TWAS hub - ZCCHC4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0680	0.0240	5.7e-04	0.010	0.017	0.012	0.015	0.013	1.9e-02	3.1e-03	1.3e-02	0.0057	8.0e-03
2	GTEx	Adrenal Gland	0.2863	0.0918	1.7e-03	-0.007	NA	0.000	NA	-0.008	7.3e-01	NA	3.3e-01	NA	9.7e-01
3	GTEx	Artery Aorta	0.1470	0.0620	9.8e-03	0.016	NA	-0.004	NA	0.014	4.1e-02	NA	6.7e-01	NA	5.3e-02
4	GTEx	Cells EBV-transformed lymphocytes	0.3760	0.0890	1.8e-05	0.132	NA	0.084	NA	0.120	4.5e-05	NA	1.1e-03	NA	1.0e-04
5	GTEx	Cells Transformed fibroblasts	0.1280	0.0380	1.1e-04	0.025	NA	0.051	NA	0.049	5.1e-03	NA	1.0e-04	NA	1.5e-04
6	GTEx	Muscle Skeletal	0.1326	0.0338	1.0e-08	0.110	NA	0.103	NA	0.114	7.0e-11	NA	2.7e-10	NA	2.7e-11
7	GTEx	Testis	0.1410	0.0540	5.0e-03	0.114	NA	0.045	NA	0.055	9.9e-06	NA	4.7e-03	NA	1.9e-03
8	ROSMAP	Brain Pre-frontal Cortex	0.0371	0.0180	1.7e-02	0.006	0.010	0.008	0.008	0.006	5.3e-02	1.8e-02	3.0e-02	0.0260	5.2e-02
9	TCGA	Breast Invasive Carcinoma	0.0194	0.0107	3.1e-04	0.010	0.004	0.004	NA	0.001	2.8e-03	4.5e-02	5.2e-02	NA	1.8e-01
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0929	0.0409	9.8e-06	0.016	0.050	0.051	NA	0.022	5.5e-03	2.4e-06	2.1e-06	NA	1.3e-03
11	TCGA	Lung Adenocarcinoma	0.0669	0.0328	5.0e-06	0.016	0.048	0.044	NA	0.032	5.0e-03	2.6e-06	5.9e-06	NA	1.0e-04
12	TCGA	Prostate Adenocarcinoma	0.0847	0.0328	2.3e-09	0.058	0.075	0.085	NA	0.060	1.1e-06	2.7e-08	3.4e-09	NA	7.1e-07
13	TCGA	Thyroid Carcinoma	0.0700	0.0280	1.9e-08	0.064	0.084	0.095	NA	0.090	8.3e-07	1.5e-08	1.7e-09	NA	4.5e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Impedance of arm (left)	7.9	36.7	52.3	-6.2	-4.7	-4.5	-7.2	-6.4	-6.7	-5.3	-6.4	-7.2	-5.0	-6.1	-6.1	-6.3
Impedance of arm (right)	7.6	35.6	51.8	-5.8	-4.3	-4.7	-7.2	-6.3	-6.3	-5.6	-6.8	-7.0	-4.9	-5.9	-6.0	-5.8
Medication: Lisinopril	7.3	9.5	16.6	2.7	1.3	2.0	3.6	3.1	3.8	1.9	2.9	3.9	2.5	3.3	3.6	4.1
Medication: Ibuprofen	7.0	8.4	13.3	2.0	3.2	2.6	2.7	2.6	3.3	3.6	2.7	3.1	1.3	3.2	3.5	2.9
Ever had stillbirth, spontaneous miscarriage or termination	6.8	7.3	12.8	3.1	0.4	2.9	3.6	2.4	2.9	2.6	3.4	2.8	1.7	2.5	2.8	2.6
Impedance of whole body	6.7	34.2	51.1	-5.8	-4.6	-3.6	-6.6	-6.0	-7.1	-5.0	-5.9	-7.0	-4.6	-5.6	-6.3	-6.7
Pain type(s) experienced in last month: Hip pain	6.5	8.3	11.5	2.9	3.1	2.1	3.1	2.8	3.1	2.4	3.4	3.3	2.5	2.6	2.7	3.1
Medication for hormone replacement therapy	4.8	5.4	10.0	2.1	0.1	2.2	2.0	1.4	3.1	2.1	0.8	2.7	2.5	2.8	3.2	3.0
BMI	4.4	25.6	36.6	5.5	4.9	2.9	5.7	5.2	6.0	4.3	5.0	5.7	3.1	5.1	5.1	6.0
Body mass index (BMI)	4.4	18.6	30.5	4.8	4.6	2.2	4.8	4.0	5.5	4.1	4.4	4.9	2.6	3.6	4.3	5.0
Long-standing illness, disability or infirmity	4.4	6.7	13.2	1.9	3.4	0.4	2.8	2.4	2.6	-0.3	2.3	3.4	3.6	2.2	2.5	3.4
Impedance of leg (left)	4.3	21.1	43.2	-4.1	-4.1	-1.4	-4.7	-4.4	-6.6	-3.1	-4.3	-5.5	-3.4	-3.9	-5.4	-6.3
Risk taking	4.2	6.1	12.6	2.1	1.8	1.4	2.4	1.3	3.5	1.3	1.7	3.2	2.8	2.4	3.0	3.5
Vascular/heart problems diagnosed by doctor	4.2	11.5	17.7	-2.1	-3.8	-2.3	-3.6	-3.1	-4.2	-3.0	-3.9	-4.0	-2.2	-3.3	-3.8	-3.9
Impedance of leg (right)	4.1	19.8	39.4	-3.9	-3.9	-1.4	-4.7	-4.3	-6.3	-3.0	-4.4	-5.4	-3.5	-3.8	-5.2	-5.9
Comparative body size at age 10	4.0	10.9	16.2	3.8	0.9	2.9	4.0	3.9	3.4	3.3	3.3	3.9	2.5	3.3	3.3	3.2
Medication: Ibuprofen (e.g. Nurofen)	3.9	5.0	8.6	2.0	2.6	1.5	2.1	1.6	2.9	2.7	1.9	2.4	0.7	2.3	2.9	2.5
Hypertension (Self-reported)	3.8	10.5	16.6	2.1	3.2	2.4	3.6	3.2	3.6	2.5	3.9	4.1	2.1	3.3	3.5	3.6
Body Mass Index (BMI) (2010)	3.7	5.1	8.9	2.0	1.8	1.0	3.0	2.2	2.5	2.1	3.0	2.4	1.9	2.2	2.1	2.5
Nervous feelings	3.7	6.9	13.0	-2.0	-1.0	-1.7	-3.3	-2.6	-2.6	-1.4	-3.1	-3.6	-2.6	-2.8	-3.1	-2.8
Cardiovascular Disease	3.6	11.8	18.0	3.1	3.2	3.5	3.9	3.5	3.4	4.2	3.4	3.6	1.5	4.0	3.4	3.2
Illnesses of father: None of the above (group 1)	3.6	4.4	8.1	-1.1	-0.0	-2.9	-2.5	-2.2	-1.9	-2.2	-2.2	-2.5	-1.0	-2.8	-2.3	-1.8
Type 2 Diabetes (T2D) (2018)	3.5	6.6	10.8	3.0	-0.2	1.8	3.3	2.7	2.1	1.1	2.9	2.8	3.2	3.1	2.5	2.8
Arm fat-free mass (left)	3.5	17.6	26.5	4.7	2.7	3.8	5.0	4.5	4.5	5.2	4.8	4.4	2.6	4.0	4.1	3.7
Myopia	3.5	5.0	8.4	-2.9	-2.8	-1.4	-2.4	-2.8	-2.5	-1.7	-1.4	-2.3	-1.6	-2.1	-2.1	-2.4
Arm predicted mass (left)	3.5	17.7	25.9	4.7	2.8	3.5	4.9	4.3	4.7	5.1	4.8	4.4	2.7	4.0	4.2	3.9
Worry (Nagel 2018)	3.3	6.9	14.4	-2.3	-1.5	-2.0	-3.3	-2.9	-2.0	-2.0	-3.8	-3.4	-2.2	-2.8	-2.7	-2.1
High blood pressure	3.3	9.2	13.9	2.0	3.5	2.3	3.3	3.0	3.4	2.8	3.7	3.5	1.8	3.0	3.2	3.2
High blood pressure (siblings)	3.3	4.7	10.1	1.7	3.2	2.0	1.8	2.0	2.9	2.3	1.9	2.0	0.3	2.1	2.3	2.5
Arm predicted mass (right)	3.2	16.3	27.8	4.2	2.4	3.8	4.7	4.1	4.3	5.3	4.7	4.0	2.4	3.9	4.2	3.5
Suffer from ‘nerves’	3.2	5.1	8.8	-1.0	-1.8	-2.1	-2.4	-2.3	-2.2	-1.9	-2.4	-3.0	-2.2	-2.5	-2.6	-2.2
Knee pain experienced in last month	3.2	4.9	8.2	1.9	1.7	1.5	2.6	2.0	2.9	2.2	2.7	2.8	2.0	1.7	1.8	2.5
Pulse rate	3.0	5.1	15.5	3.0	1.0	2.0	2.6	1.6	2.3	3.9	2.6	2.0	0.4	1.8	2.6	1.3
Medication for cholesterol	3.0	4.5	8.5	-1.5	-1.1	-1.2	-2.1	-1.9	-2.9	-1.7	-1.5	-2.8	-1.7	-2.5	-2.6	-2.9
Illnesses of father: High blood pressure	2.9	3.5	5.8	1.7	-1.2	2.2	1.7	1.6	2.3	2.2	1.1	2.3	1.1	2.0	2.4	1.9
Financial difficulties in last 2 years	2.7	3.6	8.8	1.6	1.3	0.3	1.7	1.5	3.0	0.8	1.1	2.3	2.1	1.7	2.3	3.0
Arm fat-free mass (right)	2.7	14.1	22.5	4.0	2.0	3.5	4.4	3.9	3.9	4.7	4.5	3.8	2.4	3.6	3.7	3.2
Medication for pain relief, constipation, heartburn	2.7	4.6	8.8	-1.9	-2.7	-0.5	-2.4	-1.8	-2.4	-0.5	-2.0	-3.0	-1.2	-2.2	-2.4	-2.9
Number of self-reported non-cancer illnesses	2.7	4.7	10.6	1.5	1.4	-0.2	2.0	1.5	3.0	0.2	2.5	3.2	2.3	1.7	2.5	3.2
Intelligence (Savage-Jansen 2018)	2.6	8.0	17.7	-3.8	-3.3	-0.6	-2.6	-1.9	-4.2	-1.7	-2.1	-3.3	-0.5	-2.6	-2.9	-4.1
Angina	2.6	3.5	6.5	0.9	2.1	1.3	2.2	2.0	2.6	1.9	1.4	1.8	1.2	1.8	2.1	2.3
Ever had bowel cancer screening	2.6	3.0	9.5	0.4	0.8	-0.6	1.7	0.8	2.0	-0.8	2.2	2.5	3.1	1.2	1.4	2.5
Number of operations (self-reported)	2.6	3.9	7.9	1.3	0.8	-0.6	2.7	1.3	2.1	-0.4	2.5	2.8	2.4	1.6	1.9	2.7
Leg fat mass (left)	2.6	10.2	14.4	3.7	3.5	2.2	3.7	2.9	3.7	3.8	3.5	3.2	1.6	2.6	3.0	3.1
Primary Biliary Cirrhosis	2.5	3.5	6.3	0.4	1.8	1.7	2.0	1.9	2.5	2.3	1.4	2.1	1.5	1.7	2.2	2.0
Type 2 Diabetes (T2D) (2012)	2.5	2.9	8.6	0.8	2.7	1.6	1.7	2.1	1.4	2.9	2.1	1.6	0.1	1.0	1.0	0.6
Ever unenthusiastic/disinterested for a whole week	2.5	3.1	8.3	1.3	1.3	-0.1	1.5	1.9	2.9	1.1	0.7	2.1	1.7	1.4	2.3	2.5
Angina (self-reported)	2.5	3.3	6.6	0.8	2.2	1.2	2.0	1.9	2.6	1.8	1.2	1.7	1.1	1.8	2.1	2.3
Alcohol intake frequency.	2.5	5.7	9.5	2.7	2.4	0.9	2.9	2.7	2.4	2.2	3.1	3.1	1.4	1.8	2.3	2.1
Crohns Disease (2012)	2.4	3.9	7.4	2.0	1.2	1.7	2.0	1.7	2.3	2.3	2.7	2.4	-0.1	1.6	2.3	1.9
Leg fat mass (right)	2.4	9.5	13.1	3.6	3.2	2.1	3.6	2.8	3.6	3.6	3.5	3.1	1.6	2.5	2.8	3.1
Chest pain or discomfort	2.4	3.4	6.1	2.0	0.8	1.4	1.9	2.5	2.5	1.2	1.2	2.1	1.5	1.7	1.9	2.4
Illness, injury, bereavement, stress in last 2 years	2.4	3.0	10.3	-1.5	-1.2	1.1	-1.2	-0.2	-2.9	1.0	-1.1	-1.8	-2.4	-0.6	-1.5	-3.2
Hearing aid user	2.4	2.7	7.6	1.6	2.7	-0.4	1.6	1.7	1.0	-1.3	1.5	1.9	1.8	1.4	1.2	1.9
Medication: Paracetamol	2.4	3.8	7.3	1.0	2.4	-0.0	2.1	2.4	2.1	0.3	2.5	2.7	1.9	1.6	1.6	2.4
Sensitivity / hurt feelings	2.3	4.0	6.0	-1.8	-0.2	-1.5	-2.3	-2.3	-1.6	-0.7	-2.4	-2.4	-2.4	-2.4	-2.0	-2.2
Weight	2.3	11.4	17.4	3.8	3.0	2.2	3.7	3.2	4.2	3.9	3.9	3.5	1.9	2.9	3.5	3.6
Overall health rating	2.3	4.8	10.5	2.5	1.6	1.2	2.6	1.1	3.2	2.3	2.1	2.5	1.3	1.9	1.9	3.1
Whole body water mass	2.3	13.2	19.9	4.1	2.0	3.1	4.2	3.8	4.1	4.5	4.0	3.7	2.3	3.4	3.8	3.4
Basal metabolic rate	2.3	12.6	19.6	4.0	2.4	3.0	4.1	3.7	4.0	4.4	4.0	3.5	2.0	3.2	3.6	3.3
Diastolic blood pressure, automated reading	2.3	7.1	14.2	2.4	2.6	2.6	3.1	2.9	2.3	3.4	3.8	2.7	1.9	2.5	1.6	2.0
Whole body fat-free mass	2.2	12.8	19.6	4.0	2.0	3.1	4.1	3.8	4.0	4.4	4.0	3.6	2.3	3.3	3.7	3.3
Leg fat percentage (left)	2.2	7.8	11.9	3.5	3.1	2.0	3.4	2.6	2.9	3.0	3.3	3.0	1.7	2.4	2.4	2.6
Heart attack/myocardial infarction (self-reported)	2.2	2.9	5.2	0.6	1.0	1.5	2.1	1.7	2.1	1.6	1.6	2.3	1.2	1.8	2.0	1.8
Prostate Cancer	2.1	3.0	4.6	0.2	2.2	0.6	2.1	1.8	1.9	1.6	2.0	2.0	1.4	1.8	1.9	1.7
Leg predicted mass (left)	2.1	11.0	20.3	3.6	2.6	1.9	3.6	3.2	4.5	3.9	3.5	3.4	1.7	2.7	3.7	3.7
Trunk predicted mass	2.1	11.9	18.7	4.0	1.4	3.4	4.1	3.8	3.4	4.3	3.9	3.5	2.4	3.5	3.5	2.9
Leg fat percentage (right)	2.1	7.6	12.1	3.5	3.0	2.0	3.2	2.5	2.9	3.0	3.1	2.9	1.6	2.4	2.4	2.7
Worry too long after embarrassment	2.1	3.6	6.2	-0.6	-0.6	-0.9	-2.3	-1.6	-1.9	-1.0	-2.4	-2.5	-2.1	-2.3	-2.3	-2.3
Medication: Omeprazole	2.1	2.5	5.5	1.7	2.3	-0.7	1.7	0.2	2.1	0.5	1.2	1.9	1.7	1.1	1.7	2.1
Osteoarthritis (self-reported)	2.1	2.8	5.0	1.0	2.0	0.1	1.7	1.6	2.2	1.7	1.5	2.1	1.9	1.0	1.8	1.8
Leg predicted mass (right)	2.1	11.4	19.5	3.6	2.5	2.1	3.8	3.4	4.4	3.9	3.8	3.5	1.9	2.7	3.7	3.6
Arm fat mass (left)	2.1	8.5	13.2	3.6	3.1	1.8	3.2	2.5	3.6	3.5	3.1	2.9	1.1	2.3	2.9	3.0
Leg fat-free mass (left)	2.0	10.8	19.3	3.6	2.5	2.0	3.6	3.2	4.4	3.9	3.4	3.3	1.8	2.7	3.6	3.6
Diabetes (self-reported)	2.0	3.0	5.2	1.6	0.7	0.5	1.6	2.3	1.9	-0.1	1.6	2.3	2.2	1.7	2.0	2.3
Trunk fat-free mass	2.0	11.7	17.6	3.9	1.4	3.4	4.1	3.8	3.3	4.2	3.9	3.4	2.4	3.4	3.4	2.9
Arm fat mass (right)	2.0	8.4	14.0	3.7	3.5	1.5	3.1	2.5	3.7	3.2	2.8	2.9	1.1	2.2	2.9	3.2
Medication: Blood pressure	2.0	3.4	6.2	1.9	1.3	2.1	2.0	1.4	1.7	2.1	2.5	2.0	0.9	1.8	2.3	1.5
Leg fat-free mass (right)	2.0	10.8	19.1	3.5	2.5	2.0	3.7	3.3	4.4	3.7	3.6	3.4	1.9	2.6	3.6	3.6
Medication: Blood pressure	2.0	3.8	7.7	1.0	2.7	-0.0	1.7	1.8	2.7	1.2	1.8	2.5	1.1	1.9	2.1	2.8
Pain experienced in last month	2.0	3.4	7.5	-2.5	-1.3	-1.6	-2.7	-1.4	-1.6	-2.0	-2.6	-1.9	-0.9	-1.7	-1.0	-1.6
Average weekly fortified wine intake	1.9	2.2	8.7	-2.9	-0.3	-0.7	-1.3	-1.0	-2.1	-1.2	-1.4	-1.6	-0.8	-0.9	-1.4	-1.9
Medication: Atenolol	1.9	2.4	6.5	0.7	0.7	1.4	2.3	1.4	1.6	2.5	1.4	1.3	-0.1	1.7	1.9	1.2
Heart attack	1.9	2.5	4.6	0.4	1.0	1.5	1.9	1.6	1.9	1.5	1.4	2.1	1.0	1.7	1.9	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	5.1	1.0	2.3	0.6	1.6	2.0	1.4	0.4	0.7	2.0	2.2	1.1	1.4	1.5
Commuting to job workplace: Walk	1.9	2.0	4.4	-1.8	-0.4	-1.8	-2.0	-0.9	-1.0	-2.0	-2.1	-1.5	-1.0	-0.9	-0.8	-0.5
Lupus	1.8	2.8	5.7	1.6	1.3	1.5	1.7	1.8	1.7	1.9	2.4	1.9	-0.7	1.4	1.7	1.6
Serious illness, injury or assault to yourself	1.8	2.1	5.0	1.3	1.3	0.9	1.2	1.0	2.2	1.8	1.8	1.8	0.8	0.9	1.4	1.8
Waist circumference	1.8	6.5	10.4	2.7	2.4	1.6	2.9	2.5	3.1	3.2	3.1	2.6	1.1	2.1	2.3	2.6
Hip circumference	1.8	7.9	12.6	3.4	2.6	1.5	3.0	2.8	3.5	3.0	2.9	3.0	1.8	2.3	2.8	3.1
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	5.2	-1.8	-1.0	-2.3	-2.0	-1.1	-1.5	-2.2	-1.8	-1.7	-0.8	-1.9	-2.1	-1.4
Mood swings	1.8	3.3	6.8	1.4	1.5	2.5	2.3	2.1	1.6	2.6	1.5	1.5	0.8	2.0	1.5	1.4
Qualifications: nursing, teaching	1.8	2.8	7.6	-2.0	-1.3	-2.7	-2.2	-1.5	-1.1	-2.8	-1.9	-1.1	-0.1	-1.4	-0.8	-0.6
Hayfever, allergic rhinitis or eczema	1.7	3.7	11.1	-1.7	-1.4	-3.3	-2.7	-2.0	-0.8	-2.9	-1.6	-1.2	-0.5	-2.6	-1.2	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	7.4	-1.3	-0.3	-0.4	-1.3	-0.9	-2.3	-0.4	-0.7	-1.6	-0.8	-1.7	-2.1	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.2	2.0	0.4	0.7	1.9	1.6	1.6	1.7	1.5	1.6	0.8	0.9	1.1	1.2
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	8.5	0.7	-0.3	-1.0	-0.2	-0.1	1.4	-2.0	-0.3	1.4	1.2	1.5	1.5	2.9
Allergy	1.6	3.6	8.8	0.7	1.8	3.0	2.4	2.4	1.0	2.6	1.4	1.5	1.1	2.2	1.8	0.8
Tense / ‘highly strung’	1.6	2.6	5.9	-1.1	-1.4	-1.0	-1.6	-1.6	-0.9	0.3	-1.6	-2.0	-2.4	-2.2	-2.0	-1.6
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	4.5	1.8	1.4	-0.4	0.9	0.5	1.8	-0.7	1.1	1.7	2.0	0.8	1.6	2.1
Hair/balding pattern: Pattern 2	1.5	2.0	4.7	1.8	2.0	0.8	1.5	1.0	2.2	1.0	0.2	1.1	0.2	1.2	1.4	2.0
Medication: Paracetamol	1.5	2.6	6.8	0.9	1.8	-0.9	1.6	1.5	2.2	-0.5	1.3	2.2	1.6	1.0	1.3	2.6
Qualifications: College or University degree	1.5	4.9	12.9	-3.6	-1.8	-1.6	-2.4	-1.8	-3.1	-2.7	-1.6	-1.7	0.4	-1.6	-1.6	-2.8
Average weekly red wine intake	1.5	2.3	5.3	-2.3	-2.1	-1.0	-1.9	-1.5	-1.3	-2.1	-1.5	-1.4	0.1	-1.2	-0.6	-1.1
Diabetes diagnosed by doctor	1.5	2.5	5.1	1.1	0.6	-0.2	1.5	1.8	1.7	-0.3	1.6	2.0	2.2	1.6	1.8	2.3
Coronary Artery Disease (CAD)	1.4	1.7	7.7	2.8	1.0	1.1	1.1	1.4	0.8	1.7	0.9	1.2	-0.2	1.0	1.2	0.7
Blood White Count	1.4	10.2	17.2	3.7	2.9	2.9	3.9	3.3	3.4	4.2	2.7	3.0	1.2	3.3	3.2	2.9
Lung FVC	1.4	7.1	15.6	-1.9	-1.6	-1.5	-2.9	-3.2	-3.6	-1.2	-1.8	-3.2	-1.6	-2.9	-3.3	-4.0
Systolic blood pressure, automated reading	1.4	4.2	7.3	1.0	2.7	1.9	2.2	2.5	1.6	1.3	2.4	2.5	2.3	2.2	1.3	1.9
Hearing difficulty/problems with background noise	1.4	2.2	5.3	-1.0	-0.6	-2.3	-2.1	-1.5	0.0	-1.3	-2.0	-1.5	-1.2	-2.3	-1.0	-0.6
Lung FEV1/FVC ratio	1.3	6.7	13.2	2.5	0.6	3.6	3.4	3.0	1.5	3.6	2.5	2.4	1.2	3.4	2.0	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.6	1.7	1.6	0.1	1.2	1.1	1.9	1.0	1.0	1.6	1.4	0.7	0.8	1.8
Had other major operations	1.3	1.6	3.9	2.0	0.1	0.2	1.1	0.1	1.7	-0.0	1.1	1.5	0.8	1.1	1.8	2.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	7.0	0.8	0.9	-0.5	1.2	0.6	2.6	0.9	1.4	1.7	0.8	1.0	1.6	2.5
Qualifications: A levels/AS levels or equivalent	1.3	2.8	8.4	-2.1	-1.6	-1.8	-2.5	-0.9	-1.7	-2.9	-1.6	-1.0	0.6	-1.3	-0.7	-1.3
Whole body fat mass	1.3	5.5	9.4	2.8	3.1	1.4	2.6	2.0	2.8	3.0	2.6	2.1	0.6	1.7	2.1	2.3
Leg pain on walking	1.3	1.6	3.0	1.2	1.4	-0.1	1.7	1.0	1.7	1.2	1.0	1.4	1.1	1.0	1.1	1.6
Financial situation satisfaction	1.3	1.6	3.9	0.5	-1.5	-0.7	-0.9	-1.1	-1.2	-0.1	-1.7	-2.0	-1.2	-1.2	-1.5	-1.6
Crohns Disease (2017)	1.2	2.6	5.8	1.8	1.4	1.5	1.8	1.3	1.2	1.9	2.4	1.7	-0.6	1.4	1.7	1.1
Reaction Time	1.2	2.2	6.6	0.1	0.2	-0.8	-1.6	-1.1	-1.7	0.2	-0.5	-1.6	-2.3	-1.9	-1.6	-2.6
Asthma	1.2	2.4	4.1	0.4	-0.7	-1.6	-1.8	-1.7	-1.5	-1.0	-1.2	-1.6	-1.6	-2.0	-1.9	-1.9
Supplements: Vitamin C	1.2	1.4	5.9	1.7	-0.5	-0.5	0.6	0.8	2.4	0.4	-0.6	0.7	0.1	0.4	1.7	2.1
Verbal and Numeric Reasoning (VNR)	1.1	2.6	9.4	-2.4	-1.1	-0.0	-1.1	-0.5	-3.1	-1.5	-0.5	-1.7	0.6	-1.0	-1.6	-2.7
Triglycerides	1.1	1.8	3.8	1.9	-0.0	0.9	0.8	1.6	1.1	0.5	1.3	1.6	1.6	1.7	1.6	1.5
Number of treatments/medications taken	1.1	1.9	5.2	0.4	1.1	-0.4	1.3	0.6	2.3	0.2	1.4	2.1	1.2	0.9	1.7	2.3
Medication: Metformin	1.1	1.6	6.2	0.5	-0.1	-0.3	1.2	1.2	1.3	-0.2	1.5	1.3	2.5	1.1	1.2	1.8
Falls in the last year	1.1	1.4	3.9	1.2	1.4	-0.8	0.9	0.1	1.7	-0.1	1.4	1.4	0.9	0.8	1.3	2.0
Emphysema/chronic bronchitis	1.1	1.3	2.6	-0.8	-1.6	-0.1	-0.9	-1.4	-0.9	-1.3	-1.5	-1.6	-1.1	-0.6	-1.4	-0.1
Pulse rate, automated reading	1.1	3.5	12.0	2.2	2.0	1.2	2.4	1.7	1.1	1.8	3.5	1.6	1.3	1.5	1.1	1.2
Arm fat percentage (left)	1.1	4.3	8.5	2.6	2.7	0.7	2.2	1.4	2.9	2.3	2.0	2.0	0.5	1.4	2.1	2.5
Asthma (self-reported)	1.1	2.1	3.6	0.5	-0.6	-1.7	-1.9	-1.7	-1.2	-1.3	-1.5	-1.5	-1.3	-1.9	-1.6	-1.5
Ever taken oral contraceptive pill	1.1	1.3	3.8	-0.5	-1.9	-0.0	-1.3	-1.2	-0.2	0.3	-1.0	-1.1	-1.9	-1.5	-0.8	-0.8
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.9	0.8	-1.1	0.1	1.7	1.0	0.8	0.3	1.1	1.6	2.2	0.7	0.8	0.7
Neuroticism (Nagel 2018)	1.0	2.2	5.8	-1.2	-0.3	-0.7	-1.8	-1.4	-1.6	-1.0	-2.4	-2.1	-1.1	-1.4	-1.7	-1.4
Breast Cancer	1.0	2.4	4.3	-0.6	-1.2	-1.9	-1.6	-1.6	-1.8	-1.4	-1.8	-2.1	-0.5	-1.6	-1.6	-1.6
Allergy or Eczema	1.0	2.7	6.4	-1.8	-1.8	-2.5	-2.2	-1.8	-0.2	-2.1	-1.6	-1.0	-0.3	-2.2	-1.0	-0.3
Arm fat percentage (right)	1.0	3.8	7.9	2.6	2.8	0.4	2.0	1.3	2.8	1.9	1.7	1.9	0.4	1.2	1.9	2.5
Medication: Cholesterol lowering	1.0	1.6	3.7	1.4	0.8	1.9	1.6	0.9	0.6	1.1	1.2	1.4	0.9	1.6	1.3	0.8
Breastfed as a baby	1.0	1.2	4.9	0.1	0.8	1.2	1.0	0.8	-0.8	-0.4	1.0	1.0	2.2	2.1	0.4	0.4
Commuting to job workplace: Public transport	1.0	1.2	4.5	-0.3	-0.8	1.0	-0.0	-0.7	-2.1	0.6	0.1	-1.1	-1.8	-0.2	-0.4	-2.0
Pack years of smoking	1.0	1.5	4.1	0.9	0.0	0.7	0.5	0.2	1.6	-0.2	-0.3	1.5	2.0	1.7	1.6	2.0
Fasting Glucose	0.9	1.0	2.4	-1.5	-1.4	-0.6	-1.3	-0.9	-0.4	-0.8	-1.2	-1.4	-0.8	-0.8	-0.8	-0.3
Pack years adult smoking proportion	0.9	1.4	4.4	1.1	0.0	0.0	0.1	-0.1	2.0	0.0	-0.8	1.2	1.4	1.1	1.6	2.1
Townsend deprivation index at recruitment	0.9	1.3	3.4	1.9	-0.1	0.6	1.6	0.7	1.5	0.8	1.2	1.1	0.6	0.7	1.0	1.6
Multivitamins +/- minerals	0.9	1.2	2.9	0.8	-0.6	1.1	1.1	1.3	1.2	0.0	0.4	1.3	1.7	1.0	1.3	1.2
Trunk fat mass	0.9	3.9	7.1	2.5	2.7	1.1	2.0	1.5	2.4	2.5	2.4	1.7	0.3	1.3	1.8	2.0
Illnesses of siblings	0.9	1.2	5.6	-0.9	-2.4	-1.7	-0.4	-0.5	-0.9	-1.5	-0.6	-0.5	1.0	-0.9	-0.4	-0.7
Neuroticism score	0.9	1.8	5.0	-0.4	-1.0	-0.8	-1.4	-1.1	-0.8	0.2	-1.9	-1.8	-2.2	-1.5	-1.2	-1.3
Alcohol intake versus 10 years previously	0.9	1.4	4.2	1.6	0.7	1.5	2.1	1.3	0.5	1.5	1.2	1.1	0.5	1.0	0.4	0.6
Hair/balding pattern: Pattern 4	0.9	2.1	6.6	-2.5	-0.6	-0.3	-1.1	-1.2	-2.6	-1.6	-0.5	-1.3	0.0	-0.7	-1.4	-2.0
Loud music exposure frequency	0.9	1.0	2.8	-1.0	1.3	-0.7	-1.0	-0.1	-0.3	-0.2	-1.7	-1.1	-1.1	-1.2	-1.0	-0.6
Birth weight	0.9	2.0	4.7	1.3	2.2	0.8	1.2	1.3	1.5	1.4	1.8	1.4	0.3	1.2	1.7	1.1
Exposure to tobacco smoke outside home	0.9	1.2	4.0	1.8	1.4	-0.1	0.8	0.3	2.0	0.4	-0.2	0.8	0.0	0.5	1.1	2.0
Medication: Aspirin	0.9	1.1	2.3	0.7	1.5	0.8	0.6	1.3	0.8	-0.1	0.4	1.5	0.4	1.5	1.3	1.4
Guilty feelings	0.9	1.3	3.3	-1.0	0.0	-1.0	-1.1	-0.5	-0.4	-0.9	-1.7	-1.2	-1.8	-1.6	-1.3	-0.6
Eye problems/disorders: Glaucoma	0.9	1.0	2.2	-0.6	-1.3	-1.1	-0.6	-1.3	-0.5	0.7	0.2	-1.0	-1.5	-1.3	-0.9	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	4.8	1.0	2.2	-0.5	1.1	-0.1	1.2	0.3	1.0	1.0	1.1	0.5	0.8	1.2
Bipolar Disorder (2018)	0.8	1.3	4.2	-0.0	0.3	-1.6	-1.7	-1.7	-0.4	-0.6	-2.0	-0.8	-1.1	-1.2	-0.6	-0.5
Alzheimer’s Disease (in father)	0.8	0.8	2.5	1.0	-0.2	1.2	0.8	1.6	-0.2	-0.2	1.0	1.1	1.4	0.9	0.2	0.2
Irritable Bowel Disease (IBD)	0.8	2.0	4.3	1.6	1.4	2.0	1.4	1.5	0.4	2.1	1.7	1.1	-0.5	1.4	1.3	0.4
Respiratory disease	0.8	1.9	3.8	-0.1	-0.8	-2.0	-1.6	-1.8	-0.5	-1.4	-1.6	-1.5	-1.2	-1.9	-1.5	-0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.1	3.8	-0.3	0.0	-0.4	0.0	-0.5	1.2	-1.1	-0.2	0.9	1.7	1.2	1.3	2.0
Hand grip strength (right)	0.8	2.2	4.6	2.0	1.1	1.4	1.8	1.5	1.5	2.1	2.1	1.5	0.1	0.8	1.3	0.7
Age when periods started (menarche)	0.8	1.9	3.3	-1.4	-1.1	-0.7	-1.6	-1.3	-1.6	-1.0	-1.1	-1.8	-1.0	-1.5	-1.4	-1.6
Number of incorrect matches in round	0.8	1.3	2.7	-1.1	-1.1	-1.4	-1.5	-1.7	-0.3	-1.0	-1.4	-1.4	-0.6	-1.1	-0.5	-0.4
Past tobacco smoking	0.8	1.4	5.7	1.1	-2.4	-0.1	1.3	0.6	1.5	1.8	0.2	1.1	-0.8	0.3	1.1	0.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.0	-0.9	-0.9	-0.9	-1.7	-1.0	-0.9	-1.5	-1.1	-0.8	-0.4	-1.0	-0.5	-0.6
Worrier / anxious feelings	0.8	1.6	4.4	-1.3	-0.9	-1.4	-1.9	-1.1	-0.3	-0.6	-2.1	-1.5	-0.9	-1.4	-0.8	-0.9
Birth weight of first child	0.8	1.5	4.4	0.4	0.1	-1.3	0.9	0.2	1.3	-1.2	0.7	1.7	2.1	0.8	1.3	2.0
Glaucoma (self-reported)	0.8	0.9	2.8	-0.6	-1.7	-1.6	-0.7	-1.5	0.1	-0.1	0.1	-0.9	-0.8	-1.4	-0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	7.2	-0.5	-0.3	-2.7	-1.2	-0.8	0.0	-2.5	-0.5	-0.4	0.8	-1.5	-0.5	0.2
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.6	1.3	-0.1	1.9	1.5	0.8	0.5	1.1	1.2	0.4	0.3	1.1	0.3	0.5
Heart disease (mother)	0.8	0.9	5.2	2.3	0.0	-0.1	0.9	0.4	1.4	0.3	0.2	1.0	0.1	0.4	0.9	1.2
Osteoporosis (self-reported)	0.8	1.0	2.1	-1.2	-0.1	0.0	-1.1	-0.7	-1.2	-0.5	-0.9	-1.2	-0.9	-1.1	-1.5	-1.1
Wears glasses or contact lenses	0.8	0.9	2.5	-1.3	-1.0	-0.4	-1.0	-1.0	-1.0	-1.6	-1.2	-0.8	0.7	-0.0	-0.7	-0.3
Alcohol drinker status: Never	0.8	1.0	2.9	1.2	0.5	-0.3	0.6	0.4	1.7	0.4	1.4	1.0	0.6	0.3	1.5	1.3
Supplements: Calcium	0.8	0.9	2.4	-1.5	-0.7	0.0	-1.3	-1.0	-0.7	-0.8	-0.9	-0.9	-0.9	-0.9	-0.9	-0.9
Alcohol drinker status: Previous	0.8	0.9	3.5	-1.9	1.6	-1.1	-1.1	-0.8	-0.1	-0.8	-0.9	-0.4	-0.0	-0.6	-0.5	0.1
Major Depression (MDD)	0.7	0.8	2.0	-1.4	0.1	-1.4	-1.1	-0.6	-0.3	-1.4	-1.0	-0.7	0.2	-1.1	-0.5	-0.2
Ovarian Cancer	0.7	0.9	4.2	1.0	2.1	0.7	1.2	0.7	0.0	-0.2	0.6	0.8	1.2	1.2	0.6	0.6
Mean Putamen Volume	0.7	0.8	3.1	-0.6	-1.1	1.8	0.8	0.2	-1.6	-0.1	0.5	-0.2	0.6	0.5	-0.5	-1.2
LDL Cholesterol	0.7	1.1	2.5	1.6	0.3	1.4	0.6	0.9	0.6	0.9	1.4	1.3	0.9	1.4	1.0	0.7
Ulcerative Colitis	0.7	1.0	5.1	0.6	-0.5	1.9	0.6	1.2	-0.2	2.3	0.8	0.1	-0.5	0.6	0.4	-0.6
Relative age of first facial hair	0.7	1.5	2.9	-1.7	-0.6	-0.7	-1.7	-1.7	-1.1	-0.6	-1.0	-1.3	-1.4	-0.9	-0.9	-1.2
Severe depression (siblings)	0.7	0.8	1.9	1.3	1.1	0.4	0.7	1.4	1.2	0.3	0.3	0.5	1.4	0.5	0.6	1.0
Alcohol usually taken with meals	0.7	1.1	3.2	-0.4	1.2	-0.1	0.7	1.2	0.8	0.2	0.8	1.1	1.8	1.3	1.5	0.9
Had menopause	0.7	0.9	2.3	-1.5	0.7	-0.9	-0.9	-0.4	-1.3	-1.1	-0.3	-0.9	-0.2	-0.7	-1.2	-1.1
Forced vital capacity (FVC)	0.7	2.6	8.9	-1.0	-1.1	0.2	-1.4	-1.1	-2.3	0.8	-0.3	-2.0	-1.6	-1.6	-1.9	-3.0
Qualifications: None of the above	0.7	1.5	4.2	2.0	2.0	0.0	1.2	0.9	1.6	0.4	1.2	1.2	0.2	0.7	0.8	1.6
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	4.7	-2.2	-1.3	0.3	-0.8	-0.0	-1.4	-1.1	-1.1	-0.5	1.4	-0.5	-0.6	-1.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.5	-1.0	-1.9	-1.2	-0.3	-0.6	-0.8	-1.5	-0.0	-0.0	0.8	-0.4	-0.7	-0.4
Wheeze or whistling in the chest in last year	0.7	1.3	4.6	1.0	1.4	-2.1	-0.1	-0.3	1.8	-1.1	-0.0	0.7	0.4	-0.8	0.6	1.6
Medication: Seretide 50 evohaler	0.7	0.8	2.3	0.9	-0.4	1.2	0.8	1.5	-0.7	0.2	0.7	0.6	1.2	1.2	0.9	-0.3
Family relationship satisfaction	0.7	0.8	2.8	0.9	0.3	0.4	0.6	0.8	1.7	1.0	-0.5	0.5	-0.2	0.8	1.2	1.4
Medication: Bendroflumethiazide	0.7	1.0	4.5	-0.3	2.1	-1.5	-0.1	0.3	1.5	-0.1	0.1	0.5	-0.2	0.3	1.0	1.6
Ever smoked	0.7	1.2	5.3	-1.2	2.3	0.2	-1.2	-0.6	-0.9	-1.7	-0.6	-1.0	0.8	-0.2	-0.7	-0.3
Depression (Nagel 2018)	0.6	0.8	1.7	0.9	1.1	0.1	0.7	0.9	1.3	0.7	0.9	1.2	1.2	0.4	0.6	1.0
HDL Cholesterol	0.6	1.1	2.7	-1.6	0.4	-1.4	-1.3	-1.4	-0.0	-0.6	-0.9	-1.0	-0.4	-1.4	-0.8	-0.5
Waist Hip Ratio (WHR)	0.6	2.6	4.8	-2.1	-1.5	-0.5	-1.3	-1.5	-2.1	-0.5	-1.0	-2.2	-2.0	-1.1	-1.8	-1.9
Neuroticism	0.6	1.5	3.6	-1.0	-0.0	-0.8	-1.5	-1.1	-0.7	-0.4	-1.8	-1.9	-1.3	-1.4	-1.3	-0.9
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.7	0.9	0.2	0.1	0.8	1.0	1.3	1.0	0.7	1.1	1.3	0.6	0.8	1.0
Hearing difficulty/problems: Yes	0.6	0.9	1.9	0.8	0.5	-0.3	0.6	0.6	1.0	-1.3	0.6	1.4	1.3	0.7	1.1	1.4
Medication: Co-codamol	0.6	0.7	2.4	0.5	1.5	0.5	0.9	0.4	1.3	1.1	-0.1	0.7	-0.2	0.7	0.4	1.3
Diabetes (mother)	0.6	0.7	3.0	-0.5	-1.0	0.8	0.2	0.9	-1.2	-0.2	0.1	-0.3	0.6	-0.7	-1.7	-1.2
Relative age voice broke	0.6	1.0	2.6	-1.0	-1.6	-0.3	-1.2	-1.2	-1.2	-0.4	-1.2	-0.8	-0.1	-0.5	-0.7	-1.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.7	-0.6	-0.4	1.0	-0.3	-0.9	-1.3	-1.0	-1.2	-0.5	1.1	0.7	-0.8	-0.5
Number of live births	0.6	0.8	2.5	0.3	-0.2	-1.6	-0.3	-1.0	0.7	-1.5	-1.2	-0.5	0.9	-0.2	0.1	1.2
Happiness	0.6	0.7	2.7	1.5	-1.3	-0.0	0.1	0.4	0.8	1.6	-1.1	-0.4	-0.8	-0.0	0.6	0.0
Noisy workplace	0.6	0.7	2.4	1.5	0.8	-1.2	0.3	-0.5	1.3	-0.8	0.3	0.7	0.8	-0.1	0.2	1.2
Blood clot in the leg (DVT)	0.6	0.7	1.8	0.7	0.1	0.4	0.8	0.2	1.2	0.6	1.0	1.0	0.7	1.1	0.8	1.4
Forced vital capacity (FVC), Best measure	0.6	2.3	7.8	-1.1	-0.4	-0.1	-1.5	-1.2	-2.5	0.1	-0.4	-2.0	-1.4	-1.3	-1.6	-2.8
Body fat percentage	0.6	2.2	7.2	1.9	2.7	0.4	1.5	0.9	1.8	1.8	1.7	1.2	0.1	0.8	1.1	1.5
Mean time to correctly identify matches	0.6	1.1	4.8	-0.2	0.7	-0.4	-1.0	-0.3	-1.6	0.1	0.3	-0.9	-1.3	-1.2	-1.2	-2.2
Illnesses of father: Heart disease	0.6	0.8	1.8	0.9	1.0	0.9	1.1	0.8	0.6	0.5	1.3	1.1	0.2	1.1	0.6	0.8
Illnesses of siblings: Diabetes	0.6	0.7	2.3	0.2	-0.2	1.5	0.7	1.2	-0.2	1.3	1.5	0.2	-0.9	0.5	-0.3	-0.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.9	0.2	-0.7	-1.7	-0.5	-1.3	0.7	-1.1	-1.0	0.0	-0.4	-0.5	0.2	0.8
Fractured/broken bones in last 5 years	0.6	0.8	2.8	-1.1	1.0	-0.7	-1.1	-1.2	0.1	-1.7	-0.7	-0.3	-0.3	-0.0	-0.0	0.9
Unable to work because of sickness or disability	0.6	0.8	3.6	1.1	1.9	-0.5	1.0	0.7	0.8	0.5	0.9	0.8	0.5	0.3	0.7	0.6
Heart disease (siblings)	0.6	0.7	4.1	0.5	2.0	0.1	-0.0	-0.4	1.3	0.1	0.3	0.6	-0.5	0.2	0.9	1.1
Depressed Affect (Nagel 2018)	0.5	1.0	2.3	0.9	1.2	1.1	1.2	1.0	0.3	0.6	0.5	0.8	1.4	1.5	0.7	0.7
Alzheimer’s Disease (in mother)	0.5	0.6	2.1	-1.0	0.5	-1.4	-0.1	-0.2	0.3	-1.4	-0.5	0.2	1.1	-0.2	0.2	0.7
Alzheimer’s Disease (including proxy)	0.5	0.7	4.9	-0.2	0.2	-0.1	0.8	0.7	0.1	-0.7	-0.0	1.1	2.2	0.9	0.4	0.7
Bipolar Disorder (2011)	0.5	0.5	2.4	-1.5	0.3	-0.5	-0.8	-0.3	0.5	0.4	-1.2	-0.2	-0.5	0.1	0.6	0.3
HbA1C	0.5	0.6	3.2	-0.3	-1.5	-1.8	0.1	-0.5	0.4	-0.8	-0.3	-0.4	0.3	-0.5	-0.1	0.4
Systolic Blood Pressure	0.5	2.3	8.1	0.8	1.1	2.9	1.6	1.6	1.2	2.6	1.4	1.4	0.2	1.3	0.8	0.7
Hypothyroidism (self reported)	0.5	1.2	6.2	-0.6	0.2	-2.5	-1.2	-0.8	0.2	-1.9	-0.7	-0.5	1.1	-1.2	-0.4	0.3
Average weekly spirits intake	0.5	0.6	1.7	-0.6	-1.3	-0.3	-0.2	-0.3	-0.8	-0.2	-0.9	-0.6	-0.4	-1.2	-0.9	-1.2
Maternal smoking around birth	0.5	0.7	2.1	0.2	-1.5	-0.9	-0.7	-0.8	-0.6	-0.6	-1.2	-0.6	-1.0	-0.8	-1.0	-0.5
Qualifications: CSEs or equivalent	0.5	0.6	3.3	1.8	0.5	0.6	0.8	0.3	0.9	1.2	0.3	0.8	-0.3	0.3	0.4	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.6	-1.1	-1.6	-0.1	-0.6	-0.4	-1.5	-0.6	-1.0	-0.6	-0.6	-1.1	-1.4	-1.6
Pain all over the body in last month	0.5	0.5	2.7	0.2	1.1	-0.4	-0.1	0.4	0.5	-0.5	1.6	0.7	1.0	-0.1	0.4	0.4
Fluid intelligence score	0.5	1.1	4.2	-1.9	-0.9	0.0	-0.5	0.1	-2.1	-0.7	0.1	-0.8	0.6	-0.5	-0.6	-1.9
Hair/balding pattern: Pattern 3	0.5	0.8	4.5	-1.1	-2.1	0.2	-0.4	-0.5	-1.1	0.0	0.3	-0.8	0.2	-0.5	-0.9	-1.2
Depression (self-reported)	0.5	0.6	1.4	-0.7	-0.3	-1.0	-0.9	-0.4	-0.4	-0.7	-0.7	-1.2	-0.9	-1.0	-0.8	-0.3
Prospective memory result	0.5	0.7	2.0	1.0	-0.5	1.2	0.4	0.3	1.0	0.6	0.0	0.2	-0.2	1.3	0.7	1.4
Illnesses of mother	0.5	0.6	2.0	-0.4	-0.2	0.9	-0.8	-0.6	-1.4	-0.2	-0.5	-0.7	-1.2	-0.3	-0.7	-1.2
Length of working week for main job	0.5	0.6	2.9	1.7	-0.7	0.3	0.9	1.1	-0.6	0.4	0.7	0.4	0.2	-0.1	0.0	-0.8
Eye problems/disorders: None of the above	0.5	0.6	2.9	-0.6	-0.7	-0.3	-0.9	-0.5	-0.6	-1.1	-1.7	-0.8	-0.5	0.1	-0.4	0.2
Had major operations	0.5	0.6	1.8	0.5	0.8	0.0	1.3	1.1	0.4	0.4	1.2	0.9	0.5	0.5	0.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	1.2	1.0	0.9	0.7	-0.2	1.2	0.6	0.4	0.7	-0.1	0.6	0.5	1.1
Smoking status: Previous	0.5	0.7	3.7	-0.6	1.9	0.6	-0.8	0.0	-1.3	-0.8	0.3	-0.9	0.4	0.1	-0.7	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.2	-1.0	-1.8	-0.6	-0.8	-0.7	-0.7	-0.6	-0.7	-0.7	0.0	0.0	-0.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.4	-0.4	0.6	-1.3	-0.8	-0.4	0.4	-1.5	-1.0	0.1	1.4	-0.1	0.5	0.9
Mineral and other dietary supplements	0.5	0.6	2.3	0.8	0.6	0.7	0.6	1.5	0.0	0.5	0.5	0.7	1.3	0.8	0.7	0.2
Medication: Aspirin	0.5	0.7	1.9	0.3	1.4	0.6	0.3	0.8	0.4	-0.7	0.2	1.2	0.1	1.1	0.9	1.2
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.9	-0.8	-0.1	-1.2	-0.6	-1.4	-0.2	-1.3	-0.5	-0.8	-0.6	-0.8	-0.8	-0.0
High cholesterol (Self-reported)	0.5	1.0	2.9	1.7	0.7	0.8	1.2	0.9	0.9	1.5	1.1	0.7	-0.0	0.8	0.6	0.7
Irritability	0.5	0.8	2.4	1.6	0.3	1.1	1.0	0.4	0.5	1.4	1.3	0.6	-0.3	0.9	0.7	0.4
Basal cell carcinoma (self-reported)	0.5	0.6	2.9	0.8	0.3	-0.5	0.1	0.3	-0.3	-1.4	1.0	0.5	1.7	0.4	-0.1	0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.5	0.5	-0.1	0.5	0.8	0.2	1.2	0.8	0.8	0.9	0.6	1.0	0.7	1.2
Bipolar Disorder or Schizophrenia	0.4	0.9	3.1	0.4	-0.2	-0.2	-1.4	-0.6	-0.7	0.1	-1.3	-1.1	-1.8	-0.9	-0.5	-1.1
Schizophrenia vs Biploar Disorder	0.4	0.6	3.3	1.8	0.1	-0.4	0.7	0.7	0.2	0.1	1.3	0.2	-1.0	-0.5	-0.1	-0.1
Ulcerative Colitis (UC)	0.4	0.8	2.7	0.7	0.8	1.6	0.4	1.4	-0.2	1.6	0.9	0.4	0.0	0.9	0.8	-0.2
Age at First Birth	0.4	0.5	2.0	0.4	0.3	0.1	-0.9	0.8	-1.4	0.1	-0.6	-0.7	-0.7	-0.2	-0.5	-1.1
Ever had hysterectomy (womb removed)	0.4	0.5	1.4	0.8	0.3	-1.1	-0.8	-0.9	0.3	-0.8	-1.2	-0.3	0.1	0.1	0.1	0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.5	0.6	1.2	0.6	0.1	0.5	-0.1	0.7	0.9	-0.2	-1.2	0.0	-0.1	-0.3
Diabetes (father)	0.4	0.6	1.9	-0.1	0.6	-0.5	1.2	0.4	0.5	0.1	1.4	1.2	0.9	0.3	0.7	0.4
Father’s age at death	0.4	0.5	1.8	-1.0	-0.1	-0.9	-0.3	0.1	-1.0	-1.3	-0.4	-0.2	0.8	-0.2	-0.7	-0.4
Mouth/teeth dental problems: Dentures	0.4	0.6	1.6	0.2	0.3	1.0	0.9	0.6	0.8	-0.1	0.3	0.9	0.9	1.1	0.9	1.3
Pulse wave Arterial Stiffness index	0.4	0.4	0.9	-0.7	-0.9	-1.0	-0.8	0.2	-0.4	-0.9	-0.0	-0.1	0.2	-0.8	-0.7	-0.5
Exposure to tobacco smoke at home	0.4	0.4	2.8	-0.2	1.7	0.1	0.1	-0.0	0.5	0.7	0.6	-0.2	-1.2	-0.2	-0.3	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.1	-0.9	0.1	-1.8	-0.5	-0.6	0.4	-0.9	-0.3	-0.2	0.7	-1.0	0.0	0.2
Pulse wave reflection index	0.4	0.6	2.4	-0.7	-1.0	-1.2	-0.4	0.3	0.1	-1.5	-0.4	0.4	1.1	0.0	-0.0	0.4
Number of children fathered	0.4	0.5	1.9	0.2	1.1	-0.6	-0.6	-0.6	1.4	0.1	-0.4	-0.1	-0.6	-0.2	0.6	1.0
Health satisfaction	0.4	0.6	2.0	1.3	0.2	-1.4	0.1	-0.8	1.3	0.2	0.1	-0.2	-0.3	-0.5	-0.2	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.1	0.6	1.0	-0.6	0.7	-0.9	-0.4	-0.8	0.7	-0.3	-0.3	-0.6	-1.0	-0.2
Breast cancer (self-reported)	0.4	0.4	0.9	-0.6	-0.0	0.3	-0.9	-0.8	-0.6	0.2	-0.2	-0.9	-0.4	-0.7	-0.9	-0.9
Medication: Gliclazide	0.4	0.4	1.7	0.1	0.9	-0.7	0.3	0.3	1.1	-0.2	0.3	0.8	0.1	0.3	0.5	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.7	-0.4	0.9	1.0	0.9	0.8	-0.8	1.1	1.7	0.6	1.0	0.8	0.3	-1.0
Mother’s age at death	0.4	0.5	1.8	-0.6	1.0	-0.5	0.0	-0.3	0.8	-0.7	-0.1	0.7	1.3	0.3	0.8	0.8
Medication: Atorvastatin	0.4	0.5	1.1	0.7	0.5	0.7	0.2	1.0	0.8	0.6	-0.6	0.6	0.5	0.8	1.1	0.5
Average weekly beer plus cider intake	0.4	0.5	6.3	0.4	2.5	0.0	0.2	-0.0	0.5	0.2	0.1	-0.0	0.3	-0.1	-0.2	0.4
Commuting to job workplace: Cycle	0.4	0.5	2.8	-0.8	0.8	-1.4	-0.3	-0.6	-0.6	-1.7	-0.2	-0.2	0.2	-0.1	0.3	-0.1
Neuroticism (2016)	0.3	0.5	1.4	-0.6	0.5	-0.8	-0.8	-0.3	0.1	0.4	-0.7	-0.6	-1.2	-0.8	-0.9	-0.4
Schizophrenia (2014)	0.3	0.7	2.5	0.9	0.8	0.5	-0.7	0.4	-0.5	0.8	0.1	-0.9	-1.6	-0.9	-0.7	-1.3
Blood Red Count	0.3	2.8	7.5	2.3	1.0	1.9	2.3	2.7	-0.3	1.4	2.2	1.3	1.6	1.6	0.2	-0.0
Smoking Status	0.3	0.7	4.4	0.4	0.6	-0.3	0.2	-0.1	-0.5	-2.1	-0.0	0.3	1.9	0.6	-0.3	0.5
Hand grip strength (left)	0.3	0.8	2.0	1.4	1.0	-0.1	0.6	0.5	1.4	0.9	0.9	0.7	-0.5	0.2	1.0	1.0
Trunk fat percentage	0.3	1.3	6.5	1.4	2.5	0.0	0.8	0.4	1.5	1.3	1.2	0.6	-0.4	0.3	0.8	1.1
Fed-up feelings	0.3	0.5	2.4	1.4	-0.8	0.2	0.9	0.2	0.4	1.6	0.3	0.2	-0.4	0.3	0.5	-0.0
Taking other prescription medications	0.3	0.5	1.5	0.1	1.2	-0.4	0.4	-0.3	0.9	-0.6	0.4	0.9	0.8	0.0	0.8	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.6	-0.6	-0.3	-0.4	-0.1	-0.4	0.9	-0.5	-0.0	0.4	0.1	0.4	0.3	1.3
Stomach or abdominal pain in last month	0.3	0.3	1.1	0.4	0.4	-0.6	-0.4	-0.7	0.0	-0.2	-0.6	-0.5	-1.0	-0.6	-0.8	-0.1
Medication: Levothyroxine sodium	0.3	0.6	2.5	-0.8	0.5	-1.6	-0.9	-0.1	0.0	-1.2	-0.1	-0.6	-0.5	-1.1	-0.2	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.7	0.1	-1.0	-1.3	-0.3	-0.7	1.1	-0.3	-0.5	0.1	-0.1	-0.8	-0.3	0.9
Mouth/teeth dental problems	0.3	0.5	3.0	0.5	0.4	0.6	0.6	0.4	0.2	1.7	0.7	0.2	-1.2	0.1	0.1	-0.4
Medication: Ramipril	0.3	0.3	1.0	0.6	0.5	-0.2	-0.7	-1.0	0.2	-0.5	-0.5	-0.7	-1.0	0.2	0.1	0.5
Time employed in main current job	0.3	0.4	1.6	-0.3	-0.6	0.8	0.5	1.3	0.1	0.4	0.4	0.4	1.0	0.5	0.3	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.0	0.3	-1.0	1.5	-0.0	-0.1	-1.1	2.0	0.6	-0.7	-1.0	-0.1	-0.6	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.7	-0.3	-0.1	1.2	-0.2	-0.3	-1.7	1.3	0.6	-0.9	-0.8	0.0	-0.6	-1.9
Standing height	0.3	3.0	8.1	-1.5	-2.9	0.3	-1.6	-1.3	-2.5	-0.2	-0.7	-2.4	-1.4	-1.1	-1.5	-2.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	1.0	0.0	-0.2	0.2	1.0	1.0	0.3	-0.6	0.6	-0.1	-0.1	0.5	0.6
Headache pain in last month	0.3	0.4	1.8	0.7	-0.7	-1.3	-0.1	-1.0	0.7	0.0	-0.4	-0.5	-0.4	-0.6	-0.4	0.6
Gout (self-reported)	0.3	0.4	2.2	-1.5	0.6	0.8	-0.1	0.1	-0.3	0.3	0.4	-0.1	-1.1	-0.1	-0.2	-0.5
Medication: Amlodipine	0.3	0.4	2.7	0.4	1.7	-0.3	0.4	-0.6	-0.0	-0.3	0.6	0.2	-1.0	-0.3	-0.2	0.2
Age at first live birth	0.3	0.5	2.2	-0.2	0.4	-0.7	-0.4	0.5	-1.2	-0.4	-0.6	-0.2	0.2	-0.9	-0.9	-1.5
Medication: Allopurinol	0.3	0.4	2.4	-1.6	-0.6	0.1	-0.3	-0.6	-0.7	-0.1	-0.2	-0.3	-1.1	-0.3	-0.3	-0.6
Eye problems/disorders: Cataract	0.3	0.3	1.8	-0.1	0.7	0.6	0.3	0.6	0.4	0.7	1.3	0.6	0.5	0.2	0.3	-0.1
Smoking status: Current	0.3	0.5	2.0	-0.4	-0.4	-1.2	-0.4	-0.8	0.0	-1.4	-1.0	-0.2	0.5	-0.4	-0.3	0.3
Average weekly champagne plus white wine intake	0.3	0.4	2.1	-1.4	-1.1	-0.4	0.0	-0.5	-0.3	-0.8	-0.5	0.1	0.5	0.4	0.2	0.2
Miserableness	0.3	0.6	2.9	0.4	1.7	0.2	0.8	0.4	0.4	0.3	0.3	0.4	1.1	1.0	0.5	0.8
Schizophrenia (2018)	0.2	0.5	1.7	0.5	-0.6	1.0	-0.4	0.6	-0.6	0.6	0.0	-0.8	-1.3	-0.1	-0.2	-1.0
Rheumatoid Arthritis	0.2	0.3	1.7	1.3	-0.4	-0.2	0.4	0.7	0.3	0.7	-0.7	0.4	0.5	-0.3	0.3	-0.2
Blood Platelet Count	0.2	2.5	8.5	2.9	2.1	-0.1	1.5	0.7	1.7	0.4	1.3	1.7	0.7	1.4	1.8	1.9
Chronotype (morning person)	0.2	0.5	1.6	1.2	-1.0	0.6	0.3	0.7	0.4	0.6	0.2	0.3	-1.3	0.6	0.5	0.5
Supplements: Zinc	0.2	0.2	1.0	0.3	-0.1	0.4	0.2	0.8	0.2	1.0	-0.1	-0.1	-1.0	0.0	-0.0	-0.2
Current tobacco smoking	0.2	0.3	1.4	-0.4	-0.4	-1.0	-0.2	-0.6	0.1	-1.2	-0.9	-0.1	0.2	-0.4	-0.2	0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	1.8	0.1	-0.2	0.2	-0.5	-0.4	-0.1	0.4	-1.3	-0.3	-0.6	-0.1	0.0	-0.2
High blood pressure (mother)	0.2	0.3	1.2	0.7	0.0	-0.1	0.0	-0.0	1.1	0.6	0.5	0.3	0.6	0.4	0.8	0.9
Medication: Simvastatin	0.2	0.3	1.4	-0.4	0.9	0.3	0.6	0.5	-0.1	0.2	1.2	0.3	0.3	0.2	0.0	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.5	-0.9	0.5	-0.3	-0.1	-0.2	-0.0	-1.2	-0.4	-0.0	0.5	0.0	-0.1	0.5
Medication: Lansoprazole	0.2	0.3	1.1	-0.1	0.1	-0.5	0.4	-0.6	1.0	-0.5	-0.3	0.4	0.3	-0.0	0.4	1.1
Lung cancer (father)	0.2	0.3	0.9	-0.4	0.9	-0.3	0.5	0.4	0.5	0.3	0.6	0.6	0.8	-0.0	0.2	0.4
Peak expiratory flow (PEF)	0.2	0.5	1.9	1.4	-0.9	1.1	0.7	0.3	-0.4	1.1	0.5	0.2	0.2	0.5	0.1	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.5	-0.2	-0.6	-1.0	-0.7	0.0	0.2	-0.5	-1.2	-0.1	0.4	-0.4	-0.1	0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.1	0.4	-0.7	-1.1	-0.6	0.2	0.6	-0.2	-0.3	-0.2	-0.3	-0.8	0.3	0.3
Number of full brothers	0.2	0.3	1.3	1.1	0.5	-0.6	-0.3	-0.1	0.5	-0.7	0.2	0.2	0.0	-0.4	-0.5	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	1.0	1.0	0.1	0.5	-0.5	-0.4	0.5	0.3	-0.9	-0.4	-0.7	0.1	-0.0	0.4
Pulse wave peak to peak time	0.2	0.3	0.9	0.6	0.7	0.9	0.6	-0.3	0.2	0.8	-0.1	-0.1	-0.3	0.7	0.5	0.3
Shortness of breath walking on level ground	0.2	0.3	0.7	0.9	-0.1	-0.8	-0.5	0.0	0.4	-0.8	0.2	0.5	0.5	-0.1	0.3	0.6
Neck or shoulder pain in last month	0.2	0.3	0.8	-0.1	-0.8	0.2	0.9	-0.1	0.6	0.5	0.9	0.3	0.3	0.4	-0.0	0.7
Migraine (self-reported)	0.2	0.3	1.0	0.6	-0.7	-0.0	0.5	-0.2	-0.0	-0.7	0.7	0.6	1.0	0.5	0.4	0.5
Comparative height size at age 10	0.2	1.2	4.2	0.3	-2.0	1.6	1.3	0.8	-0.2	1.5	1.3	0.4	0.6	0.9	0.5	-0.3
Number of full sisters	0.2	0.3	1.4	0.1	1.2	-0.1	0.1	0.2	0.6	-0.7	0.2	0.4	0.2	0.2	0.4	1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	0.4	0.4	0.2	0.3	0.2	0.7	0.1	0.2	0.8	0.8	-0.1	-0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	2.1	1.5	-0.4	-1.0	-0.1	-0.4	0.3	0.9	0.4	0.4	-0.7	-0.4	0.7	-0.1
Loneliness, isolation	0.2	0.2	0.6	0.6	-0.1	0.2	0.4	0.7	0.4	0.7	-0.1	0.6	0.8	0.1	0.4	-0.0
Friendships satisfaction	0.2	0.3	1.2	1.0	0.3	-0.6	-0.1	-0.5	0.4	0.2	-1.1	-0.4	-0.4	-0.2	-0.0	0.3
Back pain experienced in last month	0.2	0.3	1.4	0.5	0.1	0.4	1.2	0.1	-0.2	-0.5	0.8	0.6	0.5	0.7	-0.1	0.4
Blood Eosinophil Count	0.1	1.1	4.5	-0.3	-0.2	1.5	1.3	1.1	0.6	2.1	1.1	0.7	0.2	1.4	1.0	0.4
Heel T-Score	0.1	0.4	1.4	-0.8	-0.7	-0.9	-0.2	0.6	0.4	-1.0	-0.1	0.2	1.2	-0.2	-0.5	0.6
Height	0.1	1.8	5.9	-1.8	-1.9	1.3	-0.8	-0.4	-2.4	-0.3	-0.5	-1.7	-0.4	-0.3	-1.1	-2.1
Tanning	0.1	1.4	2.4	-1.4	0.6	-1.5	-1.2	-1.3	-0.8	-1.0	-1.2	-1.3	-1.0	-1.4	-1.6	-0.7
Vitamin and mineral supplements	0.1	0.2	0.8	0.2	0.3	-0.3	-0.3	-0.7	-0.9	0.1	0.4	-0.3	-0.1	0.1	-0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	1.0	-0.1	-0.3	0.0	0.5	0.1	-0.3	-0.8	-0.4	0.4	1.0	0.3	-0.1	0.3
Supplements: Glucosamine	0.1	0.1	0.6	-0.1	-0.6	0.2	0.4	0.1	-0.0	-0.2	0.3	0.2	0.8	-0.1	-0.4	-0.1
Sitting height	0.1	0.8	3.2	0.5	-1.8	1.0	0.3	0.2	-0.1	1.7	1.3	-0.5	-0.7	-0.1	0.1	-0.7
Age at last live birth	0.1	0.2	0.7	0.8	-0.3	-0.1	0.3	0.6	0.3	0.3	-0.2	0.4	0.8	-0.0	-0.0	0.1
Age started oral contraceptive pill	0.1	0.2	0.8	-0.6	-0.9	0.0	-0.4	0.3	-0.2	-0.2	-0.2	0.0	0.0	-0.4	0.1	-0.5
Ever depressed for a whole week	0.1	0.1	0.4	-0.2	0.3	-0.5	0.0	0.0	0.5	-0.1	0.0	-0.0	0.6	0.0	0.1	0.5
Cholesterol lowering medication	0.1	0.1	0.5	0.0	0.1	-0.7	-0.1	0.2	0.7	0.2	0.2	-0.1	-0.0	-0.1	-0.0	0.5
Hair Pigment	0.0	1.2	3.3	1.8	0.0	0.0	1.0	1.0	1.4	0.3	0.8	1.2	0.9	1.2	1.2	1.8

Hub : Genes

ZCCHC4

Models

Trait associations