Best TWAS P=4.34e-16 · Best GWAS P=2.16e-16 conditioned to 0.00171
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PACSIN1 | 0.07 | 0.01 | lasso | 6 | 0.02 | 1.1e-03 | -6.4 | -7.6 | 3.9e-14 | 0.37 | 0.32 | 0.04 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SNRPC | 0.10 | 0.16 | lasso | 4 | 0.15 | 3.6e-18 | -7.0 | 6.9 | 3.7e-12 | -0.12 | 0.99 | 0.01 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | UHRF1BP1 | 0.17 | 0.23 | lasso | 19 | 0.22 | 5.8e-27 | -6.8 | -6.8 | 7.4e-12 | 0.11 | 0.99 | 0.01 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | UHRF1BP1 | 0.30 | 0.35 | enet | 28 | 0.36 | 1.6e-30 | -6.8 | -6.9 | 6.2e-12 | 0.11 | 0.99 | 0.01 | FALSE |
| 5 | GTEx | Adipose Subcutaneous | SNRPC | 0.13 | 0.13 | enet | 21 | 0.13 | 1.2e-10 | -6.8 | 5.8 | 5.5e-09 | -0.03 | 0.99 | 0.01 | FALSE |
| 6 | GTEx | Adipose Visceral Omentum | UHRF1BP1 | 0.30 | 0.34 | lasso | 3 | 0.34 | 3.0e-18 | -6.8 | -6.8 | 1.0e-11 | 0.11 | 0.97 | 0.03 | FALSE |
| 7 | GTEx | Adrenal Gland | UHRF1BP1 | 0.32 | 0.26 | enet | 33 | 0.33 | 1.3e-12 | -6.8 | -5.9 | 3.5e-09 | 0.02 | 0.20 | 0.80 | FALSE |
| 8 | GTEx | Artery Aorta | UHRF1BP1 | 0.35 | 0.32 | lasso | 10 | 0.30 | 7.7e-17 | -6.8 | -7.1 | 1.1e-12 | 0.15 | 0.94 | 0.06 | FALSE |
| 9 | GTEx | Artery Aorta | SNRPC | 0.06 | 0.03 | enet | 14 | 0.02 | 1.8e-02 | -8.1 | 5.7 | 9.9e-09 | -0.10 | 0.06 | 0.77 | FALSE |
| 10 | GTEx | Artery Coronary | UHRF1BP1 | 0.33 | 0.36 | lasso | 2 | 0.35 | 1.6e-12 | -6.8 | -6.8 | 1.0e-11 | 0.11 | 0.83 | 0.17 | FALSE |
| 11 | GTEx | Artery Tibial | UHRF1BP1 | 0.31 | 0.43 | lasso | 11 | 0.43 | 4.0e-36 | -6.8 | -6.5 | 6.4e-11 | 0.10 | 0.99 | 0.01 | FALSE |
| 12 | GTEx | Artery Tibial | SNRPC | 0.06 | 0.06 | lasso | 4 | 0.05 | 1.3e-04 | -6.8 | 7.3 | 3.2e-13 | -0.12 | 0.10 | 0.89 | FALSE |
| 13 | GTEx | Brain Caudate basal ganglia | UHRF1BP1 | 0.19 | 0.14 | lasso | 7 | 0.12 | 3.1e-04 | -6.8 | -6.3 | 3.9e-10 | 0.11 | 0.37 | 0.12 | FALSE |
| 14 | GTEx | Brain Caudate basal ganglia | SNRPC | 0.19 | 0.15 | lasso | 3 | 0.06 | 7.7e-03 | -6.8 | 7.1 | 1.2e-12 | -0.11 | 0.37 | 0.20 | FALSE |
| 15 | GTEx | Brain Cerebellar Hemisphere | UHRF1BP1 | 0.22 | 0.16 | lasso | 12 | 0.15 | 1.0e-04 | -6.8 | -7.6 | 2.8e-14 | 0.12 | 0.09 | 0.80 | FALSE |
| 16 | GTEx | Brain Cerebellum | UHRF1BP1 | 0.14 | 0.09 | enet | 23 | 0.12 | 1.5e-04 | -6.8 | -5.7 | 9.2e-09 | 0.10 | 0.12 | 0.47 | FALSE |
| 17 | GTEx | Brain Frontal Cortex BA9 | UHRF1BP1 | 0.18 | 0.00 | lasso | 10 | 0.02 | 7.3e-02 | -8.2 | -5.5 | 2.9e-08 | 0.15 | 0.07 | 0.45 | FALSE |
| 18 | GTEx | Brain Frontal Cortex BA9 | RPS10 | 0.21 | 0.08 | lasso | 3 | 0.06 | 8.6e-03 | -6.1 | -7.4 | 9.9e-14 | 0.75 | 0.07 | 0.49 | FALSE |
| 19 | GTEx | Brain Putamen basal ganglia | UHRF1BP1 | 0.20 | 0.17 | lasso | 2 | 0.16 | 1.5e-04 | -6.8 | -6.8 | 7.8e-12 | 0.13 | 0.19 | 0.29 | FALSE |
| 20 | GTEx | Breast Mammary Tissue | UHRF1BP1 | 0.34 | 0.28 | enet | 46 | 0.29 | 4.7e-15 | -6.8 | -5.9 | 2.8e-09 | 0.06 | 0.95 | 0.05 | FALSE |
| 21 | GTEx | Breast Mammary Tissue (Male) | UHRF1BP1 | 0.19 | 0.16 | enet | 24 | 0.08 | 5.6e-03 | -6.8 | -6.8 | 9.9e-12 | 0.13 | 0.25 | 0.47 | FALSE |
| 22 | GTEx | Breast Mammary Tissue (Female) | UHRF1BP1 | 0.23 | 0.21 | lasso | 3 | 0.20 | 1.0e-06 | -6.8 | -5.9 | 3.8e-09 | 0.12 | 0.52 | 0.40 | FALSE |
| 23 | GTEx | Cells EBV-transformed lymphocytes | C6orf106 | 0.20 | 0.00 | lasso | 5 | 0.00 | 2.7e-01 | -6.9 | -5.9 | 2.8e-09 | 0.14 | 0.07 | 0.06 | FALSE |
| 24 | GTEx | Cells Transformed fibroblasts | UHRF1BP1 | 0.34 | 0.32 | enet | 44 | 0.31 | 2.4e-23 | -6.8 | -7.0 | 1.8e-12 | 0.12 | 0.99 | 0.01 | FALSE |
| 25 | GTEx | Cells Transformed fibroblasts | RPS10 | 0.12 | 0.05 | lasso | 4 | 0.06 | 4.5e-05 | -8.0 | -7.9 | 3.1e-15 | 0.93 | 0.04 | 0.96 | TRUE |
| 26 | GTEx | Colon Transverse | UHRF1BP1 | 0.42 | 0.28 | lasso | 4 | 0.28 | 1.6e-13 | -6.8 | -7.0 | 2.4e-12 | 0.12 | 0.56 | 0.44 | FALSE |
| 27 | GTEx | Esophagus Gastroesophageal Junction | UHRF1BP1 | 0.47 | 0.38 | enet | 22 | 0.43 | 7.3e-17 | -8.1 | -7.3 | 2.1e-13 | 0.08 | 0.04 | 0.96 | FALSE |
| 28 | GTEx | Esophagus Mucosa | UHRF1BP1 | 0.14 | 0.15 | enet | 28 | 0.17 | 1.3e-11 | -7.0 | -6.9 | 4.8e-12 | 0.12 | 0.89 | 0.11 | FALSE |
| 29 | GTEx | Esophagus Mucosa | SNRPC | 0.12 | 0.10 | lasso | 2 | 0.08 | 4.8e-06 | -7.0 | 7.0 | 3.3e-12 | -0.11 | 0.74 | 0.25 | FALSE |
| 30 | GTEx | Esophagus Muscularis | UHRF1BP1 | 0.42 | 0.35 | enet | 48 | 0.33 | 1.0e-20 | -6.8 | -6.2 | 4.4e-10 | 0.18 | 0.99 | 0.01 | FALSE |
| 31 | GTEx | Esophagus Muscularis | SNRPC | 0.09 | 0.11 | lasso | 3 | 0.07 | 3.8e-05 | -6.8 | 7.3 | 3.1e-13 | -0.12 | 0.13 | 0.86 | FALSE |
| 32 | GTEx | Esophagus Muscularis | NUDT3 | 0.12 | 0.00 | lasso | 7 | 0.02 | 3.2e-02 | -8.2 | 7.6 | 3.7e-14 | -0.85 | 0.03 | 0.80 | FALSE |
| 33 | GTEx | Heart Left Ventricle | UHRF1BP1 | 0.23 | 0.12 | lasso | 7 | 0.22 | 1.2e-11 | -6.8 | -6.2 | 6.3e-10 | 0.06 | 0.33 | 0.67 | FALSE |
| 34 | GTEx | Liver | UHRF1BP1 | 0.13 | 0.04 | lasso | 3 | 0.05 | 1.8e-02 | -6.8 | -6.6 | 3.8e-11 | 0.08 | 0.14 | 0.20 | FALSE |
| 35 | GTEx | Lung | UHRF1BP1 | 0.17 | 0.20 | enet | 22 | 0.18 | 4.3e-14 | -6.8 | -7.0 | 2.9e-12 | 0.10 | 0.99 | 0.01 | FALSE |
| 36 | GTEx | Muscle Skeletal | UHRF1BP1 | 0.34 | 0.34 | enet | 45 | 0.39 | 4.3e-40 | -6.8 | -6.0 | 1.6e-09 | 0.07 | 1.00 | 0.00 | FALSE |
| 37 | GTEx | Muscle Skeletal | SNRPC | 0.03 | 0.02 | lasso | 3 | 0.02 | 8.3e-03 | -6.8 | 7.1 | 1.2e-12 | -0.13 | 0.18 | 0.54 | FALSE |
| 38 | GTEx | Muscle Skeletal | C6orf106 | 0.08 | 0.06 | lasso | 4 | 0.06 | 7.1e-07 | -5.8 | 7.0 | 3.6e-12 | -0.19 | 0.70 | 0.28 | FALSE |
| 39 | GTEx | Nerve Tibial | UHRF1BP1 | 0.31 | 0.31 | lasso | 6 | 0.31 | 3.9e-22 | -6.8 | -6.8 | 1.2e-11 | 0.12 | 0.99 | 0.01 | FALSE |
| 40 | GTEx | Nerve Tibial | SNRPC | 0.12 | 0.10 | lasso | 4 | 0.08 | 1.5e-06 | -6.8 | 6.9 | 6.6e-12 | -0.11 | 0.32 | 0.68 | FALSE |
| 41 | GTEx | Pancreas | C6orf106 | 0.14 | 0.11 | enet | 11 | 0.13 | 2.8e-06 | -5.7 | -5.4 | 6.7e-08 | 0.13 | 0.86 | 0.01 | FALSE |
| 42 | GTEx | Skin Sun Exposed Lower leg | UHRF1BP1 | 0.19 | 0.13 | enet | 33 | 0.14 | 2.7e-11 | -6.8 | -6.0 | 1.6e-09 | -0.03 | 0.51 | 0.49 | FALSE |
| 43 | GTEx | Skin Sun Exposed Lower leg | SNRPC | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.9e-03 | -6.8 | 6.8 | 9.0e-12 | -0.11 | 0.26 | 0.55 | FALSE |
| 44 | GTEx | Small Intestine Terminal Ileum | UHRF1BP1 | 0.20 | 0.03 | lasso | 5 | 0.00 | 3.4e-01 | -6.8 | -6.3 | 2.9e-10 | 0.09 | 0.08 | 0.49 | FALSE |
| 45 | GTEx | Spleen | UHRF1BP1 | 0.34 | 0.21 | enet | 36 | 0.17 | 4.5e-05 | -7.0 | -8.1 | 5.4e-16 | 0.32 | 0.19 | 0.71 | FALSE |
| 46 | GTEx | Stomach | UHRF1BP1 | 0.24 | 0.22 | enet | 20 | 0.23 | 2.2e-11 | -6.2 | -6.3 | 3.0e-10 | 0.17 | 0.94 | 0.06 | FALSE |
| 47 | GTEx | Testis | RPS10 | 0.17 | 0.11 | lasso | 1 | 0.04 | 5.2e-03 | -6.3 | -6.3 | 2.5e-10 | 0.74 | 0.12 | 0.60 | FALSE |
| 48 | GTEx | Thyroid | SNRPC | 0.07 | 0.04 | lasso | 6 | 0.05 | 1.6e-04 | -6.8 | 6.7 | 2.0e-11 | -0.11 | 0.70 | 0.16 | FALSE |
| 49 | GTEx | Uterus | UHRF1BP1 | 0.20 | 0.03 | lasso | 4 | 0.07 | 1.8e-02 | -6.8 | -7.4 | 1.6e-13 | 0.17 | 0.08 | 0.26 | FALSE |
| 50 | GTEx | Vagina | UHRF1BP1 | 0.31 | 0.05 | lasso | 8 | 0.04 | 5.0e-02 | -6.8 | -6.1 | 9.8e-10 | 0.07 | 0.10 | 0.43 | FALSE |
| 51 | GTEx | Whole Blood | UHRF1BP1 | 0.14 | 0.14 | lasso | 7 | 0.14 | 2.9e-13 | -6.8 | -6.2 | 5.8e-10 | 0.13 | 0.99 | 0.01 | FALSE |
| 52 | METSIM | Adipose | C6orf106 | 0.04 | 0.02 | blup | 381 | 0.02 | 7.7e-04 | -4.3 | -5.7 | 1.0e-08 | 0.11 | 0.28 | 0.36 | FALSE |
| 53 | METSIM | Adipose | SNRPC | 0.05 | 0.05 | lasso | 7 | 0.07 | 2.9e-11 | -6.8 | 5.5 | 4.6e-08 | -0.10 | 0.96 | 0.04 | FALSE |
| 54 | METSIM | Adipose | UHRF1BP1 | 0.16 | 0.31 | enet | 30 | 0.32 | 1.0e-49 | -6.8 | -6.4 | 2.1e-10 | 0.11 | 0.99 | 0.01 | FALSE |
| 55 | NTR | Blood | C6orf106 | 0.03 | 0.02 | lasso | 6 | 0.02 | 7.2e-07 | -6.4 | -6.0 | 1.5e-09 | 0.10 | 0.98 | 0.01 | FALSE |
| 56 | NTR | Blood | UHRF1BP1 | 0.03 | 0.05 | enet | 19 | 0.05 | 7.4e-15 | -6.5 | -6.6 | 3.5e-11 | 0.09 | 0.97 | 0.03 | FALSE |
| 57 | ROSMAP | Brain Pre-frontal Cortex | TEAD3 | 0.07 | 0.03 | bslmm | 421 | 0.04 | 5.6e-06 | -4.1 | 5.7 | 1.5e-08 | -0.23 | 0.04 | 0.86 | TRUE |
| 58 | ROSMAP | Brain Pre-frontal Cortex | UHRF1BP1 | 0.16 | 0.27 | lasso | 10 | 0.28 | 2.7e-36 | -6.5 | -6.6 | 3.7e-11 | 0.11 | 1.00 | 0.00 | FALSE |
| 59 | ROSMAP | Brain Pre-frontal Cortex | SNRPC | 0.15 | 0.27 | lasso | 4 | 0.27 | 4.0e-35 | -6.8 | 6.8 | 8.7e-12 | -0.11 | 1.00 | 0.00 | FALSE |
| 60 | YFS | Blood | SNRPC | 0.02 | 0.03 | lasso | 5 | 0.02 | 3.0e-08 | -8.1 | 8.1 | 4.3e-16 | -0.12 | 0.01 | 0.99 | TRUE |
| 61 | YFS | Blood | UHRF1BP1 | 0.18 | 0.34 | enet | 36 | 0.34 | 2.5e-117 | -6.9 | -7.3 | 4.0e-13 | 0.16 | 0.99 | 0.01 | FALSE |
| 62 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | UHRF1BP1 | 0.03 | 0.04 | lasso | 3 | 0.04 | 1.7e-04 | -6.8 | -6.8 | 8.5e-12 | 0.11 | 0.09 | 0.74 | FALSE |
| 63 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNRPC | 0.01 | 0.01 | blup | 31 | 0.00 | 3.0e-02 | -3.7 | 6.0 | 2.4e-09 | -0.12 | 0.03 | 0.13 | FALSE |
| 64 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UHRF1BP1 | 0.04 | 0.05 | lasso | 3 | 0.04 | 8.4e-09 | -6.9 | -6.9 | 6.1e-12 | 0.11 | 0.65 | 0.35 | FALSE |
| 65 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | UHRF1BP1 | 0.07 | 0.11 | lasso | 3 | 0.07 | 2.6e-04 | -6.8 | -6.8 | 1.4e-11 | 0.11 | 0.21 | 0.73 | FALSE |
| 66 | The Cancer Genome Atlas | Colon Adenocarcinoma | UHRF1BP1 | 0.08 | 0.11 | lasso | 12 | 0.10 | 2.3e-06 | -6.8 | -6.8 | 8.5e-12 | 0.11 | 0.43 | 0.56 | FALSE |
| 67 | The Cancer Genome Atlas | Esophageal Carcinoma | UHRF1BP1 | 0.19 | 0.20 | lasso | 10 | 0.17 | 5.2e-06 | -6.8 | -6.8 | 1.1e-11 | 0.11 | 0.54 | 0.40 | FALSE |
| 68 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SNRPC | 0.06 | 0.07 | lasso | 2 | 0.07 | 6.7e-08 | -6.8 | 6.8 | 9.0e-12 | -0.11 | 0.75 | 0.25 | FALSE |
| 69 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | UHRF1BP1 | 0.18 | 0.28 | lasso | 5 | 0.27 | 1.0e-30 | -6.9 | -7.0 | 3.6e-12 | 0.12 | 0.98 | 0.02 | FALSE |
| 70 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | UHRF1BP1 | 0.08 | 0.09 | blup | 71 | 0.10 | 2.0e-06 | -6.9 | -5.3 | 1.1e-07 | 0.14 | 0.57 | 0.41 | FALSE |
| 71 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf106 | 0.04 | 0.05 | lasso | 4 | 0.03 | 8.1e-05 | -6.4 | -6.4 | 2.0e-10 | 0.13 | 0.96 | 0.03 | FALSE |
| 72 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | UHRF1BP1 | 0.12 | 0.09 | blup | 70 | 0.06 | 5.6e-04 | -6.8 | -7.1 | 9.9e-13 | 0.11 | 0.06 | 0.79 | FALSE |
| 73 | The Cancer Genome Atlas | Lung Adenocarcinoma | UHRF1BP1 | 0.06 | 0.07 | enet | 20 | 0.08 | 6.4e-10 | -6.8 | -6.0 | 1.9e-09 | 0.11 | 0.98 | 0.02 | FALSE |
| 74 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | UHRF1BP1 | 0.04 | 0.06 | blup | 70 | 0.06 | 1.5e-07 | -6.9 | -6.2 | 7.6e-10 | 0.07 | 0.12 | 0.88 | FALSE |
| 75 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf106 | 0.14 | 0.07 | enet | 6 | 0.06 | 1.0e-04 | -6.4 | -5.8 | 5.7e-09 | 0.08 | 0.20 | 0.54 | FALSE |
| 76 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | UHRF1BP1 | 0.06 | 0.07 | lasso | 1 | 0.05 | 1.5e-04 | -6.5 | -6.5 | 5.8e-11 | 0.10 | 0.23 | 0.73 | FALSE |
| 77 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | UHRF1BP1 | 0.20 | 0.23 | lasso | 16 | 0.25 | 8.3e-11 | -6.8 | -6.4 | 2.1e-10 | 0.12 | 0.95 | 0.05 | FALSE |
| 78 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | UHRF1BP1 | 0.13 | 0.09 | enet | 13 | 0.10 | 6.4e-05 | -6.8 | -5.4 | 5.3e-08 | 0.15 | 0.22 | 0.54 | FALSE |
| 79 | The Cancer Genome Atlas | Prostate Adenocarcinoma | UHRF1BP1 | 0.10 | 0.20 | lasso | 5 | 0.19 | 1.6e-19 | -6.9 | -6.7 | 2.7e-11 | 0.11 | 0.98 | 0.02 | FALSE |
| 80 | The Cancer Genome Atlas | Soft Tissue Sarcoma | UHRF1BP1 | 0.08 | 0.09 | blup | 71 | 0.08 | 1.0e-05 | -6.8 | -5.4 | 6.6e-08 | 0.11 | 0.63 | 0.21 | FALSE |
| 81 | The Cancer Genome Atlas | Stomach Adenocarcinoma | UHRF1BP1 | 0.08 | 0.10 | lasso | 1 | 0.10 | 7.1e-08 | -6.8 | -6.8 | 7.8e-12 | 0.11 | 0.84 | 0.16 | FALSE |
| 82 | The Cancer Genome Atlas | Thyroid Carcinoma | SNRPC | 0.05 | 0.05 | blup | 31 | 0.05 | 2.9e-05 | -6.8 | 6.1 | 1.2e-09 | -0.13 | 0.76 | 0.15 | FALSE |
| 83 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | SNRPC | 0.09 | 0.11 | lasso | 2 | 0.10 | 8.1e-04 | -6.8 | 6.8 | 9.3e-12 | -0.11 | 0.03 | 0.58 | FALSE |