Best TWAS P=9.32e-11 · Best GWAS P=1.38e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HEY2 | 0.15 | 0.20 | lasso | 10 | 0.21 | 6.7e-25 | 6.4 | 6.4 | 1.9e-10 | 1.00 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | HINT3 | 0.39 | -0.01 | enet | 16 | 0.08 | 2.2e-03 | 3.7 | 5.3 | 1.1e-07 | 0.38 | 0.12 | 0.11 | FALSE |
| 3 | GTEx | Esophagus Muscularis | HINT3 | 0.08 | 0.00 | enet | 14 | 0.00 | 2.9e-01 | -6.3 | 5.3 | 1.4e-07 | 0.78 | 0.03 | 0.66 | FALSE |
| 4 | GTEx | Pancreas | HEY2 | 0.28 | 0.11 | lasso | 3 | 0.10 | 3.5e-05 | 5.0 | 5.4 | 5.9e-08 | 0.88 | 0.11 | 0.89 | FALSE |
| 5 | GTEx | Testis | HEY2 | 0.31 | 0.17 | lasso | 5 | 0.19 | 7.4e-09 | 6.4 | 6.5 | 9.9e-11 | 0.97 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Thyroid | HEY2 | 0.22 | 0.24 | lasso | 6 | 0.23 | 1.0e-17 | 6.4 | 6.5 | 9.3e-11 | 0.96 | 0.01 | 0.99 | TRUE |
| 7 | METSIM | Adipose | NCOA7 | 0.05 | 0.05 | enet | 5 | 0.05 | 1.9e-07 | -5.2 | -5.7 | 1.3e-08 | -0.66 | 0.85 | 0.13 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | HEY2 | 0.10 | 0.12 | enet | 15 | 0.13 | 9.8e-17 | -6.1 | 6.1 | 1.1e-09 | 0.95 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | HEY2 | 0.03 | 0.04 | lasso | 3 | 0.02 | 3.8e-03 | -6.0 | 6.1 | 9.0e-10 | 0.91 | 0.01 | 0.97 | FALSE |