4	-0.7	1.4
Impedance of arm (left)	1.1	5.0	17.1	-3.0	-3.5	-1.5	-1.3	-0.6	-1.7	-4.1	-1.2	2.3	-1.5	-2.0	-1.0
Arm fat mass (right)	0.2	0.6	1.7	1.3	1.3	-1.1	-0.6	0.0	-0.4	0.8	0.7	-0.9	0.2	0.1	0.4
Trunk predicted mass	0.6	3.5	13.9	1.8	3.7	0.5	0.8	0.4	0.9	3.7	1.6	-1.5	1.2	1.2	1.6
Standing height	0.1	0.7	3.3	-1.2	1.8	-0.4	-0.2	0.4	0.6	1.5	0.1	0.1	-0.8	-0.6	-0.0
Length of working week for main job	1.0	1.1	3.6	0.9	-0.4	0.5	0.4	1.1	1.3	-0.2	-0.6	0.8	1.6	1.1	1.9
Exposure to tobacco smoke at home	0.6	0.7	3.0	0.4	-0.2	-1.7	-1.4	-0.3	-0.8	0.3	1.4	0.3	-0.2	-0.1	0.3
Breastfed as a baby	0.7	0.9	1.7	1.3	1.1	0.4	1.1	-0.1	0.4	1.3	-0.5	-1.3	-1.0	-0.7	-1.0
Tense / ‘highly strung’	0.5	0.8	1.9	0.1	1.1	1.2	1.0	0.5	1.1	1.4	-0.2	-0.5	0.9	1.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	5.0	0.1	-2.2	-0.2	-0.9	0.6	0.3	-1.5	-1.4	0.7	-0.1	0.7	-1.1
Hair/balding pattern: Pattern 4	0.5	1.3	4.1	-0.2	1.9	0.5	1.6	0.1	0.9	1.4	-2.0	-1.3	-0.9	0.0	-0.1
Birth weight of first child	0.6	1.1	4.3	-1.7	0.2	-0.6	-0.8	-0.7	0.1	0.7	1.4	0.5	2.1	1.1	-0.1
Peak expiratory flow (PEF)	0.8	1.8	5.8	-2.3	-0.4	0.1	-0.7	-2.4	-1.7	-1.3	-0.1	-0.7	-0.8	-1.1	-1.7
Pulse wave reflection index	1.1	1.4	4.1	0.3	-1.6	-1.3	-1.4	-1.0	-0.7	-1.8	0.2	2.0	-0.1	-0.9	0.6
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.6	0.3	-0.4	-0.7	-1.1	1.9	1.5	0.4	-0.3	0.8	1.1	1.3	0.1
Loud music exposure frequency	0.1	0.1	0.5	-0.1	0.1	-0.4	-0.3	0.3	-0.0	-0.1	-0.5	-0.0	0.1	0.7	-0.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.7	1.6	1.0	0.7	-0.2	0.7	0.9	1.6	1.2	-0.2	1.5	1.1	1.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	1.2	1.0	0.4	1.1	-1.0	-1.2	0.7	1.3	0.1	-0.3	-0.8	-0.0
Blood clot in the leg (DVT)	0.6	0.7	2.1	0.4	-1.1	-1.0	-1.0	-0.3	-1.0	-1.4	0.3	0.7	0.2	-1.4	0.1
Medication: Paracetamol	1.0	1.6	4.9	-1.3	-2.2	-1.7	-2.1	-0.1	0.0	-1.7	-0.6	1.5	0.2	0.3	-0.1
Headache pain in last month	0.6	1.1	3.3	1.6	-0.4	-1.2	-1.0	-0.0	0.5	1.1	1.8	0.5	0.4	1.2	1.2
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	12.6	0.0	3.5	2.7	2.8	-0.4	0.4	3.4	2.5	-1.2	2.4	1.1	2.4
Glaucoma (self-reported)	0.9	1.1	4.4	2.1	1.2	-0.9	-0.4	0.7	0.9	1.9	0.1	-0.7	-0.0	0.7	0.1
Gout (self-reported)	0.3	0.4	2.1	0.4	0.7	0.8	1.0	0.2	-0.4	0.5	0.4	-1.4	-0.6	-0.3	-0.2
Hypothyroidism/myxoedema (self-reported)	2.5	4.8	12.7	-0.4	-3.6	-3.2	-3.1	-1.3	-2.5	-2.7	0.4	2.2	-1.3	-1.3	-1.2
Medication: Amlodipine	1.0	1.4	4.9	0.6	-2.2	-1.0	-1.6	0.9	0.4	-1.7	-1.6	0.1	-0.9	0.6	-0.7
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.1	1.1	-0.1	-1.4	-0.9	0.7	-0.5	-0.2	1.4	1.4	1.8	-0.1	0.4
Birth weight	0.4	0.8	4.1	-2.0	-0.6	0.3	-0.8	-0.8	-0.5	-1.1	0.5	0.6	0.9	-0.4	0.8
Chronic bronchitis/emphysema (mother)	1.3	1.5	4.9	-1.6	-1.6	-1.3	-1.5	-0.9	-0.8	-2.2	-1.3	0.9	-0.4	-0.3	-0.6
High blood pressure (siblings)	0.9	1.3	3.8	-0.5	-1.4	-1.8	-1.7	0.8	0.7	-1.2	-2.0	0.4	-0.7	0.4	-0.5
Forced vital capacity (FVC), Best measure	0.6	2.2	6.9	-1.9	1.7	1.4	0.9	-2.6	-1.5	0.7	1.4	-2.0	0.2	0.4	-1.1
Body fat percentage	0.1	0.3	1.3	0.7	-0.1	-1.1	-0.7	0.3	-0.5	-0.9	-0.4	-0.2	-0.2	-0.3	-0.2
Leg fat percentage (right)	0.2	0.6	2.0	0.9	-1.0	-1.0	-1.0	0.6	-0.5	-1.4	-0.7	0.1	-0.2	-0.2	-0.2
Arm fat-free mass (right)	0.9	4.6	16.0	2.2	4.0	1.0	1.2	0.5	1.5	4.0	1.3	-1.7	1.6	1.7	1.9
Exposure to tobacco smoke outside home	0.7	1.0	2.5	-1.4	1.3	-0.4	0.6	1.2	1.1	1.1	-1.6	0.0	0.2	1.1	-0.1
Comparative body size at age 10	0.5	1.4	4.6	0.7	-0.3	-0.4	-0.4	-1.9	-1.9	-1.1	1.5	0.2	-0.5	-2.2	-0.2
Number of full brothers	3.2	4.0	12.3	-0.8	-3.5	-2.7	-3.5	-0.3	-0.1	-2.6	-0.2	2.8	-0.4	-0.4	0.9
Worry too long after embarrassment	0.6	1.0	4.5	0.9	-0.1	1.7	0.6	0.2	0.4	0.9	-0.5	-2.1	-1.3	0.9	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	5.7	-1.0	-2.4	-0.7	-0.5	-0.2	-0.4	-2.0	-0.6	1.6	-0.1	0.0	-1.0
Wheeze or whistling in the chest in last year	0.5	0.9	2.5	1.6	-1.5	-0.3	-0.3	0.8	0.4	-0.4	0.9	0.7	1.5	1.1	0.7
Number of children fathered	0.3	0.4	1.3	-0.7	-0.3	0.5	0.4	1.2	-0.4	-0.4	-0.6	-0.6	-0.4	-0.0	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	6.1	-1.1	1.2	2.3	2.5	-0.5	0.0	1.4	1.0	-1.3	1.1	1.4	0.2
Age at first live birth	1.0	1.7	5.6	1.2	2.1	0.6	0.9	1.2	0.7	2.4	0.5	-1.6	0.2	1.0	-1.4
Pulse wave peak to peak time	0.6	0.6	1.7	-1.3	0.2	0.4	0.7	0.6	0.9	0.6	-1.1	-0.3	-0.2	0.9	-1.2
Health satisfaction	1.3	1.7	5.4	1.3	-0.3	-0.2	-0.7	2.2	1.6	0.6	0.2	0.2	1.8	2.3	1.1
Shortness of breath walking on level ground	1.1	1.3	2.9	-1.7	-1.1	-1.7	-1.6	0.1	0.0	-1.1	-0.3	1.7	1.3	0.5	0.7
Qualifications: College or University degree	0.2	0.5	1.8	0.7	0.9	-0.2	0.4	-1.3	-0.5	1.1	0.8	-0.1	0.2	-0.2	-0.6
Eye problems/disorders: None of the above	0.3	0.3	0.9	-0.0	0.2	0.4	0.5	0.7	0.5	0.3	1.0	-0.2	0.5	0.8	0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.9	-0.9	0.3	0.8	0.1	-0.9	-0.7	0.0	0.3	-0.5	0.1	-0.8	0.7
Emphysema/chronic bronchitis	1.3	1.5	4.0	2.0	-0.1	-1.5	-1.6	-0.5	-1.4	0.3	1.3	1.0	0.4	-1.4	1.6
Medication for pain relief, constipation, heartburn	2.0	3.3	10.2	-0.1	2.8	2.7	2.9	0.1	-0.7	2.3	0.6	-3.2	0.1	0.1	0.2
Neck or shoulder pain in last month	0.3	0.4	2.3	1.5	-0.7	-0.3	0.1	-0.3	-0.2	-0.3	1.1	0.5	-0.0	-0.2	0.1
Medication: Blood pressure	1.8	3.2	10.3	-0.7	-2.0	-0.8	-1.3	1.8	1.3	-2.1	-3.2	-0.5	-1.7	0.5	-2.9
Angina (self-reported)	2.0	2.7	7.3	2.1	-1.4	0.6	0.6	-0.8	-0.2	-1.8	-1.6	0.8	-2.7	-2.3	-2.3
Migraine (self-reported)	0.6	0.7	3.5	-0.2	0.2	-0.1	-0.1	0.8	1.0	0.4	0.3	0.3	1.9	1.4	1.0
Medication: Ibuprofen	1.2	1.4	7.3	-1.6	-1.5	-0.9	-1.3	-0.1	0.4	-1.4	0.3	2.7	0.0	-0.5	-0.3
Medication: Allopurinol	0.1	0.2	0.4	0.6	-0.1	0.5	0.5	0.4	-0.2	-0.2	0.3	-0.3	-0.0	-0.5	0.5
Medication: Omeprazole	0.5	0.6	2.8	-0.9	-1.7	-0.0	-0.6	-0.7	-0.1	-1.2	-1.0	0.5	-0.6	0.2	0.1
Medication: Seretide 50 evohaler	0.7	0.8	3.1	1.8	0.9	-1.4	-1.3	0.1	0.2	1.1	-0.1	0.1	0.1	0.9	-0.7
Mean time to correctly identify matches	1.2	2.2	9.9	0.7	-3.1	-0.8	-1.2	1.2	1.1	-2.2	-0.5	1.6	0.8	1.6	0.7
Heart disease (mother)	2.0	2.4	7.5	-1.9	-0.6	-0.4	-0.1	-0.4	-0.5	-0.6	-2.7	-0.1	-2.7	-1.8	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.6	-0.1	-1.1	0.1	-0.3	-0.7	-1.5	-0.9	0.2	-0.4	-1.9	-1.9	-0.9
Whole body fat mass	0.1	0.3	1.4	1.2	0.8	-0.9	-0.5	0.6	0.1	0.2	0.2	-0.5	0.2	0.2	0.5
Leg fat mass (right)	0.1	0.4	1.8	1.3	0.7	-0.7	-0.6	0.8	0.2	0.3	0.1	-0.4	0.4	0.4	0.5
Arm predicted mass (right)	0.8	4.3	15.7	2.0	4.0	1.1	1.3	0.7	1.6	3.9	1.1	-1.7	1.4	1.6	1.6
Pulse rate, automated reading	0.6	2.0	6.5	0.1	-0.7	0.7	0.5	2.4	2.5	0.6	-1.6	-1.1	0.5	2.5	-0.6
Alcohol intake frequency.	0.7	1.7	5.7	-0.3	-1.9	-2.4	-2.4	-1.0	-0.7	-1.2	-0.0	1.2	-0.6	-0.9	0.3
Comparative height size at age 10	0.1	0.7	1.4	-1.2	0.2	-0.8	-1.1	0.9	1.2	-0.4	0.1	0.9	0.4	0.5	1.0
Number of full sisters	0.5	0.6	2.8	-0.4	-1.7	0.2	-0.4	-0.0	-0.7	-1.0	0.5	0.1	-0.4	-0.5	1.2
Suffer from ‘nerves’	0.7	1.0	3.4	0.6	0.7	1.9	1.3	0.8	0.6	0.9	0.7	-0.7	1.0	1.1	1.1
Overall health rating	0.3	0.6	3.7	0.9	-1.3	-0.7	-1.9	0.3	-0.4	-0.5	0.4	-0.0	0.2	0.3	0.1
Chest pain or discomfort	0.6	0.8	1.8	-1.0	-1.0	-1.0	-1.0	-0.4	-0.9	-0.4	-0.7	0.2	-1.3	-1.2	-1.1
Had major operations	0.6	0.7	3.2	0.7	-0.3	-1.4	-1.8	-0.6	-0.4	0.1	0.0	0.9	-0.5	-0.6	-1.1
Age at last live birth	1.7	2.5	4.7	1.4	2.1	1.0	1.6	2.1	1.8	2.2	-0.3	-1.6	0.5	1.4	-1.6
Family relationship satisfaction	0.3	0.3	1.0	0.1	-0.3	0.3	0.3	-0.1	0.2	-0.8	0.6	0.8	0.9	0.4	1.0
Leg pain on walking	2.2	2.7	9.1	0.1	-2.1	-2.7	-3.0	-0.5	-1.0	-2.2	-0.3	1.5	0.5	-0.5	-1.8
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	8.0	-0.0	-2.8	-1.2	-1.8	0.2	-0.2	-2.4	0.8	1.3	1.8	1.1	0.9
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	-0.2	-0.7	0.1	-0.2	0.6	-0.0	-0.1	-0.8	-0.8	-0.2	0.6	-0.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	3.0	0.5	1.7	1.0	0.4	1.0	0.8	1.4	-0.2	-1.1	0.6	0.6	0.1
Medication: Aspirin	2.0	2.7	6.8	1.2	-1.9	-1.2	-1.6	1.3	1.2	-1.7	-2.6	1.2	-1.9	-0.6	-2.2
Supplements: Vitamin C	0.7	0.8	2.3	0.3	1.0	-0.1	-0.3	0.8	1.4	1.5	-0.0	-0.6	0.3	1.5	0.7
Knee pain experienced in last month	0.4	0.6	3.1	0.4	-1.8	0.4	-0.2	0.7	0.5	-0.7	0.8	0.7	0.5	1.0	-0.3
Hypertension (Self-reported)	2.1	5.8	20.8	-0.5	-4.6	-2.2	-3.8	-0.0	-1.3	-4.2	-1.8	0.3	-1.9	-0.6	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.3	-0.8	-1.1	-0.5	-0.7	-0.6	-0.2	-0.3	-0.0	0.2	-0.4	0.2	-0.4
Illnesses of father: Heart disease	0.4	0.6	2.4	-0.2	-0.7	-1.6	-0.6	-0.0	-0.4	-0.5	-0.8	0.9	-0.9	-0.8	-0.3
Illnesses of siblings: Diabetes	0.7	0.9	3.4	1.2	-1.3	-1.8	-1.2	0.5	0.7	-1.1	0.5	0.3	-0.5	0.1	-0.4
Smoking status: Previous	1.0	1.5	6.0	-0.7	-1.6	-0.1	-0.0	-0.4	-0.7	-1.2	-1.7	-0.3	-1.9	-0.7	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	3.5	-1.9	0.7	-1.1	-0.3	-0.4	-0.2	0.2	0.1	1.5	-0.2	-0.5	-0.8
Whole body fat-free mass	0.9	4.9	18.1	2.3	4.2	0.8	1.2	0.7	1.5	4.3	1.6	-1.9	1.3	1.7	1.6
Leg fat-free mass (right)	1.3	6.9	23.5	2.6	4.8	1.2	1.8	1.2	2.0	4.8	1.9	-2.4	1.6	2.3	1.8
Arm fat percentage (left)	0.1	0.3	1.3	1.1	0.5	-0.8	-0.3	0.3	-0.3	-0.1	0.3	-0.8	0.6	0.5	0.4
Average weekly red wine intake	0.7	1.1	5.1	0.6	1.7	0.4	1.5	1.0	0.7	2.2	0.2	-0.2	0.6	0.4	-0.3
Handedness (chirality/laterality): Left-handed	0.9	1.0	2.7	0.5	1.6	1.0	0.8	0.7	1.0	1.6	0.8	0.5	1.2	0.8	1.1
Mood swings	0.3	0.5	1.4	1.0	0.2	1.1	0.9	-0.1	-0.2	0.5	0.5	-0.2	1.0	0.6	1.2
Loneliness, isolation	0.5	0.8	2.9	1.7	0.2	0.9	0.9	0.2	0.8	0.7	-0.0	-1.2	0.5	1.3	0.2
Long-standing illness, disability or infirmity	0.4	0.7	2.7	-0.4	-0.7	0.4	-0.8	-0.6	-1.1	-0.4	-0.7	-1.6	-0.8	0.4	-0.9
Ever had bowel cancer screening	0.4	0.5	2.2	1.3	-0.3	0.3	-0.5	0.6	0.0	0.4	0.5	0.4	0.7	0.1	1.5
Diabetes diagnosed by doctor	2.6	4.2	15.4	-0.0	-3.9	-2.4	-3.3	-1.1	-1.9	-3.0	0.6	1.8	-0.7	-1.1	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.4	9.9	1.3	0.7	0.9	-0.6	1.0	1.9	2.0	-0.1	-2.3	0.7	3.2	1.0
Friendships satisfaction	1.2	1.5	5.4	0.4	-0.2	0.5	0.3	-0.4	0.1	0.2	1.4	1.1	2.3	1.7	2.3
Qualifications: nursing, teaching	0.4	0.7	3.4	0.6	1.0	-0.8	-1.1	-1.0	0.1	1.8	0.8	0.1	-0.4	0.2	0.1
Commuting to job workplace: Walk	0.6	0.7	1.9	0.0	1.3	1.4	1.2	-1.2	-0.5	0.6	0.5	-0.5	0.1	-0.5	-0.5
Eye problems/disorders: Cataract	1.1	1.3	3.9	0.7	0.8	1.4	1.2	-2.0	-1.8	0.3	-0.2	-0.6	-0.9	-1.6	0.4
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	7.2	1.1	1.1	0.9	1.0	2.7	1.9	1.8	0.5	-0.3	1.5	2.2	0.2
Medication for cholesterol	0.3	0.4	1.1	0.0	1.0	-0.2	0.9	-0.4	-0.3	0.8	1.0	0.6	0.5	-0.4	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	6.9	0.4	-2.0	-2.6	-2.3	-0.3	-0.2	-1.4	0.3	2.3	-0.3	-0.6	0.5
Back pain experienced in last month	1.6	2.3	5.0	0.2	1.8	1.9	2.0	1.5	2.2	1.4	0.2	-1.4	1.1	1.9	0.2
Mineral and other dietary supplements	0.7	1.0	4.1	-0.0	1.0	2.0	1.8	0.1	-0.0	0.9	0.3	-1.4	-0.5	-0.3	-0.3
Breast cancer (self-reported)	1.8	2.1	10.5	0.0	0.8	-0.7	0.4	-1.8	-1.9	-0.3	-0.8	-0.3	-2.4	-3.2	-0.6
Asthma (self-reported)	0.7	1.3	6.9	2.6	0.4	-1.4	-0.8	-0.5	-0.8	1.2	1.3	0.5	1.1	0.6	0.8
Osteoporosis (self-reported)	0.8	1.0	3.2	0.6	1.7	0.3	0.4	0.1	0.3	1.8	1.2	-1.5	0.5	0.9	-0.0
Osteoarthritis (self-reported)	0.3	0.4	1.8	1.0	-0.0	-0.4	-0.1	0.1	0.3	0.0	-0.1	1.3	0.7	0.3	0.8
Medication: Aspirin	2.3	3.0	7.1	1.1	-2.3	-1.0	-1.7	1.6	1.2	-1.8	-2.7	1.5	-2.0	-0.6	-2.1
Medication: Gliclazide	5.9	6.6	22.1	-0.1	-4.4	-2.4	-3.0	-0.8	-2.3	-4.7	1.2	3.3	1.4	-1.5	0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	2.3	-1.5	-0.3	0.1	0.1	-0.2	0.6	0.0	-1.1	0.8	-0.2	0.1	-1.1
Smoking status: Current	0.4	0.7	2.1	-0.8	-1.5	-0.9	-1.1	-0.4	-0.3	-1.3	-0.2	0.8	0.2	0.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	6.4	-1.7	-0.7	-0.1	-0.6	-2.5	-2.1	-2.1	1.7	-0.1	1.2	-0.4	0.2
Whole body water mass	0.9	5.1	18.7	2.3	4.3	0.9	1.4	0.6	1.4	4.3	1.6	-2.1	1.2	1.7	1.6
Leg predicted mass (right)	1.3	6.9	23.7	2.6	4.8	1.1	1.7	1.1	2.0	4.9	1.9	-2.4	1.6	2.3	1.8
Arm fat mass (left)	0.2	0.7	2.4	1.5	1.6	-0.7	-0.2	0.2	-0.2	1.1	0.7	-1.1	0.4	0.4	0.6
Number of self-reported non-cancer illnesses	1.2	2.1	7.9	0.2	-2.8	-1.0	-2.1	-0.7	-1.8	-2.2	-0.5	0.2	-1.1	-0.9	-0.7
Average weekly champagne plus white wine intake	0.8	1.1	3.9	0.8	1.4	2.0	2.0	-0.0	-0.4	0.4	1.0	-0.6	0.8	-0.4	0.3
Miserableness	1.0	1.7	6.1	0.5	0.4	1.6	1.4	1.0	1.2	1.0	-0.1	-0.3	2.0	2.5	1.3
Guilty feelings	0.7	1.0	3.5	0.4	-1.5	-1.9	-1.5	0.8	-0.2	-0.1	-0.2	1.1	-0.9	-0.4	-0.8
Wears glasses or contact lenses	0.3	0.4	1.4	-0.9	0.5	-0.4	0.8	0.4	0.0	-0.6	-0.0	0.4	1.2	-0.3	-0.7
Ever taken oral contraceptive pill	1.0	1.1	4.7	-0.5	-0.5	-0.7	-0.3	-1.9	-0.7	0.0	-0.1	-0.9	-1.5	-0.5	-2.2
Hearing aid user	0.5	0.6	2.1	0.9	-0.8	-0.5	-0.4	-0.3	-0.8	-0.6	1.5	0.6	1.1	-0.3	0.6
Mother’s age at death	1.6	1.9	7.2	1.9	2.5	0.4	1.3	1.0	1.4	2.7	0.5	-1.2	-0.1	0.3	0.0
Financial situation satisfaction	1.2	1.5	5.3	0.4	-0.9	0.6	-0.1	0.6	0.5	-0.7	0.8	2.1	2.3	1.0	2.0
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.1	0.7	-0.4	-0.8	-0.5	-1.0	-1.8	-0.3	1.1	-0.2	-0.1	-0.7	-0.7
Commuting to job workplace: Public transport	0.4	0.4	1.8	0.2	-0.0	0.5	0.1	-1.3	-1.1	-0.6	0.7	0.2	-0.3	-0.9	-0.4
Eye problems/disorders: Glaucoma	0.4	0.5	1.7	1.0	0.0	-1.3	-1.1	0.6	1.0	0.5	-0.3	-0.1	0.2	0.6	-0.4
Medication: Blood pressure	0.7	1.3	4.1	-0.2	-1.9	-0.7	-2.0	-0.8	-1.1	-1.9	-0.2	-0.2	-1.0	-0.9	-0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.2	0.6	-0.5	1.1	0.2	0.3	0.2	-0.1	-0.1	-0.3	0.9	0.7	-0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.0	-0.3	-0.3	-1.3	-1.3	0.3	0.3	-0.1	-0.7	1.4	0.1	-0.0	0.4
High cholesterol (Self-reported)	1.7	3.1	10.6	0.0	-3.2	-1.6	-2.1	0.1	-0.9	-2.7	-0.9	2.1	-1.7	-1.7	-0.0
Medication: Bendroflumethiazide	0.8	1.1	4.2	-0.2	-1.1	-1.3	-2.1	-0.6	-1.0	-1.1	0.1	-1.3	-0.6	-0.5	-1.4
Medication: Paracetamol	1.4	2.1	4.8	-1.7	-2.2	-1.9	-2.2	-0.6	-0.7	-2.0	-0.1	2.0	-0.1	-0.8	-0.3
Medication: Lisinopril	0.6	0.8	1.8	0.9	-1.0	-0.1	-1.3	-1.1	-1.2	-1.4	1.1	-0.5	0.0	-0.5	-0.1
Medication: Atorvastatin	1.2	1.4	3.5	1.4	-1.2	-1.8	-1.2	0.0	-0.5	-0.6	-0.4	1.9	-1.7	-1.5	-0.4
Illnesses of father: High blood pressure	0.7	0.9	3.0	-0.4	0.5	-0.2	-1.0	1.3	1.4	0.3	-0.7	-1.0	0.9	1.7	0.5
Alcohol drinker status: Never	1.6	1.9	5.0	-1.2	-2.0	-1.8	-2.0	-0.9	0.1	-1.8	0.1	2.2	0.3	-0.8	0.7
Ever smoked	0.6	1.1	2.2	-1.2	-0.2	1.3	1.5	-1.2	-1.0	-0.1	-1.1	-1.5	-0.5	-0.0	-1.2
Basal metabolic rate	0.8	4.2	15.6	2.1	4.0	0.7	1.1	0.7	1.3	3.9	1.3	-1.9	1.0	1.5	1.4
Leg fat percentage (left)	0.1	0.3	0.8	0.9	-0.4	-0.8	-0.6	0.7	-0.2	-0.9	-0.5	-0.2	0.1	0.1	-0.4
Arm fat-free mass (left)	0.7	3.4	14.3	1.7	3.8	0.6	1.0	0.4	1.0	3.7	1.2	-1.7	0.9	1.1	1.2
Number of operations (self-reported)	0.6	0.9	2.6	0.3	-1.3	-0.7	-0.6	-0.4	-0.9	-1.4	-1.0	1.0	-0.1	-0.8	-1.6
Average weekly beer plus cider intake	0.4	0.5	1.8	-0.6	-1.3	-0.4	-0.2	-0.5	-1.2	-1.2	0.4	0.8	0.0	-0.2	0.4
Irritability	0.4	0.6	2.3	-0.8	1.5	0.8	0.5	0.5	0.5	1.2	-0.1	-0.2	1.0	0.7	0.2
Risk taking	0.1	0.2	0.6	-0.8	-0.3	-0.5	-0.2	0.1	0.4	0.4	0.1	0.6	0.2	0.0	-0.7
Ever had prostate specific antigen (PSA) test	2.2	2.5	8.7	-1.5	-2.5	-1.8	-2.0	1.1	0.7	-1.5	-0.8	2.9	-0.2	0.5	0.7
Fractured/broken bones in last 5 years	1.7	2.2	7.3	-1.9	-1.2	-2.1	-2.0	0.7	1.0	-0.9	-1.6	2.7	-0.3	-0.1	0.9
Age started oral contraceptive pill	0.5	0.6	3.3	1.8	0.8	0.1	0.1	1.2	0.8	0.7	-0.3	-0.2	-0.4	-0.6	0.7
Diastolic blood pressure, automated reading	3.0	9.3	29.8	-0.8	-5.3	-4.2	-5.5	-0.3	-2.2	-4.5	0.4	2.7	-0.7	-1.3	0.4
Ever depressed for a whole week	0.3	0.4	2.1	0.9	0.1	0.3	0.1	-0.1	0.8	0.2	-0.2	-0.1	0.9	1.5	-0.4
Unable to work because of sickness or disability	1.0	1.3	4.2	-1.0	-1.9	0.6	-0.1	0.5	0.6	-2.0	-0.7	1.2	1.4	1.1	0.0
Commuting to job workplace: Cycle	0.7	0.8	3.6	-0.3	1.6	1.1	1.2	-0.7	0.2	1.9	-0.3	-0.5	-0.2	-0.3	-0.0
Myopia	0.6	0.8	3.5	0.3	-0.3	-0.1	-0.5	1.7	1.0	0.2	0.5	-0.1	0.8	1.1	1.9
Vascular/heart problems diagnosed by doctor	2.5	6.9	20.5	0.7	4.5	2.4	3.8	0.4	1.7	4.3	2.4	-0.3	2.8	1.5	2.2
Cholesterol lowering medication	0.2	0.3	0.9	0.8	-0.7	0.6	-0.5	1.0	0.5	-0.1	-0.8	-0.3	-0.2	0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	2.6	-0.1	-1.6	-0.2	-0.6	-0.7	-0.3	-0.9	-0.0	0.7	-0.1	0.5	0.5
Pain experienced in last month	0.5	0.8	3.7	0.1	0.4	-0.5	0.3	-1.1	-1.6	0.0	0.5	0.1	-1.1	-1.9	-0.4
Supplements: Calcium	0.9	1.0	4.2	-2.1	-0.6	-0.8	-0.7	0.6	1.1	-0.1	-1.7	0.4	-0.8	0.6	-0.8
Basal cell carcinoma (self-reported)	1.5	1.8	8.7	0.5	-1.0	-1.7	-1.1	-0.8	-0.7	-1.0	-0.9	-0.2	-1.8	-1.3	-3.0
Heart attack/myocardial infarction (self-reported)	2.2	2.8	6.4	-0.8	-1.2	-0.4	0.2	-0.9	-1.9	-2.1	-2.1	0.6	-2.2	-2.5	-2.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.7	0.6	-1.0	-1.0	-1.0	-0.2	-0.9	-1.3	0.1	0.5	-0.1	-1.6	-0.3
Heart disease (siblings)	0.5	0.6	1.7	-0.8	0.4	0.8	1.3	0.5	0.0	0.3	-0.6	-1.0	-1.0	-0.2	-1.2
Alcohol drinker status: Previous	0.5	0.5	1.2	-1.1	-0.8	0.0	-0.1	-1.0	-0.8	-0.8	-0.5	0.5	-0.9	-0.9	-0.4
Pack years of smoking	0.9	1.4	5.6	1.0	-0.2	-0.4	-0.8	2.4	2.1	0.3	-0.8	0.7	0.5	0.9	1.5
Impedance of whole body	1.8	9.2	29.7	-4.0	-4.7	-1.8	-1.9	-1.0	-2.2	-5.5	-2.0	3.1	-2.0	-2.8	-2.0
Leg fat mass (left)	0.1	0.4	1.7	1.3	1.0	-0.6	-0.3	0.9	0.4	0.5	0.1	-0.6	0.5	0.5	0.3
Arm predicted mass (left)	0.7	3.4	13.0	2.0	3.6	0.7	1.0	0.4	1.2	3.6	1.2	-1.6	1.0	1.2	1.2