TWAS
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Models
Genes
Traits
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Traits
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Impedance of leg (right)
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chr5:178,525,779-180,195,862
Best TWAS P=2.59e-11 · Best GWAS P=1.67e-10 conditioned to 0.000581
178.6M
178.8M
179M
179.2M
179.4M
179.6M
179.8M
180M
180.2M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Esophagus Mucosa
RNF130
0.11
0.00
lasso
8
0.00
7.3e-01
-2.2
6.7
2.6e-11
-0.52
0.04
0.82
TRUE
4
METSIM
Adipose
LTC4S
0.05
0.04
lasso
4
0.02
1.5e-04
-6.1
-6.1
9.2e-10
0.91
0.02
0.98
FALSE
1
GTEx
Colon Transverse
RNF130
0.16
0.00
enet
21
0.01
1.5e-01
-6.1
5.5
4.2e-08
-0.64
0.03
0.71
FALSE
3
GTEx
Muscle Skeletal
RNF130
0.12
0.03
lasso
5
0.07
3.3e-07
-2.1
5.1
3.0e-07
-0.45
0.48
0.51
FALSE