Hub : Genes

EHD4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.2530 0.0660 1.9e-04 0.003 NA 0.071 NA 0.042 1.9e-01 NA 2.0e-06 NA 2.2e-04
2 GTEx Artery Tibial 0.1355 0.0426 8.0e-05 0.034 NA 0.063 NA 0.047 1.1e-03 NA 1.0e-05 NA 1.4e-04
3 GTEx Brain Cerebellar Hemisphere 0.2470 0.0990 3.3e-03 0.168 NA 0.106 NA 0.132 4.4e-05 NA 1.1e-03 NA 2.9e-04
4 GTEx Brain Cerebellum 0.3650 0.1040 6.7e-05 0.314 NA 0.225 NA 0.286 5.5e-10 NA 2.9e-07 NA 4.3e-09
5 GTEx Heart Atrial Appendage 0.2920 0.0770 1.5e-04 0.144 NA 0.046 NA 0.099 5.3e-07 NA 3.8e-03 NA 3.5e-05
6 GTEx Heart Left Ventricle 0.2026 0.0723 1.7e-03 0.140 NA 0.081 NA 0.118 6.4e-08 NA 4.3e-05 NA 7.8e-07
7 GTEx Nerve Tibial 0.2004 0.0613 4.7e-05 0.043 NA 0.063 NA 0.081 5.3e-04 NA 3.0e-05 NA 2.4e-06
8 METSIM Adipose 0.0965 0.0412 1.9e-03 0.047 0.003 0.025 0.030 0.032 1.4e-07 1.0e-01 9.2e-05 2.4e-05 1.0e-05
9 YFS Blood 0.4818 0.0398 0.0e+00 0.346 0.403 0.436 0.427 0.434 7.9e-119 8.5e-144 2.1e-159 6.0e-155 2.6e-158
10 TCGA Breast Invasive Carcinoma 0.0370 0.0139 4.4e-04 0.020 0.017 0.008 NA 0.013 5.4e-05 1.4e-04 7.1e-03 NA 8.6e-04
11 TCGA Kidney Renal Clear Cell Carcinoma 0.0508 0.0223 2.0e-03 0.022 0.037 0.034 NA 0.034 1.5e-03 4.2e-05 8.8e-05 NA 8.6e-05
12 TCGA Prostate Adenocarcinoma 0.1744 0.0462 8.4e-08 0.088 0.092 0.079 NA 0.079 1.7e-09 6.8e-10 1.1e-08 NA 1.1e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.9 1.4 3.6 -0.2 1.4 0.1 0.3 0.1 1.2 1.7 -1.0 -1.9 -1.9 0.2 -1.3
Bipolar Disorder or Schizophrenia 0.4 1.0 3.3 1.5 1.4 0.1 0.0 0.1 0.1 1.8 1.3 -1.4 -0.4 0.7 0.0
Depressed Affect (Nagel 2018) 0.7 1.4 5.3 1.4 0.1 1.0 1.5 0.8 0.8 0.3 0.7 0.9 2.3 1.7 0.9
Depression (Nagel 2018) 0.8 1.2 4.1 2.0 -1.1 -0.4 -0.6 -1.2 -0.6 -0.7 1.6 0.7 1.7 0.6 0.6
Intelligence (Savage-Jansen 2018) 0.8 2.6 7.3 2.7 1.9 -0.1 -0.2 -0.9 -1.6 2.3 0.8 -2.2 -1.2 -1.7 1.0
Neuroticism (Nagel 2018) 0.5 1.1 4.3 0.8 -0.2 1.1 0.7 0.1 -0.1 0.4 1.5 0.0 2.1 1.6 1.1
Schizophrenia (2018) 0.6 1.3 6.1 2.1 0.7 0.0 -0.2 0.1 -0.9 0.9 2.5 -0.3 1.1 0.8 1.2
Schizophrenia vs Biploar Disorder 0.6 0.8 2.0 0.5 0.1 0.8 0.4 -0.3 -1.4 -0.9 1.4 0.2 1.4 -0.3 1.3
Worry (Nagel 2018) 0.8 1.7 5.5 0.6 1.1 2.4 1.7 0.2 0.4 1.4 1.0 -0.8 1.6 1.6 1.4
Alzheimer’s Disease (in mother) 0.2 0.3 0.8 -0.4 -0.1 0.9 0.1 -0.5 -0.5 -0.5 -0.7 -0.2 -0.7 -0.9 -0.1
Alzheimer’s Disease (in father) 0.9 1.0 4.8 0.2 0.7 1.8 2.2 -0.1 -0.4 0.2 0.3 -1.6 -0.0 0.4 -0.4
Alzheimer’s Disease (including proxy) 0.3 0.4 1.5 -0.4 0.5 1.2 0.9 -0.2 -0.4 -0.1 -0.3 -0.9 -0.7 -0.9 -0.2
Crohns Disease (2017) 0.4 0.9 4.6 0.1 0.9 -0.0 0.8 0.9 1.1 0.9 -1.0 -0.2 -0.6 0.1 -2.1
Irritable Bowel Disease (IBD) 0.6 1.4 3.4 0.4 1.1 -0.0 1.0 1.6 1.6 1.8 -0.2 -0.5 0.3 1.8 -1.5
Ulcerative Colitis (UC) 0.7 1.3 7.6 -0.3 0.1 0.1 0.7 1.3 1.4 1.2 0.3 -0.1 1.3 2.8 -0.5
Major Depression (MDD) 0.6 0.7 3.0 -1.1 -1.7 0.2 -1.3 0.4 0.2 -1.2 -0.9 -0.2 -0.2 0.6 0.3
Reaction Time 1.8 3.3 15.7 -1.1 -4.0 -0.7 -1.5 0.9 1.0 -3.1 -0.7 1.9 1.0 1.8 0.8
Verbal and Numeric Reasoning (VNR) 0.9 2.2 10.2 3.2 1.6 -0.7 -0.7 0.5 -0.1 2.6 0.6 -1.9 -0.9 -0.9 0.6
Breast Cancer 1.6 3.8 11.3 0.7 2.4 3.4 2.0 1.4 1.4 1.8 1.1 -2.0 2.0 1.4 2.5
Ovarian Cancer 0.8 1.1 3.9 0.6 -1.8 -0.3 -0.8 0.2 -0.1 -1.8 -0.6 2.0 0.8 0.3 0.8
Prostate Cancer 0.7 1.0 2.8 -1.4 -1.2 -1.1 -0.7 0.6 0.6 -0.4 -1.7 1.7 -0.8 0.2 0.4
Age at First Birth 0.5 0.7 1.6 0.9 0.1 -0.6 0.2 -0.4 -1.3 1.2 0.4 -0.5 -1.1 -0.7 -1.3
Bipolar Disorder (2011) 0.1 0.1 0.5 -0.2 0.4 0.2 -0.3 -0.4 0.7 0.5 0.0 -0.5 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 3.0 0.9 1.3 0.5 0.7 -0.3 0.1 1.0 0.7 -1.7 0.1 -0.3 0.8
Coronary Artery Disease (CAD) 1.3 1.5 5.3 -0.3 -1.4 -0.9 -1.2 -1.4 -2.3 -1.7 0.4 -0.1 -0.9 -1.2 -1.2
Crohns Disease (2012) 1.1 1.8 4.1 0.3 1.9 1.4 1.8 0.8 0.8 2.0 -0.8 -1.9 -1.1 -0.2 -1.5
Mean Putamen Volume 0.3 0.3 1.3 0.7 0.3 -0.3 0.1 0.1 -0.1 1.1 0.1 -1.1 -0.6 0.1 -0.2
Fasting Glucose 0.5 0.6 1.4 0.5 -1.2 -1.0 -1.1 -0.9 -0.8 -0.8 0.3 0.6 -0.2 -0.5 0.8
HbA1C 0.6 0.7 2.7 -0.1 -0.6 -1.1 -0.6 0.2 -0.8 0.1 0.5 0.6 -1.6 -1.5 0.0
HDL Cholesterol 1.3 2.1 6.1 0.5 2.5 1.0 2.0 1.9 1.3 2.4 -0.4 -1.1 -0.1 1.0 -0.7
LDL Cholesterol 0.2 0.3 1.4 0.9 -0.4 -0.2 -0.1 0.1 -0.1 0.2 1.2 0.7 0.4 -0.0 0.6
Lupus 0.7 1.1 3.5 -1.5 -0.3 -0.5 -0.5 -1.9 -1.6 -0.6 1.5 -0.3 -1.0 -0.9 0.1
Neuroticism (2016) 1.1 1.7 5.7 -0.1 -1.9 -0.8 -2.4 0.5 -0.1 -1.1 0.6 1.7 1.3 0.7 1.8
Primary Biliary Cirrhosis 0.1 0.2 0.8 -0.1 -0.3 -0.6 -0.3 0.7 0.5 -0.2 -0.9 0.2 -0.3 0.2 -0.0
Rheumatoid Arthritis 0.7 0.9 3.1 -1.5 -0.3 0.5 0.4 0.6 0.3 -0.8 -1.2 -1.4 -0.4 0.7 -1.8
Schizophrenia (2014) 0.6 1.3 6.1 2.5 0.9 -0.3 -0.2 -0.8 -1.3 1.1 1.9 -1.1 0.0 0.2 -0.3
Triglycerides 2.3 3.8 13.6 0.2 -3.7 -2.2 -3.0 -1.0 -1.2 -2.7 0.5 2.2 -0.3 -0.6 1.4
Type 2 Diabetes (T2D) (2012) 1.0 1.2 4.0 -2.0 -1.0 0.1 -0.3 -1.6 -1.6 -1.1 -0.1 1.0 -0.2 -1.2 -0.4
Ulcerative Colitis 0.8 1.1 4.1 0.0 0.9 0.8 1.0 1.0 0.9 1.3 0.5 -1.5 0.8 2.0 -0.7
Blood Eosinophil Count 2.4 18.4 36.4 -1.4 -4.4 -6.0 -5.1 -3.0 -3.9 -5.1 -3.3 3.1 -4.7 -5.2 -4.2
Blood Platelet Count 2.1 24.9 75.8 -2.6 -4.7 -0.3 -0.9 -1.9 -2.7 -5.9 -8.7 -1.0 -8.1 -5.4 -7.1
Blood Red Count 1.0 9.3 29.7 -3.8 -4.9 -2.9 -3.3 -0.9 -1.3 -5.5 -2.1 2.8 -1.6 -2.4 -1.1
Blood White Count 6.7 50.0 182.2 -8.3 -8.0 -2.9 -2.1 0.4 -0.8 -9.2 -13.5 1.6 -8.9 -4.6 -9.2
Heel T-Score 1.1 8.6 33.5 1.3 -1.0 0.7 1.0 -4.5 -5.4 -2.5 2.5 -0.2 -2.1 -5.8 -0.6
BMI 0.3 2.0 7.0 2.6 2.6 -0.2 0.3 0.9 0.9 2.0 0.5 -0.9 1.3 0.8 0.9
Height 0.3 5.0 16.8 -2.5 -0.8 -4.1 -3.2 0.1 -0.1 -0.8 -0.7 3.3 -2.7 -2.4 -0.8
Waist Hip Ratio (WHR) 3.1 13.9 45.3 -3.5 -6.7 -3.3 -4.7 -2.0 -2.6 -6.7 -0.8 3.3 -1.7 -2.3 -1.2
Systolic Blood Pressure 3.0 15.0 32.9 -2.7 -5.7 -3.3 -4.9 -3.8 -5.2 -5.6 -0.3 0.9 -3.9 -4.0 -1.0
Smoking Status 0.9 2.2 6.4 -0.8 -2.5 -1.6 -1.5 -1.2 -1.4 -2.3 -0.7 1.5 -1.1 -1.3 -0.7
Allergy or Eczema 0.7 2.0 12.3 3.5 0.6 -2.0 -1.1 0.5 0.4 0.6 0.4 1.8 0.6 0.2 0.9
Cardiovascular Disease 2.4 7.9 22.4 -1.6 -4.7 -3.4 -4.7 -1.3 -2.1 -4.7 -1.4 1.1 -1.1 -1.1 -1.1
Hypothyroidism (self reported) 2.0 4.6 12.2 -0.7 -3.2 -3.2 -3.5 -0.7 -1.9 -2.3 -0.5 2.4 -1.9 -1.6 -0.9
Respiratory disease 0.8 1.8 6.6 2.6 -0.4 -1.9 -1.1 0.9 0.2 1.1 0.8 1.3 1.0 1.3 1.5
Type 2 Diabetes (T2D) (2018) 1.7 3.2 11.6 -1.0 -3.4 -1.9 -2.6 -1.4 -1.6 -2.7 0.4 1.7 -0.4 -0.9 -0.2
Lung FEV1/FVC ratio 3.6 18.5 71.9 -3.2 -5.8 -6.2 -8.5 -2.8 -2.5 -5.8 -0.5 3.5 -1.0 -2.2 0.3
Lung FVC 0.9 4.6 22.1 0.5 2.7 2.7 2.7 -1.9 -1.1 0.9 1.4 -4.7 0.5 0.6 -1.7
Neuroticism 1.2 2.9 5.2 1.9 1.5 2.1 1.7 1.3 1.3 2.2 0.9 -0.9 2.1 2.3 1.5
Chronotype (morning person) 0.8 1.9 5.9 -0.8 1.7 2.4 2.0 -0.2 0.7 0.9 0.3 -1.8 1.3 1.4 1.0
Hair Pigment 0.0 1.3 3.8 -1.3 -0.6 0.7 0.2 -1.9 -1.8 -0.7 1.6 -0.6 1.0 0.1 1.1
Tanning 0.1 0.6 1.7 -1.3 -0.4 0.1 1.0 0.1 0.6 -0.8 -1.2 0.3 0.5 0.5 -1.2
Hand grip strength (left) 0.1 0.3 1.0 -1.0 0.8 0.5 0.8 -0.4 0.1 -0.2 -0.2 -0.1 0.7 0.2 -0.2
Number of treatments/medications taken 3.3 6.0 17.9 0.0 -3.6 -3.8 -4.2 -0.3 -1.2 -2.7 -1.1 3.3 -1.3 -1.5 -1.4
Average weekly spirits intake 0.5 0.6 1.7 -1.0 0.1 0.5 1.1 -1.3 -0.9 -1.0 1.0 -0.1 0.2 -0.3 -0.5
Sensitivity / hurt feelings 0.4 0.7 3.6 -0.3 -0.5 1.2 -0.1 -0.8 -0.3 -0.3 0.6 -1.9 0.5 0.9 0.8
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.4 0.7 -1.4 -0.6 -1.2 -0.9 -0.5 -1.1 1.1 0.7 1.5 0.5 1.1
Hearing difficulty/problems: Yes 0.8 1.2 5.3 -0.4 1.3 0.3 0.8 -1.1 -1.4 0.7 0.3 -1.1 -0.5 -0.9 -2.3
Relative age of first facial hair 0.5 1.0 4.1 -0.1 -2.0 -1.1 -0.6 -0.3 -0.8 -1.7 -0.8 1.4 -0.4 -0.3 -0.5
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 3.9 -0.4 -1.4 -1.3 -1.7 -1.8 -1.9 -0.9 -0.3 -0.5 -1.4 -0.8 -2.0
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.6 1.0 -0.1 -0.2 -1.0 1.3 0.9 0.7 -0.4 -0.3 0.1 0.7 1.1
Ever had hysterectomy (womb removed) 1.4 1.6 3.1 -0.3 -1.7 0.0 -0.5 1.5 1.8 -1.0 -1.7 1.1 1.4 1.3 1.3
Systolic blood pressure, automated reading 2.3 6.6 18.5 -0.8 -3.2 -2.2 -3.1 -2.8 -4.3 -3.4 0.6 1.5 -1.8 -3.1 0.9
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 7.2 0.0 -1.5 -0.4 -0.3 2.7 2.3 -0.9 -2.0 2.1 -0.3 1.2 -0.0
Angina 1.9 2.5 6.4 1.9 -1.6 0.4 0.3 -0.4 -0.0 -2.0 -1.5 1.0 -2.5 -2.2 -2.2
Medication for hormone replacement therapy 1.0 1.1 2.6 1.5 0.9 1.0 1.3 1.6 1.0 1.1 -1.0 -0.7 -0.4 0.6 -0.6
Vitamin and mineral supplements 1.0 1.4 3.7 -0.4 0.4 1.1 1.0 -1.8 -1.7 -0.8 0.4 -0.6 -1.4 -1.9 -0.9
Supplements: Zinc 1.3 1.5 5.8 -0.3 -1.1 -0.7 -1.6 1.6 2.4 -0.3 -1.2 0.0 0.1 1.8 -0.3
Medication: Co-codamol 0.9 1.0 3.4 -1.7 -1.4 -0.0 -0.4 0.7 0.0 -1.4 -1.8 0.2 0.8 0.7 -0.5
Medication: Metformin 2.9 4.1 14.3 -0.1 -3.8 -1.9 -2.7 -1.7 -2.3 -3.4 0.5 1.3 -0.4 -1.4 -0.6
Diabetes (father) 3.5 4.3 14.3 -1.5 -1.3 -3.8 -3.5 -2.5 -2.6 -1.0 1.4 0.9 -0.7 -1.6 -1.4
Diabetes (mother) 2.4 3.0 6.7 -1.1 -2.5 -1.1 -2.3 -1.9 -2.6 -2.6 1.7 -0.0 -0.3 -1.4 0.5
Severe depression (siblings) 1.6 1.7 4.2 -2.1 1.5 1.8 2.0 0.1 1.4 1.0 -0.5 -0.9 1.0 1.4 0.5
Pack years adult smoking proportion 0.9 1.4 5.2 0.6 -0.2 -0.3 -0.6 2.3 2.1 0.3 -0.8 0.7 0.9 1.2 1.7
Impedance of leg (right) 3.0 14.5 45.0 -4.5 -6.1 -2.3 -3.0 -1.2 -2.5 -6.7 -3.1 3.8 -2.6 -3.4 -2.5
Leg fat-free mass (left) 1.1 5.7 18.2 2.6 4.2 1.0 1.5 1.2 2.0 4.3 1.5 -2.2 1.4 2.2 1.9
Trunk fat percentage 0.1 0.4 1.7 0.5 -0.2 -1.3 -0.9 0.1 -0.5 -0.9 -0.5 -0.1 -0.5 -0.4 -0.3
Hand grip strength (right) 0.1 0.2 1.3 -1.2 -0.2 -0.3 0.1 -0.2 0.4 -0.3 -0.0 0.5 0.4 0.0 0.1
Townsend deprivation index at recruitment 0.6 0.8 1.6 -0.1 -0.9 1.2 -0.0 -1.3 -1.2 -1.2 -0.3 -1.2 -0.3 -0.5 -0.8
Current tobacco smoking 0.4 0.6 2.1 -0.7 -1.4 -0.9 -0.9 -0.1 0.0 -1.3 -0.5 0.8 -0.2 -0.2 0.3
Average weekly fortified wine intake 0.4 0.4 1.3 1.1 0.0 -0.9 -0.3 0.4 -0.0 0.0 0.8 1.0 0.7 0.2 0.7
Maternal smoking around birth 0.3 0.5 2.0 0.1 -1.2 -0.1 0.4 0.1 -0.4 -1.4 0.2 0.9 0.6 0.6 -0.8
Fed-up feelings 0.3 0.6 2.1 0.7 -0.5 1.4 0.9 1.2 0.5 -0.1 -0.7 -0.5 0.3 0.7 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.3 1.5 -1.1 -0.0 -0.6 -1.0 -0.6 -0.5 1.3 0.5 1.3 0.6 1.2
Relative age voice broke 1.5 2.4 5.7 0.3 -2.4 -1.4 -1.9 -0.0 -0.9 -1.8 -0.9 0.2 -2.2 -1.3 -2.2
Taking other prescription medications 0.8 1.2 5.3 0.8 -1.2 -1.9 -2.3 -0.1 -0.9 -0.4 -0.4 1.2 -0.5 -0.5 0.2
Age when periods started (menarche) 0.9 2.1 8.5 -2.9 -2.0 -0.3 -0.6 -0.3 0.2 -2.0 -2.2 1.2 -1.0 -0.1 -0.4
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.9 0.9 -0.7 0.1 -0.9 1.4 1.0 -0.1 0.8 0.0 1.0 1.1 1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.9 1.9 6.3 1.0 -0.1 0.1 0.2 -1.5 -2.3 -1.0 0.3 -1.5 -1.6 -2.5 -1.6
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.9 -0.1 -1.1 0.1 -1.1 -0.2 -0.7 -0.4 0.7 0.6 0.9 1.4 1.1
Qualifications: CSEs or equivalent 1.3 1.7 5.9 -1.1 -0.3 1.6 0.9 -0.3 0.4 -0.1 1.0 -0.3 2.2 2.4 1.9
Serious illness, injury or assault to yourself 1.4 1.7 4.3 -0.8 -1.6 -1.5 -1.9 1.1 1.1 -0.6 -2.1 2.0 -0.2 0.1 -0.5
High blood pressure 2.4 6.6 24.0 -0.5 -4.9 -2.5 -4.0 0.1 -1.2 -4.3 -2.0 0.6 -2.3 -0.7 -1.6
Hayfever, allergic rhinitis or eczema 1.4 2.9 8.3 2.9 0.2 -2.5 -1.5 1.1 1.0 0.6 1.3 2.3 1.9 1.0 2.0
Multivitamins +/- minerals 1.5 1.9 3.2 1.7 -0.5 -1.8 -1.3 1.8 1.6 0.9 -0.1 1.6 1.1 1.4 1.5
Stomach or abdominal pain in last month 0.9 1.1 3.4 -0.4 0.3 0.6 -0.2 1.8 1.2 0.6 0.1 -1.0 1.3 1.7 1.5
Supplements: Glucosamine 0.3 0.4 2.2 -0.2 0.5 1.5 1.1 -0.2 -0.4 -0.3 -0.6 -0.7 0.3 0.4 0.0
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 4.6 1.6 1.5 1.0 0.4 1.0 -0.3 2.1 0.9 -1.8 0.7 0.4 2.1
Medication: Atenolol 0.6 0.7 2.4 0.5 -0.5 -0.0 -0.6 -0.0 -0.2 -1.2 -1.5 -0.1 -1.0 -1.1 -1.3
Medication: Levothyroxine sodium 1.6 2.8 7.0 -0.5 -2.5 -2.6 -2.6 -0.6 -1.6 -1.8 0.9 2.5 0.2 -0.4 -0.1
Sitting height 0.4 2.8 11.1 0.1 3.3 0.4 0.5 0.4 0.1 2.6 2.7 -0.9 1.6 0.4 2.0
Chronic bronchitis/emphysema (father) 0.7 0.8 3.3 0.9 -0.6 1.8 1.1 1.0 0.8 -0.4 -0.6 -0.6 0.6 0.9 0.8
High blood pressure (mother) 1.5 2.1 5.3 -2.3 -2.1 -1.2 -1.7 1.4 1.4 -1.6 -1.7 0.8 -0.3 0.7 -1.0
Body mass index (BMI) 0.3 1.1 5.0 2.2 1.7 -0.5 -0.0 0.2 0.1 1.5 0.8 -1.1 0.7 0.8 0.6
Impedance of leg (left) 2.5 12.0 36.4 -4.6 -5.3 -2.0 -2.4 -1.0 -2.3 -6.0 -2.8 3.6 -2.2 -3.1 -2.6
Leg predicted mass (left) 1.1 5.9 18.8 2.6 4.2 1.0 1.5 1.2 2.0 4.3 1.6 -2.2 1.4 2.2 2.0
Trunk fat mass 0.1 0.3 1.2 1.1 0.8 -1.0 -0.6 0.5 0.1 0.2 -0.1 -0.5 -0.1 0.1 0.2
Waist circumference 0.3 1.0 3.6 0.7 -0.8 -1.6 -1.9 -0.7 -1.3 -0.9 0.5 -0.3 -0.9 -1.0 0.1
Number of incorrect matches in round 0.4 0.6 1.3 -0.7 -0.7 -0.8 -0.7 -1.0 -0.5 -0.6 1.2 0.2 1.1 0.8 0.1
Past tobacco smoking 0.8 1.5 4.9 1.1 1.4 -0.1 -0.0 1.0 1.1 1.0 1.7 0.7 1.7 0.7 2.2
Alcohol usually taken with meals 1.4 2.3 9.6 1.6 3.1 0.0 1.0 0.5 0.2 3.1 0.5 -1.1 -0.6 -1.4 -0.3
Nervous feelings 0.7 1.3 4.3 0.5 1.2 1.8 1.1 1.1 1.0 2.1 0.1 -1.1 -0.2 1.0 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 3.4 0.7 -1.3 -0.0 -0.3 -0.9 -0.7 -0.4 1.2 0.6 1.4 1.0 1.8
Hearing difficulty/problems with background noise 1.3 2.0 6.7 -1.0 1.7 0.6 0.8 -1.1 -1.1 1.3 0.0 -2.6 -1.4 -0.4 -2.6
Hair/balding pattern: Pattern 2 0.7 0.9 3.0 0.4 0.3 1.0 1.3 1.5 1.0 1.7 0.4 0.1 0.6 0.9 0.8
Had menopause 1.4 1.8 6.6 1.5 -0.2 0.3 -0.3 -1.8 -2.6 -0.4 1.9 -0.1 -0.5 -2.1 0.8
Had other major operations 2.0 2.4 6.5 1.3 1.9 0.9 1.4 -1.1 -1.7 0.6 -0.3 -1.8 -1.6 -2.6 -2.0
Forced vital capacity (FVC) 0.6 2.3 5.1 -1.7 2.0 1.9 1.8 -2.3 -1.2 0.8 0.9 -2.2 0.1 0.2 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 5.9 1.3 0.7 0.7 1.2 -1.6 -2.4 -0.5 1.0 -1.3 -1.1 -2.4 -0.6
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 3.3 1.2 0.4 0.6 0.3 -0.7 -0.0 0.6 1.4 -0.6 1.8 1.5 0.6
Qualifications: None of the above 0.2 0.4 1.3 -0.6 -0.3 -0.1 0.4 -0.1 -0.7 -1.1 -0.7 -0.3 -1.0 -0.8 -0.1
Financial difficulties in last 2 years 1.4 1.8 6.5 -1.1 -2.6 -1.2 -1.1 -0.8 -1.3 -2.5 0.0 0.9 -0.6 -1.2 -0.6
Mouth/teeth dental problems 0.2 0.2 1.8 -0.7 -0.1 -0.2 -0.5 -1.3 -0.4 -0.3 -0.0 -0.3 0.0 -0.1 0.3
Heart attack 1.9 2.5 6.3 -0.5 -1.3 -0.5 -0.0 -0.8 -1.9 -1.9 -1.8 0.7 -2.3 -2.5 -2.1
Allergy 2.0 4.6 15.2 -3.9 -0.1 3.1 2.1 -0.1 0.4 -0.7 -2.9 -2.5 -2.1 -0.3 -2.4
Pain all over the body in last month 0.8 0.9 2.2 -0.5 -1.5 -0.2 -0.9 0.2 0.4 -1.4 -0.9 1.3 1.1 1.0 0.4
Diabetes (self-reported) 1.4 2.1 8.2 0.1 -2.9 -1.5 -2.7 -0.5 -1.3 -2.0 0.2 1.1 -0.5 -0.6 0.3
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 4.1 1.7 -0.4 -0.4 -0.2 -0.6 -0.9 -0.8 2.0 0.7 0.9 -0.1 0.4
Medication: Ramipril 1.0 1.3 4.9 -1.2 -1.9 0.9 0.1 0.4 0.3 -2.2 -1.8 -0.2 -0.5 0.4 -1.1
Medication: Simvastatin 1.1 1.6 7.9 0.2 -2.8 -0.8 -2.0 -0.5 -0.8 -2.1 -0.5 0.3 -0.8 -0.6 -0.3
Fluid intelligence score 1.0 2.1 8.8 2.6 1.5 -0.8 -0.8 1.3 0.7 3.0 1.2 -1.3 -0.3 -0.0 0.8
Illnesses of siblings 0.5 0.7 2.0 -0.1 0.5 1.2 0.8 -1.4 -1.3 0.2 1.1 -0.2 0.5 -0.7 0.7
Neuroticism score 1.1 2.3 6.8 1.2 1.2 2.6 1.8 1.2 1.3 1.9 0.2 -1.6 0.9 1.8 1.1
Weight 0.3 1.5 6.5 1.7 2.5 -0.4 0.1 0.5 0.4 2.2 0.8 -1.2 0.3 0.6 0.6
Impedance of arm (right) 1.4 6.7 19.7 -3.0 -3.7 -2.1 -2.0 -1.0 -2.4 -4.4 -1.0 2.4 -2.2 -2.8 -1.8
Arm fat percentage (right) 0.1 0.4 1.7 1.1 0.4 -1.3 -0.7 0.1 -0.7 -0.2 0.4 -0.6 0.3 0.0 0.1
Trunk fat-free mass 0.6 3.5 13.7 1.9 3.6 0.5 0.8 0.4 1.0 3.7 1.5 -1.6 1.1 1.2 1.4
Hip circumference 0.4 1.6 6.9 1.5 2.6 -0.2 0.6 0.5 -0.0 2.3 0.9 -1.6 0.1 0.3 0.5
Time employed in main current job 0.2 0.2 0.8 0.1 -0.7 0.2 -0.4 0.0 0.1 -0.3 0.5 0.1 0.9 0.7 0.6
Alcohol intake versus 10 years previously 0.4 0.7 2.0 -1.4 -0.9 -0.7 -1.1 -0.4 -0.7 -0.5 0.2 -1.0 -0.7 0.0 -1.0
Father’s age at death 2.9 3.9 10.6 0.8 3.2 3.1 3.3 0.2 0.8 2.5 1.2 -0.8 1.1 0.6 2.3
Worrier / anxious feelings 0.7 1.3 3.5 1.8 0.3 1.9 1.0 0.6 0.6 0.8 0.8 -1.5 0.9 1.5 1.0
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 2.7 0.6 0.6 0.0 0.1 -1.1 -1.6 0.4 1.6 -0.5 1.6 -0.1 1.1
Falls in the last year 2.8 3.8 5.9 -1.6 -2.0 -2.4 -2.4 -2.0 -2.4 -2.4 -0.7 1.1 -1.2 -2.3 -2.0
Hair/balding pattern: Pattern 3 1.4 2.1 7.0 0.0 -1.1 -0.6 -1.1 -2.1 -2.6 -2.1 1.9 -0.2 0.5 -1.4 -0.6
Number of live births 1.5 2.1 5.3 1.8 -2.3 -1.1 -1.1 -1.3 -1.4 -1.9 1.2 1.7 0.1 -0.5 1.5
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 7.8 -2.3 0.4 0.3 -0.5 -2.8 -1.5 -0.7 1.0 -1.1 0.0 -0.2 -1.1
Pulse rate 0.1 0.2 1.0 0.4 -0.8 0.4 -0.1 0.3 0.3 -0.2 0.4 -1.0 -0.2 0.7 -0.4
Happiness 0.7 0.9 3.2 1.8 0.6 0.9 0.9 0.9 1.3 1.0 -0.1 -0.2 0.3 1.3 0.7
Noisy workplace 0.3 0.3 3.1 -0.1 -0.0 0.5 -0.0 0.5 0.1 -0.3 -0.1 -1.8 0.2 0.3 -0.5
Qualifications: A levels/AS levels or equivalent 0.7 1.5 8.6 1.3 2.1 0.5 0.3 0.8 0.1 2.9 1.0 -1.0 -0.4 0.2 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.8 0.7 0.8 -0.1 -0.1 -0.4 -0.5 0.8 1.7 0.3 0.9 0.1 1.5
Mouth/teeth dental problems: Dentures 0.7 1.2 5.2 0.2 -2.3 -0.8 -1.0 0.6 -0.6 -2.1 -0.4 0.1 -1.1 -0.9 -0.7
Asthma 0.6 1.3 6.4 2.5 0.3 -1.6 -0.9 -0.7 -1.0 0.8 1.2 0.7 0.9 0.4 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 4.7 -1.0 -1.2 -0.8 -1.1 0.3 0.7 -0.8 0.6 2.2 0.7 0.3 0.1
Medication: Cholesterol lowering 3.3 5.2 11.2 1.0 -3.3 -3.4 -2.9 -0.7 -1.7 -2.9 -0.8 2.4 -2.1 -2.5 -1.2
Depression (self-reported) 0.3 0.3 2.0 -0.1 -0.4 -0.6 0.2 0.0 0.3 -0.3 -0.7 1.4 0.4 0.1 0.6
Medication: Lansoprazole 0.6 0.7 2.4 -0.2 -1.1 -1.0 -0.3 -1.5 -0.9 -0.9 -0.1 1.5 -0.3 -0.3 0.1
Prospective memory result 0.2 0.3 1.1 -0.5 -0.4 -0.0 -0.9 -0.4 0.1 -0.6 -1.1 0.1 -0.4 -0.3 -0.3
Lung cancer (father) 1.0 1.1 3.6 0.1 -1.6 -0.4 -0.6 -1.4 -0.3 -1.2 1.0 1.9 0.2 -0.9 1.2
Illnesses of mother 1.6 1.9 4.5 2.1 1.2 0.8 1.0 1.3 1.2 1.4 1.5 0.1 1.7 1.5 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 8.2 -2.9 -0.3 -0.2 -1.3 -2.9 -1.6 -1.2 1.6 -0.4 0.5 0.2 -0.5
Pulse wave Arterial Stiffness index 0.5 0.6 2.4 1.5 0.2 -0.2 -0.4 -0.3 -0.6 -0.2 1.1 0.2 0.4 -0.7 1.4
Impedance of arm (left) 1.1 5.0 17.1 -3.0 -3.5 -1.5 -1.3 -0.6 -1.7 -4.1 -1.2 2.3 -1.5 -2.0 -1.0
Arm fat mass (right) 0.2 0.6 1.7 1.3 1.3 -1.1 -0.6 0.0 -0.4 0.8 0.7 -0.9 0.2 0.1 0.4
Trunk predicted mass 0.6 3.5 13.9 1.8 3.7 0.5 0.8 0.4 0.9 3.7 1.6 -1.5 1.2 1.2 1.6
Standing height 0.1 0.7 3.3 -1.2 1.8 -0.4 -0.2 0.4 0.6 1.5 0.1 0.1 -0.8 -0.6 -0.0
Length of working week for main job 1.0 1.1 3.6 0.9 -0.4 0.5 0.4 1.1 1.3 -0.2 -0.6 0.8 1.6 1.1 1.9
Exposure to tobacco smoke at home 0.6 0.7 3.0 0.4 -0.2 -1.7 -1.4 -0.3 -0.8 0.3 1.4 0.3 -0.2 -0.1 0.3
Breastfed as a baby 0.7 0.9 1.7 1.3 1.1 0.4 1.1 -0.1 0.4 1.3 -0.5 -1.3 -1.0 -0.7 -1.0
Tense / ‘highly strung’ 0.5 0.8 1.9 0.1 1.1 1.2 1.0 0.5 1.1 1.4 -0.2 -0.5 0.9 1.2 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 5.0 0.1 -2.2 -0.2 -0.9 0.6 0.3 -1.5 -1.4 0.7 -0.1 0.7 -1.1
Hair/balding pattern: Pattern 4 0.5 1.3 4.1 -0.2 1.9 0.5 1.6 0.1 0.9 1.4 -2.0 -1.3 -0.9 0.0 -0.1
Birth weight of first child 0.6 1.1 4.3 -1.7 0.2 -0.6 -0.8 -0.7 0.1 0.7 1.4 0.5 2.1 1.1 -0.1
Peak expiratory flow (PEF) 0.8 1.8 5.8 -2.3 -0.4 0.1 -0.7 -2.4 -1.7 -1.3 -0.1 -0.7 -0.8 -1.1 -1.7
Pulse wave reflection index 1.1 1.4 4.1 0.3 -1.6 -1.3 -1.4 -1.0 -0.7 -1.8 0.2 2.0 -0.1 -0.9 0.6
Ever highly irritable/argumentative for 2 days 0.8 1.0 3.6 0.3 -0.4 -0.7 -1.1 1.9 1.5 0.4 -0.3 0.8 1.1 1.3 0.1
Loud music exposure frequency 0.1 0.1 0.5 -0.1 0.1 -0.4 -0.3 0.3 -0.0 -0.1 -0.5 -0.0 0.1 0.7 -0.4
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 2.7 1.6 1.0 0.7 -0.2 0.7 0.9 1.6 1.2 -0.2 1.5 1.1 1.7
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.7 1.2 1.0 0.4 1.1 -1.0 -1.2 0.7 1.3 0.1 -0.3 -0.8 -0.0
Blood clot in the leg (DVT) 0.6 0.7 2.1 0.4 -1.1 -1.0 -1.0 -0.3 -1.0 -1.4 0.3 0.7 0.2 -1.4 0.1
Medication: Paracetamol 1.0 1.6 4.9 -1.3 -2.2 -1.7 -2.1 -0.1 0.0 -1.7 -0.6 1.5 0.2 0.3 -0.1
Headache pain in last month 0.6 1.1 3.3 1.6 -0.4 -1.2 -1.0 -0.0 0.5 1.1 1.8 0.5 0.4 1.2 1.2
Medication for cholesterol, blood pressure or diabetes 3.0 5.0 12.6 0.0 3.5 2.7 2.8 -0.4 0.4 3.4 2.5 -1.2 2.4 1.1 2.4
Glaucoma (self-reported) 0.9 1.1 4.4 2.1 1.2 -0.9 -0.4 0.7 0.9 1.9 0.1 -0.7 -0.0 0.7 0.1
Gout (self-reported) 0.3 0.4 2.1 0.4 0.7 0.8 1.0 0.2 -0.4 0.5 0.4 -1.4 -0.6 -0.3 -0.2
Hypothyroidism/myxoedema (self-reported) 2.5 4.8 12.7 -0.4 -3.6 -3.2 -3.1 -1.3 -2.5 -2.7 0.4 2.2 -1.3 -1.3 -1.2
Medication: Amlodipine 1.0 1.4 4.9 0.6 -2.2 -1.0 -1.6 0.9 0.4 -1.7 -1.6 0.1 -0.9 0.6 -0.7
Medication: Ventolin 100micrograms inhaler 0.8 1.0 3.1 1.1 -0.1 -1.4 -0.9 0.7 -0.5 -0.2 1.4 1.4 1.8 -0.1 0.4
Birth weight 0.4 0.8 4.1 -2.0 -0.6 0.3 -0.8 -0.8 -0.5 -1.1 0.5 0.6 0.9 -0.4 0.8
Chronic bronchitis/emphysema (mother) 1.3 1.5 4.9 -1.6 -1.6 -1.3 -1.5 -0.9 -0.8 -2.2 -1.3 0.9 -0.4 -0.3 -0.6
High blood pressure (siblings) 0.9 1.3 3.8 -0.5 -1.4 -1.8 -1.7 0.8 0.7 -1.2 -2.0 0.4 -0.7 0.4 -0.5
Forced vital capacity (FVC), Best measure 0.6 2.2 6.9 -1.9 1.7 1.4 0.9 -2.6 -1.5 0.7 1.4 -2.0 0.2 0.4 -1.1
Body fat percentage 0.1 0.3 1.3 0.7 -0.1 -1.1 -0.7 0.3 -0.5 -0.9 -0.4 -0.2 -0.2 -0.3 -0.2
Leg fat percentage (right) 0.2 0.6 2.0 0.9 -1.0 -1.0 -1.0 0.6 -0.5 -1.4 -0.7 0.1 -0.2 -0.2 -0.2
Arm fat-free mass (right) 0.9 4.6 16.0 2.2 4.0 1.0 1.2 0.5 1.5 4.0 1.3 -1.7 1.6 1.7 1.9
Exposure to tobacco smoke outside home 0.7 1.0 2.5 -1.4 1.3 -0.4 0.6 1.2 1.1 1.1 -1.6 0.0 0.2 1.1 -0.1
Comparative body size at age 10 0.5 1.4 4.6 0.7 -0.3 -0.4 -0.4 -1.9 -1.9 -1.1 1.5 0.2 -0.5 -2.2 -0.2
Number of full brothers 3.2 4.0 12.3 -0.8 -3.5 -2.7 -3.5 -0.3 -0.1 -2.6 -0.2 2.8 -0.4 -0.4 0.9
Worry too long after embarrassment 0.6 1.0 4.5 0.9 -0.1 1.7 0.6 0.2 0.4 0.9 -0.5 -2.1 -1.3 0.9 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 5.7 -1.0 -2.4 -0.7 -0.5 -0.2 -0.4 -2.0 -0.6 1.6 -0.1 0.0 -1.0
Wheeze or whistling in the chest in last year 0.5 0.9 2.5 1.6 -1.5 -0.3 -0.3 0.8 0.4 -0.4 0.9 0.7 1.5 1.1 0.7
Number of children fathered 0.3 0.4 1.3 -0.7 -0.3 0.5 0.4 1.2 -0.4 -0.4 -0.6 -0.6 -0.4 -0.0 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.8 6.1 -1.1 1.2 2.3 2.5 -0.5 0.0 1.4 1.0 -1.3 1.1 1.4 0.2
Age at first live birth 1.0 1.7 5.6 1.2 2.1 0.6 0.9 1.2 0.7 2.4 0.5 -1.6 0.2 1.0 -1.4
Pulse wave peak to peak time 0.6 0.6 1.7 -1.3 0.2 0.4 0.7 0.6 0.9 0.6 -1.1 -0.3 -0.2 0.9 -1.2
Health satisfaction 1.3 1.7 5.4 1.3 -0.3 -0.2 -0.7 2.2 1.6 0.6 0.2 0.2 1.8 2.3 1.1
Shortness of breath walking on level ground 1.1 1.3 2.9 -1.7 -1.1 -1.7 -1.6 0.1 0.0 -1.1 -0.3 1.7 1.3 0.5 0.7
Qualifications: College or University degree 0.2 0.5 1.8 0.7 0.9 -0.2 0.4 -1.3 -0.5 1.1 0.8 -0.1 0.2 -0.2 -0.6
Eye problems/disorders: None of the above 0.3 0.3 0.9 -0.0 0.2 0.4 0.5 0.7 0.5 0.3 1.0 -0.2 0.5 0.8 0.8
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.9 -0.9 0.3 0.8 0.1 -0.9 -0.7 0.0 0.3 -0.5 0.1 -0.8 0.7
Emphysema/chronic bronchitis 1.3 1.5 4.0 2.0 -0.1 -1.5 -1.6 -0.5 -1.4 0.3 1.3 1.0 0.4 -1.4 1.6
Medication for pain relief, constipation, heartburn 2.0 3.3 10.2 -0.1 2.8 2.7 2.9 0.1 -0.7 2.3 0.6 -3.2 0.1 0.1 0.2
Neck or shoulder pain in last month 0.3 0.4 2.3 1.5 -0.7 -0.3 0.1 -0.3 -0.2 -0.3 1.1 0.5 -0.0 -0.2 0.1
Medication: Blood pressure 1.8 3.2 10.3 -0.7 -2.0 -0.8 -1.3 1.8 1.3 -2.1 -3.2 -0.5 -1.7 0.5 -2.9
Angina (self-reported) 2.0 2.7 7.3 2.1 -1.4 0.6 0.6 -0.8 -0.2 -1.8 -1.6 0.8 -2.7 -2.3 -2.3
Migraine (self-reported) 0.6 0.7 3.5 -0.2 0.2 -0.1 -0.1 0.8 1.0 0.4 0.3 0.3 1.9 1.4 1.0
Medication: Ibuprofen 1.2 1.4 7.3 -1.6 -1.5 -0.9 -1.3 -0.1 0.4 -1.4 0.3 2.7 0.0 -0.5 -0.3
Medication: Allopurinol 0.1 0.2 0.4 0.6 -0.1 0.5 0.5 0.4 -0.2 -0.2 0.3 -0.3 -0.0 -0.5 0.5
Medication: Omeprazole 0.5 0.6 2.8 -0.9 -1.7 -0.0 -0.6 -0.7 -0.1 -1.2 -1.0 0.5 -0.6 0.2 0.1
Medication: Seretide 50 evohaler 0.7 0.8 3.1 1.8 0.9 -1.4 -1.3 0.1 0.2 1.1 -0.1 0.1 0.1 0.9 -0.7
Mean time to correctly identify matches 1.2 2.2 9.9 0.7 -3.1 -0.8 -1.2 1.2 1.1 -2.2 -0.5 1.6 0.8 1.6 0.7
Heart disease (mother) 2.0 2.4 7.5 -1.9 -0.6 -0.4 -0.1 -0.4 -0.5 -0.6 -2.7 -0.1 -2.7 -1.8 -2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 3.6 -0.1 -1.1 0.1 -0.3 -0.7 -1.5 -0.9 0.2 -0.4 -1.9 -1.9 -0.9
Whole body fat mass 0.1 0.3 1.4 1.2 0.8 -0.9 -0.5 0.6 0.1 0.2 0.2 -0.5 0.2 0.2 0.5
Leg fat mass (right) 0.1 0.4 1.8 1.3 0.7 -0.7 -0.6 0.8 0.2 0.3 0.1 -0.4 0.4 0.4 0.5
Arm predicted mass (right) 0.8 4.3 15.7 2.0 4.0 1.1 1.3 0.7 1.6 3.9 1.1 -1.7 1.4 1.6 1.6
Pulse rate, automated reading 0.6 2.0 6.5 0.1 -0.7 0.7 0.5 2.4 2.5 0.6 -1.6 -1.1 0.5 2.5 -0.6
Alcohol intake frequency. 0.7 1.7 5.7 -0.3 -1.9 -2.4 -2.4 -1.0 -0.7 -1.2 -0.0 1.2 -0.6 -0.9 0.3
Comparative height size at age 10 0.1 0.7 1.4 -1.2 0.2 -0.8 -1.1 0.9 1.2 -0.4 0.1 0.9 0.4 0.5 1.0
Number of full sisters 0.5 0.6 2.8 -0.4 -1.7 0.2 -0.4 -0.0 -0.7 -1.0 0.5 0.1 -0.4 -0.5 1.2
Suffer from ‘nerves’ 0.7 1.0 3.4 0.6 0.7 1.9 1.3 0.8 0.6 0.9 0.7 -0.7 1.0 1.1 1.1
Overall health rating 0.3 0.6 3.7 0.9 -1.3 -0.7 -1.9 0.3 -0.4 -0.5 0.4 -0.0 0.2 0.3 0.1
Chest pain or discomfort 0.6 0.8 1.8 -1.0 -1.0 -1.0 -1.0 -0.4 -0.9 -0.4 -0.7 0.2 -1.3 -1.2 -1.1
Had major operations 0.6 0.7 3.2 0.7 -0.3 -1.4 -1.8 -0.6 -0.4 0.1 0.0 0.9 -0.5 -0.6 -1.1
Age at last live birth 1.7 2.5 4.7 1.4 2.1 1.0 1.6 2.1 1.8 2.2 -0.3 -1.6 0.5 1.4 -1.6
Family relationship satisfaction 0.3 0.3 1.0 0.1 -0.3 0.3 0.3 -0.1 0.2 -0.8 0.6 0.8 0.9 0.4 1.0
Leg pain on walking 2.2 2.7 9.1 0.1 -2.1 -2.7 -3.0 -0.5 -1.0 -2.2 -0.3 1.5 0.5 -0.5 -1.8
Qualifications: NVQ or HND or HNC or equivalent 1.8 2.2 8.0 -0.0 -2.8 -1.2 -1.8 0.2 -0.2 -2.4 0.8 1.3 1.8 1.1 0.9
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.7 -0.2 -0.7 0.1 -0.2 0.6 -0.0 -0.1 -0.8 -0.8 -0.2 0.6 -0.3
Illness, injury, bereavement, stress in last 2 years 0.7 0.8 3.0 0.5 1.7 1.0 0.4 1.0 0.8 1.4 -0.2 -1.1 0.6 0.6 0.1
Medication: Aspirin 2.0 2.7 6.8 1.2 -1.9 -1.2 -1.6 1.3 1.2 -1.7 -2.6 1.2 -1.9 -0.6 -2.2
Supplements: Vitamin C 0.7 0.8 2.3 0.3 1.0 -0.1 -0.3 0.8 1.4 1.5 -0.0 -0.6 0.3 1.5 0.7
Knee pain experienced in last month 0.4 0.6 3.1 0.4 -1.8 0.4 -0.2 0.7 0.5 -0.7 0.8 0.7 0.5 1.0 -0.3
Hypertension (Self-reported) 2.1 5.8 20.8 -0.5 -4.6 -2.2 -3.8 -0.0 -1.3 -4.2 -1.8 0.3 -1.9 -0.6 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.3 -0.8 -1.1 -0.5 -0.7 -0.6 -0.2 -0.3 -0.0 0.2 -0.4 0.2 -0.4
Illnesses of father: Heart disease 0.4 0.6 2.4 -0.2 -0.7 -1.6 -0.6 -0.0 -0.4 -0.5 -0.8 0.9 -0.9 -0.8 -0.3
Illnesses of siblings: Diabetes 0.7 0.9 3.4 1.2 -1.3 -1.8 -1.2 0.5 0.7 -1.1 0.5 0.3 -0.5 0.1 -0.4
Smoking status: Previous 1.0 1.5 6.0 -0.7 -1.6 -0.1 -0.0 -0.4 -0.7 -1.2 -1.7 -0.3 -1.9 -0.7 -2.4
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 3.5 -1.9 0.7 -1.1 -0.3 -0.4 -0.2 0.2 0.1 1.5 -0.2 -0.5 -0.8
Whole body fat-free mass 0.9 4.9 18.1 2.3 4.2 0.8 1.2 0.7 1.5 4.3 1.6 -1.9 1.3 1.7 1.6
Leg fat-free mass (right) 1.3 6.9 23.5 2.6 4.8 1.2 1.8 1.2 2.0 4.8 1.9 -2.4 1.6 2.3 1.8
Arm fat percentage (left) 0.1 0.3 1.3 1.1 0.5 -0.8 -0.3 0.3 -0.3 -0.1 0.3 -0.8 0.6 0.5 0.4
Average weekly red wine intake 0.7 1.1 5.1 0.6 1.7 0.4 1.5 1.0 0.7 2.2 0.2 -0.2 0.6 0.4 -0.3
Handedness (chirality/laterality): Left-handed 0.9 1.0 2.7 0.5 1.6 1.0 0.8 0.7 1.0 1.6 0.8 0.5 1.2 0.8 1.1
Mood swings 0.3 0.5 1.4 1.0 0.2 1.1 0.9 -0.1 -0.2 0.5 0.5 -0.2 1.0 0.6 1.2
Loneliness, isolation 0.5 0.8 2.9 1.7 0.2 0.9 0.9 0.2 0.8 0.7 -0.0 -1.2 0.5 1.3 0.2
Long-standing illness, disability or infirmity 0.4 0.7 2.7 -0.4 -0.7 0.4 -0.8 -0.6 -1.1 -0.4 -0.7 -1.6 -0.8 0.4 -0.9
Ever had bowel cancer screening 0.4 0.5 2.2 1.3 -0.3 0.3 -0.5 0.6 0.0 0.4 0.5 0.4 0.7 0.1 1.5
Diabetes diagnosed by doctor 2.6 4.2 15.4 -0.0 -3.9 -2.4 -3.3 -1.1 -1.9 -3.0 0.6 1.8 -0.7 -1.1 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 2.2 2.4 9.9 1.3 0.7 0.9 -0.6 1.0 1.9 2.0 -0.1 -2.3 0.7 3.2 1.0
Friendships satisfaction 1.2 1.5 5.4 0.4 -0.2 0.5 0.3 -0.4 0.1 0.2 1.4 1.1 2.3 1.7 2.3
Qualifications: nursing, teaching 0.4 0.7 3.4 0.6 1.0 -0.8 -1.1 -1.0 0.1 1.8 0.8 0.1 -0.4 0.2 0.1
Commuting to job workplace: Walk 0.6 0.7 1.9 0.0 1.3 1.4 1.2 -1.2 -0.5 0.6 0.5 -0.5 0.1 -0.5 -0.5
Eye problems/disorders: Cataract 1.1 1.3 3.9 0.7 0.8 1.4 1.2 -2.0 -1.8 0.3 -0.2 -0.6 -0.9 -1.6 0.4
Mouth/teeth dental problems: Mouth ulcers 1.3 2.1 7.2 1.1 1.1 0.9 1.0 2.7 1.9 1.8 0.5 -0.3 1.5 2.2 0.2
Medication for cholesterol 0.3 0.4 1.1 0.0 1.0 -0.2 0.9 -0.4 -0.3 0.8 1.0 0.6 0.5 -0.4 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 6.9 0.4 -2.0 -2.6 -2.3 -0.3 -0.2 -1.4 0.3 2.3 -0.3 -0.6 0.5
Back pain experienced in last month 1.6 2.3 5.0 0.2 1.8 1.9 2.0 1.5 2.2 1.4 0.2 -1.4 1.1 1.9 0.2
Mineral and other dietary supplements 0.7 1.0 4.1 -0.0 1.0 2.0 1.8 0.1 -0.0 0.9 0.3 -1.4 -0.5 -0.3 -0.3
Breast cancer (self-reported) 1.8 2.1 10.5 0.0 0.8 -0.7 0.4 -1.8 -1.9 -0.3 -0.8 -0.3 -2.4 -3.2 -0.6
Asthma (self-reported) 0.7 1.3 6.9 2.6 0.4 -1.4 -0.8 -0.5 -0.8 1.2 1.3 0.5 1.1 0.6 0.8
Osteoporosis (self-reported) 0.8 1.0 3.2 0.6 1.7 0.3 0.4 0.1 0.3 1.8 1.2 -1.5 0.5 0.9 -0.0
Osteoarthritis (self-reported) 0.3 0.4 1.8 1.0 -0.0 -0.4 -0.1 0.1 0.3 0.0 -0.1 1.3 0.7 0.3 0.8
Medication: Aspirin 2.3 3.0 7.1 1.1 -2.3 -1.0 -1.7 1.6 1.2 -1.8 -2.7 1.5 -2.0 -0.6 -2.1
Medication: Gliclazide 5.9 6.6 22.1 -0.1 -4.4 -2.4 -3.0 -0.8 -2.3 -4.7 1.2 3.3 1.4 -1.5 0.8
Illnesses of father: None of the above (group 1) 0.4 0.5 2.3 -1.5 -0.3 0.1 0.1 -0.2 0.6 0.0 -1.1 0.8 -0.2 0.1 -1.1
Smoking status: Current 0.4 0.7 2.1 -0.8 -1.5 -0.9 -1.1 -0.4 -0.3 -1.3 -0.2 0.8 0.2 0.0 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 2.0 6.4 -1.7 -0.7 -0.1 -0.6 -2.5 -2.1 -2.1 1.7 -0.1 1.2 -0.4 0.2
Whole body water mass 0.9 5.1 18.7 2.3 4.3 0.9 1.4 0.6 1.4 4.3 1.6 -2.1 1.2 1.7 1.6
Leg predicted mass (right) 1.3 6.9 23.7 2.6 4.8 1.1 1.7 1.1 2.0 4.9 1.9 -2.4 1.6 2.3 1.8
Arm fat mass (left) 0.2 0.7 2.4 1.5 1.6 -0.7 -0.2 0.2 -0.2 1.1 0.7 -1.1 0.4 0.4 0.6
Number of self-reported non-cancer illnesses 1.2 2.1 7.9 0.2 -2.8 -1.0 -2.1 -0.7 -1.8 -2.2 -0.5 0.2 -1.1 -0.9 -0.7
Average weekly champagne plus white wine intake 0.8 1.1 3.9 0.8 1.4 2.0 2.0 -0.0 -0.4 0.4 1.0 -0.6 0.8 -0.4 0.3
Miserableness 1.0 1.7 6.1 0.5 0.4 1.6 1.4 1.0 1.2 1.0 -0.1 -0.3 2.0 2.5 1.3
Guilty feelings 0.7 1.0 3.5 0.4 -1.5 -1.9 -1.5 0.8 -0.2 -0.1 -0.2 1.1 -0.9 -0.4 -0.8
Wears glasses or contact lenses 0.3 0.4 1.4 -0.9 0.5 -0.4 0.8 0.4 0.0 -0.6 -0.0 0.4 1.2 -0.3 -0.7
Ever taken oral contraceptive pill 1.0 1.1 4.7 -0.5 -0.5 -0.7 -0.3 -1.9 -0.7 0.0 -0.1 -0.9 -1.5 -0.5 -2.2
Hearing aid user 0.5 0.6 2.1 0.9 -0.8 -0.5 -0.4 -0.3 -0.8 -0.6 1.5 0.6 1.1 -0.3 0.6
Mother’s age at death 1.6 1.9 7.2 1.9 2.5 0.4 1.3 1.0 1.4 2.7 0.5 -1.2 -0.1 0.3 0.0
Financial situation satisfaction 1.2 1.5 5.3 0.4 -0.9 0.6 -0.1 0.6 0.5 -0.7 0.8 2.1 2.3 1.0 2.0
Tinnitus: Yes, now most or all of the time 0.6 0.7 3.1 0.7 -0.4 -0.8 -0.5 -1.0 -1.8 -0.3 1.1 -0.2 -0.1 -0.7 -0.7
Commuting to job workplace: Public transport 0.4 0.4 1.8 0.2 -0.0 0.5 0.1 -1.3 -1.1 -0.6 0.7 0.2 -0.3 -0.9 -0.4
Eye problems/disorders: Glaucoma 0.4 0.5 1.7 1.0 0.0 -1.3 -1.1 0.6 1.0 0.5 -0.3 -0.1 0.2 0.6 -0.4
Medication: Blood pressure 0.7 1.3 4.1 -0.2 -1.9 -0.7 -2.0 -0.8 -1.1 -1.9 -0.2 -0.2 -1.0 -0.9 -0.7
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.2 0.6 -0.5 1.1 0.2 0.3 0.2 -0.1 -0.1 -0.3 0.9 0.7 -0.1
Supplements: Fish oil (including cod liver oil) 0.4 0.6 2.0 -0.3 -0.3 -1.3 -1.3 0.3 0.3 -0.1 -0.7 1.4 0.1 -0.0 0.4
High cholesterol (Self-reported) 1.7 3.1 10.6 0.0 -3.2 -1.6 -2.1 0.1 -0.9 -2.7 -0.9 2.1 -1.7 -1.7 -0.0
Medication: Bendroflumethiazide 0.8 1.1 4.2 -0.2 -1.1 -1.3 -2.1 -0.6 -1.0 -1.1 0.1 -1.3 -0.6 -0.5 -1.4
Medication: Paracetamol 1.4 2.1 4.8 -1.7 -2.2 -1.9 -2.2 -0.6 -0.7 -2.0 -0.1 2.0 -0.1 -0.8 -0.3
Medication: Lisinopril 0.6 0.8 1.8 0.9 -1.0 -0.1 -1.3 -1.1 -1.2 -1.4 1.1 -0.5 0.0 -0.5 -0.1
Medication: Atorvastatin 1.2 1.4 3.5 1.4 -1.2 -1.8 -1.2 0.0 -0.5 -0.6 -0.4 1.9 -1.7 -1.5 -0.4
Illnesses of father: High blood pressure 0.7 0.9 3.0 -0.4 0.5 -0.2 -1.0 1.3 1.4 0.3 -0.7 -1.0 0.9 1.7 0.5
Alcohol drinker status: Never 1.6 1.9 5.0 -1.2 -2.0 -1.8 -2.0 -0.9 0.1 -1.8 0.1 2.2 0.3 -0.8 0.7
Ever smoked 0.6 1.1 2.2 -1.2 -0.2 1.3 1.5 -1.2 -1.0 -0.1 -1.1 -1.5 -0.5 -0.0 -1.2
Basal metabolic rate 0.8 4.2 15.6 2.1 4.0 0.7 1.1 0.7 1.3 3.9 1.3 -1.9 1.0 1.5 1.4
Leg fat percentage (left) 0.1 0.3 0.8 0.9 -0.4 -0.8 -0.6 0.7 -0.2 -0.9 -0.5 -0.2 0.1 0.1 -0.4
Arm fat-free mass (left) 0.7 3.4 14.3 1.7 3.8 0.6 1.0 0.4 1.0 3.7 1.2 -1.7 0.9 1.1 1.2
Number of operations (self-reported) 0.6 0.9 2.6 0.3 -1.3 -0.7 -0.6 -0.4 -0.9 -1.4 -1.0 1.0 -0.1 -0.8 -1.6
Average weekly beer plus cider intake 0.4 0.5 1.8 -0.6 -1.3 -0.4 -0.2 -0.5 -1.2 -1.2 0.4 0.8 0.0 -0.2 0.4
Irritability 0.4 0.6 2.3 -0.8 1.5 0.8 0.5 0.5 0.5 1.2 -0.1 -0.2 1.0 0.7 0.2
Risk taking 0.1 0.2 0.6 -0.8 -0.3 -0.5 -0.2 0.1 0.4 0.4 0.1 0.6 0.2 0.0 -0.7
Ever had prostate specific antigen (PSA) test 2.2 2.5 8.7 -1.5 -2.5 -1.8 -2.0 1.1 0.7 -1.5 -0.8 2.9 -0.2 0.5 0.7
Fractured/broken bones in last 5 years 1.7 2.2 7.3 -1.9 -1.2 -2.1 -2.0 0.7 1.0 -0.9 -1.6 2.7 -0.3 -0.1 0.9
Age started oral contraceptive pill 0.5 0.6 3.3 1.8 0.8 0.1 0.1 1.2 0.8 0.7 -0.3 -0.2 -0.4 -0.6 0.7
Diastolic blood pressure, automated reading 3.0 9.3 29.8 -0.8 -5.3 -4.2 -5.5 -0.3 -2.2 -4.5 0.4 2.7 -0.7 -1.3 0.4
Ever depressed for a whole week 0.3 0.4 2.1 0.9 0.1 0.3 0.1 -0.1 0.8 0.2 -0.2 -0.1 0.9 1.5 -0.4
Unable to work because of sickness or disability 1.0 1.3 4.2 -1.0 -1.9 0.6 -0.1 0.5 0.6 -2.0 -0.7 1.2 1.4 1.1 0.0
Commuting to job workplace: Cycle 0.7 0.8 3.6 -0.3 1.6 1.1 1.2 -0.7 0.2 1.9 -0.3 -0.5 -0.2 -0.3 -0.0
Myopia 0.6 0.8 3.5 0.3 -0.3 -0.1 -0.5 1.7 1.0 0.2 0.5 -0.1 0.8 1.1 1.9
Vascular/heart problems diagnosed by doctor 2.5 6.9 20.5 0.7 4.5 2.4 3.8 0.4 1.7 4.3 2.4 -0.3 2.8 1.5 2.2
Cholesterol lowering medication 0.2 0.3 0.9 0.8 -0.7 0.6 -0.5 1.0 0.5 -0.1 -0.8 -0.3 -0.2 0.1 0.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 2.6 -0.1 -1.6 -0.2 -0.6 -0.7 -0.3 -0.9 -0.0 0.7 -0.1 0.5 0.5
Pain experienced in last month 0.5 0.8 3.7 0.1 0.4 -0.5 0.3 -1.1 -1.6 0.0 0.5 0.1 -1.1 -1.9 -0.4
Supplements: Calcium 0.9 1.0 4.2 -2.1 -0.6 -0.8 -0.7 0.6 1.1 -0.1 -1.7 0.4 -0.8 0.6 -0.8
Basal cell carcinoma (self-reported) 1.5 1.8 8.7 0.5 -1.0 -1.7 -1.1 -0.8 -0.7 -1.0 -0.9 -0.2 -1.8 -1.3 -3.0
Heart attack/myocardial infarction (self-reported) 2.2 2.8 6.4 -0.8 -1.2 -0.4 0.2 -0.9 -1.9 -2.1 -2.1 0.6 -2.2 -2.5 -2.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.7 0.6 -1.0 -1.0 -1.0 -0.2 -0.9 -1.3 0.1 0.5 -0.1 -1.6 -0.3
Heart disease (siblings) 0.5 0.6 1.7 -0.8 0.4 0.8 1.3 0.5 0.0 0.3 -0.6 -1.0 -1.0 -0.2 -1.2
Alcohol drinker status: Previous 0.5 0.5 1.2 -1.1 -0.8 0.0 -0.1 -1.0 -0.8 -0.8 -0.5 0.5 -0.9 -0.9 -0.4
Pack years of smoking 0.9 1.4 5.6 1.0 -0.2 -0.4 -0.8 2.4 2.1 0.3 -0.8 0.7 0.5 0.9 1.5
Impedance of whole body 1.8 9.2 29.7 -4.0 -4.7 -1.8 -1.9 -1.0 -2.2 -5.5 -2.0 3.1 -2.0 -2.8 -2.0
Leg fat mass (left) 0.1 0.4 1.7 1.3 1.0 -0.6 -0.3 0.9 0.4 0.5 0.1 -0.6 0.5 0.5 0.3
Arm predicted mass (left) 0.7 3.4 13.0 2.0 3.6 0.7 1.0 0.4 1.2 3.6 1.2 -1.6 1.0 1.2 1.2