[Hub]/) : Traits : Impedance of leg (right) : ← →

chr2:197,560,575-201,490,349

Best TWAS P=1.18e-20 · Best GWAS P=4.33e-22 conditioned to 0.0312

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Skin Sun Exposed Lower leg	MARS2	0.04	0.05	enet	8	0.03	1.2e-03	9.19	-9.3	1.2e-20	-0.86	0.10	0.90	TRUE
14	GTEx	Testis	C2orf69	0.14	0.09	enet	17	0.10	2.7e-05	4.03	5.2	2.4e-07	0.11	0.33	0.46	TRUE
18	GTEx	Whole Blood	PLCL1	0.08	0.08	enet	15	0.05	4.1e-05	9.38	9.3	1.9e-20	0.92	0.07	0.93	FALSE
10	GTEx	Lung	RFTN2	0.06	0.08	lasso	8	0.06	2.7e-05	9.36	9.1	1.1e-19	0.86	0.08	0.91	FALSE
12	GTEx	Spleen	RFTN2	0.11	0.03	enet	26	0.05	2.4e-02	9.13	8.9	7.0e-19	0.84	0.07	0.49	FALSE
17	GTEx	Thyroid	RFTN2	0.04	0.01	enet	11	0.01	9.5e-02	9.14	8.7	3.0e-18	0.80	0.12	0.65	FALSE
13	GTEx	Spleen	MARS2	0.12	0.04	lasso	5	0.00	3.4e-01	9.16	-8.7	4.3e-18	-0.82	0.07	0.37	FALSE
2	GTEx	Adipose Subcutaneous	RFTN2	0.14	0.10	enet	11	0.13	5.3e-11	9.07	8.5	1.7e-17	0.86	0.13	0.87	FALSE
16	GTEx	Thyroid	PLCL1	0.04	0.01	lasso	4	0.00	2.6e-01	8.99	8.0	1.3e-15	0.76	0.20	0.50	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	HSPD1	0.15	0.04	lasso	7	0.04	2.0e-02	6.12	-7.7	1.0e-14	-0.64	0.10	0.62	FALSE
22	YFS	Blood	PLCL1	0.10	0.10	lasso	9	0.14	1.5e-43	9.23	7.7	1.2e-14	0.83	0.12	0.88	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	MARS2	0.05	0.03	enet	14	0.05	2.2e-07	-6.16	-7.7	1.3e-14	-0.75	0.13	0.86	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLCL1	0.04	0.00	blup	130	0.02	4.0e-03	-0.53	7.7	1.7e-14	0.65	0.05	0.40	FALSE
19	METSIM	Adipose	PLCL1	0.06	0.01	blup	517	0.05	3.6e-08	-2.19	7.5	8.9e-14	0.73	0.12	0.88	FALSE
15	GTEx	Thyroid	SF3B1	0.04	0.02	enet	14	0.02	2.0e-02	4.78	6.9	4.8e-12	0.72	0.08	0.86	FALSE
20	NTR	Blood	PLCL1	0.02	0.01	enet	14	0.02	1.9e-06	9.36	6.8	1.2e-11	0.72	0.05	0.93	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFTN2	0.05	0.01	blup	61	0.02	3.1e-02	3.88	6.8	1.2e-11	0.70	0.04	0.38	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MOBKL3	0.03	0.01	blup	32	0.02	6.3e-03	7.29	6.7	1.9e-11	0.63	0.01	0.50	FALSE
5	GTEx	Breast Mammary Tissue (Female)	SF3B1	0.05	-0.01	lasso	3	-0.01	8.1e-01	3.77	6.2	4.4e-10	0.65	0.05	0.08	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	MARS2	0.15	0.14	lasso	4	0.07	2.6e-03	-6.45	-6.2	7.7e-10	-0.63	0.07	0.61	FALSE
8	GTEx	Colon Transverse	MARS2	0.17	0.12	lasso	4	0.13	7.4e-07	-6.45	-5.9	3.8e-09	-0.59	0.26	0.39	FALSE
3	GTEx	Brain Frontal Cortex BA9	MARS2	0.18	0.12	lasso	2	0.07	5.1e-03	5.61	-5.6	2.0e-08	-0.47	0.14	0.07	FALSE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	RFTN2	0.02	0.02	lasso	2	0.01	1.1e-03	5.76	5.6	2.2e-08	0.45	0.22	0.25	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HSPD1	0.08	0.09	lasso	7	0.09	2.2e-11	5.74	5.5	2.8e-08	0.45	1.00	0.00	FALSE
9	GTEx	Esophagus Muscularis	SF3B1	0.06	0.02	lasso	4	0.03	1.0e-02	4.92	5.5	4.4e-08	0.41	0.18	0.15	FALSE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	RFTN2	0.15	0.10	lasso	1	0.08	2.3e-03	5.42	5.4	6.0e-08	0.44	0.04	0.35	FALSE
4	GTEx	Breast Mammary Tissue	SF3B1	0.06	0.06	lasso	4	0.03	6.6e-03	3.77	5.4	7.1e-08	0.61	0.19	0.64	FALSE