[Hub]/) : Traits : Impedance of leg (left) :

chr11:26,814,230-29,054,545

Best TWAS P=5.04e-12 · Best GWAS P=2.65e-26 conditioned to 6.49e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous LIN7C 0.08 0.06 lasso 1 0.04 4.1e-04 -5.8 -5.8 6.5e-09 -0.26 0.86 0.00 FALSE
2 GTEx Nerve Tibial LIN7C 0.18 0.08 enet 27 0.12 4.2e-09 -5.8 -5.5 3.0e-08 -0.02 0.95 0.00 FALSE
3 GTEx Thyroid LIN7C 0.08 0.04 lasso 4 0.04 6.0e-04 -5.8 -5.7 1.1e-08 -0.14 0.81 0.01 TRUE
4 NTR Blood LIN7C 0.01 0.00 lasso 3 0.01 2.2e-03 -6.6 6.2 7.3e-10 0.17 0.52 0.01 FALSE
5 ROSMAP Brain Pre-frontal Cortex METTL15 0.04 0.03 blup 364 0.03 4.6e-05 2.4 5.5 3.3e-08 0.26 0.70 0.04 TRUE
6 The Cancer Genome Atlas Breast Invasive Carcinoma BBOX1 0.03 0.00 blup 90 0.01 8.9e-04 -6.1 -6.0 1.5e-09 0.07 0.03 0.46 FALSE
7 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma BBOX1 0.10 0.00 blup 90 0.05 1.3e-03 5.1 -6.7 2.3e-11 0.10 0.01 0.88 FALSE
8 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LIN7C 0.05 0.02 lasso 3 0.03 2.9e-04 -5.9 -5.2 1.7e-07 -0.11 0.39 0.02 FALSE
9 The Cancer Genome Atlas Brain Lower Grade Glioma BBOX1 0.07 0.03 blup 90 0.04 4.8e-05 4.6 -5.8 5.8e-09 0.05 0.36 0.21 FALSE
10 The Cancer Genome Atlas Prostate Adenocarcinoma BDNFOS 0.03 0.01 blup 83 0.02 1.4e-03 1.0 -6.2 7.0e-10 -0.76 0.02 0.92 TRUE
11 The Cancer Genome Atlas Thyroid Carcinoma BBOX1 0.04 0.00 blup 90 0.03 1.3e-03 5.9 -6.9 5.0e-12 0.08 0.02 0.52 TRUE