Hub : Genes

LINGO1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0450	0.0170	1.4e-04	0.043	0.022	0.038	0.022	0.039	5.6e-06	8.6e-04	1.7e-05	0.00092	1.3e-05
2	GTEx	Artery Tibial	0.0809	0.0384	3.6e-03	0.041	NA	0.021	NA	0.028	3.4e-04	NA	8.7e-03	NA	2.7e-03
3	GTEx	Brain Cerebellar Hemisphere	0.4440	0.1110	7.5e-04	0.109	NA	0.156	NA	0.237	9.8e-04	NA	8.2e-05	NA	9.2e-07
4	GTEx	Brain Cerebellum	0.2990	0.0920	1.1e-03	0.061	NA	0.155	NA	0.176	7.3e-03	NA	2.5e-05	NA	6.7e-06
5	GTEx	Brain Hypothalamus	0.1820	0.0680	1.9e-03	0.052	NA	0.075	NA	0.075	2.4e-02	NA	7.9e-03	NA	8.1e-03
6	GTEx	Lung	0.1039	0.0376	2.0e-04	0.091	NA	0.047	NA	0.076	1.9e-07	NA	1.6e-04	NA	2.0e-06
7	GTEx	Skin Sun Exposed Lower leg	0.0700	0.0340	4.6e-03	0.047	NA	0.072	NA	0.085	8.4e-05	NA	1.3e-06	NA	1.5e-07
8	GTEx	Testis	0.2040	0.0860	8.1e-03	0.118	NA	0.061	NA	0.086	6.5e-06	NA	1.1e-03	NA	1.1e-04
9	TCGA	Breast Invasive Carcinoma	0.0388	0.0148	4.1e-08	0.029	0.031	0.030	NA	0.026	9.5e-07	4.8e-07	8.0e-07	NA	4.0e-06
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0550	0.0300	7.9e-03	0.077	0.044	0.064	NA	0.067	3.3e-05	1.6e-03	1.6e-04	NA	1.1e-04
11	TCGA	Pancreatic Adenocarcinoma	0.1760	0.0770	3.2e-04	0.018	0.040	0.048	NA	0.059	5.6e-02	8.4e-03	4.2e-03	NA	1.7e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	3.0	4.7	15.6	-4.0	0.5	0.8	0.6	-2.2	-3.1	-1.1	0.0	-2.1	-3.7	-1.1
Bipolar Disorder or Schizophrenia	1.4	3.5	10.3	-3.1	0.7	-1.2	-0.7	-1.6	-2.3	-0.3	1.6	-2.3	-3.2	0.4
Depressed Affect (Nagel 2018)	1.4	2.9	26.2	0.2	0.7	-0.3	-1.7	-0.6	-0.6	-0.0	5.1	-0.4	-0.4	0.9
Depression (Nagel 2018)	0.7	1.1	10.7	-0.1	-0.5	0.2	-0.4	0.3	-0.1	0.2	3.3	-0.4	-0.4	-0.2
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.9	-0.6	2.2	-0.7	-0.8	-1.2	-0.3	2.1	-0.1	-1.9	-0.7	1.6
Neuroticism (Nagel 2018)	1.4	3.2	30.7	1.1	-0.0	1.1	-0.7	0.4	0.2	-0.3	5.5	0.5	0.9	0.7
Schizophrenia (2018)	0.8	1.6	5.0	-0.8	0.5	-2.2	-1.4	-0.2	-0.5	0.5	2.1	-1.3	-1.1	1.4
Schizophrenia vs Biploar Disorder	1.8	2.3	5.7	1.9	1.4	-1.6	-1.0	0.2	1.3	1.8	1.4	-0.9	1.7	2.4
Worry (Nagel 2018)	1.0	2.2	12.9	1.6	-0.6	1.1	0.2	1.4	1.3	0.3	3.6	0.7	1.5	0.6
Alzheimer’s Disease (in mother)	0.8	0.9	2.3	-0.8	0.7	-1.0	-1.4	-1.5	-0.3	0.5	-0.4	-0.8	-0.9	-1.3
Alzheimer’s Disease (in father)	1.3	1.4	3.7	-1.3	0.9	0.2	0.6	-1.6	-1.9	0.1	-1.5	-0.8	-1.7	0.2
Alzheimer’s Disease (including proxy)	0.4	0.6	1.9	-0.9	0.5	-0.1	0.3	-1.1	-0.8	-0.0	-0.9	-0.5	-1.0	-1.4
Crohns Disease (2017)	2.0	4.4	14.0	1.0	-3.3	-0.2	-0.5	3.7	1.5	-3.0	1.2	3.0	0.7	0.0
Irritable Bowel Disease (IBD)	1.7	4.0	8.7	0.9	-2.9	-0.1	-0.9	2.8	1.6	-2.7	2.7	2.9	0.5	0.2
Ulcerative Colitis (UC)	1.1	2.0	7.2	0.3	-2.0	0.1	-0.7	1.0	0.8	-2.1	2.7	2.1	0.1	0.0
Major Depression (MDD)	0.7	0.9	5.1	0.4	-0.4	-0.7	-1.1	1.0	0.4	-0.5	2.3	0.6	0.5	0.5
Reaction Time	0.4	0.8	2.7	0.2	1.1	-1.5	-1.6	-0.7	-0.3	0.4	1.2	0.3	0.1	0.3
Verbal and Numeric Reasoning (VNR)	1.0	2.5	5.0	-1.7	2.1	0.2	0.7	-1.6	-1.0	2.1	-1.8	-2.2	-1.7	0.7
Breast Cancer	0.5	1.3	3.6	-1.3	-1.0	0.3	-0.2	-0.3	-0.8	-1.6	1.9	0.3	-1.4	-1.5
Ovarian Cancer	0.5	0.6	2.8	-0.8	0.5	0.4	-0.4	-0.6	-0.4	-0.2	0.8	-0.3	-1.4	1.7
Prostate Cancer	1.7	2.4	5.3	-0.1	2.3	1.6	2.1	-1.1	-0.6	1.6	-1.3	-1.5	0.5	-2.3
Age at First Birth	0.3	0.5	2.3	-0.3	-0.7	0.3	-0.3	-0.6	-0.6	-1.5	0.5	0.4	0.3	-1.1
Bipolar Disorder (2011)	1.8	1.8	5.1	-2.1	0.7	0.0	0.5	-1.7	-2.3	-0.8	-0.6	-0.9	-2.1	0.3
Body Mass Index (BMI) (2010)	1.3	1.8	5.3	0.6	1.3	-2.3	-1.5	0.3	1.7	1.2	-1.7	-0.6	-0.1	1.6
Coronary Artery Disease (CAD)	1.2	1.4	3.7	-1.0	1.9	-0.3	-1.0	-1.8	-1.0	0.4	1.5	-1.2	-1.3	-0.5
Crohns Disease (2012)	1.4	2.3	5.4	0.7	-2.0	-1.0	-1.1	2.3	1.2	-2.3	1.0	2.1	-0.1	0.7
Mean Putamen Volume	0.4	0.5	1.3	0.6	0.4	-0.5	0.5	-0.2	-0.1	-1.1	0.5	1.1	0.7	0.9
Fasting Glucose	1.7	2.1	8.4	1.4	0.7	-1.4	-0.5	1.1	2.9	1.7	-0.4	0.3	2.2	0.6
HbA1C	2.1	2.3	8.1	-0.3	2.8	0.0	-0.3	-2.0	0.7	2.2	-1.6	-2.0	-1.0	0.6
HDL Cholesterol	0.3	0.5	1.4	-0.3	-1.2	0.8	0.7	0.8	-0.2	-0.9	-0.2	0.4	-0.0	-1.1
LDL Cholesterol	0.1	0.2	0.9	0.0	0.5	-0.8	-0.9	-0.1	0.0	-0.1	0.3	0.4	0.0	0.5
Lupus	1.5	2.3	9.4	0.8	-3.1	0.0	-0.1	2.6	1.4	-1.1	1.7	1.4	0.6	0.2
Neuroticism (2016)	1.3	1.9	15.1	0.9	0.7	-0.9	-1.7	0.2	0.6	-0.1	3.9	-0.2	0.4	0.4
Primary Biliary Cirrhosis	0.6	0.9	4.4	0.6	-2.1	-0.1	0.1	1.4	0.7	-0.8	0.7	1.1	0.7	0.1
Rheumatoid Arthritis	1.8	2.4	8.4	1.1	-2.6	0.0	-0.6	2.9	2.2	-0.5	1.3	1.1	1.4	0.1
Schizophrenia (2014)	1.1	2.4	7.4	-1.1	1.2	-2.1	-1.3	-0.9	-1.2	1.3	0.8	-2.0	-1.4	2.7
Triglycerides	0.4	0.7	2.4	-0.6	1.0	-1.1	-1.5	-1.0	-1.0	0.3	0.3	-0.6	-0.5	-0.5
Type 2 Diabetes (T2D) (2012)	2.3	2.7	6.9	2.2	1.6	0.3	0.6	0.6	1.8	2.6	-1.4	-0.1	2.5	1.7
Ulcerative Colitis	1.3	1.9	7.1	0.4	-1.6	-0.7	-1.4	0.8	0.7	-2.0	2.7	1.8	-0.1	-0.4
Blood Eosinophil Count	0.4	2.8	10.7	1.9	3.3	-1.3	-0.9	-0.6	0.8	2.3	-1.4	-0.4	1.9	1.3
Blood Platelet Count	0.4	4.7	22.6	0.2	2.4	-3.4	-4.8	-1.9	0.1	1.7	1.2	-0.9	0.6	1.5
Blood Red Count	1.4	13.2	38.6	1.1	6.2	-4.9	-4.2	-2.4	1.1	4.8	-2.2	-2.9	0.8	4.3
Blood White Count	1.3	9.5	29.7	0.3	5.5	-3.8	-4.2	-3.4	-0.6	4.3	-2.3	-2.5	0.5	0.9
Heel T-Score	1.0	8.3	21.6	3.2	-4.7	-0.1	-0.9	4.2	2.4	-2.0	1.4	4.2	3.5	0.1
BMI	0.8	4.7	20.9	1.7	2.9	-1.5	-2.0	0.0	1.0	4.6	-2.6	-1.2	2.0	0.8
Height	1.4	26.4	118.8	0.5	-10.9	1.4	1.5	8.5	1.4	-7.0	3.3	5.6	0.3	-1.9
Waist Hip Ratio (WHR)	0.7	3.0	9.4	-0.3	1.8	-1.5	-1.3	-1.2	-0.5	3.0	1.2	-1.9	-0.5	3.1
Systolic Blood Pressure	0.4	2.0	7.6	-0.6	2.2	0.6	0.7	-0.7	-0.7	1.7	-2.8	-2.1	-0.1	-0.1
Smoking Status	2.2	5.3	12.5	-1.2	2.6	-3.5	-3.5	-2.6	-1.7	2.3	0.3	-2.7	-1.5	-0.5
Allergy or Eczema	0.8	2.2	9.3	-1.6	-0.8	-0.6	-0.4	-0.9	-1.6	-2.6	0.7	-0.1	-1.1	-3.0
Cardiovascular Disease	1.2	4.1	19.5	0.0	4.4	-0.5	-0.6	-2.0	-1.0	3.4	-0.0	-2.6	0.1	1.3
Hypothyroidism (self reported)	0.2	0.5	1.3	0.7	-0.9	-0.2	0.0	0.6	0.5	-0.2	0.9	1.1	0.8	-0.8
Respiratory disease	0.6	1.3	5.1	0.4	-0.8	-2.3	-2.0	1.2	0.6	-0.3	1.1	0.8	0.4	0.5
Type 2 Diabetes (T2D) (2018)	3.5	6.5	17.5	3.9	2.6	0.0	-0.9	1.8	3.8	3.6	0.1	0.3	4.2	0.9
Lung FEV1/FVC ratio	2.6	13.2	36.2	-3.4	6.0	1.8	2.5	-5.6	-3.3	2.6	-3.2	-4.2	-3.1	-0.6
Lung FVC	0.7	3.3	7.7	-2.5	0.9	0.4	0.9	-2.7	-2.8	-0.6	-0.4	-1.9	-2.6	-1.7
Neuroticism	2.1	5.0	26.2	2.8	-0.3	1.1	-0.1	1.7	1.8	0.9	5.1	1.0	3.0	1.6
Chronotype (morning person)	1.2	2.7	11.2	1.3	-1.6	0.8	1.1	2.0	2.2	-0.6	-3.3	1.3	1.1	-0.2
Hair Pigment	0.1	3.7	13.5	2.0	-3.0	1.1	1.3	3.7	1.0	-0.4	0.6	1.8	2.4	0.3
Tanning	0.2	1.9	5.6	-2.4	0.2	-0.3	0.6	-0.9	-2.0	-0.8	-1.1	-1.4	-2.3	-0.4
Hand grip strength (left)	2.1	5.4	22.5	-2.8	-2.0	1.1	1.4	0.5	-2.4	-2.3	-4.7	-0.7	-2.5	-2.0
Number of treatments/medications taken	1.8	3.2	9.6	0.3	1.8	-2.3	-3.1	-0.4	-0.2	2.1	3.0	-1.5	0.2	-0.9
Average weekly spirits intake	0.9	1.1	6.5	-0.6	-0.9	-1.1	-2.5	-0.2	-0.5	0.5	1.3	-0.4	-0.7	-0.1
Sensitivity / hurt feelings	1.0	1.7	5.3	1.7	-0.9	0.8	0.6	1.1	1.4	1.3	2.3	0.1	2.0	-0.5
Frequency of depressed mood in last 2 weeks	0.9	1.3	6.0	1.2	-0.9	-0.0	-0.2	1.5	1.5	1.0	2.5	0.0	0.8	0.2
Hearing difficulty/problems: Yes	1.5	2.3	6.3	-1.8	0.2	-1.6	-2.5	-1.4	-1.6	-0.2	1.6	-0.9	-2.2	0.6
Relative age of first facial hair	2.2	4.6	10.6	-2.1	2.0	2.1	2.3	-3.2	-3.0	0.3	-1.7	-1.8	-1.8	-1.7
Other serious medical condition/disability diagnosed by doctor	2.6	3.3	7.2	-2.3	1.4	-0.9	-0.9	-2.7	-2.7	0.7	1.5	-2.1	-1.9	-1.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	3.1	0.5	1.0	-0.9	-0.9	-0.2	0.3	1.3	1.8	-0.4	0.8	0.7
Ever had hysterectomy (womb removed)	0.9	1.0	2.2	1.4	0.3	-1.0	-0.6	0.7	1.2	-0.1	1.2	1.1	1.5	0.8
Systolic blood pressure, automated reading	0.2	0.5	1.5	-0.4	1.1	0.2	0.1	-0.0	-0.9	0.5	-1.2	-0.8	0.2	-0.8
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	4.5	1.3	0.1	-2.1	-2.1	0.7	1.8	-0.2	0.1	0.8	1.4	-0.6
Angina	0.5	0.7	2.1	-1.0	0.4	-1.1	-0.9	-0.8	-0.8	0.8	0.7	-1.4	-0.2	-0.6
Medication for hormone replacement therapy	0.8	0.9	3.3	1.5	1.8	-0.9	-0.3	-0.3	0.7	0.4	0.3	-0.0	1.1	1.2
Vitamin and mineral supplements	1.9	2.5	7.3	1.5	-2.3	-0.9	-1.5	1.1	1.2	-1.0	1.2	2.7	2.2	0.0
Supplements: Zinc	0.8	0.8	2.8	0.6	0.6	1.2	1.7	0.9	1.5	0.7	0.1	-0.3	0.5	0.6
Medication: Co-codamol	1.8	2.1	5.4	1.7	-2.3	-0.0	-0.1	1.8	1.6	-1.3	0.9	2.3	1.3	-0.2
Medication: Metformin	2.6	3.7	10.1	2.8	1.6	0.5	-0.8	1.1	2.8	3.0	0.4	0.5	3.2	0.6
Diabetes (father)	0.3	0.3	1.7	-0.1	0.3	-0.3	-0.3	0.1	0.2	0.8	0.1	-0.9	0.2	-1.3
Diabetes (mother)	2.0	2.6	7.8	1.7	0.8	-0.9	-2.8	-0.0	1.3	1.1	2.2	0.4	1.2	2.6
Severe depression (siblings)	0.2	0.2	1.0	-0.1	-0.6	0.5	0.3	0.6	0.1	-0.2	1.0	0.2	0.6	-0.5
Pack years adult smoking proportion	1.3	1.9	4.5	1.7	0.7	-1.7	-0.5	0.7	1.4	2.1	-1.9	0.2	1.7	1.0
Impedance of leg (right)	2.3	10.9	35.5	2.3	-6.0	1.2	0.9	4.7	3.6	-3.0	3.5	3.7	1.8	2.2
Leg fat-free mass (left)	0.3	1.4	5.3	0.6	1.2	-1.3	-0.9	1.0	-0.1	2.3	-1.8	-0.9	0.8	-0.4
Trunk fat percentage	1.8	7.2	15.1	3.9	-1.2	-2.6	-2.6	3.7	3.3	2.3	0.0	1.8	3.9	1.1
Hand grip strength (right)	2.4	6.5	20.6	-2.4	-2.6	2.4	3.0	1.2	-2.5	-2.7	-4.5	-0.3	-1.7	-2.2
Townsend deprivation index at recruitment	2.4	3.3	8.0	1.4	1.5	-2.5	-2.7	-0.1	1.6	2.8	1.2	-1.6	0.4	2.0
Current tobacco smoking	1.5	2.4	6.9	1.0	1.6	-2.4	-2.6	-0.7	0.5	2.5	1.1	-1.1	0.8	0.5
Average weekly fortified wine intake	2.4	2.8	8.8	1.6	-2.3	-0.4	-0.9	2.3	0.7	-2.2	1.2	3.0	1.2	-0.2
Maternal smoking around birth	1.9	2.8	7.6	1.9	2.0	-1.1	-1.2	0.4	0.5	2.6	-1.3	-1.1	1.6	2.8
Fed-up feelings	1.3	2.3	17.2	1.1	0.3	-0.8	-2.2	0.4	0.5	0.4	4.2	0.5	0.7	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	10.7	0.8	-1.1	-0.1	-0.9	0.8	0.5	-0.4	3.3	0.6	0.4	-0.0
Relative age voice broke	0.3	0.5	1.3	0.1	0.7	0.9	1.1	-0.7	-0.5	-0.6	-0.6	0.2	0.0	-1.0
Taking other prescription medications	1.4	2.1	5.3	2.1	0.4	-0.2	-0.5	1.9	1.6	1.9	2.3	0.3	1.6	-0.1
Age when periods started (menarche)	2.0	4.7	13.5	-2.5	-2.8	1.3	0.3	-0.4	-2.7	-3.7	2.7	-0.1	-2.7	-0.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.0	1.4	0.5	1.2	1.7	0.6	0.8	1.5	0.5	0.1	1.2	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	5.8	2.3	-1.8	0.8	0.2	2.0	1.7	-0.5	0.1	2.4	2.1	0.7
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.5	-0.7	0.4	1.6	1.5	-0.2	0.6	1.1	0.8	-1.4	-0.7	-0.2
Qualifications: CSEs or equivalent	0.2	0.3	1.0	1.0	-0.3	-0.4	-0.0	0.4	1.0	-0.0	0.1	0.7	0.4	0.5
Serious illness, injury or assault to yourself	0.5	0.6	3.7	0.0	0.1	-0.8	-1.2	-0.3	-0.0	0.2	-0.4	0.0	-0.2	-1.9
High blood pressure	1.1	3.0	18.4	0.4	4.3	-0.6	-0.6	-1.7	-1.4	2.4	0.7	-1.7	0.6	0.6
Hayfever, allergic rhinitis or eczema	1.0	2.2	7.1	-1.9	0.4	-0.7	-0.6	-1.9	-1.9	-1.1	1.0	-1.1	-1.6	-2.7
Multivitamins +/- minerals	1.2	1.5	4.3	-0.6	2.1	0.2	0.7	-1.4	-0.7	1.1	-1.7	-2.0	-1.1	-0.4
Stomach or abdominal pain in last month	0.4	0.5	1.4	-0.7	-0.2	-0.7	-1.2	0.2	-0.7	0.9	0.5	-1.1	-0.6	-0.5
Supplements: Glucosamine	1.2	1.6	3.3	-1.8	0.6	1.5	1.8	-0.6	-1.0	-0.6	1.2	-0.8	-1.7	-1.4
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	5.7	-0.6	-1.2	-0.9	-0.8	0.3	-0.6	0.0	2.4	-0.2	-0.8	-0.8
Medication: Atenolol	0.6	0.7	1.6	-0.8	0.6	-1.1	-1.1	-1.3	-1.1	-0.3	1.1	-0.2	-0.3	-0.4
Medication: Levothyroxine sodium	0.3	0.6	4.3	0.1	0.5	0.0	-0.1	-1.0	-0.3	0.8	2.1	0.0	-0.3	-0.3
Sitting height	0.2	1.6	3.8	-1.9	-0.3	-1.9	-1.5	-0.2	-1.9	-1.2	0.1	-0.3	-1.6	-0.3
Chronic bronchitis/emphysema (father)	0.9	1.1	4.8	0.6	0.2	-1.7	-2.2	0.4	1.3	0.9	0.0	0.0	0.8	-0.4
High blood pressure (mother)	1.4	2.0	6.9	-0.7	2.6	-1.2	-1.1	-1.9	-0.4	1.3	-1.7	-1.1	-0.8	1.4
Body mass index (BMI)	1.7	7.1	24.6	3.3	2.8	-2.4	-2.5	1.1	1.9	5.0	-1.8	-0.4	3.5	1.5
Impedance of leg (left)	2.2	10.8	39.3	1.9	-6.3	0.9	0.9	4.5	3.2	-3.6	3.6	3.7	1.5	1.5
Leg predicted mass (left)	0.3	1.4	5.3	0.5	1.3	-1.3	-0.9	0.9	-0.2	2.3	-1.8	-1.0	0.6	-0.5
Trunk fat mass	1.4	6.1	13.6	3.5	-0.9	-2.5	-2.3	3.7	2.8	2.4	-0.4	1.4	3.5	0.9
Waist circumference	1.5	5.7	19.6	3.1	1.5	-2.2	-2.2	1.9	2.0	4.4	-0.8	0.0	3.1	1.9
Number of incorrect matches in round	0.5	0.9	4.3	0.5	1.4	0.1	0.5	-0.2	0.8	2.1	-0.8	-0.8	0.9	0.2
Past tobacco smoking	2.0	3.8	7.6	2.6	-0.8	2.0	1.5	2.3	2.6	-0.3	-0.3	2.8	2.4	1.4
Alcohol usually taken with meals	0.7	1.1	5.4	0.3	-0.4	1.7	2.3	0.8	0.6	-0.3	-0.7	0.4	-0.4	1.4
Nervous feelings	1.2	2.3	15.6	1.4	-1.2	0.6	0.4	1.3	0.8	0.1	4.0	0.8	1.5	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	6.1	1.4	1.0	0.4	0.1	0.3	1.4	2.5	1.7	-1.0	0.8	-0.0
Hearing difficulty/problems with background noise	0.6	0.9	3.2	-0.6	1.2	-1.0	-1.4	-0.4	-0.4	0.5	1.8	-0.8	-1.0	0.1
Hair/balding pattern: Pattern 2	1.1	1.3	2.7	-0.9	1.7	1.2	1.3	-1.5	-1.2	0.2	0.7	-1.2	-0.6	-1.4
Had menopause	0.9	1.1	3.0	-0.2	1.5	-1.2	-1.4	-1.7	-0.6	0.6	1.5	-0.1	0.4	-0.5
Had other major operations	0.1	0.2	0.5	0.4	0.7	0.5	0.6	0.1	0.1	0.5	-0.1	0.0	0.2	-0.3
Forced vital capacity (FVC)	0.9	3.6	8.5	-2.9	-2.0	0.7	1.2	-0.5	-2.5	-2.5	-0.6	-1.1	-2.9	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	12.0	2.4	-2.5	0.7	-0.2	3.5	2.3	-0.8	0.9	2.9	2.5	0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.9	1.1	-0.1	-0.3	-0.6	0.9	1.0	-0.0	1.4	1.2	0.7	0.3
Qualifications: None of the above	0.6	1.3	6.8	0.5	-0.3	-1.8	-2.6	0.5	0.4	0.2	1.7	-0.6	0.2	0.1
Financial difficulties in last 2 years	1.1	1.5	4.2	2.1	0.4	1.3	0.9	1.7	1.6	1.0	-0.0	0.4	1.6	0.6
Mouth/teeth dental problems	0.5	0.8	2.0	-0.4	1.2	1.1	1.3	-1.4	-0.4	0.3	-1.1	-0.3	-0.8	-0.2
Heart attack	2.5	3.1	7.6	-2.4	0.2	-1.0	-1.4	-2.0	-2.6	-1.9	0.8	-0.2	-1.8	-2.7
Allergy	0.4	1.0	1.7	1.3	-0.2	1.1	0.9	0.9	1.3	0.6	-1.2	0.8	1.2	1.1
Pain all over the body in last month	1.0	1.0	4.2	1.2	-0.4	-0.7	-0.3	1.1	1.5	0.7	2.0	0.4	0.8	-0.8
Diabetes (self-reported)	2.2	3.4	9.0	2.9	1.5	-0.0	-0.4	1.4	2.3	3.0	-0.1	0.3	3.0	0.9
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	9.8	-0.8	-3.1	-0.3	-0.9	1.4	-0.4	-1.9	2.9	0.8	-0.5	0.1
Medication: Ramipril	0.2	0.3	1.2	0.3	0.5	-0.3	-0.5	0.3	-0.6	0.9	-0.5	-0.3	1.1	-0.2
Medication: Simvastatin	0.9	1.3	4.1	-0.8	2.0	-1.1	-1.0	-1.2	-0.6	1.7	0.8	-1.3	-0.2	-0.3
Fluid intelligence score	1.4	2.9	8.7	-0.5	2.6	-0.8	-0.2	-1.6	0.2	3.0	-2.2	-2.3	-0.7	1.6
Illnesses of siblings	1.4	2.0	6.6	-1.0	-1.9	2.4	2.6	0.3	-0.2	-1.1	-0.8	0.2	-1.4	0.8
Neuroticism score	2.8	5.7	26.5	3.3	-0.9	0.9	-0.2	2.3	2.0	0.7	5.2	1.5	3.3	1.2
Weight	0.9	4.5	9.1	2.9	0.1	-2.3	-2.1	3.0	2.0	2.7	-0.7	0.8	3.0	0.9
Impedance of arm (right)	1.3	6.2	22.9	-0.6	-4.8	-1.1	-1.7	1.6	0.9	-4.4	3.1	2.4	-1.5	0.4
Arm fat percentage (right)	1.4	5.3	11.0	3.0	1.2	-2.9	-3.0	1.8	2.3	3.3	-1.4	0.4	2.8	1.4
Trunk fat-free mass	0.1	0.6	2.3	0.1	0.5	-0.5	0.0	1.5	-0.5	0.9	-1.4	-0.6	0.2	-0.3
Hip circumference	1.5	6.3	14.9	3.6	-1.4	-1.9	-2.1	3.9	3.0	2.2	-1.2	1.9	3.3	1.2
Time employed in main current job	1.2	1.3	6.9	-1.8	0.5	-0.6	-0.7	-1.3	-2.6	-0.4	0.3	-0.4	-1.2	-0.5
Alcohol intake versus 10 years previously	2.3	3.4	10.8	1.6	-2.2	-0.8	-0.8	3.3	2.1	-2.1	0.2	2.7	1.1	-0.4
Father’s age at death	0.7	1.0	2.2	-1.4	-0.1	1.5	1.1	-0.3	-0.7	-1.0	-0.3	-0.6	-1.1	-1.4
Worrier / anxious feelings	2.3	4.4	24.6	2.2	-1.2	0.6	-0.9	2.0	1.9	0.1	5.0	1.2	1.8	1.9
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.4	12.8	2.0	-1.3	-0.8	-1.8	2.0	2.5	1.0	3.6	1.0	1.5	0.7
Falls in the last year	1.2	1.6	4.4	-1.2	0.5	-0.3	-0.9	-1.1	-1.5	0.2	2.1	-1.0	-1.4	-1.9
Hair/balding pattern: Pattern 3	0.6	0.9	3.4	0.4	-1.7	0.3	0.4	0.6	0.3	-1.0	0.5	1.0	-0.2	1.8
Number of live births	0.4	0.6	2.0	0.5	-1.1	0.0	0.4	0.9	0.2	-1.4	0.3	1.2	0.4	-0.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	8.1	-2.8	-0.7	1.1	1.6	-1.2	-2.7	-1.6	-1.6	-1.5	-2.8	-1.6
Pulse rate	0.5	0.8	2.4	1.6	1.1	-0.7	0.1	0.2	0.7	1.1	-0.7	0.1	1.5	0.4
Happiness	0.9	1.1	4.0	1.0	-0.0	-2.0	-1.7	-0.1	0.3	-0.1	1.5	0.6	1.0	0.2
Noisy workplace	0.6	0.7	3.0	-0.0	-0.2	0.0	-0.3	-0.2	-1.2	-1.2	1.7	1.2	-0.0	-0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.8	3.3	-0.4	-1.2	-0.7	0.5	0.4	0.3	-1.1	-1.8	0.4	-0.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	8.8	0.0	3.0	1.0	1.4	-2.1	-0.5	2.1	-1.1	-1.9	-0.6	-0.3
Mouth/teeth dental problems: Dentures	0.6	1.1	3.4	0.1	-1.0	-0.6	-1.2	1.4	-0.5	-1.2	0.6	0.6	1.1	-1.8
Asthma	0.7	1.3	4.9	1.2	-1.6	-0.6	0.1	2.2	1.4	-0.1	0.9	0.8	1.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	3.8	0.7	0.1	0.6	0.1	0.2	0.7	1.9	-0.0	-0.9	0.2	0.0
Medication: Cholesterol lowering	0.6	0.9	4.2	-0.8	1.5	-0.3	-0.4	-0.9	-1.3	0.1	2.1	-0.3	-0.1	-0.4
Depression (self-reported)	0.6	0.7	2.2	-0.9	-1.1	0.8	-0.1	0.2	-0.4	-0.1	1.3	-0.9	-1.5	-0.5
Medication: Lansoprazole	1.1	1.2	5.7	1.2	0.9	-0.4	-1.1	0.5	1.4	2.4	0.4	-0.4	1.3	-0.2
Prospective memory result	1.4	1.7	4.5	1.3	0.1	-1.7	-2.0	0.6	0.6	0.4	1.8	0.5	1.0	2.1
Lung cancer (father)	2.3	2.7	8.0	2.8	-0.1	-0.1	-0.2	1.1	2.8	1.4	-1.0	1.5	2.4	1.5
Illnesses of mother	4.2	5.1	23.2	0.2	-3.0	3.5	4.8	1.8	-0.4	-2.1	-0.6	1.1	0.7	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	6.0	-2.3	-1.2	0.6	0.6	-0.8	-2.3	-1.9	-0.4	-0.6	-2.4	-1.9
Pulse wave Arterial Stiffness index	1.4	1.7	5.9	-0.2	2.4	-1.7	-1.1	-1.9	-1.4	1.0	0.5	-1.4	-0.1	-0.1
Impedance of arm (left)	1.7	7.7	33.2	-0.2	-5.8	-0.9	-1.3	2.1	1.1	-4.9	3.1	3.1	-0.8	0.1
Arm fat mass (right)	1.3	5.5	13.1	2.9	1.1	-2.8	-2.7	2.3	2.1	3.6	-1.5	0.2	3.0	1.3
Trunk predicted mass	0.1	0.6	2.0	-0.1	0.5	-0.5	-0.0	1.4	-0.6	0.9	-1.4	-0.6	0.0	-0.3
Standing height	0.8	7.7	33.5	-0.5	-5.8	-0.1	0.5	4.5	0.3	-4.2	2.3	2.4	-0.5	-1.1
Length of working week for main job	3.9	4.4	11.9	3.4	-1.0	0.4	0.6	2.9	2.4	-0.2	0.5	2.6	3.4	1.3
Exposure to tobacco smoke at home	1.1	1.2	2.8	1.4	-1.3	0.6	-0.6	0.5	0.7	-0.4	1.7	1.4	1.7	0.3
Breastfed as a baby	1.8	2.3	5.4	-2.0	0.7	2.0	1.9	-1.5	-2.3	-0.9	0.1	-0.3	-1.8	-1.0
Tense / ‘highly strung’	0.6	1.0	4.4	1.0	0.4	0.1	0.1	0.3	0.6	1.6	2.1	-0.8	1.0	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	4.1	-0.0	-0.8	1.6	0.7	0.2	-0.5	-0.7	2.0	-0.1	0.1	-0.6
Hair/balding pattern: Pattern 4	0.5	1.2	4.8	-0.2	0.4	-1.8	-2.2	0.8	0.3	1.5	0.1	-0.8	0.0	1.2
Birth weight of first child	0.4	0.7	2.6	-1.3	0.6	-1.0	-1.6	-0.2	-0.6	0.5	0.5	-0.6	-1.1	0.0
Peak expiratory flow (PEF)	2.7	6.2	15.1	-3.9	-0.3	0.6	1.3	-1.9	-3.9	-1.9	-2.8	-1.9	-3.4	-2.4
Pulse wave reflection index	0.2	0.3	0.5	0.1	0.5	-0.6	0.0	-0.7	-0.4	0.7	0.6	-0.7	0.1	0.5
Ever highly irritable/argumentative for 2 days	1.7	2.0	7.2	0.9	0.8	-2.7	-2.6	0.8	1.4	1.1	-0.6	0.5	0.9	1.3
Loud music exposure frequency	0.6	0.7	4.1	0.3	0.2	1.2	0.6	0.0	0.8	0.5	-2.0	0.1	0.5	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.9	0.3	-0.3	0.9	0.9	-0.5	0.2	0.4	-0.8	-0.0	0.3	-0.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.6	1.8	0.5	-1.1	0.2	0.6	0.8	1.1	-0.1	-0.3	0.7	0.3	1.3
Blood clot in the leg (DVT)	0.3	0.3	1.2	-0.1	0.6	0.6	0.2	0.3	0.2	1.1	0.8	-1.0	-0.0	-0.1
Medication: Paracetamol	1.5	2.5	7.3	1.7	-0.9	-1.0	-2.1	2.0	2.1	0.5	2.7	0.6	1.0	-0.5
Headache pain in last month	0.9	1.5	4.5	2.1	-0.5	-0.0	-0.7	1.7	1.8	1.1	-0.1	0.6	1.8	0.6
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.7	1.1	-2.2	1.0	1.1	1.1	1.5	-1.1	-1.6	1.2	0.7	0.3
Glaucoma (self-reported)	0.3	0.3	0.7	-0.5	0.2	-0.8	-0.7	-0.2	-0.8	0.1	0.8	-0.3	0.2	0.8
Gout (self-reported)	0.5	0.6	2.6	-0.4	0.4	-1.6	-0.6	0.4	-0.7	-0.3	-0.4	-0.1	-1.1	-1.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.1	0.3	0.0	-0.3	-0.1	-0.2	-0.1	0.1	1.0	0.9	0.2	-0.9
Medication: Amlodipine	1.3	1.9	5.5	-1.0	2.3	-0.1	0.0	-1.9	-2.1	-0.1	-0.5	-0.9	-0.8	-2.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.6	0.0	-0.1	0.2	-0.3	0.4	0.5	0.1	0.5	0.1	0.8	0.3
Birth weight	1.2	2.6	6.6	-2.4	-2.1	-0.1	-0.9	-0.2	-2.3	-2.6	-0.5	0.1	-1.6	-1.6
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.0	1.8	-0.2	-0.4	-0.4	1.5	2.0	1.4	-0.9	-0.0	0.9	1.4
High blood pressure (siblings)	0.9	1.2	4.6	0.1	2.2	-1.4	-1.4	-1.0	-1.0	0.8	0.2	-0.7	0.5	-1.2
Forced vital capacity (FVC), Best measure	0.7	2.7	8.2	-1.9	-2.9	0.3	0.2	0.4	-1.7	-2.7	0.8	0.1	-2.1	-1.5
Body fat percentage	2.0	7.7	16.8	4.1	-0.5	-2.6	-2.5	3.6	3.4	3.0	-0.4	1.5	4.1	1.4
Leg fat percentage (right)	2.9	10.7	24.7	5.0	0.0	-1.9	-1.9	3.9	4.3	3.9	-0.1	1.6	5.0	3.1
Arm fat-free mass (right)	0.3	1.4	4.5	0.9	0.8	-0.3	0.4	1.9	0.1	2.1	-1.8	-0.5	1.5	-0.3
Exposure to tobacco smoke outside home	1.2	1.6	4.5	1.6	-0.7	1.0	-0.4	2.1	1.5	0.6	-0.7	0.8	2.0	1.1
Comparative body size at age 10	0.4	1.1	2.1	-1.3	0.6	-1.4	-1.4	-0.8	-1.0	0.9	-1.2	-1.1	-0.8	0.2
Number of full brothers	0.9	1.1	3.1	1.8	0.1	-0.0	0.2	1.5	1.5	0.6	-0.9	1.0	1.7	-0.0
Worry too long after embarrassment	3.8	6.4	15.3	3.4	-0.8	2.4	1.3	2.6	2.7	1.5	3.6	1.9	3.9	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	10.8	-1.5	-0.5	-0.5	-1.3	-0.8	-1.8	-0.7	3.3	-1.2	-2.6	-0.4
Wheeze or whistling in the chest in last year	0.6	1.0	2.5	0.6	-0.8	-1.1	-1.6	1.5	1.3	0.7	0.9	0.1	0.7	0.7
Number of children fathered	0.5	0.5	2.0	-0.8	-0.0	-0.1	-1.0	-0.2	-0.3	-1.4	0.3	0.5	-0.7	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.6	-0.6	0.2	1.1	1.3	0.1	-0.1	0.8	-0.8	-1.2	0.0	0.6
Age at first live birth	0.9	1.6	4.2	-2.0	-1.0	1.2	1.2	-0.4	-1.6	-1.0	0.1	-0.8	-1.9	-1.4
Pulse wave peak to peak time	1.9	2.2	7.8	0.2	-2.8	1.9	1.4	2.3	1.5	-1.1	-0.4	1.5	0.1	-0.0
Health satisfaction	1.1	1.5	4.1	2.0	0.7	-1.4	-0.8	0.2	0.8	2.0	0.8	0.4	1.7	0.7
Shortness of breath walking on level ground	0.7	0.8	2.5	1.1	0.1	-1.0	-1.0	0.6	0.4	1.6	-0.3	-0.3	1.5	0.4
Qualifications: College or University degree	0.3	0.9	5.2	-0.2	-0.2	-0.5	-0.2	-0.4	0.4	-0.4	1.8	0.1	-0.7	2.3
Eye problems/disorders: None of the above	0.3	0.4	1.1	0.2	0.9	0.4	1.0	0.4	0.6	0.4	-0.8	-0.4	-0.2	-0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	0.1	0.1	0.0	-0.1	-0.2	-0.1	0.2	0.6	-0.3	-0.0	0.7
Emphysema/chronic bronchitis	1.1	1.3	4.9	-0.2	0.7	-0.9	-0.9	-0.2	0.2	1.6	-1.4	-1.4	-0.6	2.2
Medication for pain relief, constipation, heartburn	0.9	1.5	4.7	-1.0	-1.5	0.5	1.2	-0.0	-0.8	-2.2	-1.7	1.1	-0.5	1.2
Neck or shoulder pain in last month	1.0	1.4	4.2	-0.0	2.0	-1.0	-1.3	-0.9	-1.0	1.3	-0.4	-0.9	0.4	-2.1
Medication: Blood pressure	1.2	2.2	7.0	-1.5	2.6	-1.2	-1.4	-1.6	-1.7	0.7	0.6	-1.7	-1.1	-1.0
Angina (self-reported)	0.7	0.9	2.4	-1.0	0.5	-1.2	-1.1	-1.0	-0.8	0.9	0.6	-1.5	-0.3	-0.5
Migraine (self-reported)	0.5	0.6	2.1	1.0	0.5	-0.5	-0.5	0.1	0.8	0.9	-0.1	-0.1	1.1	1.4
Medication: Ibuprofen	0.9	1.0	5.2	1.1	0.2	1.0	0.3	0.6	1.3	2.3	0.4	-1.0	0.7	-0.4
Medication: Allopurinol	0.4	0.5	3.5	-0.0	0.5	-0.1	0.7	-0.1	-0.8	-0.3	-0.8	0.2	-0.5	-1.9
Medication: Omeprazole	1.4	1.7	6.5	1.6	-0.7	-1.3	-1.3	0.7	1.6	-0.0	2.5	1.2	1.0	-0.3
Medication: Seretide 50 evohaler	1.6	1.8	4.4	-1.5	2.1	-1.4	-0.9	-1.4	-1.1	0.8	-0.3	-1.9	-1.4	0.9
Mean time to correctly identify matches	1.0	1.9	4.8	-0.4	1.9	-2.0	-2.0	-1.6	-1.2	0.5	2.2	-0.4	-0.2	0.1
Heart disease (mother)	1.3	1.6	6.4	0.5	0.6	-2.1	-2.5	-0.3	-0.1	0.9	2.0	0.3	0.6	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	8.3	-2.5	-1.0	0.9	1.4	-0.3	-2.9	-1.4	-1.5	-0.9	-1.5	-1.6
Whole body fat mass	1.5	6.3	12.9	3.5	-0.1	-2.6	-2.3	3.4	2.7	3.2	-0.7	0.9	3.6	1.3
Leg fat mass (right)	1.9	7.3	14.9	3.8	0.5	-2.2	-2.0	3.4	3.1	3.8	-0.9	0.7	3.9	2.2
Arm predicted mass (right)	0.3	1.7	5.7	1.1	0.8	0.1	0.8	2.1	0.4	2.4	-1.8	-0.6	1.6	-0.1
Pulse rate, automated reading	0.9	2.8	10.2	-0.4	3.2	-0.9	-0.5	-2.6	-0.7	2.0	-0.8	-2.2	-0.8	-1.4
Alcohol intake frequency.	4.5	10.4	25.0	4.5	-2.6	-0.7	-1.8	4.2	4.9	-1.6	0.9	5.0	3.7	0.6
Comparative height size at age 10	0.6	3.4	14.4	0.5	-3.8	-1.3	-1.6	2.9	1.1	-1.4	2.0	1.7	0.4	0.2
Number of full sisters	2.3	2.8	11.4	2.7	0.3	-0.0	-0.1	2.1	3.4	1.1	-1.6	0.7	1.6	1.1
Suffer from ‘nerves’	1.6	2.6	14.9	1.4	-1.6	1.6	1.0	1.8	0.9	-0.1	3.9	0.4	1.1	-0.2
Overall health rating	1.9	4.0	16.3	0.5	0.8	-3.1	-4.0	-0.3	0.0	2.2	3.4	-0.5	0.5	0.1
Chest pain or discomfort	0.4	0.5	1.6	-0.3	-0.0	-0.3	-0.7	-0.2	0.2	0.9	1.2	-1.0	-0.3	-1.3
Had major operations	0.5	0.6	1.2	1.0	-0.8	1.1	1.1	1.0	0.4	0.5	-0.2	0.4	1.0	0.0
Age at last live birth	1.0	1.4	4.6	0.5	-2.2	1.4	1.3	1.2	0.3	-1.1	-0.2	0.9	0.9	-1.5
Family relationship satisfaction	0.7	0.9	2.0	1.0	0.8	-1.2	-1.0	-0.1	0.9	0.8	-1.2	0.3	1.0	1.4
Leg pain on walking	0.7	0.9	4.9	-0.7	-0.1	0.0	0.1	-0.3	-1.1	-0.8	1.2	-0.5	-0.7	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.0	1.1	-0.1	-0.1	0.3	1.3	0.7	-0.1	-0.5	1.0	1.4	0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	4.0	0.2	-0.4	1.0	2.0	0.3	0.4	0.1	-0.9	-0.1	-0.1	0.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	4.6	-0.7	-2.2	-0.8	-0.7	0.8	-0.7	-1.4	0.4	1.0	0.5	0.8
Medication: Aspirin	3.4	4.4	9.4	-2.4	3.0	-0.9	-1.2	-3.1	-2.4	1.6	0.9	-2.9	-1.7	-1.4
Supplements: Vitamin C	0.5	0.6	2.3	-0.5	0.5	1.3	1.5	-0.0	-0.3	-0.0	-0.4	-0.5	-0.9	0.5
Knee pain experienced in last month	0.4	0.6	1.7	-0.5	0.2	0.9	1.2	-0.3	-0.4	-0.9	1.1	0.1	-0.1	-1.3
Hypertension (Self-reported)	1.0	2.9	16.8	-0.1	4.1	-0.6	-0.8	-1.8	-1.7	2.0	0.6	-1.8	0.3	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.8	1.7	0.9	-0.4	-0.4	0.3	0.7	2.0	0.1	-0.4	1.5	0.3
Illnesses of father: Heart disease	1.7	2.4	5.9	-1.6	2.4	1.1	1.3	-2.4	-1.4	0.9	0.1	-1.7	-1.9	0.1
Illnesses of siblings: Diabetes	1.5	1.9	5.2	1.7	1.3	-2.0	-2.3	0.4	1.7	0.9	-0.0	0.6	1.6	-0.3
Smoking status: Previous	1.8	2.7	6.9	-2.5	0.7	-1.4	-0.7	-2.0	-2.6	-0.7	0.4	-1.7	-2.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	-0.8	-0.8	0.7	1.2	-0.7	-1.3	-1.3	0.3	0.4	-0.9	-1.0
Whole body fat-free mass	0.2	1.0	3.1	0.3	0.9	-0.7	-0.2	1.3	-0.3	1.7	-1.8	-0.8	0.5	-0.5
Leg fat-free mass (right)	0.2	1.3	3.8	0.1	1.2	-1.4	-0.8	0.6	-0.6	1.9	-1.9	-1.1	0.3	-0.9
Arm fat percentage (left)	1.5	5.9	11.2	3.3	0.7	-2.9	-3.0	2.2	2.5	3.1	-1.3	0.9	3.3	1.4
Average weekly red wine intake	0.3	0.5	3.3	0.7	0.1	-0.2	0.1	0.6	0.5	0.2	-0.0	0.3	0.9	1.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	-0.4	-0.6	0.9	-0.5	0.2	-0.0	-0.2	-0.1	-0.3	-0.6	-0.7
Mood swings	1.5	2.8	12.0	1.5	0.8	-0.3	-1.3	0.7	0.6	0.9	3.4	-0.1	0.8	3.5
Loneliness, isolation	0.9	1.2	6.8	0.3	0.1	-1.2	-1.7	-0.0	-0.6	-0.4	2.6	0.0	0.0	-1.2
Long-standing illness, disability or infirmity	1.2	1.9	4.5	-0.0	1.0	-2.1	-2.0	-0.3	-0.1	1.7	2.0	-0.6	-0.1	-1.9
Ever had bowel cancer screening	1.0	1.2	5.9	-1.4	-0.0	1.1	0.9	0.0	-1.1	-0.2	2.4	-0.8	-1.1	0.3
Diabetes diagnosed by doctor	3.0	4.9	14.9	3.5	1.6	0.0	-0.6	1.9	3.1	3.1	0.2	0.7	3.9	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	1.2	0.1	0.4	-0.2	-0.1	0.2	-0.4	-1.1	0.9	0.7	-0.2	-0.1
Friendships satisfaction	0.6	0.7	2.0	0.8	0.7	-1.4	-0.8	0.1	1.2	1.3	-0.2	-0.1	0.8	0.3
Qualifications: nursing, teaching	0.4	0.7	2.2	-1.2	0.8	-0.0	0.3	-0.8	-0.3	-0.3	-0.6	0.0	-1.5	1.4
Commuting to job workplace: Walk	0.3	0.3	1.3	-0.2	-0.6	0.6	0.2	0.0	0.3	-0.2	1.1	0.2	-0.9	-0.1
Eye problems/disorders: Cataract	0.9	1.0	4.7	-1.3	-0.4	1.3	0.4	-1.5	-2.2	-0.3	0.0	-0.4	-0.7	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.3	1.0	-1.9	-1.2	-1.0	1.7	1.5	-0.2	2.1	0.9	0.6	0.1
Medication for cholesterol	1.7	2.6	8.1	-1.7	-2.7	1.5	1.0	0.4	-0.9	-2.8	0.3	1.0	-1.7	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.7	0.4	-0.4	-0.9	0.1	0.3	0.1	-0.7	0.1	0.4	0.1	-0.0
Back pain experienced in last month	1.3	1.9	6.9	1.7	-0.0	-0.9	-1.4	1.7	1.8	-0.1	2.6	1.2	1.0	0.2
Mineral and other dietary supplements	1.0	1.4	4.0	1.5	-0.4	-0.9	-1.5	1.0	0.6	0.3	-0.7	1.1	1.6	2.0
Breast cancer (self-reported)	0.3	0.3	1.0	0.3	0.7	0.6	-0.1	-0.8	-0.4	0.9	-0.1	-0.0	0.4	1.0
Asthma (self-reported)	0.5	1.0	3.8	0.8	-1.5	-0.8	-0.2	1.9	1.1	-0.2	0.8	0.6	0.9	0.2
Osteoporosis (self-reported)	1.2	1.5	5.5	-1.5	-0.3	2.0	2.3	-0.6	-0.8	-0.3	-0.7	-1.0	-1.2	-0.8
Osteoarthritis (self-reported)	0.7	0.8	5.5	0.2	1.0	-0.3	-0.1	-0.2	0.3	0.9	2.4	-0.3	1.0	-0.8
Medication: Aspirin	4.0	5.3	12.0	-2.9	3.0	-0.7	-1.1	-3.5	-2.9	1.3	0.2	-3.1	-2.4	-1.5
Medication: Gliclazide	0.5	0.6	2.8	-0.3	0.7	0.9	-0.0	0.1	0.2	0.9	1.1	-0.3	0.5	-1.7
Illnesses of father: None of the above (group 1)	0.7	0.9	4.3	0.1	-2.1	-0.0	0.5	2.0	0.4	-0.5	0.6	0.7	0.4	0.0
Smoking status: Current	1.2	1.9	5.4	0.7	1.4	-2.2	-2.3	-0.8	0.2	2.2	0.9	-1.1	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.1	-1.0	0.2	1.5	1.4	-0.5	-0.4	1.0	-0.5	-1.4	-0.9	-0.2
Whole body water mass	0.2	1.0	3.3	0.4	1.0	-0.8	-0.2	1.3	-0.3	1.7	-1.8	-0.9	0.6	-0.6
Leg predicted mass (right)	0.2	1.2	3.6	0.2	1.2	-1.3	-0.8	0.6	-0.5	1.8	-1.9	-1.0	0.4	-0.9
Arm fat mass (left)	1.4	5.8	11.6	3.3	0.7	-2.7	-2.6	2.6	2.3	3.4	-1.4	0.6	3.4	1.3
Number of self-reported non-cancer illnesses	1.2	2.1	6.1	1.4	1.6	-1.2	-1.4	0.6	0.7	2.5	2.1	-1.0	1.7	0.2
Average weekly champagne plus white wine intake	1.1	1.5	4.5	0.7	-1.6	0.3	1.1	2.1	1.0	-0.2	-1.5	1.4	1.3	0.5
Miserableness	1.6	2.8	26.0	0.4	-0.6	-0.3	-1.3	0.2	-0.0	0.1	5.1	-0.4	-0.2	1.7
Guilty feelings	2.1	3.2	27.5	1.1	-1.2	0.8	-0.1	1.1	0.5	0.5	5.2	0.1	1.5	0.5
Wears glasses or contact lenses	1.5	1.7	6.6	-1.6	1.2	1.3	1.2	-1.7	-2.6	0.3	-0.5	-1.1	-0.9	-0.2
Ever taken oral contraceptive pill	0.7	0.8	3.4	0.1	-1.5	1.1	1.8	0.3	0.0	-0.6	-1.1	0.1	-0.2	-0.5
Hearing aid user	0.9	1.1	3.9	-1.0	0.1	-0.6	-1.6	-0.7	-1.4	-0.7	0.8	-0.1	-2.0	0.3
Mother’s age at death	0.6	0.7	3.2	-0.9	-0.4	1.8	1.1	-0.6	-0.2	-0.5	0.1	-0.7	-0.8	-0.9
Financial situation satisfaction	3.8	4.7	13.9	3.7	-0.0	-0.1	-0.8	2.5	3.4	1.4	0.5	2.1	3.3	1.4
Tinnitus: Yes, now most or all of the time	2.1	2.4	5.7	-2.2	0.8	-0.3	-0.8	-2.2	-2.2	0.4	1.3	-1.6	-2.4	-1.1
Commuting to job workplace: Public transport	1.0	1.2	5.9	-0.8	0.4	-2.4	-2.1	-0.9	-0.4	-0.5	0.4	-0.0	-0.3	0.8
Eye problems/disorders: Glaucoma	0.5	0.6	1.8	-0.6	-0.3	-1.4	-1.0	-0.0	-0.9	-0.2	0.9	-0.3	0.2	1.3
Medication: Blood pressure	0.7	1.3	5.8	1.2	2.4	-0.6	-0.3	-0.6	0.1	1.9	-0.2	-0.4	1.6	0.5
Pain type(s) experienced in last month: Hip pain	1.5	1.9	14.2	0.2	-0.0	1.1	0.7	0.4	0.2	-1.4	0.7	1.3	0.9	-3.8
Supplements: Fish oil (including cod liver oil)	1.6	2.0	4.3	-1.7	1.4	0.3	0.2	-2.1	-1.3	-0.0	0.5	-1.6	-2.0	-2.1
High cholesterol (Self-reported)	0.5	0.9	2.2	-0.7	1.5	-0.8	-1.0	-0.9	-0.4	1.0	1.4	-0.9	-0.4	-0.6
Medication: Bendroflumethiazide	0.5	0.8	2.7	-0.4	1.6	0.3	-0.3	-1.0	-0.9	0.3	1.2	-0.9	-0.1	-1.1
Medication: Paracetamol	2.3	3.5	7.5	1.9	-1.1	-1.8	-2.7	2.6	2.2	0.2	2.7	1.1	1.5	-0.9
Medication: Lisinopril	2.1	2.8	4.6	-1.7	2.0	-1.6	-1.6	-2.0	-1.4	1.8	-0.4	-2.1	-2.0	-0.3
Medication: Atorvastatin	0.6	0.7	2.0	0.8	-0.1	-0.7	-0.6	0.8	0.8	0.1	1.2	0.5	1.3	-1.4
Illnesses of father: High blood pressure	0.5	0.6	1.7	-0.1	1.3	0.3	0.8	-0.9	-0.8	-1.0	-1.2	0.2	-0.2	-0.8
Alcohol drinker status: Never	4.1	5.0	11.7	3.0	-1.8	0.8	-0.2	3.4	3.1	-0.9	1.4	2.8	2.9	0.9
Ever smoked	1.6	2.7	9.0	-1.8	0.7	-1.9	-1.6	-1.3	-1.5	1.1	1.1	-3.0	-2.2	-0.3
Basal metabolic rate	0.2	1.3	3.9	0.9	0.7	-1.2	-0.7	1.8	0.3	2.0	-1.6	-0.5	1.1	-0.2
Leg fat percentage (left)	2.6	9.3	22.5	4.6	0.1	-2.1	-1.8	3.6	4.0	3.7	-0.2	1.4	4.7	2.5
Arm fat-free mass (left)	0.4	1.9	7.7	1.3	1.3	-0.5	0.0	1.9	0.6	2.8	-1.7	-0.8	1.5	0.1
Number of operations (self-reported)	0.3	0.5	2.2	0.6	-0.2	0.8	1.5	0.4	0.1	0.6	0.3	-0.5	0.7	-0.7
Average weekly beer plus cider intake	0.7	1.1	4.7	0.6	0.7	0.7	1.0	-0.3	-0.2	0.5	-1.8	-0.7	0.4	2.2
Irritability	1.2	2.0	4.7	1.8	1.4	-1.8	-2.2	0.1	1.7	1.0	1.5	0.1	1.6	0.9
Risk taking	0.5	0.7	1.7	1.0	0.2	-1.0	-0.1	0.8	0.1	1.2	-1.2	-0.2	0.7	1.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	-0.2	-0.7	0.2	0.5	-0.1	-0.5	-0.0	-0.4	-0.1	-0.3	-0.5
Fractured/broken bones in last 5 years	1.0	1.3	5.1	-0.9	-1.3	1.2	2.3	0.2	-0.3	0.3	-0.3	-1.3	-0.7	-1.5
Age started oral contraceptive pill	1.5	1.8	7.3	-0.6	-2.6	0.1	-0.2	1.4	0.3	-1.5	2.7	1.0	-0.1	-0.7
Diastolic blood pressure, automated reading	0.9	2.7	12.4	0.6	3.5	-0.9	0.0	-1.4	-0.4	2.3	-2.2	-1.9	0.5	0.1
Ever depressed for a whole week	0.5	0.6	1.7	0.5	0.9	-0.7	-1.3	-0.7	0.3	0.7	1.3	0.4	0.5	0.5
Unable to work because of sickness or disability	0.7	1.0	2.8	0.6	0.0	-1.6	-1.7	1.0	1.1	0.5	0.7	-0.3	-0.6	-1.3
Commuting to job workplace: Cycle	0.9	1.0	4.1	-1.1	-0.6	-0.4	-0.2	-0.3	-0.8	-2.0	0.8	0.9	-1.2	-1.4
Myopia	0.3	0.5	1.2	0.9	1.0	-0.3	-0.5	-0.2	0.8	0.4	-0.8	0.9	1.1	-0.2
Vascular/heart problems diagnosed by doctor	0.9	2.5	14.5	0.0	-3.8	0.9	0.8	1.6	1.7	-1.8	-0.9	1.5	-0.4	0.0
Cholesterol lowering medication	1.0	1.4	6.8	0.3	1.6	-1.1	-1.0	-0.7	0.4	2.6	-0.6	-1.3	0.7	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	5.3	1.6	-0.5	-0.9	-1.1	0.9	1.9	0.4	2.3	0.6	1.1	-0.5
Pain experienced in last month	0.4	0.6	1.7	-0.9	0.1	-0.0	0.5	-1.0	-0.6	-0.2	-1.2	-0.6	-1.0	1.3
Supplements: Calcium	0.5	0.6	1.7	-1.3	-0.1	-1.0	-0.0	-0.1	0.1	-1.0	1.2	0.2	-1.2	-0.0
Basal cell carcinoma (self-reported)	1.6	1.9	7.7	-1.4	0.8	-2.8	-2.5	-0.9	-0.4	-0.4	0.9	-0.7	-1.1	-0.4
Heart attack/myocardial infarction (self-reported)	2.7	3.5	9.2	-2.4	0.2	-1.0	-1.3	-2.1	-2.8	-2.1	0.9	-0.0	-1.8	-3.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.2	-0.3	0.7	0.6	0.3	0.3	0.2	1.1	0.4	-1.1	-0.2	0.0
Heart disease (siblings)	0.4	0.5	1.5	-0.7	0.7	-0.2	-0.2	-0.9	-1.2	0.3	1.1	-0.7	-0.1	-0.9
Alcohol drinker status: Previous	0.2	0.2	0.5	0.7	0.3	-0.0	-0.4	0.1	0.4	0.2	-0.5	0.4	0.6	0.7
Pack years of smoking	1.3	2.0	4.7	1.6	0.9	-1.8	-0.5	0.6	1.2	2.2	-1.9	0.1	1.7	1.1
Impedance of whole body	1.6	8.0	36.1	0.7	-6.0	0.3	-0.1	3.2	2.2	-4.0	3.2	3.1	0.2	0.7
Leg fat mass (left)	1.8	6.9	14.7	3.7	0.6	-2.3	-1.9	3.3	2.9	3.8	-1.0	0.6	3.8	1.9
Arm predicted mass (left)	0.4	1.9	7.4	1.3	1.3	-0.5	0.0	1.9	0.6	2.7	-1.7	-0.8	1.5	-0.1