TWAS hub - BBOX1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1500	0.0400	2.9e-05	0.055	0.021	0.039	0.045	0.067	2.5e-07	1.2e-03	1.5e-05	3.3e-06	1.3e-08
2	ROSMAP	Brain Pre-frontal Cortex	0.1155	0.0310	1.6e-06	0.027	0.053	0.055	0.020	0.053	1.7e-04	2.4e-07	1.2e-07	1.2e-03	2.3e-07
3	TCGA	Breast Invasive Carcinoma	0.0307	0.0157	4.9e-04	0.000	0.013	0.005	NA	0.008	3.1e-01	8.9e-04	3.0e-02	NA	5.9e-03
4	TCGA	Cervical Squamous Cell Carcinoma	0.0960	0.0450	9.6e-04	0.004	0.053	0.043	NA	0.029	2.0e-01	1.3e-03	3.6e-03	NA	1.3e-02
5	TCGA	Brain Lower Grade Glioma	0.0668	0.0318	2.0e-04	0.035	0.036	0.024	NA	0.026	7.6e-05	4.8e-05	9.3e-04	NA	4.8e-04
6	TCGA	Thyroid Carcinoma	0.0390	0.0200	4.3e-03	0.003	0.026	0.007	NA	0.019	1.7e-01	1.3e-03	6.3e-02	NA	5.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Impedance of leg (left)	6.4	31.1	47.7	-4.2	-2.6	-6.0	-6.7	-5.8	-6.9
Impedance of leg (right)	6.3	30.7	46.8	-3.9	-2.3	-6.4	-6.8	-5.5	-6.8
Hearing difficulty/problems with background noise	4.4	7.0	10.0	-2.1	-3.0	-2.7	-2.6	-2.2	-3.2
HbA1C	4.0	4.5	6.3	2.4	2.0	1.8	1.8	2.5	2.1
Breast Cancer	3.7	9.0	11.5	-2.6	-2.8	-2.9	-3.4	-3.0	-3.2
Fed-up feelings	3.6	6.5	10.4	-1.5	-3.2	-2.5	-2.5	-2.2	-2.9
Pain type(s) experienced in last month: Hip pain	3.6	4.5	9.1	-0.8	-1.6	-2.4	-2.5	-1.6	-3.0
Medication: Allopurinol	3.4	4.6	7.4	-1.8	-2.1	-2.6	-2.7	-1.5	-1.9
Handedness (chirality/laterality): Left-handed	3.0	3.6	5.4	-1.8	-1.5	-1.3	-2.1	-2.1	-2.3
Myopia	2.6	3.8	5.2	1.5	2.3	1.9	1.6	2.2	2.0
Gout (self-reported)	2.4	3.2	4.5	-1.2	-1.9	-2.1	-2.0	-1.5	-1.9
Eye problems/disorders: None of the above	2.4	2.8	5.4	-2.3	-2.3	-1.3	-0.3	-1.9	-0.9
Friendships satisfaction	2.4	2.9	6.4	-1.4	-2.5	-1.3	-1.9	-1.4	-1.5
Supplements: Zinc	2.3	2.5	3.6	1.7	1.6	1.4	0.7	1.9	1.8
Back pain experienced in last month	2.3	3.3	6.8	1.6	1.1	1.1	2.6	2.4	1.5
Neuroticism score	2.2	4.5	7.7	-1.6	-2.8	-1.9	-1.7	-1.9	-2.6
Mouth/teeth dental problems: Mouth ulcers	2.2	3.5	7.3	-1.0	-1.0	-1.7	-2.7	-2.1	-2.1
Supplements: Calcium	2.2	2.4	5.2	-0.4	-0.5	-1.2	-2.3	-1.4	-2.3
Impedance of whole body	2.2	11.1	17.1	-2.3	-0.6	-4.1	-3.7	-3.6	-4.1
Neuroticism (Nagel 2018)	2.1	5.0	8.0	-1.7	-2.8	-1.9	-2.3	-2.0	-2.4
Diabetes (self-reported)	2.1	3.2	6.8	1.5	1.1	2.6	2.0	1.5	1.8
Length of working week for main job	2.1	2.3	3.1	-1.6	-1.5	-1.8	-1.7	-0.9	-1.4
Wheeze or whistling in the chest in last year	2.1	3.7	8.4	2.9	1.4	1.6	0.6	2.5	1.6
Medication: Bendroflumethiazide	2.0	3.1	5.8	1.5	2.2	1.5	1.0	2.4	1.5
Coronary Artery Disease (CAD)	1.9	2.3	3.8	-1.2	-1.6	-1.4	-0.7	-1.8	-2.0
Medication for hormone replacement therapy	1.9	2.1	3.3	-1.3	-1.6	-1.3	-1.4	-1.8	-1.3
Medication: Metformin	1.9	2.7	3.7	1.8	1.4	1.9	1.8	1.1	1.7
Lung cancer (father)	1.9	2.3	5.8	-0.6	-1.1	-1.6	-0.9	-1.8	-2.4
Leg fat percentage (right)	1.9	6.7	12.7	-0.7	-2.6	-2.4	-3.6	-1.6	-3.5
Chronic bronchitis/emphysema (father)	1.8	2.1	4.7	-1.6	-1.4	-0.8	-0.9	-2.2	-1.6
Diabetes diagnosed by doctor	1.8	2.9	6.0	1.5	0.9	2.4	2.0	1.2	1.7
Commuting to job workplace: Public transport	1.8	2.2	5.8	1.8	2.4	1.3	1.0	1.0	0.7
Heel T-Score	1.7	13.2	44.6	-4.1	-6.7	-2.5	-1.7	-2.7	-1.0
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	4.0	-0.9	-1.2	-1.4	-2.0	-0.4	-1.6
Nervous feelings	1.7	3.2	5.0	-2.0	-1.2	-1.9	-1.5	-1.6	-2.2
Allergy	1.7	3.9	5.5	-2.4	-2.3	-2.0	-1.5	-1.9	-1.6
Depression (self-reported)	1.7	2.0	3.4	1.5	1.3	1.8	1.7	1.1	0.9
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	4.8	-2.2	-1.6	-0.4	-1.1	-1.7	-0.8
Supplements: Vitamin C	1.7	2.0	4.1	-1.0	-0.6	-0.7	-1.8	-2.0	-1.8
Leg fat percentage (left)	1.7	6.1	11.2	-0.6	-2.7	-1.9	-3.3	-1.7	-3.4
Worrier / anxious feelings	1.6	3.0	4.7	-1.5	-1.7	-1.4	-1.8	-1.6	-2.2
Depressed Affect (Nagel 2018)	1.5	3.1	9.5	-0.9	-3.1	-1.0	-1.4	-1.5	-1.8
Leg fat-free mass (right)	1.5	8.1	13.4	2.5	0.2	3.0	2.6	3.7	3.6
Leg predicted mass (right)	1.5	8.2	13.6	2.5	0.2	3.0	2.7	3.7	3.7
LDL Cholesterol	1.4	2.2	4.4	0.5	1.1	1.3	2.1	1.8	1.7
Neuroticism	1.4	3.3	5.7	-0.8	-2.4	-1.2	-1.5	-2.0	-2.3
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	6.2	-0.5	-2.5	-0.8	-1.0	-1.4	-1.8
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.1	1.1	1.2	1.2	1.3	1.4	1.4
Birth weight	1.4	3.1	5.2	-1.7	-2.3	-1.9	-1.2	-1.6	-1.8
Irritability	1.4	2.4	5.0	-0.7	-1.5	-1.2	-2.2	-1.3	-2.0
Ever had prostate specific antigen (PSA) test	1.4	1.7	3.5	1.1	1.9	1.0	1.1	0.9	1.5
Average weekly spirits intake	1.3	1.6	3.1	1.6	1.3	1.8	0.7	1.1	0.7
Sensitivity / hurt feelings	1.3	2.3	3.3	-1.3	-1.8	-1.5	-1.5	-1.3	-1.5
Severe depression (siblings)	1.3	1.4	2.8	0.5	0.5	1.7	0.5	1.7	1.5
Age at first live birth	1.3	2.4	3.7	-1.5	-1.0	-1.8	-1.3	-1.9	-1.5
Eye problems/disorders: Cataract	1.3	1.5	2.5	1.6	1.5	1.5	0.2	1.3	0.7
Diabetes (father)	1.2	1.5	2.2	1.5	1.1	1.5	0.9	1.3	1.0
Leg fat-free mass (left)	1.2	6.4	12.5	2.3	0.0	2.4	2.2	3.5	3.2
Leg predicted mass (left)	1.2	6.5	12.5	2.4	0.1	2.4	2.2	3.5	3.2
Glaucoma (self-reported)	1.2	1.4	4.0	-0.7	-0.8	-0.8	-2.0	-0.8	-1.3
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.1	-1.4	-1.4	-1.4	-1.0	-0.9	-0.8
Serious illness, injury or assault to yourself	1.1	1.4	3.0	1.7	1.6	0.5	1.2	0.9	0.7
Medication: Lansoprazole	1.1	1.2	2.4	1.2	1.6	0.3	0.7	1.5	0.8
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.8	1.9	1.5	0.4	0.6	0.8	0.6
Illnesses of siblings: Diabetes	1.1	1.4	3.5	-1.8	-1.9	-1.1	0.0	-0.4	0.3
Ever had bowel cancer screening	1.1	1.3	3.2	1.3	1.8	1.0	0.5	1.2	0.6
Number of operations (self-reported)	1.1	1.7	2.3	1.3	1.1	1.5	1.5	0.8	1.4
Risk taking	1.1	1.6	3.9	0.9	0.1	1.2	1.2	1.4	2.0
Alcohol drinker status: Previous	1.1	1.3	3.7	-0.6	-0.3	-0.7	-1.1	-1.9	-1.4
Bipolar Disorder (2011)	1.0	0.9	2.8	1.6	1.7	0.2	-0.0	0.4	-0.0
Waist Hip Ratio (WHR)	1.0	4.5	6.8	-1.7	-1.6	-2.3	-2.6	-2.1	-2.3
Hypothyroidism (self reported)	1.0	2.3	6.9	-0.8	-2.6	-1.3	-0.9	-1.1	-1.5
Fluid intelligence score	1.0	2.2	3.5	1.1	1.6	1.3	1.5	1.4	1.9
Birth weight of first child	1.0	1.8	4.9	-1.0	-1.5	-1.1	-2.2	-0.7	-1.1
Blood clot in the leg (DVT)	1.0	1.3	3.5	1.3	0.8	-0.3	-1.9	-0.3	-1.4
Comparative body size at age 10	1.0	2.8	5.6	1.5	0.1	1.0	2.4	2.1	1.8
Medication for pain relief, constipation, heartburn	1.0	1.7	4.2	-1.8	-2.1	-0.3	-1.0	-1.2	-0.6
Medication: Seretide 50 evohaler	1.0	1.1	1.4	1.0	1.1	0.9	1.1	1.0	1.2
Had major operations	1.0	1.2	2.2	1.5	1.3	1.0	1.3	0.2	0.8
Medication for cholesterol	1.0	1.4	3.3	0.6	0.8	1.4	1.8	0.7	1.4
Guilty feelings	1.0	1.6	4.8	-1.3	-2.2	-1.0	-0.0	-0.2	-1.3
Ever taken oral contraceptive pill	1.0	1.2	1.8	1.1	1.3	0.1	1.1	1.3	1.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.4	1.5	1.2	-0.0	-1.6	0.0	-1.1
Schizophrenia vs Biploar Disorder	0.9	1.2	1.8	-1.3	-1.3	-0.9	-0.9	-1.1	-0.8
Ovarian Cancer	0.9	1.2	2.6	-0.3	0.2	-1.1	-1.5	-0.8	-1.6
Primary Biliary Cirrhosis	0.9	1.3	2.8	0.8	0.9	0.4	1.7	1.1	1.5
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.7	-1.4	-1.6	-0.5	-0.2	-0.9	-0.5
Type 2 Diabetes (T2D) (2018)	0.9	1.8	4.4	0.8	0.2	1.6	2.1	0.9	1.5
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.5	1.0	1.2	1.6	0.6	-0.2	0.4
Medication: Co-codamol	0.9	1.0	1.7	1.3	1.1	1.0	0.6	0.8	1.0
Pain all over the body in last month	0.9	1.0	2.7	1.7	1.0	1.4	-0.4	0.3	0.0
Mouth/teeth dental problems: Dentures	0.9	1.6	2.9	1.6	1.0	1.7	1.2	0.8	1.0
Loud music exposure frequency	0.9	1.0	3.3	0.1	-0.0	1.1	0.9	0.8	1.8
Worry too long after embarrassment	0.9	1.5	3.4	-1.0	-0.9	-1.8	-1.0	-1.0	-1.3
Mood swings	0.9	1.7	3.9	-0.2	-2.0	-0.5	-1.1	-1.1	-1.9
Hearing aid user	0.9	1.0	1.7	-0.6	-1.3	-1.1	-1.0	-0.6	-1.2
Worry (Nagel 2018)	0.8	1.6	2.5	-1.0	-1.1	-0.9	-1.3	-1.5	-1.6
Triglycerides	0.8	1.3	3.5	-1.8	-1.9	-0.9	-0.3	-0.3	0.1
Average weekly fortified wine intake	0.8	0.9	1.8	0.9	0.8	0.3	1.2	0.9	1.3
Sitting height	0.8	6.0	8.5	-2.3	-2.8	-2.9	-2.9	-1.4	-1.9
Falls in the last year	0.8	1.1	2.4	-0.1	0.0	-1.6	-1.4	-0.1	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.0	-0.4	-0.0	-1.4	-1.2	-0.9	-1.1
Suffer from ‘nerves’	0.8	1.3	2.8	-0.9	-1.7	-0.6	-0.9	-1.2	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	3.5	0.4	0.4	1.9	0.7	-0.9	0.6
Medication: Aspirin	0.8	1.1	2.4	1.3	1.0	1.6	0.6	0.7	0.8
Long-standing illness, disability or infirmity	0.8	1.2	3.4	1.2	1.4	0.5	1.8	0.4	0.3
Qualifications: nursing, teaching	0.8	1.2	3.5	0.1	0.6	0.4	1.6	1.0	1.9
Average weekly champagne plus white wine intake	0.8	1.1	2.6	-1.5	-1.0	-1.6	0.0	-0.5	-0.3
Alzheimer’s Disease (in father)	0.7	0.8	1.9	-0.3	0.4	0.9	0.7	1.4	1.2
Allergy or Eczema	0.7	1.9	3.3	1.6	1.8	1.0	1.2	1.3	1.1
Relative age voice broke	0.7	1.1	3.3	-0.2	0.9	0.4	1.8	0.6	1.3
Past tobacco smoking	0.7	1.3	2.0	-1.3	-0.4	-1.2	-1.1	-1.4	-1.1
Number of live births	0.7	0.9	1.9	1.3	1.4	0.5	-0.2	1.1	0.7
Happiness	0.7	0.9	2.5	-0.6	-1.6	-0.5	-0.7	-1.0	-0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.3	1.5	0.4	0.8	0.6	1.2	0.3
Number of children fathered	0.7	0.8	2.2	-1.5	-0.8	-1.0	-0.1	-0.8	-0.2
Shortness of breath walking on level ground	0.7	0.8	1.7	1.3	0.5	1.3	0.7	0.5	0.8
Breast cancer (self-reported)	0.7	0.9	2.2	0.7	1.0	1.0	1.5	0.6	0.4
Miserableness	0.7	1.2	4.9	-0.3	-2.2	-0.4	-0.9	-0.5	-1.0
Alcohol drinker status: Never	0.7	0.8	1.6	1.3	0.6	1.2	0.8	0.5	0.9
Age started oral contraceptive pill	0.7	0.9	1.7	1.3	1.3	1.2	0.3	0.5	-0.0
Unable to work because of sickness or disability	0.7	0.9	2.5	1.6	1.0	1.1	0.8	0.3	0.5
Basal cell carcinoma (self-reported)	0.7	0.8	1.3	-0.9	-1.1	-0.7	-1.1	-0.9	-0.6
Neuroticism (2016)	0.6	0.8	1.4	-0.7	-1.0	-0.9	-1.2	-0.5	-1.0
Number of treatments/medications taken	0.6	1.0	2.9	1.7	1.4	-0.0	1.0	0.4	-0.2
Taking other prescription medications	0.6	0.9	3.0	1.7	1.1	0.5	1.0	0.3	-0.2
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.3	1.2	1.5	0.7	1.0	1.1	0.9
Multivitamins +/- minerals	0.6	0.7	1.7	1.1	1.3	-0.2	-0.8	0.9	-0.1
Stomach or abdominal pain in last month	0.6	0.7	1.6	-1.2	-1.3	-0.9	-0.5	0.1	-0.5
Supplements: Glucosamine	0.6	0.8	2.8	0.7	0.9	0.2	0.5	1.7	0.7
Medication: Atenolol	0.6	0.7	1.2	0.9	1.0	0.8	0.1	1.1	0.6
High blood pressure (mother)	0.6	0.9	2.5	-0.5	-0.2	-1.6	-0.9	-0.8	-1.0
Alcohol intake versus 10 years previously	0.6	0.9	2.0	1.1	0.4	0.9	1.4	0.6	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.3	1.5	0.9	1.0	0.7	1.0	-0.6
Medication: Paracetamol	0.6	1.0	2.8	1.7	1.6	-0.3	-0.0	0.6	-0.3
Body fat percentage	0.6	2.2	4.5	0.2	-1.7	-1.3	-2.1	-0.3	-2.0
Health satisfaction	0.6	0.8	1.3	-0.4	-0.6	-0.9	-1.0	-1.0	-1.1
Leg fat mass (right)	0.6	2.4	5.2	0.1	-2.3	-1.3	-2.1	-0.1	-1.8
Leg pain on walking	0.6	0.7	1.8	0.2	0.0	-1.0	-0.6	-1.1	-1.4
Whole body fat-free mass	0.6	3.2	7.4	1.6	-0.6	1.8	1.0	2.7	2.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.7	0.7	-0.0	1.3	0.3	0.6	0.9
High cholesterol (Self-reported)	0.6	1.0	2.9	1.0	1.7	0.2	0.6	1.1	0.8
Age at First Birth	0.5	0.7	2.7	-0.8	0.0	-1.6	-0.2	-0.4	-0.6
Mean Putamen Volume	0.5	0.6	1.2	1.0	1.1	0.1	0.7	0.9	0.2
Fasting Glucose	0.5	0.6	1.8	0.9	-0.2	0.5	0.5	0.9	1.3
Blood Red Count	0.5	4.8	8.0	2.1	2.8	1.9	1.0	2.5	2.2
Systolic Blood Pressure	0.5	2.4	8.8	-3.0	-0.6	-2.3	0.4	-0.1	-0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.6	-0.1	-1.6	-0.4	-0.1	-0.5	-1.0
Diabetes (mother)	0.5	0.7	1.7	-0.6	-0.9	-0.3	-0.9	-0.5	-1.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.6	-0.4	-0.3	-1.2	0.0	-0.7	-1.3
Number of incorrect matches in round	0.5	0.9	3.1	-1.8	-0.8	-0.6	-0.3	-0.9	-0.5
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.5	1.2	0.8	0.7	1.1	0.1	0.5
Impedance of arm (right)	0.5	2.1	4.3	-0.8	0.4	-2.1	-1.1	-1.7	-1.9
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.9	-1.1	-0.6	-1.3	-2.0	-1.1	-1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.1	-1.8	-0.7	-1.4	-0.3	-0.6	-0.6
Mean time to correctly identify matches	0.5	0.9	1.8	1.3	1.3	0.7	0.3	1.1	0.2
Alcohol intake frequency.	0.5	1.1	3.5	0.3	-0.8	0.1	-1.0	-1.9	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	1.1	1.1	-0.4	-0.1	0.7	-0.6
Commuting to job workplace: Walk	0.5	0.5	1.9	0.6	0.2	-0.1	1.4	0.8	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	1.3	0.8	0.8	0.5	0.6	0.5
Osteoarthritis (self-reported)	0.5	0.6	1.5	0.9	-0.3	0.2	-1.2	-0.5	-1.0
Whole body water mass	0.5	3.0	7.0	1.4	-0.7	1.8	1.0	2.6	2.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.2	-0.6	-0.3	-0.7	-1.1	-0.4	-1.0
Medication: Lisinopril	0.5	0.6	1.7	-1.2	-0.6	-1.3	0.4	0.0	0.6
Leg fat mass (left)	0.5	1.9	4.8	0.2	-2.2	-0.8	-1.9	-0.0	-1.6
Verbal and Numeric Reasoning (VNR)	0.4	1.0	1.6	1.0	1.0	0.9	1.3	0.8	1.1
Body Mass Index (BMI) (2010)	0.4	0.6	2.2	-0.7	-1.5	-0.9	-0.2	-0.3	-0.0
HDL Cholesterol	0.4	0.7	1.5	1.0	0.4	-0.3	-0.6	-1.1	-1.2
Chronotype (morning person)	0.4	0.9	2.1	-1.1	-0.3	-0.3	-1.4	-1.2	-0.7
Hair Pigment	0.4	10.5	16.1	-3.5	-3.8	-4.0	-2.4	-2.6	-2.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	0.9	-0.1	-0.3	-0.7	-0.7	-1.1
Maternal smoking around birth	0.4	0.5	1.6	-0.2	-1.3	-0.2	-1.2	-0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	4.3	-0.9	-2.1	-0.4	0.2	-0.2	0.1
Had other major operations	0.4	0.5	1.7	1.0	0.6	1.3	-0.1	0.1	0.3
Forced vital capacity (FVC)	0.4	1.4	4.4	-0.7	-0.4	-1.0	-2.1	-1.0	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	4.3	-1.0	-2.1	-0.0	0.5	0.1	0.4
Medication: Simvastatin	0.4	0.5	1.9	0.0	1.4	-0.7	-0.2	0.9	0.3
Asthma	0.4	0.8	1.7	1.2	0.5	0.6	0.6	1.3	0.8
Illnesses of mother	0.4	0.5	1.0	0.6	0.7	1.0	0.7	0.2	0.8
Pulse wave reflection index	0.4	0.5	1.7	0.0	0.1	1.3	0.7	0.2	0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	3.0	0.2	-1.7	-0.4	-0.2	-0.8	-1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	1.3	0.1	-0.0	-0.7	1.0	0.1
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	0.7	-0.9	0.1	-0.6	-0.5	-0.8
Exposure to tobacco smoke outside home	0.4	0.5	0.9	0.8	-0.9	-0.5	-0.9	-0.0	-0.7
Medication: Blood pressure	0.4	0.8	2.3	0.1	0.5	-0.1	1.5	1.1	0.9
Migraine (self-reported)	0.4	0.6	1.3	-1.1	0.4	-0.9	0.8	0.0	0.7
Medication: Omeprazole	0.4	0.4	0.9	1.0	0.6	0.9	0.5	-0.5	-0.3
Chest pain or discomfort	0.4	0.5	1.6	0.3	-0.5	-0.3	-0.5	-0.9	-1.3
Knee pain experienced in last month	0.4	0.6	1.4	0.6	-1.2	0.6	-0.5	-0.5	-0.9
Loneliness, isolation	0.4	0.5	2.4	0.2	-1.6	-0.2	0.7	-0.2	-0.0
Mineral and other dietary supplements	0.4	0.6	0.8	-0.9	-0.8	-0.9	0.9	0.3	0.6
Osteoporosis (self-reported)	0.4	0.4	2.4	0.3	1.5	-0.4	0.1	0.1	-0.3
Medication: Paracetamol	0.4	0.7	1.4	1.2	1.0	-1.0	-0.3	0.2	-0.8
Basal metabolic rate	0.4	2.4	6.0	1.5	-0.8	1.5	0.6	2.4	1.7
Average weekly beer plus cider intake	0.4	0.6	1.9	1.4	0.6	0.9	0.1	0.5	0.4
Fractured/broken bones in last 5 years	0.4	0.5	1.7	-0.1	0.5	-1.3	-0.8	-0.2	-0.7
Diastolic blood pressure, automated reading	0.4	1.2	3.0	-1.7	-1.4	-1.4	0.5	0.1	-0.2
Ever depressed for a whole week	0.4	0.5	0.7	-0.8	-0.6	-0.6	-0.6	-0.7	-0.8
Commuting to job workplace: Cycle	0.4	0.5	1.9	-0.5	0.2	-1.4	0.4	0.2	0.7
Pack years of smoking	0.4	0.6	1.9	1.4	0.9	0.4	-0.0	0.6	-0.5
Depression (Nagel 2018)	0.3	0.4	2.0	0.1	-1.4	-0.2	-0.3	-0.3	-0.6
Alzheimer’s Disease (in mother)	0.3	0.4	0.8	-0.5	-0.5	0.9	0.8	0.3	0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.9	-0.4	0.7	0.6	0.6	0.5
Major Depression (MDD)	0.3	0.4	1.5	-1.2	-0.6	-0.2	0.0	-0.4	-0.4
Reaction Time	0.3	0.7	1.3	1.0	1.0	0.6	0.4	1.1	0.3
Ulcerative Colitis	0.3	0.4	1.1	-1.1	-0.5	-0.7	-0.4	-0.6	-0.3
Relative age of first facial hair	0.3	0.7	1.7	0.5	0.8	-0.4	1.3	0.5	1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	-0.9	-0.6	-0.7	-0.4	-0.9	-0.3
Systolic blood pressure, automated reading	0.3	0.9	2.4	-1.6	-0.8	-1.3	0.1	-0.1	-0.7
Pack years adult smoking proportion	0.3	0.4	1.2	1.1	0.5	0.1	-0.3	0.4	-0.8
Trunk fat percentage	0.3	1.1	2.6	0.6	-1.2	-0.7	-1.6	0.2	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	2.0	0.1	-1.4	0.2	-0.2	-0.2	-0.7
Body mass index (BMI)	0.3	1.2	2.2	1.5	-1.0	1.1	0.3	1.5	0.5
Waist circumference	0.3	1.2	2.4	0.9	-1.5	-0.6	-1.6	0.5	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.5	0.2	-0.9	-0.7	0.3	-0.6	-1.2
Financial difficulties in last 2 years	0.3	0.4	1.7	1.3	0.4	0.4	0.1	0.6	-0.2
Trunk fat-free mass	0.3	1.6	4.0	1.0	-1.0	1.2	0.2	2.0	1.4
Father’s age at death	0.3	0.4	0.9	-0.2	0.9	0.6	0.6	0.1	1.0
Trunk predicted mass	0.3	1.7	4.1	1.1	-0.9	1.3	0.3	2.0	1.4
Exposure to tobacco smoke at home	0.3	0.3	1.0	-0.3	-0.4	0.2	-0.7	-1.0	-0.5
Tense / ‘highly strung’	0.3	0.5	1.4	-0.2	-0.1	-1.2	-0.0	-0.2	-1.1
Pulse wave peak to peak time	0.3	0.3	0.9	0.0	0.3	-0.6	-0.3	1.0	0.5
Qualifications: College or University degree	0.3	1.0	2.2	-1.4	-0.5	-1.5	-0.9	-0.9	-0.3
Emphysema/chronic bronchitis	0.3	0.3	0.8	0.8	-0.1	0.6	0.1	0.9	0.2
Neck or shoulder pain in last month	0.3	0.4	1.9	1.4	0.3	0.2	0.1	0.6	-0.3
Heart disease (mother)	0.3	0.3	1.3	0.5	1.1	0.3	0.3	0.4	0.3
Whole body fat mass	0.3	1.3	2.8	0.7	-1.7	-0.6	-1.6	0.5	-1.2
Arm predicted mass (right)	0.3	1.3	3.5	0.8	-1.2	1.0	-0.4	1.9	1.1
Overall health rating	0.3	0.6	1.8	1.0	0.2	-0.7	-0.7	-0.2	-1.4
Family relationship satisfaction	0.3	0.4	1.0	0.3	-1.0	0.1	0.1	0.9	0.6
Illnesses of father: Heart disease	0.3	0.4	1.3	-0.2	-0.4	-0.1	-1.1	-0.0	-1.2
Smoking status: Previous	0.3	0.5	0.9	0.6	0.2	0.6	0.8	1.0	0.7
Asthma (self-reported)	0.3	0.6	1.2	1.1	0.6	0.3	0.5	1.1	0.7
Medication: Aspirin	0.3	0.4	1.1	0.9	0.5	1.0	0.2	0.3	0.2
Financial situation satisfaction	0.3	0.4	1.2	-0.4	-1.1	-0.7	-0.4	0.7	-0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.1	0.2	0.5	-0.9	-0.9	-0.8
Crohns Disease (2017)	0.2	0.4	0.8	-0.6	-0.8	0.2	-0.9	-0.6	-0.3
Ulcerative Colitis (UC)	0.2	0.3	1.1	-1.1	-0.6	-0.4	-0.2	-0.2	0.2
Prostate Cancer	0.2	0.2	0.7	-0.8	-0.6	-0.4	-0.2	0.1	0.1
Crohns Disease (2012)	0.2	0.3	0.8	-0.8	-0.9	-0.0	-0.4	-0.4	-0.5
Rheumatoid Arthritis	0.2	0.2	0.6	-0.3	-0.1	0.0	0.6	0.8	0.5
BMI	0.2	1.2	2.9	1.0	-1.3	0.5	1.0	1.7	0.4
Hand grip strength (left)	0.2	0.5	2.0	0.3	-0.2	-0.3	0.4	1.4	0.9
Hearing difficulty/problems: Yes	0.2	0.3	1.1	0.5	-1.0	-0.5	-0.2	-0.2	-0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.3	0.3	0.5	-0.3	-0.6	-0.5
Vitamin and mineral supplements	0.2	0.3	0.9	-0.1	0.0	0.1	0.8	0.6	1.0
Townsend deprivation index at recruitment	0.2	0.3	1.1	1.0	-0.5	0.4	-0.4	0.1	-0.5
Current tobacco smoking	0.2	0.3	0.9	1.0	-0.2	0.7	-0.0	-0.5	-0.2
Age when periods started (menarche)	0.2	0.6	2.1	-1.4	-0.8	0.2	-0.3	-0.7	-0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.8	-0.3	0.1	-0.3	-0.3	0.4
Qualifications: CSEs or equivalent	0.2	0.2	0.5	0.1	-0.7	0.1	0.6	-0.6	-0.6
Medication: Levothyroxine sodium	0.2	0.3	0.9	0.3	-0.9	0.0	0.9	0.2	0.2
Trunk fat mass	0.2	1.0	2.2	0.8	-1.5	-0.4	-1.3	0.7	-0.9
Had menopause	0.2	0.3	0.7	0.8	0.6	0.7	-0.3	-0.1	-0.1
Heart attack	0.2	0.3	0.9	0.9	0.2	-0.0	0.6	0.2	-0.4
Medication: Ramipril	0.2	0.3	0.6	0.3	0.7	-0.8	0.5	0.2	-0.2
Weight	0.2	1.2	3.0	1.5	-1.2	0.6	-0.3	1.7	0.4
Hip circumference	0.2	0.8	1.7	1.3	-1.0	0.3	-0.6	1.2	-0.5
Pulse rate	0.2	0.4	1.3	-0.4	-0.7	0.2	1.1	-0.5	0.2
Noisy workplace	0.2	0.2	1.0	0.2	-1.0	0.1	-0.3	0.3	-0.1
Medication: Cholesterol lowering	0.2	0.3	0.9	0.4	0.9	-0.2	0.6	0.6	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.5	-0.3	0.5	-1.0	-1.2	-0.1	-0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.1	-0.2	0.6	0.4	-0.7	-0.4
Impedance of arm (left)	0.2	0.9	2.2	0.4	1.5	-1.2	-0.2	-1.0	-0.9
Arm fat mass (right)	0.2	0.8	1.6	1.2	-1.2	0.6	0.1	1.3	0.1
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	0.8	0.1	0.4	-0.3	-0.8	-0.8
Peak expiratory flow (PEF)	0.2	0.5	0.9	-0.9	-0.7	-0.7	-0.8	-0.8	-0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.5	0.0	0.7	-0.4	-0.5	-0.7	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.5	-0.2	-0.5	-0.5	-0.7	-0.6	-0.3
Headache pain in last month	0.2	0.4	1.2	-0.4	-0.5	-0.5	1.1	0.5	0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.5	0.1	-0.8	0.1	-1.2	-0.4	-0.4
Forced vital capacity (FVC), Best measure	0.2	0.6	2.1	-0.4	0.4	-1.0	-1.4	-0.3	-0.7
Arm fat-free mass (right)	0.2	1.2	3.6	0.8	-1.1	0.8	-0.3	1.9	1.1
Number of full brothers	0.2	0.3	0.7	0.5	-0.4	-0.6	-0.8	0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.8	-0.2	0.1	0.9	0.5	0.3	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.2	0.2	0.6	0.7	-0.1	0.7
Comparative height size at age 10	0.2	0.9	3.0	0.5	-0.5	-0.3	-1.7	1.3	-0.2
Age at last live birth	0.2	0.3	0.7	-0.9	-0.5	-0.7	-0.5	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.0	-0.2	-0.8	-0.8	-1.0	0.3	-0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.8	0.5	-0.1	-0.9	-0.6	0.2	0.1
Arm fat mass (left)	0.2	0.8	1.6	1.2	-1.3	0.4	-0.0	1.2	0.0
Number of self-reported non-cancer illnesses	0.2	0.4	0.8	0.8	0.9	-0.1	-0.0	-0.4	-0.9
Wears glasses or contact lenses	0.2	0.2	0.8	0.2	0.9	0.3	-0.2	0.3	-0.0
Mother’s age at death	0.2	0.3	0.8	0.2	0.0	0.8	0.0	-0.9	-0.2
Illnesses of father: High blood pressure	0.2	0.3	0.6	-0.7	-0.7	0.4	0.5	-0.4	0.2
Ever smoked	0.2	0.3	0.9	0.8	-0.1	0.9	0.0	0.5	0.3
Arm fat-free mass (left)	0.2	1.0	3.6	0.1	-1.9	0.3	-1.0	1.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.7	0.5	0.5	0.6	0.1	-0.1
Pain experienced in last month	0.2	0.3	1.1	-1.1	-0.0	0.1	-0.4	-0.5	0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	0.8	0.2	-0.4	0.6	0.2	-0.6
Arm predicted mass (left)	0.2	1.0	3.0	0.5	-1.7	0.5	-0.9	1.4	0.4
Bipolar Disorder (2018)	0.1	0.2	0.8	0.4	0.5	-0.2	0.3	0.9	0.1
Bipolar Disorder or Schizophrenia	0.1	0.1	0.4	0.4	0.3	0.3	-0.1	0.6	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.3	0.6	0.0	1.1	-0.1	-0.1	0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	-0.8	-0.8	-0.0	-0.7	-0.6	-0.1
Lupus	0.1	0.2	0.7	0.2	-0.3	0.5	-0.8	0.4	-0.0
Blood Eosinophil Count	0.1	0.6	1.5	0.9	0.1	-0.7	0.8	1.2	0.5
Blood White Count	0.1	0.5	1.1	0.2	-0.1	-0.8	-1.0	-0.6	-0.9
Smoking Status	0.1	0.2	0.9	0.9	0.0	0.2	-0.1	0.0	-0.0
Cardiovascular Disease	0.1	0.2	0.8	0.1	0.9	-0.2	0.6	0.5	0.1
Respiratory disease	0.1	0.2	0.3	0.5	0.3	-0.4	-0.4	0.4	-0.5
Lung FVC	0.1	0.7	2.2	-0.0	1.5	-0.2	-0.9	-1.0	-0.3
Angina	0.1	0.1	0.4	0.3	0.4	-0.6	-0.1	-0.2	0.0
Hand grip strength (right)	0.1	0.4	0.9	-0.5	-0.8	-0.5	-0.1	0.9	0.5
High blood pressure	0.1	0.4	0.9	-0.6	0.0	-0.9	0.4	0.8	0.2
Alcohol usually taken with meals	0.1	0.1	0.4	-0.2	0.6	-0.3	-0.4	-0.1	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.4	-0.5	-0.1	0.0	-0.2	0.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.4	-0.6	-0.1	-0.1	-0.4	-0.4
Qualifications: None of the above	0.1	0.2	0.5	0.3	-0.5	-0.1	-0.5	0.5	-0.7
Mouth/teeth dental problems	0.1	0.2	0.6	-0.3	0.4	0.2	0.8	0.4	0.3
Illnesses of siblings	0.1	0.1	0.2	-0.4	0.1	0.4	0.1	0.1	-0.3
Arm fat percentage (right)	0.1	0.5	1.6	0.9	-1.3	0.1	0.0	0.7	-0.4
Time employed in main current job	0.1	0.1	0.4	0.2	0.6	0.0	-0.0	0.2	-0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.5	-0.1	0.3	-0.7	-0.1	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.0	0.4	-0.4	-0.4	-0.4	-0.4
Prospective memory result	0.1	0.1	0.3	-0.4	-0.3	-0.1	0.6	-0.3	0.2
Standing height	0.1	0.6	2.0	0.3	-0.4	-0.8	-1.4	0.9	0.0
Breastfed as a baby	0.1	0.1	0.6	0.0	0.8	0.0	-0.3	0.3	-0.0
Medication: Amlodipine	0.1	0.2	1.0	0.1	0.3	0.2	0.4	1.0	0.1
High blood pressure (siblings)	0.1	0.1	0.4	0.3	0.3	-0.6	0.1	0.1	0.4
Angina (self-reported)	0.1	0.1	0.4	0.2	0.3	-0.6	0.0	-0.2	0.0
Medication: Ibuprofen	0.1	0.1	0.4	-0.1	-0.2	-0.1	-0.4	-0.7	-0.5
Pulse rate, automated reading	0.1	0.5	2.3	0.3	0.0	-0.2	1.5	0.7	0.1
Number of full sisters	0.1	0.1	0.6	0.0	-0.4	-0.2	-0.8	-0.2	0.0
Hypertension (Self-reported)	0.1	0.3	1.0	-0.8	-0.3	-1.0	0.3	0.4	-0.0
Arm fat percentage (left)	0.1	0.6	1.8	1.3	-0.9	0.3	0.2	0.9	-0.1
Average weekly red wine intake	0.1	0.2	0.6	0.1	0.0	-0.5	-0.8	-0.2	-0.6
Medication: Gliclazide	0.1	0.1	0.3	0.6	-0.3	0.3	0.1	0.5	-0.2
Smoking status: Current	0.1	0.2	0.8	0.9	-0.1	0.5	0.0	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	-0.3	0.5	-0.2	-0.5	0.2	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	0.3	-0.0	-0.1	0.3	-0.3	-0.6
Medication: Blood pressure	0.1	0.3	0.6	-0.4	-0.1	-0.7	-0.8	0.5	0.1
Medication: Atorvastatin	0.1	0.1	0.2	0.1	0.0	-0.2	0.5	-0.3	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.0	0.4	-0.3	0.9	-0.1	-1.0	-0.3
Cholesterol lowering medication	0.1	0.2	0.6	0.5	0.7	0.5	0.0	0.1	-0.2
Heart disease (siblings)	0.1	0.1	0.3	0.5	0.5	-0.1	-0.0	-0.4	0.0
Schizophrenia (2018)	0.0	0.1	0.3	0.2	-0.0	0.5	-0.3	0.1	0.1
Schizophrenia (2014)	0.0	0.1	0.2	-0.1	-0.4	0.2	-0.4	-0.1	-0.4
Blood Platelet Count	0.0	0.2	0.4	-0.1	0.6	-0.6	-0.6	0.2	-0.1
Height	0.0	0.8	1.5	0.9	-0.6	-1.0	-1.2	0.9	-0.4
Lung FEV1/FVC ratio	0.0	0.1	0.2	-0.1	-0.2	-0.3	0.4	0.5	0.1
Tanning	0.0	0.4	1.4	-0.8	-0.0	-1.2	-0.0	0.7	0.5

Hub : Genes

BBOX1

Models

Trait associations