[Hub]/) : Traits : Impedance of leg (right) :

chr2:197,560,575-201,490,349

Best TWAS P=1.18e-20 · Best GWAS P=4.33e-22 conditioned to 0.0312

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HSPD1 0.08 0.09 lasso 7 0.09 2.2e-11 5.74 5.5 2.8e-08 0.45 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous RFTN2 0.14 0.10 enet 11 0.13 5.3e-11 9.07 8.5 1.7e-17 0.86 0.13 0.87 FALSE
3 GTEx Brain Frontal Cortex BA9 MARS2 0.18 0.12 lasso 2 0.07 5.1e-03 5.61 -5.6 2.0e-08 -0.47 0.14 0.07 FALSE
4 GTEx Breast Mammary Tissue SF3B1 0.06 0.06 lasso 4 0.03 6.6e-03 3.77 5.4 7.1e-08 0.61 0.19 0.64 FALSE
5 GTEx Breast Mammary Tissue (Female) SF3B1 0.05 -0.01 lasso 3 -0.01 8.1e-01 3.77 6.2 4.4e-10 0.65 0.05 0.08 FALSE
6 GTEx Cells EBV-transformed lymphocytes HSPD1 0.15 0.04 lasso 7 0.04 2.0e-02 6.12 -7.7 1.0e-14 -0.64 0.10 0.62 FALSE
7 GTEx Cells EBV-transformed lymphocytes MARS2 0.15 0.14 lasso 4 0.07 2.6e-03 -6.45 -6.2 7.7e-10 -0.63 0.07 0.61 FALSE
8 GTEx Colon Transverse MARS2 0.17 0.12 lasso 4 0.13 7.4e-07 -6.45 -5.9 3.8e-09 -0.59 0.26 0.39 FALSE
9 GTEx Esophagus Muscularis SF3B1 0.06 0.02 lasso 4 0.03 1.0e-02 4.92 5.5 4.4e-08 0.41 0.18 0.15 FALSE
10 GTEx Lung RFTN2 0.06 0.08 lasso 8 0.06 2.7e-05 9.36 9.1 1.1e-19 0.86 0.08 0.91 FALSE
11 GTEx Skin Sun Exposed Lower leg MARS2 0.04 0.05 enet 8 0.03 1.2e-03 9.19 -9.3 1.2e-20 -0.86 0.10 0.90 TRUE
12 GTEx Spleen RFTN2 0.11 0.03 enet 26 0.05 2.4e-02 9.13 8.9 7.0e-19 0.84 0.07 0.49 FALSE
13 GTEx Spleen MARS2 0.12 0.04 lasso 5 0.00 3.4e-01 9.16 -8.7 4.3e-18 -0.82 0.07 0.37 FALSE
14 GTEx Testis C2orf69 0.14 0.09 enet 17 0.10 2.7e-05 4.03 5.2 2.4e-07 0.11 0.33 0.46 TRUE
15 GTEx Thyroid SF3B1 0.04 0.02 enet 14 0.02 2.0e-02 4.78 6.9 4.8e-12 0.72 0.08 0.86 FALSE
16 GTEx Thyroid PLCL1 0.04 0.01 lasso 4 0.00 2.6e-01 8.99 8.0 1.3e-15 0.76 0.20 0.50 FALSE
17 GTEx Thyroid RFTN2 0.04 0.01 enet 11 0.01 9.5e-02 9.14 8.7 3.0e-18 0.80 0.12 0.65 FALSE
18 GTEx Whole Blood PLCL1 0.08 0.08 enet 15 0.05 4.1e-05 9.38 9.3 1.9e-20 0.92 0.07 0.93 FALSE
19 METSIM Adipose PLCL1 0.06 0.01 blup 517 0.05 3.6e-08 -2.19 7.5 8.9e-14 0.73 0.12 0.88 FALSE
20 NTR Blood PLCL1 0.02 0.01 enet 14 0.02 1.9e-06 9.36 6.8 1.2e-11 0.72 0.05 0.93 FALSE
21 ROSMAP Brain Pre-frontal Cortex MARS2 0.05 0.03 enet 14 0.05 2.2e-07 -6.16 -7.7 1.3e-14 -0.75 0.13 0.86 FALSE
22 YFS Blood PLCL1 0.10 0.10 lasso 9 0.14 1.5e-43 9.23 7.7 1.2e-14 0.83 0.12 0.88 FALSE
23 The Cancer Genome Atlas Breast Invasive Carcinoma RFTN2 0.02 0.02 lasso 2 0.01 1.1e-03 5.76 5.6 2.2e-08 0.45 0.22 0.25 FALSE
24 The Cancer Genome Atlas Glioblastoma Multiforme RFTN2 0.15 0.10 lasso 1 0.08 2.3e-03 5.42 5.4 6.0e-08 0.44 0.04 0.35 FALSE
25 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PLCL1 0.04 0.00 blup 130 0.02 4.0e-03 -0.53 7.7 1.7e-14 0.65 0.05 0.40 FALSE
26 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MOBKL3 0.03 0.01 blup 32 0.02 6.3e-03 7.29 6.7 1.9e-11 0.63 0.01 0.50 FALSE
27 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RFTN2 0.05 0.01 blup 61 0.02 3.1e-02 3.88 6.8 1.2e-11 0.70 0.04 0.38 FALSE