Best TWAS P=5.04e-12 · Best GWAS P=2.65e-26 conditioned to 6.49e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LIN7C | 0.08 | 0.06 | lasso | 1 | 0.04 | 4.1e-04 | -5.8 | -5.8 | 6.5e-09 | -0.26 | 0.86 | 0.00 | FALSE |
| 2 | GTEx | Nerve Tibial | LIN7C | 0.18 | 0.08 | enet | 27 | 0.12 | 4.2e-09 | -5.8 | -5.5 | 3.0e-08 | -0.02 | 0.95 | 0.00 | FALSE |
| 3 | GTEx | Thyroid | LIN7C | 0.08 | 0.04 | lasso | 4 | 0.04 | 6.0e-04 | -5.8 | -5.7 | 1.1e-08 | -0.14 | 0.81 | 0.01 | TRUE |
| 4 | NTR | Blood | LIN7C | 0.01 | 0.00 | lasso | 3 | 0.01 | 2.2e-03 | -6.6 | 6.2 | 7.3e-10 | 0.17 | 0.52 | 0.01 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | METTL15 | 0.04 | 0.03 | blup | 364 | 0.03 | 4.6e-05 | 2.4 | 5.5 | 3.3e-08 | 0.26 | 0.70 | 0.04 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | BBOX1 | 0.03 | 0.00 | blup | 90 | 0.01 | 8.9e-04 | -6.1 | -6.0 | 1.5e-09 | 0.07 | 0.03 | 0.46 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | BBOX1 | 0.10 | 0.00 | blup | 90 | 0.05 | 1.3e-03 | 5.1 | -6.7 | 2.3e-11 | 0.10 | 0.01 | 0.88 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIN7C | 0.05 | 0.02 | lasso | 3 | 0.03 | 2.9e-04 | -5.9 | -5.2 | 1.7e-07 | -0.11 | 0.39 | 0.02 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BBOX1 | 0.07 | 0.03 | blup | 90 | 0.04 | 4.8e-05 | 4.6 | -5.8 | 5.8e-09 | 0.05 | 0.36 | 0.21 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BDNFOS | 0.03 | 0.01 | blup | 83 | 0.02 | 1.4e-03 | 1.0 | -6.2 | 7.0e-10 | -0.76 | 0.02 | 0.92 | TRUE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | BBOX1 | 0.04 | 0.00 | blup | 90 | 0.03 | 1.3e-03 | 5.9 | -6.9 | 5.0e-12 | 0.08 | 0.02 | 0.52 | TRUE |