[Hub]/) : Traits : Impedance of leg (right) : ← →

chr6:33,662,667-36,158,878

Best TWAS P=4.34e-16 · Best GWAS P=2.16e-16 conditioned to 0.00171

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
60	YFS	Blood	SNRPC	0.02	0.03	lasso	5	0.02	3.0e-08	-8.1	8.1	4.3e-16	-0.12	0.01	0.99	TRUE
25	GTEx	Cells Transformed fibroblasts	RPS10	0.12	0.05	lasso	4	0.06	4.5e-05	-8.0	-7.9	3.1e-15	0.93	0.04	0.96	TRUE
57	ROSMAP	Brain Pre-frontal Cortex	TEAD3	0.07	0.03	bslmm	421	0.04	5.6e-06	-4.1	5.7	1.5e-08	-0.23	0.04	0.86	TRUE
45	GTEx	Spleen	UHRF1BP1	0.34	0.21	enet	36	0.17	4.5e-05	-7.0	-8.1	5.4e-16	0.32	0.19	0.71	FALSE
15	GTEx	Brain Cerebellar Hemisphere	UHRF1BP1	0.22	0.16	lasso	12	0.15	1.0e-04	-6.8	-7.6	2.8e-14	0.12	0.09	0.80	FALSE
32	GTEx	Esophagus Muscularis	NUDT3	0.12	0.00	lasso	7	0.02	3.2e-02	-8.2	7.6	3.7e-14	-0.85	0.03	0.80	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PACSIN1	0.07	0.01	lasso	6	0.02	1.1e-03	-6.4	-7.6	3.9e-14	0.37	0.32	0.04	FALSE
18	GTEx	Brain Frontal Cortex BA9	RPS10	0.21	0.08	lasso	3	0.06	8.6e-03	-6.1	-7.4	9.9e-14	0.75	0.07	0.49	FALSE
49	GTEx	Uterus	UHRF1BP1	0.20	0.03	lasso	4	0.07	1.8e-02	-6.8	-7.4	1.6e-13	0.17	0.08	0.26	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	UHRF1BP1	0.47	0.38	enet	22	0.43	7.3e-17	-8.1	-7.3	2.1e-13	0.08	0.04	0.96	FALSE
31	GTEx	Esophagus Muscularis	SNRPC	0.09	0.11	lasso	3	0.07	3.8e-05	-6.8	7.3	3.1e-13	-0.12	0.13	0.86	FALSE
12	GTEx	Artery Tibial	SNRPC	0.06	0.06	lasso	4	0.05	1.3e-04	-6.8	7.3	3.2e-13	-0.12	0.10	0.89	FALSE
61	YFS	Blood	UHRF1BP1	0.18	0.34	enet	36	0.34	2.5e-117	-6.9	-7.3	4.0e-13	0.16	0.99	0.01	FALSE
72	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	UHRF1BP1	0.12	0.09	blup	70	0.06	5.6e-04	-6.8	-7.1	9.9e-13	0.11	0.06	0.79	FALSE
8	GTEx	Artery Aorta	UHRF1BP1	0.35	0.32	lasso	10	0.30	7.7e-17	-6.8	-7.1	1.1e-12	0.15	0.94	0.06	FALSE
14	GTEx	Brain Caudate basal ganglia	SNRPC	0.19	0.15	lasso	3	0.06	7.7e-03	-6.8	7.1	1.2e-12	-0.11	0.37	0.20	FALSE
37	GTEx	Muscle Skeletal	SNRPC	0.03	0.02	lasso	3	0.02	8.3e-03	-6.8	7.1	1.2e-12	-0.13	0.18	0.54	FALSE
24	GTEx	Cells Transformed fibroblasts	UHRF1BP1	0.34	0.32	enet	44	0.31	2.4e-23	-6.8	-7.0	1.8e-12	0.12	0.99	0.01	FALSE
26	GTEx	Colon Transverse	UHRF1BP1	0.42	0.28	lasso	4	0.28	1.6e-13	-6.8	-7.0	2.4e-12	0.12	0.56	0.44	FALSE
35	GTEx	Lung	UHRF1BP1	0.17	0.20	enet	22	0.18	4.3e-14	-6.8	-7.0	2.9e-12	0.10	0.99	0.01	FALSE
29	GTEx	Esophagus Mucosa	SNRPC	0.12	0.10	lasso	2	0.08	4.8e-06	-7.0	7.0	3.3e-12	-0.11	0.74	0.25	FALSE
38	GTEx	Muscle Skeletal	C6orf106	0.08	0.06	lasso	4	0.06	7.1e-07	-5.8	7.0	3.6e-12	-0.19	0.70	0.28	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UHRF1BP1	0.18	0.28	lasso	5	0.27	1.0e-30	-6.9	-7.0	3.6e-12	0.12	0.98	0.02	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SNRPC	0.10	0.16	lasso	4	0.15	3.6e-18	-7.0	6.9	3.7e-12	-0.12	0.99	0.01	FALSE
28	GTEx	Esophagus Mucosa	UHRF1BP1	0.14	0.15	enet	28	0.17	1.3e-11	-7.0	-6.9	4.8e-12	0.12	0.89	0.11	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	UHRF1BP1	0.04	0.05	lasso	3	0.04	8.4e-09	-6.9	-6.9	6.1e-12	0.11	0.65	0.35	FALSE
4	GTEx	Adipose Subcutaneous	UHRF1BP1	0.30	0.35	enet	28	0.36	1.6e-30	-6.8	-6.9	6.2e-12	0.11	0.99	0.01	FALSE
40	GTEx	Nerve Tibial	SNRPC	0.12	0.10	lasso	4	0.08	1.5e-06	-6.8	6.9	6.6e-12	-0.11	0.32	0.68	FALSE
3	CommonMind	Brain Pre-frontal Cortex	UHRF1BP1	0.17	0.23	lasso	19	0.22	5.8e-27	-6.8	-6.8	7.4e-12	0.11	0.99	0.01	FALSE
19	GTEx	Brain Putamen basal ganglia	UHRF1BP1	0.20	0.17	lasso	2	0.16	1.5e-04	-6.8	-6.8	7.8e-12	0.13	0.19	0.29	FALSE
81	The Cancer Genome Atlas	Stomach Adenocarcinoma	UHRF1BP1	0.08	0.10	lasso	1	0.10	7.1e-08	-6.8	-6.8	7.8e-12	0.11	0.84	0.16	FALSE
62	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UHRF1BP1	0.03	0.04	lasso	3	0.04	1.7e-04	-6.8	-6.8	8.5e-12	0.11	0.09	0.74	FALSE
66	The Cancer Genome Atlas	Colon Adenocarcinoma	UHRF1BP1	0.08	0.11	lasso	12	0.10	2.3e-06	-6.8	-6.8	8.5e-12	0.11	0.43	0.56	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	SNRPC	0.15	0.27	lasso	4	0.27	4.0e-35	-6.8	6.8	8.7e-12	-0.11	1.00	0.00	FALSE
43	GTEx	Skin Sun Exposed Lower leg	SNRPC	0.03	0.04	lasso	2	0.03	1.9e-03	-6.8	6.8	9.0e-12	-0.11	0.26	0.55	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SNRPC	0.06	0.07	lasso	2	0.07	6.7e-08	-6.8	6.8	9.0e-12	-0.11	0.75	0.25	FALSE
83	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SNRPC	0.09	0.11	lasso	2	0.10	8.1e-04	-6.8	6.8	9.3e-12	-0.11	0.03	0.58	FALSE
21	GTEx	Breast Mammary Tissue (Male)	UHRF1BP1	0.19	0.16	enet	24	0.08	5.6e-03	-6.8	-6.8	9.9e-12	0.13	0.25	0.47	FALSE
6	GTEx	Adipose Visceral Omentum	UHRF1BP1	0.30	0.34	lasso	3	0.34	3.0e-18	-6.8	-6.8	1.0e-11	0.11	0.97	0.03	FALSE
10	GTEx	Artery Coronary	UHRF1BP1	0.33	0.36	lasso	2	0.35	1.6e-12	-6.8	-6.8	1.0e-11	0.11	0.83	0.17	FALSE
67	The Cancer Genome Atlas	Esophageal Carcinoma	UHRF1BP1	0.19	0.20	lasso	10	0.17	5.2e-06	-6.8	-6.8	1.1e-11	0.11	0.54	0.40	FALSE
39	GTEx	Nerve Tibial	UHRF1BP1	0.31	0.31	lasso	6	0.31	3.9e-22	-6.8	-6.8	1.2e-11	0.12	0.99	0.01	FALSE
65	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	UHRF1BP1	0.07	0.11	lasso	3	0.07	2.6e-04	-6.8	-6.8	1.4e-11	0.11	0.21	0.73	FALSE
48	GTEx	Thyroid	SNRPC	0.07	0.04	lasso	6	0.05	1.6e-04	-6.8	6.7	2.0e-11	-0.11	0.70	0.16	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	UHRF1BP1	0.10	0.20	lasso	5	0.19	1.6e-19	-6.9	-6.7	2.7e-11	0.11	0.98	0.02	FALSE
56	NTR	Blood	UHRF1BP1	0.03	0.05	enet	19	0.05	7.4e-15	-6.5	-6.6	3.5e-11	0.09	0.97	0.03	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	UHRF1BP1	0.16	0.27	lasso	10	0.28	2.7e-36	-6.5	-6.6	3.7e-11	0.11	1.00	0.00	FALSE
34	GTEx	Liver	UHRF1BP1	0.13	0.04	lasso	3	0.05	1.8e-02	-6.8	-6.6	3.8e-11	0.08	0.14	0.20	FALSE
76	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	UHRF1BP1	0.06	0.07	lasso	1	0.05	1.5e-04	-6.5	-6.5	5.8e-11	0.10	0.23	0.73	FALSE
11	GTEx	Artery Tibial	UHRF1BP1	0.31	0.43	lasso	11	0.43	4.0e-36	-6.8	-6.5	6.4e-11	0.10	0.99	0.01	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	C6orf106	0.04	0.05	lasso	4	0.03	8.1e-05	-6.4	-6.4	2.0e-10	0.13	0.96	0.03	FALSE
54	METSIM	Adipose	UHRF1BP1	0.16	0.31	enet	30	0.32	1.0e-49	-6.8	-6.4	2.1e-10	0.11	0.99	0.01	FALSE
77	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UHRF1BP1	0.20	0.23	lasso	16	0.25	8.3e-11	-6.8	-6.4	2.1e-10	0.12	0.95	0.05	FALSE
47	GTEx	Testis	RPS10	0.17	0.11	lasso	1	0.04	5.2e-03	-6.3	-6.3	2.5e-10	0.74	0.12	0.60	FALSE
44	GTEx	Small Intestine Terminal Ileum	UHRF1BP1	0.20	0.03	lasso	5	0.00	3.4e-01	-6.8	-6.3	2.9e-10	0.09	0.08	0.49	FALSE
46	GTEx	Stomach	UHRF1BP1	0.24	0.22	enet	20	0.23	2.2e-11	-6.2	-6.3	3.0e-10	0.17	0.94	0.06	FALSE
13	GTEx	Brain Caudate basal ganglia	UHRF1BP1	0.19	0.14	lasso	7	0.12	3.1e-04	-6.8	-6.3	3.9e-10	0.11	0.37	0.12	FALSE
30	GTEx	Esophagus Muscularis	UHRF1BP1	0.42	0.35	enet	48	0.33	1.0e-20	-6.8	-6.2	4.4e-10	0.18	0.99	0.01	FALSE
51	GTEx	Whole Blood	UHRF1BP1	0.14	0.14	lasso	7	0.14	2.9e-13	-6.8	-6.2	5.8e-10	0.13	0.99	0.01	FALSE
33	GTEx	Heart Left Ventricle	UHRF1BP1	0.23	0.12	lasso	7	0.22	1.2e-11	-6.8	-6.2	6.3e-10	0.06	0.33	0.67	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UHRF1BP1	0.04	0.06	blup	70	0.06	1.5e-07	-6.9	-6.2	7.6e-10	0.07	0.12	0.88	FALSE
50	GTEx	Vagina	UHRF1BP1	0.31	0.05	lasso	8	0.04	5.0e-02	-6.8	-6.1	9.8e-10	0.07	0.10	0.43	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	SNRPC	0.05	0.05	blup	31	0.05	2.9e-05	-6.8	6.1	1.2e-09	-0.13	0.76	0.15	FALSE
55	NTR	Blood	C6orf106	0.03	0.02	lasso	6	0.02	7.2e-07	-6.4	-6.0	1.5e-09	0.10	0.98	0.01	FALSE
36	GTEx	Muscle Skeletal	UHRF1BP1	0.34	0.34	enet	45	0.39	4.3e-40	-6.8	-6.0	1.6e-09	0.07	1.00	0.00	FALSE
42	GTEx	Skin Sun Exposed Lower leg	UHRF1BP1	0.19	0.13	enet	33	0.14	2.7e-11	-6.8	-6.0	1.6e-09	-0.03	0.51	0.49	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	UHRF1BP1	0.06	0.07	enet	20	0.08	6.4e-10	-6.8	-6.0	1.9e-09	0.11	0.98	0.02	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNRPC	0.01	0.01	blup	31	0.00	3.0e-02	-3.7	6.0	2.4e-09	-0.12	0.03	0.13	FALSE
20	GTEx	Breast Mammary Tissue	UHRF1BP1	0.34	0.28	enet	46	0.29	4.7e-15	-6.8	-5.9	2.8e-09	0.06	0.95	0.05	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	C6orf106	0.20	0.00	lasso	5	0.00	2.7e-01	-6.9	-5.9	2.8e-09	0.14	0.07	0.06	FALSE
7	GTEx	Adrenal Gland	UHRF1BP1	0.32	0.26	enet	33	0.33	1.3e-12	-6.8	-5.9	3.5e-09	0.02	0.20	0.80	FALSE
22	GTEx	Breast Mammary Tissue (Female)	UHRF1BP1	0.23	0.21	lasso	3	0.20	1.0e-06	-6.8	-5.9	3.8e-09	0.12	0.52	0.40	FALSE
5	GTEx	Adipose Subcutaneous	SNRPC	0.13	0.13	enet	21	0.13	1.2e-10	-6.8	5.8	5.5e-09	-0.03	0.99	0.01	FALSE
75	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C6orf106	0.14	0.07	enet	6	0.06	1.0e-04	-6.4	-5.8	5.7e-09	0.08	0.20	0.54	FALSE
16	GTEx	Brain Cerebellum	UHRF1BP1	0.14	0.09	enet	23	0.12	1.5e-04	-6.8	-5.7	9.2e-09	0.10	0.12	0.47	FALSE
9	GTEx	Artery Aorta	SNRPC	0.06	0.03	enet	14	0.02	1.8e-02	-8.1	5.7	9.9e-09	-0.10	0.06	0.77	FALSE
52	METSIM	Adipose	C6orf106	0.04	0.02	blup	381	0.02	7.7e-04	-4.3	-5.7	1.0e-08	0.11	0.28	0.36	FALSE
17	GTEx	Brain Frontal Cortex BA9	UHRF1BP1	0.18	0.00	lasso	10	0.02	7.3e-02	-8.2	-5.5	2.9e-08	0.15	0.07	0.45	FALSE
53	METSIM	Adipose	SNRPC	0.05	0.05	lasso	7	0.07	2.9e-11	-6.8	5.5	4.6e-08	-0.10	0.96	0.04	FALSE
78	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UHRF1BP1	0.13	0.09	enet	13	0.10	6.4e-05	-6.8	-5.4	5.3e-08	0.15	0.22	0.54	FALSE
80	The Cancer Genome Atlas	Soft Tissue Sarcoma	UHRF1BP1	0.08	0.09	blup	71	0.08	1.0e-05	-6.8	-5.4	6.6e-08	0.11	0.63	0.21	FALSE
41	GTEx	Pancreas	C6orf106	0.14	0.11	enet	11	0.13	2.8e-06	-5.7	-5.4	6.7e-08	0.13	0.86	0.01	FALSE
70	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UHRF1BP1	0.08	0.09	blup	71	0.10	2.0e-06	-6.9	-5.3	1.1e-07	0.14	0.57	0.41	FALSE