[Hub]/) : Traits : Impedance of leg (right) : ← →

chr4:24,470,143-27,132,182

Best TWAS P=4.24e-11 · Best GWAS P=5.06e-12 conditioned to 2.26e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Brain Cortex	ANAPC4	0.33	0.24	enet	23	0.26	7.5e-08	-6.0	-6.6	4.2e-11	0.06	0.02	0.98	TRUE
34	ROSMAP	Brain Pre-frontal Cortex	RBPJ	0.10	0.02	bslmm	469	0.05	5.3e-07	4.0	6.5	5.6e-11	0.48	0.07	0.92	TRUE
24	GTEx	Pituitary	ANAPC4	0.38	0.12	lasso	7	0.07	8.8e-03	-6.3	-6.4	1.3e-10	0.04	0.02	0.92	FALSE
3	GTEx	Artery Tibial	ANAPC4	0.37	0.42	enet	48	0.46	1.0e-39	-6.0	-6.4	1.7e-10	0.08	0.08	0.92	FALSE
23	GTEx	Pancreas	ANAPC4	0.35	0.21	lasso	13	0.19	1.8e-08	-6.0	-6.4	1.9e-10	0.08	0.03	0.97	FALSE
8	GTEx	Breast Mammary Tissue	ANAPC4	0.49	0.42	lasso	8	0.42	1.5e-23	-6.0	-6.3	2.5e-10	0.04	0.08	0.92	FALSE
11	GTEx	Colon Sigmoid	ANAPC4	0.28	0.27	enet	12	0.24	5.7e-09	-6.0	-6.3	2.5e-10	0.06	0.05	0.95	FALSE
16	GTEx	Esophagus Muscularis	ANAPC4	0.37	0.40	lasso	8	0.39	2.4e-25	-6.0	-6.3	3.1e-10	0.04	0.05	0.95	FALSE
21	GTEx	Muscle Skeletal	ZCCHC4	0.13	0.11	lasso	4	0.11	2.7e-11	-6.0	-6.3	3.5e-10	0.05	0.08	0.92	FALSE
31	GTEx	Thyroid	ANAPC4	0.27	0.23	lasso	14	0.26	8.0e-20	-6.0	-6.2	5.8e-10	0.07	0.04	0.96	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	ANAPC4	0.26	0.22	enet	21	0.20	8.3e-08	-6.0	-6.2	6.8e-10	0.07	0.02	0.98	FALSE
1	GTEx	Adipose Subcutaneous	ANAPC4	0.32	0.40	lasso	13	0.40	7.3e-35	-6.0	-6.1	8.2e-10	0.05	0.03	0.97	FALSE
20	GTEx	Lung	ANAPC4	0.14	0.14	enet	11	0.13	4.4e-10	-6.0	-6.1	8.2e-10	0.05	0.04	0.96	FALSE
29	GTEx	Stomach	ANAPC4	0.28	0.34	lasso	5	0.32	5.1e-16	-6.0	-6.1	8.4e-10	0.05	0.05	0.95	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	ANAPC4	0.19	0.27	lasso	11	0.27	3.5e-35	-6.0	-6.1	1.0e-09	0.06	0.05	0.95	FALSE
9	GTEx	Breast Mammary Tissue (Female)	ANAPC4	0.30	0.28	lasso	8	0.19	2.2e-06	-6.0	-6.1	1.2e-09	0.05	0.05	0.95	FALSE
18	GTEx	Heart Left Ventricle	ANAPC4	0.13	0.10	lasso	7	0.07	1.6e-04	-6.3	-6.1	1.2e-09	0.04	0.01	0.98	FALSE
10	GTEx	Cells Transformed fibroblasts	ANAPC4	0.14	0.20	lasso	8	0.19	2.3e-14	-6.0	-6.1	1.3e-09	0.04	0.02	0.98	FALSE
2	GTEx	Artery Aorta	ANAPC4	0.40	0.43	lasso	5	0.42	5.4e-25	-6.0	-6.0	1.6e-09	0.04	0.06	0.94	FALSE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ANAPC4	0.10	0.04	lasso	5	0.06	1.1e-03	-5.9	-6.0	1.9e-09	0.04	0.03	0.66	FALSE
27	GTEx	Skin Sun Exposed Lower leg	ANAPC4	0.27	0.34	enet	23	0.34	4.4e-29	-6.0	-6.0	2.1e-09	0.05	0.07	0.93	FALSE
30	GTEx	Testis	ANAPC4	0.12	0.10	lasso	5	0.08	2.3e-04	-6.0	-6.0	2.1e-09	0.05	0.03	0.95	FALSE
17	GTEx	Heart Atrial Appendage	ANAPC4	0.18	0.12	lasso	9	0.10	3.4e-05	-6.0	-5.9	3.2e-09	0.04	0.01	0.99	FALSE
28	GTEx	Spleen	ANAPC4	0.41	0.28	enet	14	0.36	3.2e-10	-5.2	-5.9	3.2e-09	0.02	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	ZCCHC4	0.07	0.06	enet	12	0.09	1.7e-09	-6.1	-5.9	4.1e-09	0.05	0.06	0.94	FALSE
14	GTEx	Esophagus Mucosa	ANAPC4	0.33	0.23	lasso	10	0.21	4.6e-14	-6.0	-5.9	4.3e-09	0.04	0.03	0.97	FALSE
22	GTEx	Nerve Tibial	ANAPC4	0.35	0.43	enet	14	0.43	4.3e-33	-6.0	-5.8	5.0e-09	0.04	0.08	0.92	FALSE
12	GTEx	Colon Transverse	ANAPC4	0.36	0.38	lasso	8	0.41	5.5e-21	-6.0	-5.8	5.5e-09	0.05	0.05	0.95	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	ANAPC4	0.40	0.45	enet	28	0.44	1.5e-26	-6.0	-5.8	6.4e-09	0.05	0.08	0.92	FALSE
15	GTEx	Esophagus Muscularis	PI4K2B	0.14	0.05	lasso	7	0.05	4.2e-04	-4.9	-5.7	1.0e-08	0.07	0.38	0.57	FALSE
25	GTEx	Prostate	ANAPC4	0.28	0.12	enet	11	0.12	5.2e-04	-6.0	-5.6	1.8e-08	0.03	0.02	0.94	FALSE
7	GTEx	Brain Putamen basal ganglia	ANAPC4	0.25	0.03	lasso	7	0.04	3.6e-02	-6.2	-5.6	2.2e-08	0.05	0.05	0.60	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANAPC4	0.03	0.05	enet	10	0.04	1.9e-05	-6.0	-5.6	2.2e-08	0.03	0.02	0.97	FALSE
19	GTEx	Liver	ANAPC4	0.25	0.14	enet	16	0.02	1.1e-01	-6.0	-5.6	2.6e-08	0.07	0.02	0.89	FALSE
32	METSIM	Adipose	ANAPC4	0.19	0.28	bslmm	552	0.28	3.5e-42	-6.0	-5.5	3.5e-08	0.05	0.04	0.96	FALSE
6	GTEx	Brain Nucleus accumbens basal ganglia	ANAPC4	0.41	0.15	enet	30	0.20	4.2e-06	-6.2	-5.5	4.0e-08	0.01	0.05	0.93	FALSE
35	YFS	Blood	ANAPC4	0.22	0.28	bslmm	530	0.32	4.5e-109	-6.0	-5.5	5.2e-08	0.06	0.08	0.92	FALSE
39	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ANAPC4	0.05	0.00	blup	69	0.01	7.5e-03	-5.9	-5.4	6.2e-08	0.03	0.01	0.95	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZCCHC4	0.02	0.01	blup	83	0.00	4.5e-02	-6.0	-5.4	6.9e-08	0.06	0.06	0.90	FALSE
4	GTEx	Brain Caudate basal ganglia	ANAPC4	0.35	0.10	lasso	8	0.04	2.2e-02	-3.2	-5.2	1.6e-07	0.08	0.12	0.79	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZCCHC4	0.08	0.06	enet	13	0.08	3.4e-09	-6.0	-5.2	1.7e-07	0.07	0.11	0.89	FALSE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ANAPC4	0.14	0.12	enet	11	0.09	4.5e-06	-6.0	-5.2	1.9e-07	-0.02	0.04	0.96	FALSE