Best TWAS P=4.98e-11 · Best GWAS P=7.17e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | PPIP5K2 | 0.07 | 0.04 | enet | 22 | 0.05 | 1.4e-04 | -5.1 | 6.0 | 1.5e-09 | -0.75 | 0.09 | 0.91 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | PPIP5K2 | 0.11 | 0.10 | lasso | 5 | 0.04 | 2.7e-03 | -5.0 | 5.4 | 7.4e-08 | -0.69 | 0.46 | 0.34 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | PPIP5K2 | 0.09 | 0.01 | lasso | 7 | 0.00 | 2.9e-01 | -4.3 | 5.5 | 3.5e-08 | -0.68 | 0.17 | 0.24 | FALSE |
| 4 | GTEx | Colon Sigmoid | PPIP5K2 | 0.14 | 0.00 | enet | 17 | 0.04 | 1.9e-02 | -4.7 | 5.2 | 2.7e-07 | -0.59 | 0.40 | 0.28 | FALSE |
| 5 | GTEx | Esophagus Muscularis | PPIP5K2 | 0.05 | 0.02 | enet | 14 | 0.03 | 9.8e-03 | -4.7 | 5.2 | 2.5e-07 | -0.65 | 0.42 | 0.45 | FALSE |
| 6 | GTEx | Nerve Tibial | PAM | 0.06 | 0.04 | lasso | 3 | 0.05 | 3.1e-04 | 3.6 | 5.5 | 2.8e-08 | -0.79 | 0.02 | 0.96 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | PAM | 0.04 | 0.00 | lasso | 4 | 0.04 | 2.3e-04 | -5.4 | -5.3 | 1.0e-07 | 0.68 | 0.15 | 0.22 | FALSE |
| 8 | GTEx | Thyroid | PAM | 0.07 | 0.08 | lasso | 4 | 0.07 | 5.5e-06 | -6.5 | 6.6 | 5.0e-11 | -0.99 | 0.00 | 1.00 | TRUE |
| 9 | GTEx | Whole Blood | PAM | 0.20 | 0.28 | lasso | 9 | 0.27 | 1.0e-24 | -5.8 | -5.7 | 1.5e-08 | 0.84 | 0.31 | 0.69 | FALSE |
| 10 | METSIM | Adipose | PAM | 0.04 | 0.02 | lasso | 2 | 0.02 | 2.9e-04 | -5.8 | -5.6 | 2.6e-08 | 0.75 | 0.20 | 0.70 | FALSE |
| 11 | NTR | Blood | PAM | 0.26 | 0.29 | lasso | 1 | 0.29 | 2.6e-95 | -5.2 | -5.2 | 1.8e-07 | 0.79 | 0.89 | 0.11 | FALSE |
| 12 | YFS | Blood | GIN1 | 0.02 | 0.04 | lasso | 7 | 0.05 | 5.1e-17 | -4.5 | -5.7 | 1.3e-08 | 0.70 | 0.80 | 0.20 | FALSE |
| 13 | YFS | Blood | PAM | 0.64 | 0.68 | enet | 68 | 0.72 | 0.0e+00 | -5.2 | -5.5 | 4.4e-08 | 0.81 | 0.89 | 0.11 | FALSE |