[Hub]/) : Traits : Impedance of leg (right) : ← →

chr1:38,762,381-40,737,589

Best TWAS P=2.77e-20 · Best GWAS P=6.41e-18 conditioned to 0.306

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	BMP8A	0.05	0.01	blup	48	0.04	6.8e-05	-8.07	-9.2	2.8e-20	0.74	0.00	0.98	TRUE
33	GTEx	Ovary	RP11-69E11.4	0.25	0.05	enet	11	0.03	6.7e-02	-7.40	-8.4	4.4e-17	0.68	0.05	0.38	TRUE
47	YFS	Blood	AKIRIN1	0.22	0.14	enet	44	0.26	3.0e-83	-4.98	-5.5	4.7e-08	0.06	1.00	0.00	TRUE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BMP8A	0.04	0.03	blup	48	0.04	3.5e-05	-6.95	-9.1	1.2e-19	0.73	0.02	0.97	FALSE
6	GTEx	Adrenal Gland	PABPC4	0.20	0.09	lasso	8	0.06	3.0e-03	-7.23	8.9	7.4e-19	-0.81	0.03	0.90	FALSE
61	The Cancer Genome Atlas	Thyroid Carcinoma	PABPC4	0.09	0.07	enet	5	0.08	4.1e-08	-7.23	8.8	1.1e-18	-0.65	0.00	1.00	FALSE
7	GTEx	Adrenal Gland	RP11-69E11.4	0.11	0.05	lasso	3	0.00	2.4e-01	-7.29	-8.6	9.2e-18	0.57	0.04	0.63	FALSE
46	NTR	Blood	PABPC4	0.01	0.00	blup	383	0.00	2.8e-02	-7.23	8.4	3.0e-17	-0.73	0.04	0.62	FALSE
45	NTR	Blood	KIAA0754	0.03	0.00	bslmm	366	0.01	1.6e-03	0.98	-8.3	1.1e-16	0.64	0.04	0.90	FALSE
17	GTEx	Breast Mammary Tissue (Female)	PABPC4	0.10	0.00	enet	9	0.01	1.5e-01	-8.54	8.1	5.5e-16	-0.87	0.03	0.48	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PABPC4	0.04	0.05	blup	31	0.04	1.2e-05	-7.33	7.8	5.0e-15	-0.61	0.00	1.00	FALSE
37	GTEx	Skin Sun Exposed Lower leg	RP11-69E11.4	0.13	0.12	lasso	6	0.15	1.3e-12	-7.00	-7.7	1.5e-14	0.76	0.93	0.07	FALSE
40	GTEx	Stomach	RP11-69E11.4	0.31	0.20	lasso	4	0.20	4.0e-10	-6.95	-7.7	1.6e-14	0.58	0.73	0.26	FALSE
38	GTEx	Spleen	RP11-69E11.4	0.25	0.12	lasso	4	0.15	9.3e-05	-6.95	-7.6	2.2e-14	0.74	0.13	0.72	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	PABPC4	0.03	0.03	lasso	2	0.04	1.3e-08	-7.23	7.6	2.6e-14	-0.66	0.01	0.99	FALSE
8	GTEx	Adrenal Gland	PPIEL	0.29	0.01	lasso	3	0.00	2.9e-01	4.80	-7.6	3.7e-14	0.22	0.04	0.11	FALSE
32	GTEx	Nerve Tibial	RP11-69E11.8	0.05	0.00	lasso	3	0.01	6.9e-02	-7.23	7.5	5.0e-14	-0.78	0.04	0.84	FALSE
1	CommonMind	Brain Pre-frontal Cortex	BMP8A	0.05	0.03	lasso	3	0.02	8.8e-04	-7.24	-7.5	5.8e-14	0.76	0.03	0.94	FALSE
4	GTEx	Adipose Subcutaneous	BMP8A	0.06	0.05	lasso	1	0.04	3.5e-04	-7.29	-7.3	3.0e-13	0.50	0.14	0.26	FALSE
14	GTEx	Brain Frontal Cortex BA9	RP11-69E11.4	0.23	0.10	lasso	6	0.11	7.2e-04	-7.33	-7.3	3.0e-13	0.51	0.12	0.21	FALSE
18	GTEx	Cells Transformed fibroblasts	PABPC4	0.07	0.09	lasso	1	0.06	2.7e-05	-7.23	7.2	5.0e-13	-0.72	0.07	0.91	FALSE
22	GTEx	Esophagus Mucosa	RP11-69E11.4	0.18	0.06	lasso	9	0.07	2.2e-05	-6.95	-7.2	6.6e-13	0.68	0.58	0.41	FALSE
29	GTEx	Lung	RP11-69E11.4	0.26	0.09	lasso	9	0.20	3.8e-15	3.16	-7.2	9.0e-13	0.52	0.86	0.14	FALSE
23	GTEx	Esophagus Mucosa	BMP8A	0.08	0.02	lasso	2	0.01	1.4e-01	3.16	-7.1	1.2e-12	0.75	0.03	0.94	FALSE
21	GTEx	Esophagus Mucosa	PABPC4	0.06	0.06	lasso	3	0.08	7.3e-06	-7.24	7.1	1.3e-12	-0.78	0.16	0.81	FALSE
59	The Cancer Genome Atlas	Lung Adenocarcinoma	PABPC4	0.04	0.03	enet	8	0.04	4.5e-05	-7.24	7.1	1.6e-12	-0.68	0.00	0.99	FALSE
24	GTEx	Esophagus Mucosa	PPIEL	0.11	0.02	lasso	3	0.02	9.4e-03	-6.88	-7.0	1.8e-12	0.79	0.07	0.78	FALSE
35	GTEx	Skin Not Sun Exposed Suprapubic	PABPC4	0.12	0.10	lasso	3	0.05	1.0e-03	-7.24	7.0	1.9e-12	-0.75	0.20	0.59	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	BMP8A	0.05	0.01	lasso	6	0.02	5.5e-05	-7.24	-6.9	3.9e-12	0.60	0.48	0.18	FALSE
11	GTEx	Artery Tibial	PABPC4	0.10	0.10	lasso	4	0.10	3.4e-08	-7.23	6.9	6.3e-12	-0.76	0.51	0.49	FALSE
36	GTEx	Skin Sun Exposed Lower leg	PABPC4	0.11	0.09	lasso	7	0.08	2.7e-07	-7.24	6.8	1.1e-11	-0.76	0.15	0.85	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PABPC4	0.03	0.01	enet	4	0.02	4.3e-03	-7.23	6.8	1.2e-11	-0.73	0.00	0.97	FALSE
28	GTEx	Lung	PABPC4	0.05	0.03	lasso	3	0.02	1.3e-02	-7.23	6.7	2.8e-11	-0.69	0.20	0.53	FALSE
39	GTEx	Spleen	BMP8A	0.16	0.08	lasso	3	0.05	1.6e-02	-7.00	-6.6	3.6e-11	0.78	0.06	0.38	FALSE
15	GTEx	Breast Mammary Tissue	PABPC4	0.13	0.02	enet	14	0.04	3.4e-03	-7.24	6.6	3.8e-11	-0.75	0.05	0.88	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPIEL	0.04	0.02	lasso	4	0.02	1.7e-03	-6.95	-6.6	4.1e-11	0.59	0.02	0.78	FALSE
51	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PPIEL	0.06	0.08	lasso	1	0.05	1.4e-03	-6.57	-6.6	5.1e-11	0.46	0.01	0.91	FALSE
31	GTEx	Nerve Tibial	RP11-69E11.4	0.18	0.08	lasso	5	0.18	1.3e-12	-6.57	-6.4	1.2e-10	0.70	0.27	0.73	FALSE
43	GTEx	Thyroid	RP11-69E11.4	0.17	0.04	lasso	9	0.06	4.4e-05	-6.95	-6.4	1.2e-10	0.60	0.14	0.74	FALSE
10	GTEx	Artery Coronary	RP11-69E11.4	0.63	-0.01	lasso	9	0.10	2.2e-04	-7.33	-6.4	1.3e-10	0.58	0.12	0.20	FALSE
30	GTEx	Nerve Tibial	PABPC4	0.17	0.08	enet	12	0.05	2.7e-04	-7.23	6.4	1.3e-10	-0.75	0.14	0.85	FALSE
42	GTEx	Thyroid	PABPC4	0.08	0.03	lasso	6	0.05	1.3e-04	-8.38	6.4	1.4e-10	-0.82	0.03	0.96	FALSE
3	GTEx	Adipose Subcutaneous	RP11-69E11.4	0.14	0.08	enet	22	0.10	1.4e-08	-7.23	-6.4	1.8e-10	0.64	0.98	0.02	FALSE
2	GTEx	Adipose Subcutaneous	PABPC4	0.15	0.04	lasso	8	0.04	3.3e-04	-2.82	6.3	3.9e-10	-0.84	0.02	0.98	FALSE
20	GTEx	Colon Transverse	RP11-69E11.4	0.23	0.12	lasso	4	0.15	1.8e-07	-7.24	-6.3	3.9e-10	0.72	0.13	0.87	FALSE
12	GTEx	Artery Tibial	RP11-69E11.4	0.15	0.16	lasso	6	0.16	8.3e-13	-6.95	-6.2	6.0e-10	0.59	1.00	0.00	FALSE
27	GTEx	Heart Left Ventricle	RP11-69E11.4	0.10	0.10	lasso	4	0.08	3.8e-05	-6.95	-6.1	9.6e-10	0.53	0.41	0.37	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-69E11.4	0.10	0.07	lasso	2	0.07	1.3e-04	-6.95	-6.1	1.3e-09	0.51	0.24	0.70	FALSE
13	GTEx	Brain Cerebellar Hemisphere	RP11-69E11.4	0.22	0.08	enet	16	0.08	4.5e-03	-6.95	-6.0	2.1e-09	0.67	0.16	0.61	FALSE
44	METSIM	Adipose	PABPC4	0.05	0.02	lasso	6	0.03	6.0e-05	-7.24	6.0	2.3e-09	-0.75	0.10	0.89	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PPIEL	0.03	0.03	lasso	4	0.02	5.1e-03	-7.33	-5.9	4.6e-09	0.53	0.01	0.98	FALSE
34	GTEx	Pancreas	RP11-69E11.4	0.19	-0.01	enet	16	0.01	1.3e-01	1.76	-5.8	7.4e-09	0.55	0.06	0.42	FALSE
9	GTEx	Artery Aorta	RP11-69E11.4	0.13	0.10	enet	14	0.14	2.5e-08	-7.24	-5.8	8.4e-09	0.69	0.53	0.46	FALSE
16	GTEx	Breast Mammary Tissue	RP11-69E11.4	0.15	0.05	enet	32	0.05	8.8e-04	-3.42	-5.6	2.3e-08	0.62	0.29	0.66	FALSE
19	GTEx	Cells Transformed fibroblasts	RP11-69E11.4	0.15	0.08	enet	17	0.11	9.9e-09	-2.75	-5.5	3.3e-08	0.54	0.95	0.05	FALSE
25	GTEx	Esophagus Muscularis	BMP8A	0.08	0.05	enet	10	0.05	3.5e-04	-2.99	-5.4	6.6e-08	0.73	0.13	0.83	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PABPC4	0.05	0.05	enet	4	0.05	5.5e-04	-7.24	5.4	7.9e-08	-0.70	0.01	0.91	FALSE
48	YFS	Blood	NDUFS5	0.39	0.26	lasso	16	0.37	2.2e-128	-4.98	-5.3	8.7e-08	0.06	1.00	0.00	FALSE
41	GTEx	Testis	RP11-69E11.4	0.40	0.02	enet	52	0.14	1.0e-06	1.76	-5.2	2.4e-07	0.43	0.10	0.63	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	NDUFS5	0.12	0.11	enet	9	0.13	3.7e-14	-4.98	-5.2	2.5e-07	0.06	0.00	0.99	FALSE
26	GTEx	Heart Atrial Appendage	RP11-69E11.4	0.20	0.16	lasso	5	0.15	3.1e-07	-7.33	-5.2	2.6e-07	0.50	0.94	0.02	FALSE