TWAS hub - NUDT3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.110	0.0420	0.0043	0.034	NA	0.005	NA	0.021	1.4e-03	NA	1.3e-01	NA	9.2e-03
2	GTEx	Esophagus Muscularis	0.123	0.0510	0.0040	0.002	NA	0.008	NA	0.017	2.3e-01	NA	9.6e-02	NA	3.2e-02
3	YFS	Blood	0.119	0.0209	0.0000	0.122	0.108	0.121	0.126	0.130	8.5e-38	2.6e-33	2.6e-37	4.1e-39	2.5e-40

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Arm fat-free mass (right)	12.5	64.1	112.4	-6.3	-10.6	6.4
Arm predicted mass (left)	12.5	63.8	110.2	-6.4	-10.5	6.4
Trunk predicted mass	12.4	70.6	123.2	-6.1	-11.1	7.1
Trunk fat-free mass	12.3	70.4	123.2	-6.1	-11.1	7.1
Arm fat-free mass (left)	12.3	62.5	108.2	-6.4	-10.4	6.2
Arm predicted mass (right)	12.1	61.8	108.2	-6.2	-10.4	6.3
Whole body water mass	11.9	67.7	116.6	-6.5	-10.8	6.6
Whole body fat-free mass	11.7	67.0	114.5	-6.6	-10.7	6.6
Basal metabolic rate	11.5	63.9	108.2	-6.8	-10.4	6.2
Leg predicted mass (right)	10.0	53.1	89.2	-6.3	-9.4	5.6
Leg fat-free mass (left)	9.9	52.2	87.6	-6.3	-9.4	5.4
Leg fat-free mass (right)	9.8	52.3	87.8	-6.2	-9.4	5.5
Leg predicted mass (left)	9.7	51.4	86.1	-6.3	-9.3	5.3
Impedance of arm (right)	8.9	41.6	81.0	-0.4	9.0	-6.6
Weight	8.7	42.9	65.0	-6.8	-8.1	4.2
Hip circumference	8.5	36.5	55.2	-6.3	-7.4	3.9
Impedance of arm (left)	8.3	38.6	72.9	-0.9	8.5	-6.5
Impedance of whole body	8.3	42.5	83.2	0.1	9.1	-6.7
Impedance of leg (left)	6.4	31.1	62.2	0.9	7.9	-5.5
Body Mass Index (BMI) (2010)	6.3	8.7	15.1	-2.4	-3.9	2.3
Impedance of leg (right)	5.8	28.1	57.3	1.1	7.6	-5.1
Age at First Birth	5.0	7.3	10.0	1.5	3.1	-3.2
Height	4.7	90.2	179.6	-13.4	-9.1	3.0
Arm fat mass (left)	4.7	19.5	28.5	-4.8	-5.3	2.5
BMI	4.6	26.9	55.2	-2.9	-7.4	4.2
Forced vital capacity (FVC)	4.6	17.6	26.7	-3.6	-5.2	3.6
Standing height	4.5	44.5	84.5	-9.2	-6.2	3.1
Arm fat mass (right)	4.3	17.9	25.6	-4.8	-5.1	2.2
Leg fat mass (right)	4.3	16.7	23.9	-4.9	-4.8	1.9
Leg fat mass (left)	4.3	16.9	25.4	-5.0	-4.7	1.7
Forced expiratory volume in 1-second (FEV1)	4.2	14.2	20.2	-2.0	-4.5	4.3
Whole body fat mass	4.2	17.4	30.4	-5.5	-4.4	1.5
Body mass index (BMI)	3.9	16.4	32.1	-2.9	-5.7	3.0
Trunk fat mass	3.9	16.8	35.6	-6.0	-3.7	0.9
Allergy or Eczema	3.7	9.7	16.5	0.1	4.1	-3.6
Forced expiratory volume in 1-second (FEV1), predicted	3.7	7.7	12.1	-0.8	-3.2	3.5
Primary Biliary Cirrhosis	3.6	5.2	11.6	-3.4	0.3	-2.0
Sitting height	3.6	25.6	43.2	-6.6	-5.5	1.7
Comparative height size at age 10	3.6	19.9	34.2	-5.8	-4.2	2.8
Blood Platelet Count	3.5	40.5	68.9	7.2	8.3	-1.2
Bilateral oophorectomy (both ovaries removed)	3.5	4.0	5.7	2.3	-1.1	2.4
Mouth/teeth dental problems: Dentures	3.5	5.9	13.1	0.7	-3.6	2.0
Peak expiratory flow (PEF)	3.5	8.2	17.6	0.0	-2.7	4.2
Forced vital capacity (FVC), Best measure	3.5	12.8	19.4	-2.6	-4.4	3.5
Waist Hip Ratio (WHR)	3.4	15.3	22.8	4.8	4.2	-2.4
Risk taking	3.3	4.8	8.3	0.3	-2.4	2.9
Medication: Ibuprofen (e.g. Nurofen)	3.1	4.0	7.6	-0.9	1.9	-2.8
Mineral and other dietary supplements	3.1	4.2	6.9	0.9	-2.2	2.6
Waist circumference	3.0	11.0	19.4	-2.7	-4.4	2.5
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.5	14.4	-1.2	-3.5	3.8
Supplements: Calcium	3.0	3.3	5.9	0.1	2.0	-2.4
Mean Putamen Volume	2.8	3.2	7.2	-0.6	1.4	-2.7
Alcohol intake versus 10 years previously	2.8	4.1	8.4	2.9	-0.6	1.9
Mouth/teeth dental problems: Bleeding gums	2.8	3.6	6.5	0.2	2.5	-2.1
Osteoarthritis (self-reported)	2.7	3.6	6.2	-0.7	2.0	-2.5
Illnesses of father: High blood pressure	2.7	3.3	7.4	2.7	1.6	0.2
Sensitivity / hurt feelings	2.6	4.4	6.7	2.6	2.5	-0.4
Alcohol drinker status: Previous	2.6	3.0	5.3	-1.4	1.3	-2.3
Neuroticism (Nagel 2018)	2.5	6.0	8.8	2.2	3.0	-2.1
Medication for cholesterol	2.5	3.8	6.7	-2.6	0.5	-2.1
Supplements: Fish oil (including cod liver oil)	2.5	3.2	5.6	-0.6	1.9	-2.4
Bipolar Disorder (2018)	2.4	3.7	6.5	-2.6	-2.1	0.2
Falls in the last year	2.4	3.2	4.5	-1.9	1.3	-2.1
Worry too long after embarrassment	2.4	4.0	10.1	3.2	1.4	0.3
Worry (Nagel 2018)	2.3	4.8	7.6	1.9	2.8	-1.8
Blood White Count	2.3	16.7	34.3	5.9	4.0	0.4
Medication: Ramipril	2.3	2.9	3.7	1.9	-1.9	1.3
Worrier / anxious feelings	2.3	4.4	10.4	0.7	3.2	-1.5
Medication: Ibuprofen	2.3	2.7	5.5	-0.4	1.6	-2.3
Alzheimer’s Disease (in mother)	2.2	2.6	4.5	2.1	0.1	1.8
Major Depression (MDD)	2.2	2.7	4.8	-2.2	-1.8	0.5
Lung FEV1/FVC ratio	2.2	11.2	16.5	3.8	-1.6	4.1
Diabetes (mother)	2.2	2.8	4.4	1.7	-1.0	2.1
Trunk fat percentage	2.2	8.7	23.9	-4.9	-0.9	-1.1
Qualifications: O levels/GCSEs or equivalent	2.2	3.5	7.3	2.7	-0.9	1.5
Hayfever, allergic rhinitis or eczema	2.1	4.6	7.2	0.4	2.7	-2.5
Guilty feelings	2.1	3.2	6.7	2.6	1.6	-0.4
Fractured/broken bones in last 5 years	2.0	2.6	3.8	1.6	-1.2	2.0
Neuroticism (2016)	1.9	2.7	6.4	0.1	2.5	-1.3
Blood Eosinophil Count	1.9	14.3	35.5	1.2	6.0	-2.4
Type 2 Diabetes (T2D) (2018)	1.9	3.5	6.4	2.5	2.0	-0.4
Systolic Blood Pressure	1.8	9.0	14.6	3.1	3.8	-1.6
Medication: Amlodipine	1.8	2.5	4.6	2.1	1.7	0.1
Heart disease (mother)	1.8	2.1	4.6	2.1	-0.2	1.3
Medication: Blood pressure	1.8	3.5	7.5	2.7	-0.0	1.7
Supplements: Zinc	1.7	1.9	4.4	0.4	2.1	-1.0
Allergy	1.7	4.0	6.7	0.4	-2.3	2.6
Length of working week for main job	1.7	1.9	3.1	1.8	-0.7	1.4
Hair/balding pattern: Pattern 4	1.7	4.0	10.4	3.2	1.2	0.3
Body fat percentage	1.7	6.9	18.7	-4.3	-1.1	-0.9
Neck or shoulder pain in last month	1.7	2.4	4.9	-0.4	1.5	-2.2
Alcohol drinker status: Never	1.7	2.1	2.5	-1.6	-1.6	1.1
Fasting Glucose	1.6	1.9	3.3	1.8	-0.8	1.3
Rheumatoid Arthritis	1.6	2.3	5.1	-2.3	0.3	-1.3
Hearing difficulty/problems: Yes	1.6	2.4	4.2	-0.3	1.7	-2.1
Depression (self-reported)	1.6	1.9	5.2	2.3	0.3	0.7
Age at last live birth	1.6	2.4	5.0	-0.0	2.2	-1.4
Leg pain on walking	1.6	2.0	4.9	-0.3	-2.2	1.0
Age started oral contraceptive pill	1.6	2.0	3.1	-0.3	1.7	-1.8
Commuting to job workplace: Cycle	1.6	1.9	3.5	-0.1	-1.9	1.5
HDL Cholesterol	1.5	2.6	3.2	-1.7	1.2	-1.8
Heel T-Score	1.5	11.9	29.7	5.5	2.4	0.6
Qualifications: None of the above	1.5	3.2	4.9	-2.2	1.3	-1.7
Mouth/teeth dental problems: Loose teeth	1.5	1.7	3.0	-1.4	0.4	-1.7
Supplements: Vitamin C	1.5	1.8	2.5	1.5	1.6	-0.7
Loneliness, isolation	1.5	2.1	2.6	1.6	-1.5	1.2
Medication: Aspirin	1.5	1.9	4.2	2.1	-0.1	1.2
Hearing aid user	1.5	1.7	3.5	-1.9	-0.3	-1.2
Number of operations (self-reported)	1.5	2.3	5.9	-0.5	-2.4	0.8
Severe depression (siblings)	1.4	1.6	2.6	1.2	-0.9	1.6
Serious illness, injury or assault to yourself	1.4	1.7	2.8	0.5	-1.4	1.7
Time employed in main current job	1.4	1.7	2.0	-1.3	1.1	-1.4
High blood pressure (siblings)	1.4	2.0	6.0	2.4	-0.1	0.4
Medication: Aspirin	1.4	1.8	4.4	2.1	-0.3	0.9
Arm fat percentage (left)	1.4	5.6	12.9	-3.6	-2.0	0.0
Breast cancer (self-reported)	1.4	1.6	1.9	-1.4	1.3	-1.1
Wears glasses or contact lenses	1.4	1.6	2.4	0.0	1.5	-1.6
Leg fat percentage (left)	1.4	5.0	12.7	-3.6	-1.5	-0.4
Basal cell carcinoma (self-reported)	1.4	1.6	4.5	2.1	0.4	0.5
Average weekly fortified wine intake	1.3	1.5	3.1	0.2	1.8	-1.2
Nervous feelings	1.3	2.4	3.2	1.6	1.8	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	7.5	2.7	0.7	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.4	-1.4	-1.6	0.1
Neuroticism	1.2	2.9	7.6	2.8	1.0	-0.1
Average weekly spirits intake	1.2	1.5	3.1	0.5	-1.8	1.0
Frequency of depressed mood in last 2 weeks	1.2	1.6	2.9	1.7	-1.0	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	7.2	2.7	0.9	0.3
Arm fat percentage (right)	1.2	4.7	11.1	-3.3	-1.7	-0.0
Exposure to tobacco smoke at home	1.2	1.3	2.1	-1.4	-1.4	-0.1
Medication: Ventolin 100micrograms inhaler	1.2	1.6	2.5	0.6	1.6	-1.4
Leg fat percentage (right)	1.2	4.5	10.8	-3.3	-1.7	-0.1
Medication: Allopurinol	1.2	1.6	2.9	1.1	1.7	-0.7
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.1	-1.4	1.2	-0.7
Ever had hysterectomy (womb removed)	1.1	1.3	3.3	0.2	-0.6	1.8
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.0	1.2	1.4	-0.7
Number of incorrect matches in round	1.1	1.9	4.2	2.1	1.2	0.3
Pain all over the body in last month	1.1	1.1	2.9	-0.4	0.5	-1.7
Illnesses of siblings	1.1	1.6	2.5	-1.6	-1.4	0.5
Breastfed as a baby	1.1	1.3	3.3	-1.8	-0.7	0.5
Medication: Paracetamol	1.1	1.8	3.4	-0.7	1.2	-1.9
Glaucoma (self-reported)	1.1	1.3	2.9	0.9	1.7	-0.2
Mood swings	1.1	2.0	3.3	1.8	1.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	4.4	0.8	-1.5	2.1
Bipolar Disorder or Schizophrenia	1.0	2.5	6.0	-2.5	-1.2	-0.1
Alzheimer’s Disease (including proxy)	1.0	1.5	2.7	1.6	1.2	0.7
HbA1C	1.0	1.1	2.5	0.8	1.6	-0.1
Lupus	1.0	1.5	2.1	-1.2	-0.9	-1.5
Systolic blood pressure, automated reading	1.0	2.8	4.9	1.1	2.2	-1.5
Townsend deprivation index at recruitment	1.0	1.3	2.2	-1.5	-1.3	0.0
High blood pressure	1.0	2.8	6.9	2.6	1.1	0.5
Had menopause	1.0	1.3	2.1	-1.0	1.4	-0.8
Birth weight of first child	1.0	1.9	5.2	0.6	-0.3	2.3
Blood clot in the leg (DVT)	1.0	1.2	2.1	-1.5	-1.0	0.8
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.4	-2.3	-0.6	-0.1
Comparative body size at age 10	1.0	2.7	5.4	-0.6	-2.3	1.5
Health satisfaction	1.0	1.4	2.5	-1.2	-0.1	-1.6
Emphysema/chronic bronchitis	1.0	1.1	2.2	-0.3	1.0	-1.5
Eye problems/disorders: Glaucoma	1.0	1.1	1.7	1.3	1.3	-0.0
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	1.9	-1.4	-1.0	0.9
Breast Cancer	0.9	2.1	4.3	0.3	-2.1	1.4
Cardiovascular Disease	0.9	2.8	6.2	2.5	0.7	1.4
Hypothyroidism (self reported)	0.9	2.1	3.9	-2.0	-1.2	0.9
Vitamin and mineral supplements	0.9	1.2	2.0	-0.8	-1.4	1.0
Chronic bronchitis/emphysema (father)	0.9	1.0	1.9	-1.0	-1.4	0.6
Neuroticism score	0.9	1.9	5.3	2.3	0.5	0.2
Number of live births	0.9	1.2	2.0	-1.4	-0.0	-1.3
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.8	2.0	-0.5	1.4
Medication: Lansoprazole	0.9	1.0	2.2	1.5	0.9	0.2
Illnesses of mother	0.9	1.1	2.4	-1.6	-0.9	-0.4
Pulse wave Arterial Stiffness index	0.9	1.0	2.5	-1.6	-0.6	0.3
Gout (self-reported)	0.9	1.2	2.5	0.9	1.6	-0.6
Migraine (self-reported)	0.9	1.2	2.5	-0.7	1.6	-0.7
Chest pain or discomfort	0.9	1.2	2.1	0.3	-1.4	1.2
Knee pain experienced in last month	0.9	1.4	2.4	-1.5	-1.1	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.7	1.1	1.3	0.1
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.4	0.3	1.5	-0.9
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.5	-1.0	-1.6	0.2
Blood Red Count	0.8	7.5	8.7	2.3	-3.0	2.9
Diabetes (father)	0.8	1.0	1.8	-0.3	1.4	-1.0
Supplements: Glucosamine	0.8	1.1	1.3	-1.0	1.1	-0.9
Heart attack	0.8	1.1	2.5	-0.8	-1.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.6	1.3	-0.5	0.9
Number of children fathered	0.8	0.9	1.6	-0.1	-1.3	1.0
Age at first live birth	0.8	1.4	3.0	0.5	1.7	-1.0
Diabetes diagnosed by doctor	0.8	1.3	3.1	1.8	0.7	0.7
Commuting to job workplace: Public transport	0.8	0.9	2.3	0.3	0.6	-1.5
Medication: Paracetamol	0.8	1.2	2.1	-0.7	1.0	-1.5
Vascular/heart problems diagnosed by doctor	0.8	2.1	5.5	-2.3	-0.6	-0.7
Ovarian Cancer	0.7	1.0	2.5	1.6	0.3	0.5
Triglycerides	0.7	1.1	1.7	1.2	-0.4	1.3
Lung FVC	0.7	3.6	6.0	-1.2	-2.4	1.9
Fed-up feelings	0.7	1.2	2.5	1.6	1.0	-0.3
Medication: Atenolol	0.7	0.8	1.3	0.6	0.9	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.9	0.8	0.9	-1.4
Birth weight	0.7	1.5	2.6	-0.3	-1.6	1.4
Shortness of breath walking on level ground	0.7	0.8	2.0	-0.6	-1.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.6	0.9	0.3	-1.3
Long-standing illness, disability or infirmity	0.7	1.0	1.6	1.2	1.1	-0.3
Miserableness	0.7	1.2	2.3	1.5	-0.4	1.1
Unable to work because of sickness or disability	0.7	0.9	1.5	-1.2	-0.3	-1.1
Cholesterol lowering medication	0.7	1.1	1.7	0.6	-1.1	1.3
Pain experienced in last month	0.7	1.1	1.5	-0.7	-1.2	1.2
Heart disease (siblings)	0.7	0.8	1.6	0.9	-0.3	1.3
Intelligence (Savage-Jansen 2018)	0.6	1.7	2.8	1.7	0.2	1.5
Medication: Co-codamol	0.6	0.7	1.5	-1.2	-0.3	-0.6
Hearing difficulty/problems with background noise	0.6	1.0	2.2	-1.5	-0.1	-1.0
Diabetes (self-reported)	0.6	1.0	1.9	0.9	1.4	-0.4
Pulse rate	0.6	1.0	1.1	0.9	1.0	-1.1
Noisy workplace	0.6	0.8	1.1	0.6	-0.9	1.0
Asthma	0.6	1.2	2.5	-1.6	-0.3	-1.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.6	-1.1	-1.3	0.3
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.9	0.2	0.1	1.4
Exposure to tobacco smoke outside home	0.6	0.8	1.3	-0.3	1.1	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.2	1.5	0.5	-0.2
Alcohol intake frequency.	0.6	1.4	1.7	-1.0	-1.2	1.3
Hypertension (Self-reported)	0.6	1.7	4.2	2.1	0.7	0.7
Illnesses of siblings: Diabetes	0.6	0.8	1.7	0.1	0.7	-1.3
Friendships satisfaction	0.6	0.8	1.9	-0.0	0.6	-1.4
Back pain experienced in last month	0.6	0.9	2.0	0.5	-0.6	1.4
Asthma (self-reported)	0.6	1.1	2.2	-1.5	0.0	-1.0
Medication: Bendroflumethiazide	0.6	0.9	1.3	1.2	0.7	1.0
Ever smoked	0.6	1.0	1.8	-1.3	-0.1	-1.1
Pack years of smoking	0.6	0.8	1.7	-0.9	0.1	-1.3
Depressed Affect (Nagel 2018)	0.5	1.1	1.9	1.4	0.9	-0.7
Schizophrenia vs Biploar Disorder	0.5	0.7	1.0	1.0	0.4	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.1	1.4	-0.1	1.2
Respiratory disease	0.5	1.1	2.0	-1.1	0.6	-1.4
Angina	0.5	0.7	1.2	0.7	-1.1	0.7
Pack years adult smoking proportion	0.5	0.7	1.4	-0.9	-0.1	-1.2
Medication: Simvastatin	0.5	0.7	1.4	0.7	-0.1	1.2
Fluid intelligence score	0.5	1.0	2.1	0.9	-0.1	1.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	1.2	0.3	0.2
Pulse rate, automated reading	0.5	1.5	2.0	1.4	1.4	-0.6
Number of full sisters	0.5	0.6	1.0	-1.0	-0.7	-0.4
Financial situation satisfaction	0.5	0.6	1.7	0.2	0.2	-1.3
Average weekly beer plus cider intake	0.5	0.7	1.8	-0.4	1.3	-0.5
Alzheimer’s Disease (in father)	0.4	0.5	1.3	0.3	1.1	0.1
Schizophrenia (2014)	0.4	1.0	2.7	-1.6	0.5	-0.3
Chronotype (morning person)	0.4	0.8	1.7	1.3	0.1	0.9
Number of treatments/medications taken	0.4	0.7	1.1	-0.1	1.0	-1.0
Relative age of first facial hair	0.4	0.7	2.1	-1.4	0.3	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.7	0.3	-1.3	0.4
Number of full brothers	0.4	0.5	1.0	-0.4	0.5	-1.0
Wheeze or whistling in the chest in last year	0.4	0.8	1.1	-0.5	1.0	-1.0
Medication: Blood pressure	0.4	0.7	1.1	1.0	1.0	-0.2
Angina (self-reported)	0.4	0.6	0.8	0.8	-0.9	0.6
Medication: Omeprazole	0.4	0.5	1.2	-1.1	-0.5	0.1
Medication: Seretide 50 evohaler	0.4	0.4	0.7	-0.8	0.8	-0.1
Overall health rating	0.4	0.9	1.2	-1.1	-0.7	-0.9
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.2	0.3	1.1	-0.1
Qualifications: nursing, teaching	0.4	0.6	0.8	0.6	-0.9	0.8
Illnesses of father: None of the above (group 1)	0.4	0.4	0.7	0.9	-0.6	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	-0.6	0.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	-1.0	-0.5	0.4
Reaction Time	0.3	0.5	1.4	0.5	-1.2	-0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	1.0	0.4	-0.1
Maternal smoking around birth	0.3	0.4	1.1	-0.1	-1.1	-0.3
Age when periods started (menarche)	0.3	0.7	1.9	1.4	0.2	-0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	0.2	-0.4	0.8
Past tobacco smoking	0.3	0.6	0.8	0.9	0.6	0.7
Alcohol usually taken with meals	0.3	0.4	1.0	-0.2	1.0	-0.4
Financial difficulties in last 2 years	0.3	0.4	0.5	-0.5	0.7	-0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.3	0.9	-0.5
Tense / ‘highly strung’	0.3	0.5	0.9	1.0	0.7	-0.4
Pulse wave reflection index	0.3	0.3	0.5	-0.7	-0.4	0.7
Eye problems/disorders: None of the above	0.3	0.3	0.8	-0.4	0.1	-0.9
Medication for pain relief, constipation, heartburn	0.3	0.5	1.3	0.2	-0.4	1.2
Had major operations	0.3	0.3	0.5	-0.7	-0.3	-0.7
Ever had bowel cancer screening	0.3	0.3	0.8	0.9	0.0	0.3
Number of self-reported non-cancer illnesses	0.3	0.4	0.7	-0.9	0.7	-0.4
Ever taken oral contraceptive pill	0.3	0.3	0.8	-0.0	-0.4	0.9
Diastolic blood pressure, automated reading	0.3	1.0	1.4	0.4	1.1	-1.2
Ever depressed for a whole week	0.3	0.4	0.4	-0.7	-0.6	0.5
Schizophrenia (2018)	0.2	0.5	1.3	-1.1	0.3	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.5	0.4	0.7	0.0
Smoking Status	0.2	0.4	1.2	-0.1	-1.1	0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.6	0.0	-0.8	0.5
Medication for hormone replacement therapy	0.2	0.2	0.5	0.7	0.4	-0.2
Medication: Metformin	0.2	0.3	0.8	-0.1	-0.3	0.9
Taking other prescription medications	0.2	0.3	0.6	-0.5	0.2	-0.8
Qualifications: CSEs or equivalent	0.2	0.3	0.8	-0.9	-0.3	-0.2
Stomach or abdominal pain in last month	0.2	0.2	0.5	0.7	-0.1	0.4
Medication: Levothyroxine sodium	0.2	0.4	0.8	-0.9	-0.4	0.3
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	-0.6	0.1	-0.6
Had other major operations	0.2	0.3	0.7	0.1	-0.8	0.4
Father’s age at death	0.2	0.2	0.6	-0.8	-0.1	0.0
Happiness	0.2	0.2	0.5	-0.2	0.4	-0.7
Pulse wave peak to peak time	0.2	0.2	0.5	0.7	0.2	-0.2
Qualifications: College or University degree	0.2	0.7	1.9	0.3	-0.3	1.4
Mean time to correctly identify matches	0.2	0.4	0.9	-0.3	-0.4	-0.9
Suffer from ‘nerves’	0.2	0.3	0.7	0.8	-0.0	-0.3
Smoking status: Previous	0.2	0.3	0.7	0.0	-0.8	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.4	0.6	0.6	0.0
Commuting to job workplace: Walk	0.2	0.3	0.5	-0.7	-0.4	-0.4
Eye problems/disorders: Cataract	0.2	0.2	0.5	-0.7	0.2	0.2
Medication: Gliclazide	0.2	0.2	0.3	0.3	0.6	0.6
Average weekly champagne plus white wine intake	0.2	0.3	0.8	0.2	0.9	-0.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	-0.7	-0.5	-0.0
Medication: Lisinopril	0.2	0.3	0.5	0.6	0.1	-0.7
Medication: Atorvastatin	0.2	0.2	0.4	0.6	-0.3	0.4
Irritability	0.2	0.3	0.8	0.9	-0.3	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.2	-0.8	0.3
Myopia	0.2	0.4	0.7	-0.3	0.5	-0.8
Depression (Nagel 2018)	0.1	0.2	0.5	0.1	-0.1	-0.7
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	0.7	-0.4	0.1
Ulcerative Colitis (UC)	0.1	0.2	0.6	0.8	-0.2	0.1
LDL Cholesterol	0.1	0.2	0.4	0.6	0.2	0.5
Ulcerative Colitis	0.1	0.2	0.2	0.5	-0.2	0.4
Hair Pigment	0.1	1.5	4.3	2.1	0.3	-0.1
Hand grip strength (left)	0.1	0.4	0.7	-0.8	0.3	-0.5
Hand grip strength (right)	0.1	0.4	0.7	-0.8	-0.5	0.5
Current tobacco smoking	0.1	0.2	0.6	-0.8	0.1	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	0.3	0.2	-0.6
Relative age voice broke	0.1	0.1	0.2	-0.4	0.2	0.5
High blood pressure (mother)	0.1	0.1	0.2	-0.5	-0.1	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.6	-0.4	-0.3
Mouth/teeth dental problems	0.1	0.2	0.4	-0.3	0.3	0.6
Prospective memory result	0.1	0.1	0.2	-0.3	0.1	-0.5
Lung cancer (father)	0.1	0.2	0.2	-0.5	-0.2	0.4
Loud music exposure frequency	0.1	0.1	0.4	-0.1	0.2	-0.6
Headache pain in last month	0.1	0.1	0.3	0.2	0.1	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.4	-0.4	-0.6	0.1
Family relationship satisfaction	0.1	0.1	0.2	0.0	-0.4	-0.3
Average weekly red wine intake	0.1	0.1	0.3	-0.6	0.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.3	0.4	-0.1
Osteoporosis (self-reported)	0.1	0.1	0.2	0.4	0.2	-0.3
Smoking status: Current	0.1	0.2	0.5	-0.7	0.3	-0.3
Mother’s age at death	0.1	0.1	0.3	0.5	0.4	0.0
Crohns Disease (2017)	0.0	0.1	0.2	0.1	-0.2	-0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.0	-0.3	0.0
Crohns Disease (2012)	0.0	0.1	0.1	0.0	-0.3	0.4
Tanning	0.0	0.5	1.3	-1.2	-0.3	-0.3
Multivitamins +/- minerals	0.0	0.1	0.1	-0.2	0.3	-0.2
Ever unenthusiastic/disinterested for a whole week	0.0	0.1	0.1	-0.2	-0.2	0.3
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	0.0	0.2	-0.1
Medication: Cholesterol lowering	0.0	0.0	0.0	-0.1	0.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	0.0	0.1	-0.0
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.0	-0.1	0.1
Illnesses of father: Heart disease	0.0	0.0	0.1	-0.1	0.3	0.1
High cholesterol (Self-reported)	0.0	0.0	0.1	-0.3	-0.0	-0.2

Hub : Genes

NUDT3

Models

Trait associations