Hub : Genes

RBPJ

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0640 0.0230 3.2e-04 0.011 0.031 0.014 0.029 0.012 0.0160 9.9e-05 7.0e-03 1.5e-04 1.1e-02
2 ROSMAP Brain Pre-frontal Cortex 0.0981 0.0259 8.3e-06 0.018 0.046 0.042 0.049 0.034 0.0021 1.3e-06 3.3e-06 5.3e-07 2.7e-05
3 TCGA Bladder Urothelial Carcinoma 0.1530 0.0750 6.0e-03 -0.002 0.038 0.030 NA -0.003 0.5300 3.3e-04 1.3e-03 NA 6.9e-01
4 TCGA Brain Lower Grade Glioma 0.0751 0.0440 9.8e-03 -0.001 0.003 0.001 NA -0.002 0.3900 1.4e-01 2.6e-01 NA 6.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.8 2.8 0.6 -0.0 -1.7 -0.4
Bipolar Disorder or Schizophrenia 1.3 3.2 6.9 -1.5 -1.3 -1.4 -2.6
Depressed Affect (Nagel 2018) 0.5 1.1 2.7 1.6 0.2 0.6 -1.2
Depression (Nagel 2018) 0.2 0.3 1.0 1.0 0.2 0.1 0.6
Intelligence (Savage-Jansen 2018) 0.3 1.0 2.9 0.7 1.7 -0.5 0.6
Neuroticism (Nagel 2018) 0.5 1.2 2.4 1.0 -1.0 0.7 -1.5
Schizophrenia (2018) 2.3 4.7 10.0 -2.4 -1.7 -0.3 -3.2
Schizophrenia vs Biploar Disorder 0.1 0.1 0.3 -0.5 0.3 -0.2 -0.3
Worry (Nagel 2018) 0.4 0.8 1.7 0.3 -1.0 -0.5 -1.3
Alzheimer’s Disease (in mother) 2.5 2.9 9.2 0.8 0.9 3.0 1.0
Alzheimer’s Disease (in father) 0.2 0.2 0.3 -0.3 0.4 -0.5 -0.4
Alzheimer’s Disease (including proxy) 0.7 1.0 3.4 0.4 0.5 1.8 0.5
Crohns Disease (2017) 0.6 1.3 4.3 -0.1 -2.1 -0.8 -0.5
Irritable Bowel Disease (IBD) 0.3 0.8 1.9 -0.4 -1.4 -0.4 -0.9
Ulcerative Colitis (UC) 0.2 0.3 0.7 -0.6 -0.3 0.2 -0.8
Major Depression (MDD) 0.4 0.5 0.8 0.6 0.8 -0.9 -0.6
Reaction Time 0.5 0.9 3.3 0.3 1.8 -0.1 -0.4
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.1 0.6 1.1 -0.3 -0.2
Breast Cancer 0.3 0.6 0.8 0.9 -0.8 -0.9 0.4
Ovarian Cancer 1.2 1.6 3.8 2.0 0.4 -1.4 -0.8
Prostate Cancer 0.7 1.0 2.1 -1.5 -0.7 0.6 -0.9
Age at First Birth 2.1 3.0 8.1 0.7 -1.1 -2.8 -1.4
Bipolar Disorder (2011) 0.4 0.4 0.7 0.6 0.7 -0.8 0.1
Body Mass Index (BMI) (2010) 0.5 0.7 1.6 0.8 -1.2 -0.4 0.6
Coronary Artery Disease (CAD) 2.3 2.7 5.1 2.1 1.2 -0.1 2.3
Crohns Disease (2012) 0.4 0.6 1.9 -0.6 -1.4 0.1 -0.6
Mean Putamen Volume 1.0 1.2 2.2 1.5 1.1 -0.8 0.9
Fasting Glucose 0.4 0.5 1.5 0.0 -1.2 0.7 0.1
HbA1C 0.5 0.5 1.0 0.7 1.0 -0.3 0.7
HDL Cholesterol 0.8 1.3 2.3 -1.5 -1.4 -0.5 -0.7
LDL Cholesterol 1.1 1.7 4.6 1.2 -2.2 0.5 -0.5
Lupus 0.8 1.1 3.8 0.1 1.9 -0.8 0.4
Neuroticism (2016) 0.0 0.0 0.1 0.0 -0.1 0.3 -0.3
Primary Biliary Cirrhosis 0.3 0.4 0.8 -0.6 -0.6 0.5 -0.9
Rheumatoid Arthritis 0.5 0.8 2.9 0.3 0.1 -1.7 -0.2
Schizophrenia (2014) 2.6 5.8 15.8 -1.6 -1.6 -1.6 -4.0
Triglycerides 2.6 4.3 10.0 3.2 1.7 -0.5 2.0
Type 2 Diabetes (T2D) (2012) 1.5 1.7 4.1 1.1 -0.6 -1.0 2.0
Ulcerative Colitis 0.6 0.8 1.9 0.3 1.4 0.8 0.7
Blood Eosinophil Count 0.0 0.2 0.3 -0.5 0.2 -0.6 0.4
Blood Platelet Count 0.2 2.5 8.1 0.5 2.8 -1.0 0.9
Blood Red Count 0.0 0.2 0.4 -0.3 0.2 -0.4 0.6
Blood White Count 0.3 2.6 6.6 -1.1 -0.7 -2.6 -1.4
Heel T-Score 1.7 13.2 25.3 5.0 3.8 -1.7 3.2
BMI 0.6 3.4 5.7 -0.8 -2.4 -1.6 -2.2
Height 0.1 2.3 6.7 -2.6 -0.8 -1.4 0.3
Waist Hip Ratio (WHR) 8.7 38.9 55.6 7.1 7.5 -1.5 6.9
Systolic Blood Pressure 1.1 5.3 8.0 -1.3 2.8 -1.9 2.8
Smoking Status 0.7 1.7 3.4 -1.8 -1.2 0.2 -1.4
Allergy or Eczema 0.1 0.3 0.6 -0.3 -0.6 0.2 -0.8
Cardiovascular Disease 0.5 1.7 4.1 0.9 0.7 -1.1 2.0
Hypothyroidism (self reported) 1.9 4.3 13.6 3.7 -0.2 -1.9 0.2
Respiratory disease 0.1 0.2 0.4 -0.6 0.0 0.4 0.6
Type 2 Diabetes (T2D) (2018) 0.4 0.7 2.4 0.6 1.5 0.2 -0.1
Lung FEV1/FVC ratio 0.2 1.1 3.7 -0.3 -0.3 1.9 0.6
Lung FVC 0.4 2.1 5.0 0.0 -1.6 -0.9 -2.2
Neuroticism 0.7 1.8 3.7 -0.8 -1.2 1.9 -1.2
Chronotype (morning person) 1.0 2.3 7.5 -0.4 0.9 0.7 2.7
Hair Pigment 0.0 0.7 1.8 -0.7 1.4 -0.1 0.5
Tanning 0.2 2.2 5.0 -1.6 -2.2 1.1 -0.3
Hand grip strength (left) 1.1 2.8 8.1 -0.0 -1.2 -2.9 -1.3
Number of treatments/medications taken 0.5 0.9 1.8 0.9 1.3 0.7 -0.8
Average weekly spirits intake 1.3 1.7 4.9 -0.4 -0.6 1.1 -2.2
Sensitivity / hurt feelings 0.3 0.4 1.7 0.2 -0.1 1.3 0.1
Frequency of depressed mood in last 2 weeks 0.4 0.6 0.9 0.8 0.8 -0.3 0.9
Hearing difficulty/problems: Yes 0.8 1.2 2.2 -0.3 1.5 1.5 -0.4
Relative age of first facial hair 0.7 1.3 2.7 0.1 -1.2 1.6 -1.1
Other serious medical condition/disability diagnosed by doctor 0.7 0.8 1.6 -0.7 -0.7 0.9 -1.3
Ever used hormone-replacement therapy (HRT) 0.8 1.0 3.2 -0.3 0.1 1.8 -0.8
Ever had hysterectomy (womb removed) 0.9 1.0 2.8 -0.7 0.4 1.7 0.7
Systolic blood pressure, automated reading 0.7 2.1 3.5 -1.5 1.6 -0.4 1.9
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 4.7 0.1 -0.7 -2.2 -0.2
Angina 0.4 0.5 1.5 0.3 0.6 1.2 -0.2
Medication for hormone replacement therapy 0.7 0.7 1.4 1.2 0.8 -0.0 -1.0
Vitamin and mineral supplements 0.7 0.9 1.9 -1.3 -0.1 -0.0 1.4
Supplements: Zinc 0.2 0.2 0.6 -0.3 0.8 0.5 0.1
Medication: Co-codamol 0.2 0.2 0.3 0.1 0.6 0.6 -0.3
Medication: Metformin 1.0 1.4 3.5 1.3 0.4 -1.9 -0.3
Diabetes (father) 0.8 1.0 3.1 0.2 1.8 0.6 -0.6
Diabetes (mother) 0.8 1.1 3.2 1.8 1.0 0.1 0.2
Severe depression (siblings) 2.5 2.8 6.9 -0.6 1.9 2.6 0.7
Pack years adult smoking proportion 0.8 1.2 3.4 -0.7 -1.0 0.3 -1.8
Impedance of leg (right) 4.3 20.8 42.9 4.3 6.5 -0.5 4.6
Leg fat-free mass (left) 1.7 9.2 16.6 -3.5 -4.1 -1.6 -2.3
Trunk fat percentage 0.6 2.4 5.7 0.7 2.4 0.2 1.9
Hand grip strength (right) 0.4 1.2 4.3 0.5 0.1 -2.1 -0.4
Townsend deprivation index at recruitment 0.7 1.0 3.1 0.5 0.3 1.8 0.8
Current tobacco smoking 2.1 3.4 6.1 -2.5 -1.4 -1.3 -2.0
Average weekly fortified wine intake 0.7 0.9 1.8 -1.2 -0.2 -0.3 -1.4
Maternal smoking around birth 2.0 2.9 6.5 -1.7 -1.4 0.5 -2.5
Fed-up feelings 0.0 0.1 0.2 -0.0 -0.3 0.4 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.4 0.1 0.6 -0.0 -0.1
Relative age voice broke 0.8 1.2 3.8 0.5 0.0 2.0 -0.8
Taking other prescription medications 0.3 0.4 0.8 0.8 -0.5 -0.3 -0.9
Age when periods started (menarche) 0.1 0.3 0.6 -0.0 0.8 0.6 0.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.7 -0.3 -0.4 1.3 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.1 1.8 1.2 -0.2 0.8
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.0 -0.1 0.1 -1.1 -1.4
Qualifications: CSEs or equivalent 0.5 0.6 1.2 0.0 -0.5 -1.1 -1.0
Serious illness, injury or assault to yourself 1.6 1.9 3.4 -1.6 -1.9 0.6 1.2
High blood pressure 0.6 1.8 4.4 0.2 -0.1 -1.6 2.1
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.7 -0.3 -1.3 -1.0 -0.9
Multivitamins +/- minerals 0.7 0.8 2.9 0.7 -0.0 -0.1 -1.7
Stomach or abdominal pain in last month 0.4 0.5 0.8 0.9 0.9 -0.5 0.4
Supplements: Glucosamine 0.6 0.8 2.9 1.7 0.5 0.4 0.1
Diverticular disease/diverticulitis (self-reported) 1.5 1.8 6.2 -2.5 0.1 -0.9 -0.2
Medication: Atenolol 0.3 0.3 0.8 -0.9 -0.7 -0.0 0.1
Medication: Levothyroxine sodium 1.4 2.4 5.0 2.2 0.7 -1.9 -0.5
Sitting height 1.7 12.3 29.2 -5.4 -3.2 -1.5 -2.7
Chronic bronchitis/emphysema (father) 0.7 0.8 1.4 -1.2 -0.5 0.7 -1.0
High blood pressure (mother) 0.8 1.1 4.0 0.4 2.0 0.3 0.2
Body mass index (BMI) 0.2 0.9 2.0 -0.7 -1.4 -0.5 -0.8
Impedance of leg (left) 4.6 22.1 50.7 3.8 7.1 0.2 4.8
Leg predicted mass (left) 1.7 8.9 16.0 -3.4 -4.0 -1.6 -2.3
Trunk fat mass 0.1 0.5 0.9 -0.3 0.9 -0.4 0.9
Waist circumference 0.5 1.8 3.0 1.1 1.1 -1.3 1.7
Number of incorrect matches in round 2.8 4.6 12.1 2.2 3.5 0.9 0.7
Past tobacco smoking 0.4 0.7 1.6 0.8 0.4 -1.3 -0.8
Alcohol usually taken with meals 0.8 1.3 2.6 -1.4 -1.6 -0.2 -0.6
Nervous feelings 0.3 0.5 1.0 -0.3 -1.0 -0.8 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.7 1.3 1.1 0.1 0.9
Hearing difficulty/problems with background noise 1.0 1.6 4.6 0.1 1.2 0.6 -2.1
Hair/balding pattern: Pattern 2 0.2 0.3 0.7 -0.1 0.8 -0.3 -0.6
Had menopause 1.9 2.3 8.3 0.5 0.6 2.9 0.7
Had other major operations 0.3 0.4 0.7 -0.2 -0.7 -0.8 0.5
Forced vital capacity (FVC) 0.7 2.6 5.8 -0.8 -1.7 -2.4 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.4 4.8 1.6 2.2 0.7 1.2
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.9 0.3 0.3 -0.4 -0.9
Qualifications: None of the above 0.3 0.7 1.6 -0.2 -1.2 1.3 0.1
Financial difficulties in last 2 years 0.5 0.7 1.9 -0.4 0.7 1.4 -0.3
Mouth/teeth dental problems 0.5 0.7 1.2 -0.2 1.1 -0.8 0.9
Heart attack 1.6 2.0 5.1 -0.6 1.5 2.3 0.5
Allergy 0.1 0.2 0.4 0.6 0.0 0.4 -0.4
Pain all over the body in last month 0.5 0.5 1.8 0.5 -1.3 0.3 -0.1
Diabetes (self-reported) 1.0 1.6 2.6 1.6 1.1 -1.3 0.8
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 4.5 -0.3 -0.9 -0.3 -2.1
Medication: Ramipril 1.1 1.4 2.1 -1.4 -0.5 1.4 -1.2
Medication: Simvastatin 0.7 1.1 3.9 2.0 -0.1 0.4 0.3
Fluid intelligence score 0.6 1.2 2.4 1.2 0.8 -0.6 -1.6
Illnesses of siblings 1.0 1.4 3.9 0.5 -0.1 -2.0 1.1
Neuroticism score 0.3 0.7 2.1 0.1 -0.2 1.5 -0.9
Weight 0.4 1.9 3.1 -1.7 -1.8 -1.1 -0.6
Impedance of arm (right) 1.9 9.0 23.3 2.4 4.8 0.2 2.6
Arm fat percentage (right) 0.0 0.1 0.5 -0.0 0.7 -0.1 0.2
Trunk fat-free mass 1.6 9.2 20.2 -3.0 -4.5 -1.8 -2.2
Hip circumference 0.4 1.8 4.5 -2.1 -1.1 -0.7 -0.9
Time employed in main current job 0.2 0.3 0.7 0.1 -0.5 0.8 0.2
Alcohol intake versus 10 years previously 0.1 0.1 0.2 -0.5 0.3 0.3 0.0
Father’s age at death 2.0 2.7 6.8 0.9 -0.2 -1.8 2.6
Worrier / anxious feelings 0.1 0.3 0.5 0.7 -0.3 -0.1 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.8 0.5 1.0 0.6 -1.7
Falls in the last year 1.3 1.8 4.3 -0.1 0.4 1.7 2.1
Hair/balding pattern: Pattern 3 0.2 0.3 1.0 1.0 0.6 0.1 0.2
Number of live births 0.1 0.1 0.5 -0.1 -0.2 0.7 -0.0
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 3.1 -1.3 -1.4 -1.8 -0.8
Pulse rate 0.9 1.4 2.6 -1.2 -0.8 1.0 -1.6
Happiness 0.5 0.6 2.1 0.2 1.5 -0.2 -0.6
Noisy workplace 1.3 1.6 5.8 -0.1 -0.7 -0.0 -2.4
Qualifications: A levels/AS levels or equivalent 2.0 4.5 9.0 1.2 3.0 -1.3 2.4
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.7 2.2 -1.5 -0.5 -0.7 -0.2
Mouth/teeth dental problems: Dentures 0.4 0.6 1.0 0.4 -1.0 0.9 -0.7
Asthma 0.3 0.5 1.6 -0.6 0.2 0.3 1.3
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 4.1 1.0 2.0 0.1 1.2
Medication: Cholesterol lowering 0.3 0.5 1.0 1.0 -0.5 0.9 0.2
Depression (self-reported) 0.6 0.7 2.5 0.2 -0.3 0.2 -1.6
Medication: Lansoprazole 0.3 0.3 1.2 -0.0 0.1 -0.3 -1.1
Prospective memory result 0.2 0.2 0.5 0.3 0.7 -0.5 0.3
Lung cancer (father) 1.7 2.0 4.0 2.0 1.6 -1.0 0.8
Illnesses of mother 1.8 2.3 5.2 -0.1 -1.9 -2.3 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 4.9 -0.6 -1.6 -2.2 -1.2
Pulse wave Arterial Stiffness index 0.4 0.5 0.9 -0.5 -0.3 -0.9 -0.9
Impedance of arm (left) 2.2 10.2 24.0 2.7 4.9 -0.2 3.1
Arm fat mass (right) 0.1 0.4 0.9 -0.9 -0.5 -0.7 -0.1
Trunk predicted mass 1.6 9.0 19.5 -3.0 -4.4 -1.8 -2.1
Standing height 0.2 2.2 4.7 -2.2 -1.0 -1.7 0.5
Length of working week for main job 0.3 0.3 0.8 -0.9 0.2 0.1 0.6
Exposure to tobacco smoke at home 1.0 1.1 1.6 1.3 1.2 1.0 0.8
Breastfed as a baby 1.0 1.2 2.6 -0.7 1.1 1.6 -0.7
Tense / ‘highly strung’ 1.0 1.6 4.1 0.3 -0.1 2.0 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.7 5.0 -0.5 -1.0 -0.8 -2.2
Hair/balding pattern: Pattern 4 0.5 1.3 3.7 -0.8 -1.9 1.0 -0.3
Birth weight of first child 0.5 0.9 2.9 -0.7 0.3 -0.2 -1.7
Peak expiratory flow (PEF) 1.1 2.6 4.2 -2.0 -1.8 1.1 -1.3
Pulse wave reflection index 0.2 0.3 0.7 0.8 0.5 0.1 0.4
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.3 -0.2 0.5 0.2 -1.1
Loud music exposure frequency 0.6 0.7 1.3 0.3 1.1 1.1 0.1
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 2.1 1.4 1.2 -1.0 0.8
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.5 -1.0 0.1 -0.9 -1.6
Blood clot in the leg (DVT) 0.3 0.4 1.0 0.5 -0.2 -0.6 1.0
Medication: Paracetamol 0.6 1.0 3.8 -0.1 0.3 0.4 -2.0
Headache pain in last month 2.8 4.8 7.7 2.4 2.8 0.9 2.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.1 -0.1 0.8 -1.1 -0.3
Glaucoma (self-reported) 3.1 3.6 7.8 2.8 1.1 -0.4 2.3
Gout (self-reported) 2.5 3.5 7.3 2.7 0.7 -0.7 2.4
Hypothyroidism/myxoedema (self-reported) 1.9 3.7 10.0 3.2 -0.1 -2.2 -0.2
Medication: Amlodipine 1.1 1.5 4.6 0.5 -0.8 -0.7 2.1
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.4 -1.0 -1.2 1.1 0.7
Birth weight 0.1 0.3 0.7 0.4 -0.9 -0.3 -0.2
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.3 -0.0 0.4 0.5 0.6
High blood pressure (siblings) 1.2 1.8 3.6 -1.6 0.7 1.9 -0.7
Forced vital capacity (FVC), Best measure 0.7 2.5 6.6 -0.7 -1.5 -2.6 -0.9
Body fat percentage 0.6 2.2 4.7 0.8 2.2 0.4 1.9
Leg fat percentage (right) 0.7 2.5 4.1 1.5 2.0 -0.1 1.9
Arm fat-free mass (right) 1.2 6.1 12.5 -2.9 -3.5 -1.3 -1.4
Exposure to tobacco smoke outside home 0.6 0.7 2.2 -0.2 0.8 1.5 0.3
Comparative body size at age 10 0.4 1.1 3.0 0.5 -1.0 -1.7 0.4
Number of full brothers 2.1 2.6 9.3 -0.3 -0.8 0.7 -3.0
Worry too long after embarrassment 0.2 0.3 0.7 -0.6 -0.0 -0.6 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.6 5.7 -0.2 -2.0 -0.7 -2.4
Wheeze or whistling in the chest in last year 0.1 0.2 0.3 0.4 0.4 -0.2 0.5
Number of children fathered 2.0 2.2 6.7 -0.5 -2.6 -0.1 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.7 0.3 -0.1 0.8 0.0
Age at first live birth 3.4 6.0 14.6 2.9 1.0 -3.8 0.2
Pulse wave peak to peak time 0.4 0.4 1.0 0.3 0.1 0.8 1.0
Health satisfaction 0.1 0.1 0.4 0.3 -0.0 0.2 -0.6
Shortness of breath walking on level ground 1.0 1.2 2.5 0.8 1.2 1.6 -0.5
Qualifications: College or University degree 2.7 8.5 12.0 3.5 3.4 -1.7 2.7
Eye problems/disorders: None of the above 0.7 0.8 1.3 -0.3 0.9 -1.2 -0.9
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.9 -0.4 -1.4 0.5 -0.3
Emphysema/chronic bronchitis 0.2 0.3 0.6 0.0 0.6 -0.4 0.8
Medication for pain relief, constipation, heartburn 0.5 0.9 2.4 -0.3 -1.6 -0.8 -0.6
Neck or shoulder pain in last month 0.6 0.9 1.6 1.1 0.5 0.7 1.3
Medication: Blood pressure 0.2 0.3 0.8 -0.5 -0.9 -0.1 0.3
Angina (self-reported) 0.4 0.6 1.5 0.5 0.7 1.2 0.1
Migraine (self-reported) 1.2 1.5 4.6 0.3 -1.1 -2.1 -0.2
Medication: Ibuprofen 1.6 1.9 4.5 0.9 2.1 -0.9 1.2
Medication: Allopurinol 1.7 2.3 6.1 1.5 0.8 -0.4 2.5
Medication: Omeprazole 0.4 0.5 0.7 0.9 -0.6 -0.2 -0.8
Medication: Seretide 50 evohaler 2.0 2.3 7.2 2.7 0.8 0.4 1.1
Mean time to correctly identify matches 1.3 2.4 7.0 1.2 2.6 1.0 0.0
Heart disease (mother) 1.3 1.6 2.7 -1.6 0.4 1.6 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.6 0.1 0.3 0.8 0.4
Whole body fat mass 0.1 0.3 0.5 -0.4 0.5 -0.3 0.7
Leg fat mass (right) 0.1 0.3 0.6 -0.1 0.3 -0.8 0.6
Arm predicted mass (right) 1.1 5.6 11.7 -2.8 -3.4 -1.3 -1.3
Pulse rate, automated reading 0.7 2.4 4.9 -0.9 -1.6 1.1 -2.2
Alcohol intake frequency. 0.3 0.8 1.4 -1.1 -1.2 -0.6 -0.5
Comparative height size at age 10 0.7 4.1 7.8 -2.8 -2.4 -1.5 -0.6
Number of full sisters 0.6 0.7 1.5 -0.2 0.8 1.2 0.7
Suffer from ‘nerves’ 0.1 0.2 0.5 -0.0 -0.1 -0.7 -0.6
Overall health rating 0.5 1.0 1.8 -1.3 -0.8 0.1 -1.2
Chest pain or discomfort 0.8 1.2 1.9 0.9 1.4 1.3 0.6
Had major operations 0.3 0.3 0.8 -0.4 -0.9 0.3 0.4
Age at last live birth 4.4 6.4 12.6 3.1 1.8 -3.6 0.7
Family relationship satisfaction 0.7 0.8 2.4 0.7 1.5 -0.6 0.2
Leg pain on walking 0.4 0.5 1.1 0.4 0.5 1.1 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.1 0.2 -0.1 0.4 0.0 0.1
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.2 -0.3 -0.3 1.0 1.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.8 0.4 0.7 -0.1 0.9
Medication: Aspirin 1.2 1.5 4.2 0.2 1.3 2.1 0.4
Supplements: Vitamin C 0.9 1.0 1.7 1.3 0.6 -1.2 -0.8
Knee pain experienced in last month 0.4 0.6 1.0 -0.7 -1.0 0.8 -0.4
Hypertension (Self-reported) 0.7 1.8 5.2 0.5 0.4 -1.3 2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.8 1.3 -0.2 -0.3 0.7
Illnesses of father: Heart disease 0.5 0.7 2.2 0.6 0.1 0.5 1.5
Illnesses of siblings: Diabetes 0.9 1.1 2.5 1.3 1.6 0.2 0.4
Smoking status: Previous 1.1 1.7 6.0 -0.3 -0.2 2.5 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 3.6 -1.9 0.4 -0.6 -0.8
Whole body fat-free mass 1.5 8.8 18.0 -3.2 -4.2 -1.6 -2.1
Leg fat-free mass (right) 1.9 10.1 17.0 -4.0 -4.1 -1.4 -2.4
Arm fat percentage (left) 0.1 0.3 0.8 0.1 0.9 -0.2 0.5
Average weekly red wine intake 0.1 0.1 0.1 0.3 -0.4 0.3 -0.4
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 -0.6 -0.1 1.0 0.3
Mood swings 0.7 1.3 2.1 1.4 1.1 0.6 -1.2
Loneliness, isolation 0.5 0.7 1.8 -0.1 -0.3 -1.0 -1.4
Long-standing illness, disability or infirmity 0.5 0.8 2.2 0.0 -0.8 -0.5 -1.5
Ever had bowel cancer screening 1.2 1.4 5.3 -0.0 -0.5 2.3 0.0
Diabetes diagnosed by doctor 1.0 1.7 2.3 1.2 1.5 -1.3 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.5 -0.3 -1.2 1.2 -0.7
Friendships satisfaction 0.3 0.4 1.1 0.7 0.3 0.0 -1.0
Qualifications: nursing, teaching 0.4 0.6 1.7 -0.4 -0.7 -0.2 -1.3
Commuting to job workplace: Walk 0.7 0.8 1.9 0.6 -0.6 -1.4 -0.7
Eye problems/disorders: Cataract 0.4 0.5 1.3 0.7 -1.1 -0.3 -0.0
Mouth/teeth dental problems: Mouth ulcers 1.5 2.3 4.9 0.2 1.1 2.2 1.8
Medication for cholesterol 0.3 0.4 0.6 -0.7 -0.8 0.2 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 2.1 -1.5 0.2 -0.5 0.2
Back pain experienced in last month 0.4 0.6 1.2 -1.1 -0.3 0.2 -1.0
Mineral and other dietary supplements 0.5 0.6 1.2 -0.5 1.0 -0.1 1.1
Breast cancer (self-reported) 4.9 5.8 12.3 -2.0 -3.5 1.1 -2.4
Asthma (self-reported) 0.2 0.4 1.4 -0.4 0.3 0.3 1.2
Osteoporosis (self-reported) 0.7 0.8 1.9 -0.8 0.3 0.9 -1.4
Osteoarthritis (self-reported) 0.8 1.0 2.0 0.1 -1.4 0.8 -1.2
Medication: Aspirin 0.9 1.2 3.9 -0.0 0.9 2.0 0.3
Medication: Gliclazide 2.8 3.1 6.5 2.6 -0.5 -2.3 0.7
Illnesses of father: None of the above (group 1) 1.2 1.5 3.0 -0.2 -1.5 -0.8 -1.7
Smoking status: Current 2.2 3.6 6.2 -2.5 -1.2 -1.6 -2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.0 -0.3 -1.0 -0.7 -0.6
Whole body water mass 1.6 9.1 18.3 -3.4 -4.3 -1.5 -2.2
Leg predicted mass (right) 2.0 10.4 17.4 -4.0 -4.2 -1.4 -2.4
Arm fat mass (left) 0.1 0.4 0.9 -0.9 -0.4 -0.8 -0.1
Number of self-reported non-cancer illnesses 0.4 0.6 1.1 0.7 -0.5 -0.8 1.1
Average weekly champagne plus white wine intake 1.0 1.4 5.1 -0.1 2.3 -0.3 0.6
Miserableness 0.3 0.6 1.2 0.5 -0.0 1.0 -1.1
Guilty feelings 1.2 1.7 6.0 -0.5 -0.8 2.5 0.1
Wears glasses or contact lenses 2.1 2.5 4.8 -0.3 1.2 2.2 1.8
Ever taken oral contraceptive pill 0.8 0.8 2.5 -0.3 0.6 -1.6 0.7
Hearing aid user 0.9 1.0 2.1 -0.6 -1.4 1.0 -0.8
Mother’s age at death 1.1 1.4 3.1 1.8 0.7 -0.3 1.3
Financial situation satisfaction 0.8 0.9 1.8 -1.4 1.2 -0.4 -0.7
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.7 0.5 -0.9 0.7 -0.7
Commuting to job workplace: Public transport 0.6 0.7 1.7 0.2 1.3 -1.0 -0.4
Eye problems/disorders: Glaucoma 1.2 1.4 3.1 1.8 0.7 -0.4 1.3
Medication: Blood pressure 0.6 1.1 2.5 0.2 0.4 -1.6 1.3
Pain type(s) experienced in last month: Hip pain 2.9 3.6 8.4 -0.1 -2.2 1.2 -2.9
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.0 1.0 -0.7 -0.0 -0.5
High cholesterol (Self-reported) 0.9 1.6 3.0 1.7 -0.1 1.6 -0.8
Medication: Bendroflumethiazide 0.7 1.0 1.7 -1.0 -1.1 -1.3 -0.3
Medication: Paracetamol 0.3 0.5 1.3 -0.3 0.6 -0.4 -1.1
Medication: Lisinopril 0.1 0.1 0.3 -0.1 -0.5 -0.3 -0.2
Medication: Atorvastatin 0.7 0.9 1.7 -0.5 0.2 1.3 -1.3
Illnesses of father: High blood pressure 0.4 0.5 1.5 -0.5 0.6 1.2 0.3
Alcohol drinker status: Never 0.9 1.0 2.8 -1.0 -0.1 -1.7 -0.5
Ever smoked 0.3 0.5 1.3 -1.1 -0.8 -0.5 0.2
Basal metabolic rate 1.4 7.5 14.4 -3.1 -3.8 -1.6 -1.8
Leg fat percentage (left) 0.6 2.3 4.3 1.2 2.1 0.3 1.8
Arm fat-free mass (left) 1.1 5.8 13.2 -2.6 -3.6 -1.2 -1.3
Number of operations (self-reported) 1.7 2.5 3.6 -1.9 -1.9 1.6 -0.0
Average weekly beer plus cider intake 0.4 0.5 1.6 0.5 1.2 -0.4 0.4
Irritability 0.3 0.5 1.7 1.3 0.1 0.5 0.5
Risk taking 0.2 0.3 0.5 0.4 0.6 -0.7 -0.0
Ever had prostate specific antigen (PSA) test 2.2 2.6 6.2 -1.0 -1.0 2.5 -1.5
Fractured/broken bones in last 5 years 0.5 0.7 2.1 0.3 -1.4 0.2 0.8
Age started oral contraceptive pill 1.7 2.2 4.5 1.9 0.7 0.1 2.1
Diastolic blood pressure, automated reading 0.5 1.7 3.5 -1.7 -0.6 -1.9 -0.1
Ever depressed for a whole week 2.9 3.6 4.2 -1.8 -1.7 -2.0 -2.0
Unable to work because of sickness or disability 0.1 0.1 0.2 0.3 0.1 -0.1 0.4
Commuting to job workplace: Cycle 2.5 3.0 8.3 1.1 1.6 0.0 2.9
Myopia 0.5 0.8 1.8 0.7 -0.9 -1.3 -0.1
Vascular/heart problems diagnosed by doctor 0.4 1.2 4.0 0.1 -0.1 0.8 -2.0
Cholesterol lowering medication 0.8 1.1 3.2 1.8 1.1 0.3 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.3 1.5 -0.0 -1.1 0.4
Pain experienced in last month 0.1 0.2 0.3 -0.6 0.5 -0.0 0.5
Supplements: Calcium 0.4 0.4 0.7 -0.3 -0.6 0.8 -0.8
Basal cell carcinoma (self-reported) 1.7 2.1 3.6 -1.9 -0.3 1.9 -1.0
Heart attack/myocardial infarction (self-reported) 1.6 2.1 5.4 -0.6 1.5 2.3 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.5 0.1 -0.3 -0.6 0.7
Heart disease (siblings) 2.4 3.0 6.1 0.5 -1.9 1.4 -2.5
Alcohol drinker status: Previous 0.6 0.7 2.3 0.1 -0.1 1.5 -0.8
Pack years of smoking 0.6 0.8 2.7 -0.2 -0.8 0.3 -1.6
Impedance of whole body 3.8 19.3 44.5 3.4 6.7 0.3 4.6
Leg fat mass (left) 0.0 0.2 0.3 -0.2 0.4 -0.5 0.5
Arm predicted mass (left) 1.2 6.3 12.5 -2.9 -3.5 -1.0 -1.7