Hub : Genes

LINGO1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0450 0.0170 1.4e-04 0.043 0.022 0.038 0.022 0.039 5.6e-06 8.6e-04 1.7e-05 0.00092 1.3e-05
2 GTEx Artery Tibial 0.0809 0.0384 3.6e-03 0.041 NA 0.021 NA 0.028 3.4e-04 NA 8.7e-03 NA 2.7e-03
3 GTEx Brain Cerebellar Hemisphere 0.4440 0.1110 7.5e-04 0.109 NA 0.156 NA 0.237 9.8e-04 NA 8.2e-05 NA 9.2e-07
4 GTEx Brain Cerebellum 0.2990 0.0920 1.1e-03 0.061 NA 0.155 NA 0.176 7.3e-03 NA 2.5e-05 NA 6.7e-06
5 GTEx Brain Hypothalamus 0.1820 0.0680 1.9e-03 0.052 NA 0.075 NA 0.075 2.4e-02 NA 7.9e-03 NA 8.1e-03
6 GTEx Lung 0.1039 0.0376 2.0e-04 0.091 NA 0.047 NA 0.076 1.9e-07 NA 1.6e-04 NA 2.0e-06
7 GTEx Skin Sun Exposed Lower leg 0.0700 0.0340 4.6e-03 0.047 NA 0.072 NA 0.085 8.4e-05 NA 1.3e-06 NA 1.5e-07
8 GTEx Testis 0.2040 0.0860 8.1e-03 0.118 NA 0.061 NA 0.086 6.5e-06 NA 1.1e-03 NA 1.1e-04
9 TCGA Breast Invasive Carcinoma 0.0388 0.0148 4.1e-08 0.029 0.031 0.030 NA 0.026 9.5e-07 4.8e-07 8.0e-07 NA 4.0e-06
10 TCGA Kidney Renal Papillary Cell Carcinoma 0.0550 0.0300 7.9e-03 0.077 0.044 0.064 NA 0.067 3.3e-05 1.6e-03 1.6e-04 NA 1.1e-04
11 TCGA Pancreatic Adenocarcinoma 0.1760 0.0770 3.2e-04 0.018 0.040 0.048 NA 0.059 5.6e-02 8.4e-03 4.2e-03 NA 1.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 3.0 4.7 15.6 -4.0 0.5 0.8 0.6 -2.2 -3.1 -1.1 0.0 -2.1 -3.7 -1.1
Bipolar Disorder or Schizophrenia 1.4 3.5 10.3 -3.1 0.7 -1.2 -0.7 -1.6 -2.3 -0.3 1.6 -2.3 -3.2 0.4
Depressed Affect (Nagel 2018) 1.4 2.9 26.2 0.2 0.7 -0.3 -1.7 -0.6 -0.6 -0.0 5.1 -0.4 -0.4 0.9
Depression (Nagel 2018) 0.7 1.1 10.7 -0.1 -0.5 0.2 -0.4 0.3 -0.1 0.2 3.3 -0.4 -0.4 -0.2
Intelligence (Savage-Jansen 2018) 0.6 1.8 4.9 -0.6 2.2 -0.7 -0.8 -1.2 -0.3 2.1 -0.1 -1.9 -0.7 1.6
Neuroticism (Nagel 2018) 1.4 3.2 30.7 1.1 -0.0 1.1 -0.7 0.4 0.2 -0.3 5.5 0.5 0.9 0.7
Schizophrenia (2018) 0.8 1.6 5.0 -0.8 0.5 -2.2 -1.4 -0.2 -0.5 0.5 2.1 -1.3 -1.1 1.4
Schizophrenia vs Biploar Disorder 1.8 2.3 5.7 1.9 1.4 -1.6 -1.0 0.2 1.3 1.8 1.4 -0.9 1.7 2.4
Worry (Nagel 2018) 1.0 2.2 12.9 1.6 -0.6 1.1 0.2 1.4 1.3 0.3 3.6 0.7 1.5 0.6
Alzheimer’s Disease (in mother) 0.8 0.9 2.3 -0.8 0.7 -1.0 -1.4 -1.5 -0.3 0.5 -0.4 -0.8 -0.9 -1.3
Alzheimer’s Disease (in father) 1.3 1.4 3.7 -1.3 0.9 0.2 0.6 -1.6 -1.9 0.1 -1.5 -0.8 -1.7 0.2
Alzheimer’s Disease (including proxy) 0.4 0.6 1.9 -0.9 0.5 -0.1 0.3 -1.1 -0.8 -0.0 -0.9 -0.5 -1.0 -1.4
Crohns Disease (2017) 2.0 4.4 14.0 1.0 -3.3 -0.2 -0.5 3.7 1.5 -3.0 1.2 3.0 0.7 0.0
Irritable Bowel Disease (IBD) 1.7 4.0 8.7 0.9 -2.9 -0.1 -0.9 2.8 1.6 -2.7 2.7 2.9 0.5 0.2
Ulcerative Colitis (UC) 1.1 2.0 7.2 0.3 -2.0 0.1 -0.7 1.0 0.8 -2.1 2.7 2.1 0.1 0.0
Major Depression (MDD) 0.7 0.9 5.1 0.4 -0.4 -0.7 -1.1 1.0 0.4 -0.5 2.3 0.6 0.5 0.5
Reaction Time 0.4 0.8 2.7 0.2 1.1 -1.5 -1.6 -0.7 -0.3 0.4 1.2 0.3 0.1 0.3
Verbal and Numeric Reasoning (VNR) 1.0 2.5 5.0 -1.7 2.1 0.2 0.7 -1.6 -1.0 2.1 -1.8 -2.2 -1.7 0.7
Breast Cancer 0.5 1.3 3.6 -1.3 -1.0 0.3 -0.2 -0.3 -0.8 -1.6 1.9 0.3 -1.4 -1.5
Ovarian Cancer 0.5 0.6 2.8 -0.8 0.5 0.4 -0.4 -0.6 -0.4 -0.2 0.8 -0.3 -1.4 1.7
Prostate Cancer 1.7 2.4 5.3 -0.1 2.3 1.6 2.1 -1.1 -0.6 1.6 -1.3 -1.5 0.5 -2.3
Age at First Birth 0.3 0.5 2.3 -0.3 -0.7 0.3 -0.3 -0.6 -0.6 -1.5 0.5 0.4 0.3 -1.1
Bipolar Disorder (2011) 1.8 1.8 5.1 -2.1 0.7 0.0 0.5 -1.7 -2.3 -0.8 -0.6 -0.9 -2.1 0.3
Body Mass Index (BMI) (2010) 1.3 1.8 5.3 0.6 1.3 -2.3 -1.5 0.3 1.7 1.2 -1.7 -0.6 -0.1 1.6
Coronary Artery Disease (CAD) 1.2 1.4 3.7 -1.0 1.9 -0.3 -1.0 -1.8 -1.0 0.4 1.5 -1.2 -1.3 -0.5
Crohns Disease (2012) 1.4 2.3 5.4 0.7 -2.0 -1.0 -1.1 2.3 1.2 -2.3 1.0 2.1 -0.1 0.7
Mean Putamen Volume 0.4 0.5 1.3 0.6 0.4 -0.5 0.5 -0.2 -0.1 -1.1 0.5 1.1 0.7 0.9
Fasting Glucose 1.7 2.1 8.4 1.4 0.7 -1.4 -0.5 1.1 2.9 1.7 -0.4 0.3 2.2 0.6
HbA1C 2.1 2.3 8.1 -0.3 2.8 0.0 -0.3 -2.0 0.7 2.2 -1.6 -2.0 -1.0 0.6
HDL Cholesterol 0.3 0.5 1.4 -0.3 -1.2 0.8 0.7 0.8 -0.2 -0.9 -0.2 0.4 -0.0 -1.1
LDL Cholesterol 0.1 0.2 0.9 0.0 0.5 -0.8 -0.9 -0.1 0.0 -0.1 0.3 0.4 0.0 0.5
Lupus 1.5 2.3 9.4 0.8 -3.1 0.0 -0.1 2.6 1.4 -1.1 1.7 1.4 0.6 0.2
Neuroticism (2016) 1.3 1.9 15.1 0.9 0.7 -0.9 -1.7 0.2 0.6 -0.1 3.9 -0.2 0.4 0.4
Primary Biliary Cirrhosis 0.6 0.9 4.4 0.6 -2.1 -0.1 0.1 1.4 0.7 -0.8 0.7 1.1 0.7 0.1
Rheumatoid Arthritis 1.8 2.4 8.4 1.1 -2.6 0.0 -0.6 2.9 2.2 -0.5 1.3 1.1 1.4 0.1
Schizophrenia (2014) 1.1 2.4 7.4 -1.1 1.2 -2.1 -1.3 -0.9 -1.2 1.3 0.8 -2.0 -1.4 2.7
Triglycerides 0.4 0.7 2.4 -0.6 1.0 -1.1 -1.5 -1.0 -1.0 0.3 0.3 -0.6 -0.5 -0.5
Type 2 Diabetes (T2D) (2012) 2.3 2.7 6.9 2.2 1.6 0.3 0.6 0.6 1.8 2.6 -1.4 -0.1 2.5 1.7
Ulcerative Colitis 1.3 1.9 7.1 0.4 -1.6 -0.7 -1.4 0.8 0.7 -2.0 2.7 1.8 -0.1 -0.4
Blood Eosinophil Count 0.4 2.8 10.7 1.9 3.3 -1.3 -0.9 -0.6 0.8 2.3 -1.4 -0.4 1.9 1.3
Blood Platelet Count 0.4 4.7 22.6 0.2 2.4 -3.4 -4.8 -1.9 0.1 1.7 1.2 -0.9 0.6 1.5
Blood Red Count 1.4 13.2 38.6 1.1 6.2 -4.9 -4.2 -2.4 1.1 4.8 -2.2 -2.9 0.8 4.3
Blood White Count 1.3 9.5 29.7 0.3 5.5 -3.8 -4.2 -3.4 -0.6 4.3 -2.3 -2.5 0.5 0.9
Heel T-Score 1.0 8.3 21.6 3.2 -4.7 -0.1 -0.9 4.2 2.4 -2.0 1.4 4.2 3.5 0.1
BMI 0.8 4.7 20.9 1.7 2.9 -1.5 -2.0 0.0 1.0 4.6 -2.6 -1.2 2.0 0.8
Height 1.4 26.4 118.8 0.5 -10.9 1.4 1.5 8.5 1.4 -7.0 3.3 5.6 0.3 -1.9
Waist Hip Ratio (WHR) 0.7 3.0 9.4 -0.3 1.8 -1.5 -1.3 -1.2 -0.5 3.0 1.2 -1.9 -0.5 3.1
Systolic Blood Pressure 0.4 2.0 7.6 -0.6 2.2 0.6 0.7 -0.7 -0.7 1.7 -2.8 -2.1 -0.1 -0.1
Smoking Status 2.2 5.3 12.5 -1.2 2.6 -3.5 -3.5 -2.6 -1.7 2.3 0.3 -2.7 -1.5 -0.5
Allergy or Eczema 0.8 2.2 9.3 -1.6 -0.8 -0.6 -0.4 -0.9 -1.6 -2.6 0.7 -0.1 -1.1 -3.0
Cardiovascular Disease 1.2 4.1 19.5 0.0 4.4 -0.5 -0.6 -2.0 -1.0 3.4 -0.0 -2.6 0.1 1.3
Hypothyroidism (self reported) 0.2 0.5 1.3 0.7 -0.9 -0.2 0.0 0.6 0.5 -0.2 0.9 1.1 0.8 -0.8
Respiratory disease 0.6 1.3 5.1 0.4 -0.8 -2.3 -2.0 1.2 0.6 -0.3 1.1 0.8 0.4 0.5
Type 2 Diabetes (T2D) (2018) 3.5 6.5 17.5 3.9 2.6 0.0 -0.9 1.8 3.8 3.6 0.1 0.3 4.2 0.9
Lung FEV1/FVC ratio 2.6 13.2 36.2 -3.4 6.0 1.8 2.5 -5.6 -3.3 2.6 -3.2 -4.2 -3.1 -0.6
Lung FVC 0.7 3.3 7.7 -2.5 0.9 0.4 0.9 -2.7 -2.8 -0.6 -0.4 -1.9 -2.6 -1.7
Neuroticism 2.1 5.0 26.2 2.8 -0.3 1.1 -0.1 1.7 1.8 0.9 5.1 1.0 3.0 1.6
Chronotype (morning person) 1.2 2.7 11.2 1.3 -1.6 0.8 1.1 2.0 2.2 -0.6 -3.3 1.3 1.1 -0.2
Hair Pigment 0.1 3.7 13.5 2.0 -3.0 1.1 1.3 3.7 1.0 -0.4 0.6 1.8 2.4 0.3
Tanning 0.2 1.9 5.6 -2.4 0.2 -0.3 0.6 -0.9 -2.0 -0.8 -1.1 -1.4 -2.3 -0.4
Hand grip strength (left) 2.1 5.4 22.5 -2.8 -2.0 1.1 1.4 0.5 -2.4 -2.3 -4.7 -0.7 -2.5 -2.0
Number of treatments/medications taken 1.8 3.2 9.6 0.3 1.8 -2.3 -3.1 -0.4 -0.2 2.1 3.0 -1.5 0.2 -0.9
Average weekly spirits intake 0.9 1.1 6.5 -0.6 -0.9 -1.1 -2.5 -0.2 -0.5 0.5 1.3 -0.4 -0.7 -0.1
Sensitivity / hurt feelings 1.0 1.7 5.3 1.7 -0.9 0.8 0.6 1.1 1.4 1.3 2.3 0.1 2.0 -0.5
Frequency of depressed mood in last 2 weeks 0.9 1.3 6.0 1.2 -0.9 -0.0 -0.2 1.5 1.5 1.0 2.5 0.0 0.8 0.2
Hearing difficulty/problems: Yes 1.5 2.3 6.3 -1.8 0.2 -1.6 -2.5 -1.4 -1.6 -0.2 1.6 -0.9 -2.2 0.6
Relative age of first facial hair 2.2 4.6 10.6 -2.1 2.0 2.1 2.3 -3.2 -3.0 0.3 -1.7 -1.8 -1.8 -1.7
Other serious medical condition/disability diagnosed by doctor 2.6 3.3 7.2 -2.3 1.4 -0.9 -0.9 -2.7 -2.7 0.7 1.5 -2.1 -1.9 -1.7
Ever used hormone-replacement therapy (HRT) 0.6 0.8 3.1 0.5 1.0 -0.9 -0.9 -0.2 0.3 1.3 1.8 -0.4 0.8 0.7
Ever had hysterectomy (womb removed) 0.9 1.0 2.2 1.4 0.3 -1.0 -0.6 0.7 1.2 -0.1 1.2 1.1 1.5 0.8
Systolic blood pressure, automated reading 0.2 0.5 1.5 -0.4 1.1 0.2 0.1 -0.0 -0.9 0.5 -1.2 -0.8 0.2 -0.8
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 4.5 1.3 0.1 -2.1 -2.1 0.7 1.8 -0.2 0.1 0.8 1.4 -0.6
Angina 0.5 0.7 2.1 -1.0 0.4 -1.1 -0.9 -0.8 -0.8 0.8 0.7 -1.4 -0.2 -0.6
Medication for hormone replacement therapy 0.8 0.9 3.3 1.5 1.8 -0.9 -0.3 -0.3 0.7 0.4 0.3 -0.0 1.1 1.2
Vitamin and mineral supplements 1.9 2.5 7.3 1.5 -2.3 -0.9 -1.5 1.1 1.2 -1.0 1.2 2.7 2.2 0.0
Supplements: Zinc 0.8 0.8 2.8 0.6 0.6 1.2 1.7 0.9 1.5 0.7 0.1 -0.3 0.5 0.6
Medication: Co-codamol 1.8 2.1 5.4 1.7 -2.3 -0.0 -0.1 1.8 1.6 -1.3 0.9 2.3 1.3 -0.2
Medication: Metformin 2.6 3.7 10.1 2.8 1.6 0.5 -0.8 1.1 2.8 3.0 0.4 0.5 3.2 0.6
Diabetes (father) 0.3 0.3 1.7 -0.1 0.3 -0.3 -0.3 0.1 0.2 0.8 0.1 -0.9 0.2 -1.3
Diabetes (mother) 2.0 2.6 7.8 1.7 0.8 -0.9 -2.8 -0.0 1.3 1.1 2.2 0.4 1.2 2.6
Severe depression (siblings) 0.2 0.2 1.0 -0.1 -0.6 0.5 0.3 0.6 0.1 -0.2 1.0 0.2 0.6 -0.5
Pack years adult smoking proportion 1.3 1.9 4.5 1.7 0.7 -1.7 -0.5 0.7 1.4 2.1 -1.9 0.2 1.7 1.0
Impedance of leg (right) 2.3 10.9 35.5 2.3 -6.0 1.2 0.9 4.7 3.6 -3.0 3.5 3.7 1.8 2.2
Leg fat-free mass (left) 0.3 1.4 5.3 0.6 1.2 -1.3 -0.9 1.0 -0.1 2.3 -1.8 -0.9 0.8 -0.4
Trunk fat percentage 1.8 7.2 15.1 3.9 -1.2 -2.6 -2.6 3.7 3.3 2.3 0.0 1.8 3.9 1.1
Hand grip strength (right) 2.4 6.5 20.6 -2.4 -2.6 2.4 3.0 1.2 -2.5 -2.7 -4.5 -0.3 -1.7 -2.2
Townsend deprivation index at recruitment 2.4 3.3 8.0 1.4 1.5 -2.5 -2.7 -0.1 1.6 2.8 1.2 -1.6 0.4 2.0
Current tobacco smoking 1.5 2.4 6.9 1.0 1.6 -2.4 -2.6 -0.7 0.5 2.5 1.1 -1.1 0.8 0.5
Average weekly fortified wine intake 2.4 2.8 8.8 1.6 -2.3 -0.4 -0.9 2.3 0.7 -2.2 1.2 3.0 1.2 -0.2
Maternal smoking around birth 1.9 2.8 7.6 1.9 2.0 -1.1 -1.2 0.4 0.5 2.6 -1.3 -1.1 1.6 2.8
Fed-up feelings 1.3 2.3 17.2 1.1 0.3 -0.8 -2.2 0.4 0.5 0.4 4.2 0.5 0.7 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 10.7 0.8 -1.1 -0.1 -0.9 0.8 0.5 -0.4 3.3 0.6 0.4 -0.0
Relative age voice broke 0.3 0.5 1.3 0.1 0.7 0.9 1.1 -0.7 -0.5 -0.6 -0.6 0.2 0.0 -1.0
Taking other prescription medications 1.4 2.1 5.3 2.1 0.4 -0.2 -0.5 1.9 1.6 1.9 2.3 0.3 1.6 -0.1
Age when periods started (menarche) 2.0 4.7 13.5 -2.5 -2.8 1.3 0.3 -0.4 -2.7 -3.7 2.7 -0.1 -2.7 -0.9
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 3.0 1.4 0.5 1.2 1.7 0.6 0.8 1.5 0.5 0.1 1.2 1.3
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 5.8 2.3 -1.8 0.8 0.2 2.0 1.7 -0.5 0.1 2.4 2.1 0.7
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 2.5 -0.7 0.4 1.6 1.5 -0.2 0.6 1.1 0.8 -1.4 -0.7 -0.2
Qualifications: CSEs or equivalent 0.2 0.3 1.0 1.0 -0.3 -0.4 -0.0 0.4 1.0 -0.0 0.1 0.7 0.4 0.5
Serious illness, injury or assault to yourself 0.5 0.6 3.7 0.0 0.1 -0.8 -1.2 -0.3 -0.0 0.2 -0.4 0.0 -0.2 -1.9
High blood pressure 1.1 3.0 18.4 0.4 4.3 -0.6 -0.6 -1.7 -1.4 2.4 0.7 -1.7 0.6 0.6
Hayfever, allergic rhinitis or eczema 1.0 2.2 7.1 -1.9 0.4 -0.7 -0.6 -1.9 -1.9 -1.1 1.0 -1.1 -1.6 -2.7
Multivitamins +/- minerals 1.2 1.5 4.3 -0.6 2.1 0.2 0.7 -1.4 -0.7 1.1 -1.7 -2.0 -1.1 -0.4
Stomach or abdominal pain in last month 0.4 0.5 1.4 -0.7 -0.2 -0.7 -1.2 0.2 -0.7 0.9 0.5 -1.1 -0.6 -0.5
Supplements: Glucosamine 1.2 1.6 3.3 -1.8 0.6 1.5 1.8 -0.6 -1.0 -0.6 1.2 -0.8 -1.7 -1.4
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 5.7 -0.6 -1.2 -0.9 -0.8 0.3 -0.6 0.0 2.4 -0.2 -0.8 -0.8
Medication: Atenolol 0.6 0.7 1.6 -0.8 0.6 -1.1 -1.1 -1.3 -1.1 -0.3 1.1 -0.2 -0.3 -0.4
Medication: Levothyroxine sodium 0.3 0.6 4.3 0.1 0.5 0.0 -0.1 -1.0 -0.3 0.8 2.1 0.0 -0.3 -0.3
Sitting height 0.2 1.6 3.8 -1.9 -0.3 -1.9 -1.5 -0.2 -1.9 -1.2 0.1 -0.3 -1.6 -0.3
Chronic bronchitis/emphysema (father) 0.9 1.1 4.8 0.6 0.2 -1.7 -2.2 0.4 1.3 0.9 0.0 0.0 0.8 -0.4
High blood pressure (mother) 1.4 2.0 6.9 -0.7 2.6 -1.2 -1.1 -1.9 -0.4 1.3 -1.7 -1.1 -0.8 1.4
Body mass index (BMI) 1.7 7.1 24.6 3.3 2.8 -2.4 -2.5 1.1 1.9 5.0 -1.8 -0.4 3.5 1.5
Impedance of leg (left) 2.2 10.8 39.3 1.9 -6.3 0.9 0.9 4.5 3.2 -3.6 3.6 3.7 1.5 1.5
Leg predicted mass (left) 0.3 1.4 5.3 0.5 1.3 -1.3 -0.9 0.9 -0.2 2.3 -1.8 -1.0 0.6 -0.5
Trunk fat mass 1.4 6.1 13.6 3.5 -0.9 -2.5 -2.3 3.7 2.8 2.4 -0.4 1.4 3.5 0.9
Waist circumference 1.5 5.7 19.6 3.1 1.5 -2.2 -2.2 1.9 2.0 4.4 -0.8 0.0 3.1 1.9
Number of incorrect matches in round 0.5 0.9 4.3 0.5 1.4 0.1 0.5 -0.2 0.8 2.1 -0.8 -0.8 0.9 0.2
Past tobacco smoking 2.0 3.8 7.6 2.6 -0.8 2.0 1.5 2.3 2.6 -0.3 -0.3 2.8 2.4 1.4
Alcohol usually taken with meals 0.7 1.1 5.4 0.3 -0.4 1.7 2.3 0.8 0.6 -0.3 -0.7 0.4 -0.4 1.4
Nervous feelings 1.2 2.3 15.6 1.4 -1.2 0.6 0.4 1.3 0.8 0.1 4.0 0.8 1.5 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 6.1 1.4 1.0 0.4 0.1 0.3 1.4 2.5 1.7 -1.0 0.8 -0.0
Hearing difficulty/problems with background noise 0.6 0.9 3.2 -0.6 1.2 -1.0 -1.4 -0.4 -0.4 0.5 1.8 -0.8 -1.0 0.1
Hair/balding pattern: Pattern 2 1.1 1.3 2.7 -0.9 1.7 1.2 1.3 -1.5 -1.2 0.2 0.7 -1.2 -0.6 -1.4
Had menopause 0.9 1.1 3.0 -0.2 1.5 -1.2 -1.4 -1.7 -0.6 0.6 1.5 -0.1 0.4 -0.5
Had other major operations 0.1 0.2 0.5 0.4 0.7 0.5 0.6 0.1 0.1 0.5 -0.1 0.0 0.2 -0.3
Forced vital capacity (FVC) 0.9 3.6 8.5 -2.9 -2.0 0.7 1.2 -0.5 -2.5 -2.5 -0.6 -1.1 -2.9 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.3 12.0 2.4 -2.5 0.7 -0.2 3.5 2.3 -0.8 0.9 2.9 2.5 0.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.9 1.1 -0.1 -0.3 -0.6 0.9 1.0 -0.0 1.4 1.2 0.7 0.3
Qualifications: None of the above 0.6 1.3 6.8 0.5 -0.3 -1.8 -2.6 0.5 0.4 0.2 1.7 -0.6 0.2 0.1
Financial difficulties in last 2 years 1.1 1.5 4.2 2.1 0.4 1.3 0.9 1.7 1.6 1.0 -0.0 0.4 1.6 0.6
Mouth/teeth dental problems 0.5 0.8 2.0 -0.4 1.2 1.1 1.3 -1.4 -0.4 0.3 -1.1 -0.3 -0.8 -0.2
Heart attack 2.5 3.1 7.6 -2.4 0.2 -1.0 -1.4 -2.0 -2.6 -1.9 0.8 -0.2 -1.8 -2.7
Allergy 0.4 1.0 1.7 1.3 -0.2 1.1 0.9 0.9 1.3 0.6 -1.2 0.8 1.2 1.1
Pain all over the body in last month 1.0 1.0 4.2 1.2 -0.4 -0.7 -0.3 1.1 1.5 0.7 2.0 0.4 0.8 -0.8
Diabetes (self-reported) 2.2 3.4 9.0 2.9 1.5 -0.0 -0.4 1.4 2.3 3.0 -0.1 0.3 3.0 0.9
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 9.8 -0.8 -3.1 -0.3 -0.9 1.4 -0.4 -1.9 2.9 0.8 -0.5 0.1
Medication: Ramipril 0.2 0.3 1.2 0.3 0.5 -0.3 -0.5 0.3 -0.6 0.9 -0.5 -0.3 1.1 -0.2
Medication: Simvastatin 0.9 1.3 4.1 -0.8 2.0 -1.1 -1.0 -1.2 -0.6 1.7 0.8 -1.3 -0.2 -0.3
Fluid intelligence score 1.4 2.9 8.7 -0.5 2.6 -0.8 -0.2 -1.6 0.2 3.0 -2.2 -2.3 -0.7 1.6
Illnesses of siblings 1.4 2.0 6.6 -1.0 -1.9 2.4 2.6 0.3 -0.2 -1.1 -0.8 0.2 -1.4 0.8
Neuroticism score 2.8 5.7 26.5 3.3 -0.9 0.9 -0.2 2.3 2.0 0.7 5.2 1.5 3.3 1.2
Weight 0.9 4.5 9.1 2.9 0.1 -2.3 -2.1 3.0 2.0 2.7 -0.7 0.8 3.0 0.9
Impedance of arm (right) 1.3 6.2 22.9 -0.6 -4.8 -1.1 -1.7 1.6 0.9 -4.4 3.1 2.4 -1.5 0.4
Arm fat percentage (right) 1.4 5.3 11.0 3.0 1.2 -2.9 -3.0 1.8 2.3 3.3 -1.4 0.4 2.8 1.4
Trunk fat-free mass 0.1 0.6 2.3 0.1 0.5 -0.5 0.0 1.5 -0.5 0.9 -1.4 -0.6 0.2 -0.3
Hip circumference 1.5 6.3 14.9 3.6 -1.4 -1.9 -2.1 3.9 3.0 2.2 -1.2 1.9 3.3 1.2
Time employed in main current job 1.2 1.3 6.9 -1.8 0.5 -0.6 -0.7 -1.3 -2.6 -0.4 0.3 -0.4 -1.2 -0.5
Alcohol intake versus 10 years previously 2.3 3.4 10.8 1.6 -2.2 -0.8 -0.8 3.3 2.1 -2.1 0.2 2.7 1.1 -0.4
Father’s age at death 0.7 1.0 2.2 -1.4 -0.1 1.5 1.1 -0.3 -0.7 -1.0 -0.3 -0.6 -1.1 -1.4
Worrier / anxious feelings 2.3 4.4 24.6 2.2 -1.2 0.6 -0.9 2.0 1.9 0.1 5.0 1.2 1.8 1.9
Frequency of tiredness / lethargy in last 2 weeks 2.1 3.4 12.8 2.0 -1.3 -0.8 -1.8 2.0 2.5 1.0 3.6 1.0 1.5 0.7
Falls in the last year 1.2 1.6 4.4 -1.2 0.5 -0.3 -0.9 -1.1 -1.5 0.2 2.1 -1.0 -1.4 -1.9
Hair/balding pattern: Pattern 3 0.6 0.9 3.4 0.4 -1.7 0.3 0.4 0.6 0.3 -1.0 0.5 1.0 -0.2 1.8
Number of live births 0.4 0.6 2.0 0.5 -1.1 0.0 0.4 0.9 0.2 -1.4 0.3 1.2 0.4 -0.2
Forced expiratory volume in 1-second (FEV1) 1.0 3.5 8.1 -2.8 -0.7 1.1 1.6 -1.2 -2.7 -1.6 -1.6 -1.5 -2.8 -1.6
Pulse rate 0.5 0.8 2.4 1.6 1.1 -0.7 0.1 0.2 0.7 1.1 -0.7 0.1 1.5 0.4
Happiness 0.9 1.1 4.0 1.0 -0.0 -2.0 -1.7 -0.1 0.3 -0.1 1.5 0.6 1.0 0.2
Noisy workplace 0.6 0.7 3.0 -0.0 -0.2 0.0 -0.3 -0.2 -1.2 -1.2 1.7 1.2 -0.0 -0.3
Qualifications: A levels/AS levels or equivalent 0.4 0.8 3.3 -0.4 -1.2 -0.7 0.5 0.4 0.3 -1.1 -1.8 0.4 -0.9 0.8
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.4 8.8 0.0 3.0 1.0 1.4 -2.1 -0.5 2.1 -1.1 -1.9 -0.6 -0.3
Mouth/teeth dental problems: Dentures 0.6 1.1 3.4 0.1 -1.0 -0.6 -1.2 1.4 -0.5 -1.2 0.6 0.6 1.1 -1.8
Asthma 0.7 1.3 4.9 1.2 -1.6 -0.6 0.1 2.2 1.4 -0.1 0.9 0.8 1.3 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.6 3.8 0.7 0.1 0.6 0.1 0.2 0.7 1.9 -0.0 -0.9 0.2 0.0
Medication: Cholesterol lowering 0.6 0.9 4.2 -0.8 1.5 -0.3 -0.4 -0.9 -1.3 0.1 2.1 -0.3 -0.1 -0.4
Depression (self-reported) 0.6 0.7 2.2 -0.9 -1.1 0.8 -0.1 0.2 -0.4 -0.1 1.3 -0.9 -1.5 -0.5
Medication: Lansoprazole 1.1 1.2 5.7 1.2 0.9 -0.4 -1.1 0.5 1.4 2.4 0.4 -0.4 1.3 -0.2
Prospective memory result 1.4 1.7 4.5 1.3 0.1 -1.7 -2.0 0.6 0.6 0.4 1.8 0.5 1.0 2.1
Lung cancer (father) 2.3 2.7 8.0 2.8 -0.1 -0.1 -0.2 1.1 2.8 1.4 -1.0 1.5 2.4 1.5
Illnesses of mother 4.2 5.1 23.2 0.2 -3.0 3.5 4.8 1.8 -0.4 -2.1 -0.6 1.1 0.7 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 6.0 -2.3 -1.2 0.6 0.6 -0.8 -2.3 -1.9 -0.4 -0.6 -2.4 -1.9
Pulse wave Arterial Stiffness index 1.4 1.7 5.9 -0.2 2.4 -1.7 -1.1 -1.9 -1.4 1.0 0.5 -1.4 -0.1 -0.1
Impedance of arm (left) 1.7 7.7 33.2 -0.2 -5.8 -0.9 -1.3 2.1 1.1 -4.9 3.1 3.1 -0.8 0.1
Arm fat mass (right) 1.3 5.5 13.1 2.9 1.1 -2.8 -2.7 2.3 2.1 3.6 -1.5 0.2 3.0 1.3
Trunk predicted mass 0.1 0.6 2.0 -0.1 0.5 -0.5 -0.0 1.4 -0.6 0.9 -1.4 -0.6 0.0 -0.3
Standing height 0.8 7.7 33.5 -0.5 -5.8 -0.1 0.5 4.5 0.3 -4.2 2.3 2.4 -0.5 -1.1
Length of working week for main job 3.9 4.4 11.9 3.4 -1.0 0.4 0.6 2.9 2.4 -0.2 0.5 2.6 3.4 1.3
Exposure to tobacco smoke at home 1.1 1.2 2.8 1.4 -1.3 0.6 -0.6 0.5 0.7 -0.4 1.7 1.4 1.7 0.3
Breastfed as a baby 1.8 2.3 5.4 -2.0 0.7 2.0 1.9 -1.5 -2.3 -0.9 0.1 -0.3 -1.8 -1.0
Tense / ‘highly strung’ 0.6 1.0 4.4 1.0 0.4 0.1 0.1 0.3 0.6 1.6 2.1 -0.8 1.0 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 4.1 -0.0 -0.8 1.6 0.7 0.2 -0.5 -0.7 2.0 -0.1 0.1 -0.6
Hair/balding pattern: Pattern 4 0.5 1.2 4.8 -0.2 0.4 -1.8 -2.2 0.8 0.3 1.5 0.1 -0.8 0.0 1.2
Birth weight of first child 0.4 0.7 2.6 -1.3 0.6 -1.0 -1.6 -0.2 -0.6 0.5 0.5 -0.6 -1.1 0.0
Peak expiratory flow (PEF) 2.7 6.2 15.1 -3.9 -0.3 0.6 1.3 -1.9 -3.9 -1.9 -2.8 -1.9 -3.4 -2.4
Pulse wave reflection index 0.2 0.3 0.5 0.1 0.5 -0.6 0.0 -0.7 -0.4 0.7 0.6 -0.7 0.1 0.5
Ever highly irritable/argumentative for 2 days 1.7 2.0 7.2 0.9 0.8 -2.7 -2.6 0.8 1.4 1.1 -0.6 0.5 0.9 1.3
Loud music exposure frequency 0.6 0.7 4.1 0.3 0.2 1.2 0.6 0.0 0.8 0.5 -2.0 0.1 0.5 -0.4
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.9 0.3 -0.3 0.9 0.9 -0.5 0.2 0.4 -0.8 -0.0 0.3 -0.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.6 1.8 0.5 -1.1 0.2 0.6 0.8 1.1 -0.1 -0.3 0.7 0.3 1.3
Blood clot in the leg (DVT) 0.3 0.3 1.2 -0.1 0.6 0.6 0.2 0.3 0.2 1.1 0.8 -1.0 -0.0 -0.1
Medication: Paracetamol 1.5 2.5 7.3 1.7 -0.9 -1.0 -2.1 2.0 2.1 0.5 2.7 0.6 1.0 -0.5
Headache pain in last month 0.9 1.5 4.5 2.1 -0.5 -0.0 -0.7 1.7 1.8 1.1 -0.1 0.6 1.8 0.6
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 4.7 1.1 -2.2 1.0 1.1 1.1 1.5 -1.1 -1.6 1.2 0.7 0.3
Glaucoma (self-reported) 0.3 0.3 0.7 -0.5 0.2 -0.8 -0.7 -0.2 -0.8 0.1 0.8 -0.3 0.2 0.8
Gout (self-reported) 0.5 0.6 2.6 -0.4 0.4 -1.6 -0.6 0.4 -0.7 -0.3 -0.4 -0.1 -1.1 -1.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 1.1 0.3 0.0 -0.3 -0.1 -0.2 -0.1 0.1 1.0 0.9 0.2 -0.9
Medication: Amlodipine 1.3 1.9 5.5 -1.0 2.3 -0.1 0.0 -1.9 -2.1 -0.1 -0.5 -0.9 -0.8 -2.0
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.6 0.0 -0.1 0.2 -0.3 0.4 0.5 0.1 0.5 0.1 0.8 0.3
Birth weight 1.2 2.6 6.6 -2.4 -2.1 -0.1 -0.9 -0.2 -2.3 -2.6 -0.5 0.1 -1.6 -1.6
Chronic bronchitis/emphysema (mother) 1.2 1.4 4.0 1.8 -0.2 -0.4 -0.4 1.5 2.0 1.4 -0.9 -0.0 0.9 1.4
High blood pressure (siblings) 0.9 1.2 4.6 0.1 2.2 -1.4 -1.4 -1.0 -1.0 0.8 0.2 -0.7 0.5 -1.2
Forced vital capacity (FVC), Best measure 0.7 2.7 8.2 -1.9 -2.9 0.3 0.2 0.4 -1.7 -2.7 0.8 0.1 -2.1 -1.5
Body fat percentage 2.0 7.7 16.8 4.1 -0.5 -2.6 -2.5 3.6 3.4 3.0 -0.4 1.5 4.1 1.4
Leg fat percentage (right) 2.9 10.7 24.7 5.0 0.0 -1.9 -1.9 3.9 4.3 3.9 -0.1 1.6 5.0 3.1
Arm fat-free mass (right) 0.3 1.4 4.5 0.9 0.8 -0.3 0.4 1.9 0.1 2.1 -1.8 -0.5 1.5 -0.3
Exposure to tobacco smoke outside home 1.2 1.6 4.5 1.6 -0.7 1.0 -0.4 2.1 1.5 0.6 -0.7 0.8 2.0 1.1
Comparative body size at age 10 0.4 1.1 2.1 -1.3 0.6 -1.4 -1.4 -0.8 -1.0 0.9 -1.2 -1.1 -0.8 0.2
Number of full brothers 0.9 1.1 3.1 1.8 0.1 -0.0 0.2 1.5 1.5 0.6 -0.9 1.0 1.7 -0.0
Worry too long after embarrassment 3.8 6.4 15.3 3.4 -0.8 2.4 1.3 2.6 2.7 1.5 3.6 1.9 3.9 1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.6 10.8 -1.5 -0.5 -0.5 -1.3 -0.8 -1.8 -0.7 3.3 -1.2 -2.6 -0.4
Wheeze or whistling in the chest in last year 0.6 1.0 2.5 0.6 -0.8 -1.1 -1.6 1.5 1.3 0.7 0.9 0.1 0.7 0.7
Number of children fathered 0.5 0.5 2.0 -0.8 -0.0 -0.1 -1.0 -0.2 -0.3 -1.4 0.3 0.5 -0.7 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.6 -0.6 0.2 1.1 1.3 0.1 -0.1 0.8 -0.8 -1.2 0.0 0.6
Age at first live birth 0.9 1.6 4.2 -2.0 -1.0 1.2 1.2 -0.4 -1.6 -1.0 0.1 -0.8 -1.9 -1.4
Pulse wave peak to peak time 1.9 2.2 7.8 0.2 -2.8 1.9 1.4 2.3 1.5 -1.1 -0.4 1.5 0.1 -0.0
Health satisfaction 1.1 1.5 4.1 2.0 0.7 -1.4 -0.8 0.2 0.8 2.0 0.8 0.4 1.7 0.7
Shortness of breath walking on level ground 0.7 0.8 2.5 1.1 0.1 -1.0 -1.0 0.6 0.4 1.6 -0.3 -0.3 1.5 0.4
Qualifications: College or University degree 0.3 0.9 5.2 -0.2 -0.2 -0.5 -0.2 -0.4 0.4 -0.4 1.8 0.1 -0.7 2.3
Eye problems/disorders: None of the above 0.3 0.4 1.1 0.2 0.9 0.4 1.0 0.4 0.6 0.4 -0.8 -0.4 -0.2 -0.5
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.4 0.1 0.1 0.0 -0.1 -0.2 -0.1 0.2 0.6 -0.3 -0.0 0.7
Emphysema/chronic bronchitis 1.1 1.3 4.9 -0.2 0.7 -0.9 -0.9 -0.2 0.2 1.6 -1.4 -1.4 -0.6 2.2
Medication for pain relief, constipation, heartburn 0.9 1.5 4.7 -1.0 -1.5 0.5 1.2 -0.0 -0.8 -2.2 -1.7 1.1 -0.5 1.2
Neck or shoulder pain in last month 1.0 1.4 4.2 -0.0 2.0 -1.0 -1.3 -0.9 -1.0 1.3 -0.4 -0.9 0.4 -2.1
Medication: Blood pressure 1.2 2.2 7.0 -1.5 2.6 -1.2 -1.4 -1.6 -1.7 0.7 0.6 -1.7 -1.1 -1.0
Angina (self-reported) 0.7 0.9 2.4 -1.0 0.5 -1.2 -1.1 -1.0 -0.8 0.9 0.6 -1.5 -0.3 -0.5
Migraine (self-reported) 0.5 0.6 2.1 1.0 0.5 -0.5 -0.5 0.1 0.8 0.9 -0.1 -0.1 1.1 1.4
Medication: Ibuprofen 0.9 1.0 5.2 1.1 0.2 1.0 0.3 0.6 1.3 2.3 0.4 -1.0 0.7 -0.4
Medication: Allopurinol 0.4 0.5 3.5 -0.0 0.5 -0.1 0.7 -0.1 -0.8 -0.3 -0.8 0.2 -0.5 -1.9
Medication: Omeprazole 1.4 1.7 6.5 1.6 -0.7 -1.3 -1.3 0.7 1.6 -0.0 2.5 1.2 1.0 -0.3
Medication: Seretide 50 evohaler 1.6 1.8 4.4 -1.5 2.1 -1.4 -0.9 -1.4 -1.1 0.8 -0.3 -1.9 -1.4 0.9
Mean time to correctly identify matches 1.0 1.9 4.8 -0.4 1.9 -2.0 -2.0 -1.6 -1.2 0.5 2.2 -0.4 -0.2 0.1
Heart disease (mother) 1.3 1.6 6.4 0.5 0.6 -2.1 -2.5 -0.3 -0.1 0.9 2.0 0.3 0.6 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.1 2.5 8.3 -2.5 -1.0 0.9 1.4 -0.3 -2.9 -1.4 -1.5 -0.9 -1.5 -1.6
Whole body fat mass 1.5 6.3 12.9 3.5 -0.1 -2.6 -2.3 3.4 2.7 3.2 -0.7 0.9 3.6 1.3
Leg fat mass (right) 1.9 7.3 14.9 3.8 0.5 -2.2 -2.0 3.4 3.1 3.8 -0.9 0.7 3.9 2.2
Arm predicted mass (right) 0.3 1.7 5.7 1.1 0.8 0.1 0.8 2.1 0.4 2.4 -1.8 -0.6 1.6 -0.1
Pulse rate, automated reading 0.9 2.8 10.2 -0.4 3.2 -0.9 -0.5 -2.6 -0.7 2.0 -0.8 -2.2 -0.8 -1.4
Alcohol intake frequency. 4.5 10.4 25.0 4.5 -2.6 -0.7 -1.8 4.2 4.9 -1.6 0.9 5.0 3.7 0.6
Comparative height size at age 10 0.6 3.4 14.4 0.5 -3.8 -1.3 -1.6 2.9 1.1 -1.4 2.0 1.7 0.4 0.2
Number of full sisters 2.3 2.8 11.4 2.7 0.3 -0.0 -0.1 2.1 3.4 1.1 -1.6 0.7 1.6 1.1
Suffer from ‘nerves’ 1.6 2.6 14.9 1.4 -1.6 1.6 1.0 1.8 0.9 -0.1 3.9 0.4 1.1 -0.2
Overall health rating 1.9 4.0 16.3 0.5 0.8 -3.1 -4.0 -0.3 0.0 2.2 3.4 -0.5 0.5 0.1
Chest pain or discomfort 0.4 0.5 1.6 -0.3 -0.0 -0.3 -0.7 -0.2 0.2 0.9 1.2 -1.0 -0.3 -1.3
Had major operations 0.5 0.6 1.2 1.0 -0.8 1.1 1.1 1.0 0.4 0.5 -0.2 0.4 1.0 0.0
Age at last live birth 1.0 1.4 4.6 0.5 -2.2 1.4 1.3 1.2 0.3 -1.1 -0.2 0.9 0.9 -1.5
Family relationship satisfaction 0.7 0.9 2.0 1.0 0.8 -1.2 -1.0 -0.1 0.9 0.8 -1.2 0.3 1.0 1.4
Leg pain on walking 0.7 0.9 4.9 -0.7 -0.1 0.0 0.1 -0.3 -1.1 -0.8 1.2 -0.5 -0.7 -2.2
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 2.0 1.1 -0.1 -0.1 0.3 1.3 0.7 -0.1 -0.5 1.0 1.4 0.4
Commuting to job workplace: Car/motor vehicle 0.5 0.6 4.0 0.2 -0.4 1.0 2.0 0.3 0.4 0.1 -0.9 -0.1 -0.1 0.7
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 4.6 -0.7 -2.2 -0.8 -0.7 0.8 -0.7 -1.4 0.4 1.0 0.5 0.8
Medication: Aspirin 3.4 4.4 9.4 -2.4 3.0 -0.9 -1.2 -3.1 -2.4 1.6 0.9 -2.9 -1.7 -1.4
Supplements: Vitamin C 0.5 0.6 2.3 -0.5 0.5 1.3 1.5 -0.0 -0.3 -0.0 -0.4 -0.5 -0.9 0.5
Knee pain experienced in last month 0.4 0.6 1.7 -0.5 0.2 0.9 1.2 -0.3 -0.4 -0.9 1.1 0.1 -0.1 -1.3
Hypertension (Self-reported) 1.0 2.9 16.8 -0.1 4.1 -0.6 -0.8 -1.8 -1.7 2.0 0.6 -1.8 0.3 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 3.8 1.7 0.9 -0.4 -0.4 0.3 0.7 2.0 0.1 -0.4 1.5 0.3
Illnesses of father: Heart disease 1.7 2.4 5.9 -1.6 2.4 1.1 1.3 -2.4 -1.4 0.9 0.1 -1.7 -1.9 0.1
Illnesses of siblings: Diabetes 1.5 1.9 5.2 1.7 1.3 -2.0 -2.3 0.4 1.7 0.9 -0.0 0.6 1.6 -0.3
Smoking status: Previous 1.8 2.7 6.9 -2.5 0.7 -1.4 -0.7 -2.0 -2.6 -0.7 0.4 -1.7 -2.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.7 -0.8 -0.8 0.7 1.2 -0.7 -1.3 -1.3 0.3 0.4 -0.9 -1.0
Whole body fat-free mass 0.2 1.0 3.1 0.3 0.9 -0.7 -0.2 1.3 -0.3 1.7 -1.8 -0.8 0.5 -0.5
Leg fat-free mass (right) 0.2 1.3 3.8 0.1 1.2 -1.4 -0.8 0.6 -0.6 1.9 -1.9 -1.1 0.3 -0.9
Arm fat percentage (left) 1.5 5.9 11.2 3.3 0.7 -2.9 -3.0 2.2 2.5 3.1 -1.3 0.9 3.3 1.4
Average weekly red wine intake 0.3 0.5 3.3 0.7 0.1 -0.2 0.1 0.6 0.5 0.2 -0.0 0.3 0.9 1.8
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.7 -0.4 -0.6 0.9 -0.5 0.2 -0.0 -0.2 -0.1 -0.3 -0.6 -0.7
Mood swings 1.5 2.8 12.0 1.5 0.8 -0.3 -1.3 0.7 0.6 0.9 3.4 -0.1 0.8 3.5
Loneliness, isolation 0.9 1.2 6.8 0.3 0.1 -1.2 -1.7 -0.0 -0.6 -0.4 2.6 0.0 0.0 -1.2
Long-standing illness, disability or infirmity 1.2 1.9 4.5 -0.0 1.0 -2.1 -2.0 -0.3 -0.1 1.7 2.0 -0.6 -0.1 -1.9
Ever had bowel cancer screening 1.0 1.2 5.9 -1.4 -0.0 1.1 0.9 0.0 -1.1 -0.2 2.4 -0.8 -1.1 0.3
Diabetes diagnosed by doctor 3.0 4.9 14.9 3.5 1.6 0.0 -0.6 1.9 3.1 3.1 0.2 0.7 3.9 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.3 1.2 0.1 0.4 -0.2 -0.1 0.2 -0.4 -1.1 0.9 0.7 -0.2 -0.1
Friendships satisfaction 0.6 0.7 2.0 0.8 0.7 -1.4 -0.8 0.1 1.2 1.3 -0.2 -0.1 0.8 0.3
Qualifications: nursing, teaching 0.4 0.7 2.2 -1.2 0.8 -0.0 0.3 -0.8 -0.3 -0.3 -0.6 0.0 -1.5 1.4
Commuting to job workplace: Walk 0.3 0.3 1.3 -0.2 -0.6 0.6 0.2 0.0 0.3 -0.2 1.1 0.2 -0.9 -0.1
Eye problems/disorders: Cataract 0.9 1.0 4.7 -1.3 -0.4 1.3 0.4 -1.5 -2.2 -0.3 0.0 -0.4 -0.7 -0.4
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.3 1.0 -1.9 -1.2 -1.0 1.7 1.5 -0.2 2.1 0.9 0.6 0.1
Medication for cholesterol 1.7 2.6 8.1 -1.7 -2.7 1.5 1.0 0.4 -0.9 -2.8 0.3 1.0 -1.7 -1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.7 0.4 -0.4 -0.9 0.1 0.3 0.1 -0.7 0.1 0.4 0.1 -0.0
Back pain experienced in last month 1.3 1.9 6.9 1.7 -0.0 -0.9 -1.4 1.7 1.8 -0.1 2.6 1.2 1.0 0.2
Mineral and other dietary supplements 1.0 1.4 4.0 1.5 -0.4 -0.9 -1.5 1.0 0.6 0.3 -0.7 1.1 1.6 2.0
Breast cancer (self-reported) 0.3 0.3 1.0 0.3 0.7 0.6 -0.1 -0.8 -0.4 0.9 -0.1 -0.0 0.4 1.0
Asthma (self-reported) 0.5 1.0 3.8 0.8 -1.5 -0.8 -0.2 1.9 1.1 -0.2 0.8 0.6 0.9 0.2
Osteoporosis (self-reported) 1.2 1.5 5.5 -1.5 -0.3 2.0 2.3 -0.6 -0.8 -0.3 -0.7 -1.0 -1.2 -0.8
Osteoarthritis (self-reported) 0.7 0.8 5.5 0.2 1.0 -0.3 -0.1 -0.2 0.3 0.9 2.4 -0.3 1.0 -0.8
Medication: Aspirin 4.0 5.3 12.0 -2.9 3.0 -0.7 -1.1 -3.5 -2.9 1.3 0.2 -3.1 -2.4 -1.5
Medication: Gliclazide 0.5 0.6 2.8 -0.3 0.7 0.9 -0.0 0.1 0.2 0.9 1.1 -0.3 0.5 -1.7
Illnesses of father: None of the above (group 1) 0.7 0.9 4.3 0.1 -2.1 -0.0 0.5 2.0 0.4 -0.5 0.6 0.7 0.4 0.0
Smoking status: Current 1.2 1.9 5.4 0.7 1.4 -2.2 -2.3 -0.8 0.2 2.2 0.9 -1.1 0.6 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.9 2.1 -1.0 0.2 1.5 1.4 -0.5 -0.4 1.0 -0.5 -1.4 -0.9 -0.2
Whole body water mass 0.2 1.0 3.3 0.4 1.0 -0.8 -0.2 1.3 -0.3 1.7 -1.8 -0.9 0.6 -0.6
Leg predicted mass (right) 0.2 1.2 3.6 0.2 1.2 -1.3 -0.8 0.6 -0.5 1.8 -1.9 -1.0 0.4 -0.9
Arm fat mass (left) 1.4 5.8 11.6 3.3 0.7 -2.7 -2.6 2.6 2.3 3.4 -1.4 0.6 3.4 1.3
Number of self-reported non-cancer illnesses 1.2 2.1 6.1 1.4 1.6 -1.2 -1.4 0.6 0.7 2.5 2.1 -1.0 1.7 0.2
Average weekly champagne plus white wine intake 1.1 1.5 4.5 0.7 -1.6 0.3 1.1 2.1 1.0 -0.2 -1.5 1.4 1.3 0.5
Miserableness 1.6 2.8 26.0 0.4 -0.6 -0.3 -1.3 0.2 -0.0 0.1 5.1 -0.4 -0.2 1.7
Guilty feelings 2.1 3.2 27.5 1.1 -1.2 0.8 -0.1 1.1 0.5 0.5 5.2 0.1 1.5 0.5
Wears glasses or contact lenses 1.5 1.7 6.6 -1.6 1.2 1.3 1.2 -1.7 -2.6 0.3 -0.5 -1.1 -0.9 -0.2
Ever taken oral contraceptive pill 0.7 0.8 3.4 0.1 -1.5 1.1 1.8 0.3 0.0 -0.6 -1.1 0.1 -0.2 -0.5
Hearing aid user 0.9 1.1 3.9 -1.0 0.1 -0.6 -1.6 -0.7 -1.4 -0.7 0.8 -0.1 -2.0 0.3
Mother’s age at death 0.6 0.7 3.2 -0.9 -0.4 1.8 1.1 -0.6 -0.2 -0.5 0.1 -0.7 -0.8 -0.9
Financial situation satisfaction 3.8 4.7 13.9 3.7 -0.0 -0.1 -0.8 2.5 3.4 1.4 0.5 2.1 3.3 1.4
Tinnitus: Yes, now most or all of the time 2.1 2.4 5.7 -2.2 0.8 -0.3 -0.8 -2.2 -2.2 0.4 1.3 -1.6 -2.4 -1.1
Commuting to job workplace: Public transport 1.0 1.2 5.9 -0.8 0.4 -2.4 -2.1 -0.9 -0.4 -0.5 0.4 -0.0 -0.3 0.8
Eye problems/disorders: Glaucoma 0.5 0.6 1.8 -0.6 -0.3 -1.4 -1.0 -0.0 -0.9 -0.2 0.9 -0.3 0.2 1.3
Medication: Blood pressure 0.7 1.3 5.8 1.2 2.4 -0.6 -0.3 -0.6 0.1 1.9 -0.2 -0.4 1.6 0.5
Pain type(s) experienced in last month: Hip pain 1.5 1.9 14.2 0.2 -0.0 1.1 0.7 0.4 0.2 -1.4 0.7 1.3 0.9 -3.8
Supplements: Fish oil (including cod liver oil) 1.6 2.0 4.3 -1.7 1.4 0.3 0.2 -2.1 -1.3 -0.0 0.5 -1.6 -2.0 -2.1
High cholesterol (Self-reported) 0.5 0.9 2.2 -0.7 1.5 -0.8 -1.0 -0.9 -0.4 1.0 1.4 -0.9 -0.4 -0.6
Medication: Bendroflumethiazide 0.5 0.8 2.7 -0.4 1.6 0.3 -0.3 -1.0 -0.9 0.3 1.2 -0.9 -0.1 -1.1
Medication: Paracetamol 2.3 3.5 7.5 1.9 -1.1 -1.8 -2.7 2.6 2.2 0.2 2.7 1.1 1.5 -0.9
Medication: Lisinopril 2.1 2.8 4.6 -1.7 2.0 -1.6 -1.6 -2.0 -1.4 1.8 -0.4 -2.1 -2.0 -0.3
Medication: Atorvastatin 0.6 0.7 2.0 0.8 -0.1 -0.7 -0.6 0.8 0.8 0.1 1.2 0.5 1.3 -1.4
Illnesses of father: High blood pressure 0.5 0.6 1.7 -0.1 1.3 0.3 0.8 -0.9 -0.8 -1.0 -1.2 0.2 -0.2 -0.8
Alcohol drinker status: Never 4.1 5.0 11.7 3.0 -1.8 0.8 -0.2 3.4 3.1 -0.9 1.4 2.8 2.9 0.9
Ever smoked 1.6 2.7 9.0 -1.8 0.7 -1.9 -1.6 -1.3 -1.5 1.1 1.1 -3.0 -2.2 -0.3
Basal metabolic rate 0.2 1.3 3.9 0.9 0.7 -1.2 -0.7 1.8 0.3 2.0 -1.6 -0.5 1.1 -0.2
Leg fat percentage (left) 2.6 9.3 22.5 4.6 0.1 -2.1 -1.8 3.6 4.0 3.7 -0.2 1.4 4.7 2.5
Arm fat-free mass (left) 0.4 1.9 7.7 1.3 1.3 -0.5 0.0 1.9 0.6 2.8 -1.7 -0.8 1.5 0.1
Number of operations (self-reported) 0.3 0.5 2.2 0.6 -0.2 0.8 1.5 0.4 0.1 0.6 0.3 -0.5 0.7 -0.7
Average weekly beer plus cider intake 0.7 1.1 4.7 0.6 0.7 0.7 1.0 -0.3 -0.2 0.5 -1.8 -0.7 0.4 2.2
Irritability 1.2 2.0 4.7 1.8 1.4 -1.8 -2.2 0.1 1.7 1.0 1.5 0.1 1.6 0.9
Risk taking 0.5 0.7 1.7 1.0 0.2 -1.0 -0.1 0.8 0.1 1.2 -1.2 -0.2 0.7 1.3
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.5 -0.2 -0.7 0.2 0.5 -0.1 -0.5 -0.0 -0.4 -0.1 -0.3 -0.5
Fractured/broken bones in last 5 years 1.0 1.3 5.1 -0.9 -1.3 1.2 2.3 0.2 -0.3 0.3 -0.3 -1.3 -0.7 -1.5
Age started oral contraceptive pill 1.5 1.8 7.3 -0.6 -2.6 0.1 -0.2 1.4 0.3 -1.5 2.7 1.0 -0.1 -0.7
Diastolic blood pressure, automated reading 0.9 2.7 12.4 0.6 3.5 -0.9 0.0 -1.4 -0.4 2.3 -2.2 -1.9 0.5 0.1
Ever depressed for a whole week 0.5 0.6 1.7 0.5 0.9 -0.7 -1.3 -0.7 0.3 0.7 1.3 0.4 0.5 0.5
Unable to work because of sickness or disability 0.7 1.0 2.8 0.6 0.0 -1.6 -1.7 1.0 1.1 0.5 0.7 -0.3 -0.6 -1.3
Commuting to job workplace: Cycle 0.9 1.0 4.1 -1.1 -0.6 -0.4 -0.2 -0.3 -0.8 -2.0 0.8 0.9 -1.2 -1.4
Myopia 0.3 0.5 1.2 0.9 1.0 -0.3 -0.5 -0.2 0.8 0.4 -0.8 0.9 1.1 -0.2
Vascular/heart problems diagnosed by doctor 0.9 2.5 14.5 0.0 -3.8 0.9 0.8 1.6 1.7 -1.8 -0.9 1.5 -0.4 0.0
Cholesterol lowering medication 1.0 1.4 6.8 0.3 1.6 -1.1 -1.0 -0.7 0.4 2.6 -0.6 -1.3 0.7 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 5.3 1.6 -0.5 -0.9 -1.1 0.9 1.9 0.4 2.3 0.6 1.1 -0.5
Pain experienced in last month 0.4 0.6 1.7 -0.9 0.1 -0.0 0.5 -1.0 -0.6 -0.2 -1.2 -0.6 -1.0 1.3
Supplements: Calcium 0.5 0.6 1.7 -1.3 -0.1 -1.0 -0.0 -0.1 0.1 -1.0 1.2 0.2 -1.2 -0.0
Basal cell carcinoma (self-reported) 1.6 1.9 7.7 -1.4 0.8 -2.8 -2.5 -0.9 -0.4 -0.4 0.9 -0.7 -1.1 -0.4
Heart attack/myocardial infarction (self-reported) 2.7 3.5 9.2 -2.4 0.2 -1.0 -1.3 -2.1 -2.8 -2.1 0.9 -0.0 -1.8 -3.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.2 -0.3 0.7 0.6 0.3 0.3 0.2 1.1 0.4 -1.1 -0.2 0.0
Heart disease (siblings) 0.4 0.5 1.5 -0.7 0.7 -0.2 -0.2 -0.9 -1.2 0.3 1.1 -0.7 -0.1 -0.9
Alcohol drinker status: Previous 0.2 0.2 0.5 0.7 0.3 -0.0 -0.4 0.1 0.4 0.2 -0.5 0.4 0.6 0.7
Pack years of smoking 1.3 2.0 4.7 1.6 0.9 -1.8 -0.5 0.6 1.2 2.2 -1.9 0.1 1.7 1.1
Impedance of whole body 1.6 8.0 36.1 0.7 -6.0 0.3 -0.1 3.2 2.2 -4.0 3.2 3.1 0.2 0.7
Leg fat mass (left) 1.8 6.9 14.7 3.7 0.6 -2.3 -1.9 3.3 2.9 3.8 -1.0 0.6 3.8 1.9
Arm predicted mass (left) 0.4 1.9 7.4 1.3 1.3 -0.5 0.0 1.9 0.6 2.7 -1.7 -0.8 1.5 -0.1