TWAS hub - RBPJ

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0230	3.2e-04	0.011	0.031	0.014	0.029	0.012	0.0160	9.9e-05	7.0e-03	1.5e-04	1.1e-02
2	ROSMAP	Brain Pre-frontal Cortex	0.0981	0.0259	8.3e-06	0.018	0.046	0.042	0.049	0.034	0.0021	1.3e-06	3.3e-06	5.3e-07	2.7e-05
3	TCGA	Bladder Urothelial Carcinoma	0.1530	0.0750	6.0e-03	-0.002	0.038	0.030	NA	-0.003	0.5300	3.3e-04	1.3e-03	NA	6.9e-01
4	TCGA	Brain Lower Grade Glioma	0.0751	0.0440	9.8e-03	-0.001	0.003	0.001	NA	-0.002	0.3900	1.4e-01	2.6e-01	NA	6.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Waist Hip Ratio (WHR)	8.7	38.9	55.6	7.1	7.5	-1.5	6.9
Breast cancer (self-reported)	4.9	5.8	12.3	-2.0	-3.5	1.1	-2.4
Impedance of leg (left)	4.6	22.1	50.7	3.8	7.1	0.2	4.8
Age at last live birth	4.4	6.4	12.6	3.1	1.8	-3.6	0.7
Impedance of leg (right)	4.3	20.8	42.9	4.3	6.5	-0.5	4.6
Impedance of whole body	3.8	19.3	44.5	3.4	6.7	0.3	4.6
Age at first live birth	3.4	6.0	14.6	2.9	1.0	-3.8	0.2
Glaucoma (self-reported)	3.1	3.6	7.8	2.8	1.1	-0.4	2.3
Pain type(s) experienced in last month: Hip pain	2.9	3.6	8.4	-0.1	-2.2	1.2	-2.9
Ever depressed for a whole week	2.9	3.6	4.2	-1.8	-1.7	-2.0	-2.0
Number of incorrect matches in round	2.8	4.6	12.1	2.2	3.5	0.9	0.7
Headache pain in last month	2.8	4.8	7.7	2.4	2.8	0.9	2.2
Medication: Gliclazide	2.8	3.1	6.5	2.6	-0.5	-2.3	0.7
Qualifications: College or University degree	2.7	8.5	12.0	3.5	3.4	-1.7	2.7
Schizophrenia (2014)	2.6	5.8	15.8	-1.6	-1.6	-1.6	-4.0
Triglycerides	2.6	4.3	10.0	3.2	1.7	-0.5	2.0
Alzheimer’s Disease (in mother)	2.5	2.9	9.2	0.8	0.9	3.0	1.0
Severe depression (siblings)	2.5	2.8	6.9	-0.6	1.9	2.6	0.7
Gout (self-reported)	2.5	3.5	7.3	2.7	0.7	-0.7	2.4
Commuting to job workplace: Cycle	2.5	3.0	8.3	1.1	1.6	0.0	2.9
Heart disease (siblings)	2.4	3.0	6.1	0.5	-1.9	1.4	-2.5
Schizophrenia (2018)	2.3	4.7	10.0	-2.4	-1.7	-0.3	-3.2
Coronary Artery Disease (CAD)	2.3	2.7	5.1	2.1	1.2	-0.1	2.3
Impedance of arm (left)	2.2	10.2	24.0	2.7	4.9	-0.2	3.1
Smoking status: Current	2.2	3.6	6.2	-2.5	-1.2	-1.6	-2.0
Ever had prostate specific antigen (PSA) test	2.2	2.6	6.2	-1.0	-1.0	2.5	-1.5
Age at First Birth	2.1	3.0	8.1	0.7	-1.1	-2.8	-1.4
Current tobacco smoking	2.1	3.4	6.1	-2.5	-1.4	-1.3	-2.0
Number of full brothers	2.1	2.6	9.3	-0.3	-0.8	0.7	-3.0
Wears glasses or contact lenses	2.1	2.5	4.8	-0.3	1.2	2.2	1.8
Maternal smoking around birth	2.0	2.9	6.5	-1.7	-1.4	0.5	-2.5
Father’s age at death	2.0	2.7	6.8	0.9	-0.2	-1.8	2.6
Qualifications: A levels/AS levels or equivalent	2.0	4.5	9.0	1.2	3.0	-1.3	2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	5.7	-0.2	-2.0	-0.7	-2.4
Number of children fathered	2.0	2.2	6.7	-0.5	-2.6	-0.1	-1.4
Medication: Seretide 50 evohaler	2.0	2.3	7.2	2.7	0.8	0.4	1.1
Leg predicted mass (right)	2.0	10.4	17.4	-4.0	-4.2	-1.4	-2.4
Hypothyroidism (self reported)	1.9	4.3	13.6	3.7	-0.2	-1.9	0.2
Had menopause	1.9	2.3	8.3	0.5	0.6	2.9	0.7
Impedance of arm (right)	1.9	9.0	23.3	2.4	4.8	0.2	2.6
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	10.0	3.2	-0.1	-2.2	-0.2
Leg fat-free mass (right)	1.9	10.1	17.0	-4.0	-4.1	-1.4	-2.4
Illnesses of mother	1.8	2.3	5.2	-0.1	-1.9	-2.3	-0.6
Heel T-Score	1.7	13.2	25.3	5.0	3.8	-1.7	3.2
Leg fat-free mass (left)	1.7	9.2	16.6	-3.5	-4.1	-1.6	-2.3
Sitting height	1.7	12.3	29.2	-5.4	-3.2	-1.5	-2.7
Leg predicted mass (left)	1.7	8.9	16.0	-3.4	-4.0	-1.6	-2.3
Lung cancer (father)	1.7	2.0	4.0	2.0	1.6	-1.0	0.8
Medication: Allopurinol	1.7	2.3	6.1	1.5	0.8	-0.4	2.5
Number of operations (self-reported)	1.7	2.5	3.6	-1.9	-1.9	1.6	-0.0
Age started oral contraceptive pill	1.7	2.2	4.5	1.9	0.7	0.1	2.1
Basal cell carcinoma (self-reported)	1.7	2.1	3.6	-1.9	-0.3	1.9	-1.0
Serious illness, injury or assault to yourself	1.6	1.9	3.4	-1.6	-1.9	0.6	1.2
Heart attack	1.6	2.0	5.1	-0.6	1.5	2.3	0.5
Trunk fat-free mass	1.6	9.2	20.2	-3.0	-4.5	-1.8	-2.2
Trunk predicted mass	1.6	9.0	19.5	-3.0	-4.4	-1.8	-2.1
Medication: Ibuprofen	1.6	1.9	4.5	0.9	2.1	-0.9	1.2
Whole body water mass	1.6	9.1	18.3	-3.4	-4.3	-1.5	-2.2
Heart attack/myocardial infarction (self-reported)	1.6	2.1	5.4	-0.6	1.5	2.3	0.5
Type 2 Diabetes (T2D) (2012)	1.5	1.7	4.1	1.1	-0.6	-1.0	2.0
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	6.2	-2.5	0.1	-0.9	-0.2
Whole body fat-free mass	1.5	8.8	18.0	-3.2	-4.2	-1.6	-2.1
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	4.9	0.2	1.1	2.2	1.8
Medication: Levothyroxine sodium	1.4	2.4	5.0	2.2	0.7	-1.9	-0.5
Basal metabolic rate	1.4	7.5	14.4	-3.1	-3.8	-1.6	-1.8
Bipolar Disorder or Schizophrenia	1.3	3.2	6.9	-1.5	-1.3	-1.4	-2.6
Average weekly spirits intake	1.3	1.7	4.9	-0.4	-0.6	1.1	-2.2
Falls in the last year	1.3	1.8	4.3	-0.1	0.4	1.7	2.1
Noisy workplace	1.3	1.6	5.8	-0.1	-0.7	-0.0	-2.4
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	4.1	1.0	2.0	0.1	1.2
Mean time to correctly identify matches	1.3	2.4	7.0	1.2	2.6	1.0	0.0
Heart disease (mother)	1.3	1.6	2.7	-1.6	0.4	1.6	-0.9
Ovarian Cancer	1.2	1.6	3.8	2.0	0.4	-1.4	-0.8
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	4.7	0.1	-0.7	-2.2	-0.2
High blood pressure (siblings)	1.2	1.8	3.6	-1.6	0.7	1.9	-0.7
Arm fat-free mass (right)	1.2	6.1	12.5	-2.9	-3.5	-1.3	-1.4
Migraine (self-reported)	1.2	1.5	4.6	0.3	-1.1	-2.1	-0.2
Medication: Aspirin	1.2	1.5	4.2	0.2	1.3	2.1	0.4
Ever had bowel cancer screening	1.2	1.4	5.3	-0.0	-0.5	2.3	0.0
Illnesses of father: None of the above (group 1)	1.2	1.5	3.0	-0.2	-1.5	-0.8	-1.7
Guilty feelings	1.2	1.7	6.0	-0.5	-0.8	2.5	0.1
Eye problems/disorders: Glaucoma	1.2	1.4	3.1	1.8	0.7	-0.4	1.3
Arm predicted mass (left)	1.2	6.3	12.5	-2.9	-3.5	-1.0	-1.7
LDL Cholesterol	1.1	1.7	4.6	1.2	-2.2	0.5	-0.5
Systolic Blood Pressure	1.1	5.3	8.0	-1.3	2.8	-1.9	2.8
Hand grip strength (left)	1.1	2.8	8.1	-0.0	-1.2	-2.9	-1.3
Medication: Ramipril	1.1	1.4	2.1	-1.4	-0.5	1.4	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.0	-0.5	-1.0	-0.8	-2.2
Peak expiratory flow (PEF)	1.1	2.6	4.2	-2.0	-1.8	1.1	-1.3
Medication: Amlodipine	1.1	1.5	4.6	0.5	-0.8	-0.7	2.1
Arm predicted mass (right)	1.1	5.6	11.7	-2.8	-3.4	-1.3	-1.3
Smoking status: Previous	1.1	1.7	6.0	-0.3	-0.2	2.5	0.8
Mother’s age at death	1.1	1.4	3.1	1.8	0.7	-0.3	1.3
Arm fat-free mass (left)	1.1	5.8	13.2	-2.6	-3.6	-1.2	-1.3
Mean Putamen Volume	1.0	1.2	2.2	1.5	1.1	-0.8	0.9
Chronotype (morning person)	1.0	2.3	7.5	-0.4	0.9	0.7	2.7
Medication: Metformin	1.0	1.4	3.5	1.3	0.4	-1.9	-0.3
Hearing difficulty/problems with background noise	1.0	1.6	4.6	0.1	1.2	0.6	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	4.8	1.6	2.2	0.7	1.2
Diabetes (self-reported)	1.0	1.6	2.6	1.6	1.1	-1.3	0.8
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	4.5	-0.3	-0.9	-0.3	-2.1
Illnesses of siblings	1.0	1.4	3.9	0.5	-0.1	-2.0	1.1
Exposure to tobacco smoke at home	1.0	1.1	1.6	1.3	1.2	1.0	0.8
Breastfed as a baby	1.0	1.2	2.6	-0.7	1.1	1.6	-0.7
Tense / ‘highly strung’	1.0	1.6	4.1	0.3	-0.1	2.0	-1.5
Shortness of breath walking on level ground	1.0	1.2	2.5	0.8	1.2	1.6	-0.5
Diabetes diagnosed by doctor	1.0	1.7	2.3	1.2	1.5	-1.3	1.1
Average weekly champagne plus white wine intake	1.0	1.4	5.1	-0.1	2.3	-0.3	0.6
Ever had hysterectomy (womb removed)	0.9	1.0	2.8	-0.7	0.4	1.7	0.7
Pulse rate	0.9	1.4	2.6	-1.2	-0.8	1.0	-1.6
Supplements: Vitamin C	0.9	1.0	1.7	1.3	0.6	-1.2	-0.8
Illnesses of siblings: Diabetes	0.9	1.1	2.5	1.3	1.6	0.2	0.4
Medication: Aspirin	0.9	1.2	3.9	-0.0	0.9	2.0	0.3
Hearing aid user	0.9	1.0	2.1	-0.6	-1.4	1.0	-0.8
High cholesterol (Self-reported)	0.9	1.6	3.0	1.7	-0.1	1.6	-0.8
Alcohol drinker status: Never	0.9	1.0	2.8	-1.0	-0.1	-1.7	-0.5
HDL Cholesterol	0.8	1.3	2.3	-1.5	-1.4	-0.5	-0.7
Lupus	0.8	1.1	3.8	0.1	1.9	-0.8	0.4
Hearing difficulty/problems: Yes	0.8	1.2	2.2	-0.3	1.5	1.5	-0.4
Ever used hormone-replacement therapy (HRT)	0.8	1.0	3.2	-0.3	0.1	1.8	-0.8
Diabetes (father)	0.8	1.0	3.1	0.2	1.8	0.6	-0.6
Diabetes (mother)	0.8	1.1	3.2	1.8	1.0	0.1	0.2
Pack years adult smoking proportion	0.8	1.2	3.4	-0.7	-1.0	0.3	-1.8
Relative age voice broke	0.8	1.2	3.8	0.5	0.0	2.0	-0.8
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.0	-0.1	0.1	-1.1	-1.4
High blood pressure (mother)	0.8	1.1	4.0	0.4	2.0	0.3	0.2
Alcohol usually taken with meals	0.8	1.3	2.6	-1.4	-1.6	-0.2	-0.6
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.1	1.4	1.2	-1.0	0.8
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.5	-1.0	0.1	-0.9	-1.6
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.4	-1.0	-1.2	1.1	0.7
Chest pain or discomfort	0.8	1.2	1.9	0.9	1.4	1.3	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.5	-0.3	-1.2	1.2	-0.7
Osteoarthritis (self-reported)	0.8	1.0	2.0	0.1	-1.4	0.8	-1.2
Ever taken oral contraceptive pill	0.8	0.8	2.5	-0.3	0.6	-1.6	0.7
Financial situation satisfaction	0.8	0.9	1.8	-1.4	1.2	-0.4	-0.7
Cholesterol lowering medication	0.8	1.1	3.2	1.8	1.1	0.3	-0.0
Alzheimer’s Disease (including proxy)	0.7	1.0	3.4	0.4	0.5	1.8	0.5
Prostate Cancer	0.7	1.0	2.1	-1.5	-0.7	0.6	-0.9
Smoking Status	0.7	1.7	3.4	-1.8	-1.2	0.2	-1.4
Neuroticism	0.7	1.8	3.7	-0.8	-1.2	1.9	-1.2
Relative age of first facial hair	0.7	1.3	2.7	0.1	-1.2	1.6	-1.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.8	1.6	-0.7	-0.7	0.9	-1.3
Systolic blood pressure, automated reading	0.7	2.1	3.5	-1.5	1.6	-0.4	1.9
Medication for hormone replacement therapy	0.7	0.7	1.4	1.2	0.8	-0.0	-1.0
Vitamin and mineral supplements	0.7	0.9	1.9	-1.3	-0.1	-0.0	1.4
Townsend deprivation index at recruitment	0.7	1.0	3.1	0.5	0.3	1.8	0.8
Average weekly fortified wine intake	0.7	0.9	1.8	-1.2	-0.2	-0.3	-1.4
Multivitamins +/- minerals	0.7	0.8	2.9	0.7	-0.0	-0.1	-1.7
Chronic bronchitis/emphysema (father)	0.7	0.8	1.4	-1.2	-0.5	0.7	-1.0
Forced vital capacity (FVC)	0.7	2.6	5.8	-0.8	-1.7	-2.4	-0.9
Medication: Simvastatin	0.7	1.1	3.9	2.0	-0.1	0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.8	0.5	1.0	0.6	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.7	2.2	-1.5	-0.5	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	4.9	-0.6	-1.6	-2.2	-1.2
Forced vital capacity (FVC), Best measure	0.7	2.5	6.6	-0.7	-1.5	-2.6	-0.9
Leg fat percentage (right)	0.7	2.5	4.1	1.5	2.0	-0.1	1.9
Eye problems/disorders: None of the above	0.7	0.8	1.3	-0.3	0.9	-1.2	-0.9
Pulse rate, automated reading	0.7	2.4	4.9	-0.9	-1.6	1.1	-2.2
Comparative height size at age 10	0.7	4.1	7.8	-2.8	-2.4	-1.5	-0.6
Family relationship satisfaction	0.7	0.8	2.4	0.7	1.5	-0.6	0.2
Hypertension (Self-reported)	0.7	1.8	5.2	0.5	0.4	-1.3	2.3
Mood swings	0.7	1.3	2.1	1.4	1.1	0.6	-1.2
Commuting to job workplace: Walk	0.7	0.8	1.9	0.6	-0.6	-1.4	-0.7
Osteoporosis (self-reported)	0.7	0.8	1.9	-0.8	0.3	0.9	-1.4
Medication: Bendroflumethiazide	0.7	1.0	1.7	-1.0	-1.1	-1.3	-0.3
Medication: Atorvastatin	0.7	0.9	1.7	-0.5	0.2	1.3	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.3	1.5	-0.0	-1.1	0.4
Crohns Disease (2017)	0.6	1.3	4.3	-0.1	-2.1	-0.8	-0.5
Ulcerative Colitis	0.6	0.8	1.9	0.3	1.4	0.8	0.7
BMI	0.6	3.4	5.7	-0.8	-2.4	-1.6	-2.2
Trunk fat percentage	0.6	2.4	5.7	0.7	2.4	0.2	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.1	1.8	1.2	-0.2	0.8
High blood pressure	0.6	1.8	4.4	0.2	-0.1	-1.6	2.1
Supplements: Glucosamine	0.6	0.8	2.9	1.7	0.5	0.4	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.7	1.3	1.1	0.1	0.9
Fluid intelligence score	0.6	1.2	2.4	1.2	0.8	-0.6	-1.6
Depression (self-reported)	0.6	0.7	2.5	0.2	-0.3	0.2	-1.6
Loud music exposure frequency	0.6	0.7	1.3	0.3	1.1	1.1	0.1
Medication: Paracetamol	0.6	1.0	3.8	-0.1	0.3	0.4	-2.0
Body fat percentage	0.6	2.2	4.7	0.8	2.2	0.4	1.9
Exposure to tobacco smoke outside home	0.6	0.7	2.2	-0.2	0.8	1.5	0.3
Neck or shoulder pain in last month	0.6	0.9	1.6	1.1	0.5	0.7	1.3
Number of full sisters	0.6	0.7	1.5	-0.2	0.8	1.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.6	-1.9	0.4	-0.6	-0.8
Commuting to job workplace: Public transport	0.6	0.7	1.7	0.2	1.3	-1.0	-0.4
Medication: Blood pressure	0.6	1.1	2.5	0.2	0.4	-1.6	1.3
Leg fat percentage (left)	0.6	2.3	4.3	1.2	2.1	0.3	1.8
Alcohol drinker status: Previous	0.6	0.7	2.3	0.1	-0.1	1.5	-0.8
Pack years of smoking	0.6	0.8	2.7	-0.2	-0.8	0.3	-1.6
Bipolar Disorder (2018)	0.5	0.8	2.8	0.6	-0.0	-1.7	-0.4
Depressed Affect (Nagel 2018)	0.5	1.1	2.7	1.6	0.2	0.6	-1.2
Neuroticism (Nagel 2018)	0.5	1.2	2.4	1.0	-1.0	0.7	-1.5
Reaction Time	0.5	0.9	3.3	0.3	1.8	-0.1	-0.4
Body Mass Index (BMI) (2010)	0.5	0.7	1.6	0.8	-1.2	-0.4	0.6
HbA1C	0.5	0.5	1.0	0.7	1.0	-0.3	0.7
Rheumatoid Arthritis	0.5	0.8	2.9	0.3	0.1	-1.7	-0.2
Cardiovascular Disease	0.5	1.7	4.1	0.9	0.7	-1.1	2.0
Number of treatments/medications taken	0.5	0.9	1.8	0.9	1.3	0.7	-0.8
Qualifications: CSEs or equivalent	0.5	0.6	1.2	0.0	-0.5	-1.1	-1.0
Waist circumference	0.5	1.8	3.0	1.1	1.1	-1.3	1.7
Financial difficulties in last 2 years	0.5	0.7	1.9	-0.4	0.7	1.4	-0.3
Mouth/teeth dental problems	0.5	0.7	1.2	-0.2	1.1	-0.8	0.9
Pain all over the body in last month	0.5	0.5	1.8	0.5	-1.3	0.3	-0.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.1	-1.3	-1.4	-1.8	-0.8
Happiness	0.5	0.6	2.1	0.2	1.5	-0.2	-0.6
Hair/balding pattern: Pattern 4	0.5	1.3	3.7	-0.8	-1.9	1.0	-0.3
Birth weight of first child	0.5	0.9	2.9	-0.7	0.3	-0.2	-1.7
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.9	-0.4	-1.4	0.5	-0.3
Medication for pain relief, constipation, heartburn	0.5	0.9	2.4	-0.3	-1.6	-0.8	-0.6
Overall health rating	0.5	1.0	1.8	-1.3	-0.8	0.1	-1.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.2	-0.3	-0.3	1.0	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.8	1.3	-0.2	-0.3	0.7
Illnesses of father: Heart disease	0.5	0.7	2.2	0.6	0.1	0.5	1.5
Loneliness, isolation	0.5	0.7	1.8	-0.1	-0.3	-1.0	-1.4
Long-standing illness, disability or infirmity	0.5	0.8	2.2	0.0	-0.8	-0.5	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.1	-1.5	0.2	-0.5	0.2
Mineral and other dietary supplements	0.5	0.6	1.2	-0.5	1.0	-0.1	1.1
Fractured/broken bones in last 5 years	0.5	0.7	2.1	0.3	-1.4	0.2	0.8
Diastolic blood pressure, automated reading	0.5	1.7	3.5	-1.7	-0.6	-1.9	-0.1
Myopia	0.5	0.8	1.8	0.7	-0.9	-1.3	-0.1
Worry (Nagel 2018)	0.4	0.8	1.7	0.3	-1.0	-0.5	-1.3
Major Depression (MDD)	0.4	0.5	0.8	0.6	0.8	-0.9	-0.6
Bipolar Disorder (2011)	0.4	0.4	0.7	0.6	0.7	-0.8	0.1
Crohns Disease (2012)	0.4	0.6	1.9	-0.6	-1.4	0.1	-0.6
Fasting Glucose	0.4	0.5	1.5	0.0	-1.2	0.7	0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.4	0.6	1.5	0.2	-0.1
Lung FVC	0.4	2.1	5.0	0.0	-1.6	-0.9	-2.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	0.9	0.8	0.8	-0.3	0.9
Angina	0.4	0.5	1.5	0.3	0.6	1.2	-0.2
Hand grip strength (right)	0.4	1.2	4.3	0.5	0.1	-2.1	-0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.7	-0.3	-0.4	1.3	-0.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.7	-0.3	-1.3	-1.0	-0.9
Stomach or abdominal pain in last month	0.4	0.5	0.8	0.9	0.9	-0.5	0.4
Past tobacco smoking	0.4	0.7	1.6	0.8	0.4	-1.3	-0.8
Weight	0.4	1.9	3.1	-1.7	-1.8	-1.1	-0.6
Hip circumference	0.4	1.8	4.5	-2.1	-1.1	-0.7	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.6	1.0	0.4	-1.0	0.9	-0.7
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	-0.5	-0.3	-0.9	-0.9
Comparative body size at age 10	0.4	1.1	3.0	0.5	-1.0	-1.7	0.4
Pulse wave peak to peak time	0.4	0.4	1.0	0.3	0.1	0.8	1.0
Angina (self-reported)	0.4	0.6	1.5	0.5	0.7	1.2	0.1
Medication: Omeprazole	0.4	0.5	0.7	0.9	-0.6	-0.2	-0.8
Leg pain on walking	0.4	0.5	1.1	0.4	0.5	1.1	-0.8
Knee pain experienced in last month	0.4	0.6	1.0	-0.7	-1.0	0.8	-0.4
Qualifications: nursing, teaching	0.4	0.6	1.7	-0.4	-0.7	-0.2	-1.3
Eye problems/disorders: Cataract	0.4	0.5	1.3	0.7	-1.1	-0.3	-0.0
Back pain experienced in last month	0.4	0.6	1.2	-1.1	-0.3	0.2	-1.0
Number of self-reported non-cancer illnesses	0.4	0.6	1.1	0.7	-0.5	-0.8	1.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	0.5	-0.9	0.7	-0.7
Illnesses of father: High blood pressure	0.4	0.5	1.5	-0.5	0.6	1.2	0.3
Average weekly beer plus cider intake	0.4	0.5	1.6	0.5	1.2	-0.4	0.4
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.0	0.1	-0.1	0.8	-2.0
Supplements: Calcium	0.4	0.4	0.7	-0.3	-0.6	0.8	-0.8
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.9	0.7	1.7	-0.5	0.6
Irritable Bowel Disease (IBD)	0.3	0.8	1.9	-0.4	-1.4	-0.4	-0.9
Breast Cancer	0.3	0.6	0.8	0.9	-0.8	-0.9	0.4
Primary Biliary Cirrhosis	0.3	0.4	0.8	-0.6	-0.6	0.5	-0.9
Blood White Count	0.3	2.6	6.6	-1.1	-0.7	-2.6	-1.4
Sensitivity / hurt feelings	0.3	0.4	1.7	0.2	-0.1	1.3	0.1
Taking other prescription medications	0.3	0.4	0.8	0.8	-0.5	-0.3	-0.9
Medication: Atenolol	0.3	0.3	0.8	-0.9	-0.7	-0.0	0.1
Nervous feelings	0.3	0.5	1.0	-0.3	-1.0	-0.8	-0.5
Had other major operations	0.3	0.4	0.7	-0.2	-0.7	-0.8	0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	0.3	0.3	-0.4	-0.9
Qualifications: None of the above	0.3	0.7	1.6	-0.2	-1.2	1.3	0.1
Neuroticism score	0.3	0.7	2.1	0.1	-0.2	1.5	-0.9
Asthma	0.3	0.5	1.6	-0.6	0.2	0.3	1.3
Medication: Cholesterol lowering	0.3	0.5	1.0	1.0	-0.5	0.9	0.2
Medication: Lansoprazole	0.3	0.3	1.2	-0.0	0.1	-0.3	-1.1
Length of working week for main job	0.3	0.3	0.8	-0.9	0.2	0.1	0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.3	-0.2	0.5	0.2	-1.1
Blood clot in the leg (DVT)	0.3	0.4	1.0	0.5	-0.2	-0.6	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	-0.1	0.8	-1.1	-0.3
Alcohol intake frequency.	0.3	0.8	1.4	-1.1	-1.2	-0.6	-0.5
Had major operations	0.3	0.3	0.8	-0.4	-0.9	0.3	0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.8	0.4	0.7	-0.1	0.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-0.6	-0.1	1.0	0.3
Friendships satisfaction	0.3	0.4	1.1	0.7	0.3	0.0	-1.0
Medication for cholesterol	0.3	0.4	0.6	-0.7	-0.8	0.2	-0.5
Miserableness	0.3	0.6	1.2	0.5	-0.0	1.0	-1.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	1.0	-0.7	-0.0	-0.5
Medication: Paracetamol	0.3	0.5	1.3	-0.3	0.6	-0.4	-1.1
Ever smoked	0.3	0.5	1.3	-1.1	-0.8	-0.5	0.2
Irritability	0.3	0.5	1.7	1.3	0.1	0.5	0.5
Depression (Nagel 2018)	0.2	0.3	1.0	1.0	0.2	0.1	0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.3	0.4	-0.5	-0.4
Ulcerative Colitis (UC)	0.2	0.3	0.7	-0.6	-0.3	0.2	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.1	0.6	1.1	-0.3	-0.2
Blood Platelet Count	0.2	2.5	8.1	0.5	2.8	-1.0	0.9
Lung FEV1/FVC ratio	0.2	1.1	3.7	-0.3	-0.3	1.9	0.6
Tanning	0.2	2.2	5.0	-1.6	-2.2	1.1	-0.3
Supplements: Zinc	0.2	0.2	0.6	-0.3	0.8	0.5	0.1
Medication: Co-codamol	0.2	0.2	0.3	0.1	0.6	0.6	-0.3
Body mass index (BMI)	0.2	0.9	2.0	-0.7	-1.4	-0.5	-0.8
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	-0.1	0.8	-0.3	-0.6
Time employed in main current job	0.2	0.3	0.7	0.1	-0.5	0.8	0.2
Hair/balding pattern: Pattern 3	0.2	0.3	1.0	1.0	0.6	0.1	0.2
Prospective memory result	0.2	0.2	0.5	0.3	0.7	-0.5	0.3
Standing height	0.2	2.2	4.7	-2.2	-1.0	-1.7	0.5
Pulse wave reflection index	0.2	0.3	0.7	0.8	0.5	0.1	0.4
Worry too long after embarrassment	0.2	0.3	0.7	-0.6	-0.0	-0.6	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	0.3	-0.1	0.8	0.0
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.0	0.6	-0.4	0.8
Medication: Blood pressure	0.2	0.3	0.8	-0.5	-0.9	-0.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.1	0.3	0.8	0.4
Asthma (self-reported)	0.2	0.4	1.4	-0.4	0.3	0.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.0	-0.3	-1.0	-0.7	-0.6
Risk taking	0.2	0.3	0.5	0.4	0.6	-0.7	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	0.1	-0.3	-0.6	0.7
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	-0.5	0.3	-0.2	-0.3
Height	0.1	2.3	6.7	-2.6	-0.8	-1.4	0.3
Allergy or Eczema	0.1	0.3	0.6	-0.3	-0.6	0.2	-0.8
Respiratory disease	0.1	0.2	0.4	-0.6	0.0	0.4	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.1	0.6	-0.0	-0.1
Age when periods started (menarche)	0.1	0.3	0.6	-0.0	0.8	0.6	0.6
Trunk fat mass	0.1	0.5	0.9	-0.3	0.9	-0.4	0.9
Allergy	0.1	0.2	0.4	0.6	0.0	0.4	-0.4
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.5	0.3	0.3	0.0
Worrier / anxious feelings	0.1	0.3	0.5	0.7	-0.3	-0.1	0.7
Number of live births	0.1	0.1	0.5	-0.1	-0.2	0.7	-0.0
Arm fat mass (right)	0.1	0.4	0.9	-0.9	-0.5	-0.7	-0.1
Birth weight	0.1	0.3	0.7	0.4	-0.9	-0.3	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.3	-0.0	0.4	0.5	0.6
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.4	0.4	-0.2	0.5
Health satisfaction	0.1	0.1	0.4	0.3	-0.0	0.2	-0.6
Whole body fat mass	0.1	0.3	0.5	-0.4	0.5	-0.3	0.7
Leg fat mass (right)	0.1	0.3	0.6	-0.1	0.3	-0.8	0.6
Suffer from ‘nerves’	0.1	0.2	0.5	-0.0	-0.1	-0.7	-0.6
Arm fat percentage (left)	0.1	0.3	0.8	0.1	0.9	-0.2	0.5
Average weekly red wine intake	0.1	0.1	0.1	0.3	-0.4	0.3	-0.4
Arm fat mass (left)	0.1	0.4	0.9	-0.9	-0.4	-0.8	-0.1
Medication: Lisinopril	0.1	0.1	0.3	-0.1	-0.5	-0.3	-0.2
Unable to work because of sickness or disability	0.1	0.1	0.2	0.3	0.1	-0.1	0.4
Pain experienced in last month	0.1	0.2	0.3	-0.6	0.5	-0.0	0.5
Neuroticism (2016)	0.0	0.0	0.1	0.0	-0.1	0.3	-0.3
Blood Eosinophil Count	0.0	0.2	0.3	-0.5	0.2	-0.6	0.4
Blood Red Count	0.0	0.2	0.4	-0.3	0.2	-0.4	0.6
Hair Pigment	0.0	0.7	1.8	-0.7	1.4	-0.1	0.5
Fed-up feelings	0.0	0.1	0.2	-0.0	-0.3	0.4	-0.2
Arm fat percentage (right)	0.0	0.1	0.5	-0.0	0.7	-0.1	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.2	-0.1	0.4	0.0	0.1
Leg fat mass (left)	0.0	0.2	0.3	-0.2	0.4	-0.5	0.5

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