TWAS hub - RNF130

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0948	0.0338	8.7e-04	0.014	NA	0.038	NA	0.035	2.8e-02	NA	5.9e-04	NA	8.4e-04
2	GTEx	Cells Transformed fibroblasts	0.2270	0.0410	4.2e-14	0.194	NA	0.229	NA	0.196	1.6e-14	NA	4.2e-17	NA	1.2e-14
3	GTEx	Colon Transverse	0.1620	0.0710	6.0e-03	-0.005	NA	0.007	NA	-0.004	6.2e-01	NA	1.5e-01	NA	5.5e-01
4	GTEx	Esophagus Mucosa	0.1060	0.0380	1.8e-03	0.001	NA	-0.004	NA	-0.004	2.7e-01	NA	9.3e-01	NA	7.3e-01
5	GTEx	Lung	0.1004	0.0397	6.5e-03	0.002	NA	0.006	NA	0.011	2.2e-01	NA	1.0e-01	NA	4.8e-02
6	GTEx	Muscle Skeletal	0.1154	0.0309	1.5e-06	0.034	NA	0.051	NA	0.068	2.4e-04	NA	9.1e-06	NA	3.3e-07
7	GTEx	Pancreas	0.2210	0.0750	1.9e-03	0.134	NA	0.122	NA	0.138	2.8e-06	NA	8.0e-06	NA	2.0e-06
8	GTEx	Skin Sun Exposed Lower leg	0.1140	0.0450	2.4e-03	0.020	NA	0.033	NA	0.052	7.9e-03	NA	8.4e-04	NA	3.9e-05
9	GTEx	Thyroid	0.1500	0.0420	2.0e-06	0.045	NA	0.053	NA	0.057	2.2e-04	NA	6.9e-05	NA	3.5e-05
10	GTEx	Whole Blood	0.1510	0.0470	2.7e-04	0.079	NA	0.042	NA	0.051	8.6e-08	NA	9.6e-05	NA	1.6e-05
11	METSIM	Adipose	0.0528	0.0204	6.3e-04	0.030	0.023	0.023	0.022	0.023	2.0e-05	0.0002	1.9e-04	0.00023	1.6e-04
12	ROSMAP	Brain Pre-frontal Cortex	0.0538	0.0220	3.7e-03	0.009	0.008	0.000	0.013	0.006	2.1e-02	0.0270	3.0e-01	0.00780	5.3e-02
13	TCGA	Breast Invasive Carcinoma	0.0239	0.0125	8.5e-03	-0.001	0.002	-0.001	NA	-0.001	8.3e-01	0.1300	6.0e-01	NA	7.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Suffer from ‘nerves’	5.6	8.8	21.4	2.7	4.2	3.6	4.6	2.1	3.8	0.6	2.1	3.3	-0.3	3.7	2.0	1.2
Lung cancer (father)	4.0	4.7	8.5	2.4	2.6	2.6	2.5	0.4	2.9	1.5	1.5	2.8	2.1	2.6	1.3	1.4
Neuroticism	3.9	9.4	21.8	3.5	4.7	2.5	4.6	1.2	4.2	0.4	2.0	3.6	-1.0	4.3	1.8	0.9
Reason for reducing amount of alcohol drunk: Health precaution	3.9	4.5	9.5	1.4	2.7	2.2	2.1	2.7	2.6	1.8	-0.5	3.0	-0.6	3.1	1.8	0.4
Neuroticism (Nagel 2018)	3.7	8.6	21.2	3.1	4.3	2.5	4.6	2.0	3.9	-0.7	0.7	3.4	-1.9	4.1	1.9	-0.3
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	9.9	2.6	2.9	2.1	2.1	0.5	3.1	1.6	2.5	2.7	0.3	2.8	1.6	1.1
Supplements: Calcium	3.7	4.1	10.9	3.3	2.7	0.5	2.0	1.6	2.5	0.5	2.5	2.6	1.2	2.6	0.9	-0.1
Neuroticism score	3.6	7.6	18.2	2.8	4.3	2.3	4.2	1.1	3.7	0.2	2.2	3.0	-1.4	3.6	2.3	0.2
Ulcerative Colitis	3.5	5.1	10.6	3.2	3.2	1.7	2.2	0.3	3.0	1.1	2.4	3.1	0.2	2.6	2.1	0.8
Exposure to tobacco smoke at home	3.5	3.9	9.3	2.3	2.3	0.6	0.8	0.8	2.7	2.2	3.0	2.9	-1.1	2.5	-0.4	0.7
Worry (Nagel 2018)	3.4	7.2	18.3	2.3	4.2	2.3	4.3	1.3	3.8	-0.0	0.9	3.3	-1.4	3.7	1.9	0.5
Medication: Lansoprazole	3.2	3.6	8.1	2.8	2.5	0.9	2.9	1.2	2.0	-2.0	1.9	1.4	-2.0	1.4	0.5	-1.8
Depressed Affect (Nagel 2018)	3.1	6.5	13.2	3.0	3.6	2.1	3.6	2.1	3.6	-1.0	1.3	2.6	-1.4	3.6	1.2	-0.9
Systolic Blood Pressure	3.1	15.4	35.4	4.7	5.2	3.8	6.0	2.1	4.9	0.2	4.4	3.6	1.0	3.7	3.3	4.0
Impedance of leg (right)	3.0	14.7	44.5	3.3	4.3	5.5	6.7	1.1	5.1	1.1	3.3	2.6	-0.3	2.3	5.0	3.2
Birth weight of first child	3.0	5.4	11.8	-2.1	-2.9	-2.6	-3.4	0.0	-2.8	-1.3	-2.8	-1.9	-0.4	-2.9	-1.7	-2.7
High blood pressure (siblings)	3.0	4.3	10.6	3.3	2.8	1.3	2.5	0.5	3.1	0.8	3.1	2.3	0.0	1.5	-0.1	1.3
Health satisfaction	3.0	4.0	9.1	2.7	3.0	0.8	2.6	1.0	2.8	-0.6	0.6	2.7	-1.6	2.5	0.2	-1.2
Medication: Ibuprofen	2.9	3.5	6.7	2.5	2.6	1.4	1.7	0.6	2.6	1.1	2.1	2.5	0.6	2.5	1.5	0.6
Current tobacco smoking	2.8	4.5	13.1	3.1	2.3	0.2	1.4	1.5	2.5	2.3	3.6	2.5	1.2	2.1	1.1	1.4
Neck or shoulder pain in last month	2.6	3.7	8.8	3.0	2.1	0.6	2.7	1.9	1.6	-2.0	2.3	1.0	-1.2	0.9	2.6	-1.4
Medication: Seretide 50 evohaler	2.6	3.0	9.8	-1.1	-1.5	-1.3	-1.2	-0.4	-2.1	-2.2	-1.2	-1.5	-2.6	-1.5	-0.4	-3.1
Pain type(s) experienced in last month: Hip pain	2.6	3.3	8.0	1.7	2.5	1.8	2.1	0.2	2.5	0.8	2.2	1.3	0.4	2.8	1.7	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.8	12.1	1.8	3.1	1.1	3.5	-0.4	2.4	-0.7	0.8	2.5	0.2	2.8	0.8	1.0
Mood swings	2.5	4.5	9.9	2.9	2.9	1.2	3.2	1.4	2.3	-1.6	1.9	2.0	-1.4	2.8	0.9	-1.6
Systolic blood pressure, automated reading	2.4	6.8	11.3	3.0	3.0	3.0	3.3	2.2	2.7	0.6	3.4	2.1	0.7	2.0	3.3	2.7
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	6.4	0.2	-0.8	-2.5	-2.1	-0.9	-1.8	-2.1	-0.0	-0.8	-2.4	-0.3	-1.2	-2.1
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	4.9	-1.3	-1.9	-1.1	-1.4	-1.2	-1.9	-1.9	-1.4	-2.2	-0.7	-2.0	-1.0	-1.7
Nervous feelings	2.3	4.4	14.0	1.9	3.0	1.7	3.7	1.4	2.4	-0.3	0.5	2.4	-0.9	2.6	2.3	0.7
Smoking status: Current	2.3	3.6	12.5	3.1	2.0	-0.2	1.0	0.9	2.2	2.0	3.5	2.2	1.0	1.7	0.7	1.0
Hearing difficulty/problems with background noise	2.2	3.6	10.4	2.3	2.4	0.4	1.6	2.0	2.4	0.2	1.0	3.2	-1.2	2.7	1.3	-1.0
Multivitamins +/- minerals	2.1	2.6	8.0	1.6	1.4	1.0	2.4	0.8	1.4	-0.3	0.2	1.1	2.7	0.9	2.8	1.7
Mouth/teeth dental problems: Loose teeth	2.1	2.4	5.3	-1.8	-1.7	-2.3	-2.3	-0.2	-2.1	-0.1	-2.0	-2.2	0.4	-0.9	-1.0	0.2
Pain experienced in last month	2.1	3.4	8.0	-2.5	-2.4	-0.6	-1.7	-1.5	-2.3	-0.4	-2.8	-1.9	1.0	-2.5	-1.5	0.9
Sensitivity / hurt feelings	2.0	3.4	10.5	1.4	2.4	2.5	3.2	1.1	2.2	0.2	0.3	1.4	-0.7	2.2	1.7	1.6
Illnesses of father: High blood pressure	2.0	2.4	4.2	2.1	1.7	1.8	1.3	1.6	1.9	-0.0	1.6	1.2	0.5	1.4	1.8	1.9
High blood pressure	1.9	5.2	14.1	3.8	3.5	1.5	2.8	1.2	2.7	-1.0	2.5	2.5	-0.1	2.8	1.2	0.8
Impedance of leg (left)	1.8	8.9	28.5	2.2	3.2	4.1	5.3	1.2	4.0	0.9	2.2	1.8	-0.4	1.8	4.3	2.3
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	7.7	-1.1	-1.6	-1.7	-2.4	0.0	-2.1	-0.9	-1.5	-1.4	0.3	-1.0	-2.8	-0.5
Hypertension (Self-reported)	1.8	5.0	12.8	3.6	3.3	1.7	2.8	1.1	2.4	-0.9	2.5	2.2	-0.8	2.5	1.8	0.8
Number of self-reported non-cancer illnesses	1.8	3.1	8.4	2.5	2.5	0.8	1.1	1.5	2.3	-0.5	1.6	2.2	-0.4	2.9	-1.3	-0.2
Financial situation satisfaction	1.8	2.2	6.5	2.5	2.3	0.7	2.1	0.2	2.1	-0.2	1.4	1.6	0.2	1.6	0.7	0.3
Basal cell carcinoma (self-reported)	1.8	2.2	6.1	-1.1	-1.1	-2.5	-0.2	-0.5	-1.4	-2.2	-1.6	-1.3	-1.3	-1.1	-0.2	-2.3
Pack years of smoking	1.8	2.6	8.9	-1.8	-1.9	-2.5	-3.0	0.2	-2.0	1.1	-0.5	-1.9	1.6	-0.5	0.3	0.3
Ulcerative Colitis (UC)	1.7	3.2	9.7	2.9	2.3	1.1	1.8	0.5	1.7	0.1	3.1	1.8	-1.6	1.0	2.0	0.0
Tense / ‘highly strung’	1.7	2.7	10.9	1.6	2.2	1.1	3.3	1.0	2.2	-0.6	0.5	1.4	-0.8	1.8	1.9	-0.4
Heart disease (mother)	1.7	2.1	9.8	0.4	0.2	-0.8	0.2	-0.0	-0.1	-3.1	-0.9	-0.4	-3.1	-0.1	-0.9	-2.2
Overall health rating	1.7	3.7	8.8	2.8	2.9	0.8	2.2	0.8	2.8	-0.9	2.0	2.0	-0.7	3.0	0.2	-0.7
Chest pain or discomfort	1.7	2.4	7.9	2.4	2.0	1.0	1.2	-0.2	1.7	0.1	2.8	1.4	-0.1	2.0	0.4	1.3
Cardiovascular Disease	1.6	5.2	13.8	3.4	3.7	0.9	2.8	0.6	2.4	-1.8	1.8	2.4	-1.7	3.4	-0.1	0.3
Number of treatments/medications taken	1.6	2.9	6.9	2.6	2.6	0.6	1.4	0.5	2.3	-0.6	1.6	2.2	-1.0	2.5	1.2	-0.7
High blood pressure (mother)	1.6	2.3	6.8	2.3	2.1	1.1	2.6	1.2	1.8	-1.3	1.0	1.4	-0.7	1.1	0.9	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	5.1	-1.9	-1.2	-1.0	-0.7	-2.2	-1.3	-0.8	-2.3	-1.0	0.1	-0.4	-2.1	-0.1
Medication: Cholesterol lowering	1.6	2.5	5.6	2.4	2.3	-0.3	1.1	1.9	1.8	-1.0	1.2	2.1	-0.4	2.1	1.0	-0.7
Smoking status: Previous	1.6	2.4	5.0	-1.2	-1.4	-1.8	-1.4	-1.9	-2.2	-1.7	-1.5	-1.9	-0.4	-1.2	-0.3	-1.8
Supplements: Fish oil (including cod liver oil)	1.6	2.1	10.5	0.5	0.9	1.7	2.1	0.2	0.9	0.6	0.7	0.9	1.5	0.3	3.2	2.1
Irritable Bowel Disease (IBD)	1.5	3.6	10.7	2.5	2.2	1.6	1.5	1.0	2.3	1.1	3.3	1.7	-1.1	1.3	2.5	0.8
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.3	1.8	2.1	0.3	1.3	1.3	1.8	-0.7	0.9	1.8	-1.5	2.0	-0.6	0.1
Supplements: Glucosamine	1.5	2.0	6.0	1.9	1.6	1.6	2.0	0.4	0.9	-1.2	1.3	0.9	0.2	1.4	2.4	-0.0
Pain all over the body in last month	1.5	1.6	5.8	0.7	1.0	0.3	0.4	-0.1	1.5	2.4	0.9	1.4	1.5	1.7	0.2	1.9
Pulse rate	1.5	2.5	6.2	1.5	1.6	0.8	1.2	1.0	1.7	1.3	1.8	1.0	2.1	1.6	-1.6	2.5
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	7.8	-2.8	-1.9	0.1	-1.0	-1.8	-1.6	0.9	-1.9	-2.1	0.2	-1.7	-1.3	0.7
Exposure to tobacco smoke outside home	1.5	2.0	3.3	1.7	1.4	1.7	1.8	0.8	1.7	0.3	1.7	0.7	0.7	1.4	1.8	1.2
Leg pain on walking	1.5	1.9	8.4	1.7	1.6	-0.4	1.6	1.4	1.5	-0.6	1.1	0.9	-0.4	1.3	2.9	-0.2
Illnesses of father: Heart disease	1.5	2.1	9.3	-0.9	-1.3	-1.8	-1.8	-0.6	-1.2	-0.8	-0.9	-0.8	-1.0	-1.3	-1.7	-3.1
Mineral and other dietary supplements	1.5	2.0	9.2	-1.2	-1.2	-1.9	-1.9	-0.2	-1.1	-0.4	-1.0	-1.1	-0.8	-0.9	-3.0	-1.3
High cholesterol (Self-reported)	1.5	2.7	6.0	1.9	2.0	-0.3	1.2	1.3	1.3	-2.4	0.1	1.3	-1.9	2.5	-0.1	-2.4
Ever had hysterectomy (womb removed)	1.4	1.6	5.0	1.2	1.7	1.2	0.6	-0.3	1.8	1.1	2.2	1.0	-0.5	1.2	-1.0	1.1
Worrier / anxious feelings	1.4	2.6	6.6	1.3	2.4	1.3	2.0	0.3	2.6	0.5	0.7	2.2	-0.8	2.2	1.6	-0.4
Noisy workplace	1.4	1.7	5.3	1.0	1.0	1.7	1.1	-0.0	1.4	1.8	1.1	0.5	0.6	0.9	2.3	1.8
Eye problems/disorders: None of the above	1.4	1.6	6.1	-1.6	-0.8	-0.6	-0.4	1.0	-0.6	2.0	-0.3	-0.5	2.5	-0.6	0.8	1.9
Loneliness, isolation	1.4	1.9	5.2	1.7	2.0	0.9	1.5	1.2	2.3	0.2	1.7	1.1	0.8	1.7	0.0	0.1
Long-standing illness, disability or infirmity	1.4	2.1	4.7	2.1	2.0	0.1	0.4	1.9	1.8	-0.9	1.9	1.5	-0.2	2.2	0.5	-0.7
Pack years adult smoking proportion	1.3	2.0	7.2	-1.4	-1.4	-2.2	-2.7	0.6	-1.5	1.5	-0.3	-1.5	1.7	-0.3	0.5	0.7
Medication: Blood pressure	1.3	2.3	7.4	2.7	1.9	0.1	1.2	1.2	1.3	-1.1	1.6	1.9	-0.8	1.4	2.1	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	4.9	1.7	2.2	0.6	2.0	-0.4	1.6	0.0	1.6	2.2	0.8	1.7	0.3	0.6
Miserableness	1.3	2.3	5.8	1.0	1.9	2.0	2.4	1.4	1.9	-0.5	0.7	1.4	-1.2	1.9	1.5	-0.6
Unable to work because of sickness or disability	1.3	1.7	5.4	-0.8	-1.2	-1.6	-2.3	0.7	-1.0	-0.0	-0.6	-0.8	-2.3	-0.9	-0.7	-1.8
Vascular/heart problems diagnosed by doctor	1.3	3.5	9.9	-3.1	-2.8	-1.2	-2.2	-1.0	-2.2	0.8	-2.0	-1.9	-0.5	-2.4	-0.8	-0.9
Fed-up feelings	1.2	2.2	5.6	1.7	2.4	0.6	1.8	0.9	2.3	-0.0	0.8	1.7	-0.8	2.2	1.2	-0.6
Past tobacco smoking	1.2	2.2	4.9	0.6	1.6	2.2	2.2	1.5	2.1	0.9	0.8	1.6	0.0	1.5	0.8	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	6.0	1.0	1.5	0.6	2.5	1.3	1.6	-0.8	-0.6	1.2	0.2	1.2	2.4	-0.5
Pulse wave reflection index	1.2	1.4	2.7	-1.6	-1.6	-0.4	-1.4	-1.0	-1.4	0.6	-1.2	-1.6	1.1	-1.6	0.0	-0.4
Birth weight	1.2	2.7	10.3	-1.7	-1.8	-0.1	-0.7	-0.4	-1.9	-1.0	-3.2	-1.4	-1.2	-1.9	0.7	-2.4
Worry too long after embarrassment	1.2	2.0	6.0	0.4	2.0	1.5	2.5	-0.9	2.1	1.2	-0.2	1.5	-0.8	1.5	1.0	0.6
Ever had bowel cancer screening	1.2	1.4	6.0	-1.0	-1.5	-1.2	-2.4	1.1	-1.2	0.6	-0.4	-0.7	1.1	-0.9	-1.0	-0.8
Osteoarthritis (self-reported)	1.2	1.6	3.7	1.6	1.7	-1.2	1.4	0.9	0.6	-1.4	0.1	1.1	-1.3	1.9	0.6	-1.5
Number of operations (self-reported)	1.2	1.8	4.9	2.2	1.7	1.1	1.4	0.4	2.1	-0.0	1.0	1.3	0.2	2.2	0.2	-0.4
Coronary Artery Disease (CAD)	1.1	1.3	4.6	0.4	1.5	0.5	0.8	0.5	1.7	1.0	0.3	1.7	0.2	2.1	-1.3	-0.4
LDL Cholesterol	1.1	1.8	6.8	1.1	1.5	1.4	0.3	-0.7	1.8	2.6	1.1	1.8	-0.1	1.6	-0.1	0.3
Hearing difficulty/problems: Yes	1.1	1.7	6.0	1.6	1.4	0.8	1.2	0.3	0.9	-1.4	0.7	1.4	-2.4	1.1	0.9	-1.4
Illnesses of mother	1.1	1.3	4.8	-1.5	-1.5	0.4	-1.1	-1.1	-0.8	2.2	-0.0	-1.2	1.1	-1.1	0.1	0.9
Shortness of breath walking on level ground	1.1	1.3	3.1	1.7	1.3	-0.2	0.9	1.7	1.6	-1.7	0.6	0.5	-1.1	0.9	0.6	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.5	-1.6	-1.2	-1.9	-1.7	1.2	-1.0	1.0	-1.3	-0.5	0.4	-0.2	0.3	-0.4
Guilty feelings	1.1	1.6	3.8	1.4	1.9	1.5	1.7	-0.0	1.3	0.2	1.0	1.3	-1.4	1.7	1.2	-0.4
Heart disease (siblings)	1.1	1.4	6.4	-0.4	-0.5	-1.9	-1.2	-1.0	-0.7	-0.4	-0.8	-0.2	-0.1	-0.8	-2.5	-1.8
Neuroticism (2016)	1.0	1.5	3.0	1.0	1.4	0.6	1.7	1.4	1.6	-0.4	0.2	1.2	-0.7	1.2	1.6	-1.4
Height	1.0	19.4	41.6	6.4	6.1	2.0	4.0	3.5	5.5	-0.2	4.2	6.2	1.1	6.0	4.1	-0.7
Diabetes (father)	1.0	1.2	2.8	1.2	1.3	1.6	1.3	0.6	1.7	0.0	1.5	1.5	0.1	0.9	0.3	0.2
Diabetes (mother)	1.0	1.3	6.0	-0.0	-0.0	-0.4	0.1	1.8	-0.3	-1.9	-1.3	0.1	-2.5	-0.3	-0.4	-1.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.4	0.9	1.2	1.1	1.1	-1.0	1.2	0.8	1.2	0.8	-0.3	1.0	-1.3	1.5
Diabetes (self-reported)	1.0	1.5	3.8	2.0	1.7	0.3	1.2	-0.2	1.4	-0.8	1.8	0.7	-1.0	1.8	0.3	-0.9
Time employed in main current job	1.0	1.1	4.4	1.0	0.8	2.1	1.1	1.0	0.6	0.0	0.9	0.4	-1.6	0.6	1.2	0.6
Standing height	1.0	9.9	23.8	4.9	4.4	1.8	3.3	2.0	4.1	-1.0	2.4	4.2	-0.2	3.9	3.3	-0.7
Peak expiratory flow (PEF)	1.0	2.3	5.8	2.1	1.6	0.1	0.7	0.3	1.8	0.6	0.3	2.4	2.2	1.6	-1.4	1.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	13.6	1.4	0.4	0.3	1.5	-0.6	-0.3	-3.7	0.4	-0.1	-0.8	-0.6	0.9	-0.8
Glaucoma (self-reported)	1.0	1.1	5.8	0.8	0.8	0.2	1.1	-1.0	0.4	-2.4	-0.1	0.1	-2.0	-0.2	-1.1	-0.2
Medication for pain relief, constipation, heartburn	1.0	1.6	4.0	-1.2	-1.7	-0.7	-0.5	0.1	-1.6	-1.1	-1.7	-1.2	0.8	-1.9	-2.0	0.2
Qualifications: nursing, teaching	1.0	1.6	4.5	-1.0	-1.1	-0.9	-1.0	0.9	-1.5	-1.9	-2.1	-1.0	-1.1	-0.9	-1.0	-1.5
Medication: Gliclazide	1.0	1.1	3.6	1.9	1.3	-1.1	0.3	0.4	0.4	-1.0	1.3	0.5	0.5	1.1	1.8	0.1
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.4	1.3	1.3	0.5	1.5	0.6	1.8	-0.8	0.4	1.3	-1.0	0.9	-1.2	-0.5
Eye problems/disorders: Glaucoma	1.0	1.2	6.1	1.2	1.2	1.1	1.1	-0.3	1.0	-1.4	0.7	0.4	-2.5	0.2	-0.5	-0.3
Medication: Bendroflumethiazide	1.0	1.5	4.5	2.1	1.4	0.9	1.1	1.7	1.2	-0.6	1.5	1.3	-1.1	0.7	0.7	-0.5
Irritability	1.0	1.7	3.6	1.2	1.9	0.5	1.9	1.0	1.5	-0.5	0.4	1.4	-1.3	1.7	1.6	-0.9
Commuting to job workplace: Cycle	1.0	1.2	3.2	-1.4	-1.2	-1.5	-1.5	0.6	-1.2	0.2	-1.8	-0.8	0.8	0.2	-0.8	-0.3
Impedance of whole body	1.0	5.3	17.8	1.4	2.4	3.3	4.2	1.1	3.2	1.3	1.2	1.7	-0.7	1.3	3.3	1.4
Crohns Disease (2012)	0.9	1.4	2.6	1.4	1.6	0.8	0.6	1.5	1.0	0.8	1.5	1.2	-0.3	1.6	1.2	0.7
Heel T-Score	0.9	7.2	16.3	-4.0	-3.9	-0.4	-3.0	-0.0	-3.4	-0.8	-2.9	-3.9	-1.7	-3.1	-0.4	-2.1
Townsend deprivation index at recruitment	0.9	1.2	5.9	1.8	1.1	-1.5	-0.4	-0.3	0.4	0.4	2.4	1.0	0.7	1.1	0.4	-0.4
Stomach or abdominal pain in last month	0.9	1.1	3.8	1.4	1.6	-0.6	0.9	0.6	1.3	-0.1	0.8	1.4	-0.3	1.9	-0.2	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.3	-1.7	-1.5	-0.9	-0.7	-0.8	-1.8	-2.1	-0.8	-2.0	-1.3	-1.7	-1.6	-0.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.1	0.8	1.5	1.3	1.3	0.6	1.8	-0.0	-0.1	1.4	-0.7	1.2	-0.5	-0.8
Qualifications: A levels/AS levels or equivalent	0.9	2.0	10.3	-0.2	-1.2	-0.9	-0.1	0.2	-2.0	-3.2	-1.3	-1.2	-1.1	-1.8	-0.1	-1.2
Depression (self-reported)	0.9	1.1	4.0	-1.2	-0.5	-1.1	-1.0	-0.2	-1.1	-0.8	-0.9	-0.5	-1.1	-0.4	-2.0	-1.3
Length of working week for main job	0.9	1.0	4.3	0.3	0.6	0.2	0.8	-0.7	0.9	1.4	0.6	0.5	2.1	0.2	0.1	1.7
Medication: Ventolin 100micrograms inhaler	0.9	1.1	4.7	0.0	-0.8	-1.4	-0.5	-1.4	-1.3	-2.2	-0.3	-1.1	-1.0	-0.3	0.2	-0.8
Leg fat percentage (right)	0.9	3.2	9.6	3.1	2.3	0.3	1.1	0.5	2.5	0.5	2.7	1.4	1.2	1.5	1.4	2.0
Wheeze or whistling in the chest in last year	0.9	1.7	6.4	1.5	1.6	-0.7	-0.3	0.6	1.2	0.7	1.9	1.8	0.5	2.5	-0.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	5.2	2.3	1.4	1.2	0.5	1.7	1.1	0.3	1.8	1.4	0.4	0.7	1.9	1.7
Diabetes diagnosed by doctor	0.9	1.5	4.2	1.9	1.8	0.2	1.1	0.6	1.4	-0.7	1.5	0.8	-0.7	2.1	0.1	-0.2
Friendships satisfaction	0.9	1.1	3.4	0.8	1.5	0.5	1.8	-0.6	1.7	0.0	-0.3	1.1	0.4	1.5	0.3	-0.6
Eye problems/disorders: Cataract	0.9	1.0	4.9	1.1	0.5	1.1	1.2	-1.0	0.6	-2.2	-0.9	-0.0	-0.7	0.2	0.3	-1.3
Medication: Aspirin	0.9	1.1	3.4	1.0	1.7	0.8	1.4	0.8	1.8	-0.1	0.3	1.1	-0.0	1.9	0.2	0.1
Medication: Blood pressure	0.9	1.7	4.2	2.1	1.8	0.7	1.7	0.5	1.1	0.2	1.5	0.8	-0.4	1.3	1.3	1.8
Risk taking	0.9	1.3	5.5	0.2	-0.7	0.4	0.3	0.8	-1.1	-2.4	-0.5	-1.5	-1.1	-0.7	1.2	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.5	0.9	1.3	1.3	1.0	-0.0	1.9	0.9	0.6	1.0	-0.1	1.5	0.9	0.2
Schizophrenia vs Biploar Disorder	0.8	1.0	4.5	-1.5	-0.5	-0.0	-1.4	-2.1	-0.1	0.8	-0.6	-0.2	0.6	-0.3	-1.3	1.0
Alzheimer’s Disease (in mother)	0.8	1.0	2.3	1.2	1.3	-0.7	-0.0	-0.8	0.8	-1.1	1.1	1.5	-0.2	1.4	-0.8	-0.8
Prostate Cancer	0.8	1.1	3.3	-1.2	-1.2	1.8	0.6	-0.1	-0.7	-1.0	-1.1	-1.2	-0.2	-1.8	0.1	-0.2
Body Mass Index (BMI) (2010)	0.8	1.1	6.0	-1.0	-1.0	-1.2	-2.5	-0.1	-1.0	0.3	-0.6	-0.5	0.1	-0.7	-1.4	-0.7
Waist Hip Ratio (WHR)	0.8	3.7	14.5	2.4	2.6	1.1	1.7	-0.3	1.8	0.4	1.9	2.3	-0.6	2.0	3.8	0.8
Chronotype (morning person)	0.8	1.8	4.7	-1.9	-1.4	-0.9	-1.3	-1.7	-2.2	-0.3	-1.3	-1.8	-0.4	-1.3	0.4	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	4.0	-1.7	-1.5	-0.4	-1.0	-1.1	-1.8	-1.5	-0.8	-1.8	-1.5	-2.0	-1.0	-0.7
Qualifications: CSEs or equivalent	0.8	1.1	3.3	0.7	-0.1	0.7	0.5	-1.5	-0.9	-1.8	-0.3	-1.2	-1.4	-0.7	1.4	0.7
Had menopause	0.8	1.0	4.6	0.4	0.7	0.1	-0.5	2.1	1.1	0.9	1.7	1.0	-0.2	1.2	0.1	0.4
Medication: Ramipril	0.8	1.0	1.9	1.3	1.1	-1.1	1.0	0.7	0.4	0.5	1.4	0.8	0.8	1.2	1.3	0.5
Medication: Simvastatin	0.8	1.1	5.7	1.7	1.0	-0.5	0.6	0.9	0.2	-2.4	0.5	0.1	-0.8	0.9	0.7	-1.3
Illnesses of siblings	0.8	1.1	5.1	-1.7	-1.1	0.2	-0.3	0.3	-1.2	-0.5	-2.3	-1.0	-0.5	-0.1	1.4	-0.6
Hip circumference	0.8	3.3	9.9	3.1	2.1	-0.7	-0.4	1.3	2.3	1.1	2.7	2.3	1.6	1.9	0.4	0.7
Headache pain in last month	0.8	1.4	3.5	1.2	0.8	1.5	0.6	1.2	1.9	0.5	1.9	0.9	-0.7	0.9	1.7	-0.4
Forced vital capacity (FVC), Best measure	0.8	2.8	6.8	2.2	1.9	1.7	0.8	2.2	2.2	0.4	0.7	2.6	1.3	1.9	0.8	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.8	0.0	-0.7	-0.1	-1.9	-1.4	-0.1	0.9	0.4	-0.4	1.5	-1.0	-1.0	-0.4
Leg fat mass (right)	0.8	3.0	11.8	3.4	2.4	-0.8	0.3	0.8	2.0	-0.2	2.7	1.8	0.9	1.7	1.2	0.9
Medication: Aspirin	0.8	1.0	3.2	1.1	1.6	0.7	1.1	0.6	1.6	-0.0	0.4	1.1	-0.2	1.8	0.4	-0.2
Knee pain experienced in last month	0.8	1.3	6.0	1.4	1.2	-0.6	-0.1	0.2	0.5	-0.1	2.5	1.2	-0.7	1.4	-0.2	-1.6
Ever taken oral contraceptive pill	0.8	0.9	3.9	0.3	0.2	-1.3	-1.4	-2.0	-0.4	0.4	1.0	0.5	-0.1	0.6	-1.3	-0.2
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.6	-1.5	-1.4	-0.2	-0.8	-0.1	-0.5	-0.2	-1.3	-0.6	1.2	-0.4	-1.6	-0.6
Allergy or Eczema	0.7	1.8	6.5	-0.4	-0.6	-0.6	-0.7	-0.6	-1.3	-2.5	-1.1	-0.6	-1.8	-0.6	-2.5	-1.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	4.1	1.1	0.5	-0.3	-0.4	2.0	0.7	-0.7	0.5	0.9	-0.8	0.9	-0.5	-1.6
Average weekly fortified wine intake	0.7	0.8	2.6	-1.6	-0.8	-0.0	-0.7	-1.0	0.0	1.6	-0.0	-0.6	0.8	-0.3	-0.8	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	5.7	-0.5	-0.0	-1.4	0.1	2.4	-0.2	-1.0	-1.4	-0.3	0.5	0.7	-0.8	-0.8
Serious illness, injury or assault to yourself	0.7	0.8	3.7	0.2	0.3	0.6	-0.3	1.9	1.2	0.6	0.2	1.0	0.4	1.1	-1.2	-0.6
Medication: Atenolol	0.7	0.8	4.9	1.4	1.1	0.2	0.5	0.3	0.7	0.4	0.8	0.5	0.1	0.9	2.2	-0.2
Chronic bronchitis/emphysema (father)	0.7	0.8	3.8	0.6	0.4	0.6	-0.6	1.9	0.7	0.8	1.1	0.7	-0.4	1.4	0.1	-0.4
Trunk fat mass	0.7	2.8	10.1	3.2	2.4	-1.1	0.2	1.2	2.0	-0.2	2.0	2.2	-0.1	2.0	1.2	-0.1
Forced vital capacity (FVC)	0.7	2.7	6.1	2.2	1.8	1.4	1.3	1.4	2.2	0.2	0.7	2.5	1.6	1.6	1.4	1.5
Falls in the last year	0.7	0.9	4.7	1.4	0.1	-0.9	-0.2	-1.0	-0.4	-1.1	2.2	-0.1	-0.5	0.3	-0.8	-0.7
Pulse wave Arterial Stiffness index	0.7	0.9	4.6	0.5	-0.1	0.7	0.2	0.7	0.4	0.7	1.5	0.1	2.1	-0.2	0.1	1.5
Comparative body size at age 10	0.7	1.9	4.9	-1.1	-1.5	-2.2	-2.2	1.3	-1.7	-0.0	-1.1	-1.0	0.8	-1.1	-1.8	-0.2
Pulse wave peak to peak time	0.7	0.8	4.9	-0.0	0.5	-0.6	0.1	-0.5	0.0	-0.8	-1.2	0.3	-2.2	0.5	0.1	-1.6
Comparative height size at age 10	0.7	3.9	11.2	3.3	2.7	0.7	1.1	1.5	2.1	-0.9	1.2	3.2	0.8	2.9	1.5	0.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.3	0.8	1.0	-0.0	0.3	-1.5	1.1	1.0	1.3	0.9	-0.7	0.4	-0.8	0.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.2	-1.5	-0.8	-1.3	-1.2	-0.8	-1.1	0.3	-1.0	-1.0	0.0	-0.4	0.2	-0.5
Breast cancer (self-reported)	0.7	0.8	3.2	0.4	-0.0	1.6	1.5	0.4	0.8	-0.5	0.2	-0.0	-0.6	-0.6	1.8	-0.6
Diastolic blood pressure, automated reading	0.7	2.1	6.5	1.7	1.5	1.7	1.5	0.9	0.9	0.9	1.9	0.8	0.6	0.5	1.9	2.5
Depression (Nagel 2018)	0.6	0.8	4.6	0.1	0.5	-0.7	0.7	2.1	0.4	-0.9	-1.5	0.4	0.2	0.9	-0.7	-0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.5	8.4	-0.0	0.2	0.3	1.8	-0.8	-0.8	-2.9	-1.2	-0.7	-1.3	-1.2	0.6	-0.6
Fasting Glucose	0.6	0.7	1.7	-0.4	-1.0	-0.5	-0.7	0.3	-1.3	-1.2	-0.6	-0.9	0.8	-0.7	-0.2	-1.1
HbA1C	0.6	0.7	2.0	-1.2	-1.0	-1.4	-0.7	-0.6	-0.8	-0.5	-0.7	-1.0	0.0	-1.0	0.0	0.1
Rheumatoid Arthritis	0.6	0.9	4.4	-1.5	-0.7	1.3	-0.0	0.1	-0.1	1.4	-2.1	-0.1	0.4	0.1	-0.2	0.3
Smoking Status	0.6	1.5	6.7	2.6	1.3	-1.6	0.7	-0.9	0.8	-0.8	1.6	1.2	0.1	0.8	0.7	-0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	5.0	1.2	1.7	-0.2	0.9	0.1	1.4	0.4	0.9	0.9	0.0	2.2	-0.2	-0.5
Average weekly spirits intake	0.6	0.7	2.5	-1.3	-0.2	0.6	-0.5	-1.3	0.8	1.0	-1.6	-0.1	0.6	0.2	-0.5	0.2
Vitamin and mineral supplements	0.6	0.8	3.8	-0.4	-0.2	-0.1	-1.0	-1.5	0.0	0.6	0.7	-0.5	-1.4	-0.2	-1.9	-0.5
Trunk fat percentage	0.6	2.3	7.2	2.7	2.1	-1.0	0.4	1.2	2.0	0.2	1.7	2.1	-0.3	1.8	1.1	-0.1
Medication: Levothyroxine sodium	0.6	0.9	2.1	1.3	1.1	1.1	1.0	0.1	1.0	-0.5	1.4	1.1	0.6	1.3	-0.5	-0.7
Waist circumference	0.6	2.2	9.2	3.0	1.6	-1.3	-1.1	0.5	1.1	0.0	2.8	1.4	0.5	1.5	0.9	0.2
Hair/balding pattern: Pattern 2	0.6	0.8	4.1	-1.1	-0.6	-0.2	-0.6	-2.0	0.2	1.4	-0.0	-0.4	0.2	-1.3	0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.9	1.3	1.3	0.3	0.5	1.7	1.6	-0.1	0.7	1.1	-0.1	1.3	-0.2	-0.4
Happiness	0.6	0.7	2.4	-0.4	0.0	0.6	1.1	0.6	0.3	-0.8	-1.3	-0.0	-1.5	-0.0	-0.1	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	5.5	2.2	1.6	1.2	0.4	2.1	1.8	0.5	0.4	2.3	0.8	1.4	0.2	0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.1	0.2	1.2	-0.2	1.0	-1.8	0.2	-0.6	0.1	-0.1	-1.7	0.9	0.2	0.0
Whole body fat mass	0.6	2.5	10.1	3.2	2.1	-1.1	-0.1	1.0	1.8	-0.3	2.2	1.9	0.3	1.6	1.1	0.1
Had major operations	0.6	0.7	2.1	-0.4	0.4	-0.4	-0.6	0.7	0.7	0.3	-1.0	0.9	0.0	1.4	-1.4	-1.1
Supplements: Vitamin C	0.6	0.8	2.8	-0.3	-0.3	-1.1	-1.0	0.5	-0.9	-0.9	-0.4	-0.2	-1.5	0.6	-0.1	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.4	1.2	1.1	-0.2	0.4	-0.7	0.3	-0.6	0.5	0.8	-1.1	0.9	1.1	-0.8
Asthma (self-reported)	0.6	1.1	2.3	-1.2	-1.1	-1.3	-1.4	-1.0	-1.4	-0.4	-0.3	-1.2	-0.9	-0.7	-1.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	9.1	0.9	0.2	0.3	-1.0	3.0	0.3	0.6	-0.0	1.0	1.5	0.6	-0.1	0.2
Average weekly champagne plus white wine intake	0.6	0.8	6.1	0.3	0.0	-1.2	0.3	0.6	-0.6	-1.0	-0.5	-0.1	-0.6	0.4	0.7	-2.5
Hearing aid user	0.6	0.7	1.8	1.4	0.6	1.2	1.2	0.0	0.2	-0.7	0.9	0.1	-0.5	-0.2	1.3	0.2
Mother’s age at death	0.6	0.7	4.4	-0.7	-0.6	0.8	1.1	0.3	-0.8	-0.2	-0.7	-0.6	-0.5	-0.7	2.1	-0.1
Alcohol drinker status: Never	0.6	0.7	2.5	-1.3	-1.1	0.9	0.5	-0.6	-0.3	-0.5	-0.8	-1.2	-0.2	-1.6	-0.2	-0.4
Fractured/broken bones in last 5 years	0.6	0.7	1.9	1.0	0.7	0.4	-0.7	0.4	1.1	0.9	0.8	1.4	0.8	1.0	-0.8	-0.2
Leg fat mass (left)	0.6	2.2	8.8	3.0	1.9	-1.2	-0.2	0.8	1.5	-0.2	2.3	1.4	0.9	1.4	0.9	0.6
Alzheimer’s Disease (in father)	0.5	0.5	3.9	-0.6	-0.5	0.9	0.0	-2.0	0.0	0.3	0.5	-0.6	0.5	-0.7	-0.2	0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	2.5	0.8	0.9	0.2	-0.1	-1.1	1.0	-0.3	1.6	0.8	0.2	0.9	-1.3	0.2
Crohns Disease (2017)	0.5	1.1	2.7	0.7	0.9	1.2	0.1	0.7	1.4	1.6	1.6	0.8	-0.4	0.7	1.4	1.1
Breast Cancer	0.5	1.3	6.2	0.0	-0.2	0.5	-0.2	-0.8	0.6	1.5	0.7	0.1	2.1	-0.2	-1.3	2.5
HDL Cholesterol	0.5	0.9	2.1	1.0	0.9	0.8	1.5	1.3	0.6	0.5	1.3	1.1	-0.2	0.8	0.4	1.0
Lupus	0.5	0.8	1.7	-0.6	-0.9	-1.3	-1.1	-0.3	-1.3	-0.7	-0.5	-0.5	1.0	-1.2	-0.8	0.2
Blood Eosinophil Count	0.5	4.0	11.1	-2.4	-2.3	-2.7	-3.3	-0.3	-2.5	-0.5	-1.5	-2.0	0.1	-2.2	-2.3	0.2
Blood Platelet Count	0.5	5.5	11.8	2.8	2.5	1.0	1.8	2.9	3.4	1.8	2.5	2.1	2.3	2.2	2.6	1.6
Medication for hormone replacement therapy	0.5	0.5	3.2	-0.3	-0.2	-0.4	0.2	1.8	-0.4	-0.3	-0.7	-0.6	-1.4	-0.0	0.3	0.3
Supplements: Zinc	0.5	0.6	3.5	0.6	0.1	-0.7	-0.2	-0.0	-0.0	-0.8	-0.6	0.4	-1.2	0.3	0.6	-1.9
Medication: Co-codamol	0.5	0.6	2.0	0.0	0.0	-0.8	-0.6	-0.7	-0.1	-0.5	0.6	-0.5	-1.4	0.6	0.7	-1.4
Severe depression (siblings)	0.5	0.6	3.1	-0.6	-0.6	0.9	0.1	0.4	-0.0	-0.3	-0.7	0.0	-1.7	-0.3	-0.6	-1.2
Hand grip strength (right)	0.5	1.4	9.3	0.3	0.9	3.1	2.0	-0.8	0.7	-0.9	-0.5	0.0	0.2	0.2	1.4	0.1
Relative age voice broke	0.5	0.8	2.3	-0.5	0.6	1.2	1.1	-1.5	0.7	0.8	-0.4	0.3	0.6	0.9	0.6	1.3
Number of incorrect matches in round	0.5	0.9	2.5	-1.6	-1.1	-1.1	-1.3	-0.5	-1.3	0.6	-0.9	-0.9	0.6	-0.2	-0.9	0.2
Qualifications: None of the above	0.5	1.0	4.9	-0.6	0.1	-2.2	-0.9	-1.3	0.2	1.6	-0.0	0.4	1.1	1.1	-0.2	-0.1
Fluid intelligence score	0.5	1.1	5.3	-0.2	0.2	-0.4	0.7	0.1	-0.5	-2.3	-1.5	0.1	-1.5	-0.4	0.2	-1.9
Weight	0.5	2.7	11.3	3.4	2.1	-1.4	-0.7	0.9	1.6	-0.6	2.0	2.1	0.6	2.0	0.2	-0.4
Impedance of arm (right)	0.5	2.3	6.0	1.0	1.6	2.0	2.4	1.1	2.3	1.2	0.8	1.7	-0.9	0.8	1.8	0.5
Alcohol intake versus 10 years previously	0.5	0.7	2.6	0.7	1.1	0.3	1.0	-1.1	0.8	-0.8	-0.3	0.5	-1.6	0.7	-0.1	-0.5
Hair/balding pattern: Pattern 3	0.5	0.7	2.2	0.6	0.6	0.0	1.2	0.6	0.1	-1.4	0.3	0.6	-1.1	0.6	-0.4	-1.5
Loud music exposure frequency	0.5	0.6	2.4	0.8	0.4	-0.4	0.3	-1.5	0.2	-0.6	1.1	0.1	-0.4	0.2	-1.0	-1.1
Body fat percentage	0.5	2.0	7.4	2.7	2.0	-0.9	0.3	0.9	1.9	0.1	1.9	1.7	0.2	1.4	1.1	0.5
Angina (self-reported)	0.5	0.7	2.7	-0.3	-0.5	-0.8	-1.6	1.5	-0.4	0.0	-0.6	-0.6	-0.5	-0.4	0.9	-0.6
Mean time to correctly identify matches	0.5	1.0	2.4	1.0	1.3	-0.3	0.4	0.3	0.2	-0.6	1.0	1.1	-1.6	1.5	-0.5	-1.4
Age at last live birth	0.5	0.7	4.5	-0.0	0.2	0.7	0.8	0.2	0.6	2.1	0.4	0.5	0.8	1.0	1.0	0.6
Back pain experienced in last month	0.5	0.8	4.2	1.4	0.6	-0.0	-0.7	0.6	0.8	-0.0	2.0	0.7	0.1	0.6	-0.6	-0.7
Osteoporosis (self-reported)	0.5	0.6	2.6	0.1	-0.4	-0.7	-0.5	-0.3	-0.6	-1.6	-0.1	-0.6	0.9	-0.4	-0.2	-1.6
Wears glasses or contact lenses	0.5	0.6	2.2	1.0	0.8	0.7	0.1	0.2	0.6	1.0	1.5	0.2	-0.2	0.7	1.1	0.2
Commuting to job workplace: Public transport	0.5	0.6	1.8	-0.7	-0.9	-0.9	-0.4	-0.0	-1.3	-1.0	-0.8	-1.1	0.9	-0.5	-0.0	0.0
Medication: Paracetamol	0.5	0.8	3.0	0.1	-0.3	-1.0	-1.2	-0.7	-0.7	-0.1	0.6	-0.0	-1.4	-0.2	1.1	-1.7
Medication: Lisinopril	0.5	0.6	3.3	0.2	0.0	0.0	0.2	-0.1	-0.4	-1.6	-1.1	-0.9	-1.8	-0.3	0.5	0.4
Medication: Atorvastatin	0.5	0.7	3.4	-0.0	-0.1	-1.2	-1.4	1.9	0.1	-0.3	-0.6	0.2	-0.6	0.5	0.3	-0.9
Leg fat percentage (left)	0.5	1.7	5.8	2.4	1.6	-0.7	0.2	0.4	1.7	0.3	2.1	0.9	1.2	1.1	1.0	1.4
Arm fat-free mass (left)	0.5	2.5	11.1	3.3	2.2	-0.7	0.0	0.5	1.2	-1.6	1.9	1.9	0.0	1.8	1.0	-0.7
Average weekly beer plus cider intake	0.5	0.8	3.4	-0.3	-0.7	0.4	0.6	1.3	-0.6	-0.2	0.0	-0.9	-0.1	-1.4	1.8	1.0
Cholesterol lowering medication	0.5	0.8	6.1	0.6	-0.1	-0.2	0.2	0.4	-0.6	-2.5	-0.1	-1.1	-0.7	-0.2	0.4	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	3.3	0.3	0.1	-1.5	-0.8	1.8	0.1	-0.2	-0.2	1.0	0.1	1.1	-0.4	-0.5
Alcohol drinker status: Previous	0.5	0.6	2.0	-0.2	0.9	-0.5	0.5	-0.6	0.5	-0.7	-0.2	0.9	-1.4	1.2	0.3	-0.9
Arm predicted mass (left)	0.5	2.8	11.8	3.4	2.4	-0.5	0.2	0.5	1.4	-1.4	1.9	2.2	0.1	2.1	0.8	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.6	-0.9	-1.1	-0.4	-0.1	0.3	-1.7	-1.7	-1.4	-1.1	-0.5	-1.9	0.6	-0.6
Schizophrenia (2018)	0.4	0.8	3.0	-0.6	0.2	-0.3	-0.6	-1.3	0.6	1.7	0.4	0.5	0.7	0.8	-1.5	-0.6
Reaction Time	0.4	0.7	1.7	0.9	1.1	0.2	0.7	-0.4	0.2	-0.6	1.2	0.8	-1.3	1.2	-0.7	-0.7
Schizophrenia (2014)	0.4	1.0	3.8	-0.2	0.4	-0.4	-0.7	-1.4	0.7	2.0	1.3	0.9	0.9	1.4	-0.6	-0.1
Blood White Count	0.4	3.0	11.1	0.6	0.5	-3.2	-1.9	0.6	0.4	1.2	1.7	0.2	2.4	0.3	-1.4	3.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.3	0.5	0.9	-0.3	0.7	1.5	0.8	0.2	-0.0	1.1	0.5	0.9	-0.6	0.4
Angina	0.4	0.5	2.4	0.0	-0.2	-0.8	-1.6	1.4	-0.3	-0.0	-0.3	-0.3	-0.5	-0.1	0.9	-0.5
Financial difficulties in last 2 years	0.4	0.6	3.0	-0.3	-0.5	0.6	-0.6	-0.0	-0.3	1.1	0.5	-0.7	1.1	-0.1	0.7	1.7
Allergy	0.4	1.0	5.5	0.5	0.2	1.0	0.5	0.1	1.2	1.6	0.9	0.5	1.1	-0.2	2.4	-0.3
Father’s age at death	0.4	0.5	1.6	-0.3	-0.6	0.7	0.4	0.1	-0.2	-1.2	-0.3	-1.0	-0.3	-0.9	-1.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.2	2.0	1.3	0.9	0.5	1.2	1.5	0.2	0.2	2.1	0.8	1.0	0.3	1.1
Mouth/teeth dental problems: Dentures	0.4	0.6	3.3	0.0	0.8	-0.1	-0.4	1.8	0.8	0.7	0.1	1.1	-0.5	1.2	0.3	-0.1
Asthma	0.4	0.8	1.7	-0.8	-0.8	-1.0	-0.9	-1.0	-1.2	-0.6	0.1	-1.0	-1.1	-0.6	-1.3	0.0
Impedance of arm (left)	0.4	1.9	6.0	0.5	1.2	1.9	2.5	1.2	2.1	1.3	0.4	1.2	-0.4	0.8	1.7	0.6
Arm fat mass (right)	0.4	1.6	6.3	2.5	1.6	-1.4	-0.8	0.8	1.2	-0.2	1.8	1.5	0.3	1.3	0.0	-0.2
Trunk predicted mass	0.4	2.2	9.1	3.0	2.0	-0.4	-0.1	0.6	1.3	-1.1	1.6	2.0	0.4	2.0	0.6	-0.3
Breastfed as a baby	0.4	0.5	1.8	0.6	-0.2	-0.1	0.1	0.2	-0.4	-1.3	0.2	0.2	-1.1	-0.7	0.4	-1.2
Blood clot in the leg (DVT)	0.4	0.6	2.5	0.5	0.4	-1.0	-0.4	1.6	0.4	-0.1	0.2	1.2	0.0	1.2	-0.3	-0.1
Medication: Paracetamol	0.4	0.7	2.2	0.7	0.5	-0.6	-1.0	-0.5	0.1	0.4	1.2	0.7	-1.5	0.9	0.9	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.2	0.6	0.6	1.1	1.5	-0.2	0.9	-1.4	-0.5	0.4	0.6	0.8	-0.5	-1.0
Medication: Amlodipine	0.4	0.6	2.3	0.3	0.7	1.5	0.7	-0.1	0.6	0.3	-0.2	0.6	-1.2	1.0	0.7	0.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.6	0.1	0.4	1.3	0.4	1.0	0.9	0.5	0.2	0.6	1.1	0.2	0.7	0.9
Arm fat-free mass (right)	0.4	1.9	7.8	2.8	1.8	-1.0	-0.2	0.5	0.9	-1.3	1.6	1.6	0.3	1.7	1.0	-0.6
Qualifications: College or University degree	0.4	1.3	4.7	-0.4	-0.9	-0.3	0.0	1.4	-1.3	-2.0	-1.0	-0.6	-0.5	-1.2	-0.6	-2.2
Medication: Allopurinol	0.4	0.5	2.0	-0.2	-0.5	-0.5	-0.3	0.7	-0.6	-1.4	-0.8	-0.5	-1.3	-0.2	0.5	-0.5
Commuting to job workplace: Walk	0.4	0.4	1.0	-0.1	0.4	0.2	0.7	1.0	0.5	0.9	0.4	0.7	0.9	0.5	0.6	0.7
Medication for cholesterol	0.4	0.6	3.2	-0.6	-0.1	-0.0	-0.3	-0.6	0.6	1.6	-0.1	1.0	1.8	-0.2	0.3	0.4
Arm fat mass (left)	0.4	1.4	5.7	2.4	1.3	-1.7	-0.9	1.0	1.0	-0.4	1.7	1.3	0.4	1.1	0.0	-0.2
Basal metabolic rate	0.4	2.1	8.9	3.0	1.9	-1.1	-0.6	0.7	1.1	-1.1	1.5	2.0	0.4	1.8	0.3	-0.6
Ever depressed for a whole week	0.4	0.6	4.2	-0.6	0.3	-0.2	-0.1	-0.6	0.6	-0.7	-1.0	0.3	0.1	0.3	-2.1	-0.2
Bipolar Disorder (2018)	0.3	0.5	1.2	0.1	-0.8	-0.2	0.4	0.6	-1.0	-1.0	-0.0	-0.9	-0.1	-1.1	1.0	-0.6
Major Depression (MDD)	0.3	0.3	1.3	-0.5	-0.8	0.5	-0.4	0.5	-0.2	0.1	0.2	-0.3	1.1	-0.9	-0.1	0.4
Age at First Birth	0.3	0.4	1.7	-0.2	-0.1	0.0	-1.0	1.0	0.3	0.1	-0.8	1.0	-0.3	0.4	-0.4	-1.3
Mean Putamen Volume	0.3	0.3	1.1	-0.3	0.2	0.6	-0.1	-1.1	0.8	0.8	-0.0	0.3	-0.4	0.4	-1.0	-0.1
Triglycerides	0.3	0.5	1.6	0.9	0.9	0.4	0.7	0.9	0.8	0.4	1.2	0.4	-0.0	0.5	1.0	0.4
Hypothyroidism (self reported)	0.3	0.6	2.0	0.3	0.2	0.4	1.4	-0.7	0.8	-1.1	-0.6	0.3	1.0	0.4	-0.2	-1.2
Respiratory disease	0.3	0.6	2.0	-0.6	-0.7	0.0	-0.5	-0.9	-0.6	-0.9	0.1	-0.8	-0.8	-0.9	-1.4	0.6
Lung FEV1/FVC ratio	0.3	1.4	5.2	1.0	-0.4	-1.1	-1.6	1.1	-0.3	0.4	-0.5	-0.1	-2.3	-0.7	-1.9	-1.5
Hand grip strength (left)	0.3	0.8	6.1	-0.5	0.2	2.5	1.2	-1.1	0.2	-0.7	-0.9	-0.2	0.4	-0.1	-0.0	0.3
Leg fat-free mass (left)	0.3	1.4	5.1	2.3	1.2	-1.7	-1.0	0.5	0.4	-1.2	0.9	1.6	0.5	1.2	-0.1	-1.0
Taking other prescription medications	0.3	0.4	1.2	0.8	0.8	-0.0	0.0	0.6	1.0	-1.1	0.3	0.5	0.1	0.9	0.1	-1.0
Sitting height	0.3	1.9	4.8	2.1	1.7	0.3	0.6	1.4	1.8	0.2	1.0	2.2	1.5	1.9	0.7	-0.1
Body mass index (BMI)	0.3	1.1	4.8	1.3	0.3	-2.2	-2.1	0.0	-0.1	0.0	1.0	0.3	0.7	0.4	-1.1	-0.1
Leg predicted mass (left)	0.3	1.4	5.0	2.2	1.2	-1.8	-1.0	0.5	0.4	-1.2	0.9	1.6	0.4	1.2	-0.2	-1.0
Heart attack	0.3	0.3	1.0	-0.0	0.0	-0.0	0.0	0.8	0.2	0.5	-0.8	0.3	1.0	0.1	0.9	1.0
Arm fat percentage (right)	0.3	1.1	4.0	2.0	1.2	-1.4	-0.8	0.7	1.1	0.1	1.4	1.2	0.3	0.9	-0.3	0.1
Trunk fat-free mass	0.3	1.9	8.3	2.9	1.9	-0.5	-0.3	0.6	1.2	-1.2	1.5	1.9	0.4	1.8	0.6	-0.4
Gout (self-reported)	0.3	0.5	3.0	-0.2	0.1	0.8	0.2	1.0	0.3	0.3	-0.1	-0.1	0.3	0.6	0.6	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	2.1	-1.1	-0.4	-0.1	-0.4	0.0	-0.7	-0.5	-1.4	-0.5	-0.4	0.3	-0.4	0.1
Migraine (self-reported)	0.3	0.4	1.2	0.0	-0.6	-1.1	-0.9	-0.5	-0.3	0.5	0.3	-0.1	0.8	-0.3	0.9	-1.0
Arm predicted mass (right)	0.3	1.8	7.0	2.7	1.8	-1.0	-0.1	0.3	0.9	-1.4	1.4	1.6	0.3	1.7	0.9	-0.6
Pulse rate, automated reading	0.3	1.0	3.3	-0.3	-0.2	-0.7	-1.3	-0.8	-0.6	1.1	0.9	-0.4	0.9	-0.3	-1.8	1.7
Alcohol intake frequency.	0.3	0.7	3.9	-0.9	0.2	-0.6	0.0	-1.6	0.6	-0.4	-0.4	-0.1	-1.1	0.1	-2.0	-0.5
Family relationship satisfaction	0.3	0.3	1.7	0.3	-0.1	-0.0	0.3	1.3	0.2	0.5	0.3	0.2	1.3	0.4	0.1	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	2.3	0.3	-0.2	0.7	0.8	0.4	-0.1	-0.1	0.3	-0.5	-0.3	-0.8	1.5	0.1
Illnesses of siblings: Diabetes	0.3	0.3	1.9	0.1	-0.3	-0.5	-1.4	-0.4	-0.2	-0.2	0.3	-0.8	0.8	-0.4	-0.1	0.4
Whole body fat-free mass	0.3	1.5	6.3	2.5	1.5	-1.2	-0.8	0.5	0.7	-1.2	1.1	1.7	0.4	1.5	0.3	-0.8
Leg fat-free mass (right)	0.3	1.5	6.0	1.6	0.6	-2.4	-1.8	0.5	-0.2	-1.3	0.2	1.1	0.4	0.9	-0.8	-1.6
Illnesses of father: None of the above (group 1)	0.3	0.4	1.3	-0.5	0.2	0.7	1.1	-0.8	0.1	0.2	-0.6	-0.3	0.9	0.1	0.5	1.0
Whole body water mass	0.3	1.7	7.1	2.7	1.6	-1.2	-0.7	0.5	0.7	-1.4	1.2	1.7	0.3	1.6	0.2	-0.9
Leg predicted mass (right)	0.3	1.6	6.0	1.6	0.6	-2.5	-1.8	0.5	-0.2	-1.4	0.2	1.1	0.2	0.9	-0.8	-1.8
Ever smoked	0.3	0.5	1.4	0.3	-0.6	-0.8	-1.1	-0.8	-0.8	-0.7	-0.0	-0.6	0.2	-0.9	-0.3	-1.2
Age started oral contraceptive pill	0.3	0.4	2.3	-0.2	0.0	0.7	-0.7	-0.0	0.4	0.0	0.3	0.5	-0.5	0.3	-0.8	-1.5
Myopia	0.3	0.4	2.7	-0.6	-0.0	-0.1	-0.2	-0.6	0.3	0.4	-1.1	0.4	-0.2	0.0	-1.6	0.2
Primary Biliary Cirrhosis	0.2	0.3	2.4	-0.2	0.1	0.2	-0.8	0.4	0.4	1.6	-0.2	0.5	-0.5	0.2	0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.8	-0.8	0.1	-0.9	-0.2	0.1	0.2	0.5	-0.5	-0.2	-0.1	-0.2	-0.5
BMI	0.2	1.3	6.0	1.0	0.5	-2.0	-2.5	0.7	-0.0	0.5	0.6	0.7	0.3	1.0	-1.7	0.2
Lung FVC	0.2	0.8	2.5	0.9	0.6	0.4	-0.1	1.5	0.6	0.7	1.0	1.6	0.7	0.7	-0.9	0.3
Medication: Metformin	0.2	0.3	1.1	0.4	0.8	-0.1	0.0	0.1	0.6	0.1	0.6	-0.2	-0.8	1.1	0.5	0.2
Maternal smoking around birth	0.2	0.3	1.3	-0.2	0.3	-0.8	-0.5	1.1	0.2	0.7	0.8	-0.0	0.2	0.4	-0.7	0.3
Age when periods started (menarche)	0.2	0.4	1.8	-0.7	-0.1	-0.1	-0.6	-0.9	-0.3	1.0	-0.0	-0.2	-0.6	-0.5	-1.4	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	3.1	0.3	0.5	0.1	0.2	-0.3	-0.3	-1.4	-0.2	0.1	-0.5	0.7	-1.8	0.3
Alcohol usually taken with meals	0.2	0.2	0.7	0.1	-0.3	-0.5	-0.8	0.8	-0.4	-0.6	-0.3	0.2	-0.4	0.1	-0.5	-0.6
Mouth/teeth dental problems	0.2	0.3	1.2	0.3	-0.8	1.1	-0.1	-0.5	-0.1	0.3	0.3	-0.4	0.9	-1.0	-0.4	-0.1
Number of live births	0.2	0.2	0.7	0.3	0.5	0.3	0.8	0.3	0.6	0.1	0.8	0.4	0.2	0.2	-0.4	-0.4
Prospective memory result	0.2	0.2	0.9	-0.0	-0.4	-0.4	0.3	0.2	-0.6	-0.3	0.4	-0.7	0.4	-0.2	0.5	1.0
Hair/balding pattern: Pattern 4	0.2	0.4	1.3	0.8	0.6	-1.1	-0.5	1.0	0.0	0.3	0.7	0.5	-0.6	0.7	0.0	0.0
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.9	-0.4	0.1	0.7	0.4	0.6	0.3	-0.2	-1.0	0.4	0.3	0.6	-0.4	-0.4
Number of full brothers	0.2	0.3	0.9	0.3	0.3	0.0	0.5	-0.9	0.9	0.5	0.7	0.2	0.4	0.3	-0.5	0.1
Number of children fathered	0.2	0.2	1.7	-0.2	-0.3	0.4	-0.2	-0.0	0.1	0.2	0.3	-0.4	0.3	-0.6	1.3	-0.3
Age at first live birth	0.2	0.4	2.0	0.3	-0.0	1.0	-0.1	-0.2	-0.1	1.3	0.1	0.2	-0.6	0.1	1.4	-0.1
Emphysema/chronic bronchitis	0.2	0.3	0.7	-0.7	-0.5	0.3	0.3	0.3	-0.6	-0.5	-0.6	-0.9	0.5	-0.3	-0.8	0.1
Number of full sisters	0.2	0.2	1.2	0.3	0.1	0.3	-0.0	0.1	0.4	0.3	0.3	-0.2	0.3	-0.9	-0.2	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.6	0.1	0.0	0.1	-0.6	-0.3	-0.0	1.3	0.4	0.4	0.2	0.2	-0.1	0.2
Arm fat percentage (left)	0.2	0.8	3.0	1.6	0.8	-1.7	-1.0	0.6	0.7	0.1	1.0	0.9	0.4	0.7	-0.4	0.1
Average weekly red wine intake	0.2	0.3	1.1	0.1	0.2	0.0	0.2	1.1	-0.1	-0.7	-0.8	0.3	-0.1	0.7	-0.9	0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	0.2	-0.0	0.4	-0.4	0.6	0.3	-0.3	0.1	-0.3	-0.5	-0.2	0.5	-0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.0	0.0	-0.1	-0.4	-0.1	0.6	-0.1	0.3	-1.0	0.1	0.9	0.0	0.6	0.7
Bipolar Disorder or Schizophrenia	0.1	0.2	0.8	-0.4	-0.4	-0.4	-0.3	-0.7	-0.1	0.6	0.3	-0.2	0.5	-0.1	-0.5	-0.9
Ovarian Cancer	0.1	0.2	0.8	-0.3	0.3	-0.1	-0.5	0.3	0.1	0.2	-0.2	0.4	-0.9	0.4	-0.4	-0.5
Blood Red Count	0.1	1.1	6.4	1.2	1.2	-0.6	0.8	-2.5	1.0	-1.0	0.0	0.7	-0.8	0.6	0.1	-0.6
Tanning	0.1	1.3	3.6	0.6	1.3	1.9	1.5	0.9	1.2	1.1	0.8	1.1	-0.4	1.7	0.7	0.2
Relative age of first facial hair	0.1	0.3	1.1	-0.6	-0.5	-0.7	-0.1	-0.5	-1.1	-0.5	-0.6	-0.5	0.0	-0.0	-0.1	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.5	-0.0	0.2	-0.1	-0.3	-0.2	0.0	0.7	-0.0	-0.2	0.4	0.3	0.7	0.3
Had other major operations	0.1	0.1	0.4	0.4	0.2	0.0	0.6	0.0	0.2	-0.6	-0.5	0.3	0.1	0.1	0.0	-0.4
Medication: Omeprazole	0.1	0.2	0.6	-0.2	-0.2	0.5	-0.1	-0.7	0.5	0.8	0.0	-0.3	0.4	0.3	0.3	0.2
Bipolar Disorder (2011)	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.3
Hair Pigment	0.0	1.3	3.7	1.4	0.9	1.9	1.4	1.1	1.6	-0.2	1.2	1.1	-1.1	-0.1	0.7	-0.2

Hub : Genes

RNF130

Models

Trait associations