TWAS hub - MGC57346

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0246	0.0105	0.00012	0.003	0.022	0.021	NA	0.006	6.2e-02	2.2e-05	2.9e-05	NA	1.5e-02
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0936	0.0429	0.00012	0.018	0.032	0.042	NA	0.047	3.6e-03	1.5e-04	1.5e-05	NA	4.8e-06
3	TCGA	Soft Tissue Sarcoma	0.1380	0.0550	0.00130	0.034	0.046	0.039	NA	0.041	4.2e-03	9.7e-04	2.2e-03	NA	1.8e-03
4	TCGA	Testicular Germ Cell Tumors	0.1120	0.0520	0.00380	0.115	0.071	0.060	NA	0.109	7.4e-05	1.6e-03	3.6e-03	NA	1.1e-04
5	TCGA	Thyroid Carcinoma	0.1370	0.0530	0.00024	0.018	0.018	0.033	NA	0.027	6.7e-03	6.3e-03	3.5e-04	NA	1.1e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Hair/balding pattern: Pattern 4	13.5	32.6	47.7	-6.9	-6.2	-3.7	-5.7	-5.6
Hair/balding pattern: Pattern 3	11.7	17.4	25.5	-5.0	-4.9	-3.5	-3.7	-3.5
Sensitivity / hurt feelings	7.6	13.1	22.0	3.7	4.3	2.7	2.0	4.7
Ovarian Cancer	7.0	9.2	18.1	-2.1	-4.2	-4.1	-2.0	-1.8
Forced vital capacity (FVC), Best measure	6.8	25.0	48.4	-3.5	-7.0	-4.2	-2.6	-6.4
Allergy	6.4	14.7	39.7	4.2	4.0	-0.3	6.3	-0.0
Forced vital capacity (FVC)	6.3	24.4	49.0	-3.3	-7.0	-4.1	-2.8	-6.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.2	13.2	27.4	-3.2	-4.3	-2.5	-1.8	-5.2
Respiratory disease	6.0	13.3	28.7	-4.0	-4.5	-0.1	-5.4	-1.0
Lung FVC	6.0	30.4	57.0	-4.9	-7.5	-3.9	-2.6	-7.0
Forced expiratory volume in 1-second (FEV1), Best measure	6.0	19.2	38.4	-3.0	-6.2	-3.9	-1.4	-5.6
Relative age of first facial hair	5.9	12.2	19.9	4.5	3.7	2.3	3.5	3.0
Forced expiratory volume in 1-second (FEV1)	5.9	19.8	39.6	-3.1	-6.3	-3.8	-1.7	-5.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.8	6.9	9.5	3.1	3.0	2.3	2.8	1.6
Hayfever, allergic rhinitis or eczema	5.4	11.8	26.3	-4.0	-3.8	-1.3	-5.1	1.0
Impedance of arm (left)	5.3	24.7	40.7	-6.4	-5.6	-3.3	-4.0	-4.9
Blood Red Count	5.2	50.1	72.2	7.3	8.5	6.2	5.4	7.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.2	6.1	9.8	-2.9	-3.1	-2.0	-2.3	-1.5
Systolic Blood Pressure	5.0	24.9	47.1	-6.9	-6.0	-0.6	-5.5	-3.4
Allergy or Eczema	5.0	13.2	32.0	-3.9	-4.0	-1.5	-5.7	0.5
Medication: Ventolin 100micrograms inhaler	4.9	6.4	13.3	-2.4	-3.6	0.4	-3.5	-0.6
Impedance of arm (right)	4.8	22.5	38.0	-6.2	-5.7	-3.2	-3.7	-4.3
Alcohol drinker status: Previous	4.7	5.4	10.0	-3.0	-1.7	-2.2	-3.2	-0.2
Mouth/teeth dental problems	4.4	6.7	9.7	-3.1	-2.8	-2.4	-2.1	-2.4
Asthma	4.4	8.6	24.7	-2.4	-3.2	1.5	-5.0	-0.6
Impedance of whole body	4.4	22.5	41.2	-6.4	-5.4	-3.2	-4.0	-4.0
Asthma (self-reported)	4.2	8.4	24.3	-2.2	-3.2	1.5	-4.9	-0.6
Systolic blood pressure, automated reading	4.1	11.9	25.8	-5.1	-3.3	0.2	-4.2	-2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.8	4.5	10.2	-2.1	-1.9	-1.9	-3.2	-0.7
Lupus	3.7	5.6	10.9	-1.9	-1.4	-3.3	-2.5	-2.3
Mouth/teeth dental problems: Bleeding gums	3.7	4.8	6.4	2.5	2.4	2.1	2.2	1.7
Headache pain in last month	3.7	6.3	19.1	2.7	1.1	1.9	-0.4	4.4
Leg pain on walking	3.7	4.6	11.2	1.1	2.5	1.9	0.9	3.3
Handedness (chirality/laterality): Left-handed	3.6	4.3	10.4	-2.0	-3.2	0.4	-2.2	-1.5
Mean Putamen Volume	3.5	4.0	7.0	2.3	2.6	1.7	1.2	1.9
Ever unenthusiastic/disinterested for a whole week	3.5	4.3	6.6	2.4	1.7	2.6	0.4	2.5
Relative age voice broke	3.4	5.3	11.8	2.7	3.4	1.3	1.5	1.8
Hearing difficulty/problems with background noise	3.4	5.4	10.6	1.0	3.1	0.7	2.2	3.3
Ever smoked	3.4	5.9	9.8	-2.6	-2.6	-2.4	-0.7	-3.1
Impedance of leg (right)	3.1	15.2	29.5	-5.4	-4.7	-2.7	-3.4	-2.1
Qualifications: College or University degree	3.1	9.8	22.2	-2.7	-3.6	-4.7	-1.8	-1.8
Waist Hip Ratio (WHR)	3.0	13.5	32.8	1.6	3.5	3.3	3.0	5.7
Hand grip strength (right)	3.0	8.2	17.9	-0.8	-3.7	-3.0	-0.3	-4.2
Past tobacco smoking	3.0	5.4	9.1	2.7	2.7	1.8	0.4	3.0
Medication: Blood pressure	3.0	5.3	10.9	-2.4	-1.4	-3.3	-0.9	-2.7
Neuroticism (Nagel 2018)	2.9	6.9	19.7	2.5	2.3	1.7	0.4	4.4
Number of incorrect matches in round	2.9	4.8	10.9	1.0	3.3	2.3	-0.5	2.5
Supplements: Fish oil (including cod liver oil)	2.9	3.7	6.4	-2.1	-2.4	-0.4	-2.5	-1.5
Depressed Affect (Nagel 2018)	2.8	5.9	14.6	2.2	1.9	2.4	0.8	3.8
Schizophrenia vs Biploar Disorder	2.8	3.7	7.7	-2.7	-1.5	-0.2	-1.0	-2.8
Neuroticism	2.8	6.7	21.4	2.0	2.2	1.6	0.1	4.6
Hand grip strength (left)	2.8	7.3	14.3	-1.0	-3.7	-2.7	-0.3	-3.8
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.3	15.7	1.6	0.8	1.5	-0.7	4.0
Noisy workplace	2.8	3.4	6.4	1.6	1.8	2.5	-0.1	2.2
Emphysema/chronic bronchitis	2.8	3.2	5.6	-2.0	-2.2	0.8	-2.4	-0.8
Illnesses of father: None of the above (group 1)	2.8	3.4	5.4	-1.7	-1.4	-1.9	-2.3	-1.8
Irritability	2.8	4.7	6.8	2.6	2.2	2.2	0.5	2.6
Number of full brothers	2.6	3.3	7.1	1.8	1.2	1.4	2.7	1.7
Worry too long after embarrassment	2.6	4.3	11.3	2.1	1.8	0.8	1.5	3.4
Basal cell carcinoma (self-reported)	2.6	3.1	8.2	-0.6	-2.0	-0.2	-2.9	-1.6
Heel T-Score	2.5	19.6	35.8	-4.7	-6.0	-3.9	-3.3	-3.8
Neuroticism score	2.5	5.2	19.0	1.7	1.7	1.0	0.7	4.4
Number of live births	2.5	3.5	8.5	1.8	1.4	2.9	1.9	-0.5
Mood swings	2.5	4.5	11.4	1.6	2.1	2.1	0.1	3.4
Financial situation satisfaction	2.5	3.0	7.4	-1.9	-2.7	0.1	-1.6	-1.3
Verbal and Numeric Reasoning (VNR)	2.4	5.8	14.0	-0.8	-3.1	-2.1	0.2	-3.7
Blood White Count	2.4	17.7	32.3	2.7	5.1	5.7	4.6	1.3
Smoking Status	2.4	5.8	11.8	-3.4	-2.5	-1.3	-2.4	-1.9
Fed-up feelings	2.4	4.4	10.1	1.4	0.6	2.8	1.2	3.2
Impedance of leg (left)	2.4	11.5	21.7	-4.7	-4.0	-2.6	-2.8	-2.3
Unable to work because of sickness or disability	2.4	3.1	4.9	-2.2	-2.0	-0.9	-1.5	-1.9
Irritable Bowel Disease (IBD)	2.3	5.6	10.6	-2.1	-3.2	-2.0	-2.6	-1.4
Primary Biliary Cirrhosis	2.3	3.3	5.2	-2.3	-2.0	-1.8	-1.2	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	3.0	7.0	-1.5	-2.6	0.3	-2.4	0.1
Age started oral contraceptive pill	2.3	2.9	5.0	2.2	2.2	1.8	0.9	0.9
Crohns Disease (2017)	2.2	4.9	9.9	-1.8	-2.6	-1.7	-3.1	-1.3
Body Mass Index (BMI) (2010)	2.2	3.0	7.6	1.3	1.9	1.1	2.8	1.0
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	4.3	-1.6	-2.1	0.0	-2.0	-1.5
Wears glasses or contact lenses	2.2	2.5	4.9	2.0	1.2	0.4	1.3	2.2
Commuting to job workplace: Public transport	2.2	2.6	5.5	1.6	0.5	-0.8	2.0	2.3
Medication: Paracetamol	2.2	3.4	14.8	1.0	0.0	3.9	-0.8	0.8
Prostate Cancer	2.1	3.0	5.3	2.3	2.1	0.6	1.6	1.5
Ulcerative Colitis	2.1	3.0	4.8	-1.6	-2.2	-1.7	-1.3	-1.8
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	5.3	-2.2	-1.3	0.5	-2.3	-0.9
Supplements: Vitamin C	2.1	2.5	8.5	1.3	0.6	2.9	0.1	1.5
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	6.4	2.5	1.7	1.6	0.5	2.1
Hearing difficulty/problems: Yes	2.0	3.0	6.7	1.2	2.6	1.6	2.0	0.5
Sitting height	2.0	14.5	28.7	-0.6	-4.8	-5.4	-1.2	-4.3
Fluid intelligence score	2.0	4.1	9.1	-1.1	-2.2	-2.3	0.2	-3.0
Medication: Ibuprofen	2.0	2.4	8.0	1.8	0.2	2.8	0.0	0.9
Smoking status: Previous	2.0	3.0	5.5	-2.2	-2.0	-0.7	0.4	-2.3
Mother’s age at death	2.0	2.5	5.4	0.7	2.1	1.2	0.9	2.3
Tinnitus: Yes, now most or all of the time	2.0	2.4	4.8	1.3	2.2	0.4	0.7	2.2
Blood Platelet Count	1.9	22.1	33.3	4.2	5.8	4.8	2.4	5.5
Falls in the last year	1.9	2.6	5.2	1.1	1.5	2.0	0.6	2.3
Medication: Amlodipine	1.9	2.7	6.2	-1.9	-1.3	-1.3	-0.5	-2.5
Pulse wave peak to peak time	1.9	2.2	5.2	-0.9	-1.7	-0.8	-1.3	-2.3
Illnesses of father: Heart disease	1.9	2.7	5.8	0.7	1.7	1.6	1.3	2.4
Eye problems/disorders: Glaucoma	1.9	2.3	4.7	0.8	1.8	0.1	1.6	2.2
Ulcerative Colitis (UC)	1.8	3.4	7.5	-1.9	-2.7	-1.3	-1.5	-1.2
Number of treatments/medications taken	1.8	3.3	6.6	-0.6	-2.0	2.6	-2.3	-0.3
Severe depression (siblings)	1.8	2.1	4.8	1.1	0.6	2.2	-0.2	2.0
High blood pressure	1.8	4.9	10.0	-3.2	-1.7	-2.5	-2.1	-1.2
Trunk fat-free mass	1.8	10.3	33.6	5.8	2.4	-0.1	2.9	1.8
Peak expiratory flow (PEF)	1.8	4.3	10.0	-0.5	-3.2	-1.5	0.1	-3.0
Medication: Paracetamol	1.8	3.0	11.1	0.7	0.7	3.3	-0.8	1.4
Wheeze or whistling in the chest in last year	1.8	3.3	6.4	-1.6	-1.8	1.6	-2.5	1.3
Medication for pain relief, constipation, heartburn	1.8	3.1	7.6	-1.0	-0.4	-2.7	0.8	-2.4
Number of self-reported non-cancer illnesses	1.8	3.0	7.7	-2.3	-1.3	0.6	-2.8	-0.5
Average weekly champagne plus white wine intake	1.8	2.5	3.9	-0.5	-2.0	-1.4	-1.7	-1.9
Average weekly beer plus cider intake	1.8	2.7	4.7	-2.2	-1.9	-0.2	-1.6	-1.5
Ever had prostate specific antigen (PSA) test	1.8	2.1	4.7	2.2	1.6	1.4	1.0	0.3
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	3.9	-2.0	-1.5	-0.9	-1.7	-1.0
Alzheimer’s Disease (in father)	1.7	1.9	5.2	1.9	-0.4	0.4	2.3	-0.3
Medication: Co-codamol	1.7	1.9	3.9	-1.5	-1.8	0.1	-2.0	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	5.9	1.5	0.1	2.4	0.0	1.6
Trunk predicted mass	1.7	9.6	31.8	5.6	2.2	-0.2	2.8	1.8
Exposure to tobacco smoke at home	1.7	1.9	3.3	-1.8	-1.7	-0.1	0.6	-1.8
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	7.9	1.6	0.9	2.8	0.0	1.7
Gout (self-reported)	1.7	2.4	4.8	-1.9	-1.4	-2.2	-0.7	-1.1
Intelligence (Savage-Jansen 2018)	1.6	5.0	8.2	-0.8	-2.8	-2.8	-0.4	-2.9
High blood pressure (siblings)	1.6	2.2	8.1	-1.0	-1.1	0.6	-2.9	0.5
Arm fat-free mass (right)	1.6	8.2	25.5	5.0	2.5	0.3	2.6	1.4
Had major operations	1.6	1.9	4.2	2.0	1.2	0.3	0.7	1.8
Hypertension (Self-reported)	1.6	4.4	9.0	-3.0	-1.6	-2.2	-2.1	-1.0
Smoking status: Current	1.6	2.5	4.5	-2.1	-1.3	-1.4	-2.0	-0.7
Arm fat-free mass (left)	1.6	8.0	24.7	5.0	2.4	0.6	2.4	1.8
Vascular/heart problems diagnosed by doctor	1.6	4.5	11.1	3.3	1.5	2.1	2.0	0.7
Coronary Artery Disease (CAD)	1.5	1.8	4.0	2.0	0.0	1.7	0.8	1.2
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	6.2	-0.5	-0.8	1.4	-2.5	0.8
Taking other prescription medications	1.5	2.4	5.1	-1.8	-1.8	0.2	-2.2	0.2
Prospective memory result	1.5	1.8	3.1	1.0	1.8	1.6	-0.4	1.5
Pulse wave Arterial Stiffness index	1.5	1.8	4.3	0.9	1.4	0.4	1.3	2.1
Medication: Allopurinol	1.5	2.1	4.4	-1.4	-1.1	-2.1	-0.8	-1.5
Arm predicted mass (right)	1.5	7.6	24.7	5.0	2.4	0.4	2.3	1.5
Mineral and other dietary supplements	1.5	2.0	5.8	0.8	1.7	-0.6	2.4	0.5
Fractured/broken bones in last 5 years	1.5	1.9	4.7	1.6	1.3	2.2	0.9	0.1
Ever depressed for a whole week	1.5	1.9	8.7	0.8	0.3	0.3	0.1	3.0
Arm predicted mass (left)	1.5	7.4	23.0	4.8	2.3	0.1	2.3	1.9
Time employed in main current job	1.4	1.6	2.7	-1.4	-1.6	-0.6	-1.2	-1.3
Breastfed as a baby	1.4	1.7	3.4	1.8	0.5	1.8	1.2	-0.5
Shortness of breath walking on level ground	1.4	1.6	3.3	0.4	0.9	1.8	-0.7	1.8
Mouth/teeth dental problems: Loose teeth	1.4	1.6	2.7	-1.6	-1.1	-1.2	-1.6	0.2
Whole body fat-free mass	1.4	8.0	27.7	5.3	2.2	0.2	2.4	1.4
Whole body water mass	1.4	7.7	26.7	5.2	2.1	0.1	2.3	1.4
Heart disease (siblings)	1.4	1.7	3.7	0.4	1.1	1.8	0.3	1.9
Worry (Nagel 2018)	1.3	2.8	11.1	1.0	1.0	0.9	-0.4	3.3
Blood Eosinophil Count	1.3	10.2	28.3	-3.6	-2.7	-1.1	0.8	-5.3
Cardiovascular Disease	1.3	4.3	12.0	-3.5	-1.8	-1.6	-1.8	-0.3
Ever used hormone-replacement therapy (HRT)	1.3	1.7	4.2	1.1	1.2	2.1	-1.2	-0.3
Age when periods started (menarche)	1.3	3.1	4.6	2.0	1.7	-0.6	2.1	1.9
Qualifications: A levels/AS levels or equivalent	1.3	2.8	6.6	-1.5	-1.5	-2.6	0.5	-1.5
Length of working week for main job	1.3	1.4	4.2	-0.1	0.2	-2.0	1.7	-0.2
Neck or shoulder pain in last month	1.3	1.8	3.8	-1.9	-0.7	-0.8	-1.4	-1.5
Comparative height size at age 10	1.3	7.3	15.3	-0.7	-2.8	-3.3	-1.5	-3.9
Medication: Aspirin	1.3	1.7	2.7	1.3	1.6	0.5	1.5	1.4
Average weekly red wine intake	1.3	1.8	4.7	-0.9	-1.2	-2.2	-0.0	-1.5
Diastolic blood pressure, automated reading	1.3	4.0	8.1	-2.5	-1.6	0.7	-2.8	-1.7
Number of children fathered	1.2	1.3	2.6	1.6	1.5	0.3	1.1	0.6
Migraine (self-reported)	1.2	1.4	3.1	0.5	0.8	1.8	-0.2	1.8
Commuting to job workplace: Car/motor vehicle	1.2	1.4	4.0	1.2	2.0	0.3	-0.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	6.1	0.1	-2.4	-2.5	0.1	-0.3
Long-standing illness, disability or infirmity	1.2	1.9	4.2	-2.0	-1.4	0.5	-1.7	-0.1
Number of operations (self-reported)	1.2	1.8	3.3	1.7	1.2	1.0	0.3	1.8
Bipolar Disorder (2018)	1.1	1.8	3.3	1.3	1.8	-0.8	0.9	1.5
Reaction Time	1.1	2.1	8.2	-1.2	-0.1	-2.9	0.3	0.9
Ever had hysterectomy (womb removed)	1.1	1.3	2.5	1.6	0.7	1.4	0.8	1.0
Angina	1.1	1.4	5.6	-2.4	-0.3	1.0	0.3	0.7
Average weekly fortified wine intake	1.1	1.3	2.3	-1.5	-1.2	1.0	-1.3	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	5.5	-0.4	-2.1	-2.3	0.4	-1.4
Medication: Levothyroxine sodium	1.1	1.9	5.1	1.9	0.9	2.3	0.3	0.1
Suffer from ‘nerves’	1.1	1.8	7.0	0.3	1.1	-0.1	0.7	2.6
Overall health rating	1.1	2.4	4.2	-2.1	-0.5	1.5	-1.8	1.5
Chest pain or discomfort	1.1	1.5	4.2	-2.0	-1.6	-0.6	-0.7	0.3
Medication: Atorvastatin	1.1	1.3	2.9	-0.1	-1.4	-0.7	1.2	-1.7
Basal metabolic rate	1.1	6.0	21.4	4.6	1.8	0.4	1.9	1.2
Depression (Nagel 2018)	1.0	1.5	5.5	0.5	-0.0	0.5	-1.2	2.3
Breast Cancer	1.0	2.4	7.7	0.0	2.8	-0.5	1.3	1.6
Age at First Birth	1.0	1.4	2.2	1.3	-1.3	-1.5	0.9	-0.9
Crohns Disease (2012)	1.0	1.7	5.2	-1.5	0.0	-0.8	-2.3	-0.5
Neuroticism (2016)	1.0	1.4	2.5	1.1	1.0	1.6	0.9	1.2
Average weekly spirits intake	1.0	1.2	1.9	1.4	0.8	0.9	1.0	1.4
Trunk fat percentage	1.0	3.8	6.1	-2.5	-1.9	0.6	-1.9	-2.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.1	1.4	1.3	1.0	1.0	0.2
Chronic bronchitis/emphysema (father)	1.0	1.2	3.5	-0.9	-1.9	0.7	-0.7	-0.8
Nervous feelings	1.0	1.9	7.4	-0.3	0.4	-0.5	-1.2	2.7
Hair/balding pattern: Pattern 2	1.0	1.3	2.2	1.2	0.9	1.0	1.0	1.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	4.6	-1.0	-0.3	-0.6	-2.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.9	-1.2	-1.0	-1.7	0.5	0.1
Medication: Lansoprazole	1.0	1.1	2.4	-0.8	-1.5	0.6	-1.1	-1.0
Lung cancer (father)	1.0	1.2	2.8	1.0	1.4	1.7	-0.3	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.0	1.2	-0.5	1.7	0.6	1.6
Health satisfaction	1.0	1.2	3.0	0.4	0.5	1.7	0.8	1.5
Angina (self-reported)	1.0	1.3	4.1	-2.0	-0.1	1.3	0.4	0.8
Leg fat-free mass (right)	1.0	5.3	19.2	4.4	1.7	0.8	1.8	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.2	1.5	0.1	1.1	0.8	1.1
Commuting to job workplace: Walk	1.0	1.1	2.7	0.4	-0.7	1.6	0.3	1.5
Osteoarthritis (self-reported)	1.0	1.3	4.0	0.5	1.3	2.0	-0.5	-0.6
Medication: Aspirin	1.0	1.3	2.5	1.1	1.2	0.3	1.6	1.2
Leg predicted mass (right)	1.0	5.3	19.4	4.4	1.7	0.8	1.9	0.6
Medication: Blood pressure	1.0	1.9	4.0	-2.0	-1.8	-0.5	-1.2	-0.7
Pain experienced in last month	1.0	1.7	3.8	-1.0	-0.9	-1.0	1.4	-1.9
HDL Cholesterol	0.9	1.5	3.6	1.9	1.4	0.7	1.1	0.1
Triglycerides	0.9	1.5	4.2	-2.1	-0.6	-1.6	0.1	0.7
Height	0.9	17.6	44.1	3.3	-3.5	-6.6	0.2	-4.5
Vitamin and mineral supplements	0.9	1.3	2.5	-0.8	-0.2	-1.6	1.5	-0.9
Supplements: Zinc	0.9	1.0	2.6	1.6	0.1	0.7	-0.6	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	5.2	0.2	0.2	0.6	-0.8	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	4.7	-0.7	-1.7	-2.2	1.2	-1.0
Financial difficulties in last 2 years	0.9	1.2	1.8	1.3	1.3	0.2	0.9	1.3
Pain all over the body in last month	0.9	1.0	3.0	0.4	-0.2	0.9	-1.0	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.0	0.1	-1.3	1.7	-0.8	1.5
Pulse wave reflection index	0.9	1.1	1.8	0.7	1.2	0.5	1.4	1.1
Comparative body size at age 10	0.9	2.5	4.3	2.1	1.7	1.7	0.7	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.8	-0.4	1.3	-0.5	1.1	1.3
Medication: Omeprazole	0.9	1.0	2.7	-1.6	-0.8	-1.0	-0.7	-0.3
Mean time to correctly identify matches	0.9	1.6	7.3	-0.5	0.2	-2.7	0.7	0.3
Number of full sisters	0.9	1.1	4.0	0.2	2.0	1.1	-0.6	-0.4
Illnesses of siblings: Diabetes	0.9	1.1	2.8	0.8	1.7	0.6	1.4	-0.2
Illnesses of father: High blood pressure	0.9	1.1	2.3	-1.3	-1.5	-1.0	-0.7	-0.1
Myopia	0.9	1.3	3.3	-0.4	-1.8	-0.8	0.7	-1.4
LDL Cholesterol	0.8	1.3	2.5	-1.2	-1.0	-1.2	-1.6	0.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.9	0.0	-0.7	0.5	-0.9	2.0
Current tobacco smoking	0.8	1.3	2.5	-1.5	-0.6	-1.0	-1.6	-0.5
Body mass index (BMI)	0.8	3.5	8.6	1.5	2.1	2.9	1.1	1.1
Waist circumference	0.8	3.1	6.3	1.7	1.7	2.5	0.9	1.6
Standing height	0.8	7.9	18.1	2.0	-3.2	-4.3	-0.7	-2.6
Tense / ‘highly strung’	0.8	1.4	3.3	-0.9	-0.8	0.3	-1.5	1.8
Birth weight of first child	0.8	1.4	3.4	-0.2	-1.8	-1.9	-0.1	-0.4
Glaucoma (self-reported)	0.8	1.0	2.1	0.6	1.4	-0.0	0.9	1.2
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	5.5	2.3	1.0	1.1	-0.2	-0.2
Eye problems/disorders: None of the above	0.8	0.9	3.3	-0.1	0.4	-0.5	0.9	-1.8
Pulse rate, automated reading	0.8	2.7	5.2	-2.3	-1.1	-1.6	-2.0	-0.6
Medication: Lisinopril	0.8	1.0	3.3	-0.4	-1.8	-0.0	-1.3	0.4
BMI	0.7	3.8	7.8	1.5	2.0	2.8	1.7	1.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.1	-1.0	-0.2	-1.0	0.8	1.1
Diabetes (father)	0.7	0.8	1.4	1.0	0.7	-1.2	1.0	0.6
Leg fat-free mass (left)	0.7	3.5	13.6	3.7	1.1	0.6	1.4	0.5
Illnesses of siblings	0.7	1.0	1.8	0.4	-0.1	-1.3	1.2	-1.3
Blood clot in the leg (DVT)	0.7	0.9	4.2	-0.1	-0.0	0.4	-2.0	-0.0
Exposure to tobacco smoke outside home	0.7	0.9	2.5	0.4	0.0	1.6	1.0	1.0
Family relationship satisfaction	0.7	0.9	2.0	-0.5	-0.2	-0.6	-1.4	1.3
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.7	0.8	1.3	0.7	0.8	0.9
Heart attack/myocardial infarction (self-reported)	0.7	0.8	2.5	-0.8	0.3	-1.6	0.7	0.7
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	1.2	1.0	0.4	0.4	-0.7
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.1	-0.8	-1.4	-0.2	-0.8	0.0
Medication for hormone replacement therapy	0.6	0.7	1.8	1.4	-0.3	1.1	0.1	-0.3
Medication: Metformin	0.6	0.8	3.3	0.4	0.3	-0.6	1.8	0.4
Pack years adult smoking proportion	0.6	0.9	1.8	-1.0	0.1	0.0	-1.4	-1.3
Supplements: Glucosamine	0.6	0.8	1.6	-0.7	-0.5	1.2	-0.8	-1.0
Leg predicted mass (left)	0.6	3.3	13.2	3.6	1.1	0.5	1.3	0.5
Qualifications: None of the above	0.6	1.2	2.7	-0.2	1.5	1.6	-1.1	0.2
Pulse rate	0.6	1.0	2.1	-1.5	-0.6	-0.4	-1.3	-0.7
Loud music exposure frequency	0.6	0.7	1.2	-0.9	-1.0	0.7	-0.1	-1.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.0	-0.9	-1.4	-0.8	-0.3	-0.9
Qualifications: nursing, teaching	0.6	0.9	2.3	0.5	-1.3	0.2	0.4	-1.5
Osteoporosis (self-reported)	0.6	0.8	1.8	0.7	0.1	0.7	-1.3	1.1
Cholesterol lowering medication	0.6	0.8	1.7	-1.1	-0.7	1.3	-0.6	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	3.8	0.0	0.2	0.5	-1.9	0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	1.5	1.2	0.6	-0.3	1.1	-0.8
Chronotype (morning person)	0.5	1.1	2.1	0.5	0.9	-1.2	1.1	1.4
Diabetes (mother)	0.5	0.6	1.8	-1.4	-0.5	-0.5	-0.4	-0.9
Stomach or abdominal pain in last month	0.5	0.7	1.7	-1.3	-1.2	0.4	0.1	0.3
Medication: Atenolol	0.5	0.7	2.0	-1.0	-1.4	0.2	0.2	-0.6
Had menopause	0.5	0.6	2.6	0.1	0.6	1.6	0.3	0.2
Heart attack	0.5	0.7	1.9	-0.9	0.3	-1.4	0.4	0.7
Worrier / anxious feelings	0.5	1.0	4.0	-0.3	0.3	0.8	-0.2	2.0
Medication: Cholesterol lowering	0.5	0.8	2.0	-0.0	0.7	-1.2	1.4	0.4
Body fat percentage	0.5	2.1	3.4	-1.8	-1.1	1.4	-1.4	-1.4
Medication: Seretide 50 evohaler	0.5	0.5	1.0	-0.6	-0.2	1.0	-0.9	0.6
Medication for cholesterol	0.5	0.7	3.4	0.1	0.3	-1.9	-0.1	0.1
Breast cancer (self-reported)	0.5	0.6	2.3	0.2	1.5	0.1	-0.2	0.6
Miserableness	0.5	0.9	3.1	1.0	0.0	0.4	-0.3	1.8
High cholesterol (Self-reported)	0.5	0.9	1.6	-1.2	-1.1	-0.7	0.6	-1.0
Bipolar Disorder or Schizophrenia	0.4	0.9	1.5	0.3	1.2	-1.2	-0.0	1.2
Major Depression (MDD)	0.4	0.5	1.1	-0.5	-0.5	1.0	-1.0	-0.2
Hypothyroidism (self reported)	0.4	0.9	3.1	1.8	0.2	0.9	0.4	-0.2
Townsend deprivation index at recruitment	0.4	0.6	2.0	0.4	0.8	1.4	0.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.2	0.1	-0.2	0.9	-0.1	1.1
Serious illness, injury or assault to yourself	0.4	0.5	1.1	0.1	0.0	-0.9	0.7	1.1
Multivitamins +/- minerals	0.4	0.5	2.2	0.6	0.2	0.1	-1.5	0.2
High blood pressure (mother)	0.4	0.6	1.1	-0.8	-0.9	-1.0	-0.4	0.2
Alcohol usually taken with meals	0.4	0.7	2.1	1.4	0.2	0.4	0.0	1.1
Had other major operations	0.4	0.4	1.2	0.7	0.6	0.3	-1.1	0.4
Medication: Ramipril	0.4	0.5	1.1	-0.5	-0.3	-1.0	-0.0	-1.1
Weight	0.4	1.8	6.8	2.6	0.8	1.0	0.8	0.1
Depression (self-reported)	0.4	0.5	0.8	0.9	0.0	0.9	0.7	0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.7	0.2	-0.6	1.3	0.3	0.6
Age at first live birth	0.4	0.8	1.4	-0.5	-0.9	-1.1	-0.6	-1.2
Heart disease (mother)	0.4	0.5	1.2	0.5	0.5	1.1	-0.1	0.8
Knee pain experienced in last month	0.4	0.6	1.2	-1.1	-0.7	0.6	-1.0	-0.2
Eye problems/disorders: Cataract	0.4	0.5	1.7	-0.5	-0.5	0.3	-1.3	-0.3
Risk taking	0.4	0.5	1.0	0.7	1.0	-0.6	-0.3	-0.8
Commuting to job workplace: Cycle	0.4	0.5	1.2	-0.3	-0.6	-0.6	1.1	-0.7
Supplements: Calcium	0.4	0.5	0.8	0.6	-0.7	0.8	-0.9	-0.2
Pack years of smoking	0.4	0.6	1.6	-0.6	0.5	0.3	-1.2	-1.0
Fasting Glucose	0.3	0.4	1.6	-1.3	0.2	0.0	-0.5	-0.2
HbA1C	0.3	0.4	1.4	-0.6	0.3	-1.2	0.2	-0.3
Schizophrenia (2014)	0.3	0.7	2.1	-1.4	-0.5	-0.7	-0.9	-0.1
Maternal smoking around birth	0.3	0.5	1.4	0.1	-0.8	0.4	-1.2	-0.5
Trunk fat mass	0.3	1.3	2.9	-0.7	-1.2	0.5	-1.2	-1.7
Medication: Simvastatin	0.3	0.5	1.4	0.0	0.9	0.3	1.2	0.2
Arm fat percentage (right)	0.3	1.0	3.5	-1.0	-0.2	1.9	-0.6	-0.6
Father’s age at death	0.3	0.3	1.2	1.1	-0.1	0.4	-0.5	-0.3
Mouth/teeth dental problems: Dentures	0.3	0.5	0.9	0.9	0.7	0.4	0.8	0.3
Birth weight	0.3	0.6	2.2	0.5	-0.2	-0.4	-0.2	1.5
Leg fat percentage (right)	0.3	1.2	3.5	-1.1	-0.2	1.9	-1.0	0.3
Alcohol intake frequency.	0.3	0.8	3.0	0.0	0.4	0.7	-0.6	1.7
Age at last live birth	0.3	0.4	0.7	0.7	-0.6	0.2	-0.8	-0.6
Arm fat percentage (left)	0.3	1.3	3.5	-1.2	-0.3	1.9	-0.7	-0.9
Loneliness, isolation	0.3	0.4	1.1	0.7	0.6	0.1	0.0	1.1
Diabetes diagnosed by doctor	0.3	0.5	1.6	-0.5	-0.6	-0.4	0.3	-1.2
Friendships satisfaction	0.3	0.3	1.6	0.1	-1.2	-0.1	0.2	0.1
Back pain experienced in last month	0.3	0.5	1.6	0.1	-0.2	0.5	-0.7	1.3
Guilty feelings	0.3	0.5	1.0	0.4	0.2	-0.8	-0.7	1.0
Medication: Bendroflumethiazide	0.3	0.5	1.8	-0.1	-1.3	-0.1	-0.4	-0.6
Alcohol drinker status: Never	0.3	0.3	1.1	-0.5	-0.1	0.6	-0.0	1.0
Leg fat percentage (left)	0.3	0.9	3.7	-0.7	0.2	1.9	-0.7	0.3
Schizophrenia (2018)	0.2	0.4	0.8	-0.7	0.1	-0.9	-0.7	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	-0.9	-0.6	-0.2	-0.7	-0.5
Lung FEV1/FVC ratio	0.2	1.1	2.7	-0.2	-0.3	-0.7	1.6	-1.6
Qualifications: CSEs or equivalent	0.2	0.2	0.8	-0.2	0.1	-0.3	0.9	0.2
Hip circumference	0.2	0.9	1.5	0.9	-0.3	1.1	-1.2	-1.1
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.7	0.2	-0.8	-0.5	-0.4
Happiness	0.2	0.2	0.6	0.0	-0.3	0.8	-0.2	0.5
Arm fat mass (right)	0.2	0.6	2.6	0.5	0.5	1.6	0.3	-0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.9	0.3	0.3	-0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	-0.2	-0.3	-0.3	0.4	0.8
Ever had bowel cancer screening	0.2	0.3	0.9	-0.2	0.7	0.9	-0.1	-0.2
Arm fat mass (left)	0.2	0.7	2.9	0.5	0.5	1.7	0.2	-0.1
Ever taken oral contraceptive pill	0.2	0.2	0.8	0.9	0.2	0.1	-0.3	0.5
Leg fat mass (left)	0.2	0.9	3.7	0.6	0.5	1.9	0.1	0.2
Rheumatoid Arthritis	0.1	0.1	0.4	-0.0	-0.1	0.5	0.0	0.7
Hair Pigment	0.1	2.0	3.0	-1.1	-1.4	-1.7	-1.0	-1.6
Tanning	0.1	1.5	5.7	-0.7	-0.6	-0.4	1.0	-2.4
Diabetes (self-reported)	0.1	0.1	0.5	0.2	0.1	0.3	0.7	-0.2
Illnesses of mother	0.1	0.1	0.4	0.2	0.3	0.1	0.7	0.3
Whole body fat mass	0.1	0.5	1.6	-0.1	-0.4	1.3	-0.6	-0.7
Leg fat mass (right)	0.1	0.5	2.5	0.2	0.1	1.6	-0.3	0.1
Medication: Gliclazide	0.1	0.2	0.5	-0.1	-0.1	-0.4	-0.3	0.7
Hearing aid user	0.1	0.1	0.1	0.3	-0.2	-0.3	0.3	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

MGC57346

Models

Trait associations