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chr19:16,462,417-20,451,172

Best TWAS P=8.01e-14 · Best GWAS P=5.65e-14 conditioned to 0.000654

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
91	The Cancer Genome Atlas	Thyroid Carcinoma	HAPLN4	0.08	0.06	blup	37	0.09	1.8e-09	6.8	7.5	8.0e-14	0.85	0.01	0.99	TRUE
21	GTEx	Esophagus Muscularis	MYO9B	0.13	0.02	lasso	5	0.05	9.5e-04	5.0	-7.4	1.8e-13	-0.02	0.03	0.96	TRUE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA1683	0.16	0.11	lasso	6	0.11	2.9e-12	-6.4	7.1	1.6e-12	-0.03	0.00	1.00	TRUE
50	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ISYNA1	0.05	0.03	enet	8	0.03	2.3e-03	4.4	-5.1	2.7e-07	0.10	0.00	0.42	TRUE
1	CommonMind	Brain Pre-frontal Cortex	GATAD2A	0.13	0.30	lasso	7	0.29	2.4e-35	7.3	-7.5	9.1e-14	-0.97	0.06	0.94	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA0892	0.03	0.01	lasso	7	0.02	6.3e-03	7.4	-7.4	1.0e-13	-0.94	0.01	0.83	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GATAD2A	0.02	0.02	lasso	1	0.02	2.1e-03	7.3	7.2	4.0e-13	0.96	0.03	0.70	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA0892	0.04	0.04	blup	43	0.02	4.1e-03	7.4	-7.2	4.5e-13	-0.95	0.02	0.97	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAPLN4	0.05	0.07	lasso	2	0.06	1.1e-07	7.4	7.2	5.5e-13	0.94	0.00	1.00	FALSE
39	GTEx	Whole Blood	TMEM161A	0.06	0.00	enet	2	0.00	1.4e-01	7.2	-7.2	7.5e-13	-0.97	0.04	0.81	FALSE
58	The Cancer Genome Atlas	Colon Adenocarcinoma	GATAD2A	0.04	0.03	blup	61	0.05	1.3e-03	7.0	7.1	1.1e-12	0.93	0.03	0.82	FALSE
9	GTEx	Artery Tibial	MAU2	0.07	0.05	lasso	4	0.05	1.3e-04	7.4	7.1	1.6e-12	0.88	0.03	0.94	FALSE
17	GTEx	Cells Transformed fibroblasts	GATAD2A	0.07	0.00	lasso	4	0.00	8.1e-01	7.2	7.0	2.3e-12	0.83	0.04	0.58	FALSE
47	YFS	Blood	GATAD2A	0.09	0.14	blup	365	0.14	7.5e-44	7.2	7.0	2.7e-12	0.91	0.09	0.91	FALSE
59	The Cancer Genome Atlas	Colon Adenocarcinoma	HAPLN4	0.10	0.08	blup	38	0.11	8.5e-07	7.4	7.0	3.3e-12	0.87	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAPLN4	0.07	0.05	lasso	7	0.07	2.9e-08	5.5	6.9	5.7e-12	0.83	0.03	0.97	FALSE
11	GTEx	Artery Tibial	HAUS8	0.16	0.02	lasso	7	0.02	4.7e-03	6.3	-6.9	6.9e-12	-0.01	0.10	0.86	FALSE
80	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA1683	0.09	0.05	lasso	4	0.06	1.3e-07	5.4	6.9	7.1e-12	-0.03	0.00	1.00	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSSK6	0.02	0.02	blup	33	0.02	1.8e-03	7.2	6.8	7.9e-12	0.92	0.01	0.83	FALSE
12	GTEx	Artery Tibial	CTD-3032J10.3	0.14	0.01	lasso	5	0.01	6.4e-02	7.0	-6.8	9.3e-12	0.04	0.00	0.95	FALSE
22	GTEx	Esophagus Muscularis	KIAA1683	0.10	0.04	lasso	3	0.06	1.1e-04	-6.4	6.8	1.1e-11	-0.02	0.00	0.99	FALSE
49	YFS	Blood	KIAA1683	0.51	0.40	enet	65	0.46	9.9e-171	5.4	6.7	1.6e-11	-0.02	0.37	0.63	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	HAUS8	0.13	0.10	blup	55	0.11	7.8e-12	6.3	-6.7	1.6e-11	0.02	0.11	0.89	FALSE
14	GTEx	Brain Cerebellum	SUGP2	0.15	-0.01	enet	27	0.00	2.3e-01	5.3	6.7	1.8e-11	0.68	0.04	0.50	FALSE
15	GTEx	Cells Transformed fibroblasts	KIAA1683	0.14	0.16	lasso	2	0.15	1.2e-11	-6.4	6.7	2.2e-11	-0.03	0.00	1.00	FALSE
28	GTEx	Muscle Skeletal	HAUS8	0.15	0.10	lasso	4	0.08	1.6e-08	6.4	-6.7	2.2e-11	-0.01	0.10	0.90	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	HAUS8	0.04	0.06	lasso	2	0.05	2.2e-05	6.4	-6.7	2.3e-11	0.00	0.05	0.93	FALSE
4	GTEx	Adipose Subcutaneous	KIAA1683	0.14	0.09	enet	6	0.16	2.5e-13	-6.4	6.7	2.7e-11	-0.03	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KIAA1683	0.05	0.04	enet	6	0.05	4.9e-05	-6.4	6.7	2.9e-11	-0.03	0.00	0.99	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	GATAD2A	0.04	0.03	lasso	2	0.03	2.9e-04	7.2	6.6	4.0e-11	0.91	0.05	0.88	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAUS8	0.05	0.06	enet	12	0.06	2.9e-12	6.4	-6.6	4.4e-11	0.00	0.10	0.90	FALSE
82	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HAUS8	0.20	0.13	lasso	2	0.11	2.4e-05	6.4	-6.6	5.2e-11	-0.02	0.10	0.81	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	HAPLN4	0.05	0.03	enet	15	0.03	1.7e-04	5.3	6.5	6.4e-11	0.74	0.35	0.64	FALSE
89	The Cancer Genome Atlas	Stomach Adenocarcinoma	HAUS8	0.06	0.04	blup	55	0.04	1.0e-03	6.4	-6.5	8.4e-11	0.00	0.04	0.50	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA1683	0.15	0.09	lasso	6	0.16	5.4e-15	5.5	6.5	9.5e-11	-0.03	0.02	0.98	FALSE
40	GTEx	Whole Blood	GATAD2A	0.06	0.02	lasso	9	0.03	1.7e-03	7.5	6.5	1.1e-10	0.87	0.03	0.96	FALSE
64	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAUS8	0.08	0.07	blup	55	0.07	6.7e-08	6.3	-6.5	1.1e-10	-0.04	0.11	0.89	FALSE
60	The Cancer Genome Atlas	Colon Adenocarcinoma	HAUS8	0.12	0.06	lasso	5	0.06	1.8e-04	6.3	-6.4	1.3e-10	0.02	0.12	0.80	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAPLN4	0.04	0.07	lasso	4	0.06	1.3e-12	5.6	6.4	1.5e-10	0.77	0.97	0.03	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	KIAA1683	0.23	0.14	bslmm	409	0.24	1.4e-30	-6.4	6.4	1.6e-10	-0.02	0.00	1.00	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	HAUS8	0.05	0.05	enet	7	0.05	7.1e-07	6.4	-6.4	1.7e-10	-0.01	0.10	0.90	FALSE
26	GTEx	Muscle Skeletal	SUGP1	0.11	0.06	lasso	7	0.07	9.5e-08	5.6	-6.4	1.8e-10	-0.81	0.36	0.63	FALSE
8	GTEx	Artery Aorta	HAUS8	0.18	0.12	lasso	2	0.09	7.3e-06	6.3	-6.4	1.9e-10	0.00	0.09	0.90	FALSE
31	GTEx	Prostate	KIAA1683	0.20	0.27	lasso	1	0.23	1.8e-06	-6.4	6.3	2.1e-10	-0.03	0.00	0.99	FALSE
5	GTEx	Adipose Subcutaneous	HAUS8	0.11	0.09	lasso	3	0.08	5.4e-07	6.4	-6.3	2.6e-10	-0.01	0.09	0.91	FALSE
29	GTEx	Nerve Tibial	KIAA1683	0.25	0.22	lasso	9	0.28	5.2e-20	5.4	6.3	2.6e-10	-0.02	0.18	0.82	FALSE
35	GTEx	Spleen	KIAA1683	0.26	0.17	lasso	6	0.13	3.9e-04	-6.4	6.3	2.8e-10	-0.04	0.00	0.98	FALSE
90	The Cancer Genome Atlas	Testicular Germ Cell Tumors	KIAA1683	0.17	0.06	blup	65	0.06	3.0e-03	-4.6	6.3	2.8e-10	-0.01	0.01	0.89	FALSE
27	GTEx	Muscle Skeletal	MAU2	0.09	0.04	lasso	4	0.05	5.1e-06	3.8	-6.2	4.6e-10	-0.84	0.04	0.96	FALSE
13	GTEx	Brain Cerebellar Hemisphere	HAUS8	0.44	0.15	lasso	7	0.11	8.1e-04	6.4	-6.2	4.8e-10	-0.03	0.11	0.62	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA1683	0.05	0.03	lasso	4	0.04	9.1e-06	-4.9	6.2	6.0e-10	-0.02	0.03	0.97	FALSE
77	The Cancer Genome Atlas	Lung Adenocarcinoma	HAUS8	0.04	0.04	lasso	2	0.03	1.6e-04	6.3	-6.1	8.0e-10	-0.01	0.10	0.83	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAUS8	0.09	0.14	lasso	4	0.12	5.9e-14	6.4	-6.1	9.4e-10	0.00	0.10	0.90	FALSE
87	The Cancer Genome Atlas	Soft Tissue Sarcoma	HAPLN4	0.11	0.01	blup	38	0.02	2.7e-02	5.5	6.1	1.0e-09	0.78	0.02	0.65	FALSE
34	GTEx	Spleen	ATP13A1	0.16	0.01	lasso	5	0.02	9.7e-02	7.1	6.1	1.1e-09	0.86	0.05	0.37	FALSE
23	GTEx	Esophagus Muscularis	HAUS8	0.20	0.11	lasso	4	0.09	5.1e-06	6.4	-6.1	1.2e-09	-0.04	0.10	0.87	FALSE
79	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HAUS8	0.06	0.04	enet	4	0.05	3.9e-06	5.0	-6.1	1.2e-09	-0.03	0.17	0.81	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HAPLN4	0.07	0.10	lasso	6	0.10	5.3e-12	5.6	6.1	1.3e-09	0.73	0.93	0.07	FALSE
52	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	YJEFN3	0.04	0.05	lasso	7	0.04	1.6e-04	5.2	-6.0	1.7e-09	-0.75	0.09	0.73	FALSE
78	The Cancer Genome Atlas	Lung Adenocarcinoma	KIAA1683	0.04	0.04	lasso	4	0.05	2.5e-06	-4.9	6.0	2.3e-09	-0.03	0.01	0.99	FALSE
33	GTEx	Skin Sun Exposed Lower leg	KIAA1683	0.09	0.04	enet	9	0.06	1.0e-05	-6.4	6.0	2.7e-09	-0.01	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SF4	0.03	0.01	enet	7	0.02	1.1e-03	7.2	5.9	3.1e-09	0.83	0.02	0.93	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	JUND	0.17	0.17	lasso	5	0.20	2.7e-25	5.4	5.9	3.4e-09	-0.02	0.41	0.59	FALSE
42	NTR	Blood	GATAD2A	0.02	0.02	blup	386	0.02	1.4e-07	7.4	5.9	3.6e-09	0.90	0.04	0.96	FALSE
10	GTEx	Artery Tibial	KIAA1683	0.16	0.08	enet	11	0.15	8.2e-12	-6.4	5.9	3.8e-09	-0.02	0.01	0.99	FALSE
88	The Cancer Genome Atlas	Soft Tissue Sarcoma	KIAA1683	0.07	0.00	blup	64	0.01	4.5e-02	-3.5	5.9	4.0e-09	-0.01	0.03	0.27	FALSE
3	CommonMind	Brain Pre-frontal Cortex	KIAA1683	0.09	0.06	enet	14	0.10	6.6e-12	-4.9	5.9	4.3e-09	-0.05	0.02	0.98	FALSE
18	GTEx	Colon Sigmoid	KIAA1683	0.15	0.09	lasso	6	0.09	5.1e-04	-3.7	5.8	5.0e-09	-0.03	0.01	0.97	FALSE
20	GTEx	Esophagus Mucosa	AC068499.10	0.16	0.07	lasso	5	0.08	6.7e-06	-4.9	-5.8	5.8e-09	0.05	0.65	0.09	FALSE
61	The Cancer Genome Atlas	Glioblastoma Multiforme	JUND	0.17	0.00	blup	57	0.03	5.4e-02	5.4	5.8	5.9e-09	-0.01	0.02	0.14	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KIAA1683	0.09	0.07	lasso	8	0.12	2.1e-13	-6.4	5.8	6.1e-09	-0.04	0.01	0.99	FALSE
57	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	HAUS8	0.10	0.07	blup	55	0.07	3.2e-04	6.4	-5.8	6.6e-09	-0.02	0.03	0.93	FALSE
41	METSIM	Adipose	KIAA1683	0.21	0.24	enet	21	0.27	2.1e-40	-4.6	5.8	7.6e-09	-0.02	0.02	0.98	FALSE
72	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	KIAA1683	0.13	0.02	blup	65	0.05	1.0e-03	5.5	5.8	8.6e-09	-0.02	0.02	0.94	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA1683	0.04	0.02	blup	65	0.03	2.6e-07	-6.4	5.6	1.8e-08	-0.03	0.00	1.00	FALSE
24	GTEx	Heart Atrial Appendage	KIAA1683	0.15	0.03	lasso	5	0.10	2.4e-05	5.4	5.6	2.6e-08	0.02	0.01	0.95	FALSE
48	YFS	Blood	HAUS8	0.03	0.02	lasso	6	0.02	3.3e-07	5.7	-5.5	2.9e-08	-0.02	0.17	0.83	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GMIP	0.03	0.02	lasso	4	0.02	3.2e-03	3.9	5.5	3.1e-08	0.69	0.00	0.95	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	5.4	5.5	4.6e-08	-0.01	0.10	0.47	FALSE
30	GTEx	Pituitary	KIAA1683	0.43	0.25	lasso	3	0.17	3.9e-05	5.4	5.5	4.8e-08	-0.02	0.10	0.49	FALSE
38	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	5.4	-5.4	6.5e-08	0.01	0.04	0.27	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	5.4	5.4	7.4e-08	-0.01	0.09	0.44	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	KIAA1683	0.16	0.05	enet	12	0.06	3.5e-04	-6.4	5.4	7.8e-08	-0.02	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	CILP2	0.02	0.02	blup	30	0.02	1.6e-04	5.3	5.4	8.3e-08	0.67	0.16	0.21	FALSE
81	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	KIAA1683	0.09	0.06	blup	64	0.07	2.2e-05	-6.4	5.3	8.9e-08	-0.03	0.00	1.00	FALSE
6	GTEx	Adipose Visceral Omentum	HAUS8	0.15	0.12	lasso	2	0.12	7.0e-07	6.3	-5.3	9.5e-08	0.00	0.10	0.89	FALSE
25	GTEx	Lung	NR2F6	0.17	0.00	enet	31	0.00	2.5e-01	-1.4	5.3	1.1e-07	0.03	0.06	0.04	FALSE
37	GTEx	Thyroid	YJEFN3	0.05	0.02	lasso	3	0.02	1.2e-02	5.4	-5.3	1.2e-07	-0.67	0.18	0.27	FALSE
19	GTEx	Colon Transverse	YJEFN3	0.09	0.09	lasso	3	0.07	4.3e-04	4.9	-5.3	1.3e-07	-0.60	0.28	0.32	FALSE
36	GTEx	Stomach	PLVAP	0.27	0.01	lasso	5	0.00	5.0e-01	6.4	5.3	1.4e-07	-0.02	0.04	0.37	FALSE
86	The Cancer Genome Atlas	Prostate Adenocarcinoma	YJEFN3	0.04	0.05	lasso	2	0.05	4.3e-06	5.3	-5.3	1.4e-07	-0.66	0.68	0.14	FALSE
83	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	HAUS8	0.21	0.11	enet	9	0.10	6.2e-05	-5.4	-5.2	2.0e-07	0.06	0.08	0.58	FALSE
16	GTEx	Cells Transformed fibroblasts	HAUS8	0.12	0.05	enet	19	0.05	1.0e-04	6.3	-5.2	2.1e-07	0.00	0.13	0.83	FALSE
7	GTEx	Adrenal Gland	KIAA1683	0.26	0.05	enet	21	0.19	1.7e-07	-4.8	5.1	2.9e-07	-0.02	0.01	0.98	FALSE