TWAS hub - PACSIN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0710	0.0310	0.00170	0.013	0.018	0.016	0.020	0.021	0.0094	0.00240	0.0037	0.00160	0.0011
2	ROSMAP	Brain Pre-frontal Cortex	0.0946	0.0353	0.00024	0.001	0.023	0.016	0.023	0.004	0.2600	0.00045	0.0029	0.00048	0.0800

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Arm fat-free mass (right)	46.0	235.7	246.5	15.7	15.0
Arm predicted mass (right)	45.5	232.6	240.2	15.5	15.0
Arm fat-free mass (left)	44.4	225.1	234.1	15.3	14.7
Basal metabolic rate	44.3	245.1	259.2	16.1	15.2
Arm predicted mass (left)	44.3	225.2	237.2	15.4	14.6
Whole body fat-free mass	44.0	251.3	262.4	16.2	15.5
Whole body water mass	44.0	251.3	259.2	16.1	15.6
Trunk fat-free mass	43.5	249.6	249.6	15.8	15.8
Trunk predicted mass	43.4	248.1	249.6	15.8	15.7
Leg fat-free mass (left)	39.8	210.7	231.0	15.2	13.8
Leg predicted mass (left)	39.5	209.4	229.0	15.1	13.8
Leg predicted mass (right)	39.1	208.7	227.6	15.1	13.8
Leg fat-free mass (right)	38.9	207.8	228.0	15.1	13.7
Weight	38.4	188.9	219.0	14.8	12.6
Hip circumference	36.9	159.1	190.4	13.8	11.3
Height	30.6	588.9	676.0	22.4	26.0
Standing height	27.8	276.0	324.0	15.1	18.0
Leg fat mass (right)	21.6	83.8	112.4	10.6	7.4
Trunk fat mass	21.5	92.4	116.6	10.8	8.2
Leg fat mass (left)	21.5	83.8	112.4	10.6	7.4
Arm fat mass (left)	21.4	87.9	116.6	10.8	7.7
Whole body fat mass	21.1	87.9	114.5	10.7	7.8
Arm fat mass (right)	19.1	78.7	104.0	10.2	7.3
Waist circumference	18.6	68.2	86.3	9.3	7.1
Sitting height	18.5	131.5	146.4	10.8	12.1
Comparative height size at age 10	17.9	98.3	110.2	9.3	10.5
Forced expiratory volume in 1-second (FEV1), predicted	15.5	32.2	40.5	4.9	6.4
Blood Platelet Count	13.5	156.3	161.3	-12.7	-12.3
BMI	12.8	74.2	110.2	10.5	6.2
Forced expiratory volume in 1-second (FEV1)	12.0	40.4	57.5	4.8	7.6
Body mass index (BMI)	11.7	49.8	74.3	8.6	5.0
Allergy or Eczema	11.6	30.5	35.2	-5.9	-5.1
Forced vital capacity (FVC)	11.4	44.1	65.0	4.8	8.1
Hayfever, allergic rhinitis or eczema	10.4	22.6	27.3	-5.2	-4.2
Forced expiratory volume in 1-second (FEV1), Best measure	10.0	31.9	45.7	4.2	6.8
Medication: Omeprazole	9.4	11.2	15.5	3.9	2.6
Forced vital capacity (FVC), Best measure	9.1	33.3	49.0	4.2	7.0
Trunk fat percentage	8.9	35.8	51.0	7.1	4.5
HDL Cholesterol	8.8	14.7	20.2	-4.5	-3.0
Impedance of leg (left)	8.8	42.5	58.0	-7.6	-5.2
Number of operations (self-reported)	8.8	13.0	14.5	3.8	3.4
Impedance of whole body	8.8	44.8	59.6	-7.7	-5.5
Impedance of leg (right)	8.6	41.5	57.2	-7.6	-5.1
Bipolar Disorder (2011)	8.4	8.1	13.5	1.7	3.7
Impedance of arm (right)	8.4	39.1	51.1	-7.1	-5.2
Body fat percentage	8.2	32.3	49.0	7.0	4.0
Leg pain on walking	8.1	10.1	10.6	3.1	3.3
LDL Cholesterol	7.8	12.3	12.4	-3.5	-3.5
Body Mass Index (BMI) (2010)	7.7	10.6	12.6	3.5	2.9
Heart attack	7.7	9.9	10.1	3.2	3.1
Heart attack/myocardial infarction (self-reported)	7.7	10.0	10.0	3.2	3.2
Medication: Omeprazole (e.g. Zanprol)	7.5	9.1	12.5	3.5	2.4
Exposure to tobacco smoke at home	7.3	8.2	8.6	2.9	2.8
Arm fat percentage (left)	7.3	28.9	46.5	6.8	3.4
Leg fat percentage (right)	7.2	26.1	42.0	6.5	3.2
Overall health rating	7.0	15.1	16.8	4.1	3.7
Leg fat percentage (left)	7.0	25.4	41.5	6.4	3.1
Allergy	6.9	15.9	16.8	4.1	3.9
Waist Hip Ratio (WHR)	6.8	30.6	45.7	-6.8	-3.9
Impedance of arm (left)	6.8	31.4	42.4	-6.5	-4.5
Shortness of breath walking on level ground	6.6	7.8	8.1	2.7	2.9
Worry (Nagel 2018)	6.5	13.7	18.5	-4.3	-3.0
Myopia	6.3	9.1	10.8	-2.7	-3.3
Neuroticism (Nagel 2018)	6.2	14.5	15.8	-4.0	-3.6
Arm fat percentage (right)	6.2	24.5	40.7	6.4	2.9
Health satisfaction	5.8	7.6	8.0	2.7	2.8
Nervous feelings	5.7	10.6	14.1	-3.8	-2.7
Relative age of first facial hair	5.5	11.3	14.1	2.9	3.8
Worrier / anxious feelings	5.5	10.4	12.4	-3.5	-2.9
Bipolar Disorder or Schizophrenia	5.4	13.2	18.6	2.8	4.3
Hand grip strength (right)	5.0	13.7	18.2	3.0	4.3
Pulse rate, automated reading	5.0	16.2	21.3	-4.6	-3.3
Unable to work because of sickness or disability	4.9	6.4	8.0	2.8	2.2
Back pain experienced in last month	4.8	7.0	11.0	3.3	1.8
Smoking Status	4.7	11.2	13.7	3.7	3.0
Chest pain or discomfort	4.7	6.7	8.1	2.9	2.3
Length of working week for main job	4.6	5.1	5.6	2.4	2.1
Peak expiratory flow (PEF)	4.5	10.4	12.0	2.9	3.5
Worry too long after embarrassment	4.3	7.2	9.6	-2.2	-3.1
Schizophrenia (2018)	4.1	8.5	10.4	2.6	3.2
Coronary Artery Disease (CAD)	4.1	4.9	7.8	2.8	1.4
Townsend deprivation index at recruitment	4.1	5.8	7.6	2.0	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	3.9	5.9	6.2	-2.5	-2.4
Guilty feelings	3.9	5.9	7.2	-2.1	-2.7
Schizophrenia (2014)	3.7	8.1	10.3	2.4	3.2
Blood Eosinophil Count	3.7	28.6	41.6	-4.0	-6.5
Blood White Count	3.7	27.5	33.1	-4.7	-5.8
Illnesses of siblings: Diabetes	3.7	4.5	5.0	2.0	2.2
Bipolar Disorder (2018)	3.6	5.6	8.6	1.6	2.9
Hand grip strength (left)	3.6	9.4	13.9	2.2	3.7
Pain type(s) experienced in last month: Hip pain	3.6	4.6	4.8	2.2	2.1
Exposure to tobacco smoke outside home	3.5	4.7	4.9	2.1	2.2
Pulse wave Arterial Stiffness index	3.4	4.0	5.7	2.4	1.5
Ever unenthusiastic/disinterested for a whole week	3.3	4.0	4.6	-2.2	-1.8
Medication for cholesterol	3.2	4.8	7.4	-2.7	-1.5
Neuroticism (2016)	3.0	4.3	5.7	-1.7	-2.4
Long-standing illness, disability or infirmity	3.0	4.6	8.5	2.9	0.8
Neuroticism	2.9	7.0	10.8	-1.8	-3.3
Medication: Co-codamol	2.9	3.3	5.3	2.3	1.1
Fed-up feelings	2.9	5.2	6.4	-2.0	-2.5
Had other major operations	2.9	3.5	4.2	2.0	1.7
Knee pain experienced in last month	2.9	4.5	6.0	2.5	1.7
Ever had hysterectomy (womb removed)	2.8	3.2	3.3	1.8	1.8
Smoking status: Current	2.8	4.5	6.3	2.5	1.6
Crohns Disease (2012)	2.7	4.3	6.2	-1.5	-2.5
Heel bone mineral density (BMD) T-score, automated (left)	2.6	5.9	9.8	-1.4	-3.1
Medication: Ventolin 100micrograms inhaler	2.6	3.4	6.0	-0.9	-2.4
Ever depressed for a whole week	2.6	3.2	3.8	-2.0	-1.6
Age at First Birth	2.5	3.7	3.7	-1.9	-1.9
Medication for pain relief, constipation, heartburn	2.5	4.2	7.8	-2.8	-0.8
Current tobacco smoking	2.4	3.9	5.8	2.4	1.4
Hearing difficulty/problems with background noise	2.4	3.8	5.3	1.6	2.3
Medication: Ramipril	2.4	3.1	3.7	1.9	1.6
Frequency of tiredness / lethargy in last 2 weeks	2.4	4.0	4.9	2.2	1.7
Ovarian Cancer	2.3	3.1	4.4	-1.3	-2.1
Sensitivity / hurt feelings	2.3	3.9	5.5	-1.5	-2.3
Prospective memory result	2.3	2.8	2.9	-1.7	-1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	4.7	2.2	0.8
Systolic Blood Pressure	2.2	11.0	13.7	-3.7	-2.9
Lung FEV1/FVC ratio	2.2	11.1	11.8	3.4	3.2
Hair/balding pattern: Pattern 4	2.2	5.4	6.3	-2.1	-2.5
Tinnitus: Yes, now most or all of the time	2.2	2.6	3.2	1.8	1.4
Ever had prostate specific antigen (PSA) test	2.2	2.6	3.8	1.9	1.2
Maternal smoking around birth	2.1	3.0	5.0	2.2	1.0
Stomach or abdominal pain in last month	2.1	2.6	3.5	1.3	1.9
Gout (self-reported)	2.1	2.9	4.2	-2.1	-1.2
Fractured/broken bones in last 5 years	2.1	2.7	5.0	2.2	0.6
Average weekly spirits intake	2.0	2.4	4.7	2.2	0.4
Average weekly fortified wine intake	2.0	2.3	3.2	-1.2	-1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	3.1	-1.4	-1.8
Age at first live birth	2.0	3.6	6.1	-2.5	-1.0
Eye problems/disorders: None of the above	2.0	2.3	3.4	-1.8	-1.1
Supplements: Vitamin C	2.0	2.4	3.4	-1.2	-1.8
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	3.1	1.8	1.4
Emphysema/chronic bronchitis	1.9	2.2	2.9	1.7	1.2
Had major operations	1.9	2.2	3.1	1.8	1.1
Angina	1.8	2.4	2.6	1.6	1.5
Depression (self-reported)	1.8	2.2	2.9	-1.2	-1.7
Comparative body size at age 10	1.8	4.9	9.1	3.0	0.8
Average weekly red wine intake	1.8	2.7	5.0	0.6	2.2
Alzheimer’s Disease (in mother)	1.7	2.0	2.8	-1.1	-1.7
Alzheimer’s Disease (including proxy)	1.7	2.4	3.2	-1.3	-1.8
Ulcerative Colitis (UC)	1.7	3.1	4.2	-1.4	-2.0
Rheumatoid Arthritis	1.7	2.3	3.3	1.2	1.8
HbA1C	1.6	1.8	3.6	-0.3	-1.9
Systolic blood pressure, automated reading	1.6	4.6	7.6	-1.3	-2.8
Age when periods started (menarche)	1.6	3.9	5.6	2.4	1.5
Neuroticism score	1.6	3.3	4.3	-1.5	-2.1
Pulse rate	1.6	2.7	3.8	-2.0	-1.2
Angina (self-reported)	1.6	2.2	2.5	1.6	1.3
Commuting to job workplace: Car/motor vehicle	1.6	1.8	2.9	-0.9	-1.7
Medication: Blood pressure	1.6	3.0	5.5	2.4	0.7
Ever smoked	1.6	2.8	3.7	1.4	1.9
Cholesterol lowering medication	1.6	2.4	3.8	2.0	1.0
Irritable Bowel Disease (IBD)	1.5	3.6	5.3	-1.4	-2.3
Taking other prescription medications	1.5	2.2	3.9	2.0	0.7
Hair/balding pattern: Pattern 3	1.5	2.2	2.6	-1.6	-1.4
Pulse wave reflection index	1.5	1.8	2.5	1.6	1.1
Asthma (self-reported)	1.5	3.0	4.1	-1.4	-2.0
Illnesses of father: High blood pressure	1.5	1.9	2.7	-1.0	-1.6
Pain experienced in last month	1.5	2.4	4.5	-2.1	-0.7
Migraine (self-reported)	1.4	1.7	3.3	0.3	-1.8
Medication: Aspirin	1.4	1.9	3.7	1.9	0.2
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.0	1.4	0.9
Vitamin and mineral supplements	1.3	1.8	2.1	1.2	1.4
Diabetes (father)	1.3	1.7	2.5	-1.6	-0.9
Relative age voice broke	1.3	2.0	3.7	0.6	1.9
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.8	-0.7	-1.7
Medication: Allopurinol	1.3	1.8	2.1	-1.2	-1.4
Osteoarthritis (self-reported)	1.3	1.6	2.4	1.5	1.0
Number of treatments/medications taken	1.2	2.1	4.0	2.0	-0.5
Asthma	1.2	2.5	3.2	-1.3	-1.8
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.2	1.5	0.8
Number of full sisters	1.2	1.5	2.0	1.0	1.4
Alcohol drinker status: Previous	1.2	1.3	2.2	1.5	-0.6
Pain all over the body in last month	1.1	1.2	1.6	1.3	0.9
Birth weight of first child	1.1	2.0	2.4	-1.6	1.2
Medication: Amlodipine	1.1	1.5	3.0	0.0	-1.7
Age at last live birth	1.1	1.6	3.0	-1.7	-0.6
Hypertension (Self-reported)	1.1	3.0	5.8	2.4	0.4
Vascular/heart problems diagnosed by doctor	1.1	2.9	5.6	-2.4	-0.4
Depressed Affect (Nagel 2018)	1.0	2.0	3.3	-0.9	-1.8
Breast Cancer	1.0	2.5	2.7	1.5	1.6
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.1	1.4	0.6
Medication: Aspirin	1.0	1.3	2.5	1.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	4.2	-0.2	2.0
Depression (Nagel 2018)	0.9	1.3	1.8	-1.3	-1.0
Crohns Disease (2017)	0.9	1.9	3.1	-0.9	-1.8
Ulcerative Colitis	0.9	1.3	2.3	-0.5	-1.5
Cardiovascular Disease	0.9	3.0	5.7	2.4	0.5
Diabetes (mother)	0.9	1.1	1.9	1.4	0.6
Severe depression (siblings)	0.9	1.1	1.4	-1.2	-0.9
Past tobacco smoking	0.9	1.6	2.3	-0.9	-1.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.6	-1.3	-0.9
Ever taken oral contraceptive pill	0.9	1.0	1.3	-1.2	-0.9
Risk taking	0.9	1.3	2.1	1.5	0.7
Lupus	0.8	1.1	2.2	0.2	-1.5
Lung FVC	0.8	4.2	8.4	-2.9	0.1
Medication for hormone replacement therapy	0.8	0.9	0.9	1.0	1.0
High blood pressure	0.8	2.1	4.2	2.0	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.1	-0.8	-1.8
Alcohol intake versus 10 years previously	0.8	1.2	1.5	-0.9	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.4	1.2	0.6
Glaucoma (self-reported)	0.8	1.0	1.8	-0.3	-1.4
Mood swings	0.8	1.5	2.6	-0.6	-1.6
Alzheimer’s Disease (in father)	0.7	0.7	0.9	-0.7	-1.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.2	0.6	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	1.8	0.6	1.3
Qualifications: None of the above	0.7	1.5	2.0	-1.0	-1.4
Falls in the last year	0.7	1.0	1.4	0.8	1.2
Lung cancer (father)	0.7	0.8	1.3	1.1	0.6
Tense / ‘highly strung’	0.7	1.2	2.3	-1.5	-0.4
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	-1.2	-0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.6	1.3	0.2
Wheeze or whistling in the chest in last year	0.7	1.3	1.8	-0.9	-1.3
Number of children fathered	0.7	0.8	1.2	1.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.5	-1.2	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.7	1.3	0.0
Breast cancer (self-reported)	0.7	0.8	1.5	-1.2	-0.3
Average weekly beer plus cider intake	0.7	1.0	1.1	-1.0	-1.0
Fasting Glucose	0.6	0.7	1.2	1.1	-0.5
Supplements: Zinc	0.6	0.7	1.0	1.0	0.6
Mouth/teeth dental problems: Dentures	0.6	1.0	1.4	1.2	0.8
Pulse wave peak to peak time	0.6	0.7	1.4	-1.2	-0.3
Eye problems/disorders: Cataract	0.6	0.6	1.2	1.1	0.4
Number of self-reported non-cancer illnesses	0.6	1.0	2.0	1.4	0.2
Wears glasses or contact lenses	0.6	0.7	0.8	0.9	0.8
Medication: Bendroflumethiazide	0.6	0.9	1.8	1.4	0.1
Commuting to job workplace: Cycle	0.6	0.7	1.4	-1.2	0.1
Medication: Levothyroxine sodium	0.5	0.9	1.3	1.1	-0.7
Happiness	0.5	0.6	0.7	-0.8	0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.2	2.4	-1.5	-0.2
Blood clot in the leg (DVT)	0.5	0.6	1.1	1.1	0.3
Headache pain in last month	0.5	0.8	1.6	1.2	0.1
Neck or shoulder pain in last month	0.5	0.7	1.2	1.1	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	0.4	1.0
Friendships satisfaction	0.5	0.6	1.1	-1.1	-0.1
Medication: Lisinopril	0.5	0.6	1.1	1.1	-0.3
Heart disease (siblings)	0.5	0.6	0.7	0.9	0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	0.9	0.5
Multivitamins +/- minerals	0.4	0.6	0.8	-0.9	-0.6
High blood pressure (mother)	0.4	0.6	1.1	0.1	1.1
Hair/balding pattern: Pattern 2	0.4	0.5	0.5	0.7	0.7
Financial difficulties in last 2 years	0.4	0.5	0.8	0.5	-0.9
Medication: Simvastatin	0.4	0.6	1.0	-0.3	-1.0
Fluid intelligence score	0.4	0.9	1.6	0.5	-1.3
Birth weight	0.4	0.8	1.5	-1.2	0.4
Heart disease (mother)	0.4	0.5	1.0	1.0	0.3
Illnesses of father: Heart disease	0.4	0.5	0.7	0.6	0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.7	-0.5	-0.8
Loneliness, isolation	0.4	0.5	0.9	0.5	-0.9
Medication: Gliclazide	0.4	0.5	0.9	0.1	1.0
Hearing aid user	0.4	0.5	0.7	-0.5	0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	1.0	0.3
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.8	-0.2	-1.4
Major Depression (MDD)	0.3	0.4	0.7	-0.4	-0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.7	-0.1	0.9
Heel T-Score	0.3	2.5	3.1	-1.8	-1.4
Respiratory disease	0.3	0.6	0.9	-0.4	-1.0
Chronotype (morning person)	0.3	0.7	1.2	-0.3	-1.1
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	-0.9	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.6	-0.8	-0.3
Illnesses of mother	0.3	0.4	0.5	-0.5	0.7
Breastfed as a baby	0.3	0.4	0.4	0.6	0.7
Loud music exposure frequency	0.3	0.4	0.4	-0.6	0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	0.2	0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.0	0.0	1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.2	1.1	0.4
Medication: Blood pressure	0.3	0.5	0.9	0.2	-0.9
Suffer from ‘nerves’	0.3	0.5	1.0	-1.0	0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.7	-0.5	-0.9
Illnesses of father: None of the above (group 1)	0.3	0.3	0.7	0.8	-0.0
Average weekly champagne plus white wine intake	0.3	0.4	0.6	-0.8	-0.4
Commuting to job workplace: Public transport	0.3	0.3	0.6	0.3	0.8
Medication: Paracetamol	0.3	0.4	0.8	0.9	-0.3
Diastolic blood pressure, automated reading	0.3	1.1	2.1	1.5	-0.1
Pack years of smoking	0.3	0.5	0.9	1.0	0.0
Triglycerides	0.2	0.3	0.5	0.7	0.4
Blood Red Count	0.2	2.0	2.7	-1.6	-1.1
Pack years adult smoking proportion	0.2	0.2	0.5	0.7	-0.1
Supplements: Glucosamine	0.2	0.2	0.4	-0.2	0.6
Number of incorrect matches in round	0.2	0.3	0.5	0.3	0.7
Alcohol usually taken with meals	0.2	0.4	0.7	-0.8	-0.2
Mouth/teeth dental problems	0.2	0.3	0.6	0.2	0.8
Time employed in main current job	0.2	0.2	0.3	-0.5	-0.5
Medication: Paracetamol	0.2	0.3	0.5	0.4	-0.7
High blood pressure (siblings)	0.2	0.3	0.4	0.5	0.6
Mean time to correctly identify matches	0.2	0.4	0.5	0.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.7	0.0
Ever had bowel cancer screening	0.2	0.2	0.4	0.6	0.2
Diabetes diagnosed by doctor	0.2	0.3	0.5	-0.7	-0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.3	-0.5	-0.5
Alcohol drinker status: Never	0.2	0.3	0.3	0.5	0.6
Supplements: Calcium	0.2	0.2	0.3	-0.3	-0.6
Reaction Time	0.1	0.1	0.2	0.5	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.3	-0.6
Hypothyroidism (self reported)	0.1	0.3	0.5	0.7	-0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	-0.3	0.4
Hair Pigment	0.1	4.0	4.3	1.9	2.1
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.1	0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.1	0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.2	0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.4	0.3
Medication: Atenolol	0.1	0.2	0.4	0.6	-0.0
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.4	0.4
Diabetes (self-reported)	0.1	0.2	0.2	-0.4	-0.4
Illnesses of siblings	0.1	0.1	0.2	0.5	0.2
Father’s age at death	0.1	0.1	0.1	0.2	-0.3
Number of live births	0.1	0.1	0.2	0.3	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	0.2	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.5	-0.1
Alcohol intake frequency.	0.1	0.1	0.1	0.4	-0.4
Family relationship satisfaction	0.1	0.1	0.1	-0.4	0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.2	0.6
Smoking status: Previous	0.1	0.2	0.4	0.0	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.2	-0.5
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.0	0.5
Commuting to job workplace: Walk	0.1	0.2	0.2	0.4	0.4
Mineral and other dietary supplements	0.1	0.1	0.1	-0.4	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	0.4	-0.2
High cholesterol (Self-reported)	0.1	0.1	0.2	0.5	-0.2
Medication: Atorvastatin	0.1	0.1	0.2	0.4	0.2
Irritability	0.1	0.2	0.3	-0.5	-0.5
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	0.4	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.1	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.1	0.3	-0.0
Primary Biliary Cirrhosis	0.0	0.0	0.0	-0.2	0.2
Tanning	0.0	0.3	0.4	-0.5	-0.7
Medication: Metformin	0.0	0.0	0.0	-0.1	0.1
Had menopause	0.0	0.0	0.0	0.1	0.1
Noisy workplace	0.0	0.1	0.1	-0.3	-0.1
Medication: Cholesterol lowering	0.0	0.0	0.0	0.0	-0.0
Medication: Lansoprazole	0.0	0.0	0.1	0.3	-0.1
Number of full brothers	0.0	0.0	0.0	0.0	-0.1
Qualifications: College or University degree	0.0	0.1	0.2	0.4	0.3
Medication: Ibuprofen	0.0	0.0	0.1	0.3	-0.2
Osteoporosis (self-reported)	0.0	0.0	0.1	0.2	-0.2
Miserableness	0.0	0.1	0.2	0.1	0.4
Mother’s age at death	0.0	0.0	0.1	-0.2	-0.1
Financial situation satisfaction	0.0	0.0	0.1	0.0	0.2
Age started oral contraceptive pill	0.0	0.0	0.0	0.2	-0.1

Hub : Genes

PACSIN1

Models

Trait associations