[Hub]/) : Traits : Impedance of leg (right) : ← →

chr17:42,138,392-43,913,030

Best TWAS P=2.33e-11 · Best GWAS P=3.82e-09 conditioned to 0.462

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	GTEx	Artery Aorta	DCAKD	0.22	0.16	enet	26	0.19	1.1e-10	4.6	-6.7	2.3e-11	-0.62	0.64	0.34	TRUE
5	GTEx	Brain Cortex	CRHR1-IT1	0.28	0.15	lasso	12	0.15	5.6e-05	-4.6	-5.6	2.6e-08	-0.26	0.23	0.41	TRUE
8	GTEx	Breast Mammary Tissue (Female)	ADAM11	0.37	-0.01	enet	90	0.02	6.0e-02	-1.1	-5.1	2.7e-07	-0.17	0.08	0.08	TRUE
27	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LOC644172	0.19	-0.01	blup	81	0.03	1.3e-02	-3.2	-6.3	2.8e-10	-0.47	0.02	0.45	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	HEXIM1	0.05	0.05	blup	47	0.04	8.5e-05	5.7	-6.0	1.4e-09	-0.74	0.01	0.99	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC644172	0.08	0.00	blup	79	0.04	3.2e-04	-4.2	-6.0	1.8e-09	-0.57	0.03	0.70	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC644172	0.14	0.07	enet	10	0.12	1.2e-23	-3.1	-6.0	2.1e-09	-0.36	0.98	0.00	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC644172	0.15	0.01	blup	77	0.06	1.0e-06	-3.9	-6.0	2.4e-09	-0.32	0.22	0.14	FALSE
38	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC644172	0.20	0.01	enet	12	0.06	4.5e-03	3.1	-5.9	3.9e-09	-0.43	0.06	0.13	FALSE
14	GTEx	Lung	DCAKD	0.22	0.05	enet	27	0.10	5.2e-08	-4.8	-5.9	4.8e-09	-0.56	0.49	0.49	FALSE
15	GTEx	Muscle Skeletal	DCAKD	0.12	0.06	enet	16	0.07	9.9e-08	4.8	-5.8	5.2e-09	-0.75	0.10	0.90	FALSE
4	GTEx	Brain Cerebellum	ACBD4	0.40	0.06	lasso	8	0.17	1.0e-05	-4.2	5.7	1.2e-08	0.32	0.09	0.18	FALSE
9	GTEx	Colon Transverse	DCAKD	0.28	0.18	lasso	8	0.26	1.5e-12	4.5	-5.5	3.0e-08	-0.64	0.56	0.44	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC644172	0.11	0.01	enet	7	0.05	2.9e-06	-3.1	-5.5	3.1e-08	-0.35	0.40	0.03	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	NMT1	0.24	0.21	lasso	4	0.22	2.8e-08	-4.8	5.5	3.5e-08	0.62	0.38	0.58	FALSE
12	GTEx	Esophagus Mucosa	DCAKD	0.33	0.32	enet	20	0.35	5.6e-24	4.6	-5.5	4.5e-08	-0.69	0.63	0.36	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCAKD	0.07	0.07	lasso	4	0.07	1.4e-08	4.8	-5.5	4.8e-08	-0.70	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	MGC57346	0.02	0.00	blup	62	0.02	2.2e-05	-3.2	-5.4	5.7e-08	-0.51	0.05	0.48	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	C17orf69	0.04	0.01	blup	49	0.02	6.9e-06	-4.2	-5.4	6.2e-08	-0.50	0.06	0.64	FALSE
16	GTEx	Pancreas	CRHR1-IT1	0.37	0.45	enet	22	0.44	3.5e-20	-4.6	-5.4	8.0e-08	-0.21	0.35	0.63	FALSE
21	YFS	Blood	HEXIM2	0.02	0.01	bslmm	279	0.01	1.0e-05	-3.8	5.4	8.5e-08	0.54	0.06	0.93	FALSE
1	GTEx	Adrenal Gland	PLEKHM1	0.21	0.00	enet	20	0.08	1.0e-03	-3.3	-5.4	8.6e-08	-0.22	0.08	0.13	FALSE
3	GTEx	Artery Tibial	NMT1	0.11	0.09	lasso	5	0.10	6.3e-08	4.5	5.3	8.9e-08	0.58	0.51	0.48	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	C17orf69	0.18	0.04	enet	21	0.05	1.8e-06	-3.2	-5.3	9.3e-08	-0.19	0.14	0.14	FALSE
7	GTEx	Breast Mammary Tissue (Male)	DCAKD	0.36	0.29	lasso	8	0.33	1.4e-08	4.5	-5.3	9.7e-08	-0.71	0.28	0.62	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	DCAKD	0.30	0.21	lasso	6	0.20	5.0e-11	4.8	-5.3	1.0e-07	-0.73	0.37	0.62	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC644172	0.04	0.00	enet	15	0.02	4.0e-03	5.7	-5.3	1.1e-07	-0.50	0.00	0.60	FALSE
13	GTEx	Heart Left Ventricle	DCAKD	0.17	0.17	lasso	3	0.17	2.3e-09	4.6	-5.3	1.2e-07	-0.80	0.12	0.87	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	ACBD4	0.04	0.01	enet	7	0.03	2.2e-04	-3.3	5.3	1.4e-07	0.64	0.04	0.60	FALSE
19	GTEx	Thyroid	ACBD4	0.20	0.16	enet	23	0.15	1.2e-11	3.5	5.3	1.5e-07	0.45	0.98	0.01	FALSE
28	The Cancer Genome Atlas	Esophageal Carcinoma	LOC644172	0.19	0.12	lasso	3	0.05	8.2e-03	4.9	-5.3	1.5e-07	-0.66	0.02	0.41	FALSE
18	GTEx	Skin Sun Exposed Lower leg	DCAKD	0.33	0.20	enet	30	0.31	2.4e-26	4.6	-5.2	1.8e-07	-0.59	0.66	0.33	FALSE
22	YFS	Blood	NMT1	0.02	0.01	lasso	6	0.01	5.0e-03	-3.9	5.2	1.9e-07	0.53	0.18	0.38	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DCAKD	0.04	0.02	blup	66	0.02	3.5e-03	4.9	-5.2	1.9e-07	-0.71	0.01	0.96	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DCAKD	0.03	0.04	lasso	2	0.03	3.8e-04	5.0	-5.2	2.1e-07	-0.67	0.01	0.97	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	DCAKD	0.42	0.36	lasso	7	0.37	3.8e-14	4.8	-5.2	2.3e-07	-0.73	0.44	0.56	FALSE
6	GTEx	Brain Putamen basal ganglia	CRHR1-IT1	0.14	0.22	enet	11	0.21	1.2e-05	-4.6	-5.2	2.4e-07	-0.18	0.16	0.32	FALSE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	MAPT	0.12	0.00	blup	83	0.05	1.3e-02	-3.1	5.2	2.4e-07	0.25	0.02	0.08	FALSE
20	METSIM	Adipose	NMT1	0.13	0.11	lasso	6	0.11	5.7e-16	4.9	5.1	3.0e-07	0.71	0.23	0.77	FALSE