[Hub]/) : Traits : Impedance of leg (right) : ← →

chr17:38,957,953-41,393,295

Best TWAS P=2.48e-12 · Best GWAS P=9.36e-12 conditioned to 0.728

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
79	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NT5C3L	0.18	0.10	lasso	3	0.11	2.5e-12	-6.8	-7.0	2.5e-12	0.94	0.01	0.99	TRUE
34	GTEx	Lung	NAGLU	0.16	0.06	enet	29	0.06	1.5e-05	-4.4	5.9	4.4e-09	-0.06	0.04	0.90	TRUE
43	GTEx	Pancreas	NT5C3B	0.37	0.36	lasso	10	0.39	1.2e-17	-6.4	-7.0	3.2e-12	0.97	0.03	0.97	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	FKBP10	0.11	0.08	lasso	2	0.04	1.2e-02	-6.8	-6.9	5.9e-12	0.99	0.04	0.86	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	NT5C3B	0.47	0.58	enet	16	0.62	3.8e-28	-6.4	-6.8	8.1e-12	0.96	0.04	0.96	FALSE
38	GTEx	Muscle Skeletal	FKBP10	0.05	0.01	lasso	5	0.01	1.9e-02	-5.5	-6.8	9.3e-12	0.82	0.04	0.94	FALSE
64	NTR	Blood	KLHL11	0.03	0.02	blup	402	0.01	2.1e-05	-5.5	-6.8	1.4e-11	0.80	0.04	0.96	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NT5C3L	0.16	0.22	lasso	9	0.21	3.6e-09	-6.8	-6.8	1.4e-11	0.99	0.01	0.99	FALSE
40	GTEx	Nerve Tibial	FKBP10	0.21	0.24	enet	11	0.24	2.3e-17	-6.4	-6.7	1.5e-11	0.97	0.04	0.96	FALSE
25	GTEx	Colon Transverse	NT5C3B	0.37	0.41	lasso	3	0.39	6.1e-20	-6.8	-6.7	1.6e-11	0.99	0.02	0.98	FALSE
30	GTEx	Esophagus Muscularis	FKBP10	0.20	0.13	lasso	5	0.11	2.1e-07	-6.8	-6.7	1.6e-11	0.99	0.02	0.98	FALSE
36	GTEx	Lung	FKBP10	0.07	0.03	lasso	3	0.02	1.4e-02	-6.7	-6.7	1.6e-11	1.00	0.02	0.96	FALSE
39	GTEx	Nerve Tibial	NT5C3B	0.54	0.64	enet	18	0.66	7.9e-61	-6.5	-6.7	1.6e-11	0.95	0.06	0.94	FALSE
62	METSIM	Adipose	NT5C3B	0.16	0.24	lasso	10	0.24	4.0e-35	-6.8	-6.7	1.6e-11	0.99	0.02	0.98	FALSE
67	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	NT5C3L	0.06	0.07	lasso	3	0.07	1.8e-04	-6.8	-6.7	1.6e-11	1.00	0.01	0.97	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	AC019349.5	0.07	0.00	enet	16	0.02	2.5e-02	-6.8	-6.7	1.7e-11	0.91	0.03	0.94	FALSE
83	The Cancer Genome Atlas	Rectum Adenocarcinoma	NT5C3L	0.23	0.13	lasso	12	0.10	1.9e-03	-6.8	-6.7	1.9e-11	0.99	0.01	0.79	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	NT5C3B	0.44	0.60	lasso	7	0.62	1.3e-42	-6.5	-6.7	2.4e-11	0.99	0.03	0.97	FALSE
51	GTEx	Spleen	NT5C3B	0.41	0.42	lasso	3	0.43	1.9e-12	-6.7	-6.7	2.4e-11	0.99	0.03	0.97	FALSE
2	GTEx	Adipose Subcutaneous	NT5C3B	0.50	0.64	enet	25	0.66	1.9e-70	-6.5	-6.7	2.6e-11	0.95	0.07	0.93	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NT5C3L	0.12	0.15	lasso	4	0.15	1.9e-16	-6.8	-6.7	2.7e-11	0.99	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	NT5C3L	0.11	0.22	lasso	10	0.23	1.4e-25	-6.8	-6.7	2.8e-11	0.99	0.01	0.99	FALSE
50	GTEx	Skin Sun Exposed Lower leg	FKBP10	0.07	0.03	lasso	3	0.02	6.9e-03	-4.4	-6.6	3.0e-11	0.82	0.03	0.96	FALSE
65	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NT5C3L	0.04	0.04	lasso	1	0.04	5.3e-04	-6.6	-6.6	3.0e-11	0.99	0.01	0.98	FALSE
69	The Cancer Genome Atlas	Esophageal Carcinoma	NT5C3L	0.10	0.13	lasso	1	0.11	2.0e-04	-6.6	-6.6	3.0e-11	0.99	0.01	0.91	FALSE
57	GTEx	Thyroid	NT5C3B	0.16	0.13	lasso	7	0.12	1.3e-09	-6.7	6.6	3.5e-11	-1.00	0.03	0.97	FALSE
80	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	NT5C3L	0.09	0.10	blup	17	0.11	8.8e-08	-6.6	-6.6	3.5e-11	0.99	0.01	0.99	FALSE
84	The Cancer Genome Atlas	Soft Tissue Sarcoma	NT5C3L	0.16	0.19	lasso	5	0.19	2.0e-11	-6.4	-6.6	3.5e-11	0.96	0.03	0.97	FALSE
61	METSIM	Adipose	CNP	0.04	0.02	blup	367	0.03	8.7e-05	-6.3	6.6	3.7e-11	-0.68	0.04	0.94	FALSE
73	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NT5C3L	0.11	0.18	lasso	1	0.17	6.5e-10	-6.6	-6.6	3.7e-11	1.00	0.01	0.99	FALSE
37	GTEx	Muscle Skeletal	NT5C3B	0.35	0.48	lasso	8	0.48	5.5e-53	-6.5	-6.6	3.9e-11	0.98	0.06	0.94	FALSE
4	GTEx	Adipose Visceral Omentum	NT5C3B	0.41	0.59	lasso	6	0.59	6.4e-37	-6.5	-6.6	4.0e-11	0.98	0.03	0.97	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	NT5C3B	0.13	0.14	enet	8	0.10	1.3e-03	-6.4	-6.6	4.1e-11	0.99	0.03	0.94	FALSE
49	GTEx	Skin Sun Exposed Lower leg	NT5C3B	0.46	0.61	lasso	6	0.62	7.1e-66	-6.5	-6.6	4.6e-11	0.98	0.04	0.96	FALSE
13	GTEx	Brain Cerebellum	NT5C3B	0.41	0.29	lasso	5	0.36	2.1e-11	-6.7	-6.6	4.7e-11	1.00	0.03	0.97	FALSE
45	GTEx	Prostate	NT5C3B	0.56	0.56	lasso	8	0.55	2.3e-16	-6.5	-6.6	4.7e-11	0.97	0.04	0.96	FALSE
76	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CNP	0.07	0.07	blup	16	0.07	3.5e-04	-6.3	-6.6	4.8e-11	0.94	0.01	0.92	FALSE
8	GTEx	Artery Coronary	NT5C3B	0.45	0.52	lasso	3	0.52	5.3e-20	-6.5	-6.6	4.9e-11	0.97	0.04	0.96	FALSE
52	GTEx	Stomach	NT5C3B	0.28	0.38	lasso	5	0.38	1.8e-19	-6.4	-6.5	5.8e-11	0.97	0.06	0.94	FALSE
78	The Cancer Genome Atlas	Lung Adenocarcinoma	NT5C3L	0.06	0.09	lasso	6	0.09	1.8e-10	-6.4	-6.5	5.8e-11	0.98	0.01	0.99	FALSE
53	GTEx	Testis	NT5C3B	0.39	0.48	lasso	3	0.45	6.5e-22	-6.5	-6.5	6.3e-11	0.97	0.06	0.94	FALSE
77	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	NT5C3L	0.14	0.16	lasso	5	0.16	5.2e-08	-6.4	-6.5	6.4e-11	0.98	0.02	0.98	FALSE
10	GTEx	Artery Tibial	NT5C3B	0.49	0.63	lasso	2	0.63	1.1e-62	-6.5	-6.5	6.7e-11	0.97	0.06	0.94	FALSE
15	GTEx	Brain Frontal Cortex BA9	NT5C3B	0.23	0.27	lasso	2	0.27	8.4e-08	-6.5	-6.5	6.7e-11	0.97	0.04	0.96	FALSE
29	GTEx	Esophagus Muscularis	NT5C3B	0.47	0.65	lasso	2	0.65	8.1e-51	-6.5	-6.5	6.7e-11	0.97	0.07	0.93	FALSE
31	GTEx	Heart Atrial Appendage	NT5C3B	0.37	0.43	lasso	3	0.42	3.5e-20	-6.5	-6.5	6.7e-11	0.97	0.05	0.95	FALSE
9	GTEx	Artery Coronary	FKBP10	0.13	0.08	lasso	2	0.06	5.7e-03	-6.5	-6.5	6.8e-11	0.96	0.04	0.88	FALSE
19	GTEx	Breast Mammary Tissue	NT5C3B	0.49	0.60	lasso	4	0.62	3.9e-40	-6.5	-6.5	7.0e-11	0.97	0.07	0.93	FALSE
20	GTEx	Breast Mammary Tissue (Female)	NT5C3B	0.44	0.50	lasso	4	0.51	1.5e-17	-6.5	-6.5	7.0e-11	0.97	0.04	0.96	FALSE
6	GTEx	Artery Aorta	NT5C3B	0.53	0.62	lasso	3	0.62	2.0e-42	-6.5	-6.5	7.3e-11	0.97	0.07	0.93	FALSE
87	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NT5C3L	0.08	0.06	blup	17	0.05	8.6e-03	-6.7	-6.5	7.5e-11	0.98	0.01	0.63	FALSE
35	GTEx	Lung	NT5C3B	0.47	0.64	lasso	5	0.64	2.6e-62	-6.5	-6.5	8.4e-11	0.97	0.06	0.94	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	KLHL10	0.05	0.06	blup	22	0.06	2.5e-06	-6.6	6.5	8.5e-11	-0.92	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NT5C3L	0.20	0.21	lasso	5	0.21	6.2e-23	-6.4	-6.5	9.0e-11	0.97	0.05	0.95	FALSE
59	GTEx	Uterus	NT5C3B	0.35	0.38	lasso	3	0.39	6.3e-09	-6.5	-6.5	9.3e-11	0.97	0.04	0.94	FALSE
14	GTEx	Brain Cortex	NT5C3B	0.37	0.29	enet	13	0.38	1.6e-11	-6.7	-6.5	9.7e-11	0.96	0.03	0.97	FALSE
44	GTEx	Pituitary	NT5C3B	0.41	0.38	lasso	3	0.35	1.4e-09	-6.5	-6.5	1.0e-10	0.97	0.04	0.96	FALSE
24	GTEx	Colon Sigmoid	NT5C3B	0.50	0.56	lasso	6	0.55	6.4e-23	-6.4	-6.4	1.3e-10	0.97	0.05	0.95	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	NT5C3L	0.10	0.12	lasso	2	0.12	6.5e-24	-6.4	-6.4	1.4e-10	0.96	0.05	0.95	FALSE
85	The Cancer Genome Atlas	Skin Cutaneous Melanoma	NT5C3L	0.10	0.10	lasso	3	0.10	1.2e-03	-6.4	-6.4	1.4e-10	0.96	0.01	0.66	FALSE
12	GTEx	Brain Cerebellar Hemisphere	NT5C3B	0.23	0.12	lasso	5	0.10	1.5e-03	-6.4	-6.4	1.5e-10	0.98	0.04	0.91	FALSE
16	GTEx	Brain Hypothalamus	NT5C3B	0.37	0.23	lasso	5	0.22	5.1e-06	-6.4	-6.4	1.5e-10	0.96	0.04	0.95	FALSE
22	GTEx	Cells Transformed fibroblasts	NT5C3B	0.62	0.73	lasso	8	0.74	2.3e-81	-6.5	-6.4	1.6e-10	0.97	0.07	0.93	FALSE
3	GTEx	Adipose Subcutaneous	FKBP10	0.09	0.03	lasso	5	0.04	1.6e-04	-5.0	-6.4	1.7e-10	0.79	0.10	0.89	FALSE
70	The Cancer Genome Atlas	Glioblastoma Multiforme	NT5C3L	0.21	0.32	lasso	12	0.32	2.7e-10	-6.4	-6.4	1.7e-10	0.96	0.01	0.99	FALSE
58	GTEx	Thyroid	RP11-156E6.1	0.23	0.21	lasso	6	0.23	1.2e-17	-6.7	6.4	1.8e-10	-0.99	0.03	0.97	FALSE
89	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ACLY	0.12	0.00	blup	42	0.02	8.6e-02	-5.4	6.4	1.9e-10	-0.82	0.02	0.34	FALSE
86	The Cancer Genome Atlas	Stomach Adenocarcinoma	NT5C3L	0.08	0.10	blup	17	0.11	2.3e-08	-6.4	-6.4	2.0e-10	0.98	0.01	0.99	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	NT5C3L	0.13	0.17	lasso	7	0.18	5.3e-18	-6.4	-6.4	2.1e-10	0.96	0.03	0.97	FALSE
42	GTEx	Ovary	NT5C3B	0.62	0.58	lasso	6	0.61	1.3e-18	-6.4	-6.3	3.0e-10	0.97	0.04	0.96	FALSE
60	GTEx	Whole Blood	NT5C3B	0.38	0.38	lasso	4	0.40	1.2e-38	-6.5	-6.3	3.8e-10	0.96	0.06	0.94	FALSE
28	GTEx	Esophagus Mucosa	NT5C3B	0.39	0.46	enet	16	0.48	8.5e-36	-6.5	-6.3	4.0e-10	0.97	0.06	0.94	FALSE
23	GTEx	Cells Transformed fibroblasts	FKBP10	0.23	0.20	lasso	4	0.19	1.8e-14	-6.5	-6.2	4.8e-10	0.95	0.06	0.94	FALSE
5	GTEx	Adrenal Gland	NT5C3B	0.51	0.49	lasso	6	0.51	3.5e-21	-6.4	-6.2	5.2e-10	0.96	0.06	0.94	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	KRT13	0.07	-0.01	lasso	3	0.01	1.5e-01	-6.8	-6.1	8.4e-10	0.94	0.03	0.93	FALSE
63	NTR	Blood	CNP	0.01	0.01	blup	368	0.01	3.0e-05	-6.5	6.1	9.5e-10	-0.85	0.05	0.95	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	FKBP10	0.25	0.11	lasso	13	0.07	6.5e-03	-6.6	-6.0	1.7e-09	0.97	0.03	0.86	FALSE
11	GTEx	Brain Caudate basal ganglia	NT5C3B	0.28	0.26	enet	13	0.31	1.4e-09	-6.4	-6.0	1.8e-09	0.90	0.04	0.96	FALSE
33	GTEx	Liver	NT5C3B	0.33	0.30	enet	10	0.29	7.1e-09	-6.5	-6.0	1.8e-09	0.96	0.04	0.96	FALSE
32	GTEx	Heart Left Ventricle	NT5C3B	0.35	0.40	enet	22	0.39	5.9e-22	-6.5	-6.0	2.6e-09	0.95	0.06	0.94	FALSE
7	GTEx	Artery Aorta	FKBP10	0.24	0.13	lasso	7	0.12	2.5e-07	-6.5	-5.9	3.3e-09	0.96	0.03	0.97	FALSE
55	GTEx	Thyroid	RAB5C	0.05	0.01	lasso	4	0.01	5.8e-02	-5.5	-5.8	6.5e-09	0.52	0.17	0.33	FALSE
68	The Cancer Genome Atlas	Colon Adenocarcinoma	NT5C3L	0.18	0.21	blup	17	0.23	2.8e-13	-6.8	-5.6	1.6e-08	0.94	0.01	0.99	FALSE
54	GTEx	Testis	CTD-2132N18.2	0.10	0.01	lasso	4	0.00	4.6e-01	-5.7	-5.6	2.0e-08	0.52	0.43	0.19	FALSE
41	GTEx	Nerve Tibial	RP11-156E6.1	0.12	0.08	lasso	5	0.07	5.7e-06	-4.4	-5.5	3.3e-08	0.50	0.78	0.14	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	NT5C3B	0.55	0.53	enet	30	0.57	2.4e-22	-6.5	-5.4	5.4e-08	0.97	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ZNF385C	0.05	0.07	lasso	3	0.05	3.5e-07	-5.5	5.2	1.9e-07	-0.68	0.39	0.61	FALSE
56	GTEx	Thyroid	LEPREL4	0.09	0.03	lasso	4	0.04	3.0e-04	-6.8	5.2	2.2e-07	-0.91	0.03	0.97	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTC25	0.03	0.01	blup	29	0.01	1.4e-02	-6.7	5.2	2.5e-07	-0.88	0.01	0.66	FALSE