TWAS hub - RAVER1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.059	0.025	0.0069	0.030	0.036	0.036	0.037	0.026	0.00013	2.8e-05	2.7e-05	2.5e-05	0.00032
2	GTEx	Skin Sun Exposed Lower leg	0.108	0.041	0.0064	0.029	NA	0.025	NA	0.034	0.00180	NA	3.3e-03	NA	0.00071

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Osteoarthritis (self-reported)	11.5	14.9	24.7	-5.0	-2.2
Age when periods started (menarche)	11.3	27.2	49.0	7.0	2.3
Ever had hysterectomy (womb removed)	5.4	6.1	11.2	3.3	1.0
Impedance of leg (right)	4.7	22.9	45.7	6.8	-0.2
Supplements: Glucosamine	4.5	5.9	6.4	-2.5	2.3
Ever taken oral contraceptive pill	4.5	5.0	10.0	3.2	0.1
Impedance of leg (left)	4.2	20.3	40.6	6.4	0.0
Impedance of whole body	4.2	21.5	42.8	6.5	0.4
Pack years adult smoking proportion	4.1	6.2	7.5	2.7	2.2
Pack years of smoking	4.0	5.9	5.9	2.4	2.4
Lung FVC	3.6	18.2	33.8	-5.8	1.6
Impedance of arm (right)	3.6	16.6	31.2	5.6	1.4
Trunk fat-free mass	3.3	18.8	33.4	-5.8	-2.1
Birth weight of first child	3.3	6.0	10.0	-3.2	1.4
Mouth/teeth dental problems: Mouth ulcers	3.3	5.2	9.0	-3.0	1.2
Reaction Time	3.2	6.2	8.6	2.9	1.9
Trunk predicted mass	3.2	18.3	32.7	-5.7	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.9	3.9	2.0	2.0
Average weekly fortified wine intake	3.1	3.6	4.8	1.6	-2.2
Forced vital capacity (FVC), Best measure	3.1	11.3	21.9	-4.7	-0.9
Number of full sisters	3.1	3.7	7.3	2.7	-0.4
Whole body water mass	3.1	17.5	31.5	-5.6	-1.8
Arm predicted mass (right)	3.0	15.4	24.8	-5.0	-2.4
Forced vital capacity (FVC)	2.9	11.2	21.8	-4.7	-0.7
Impedance of arm (left)	2.9	13.6	26.8	5.2	0.7
Arm fat-free mass (right)	2.9	14.9	24.8	-5.0	-2.2
Whole body fat-free mass	2.9	16.8	30.4	-5.5	-1.8
Guilty feelings	2.9	4.4	8.4	2.9	0.6
Tinnitus: Yes, now most or all of the time	2.9	3.4	5.3	-2.3	1.2
Maternal smoking around birth	2.6	3.8	7.6	2.8	0.1
Stomach or abdominal pain in last month	2.6	3.3	3.9	-1.6	-2.0
Qualifications: nursing, teaching	2.6	4.0	8.0	-2.8	0.1
Leg fat-free mass (right)	2.5	13.4	25.2	-5.0	-1.2
Medication for cholesterol	2.5	3.9	4.3	1.9	-2.1
Leg predicted mass (right)	2.5	13.4	25.3	-5.0	-1.2
Arm predicted mass (left)	2.5	12.6	21.7	-4.7	-1.9
Arm fat-free mass (left)	2.4	12.1	20.6	-4.5	-1.9
Medication for hormone replacement therapy	2.3	2.5	2.8	-1.5	1.7
Medication: Cholesterol lowering	2.3	3.6	6.5	2.6	0.8
Qualifications: O levels/GCSEs or equivalent	2.3	3.7	6.5	-2.5	-0.9
Worry too long after embarrassment	2.3	3.9	7.7	2.8	0.4
Comparative height size at age 10	2.3	12.7	21.2	-4.6	-2.1
Waist Hip Ratio (WHR)	2.2	10.1	20.1	4.5	-0.3
Severe depression (siblings)	2.2	2.4	4.1	2.0	0.9
Forced expiratory volume in 1-second (FEV1)	2.2	7.5	14.7	-3.8	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.0	13.3	-3.7	-0.8
Chest pain or discomfort	2.2	3.1	6.2	2.5	0.3
Ever had bowel cancer screening	2.2	2.5	5.1	-2.2	-0.1
Illnesses of father: None of the above (group 1)	2.2	2.8	5.0	-2.2	-0.7
Basal metabolic rate	2.2	12.1	21.4	-4.6	-1.6
Bipolar Disorder (2018)	2.1	3.3	6.4	2.5	0.4
Medication: Amlodipine	2.1	2.9	5.7	-2.4	-0.3
Neck or shoulder pain in last month	2.1	3.0	3.5	-1.6	-1.9
Mean time to correctly identify matches	2.1	3.9	5.2	2.3	1.6
Had major operations	2.1	2.5	4.7	-2.2	0.5
Breast cancer (self-reported)	2.1	2.5	3.7	1.1	1.9
Crohns Disease (2012)	2.0	3.2	6.4	2.5	0.0
Rheumatoid Arthritis	2.0	2.7	5.2	-2.3	-0.4
Leg fat-free mass (left)	2.0	10.7	19.8	-4.5	-1.3
Relative age voice broke	2.0	3.0	5.3	2.3	0.9
Leg predicted mass (left)	2.0	10.7	19.5	-4.4	-1.4
Intelligence (Savage-Jansen 2018)	1.9	5.8	7.2	-2.1	2.7
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	3.6	-1.9	-1.2
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.5	-2.1	0.5
Pain experienced in last month	1.9	3.2	6.0	2.4	0.7
Alzheimer’s Disease (in mother)	1.8	2.2	4.2	0.3	-2.1
Height	1.8	34.7	35.2	-5.9	-5.8
Diabetes (father)	1.8	2.2	2.3	1.5	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	7.6	-2.8	0.3
Ever depressed for a whole week	1.8	2.2	3.8	1.9	-0.8
Mouth/teeth dental problems	1.7	2.6	4.0	2.0	-1.1
Breastfed as a baby	1.7	2.1	3.9	-2.0	0.6
Medication: Bendroflumethiazide	1.7	2.6	5.0	0.4	2.2
Schizophrenia (2018)	1.6	3.3	6.5	-0.5	2.5
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.4	1.8	0.6
Medication: Lansoprazole	1.6	1.9	2.7	-1.0	-1.6
Heart disease (mother)	1.6	1.9	2.0	1.4	-1.4
Medication: Blood pressure	1.6	3.0	3.7	-1.5	1.9
Ever had prostate specific antigen (PSA) test	1.6	1.9	3.7	1.9	0.2
Fractured/broken bones in last 5 years	1.6	2.1	2.3	-1.5	-1.3
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.1	-1.8	0.7
High blood pressure (mother)	1.5	2.0	3.4	-1.8	0.8
Had other major operations	1.5	1.8	3.4	-1.8	-0.4
Allergy	1.5	3.4	5.6	-1.1	2.4
Medication: Ramipril	1.5	1.9	3.8	1.9	-0.2
Illnesses of father: Heart disease	1.5	2.0	3.9	2.0	0.3
Medication: Paracetamol	1.5	2.3	3.9	-2.0	0.9
Illnesses of father: High blood pressure	1.5	1.9	2.9	0.9	1.7
Coronary Artery Disease (CAD)	1.4	1.7	3.3	1.8	0.3
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	2.2	1.5	1.0
Alcohol usually taken with meals	1.4	2.2	4.5	-2.1	-0.1
Qualifications: None of the above	1.4	2.9	4.8	2.2	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	3.2	-1.8	0.1
Hypothyroidism/myxoedema (self-reported)	1.4	2.6	5.2	-0.3	-2.3
Medication: Aspirin	1.4	1.9	3.8	-0.0	-1.9
Wears glasses or contact lenses	1.4	1.6	2.3	-1.0	-1.5
Alzheimer’s Disease (including proxy)	1.3	1.9	3.5	0.5	-1.9
Hypothyroidism (self reported)	1.3	3.0	5.9	-0.3	-2.4
Trunk fat percentage	1.3	5.3	9.7	3.1	0.9
Serious illness, injury or assault to yourself	1.3	1.5	1.7	-1.3	-1.2
Financial difficulties in last 2 years	1.3	1.7	1.7	-1.3	-1.3
Medication: Paracetamol	1.3	2.2	3.5	-1.9	1.0
Leg fat percentage (right)	1.3	4.9	9.7	3.1	0.3
Mineral and other dietary supplements	1.3	1.7	2.3	1.5	-1.1
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.3	-1.8	0.2
Medication: Atorvastatin	1.3	1.5	3.1	1.8	0.0
Ovarian Cancer	1.2	1.5	2.2	1.5	1.0
Mean Putamen Volume	1.2	1.4	1.9	-0.9	1.4
LDL Cholesterol	1.2	1.9	2.8	1.7	1.1
Hayfever, allergic rhinitis or eczema	1.2	2.6	4.8	0.6	-2.2
Sitting height	1.2	8.4	12.9	-3.6	-2.0
Chronic bronchitis/emphysema (father)	1.2	1.4	2.8	-0.0	-1.7
Number of incorrect matches in round	1.2	1.9	2.1	1.3	1.4
Body fat percentage	1.2	4.9	9.0	3.0	0.9
Number of children fathered	1.2	1.3	2.4	1.5	-0.5
Basal cell carcinoma (self-reported)	1.2	1.5	2.9	0.3	-1.7
Bipolar Disorder or Schizophrenia	1.1	2.7	4.0	1.2	2.0
Hand grip strength (left)	1.1	2.9	5.6	2.4	0.5
Relative age of first facial hair	1.1	2.2	4.4	2.1	0.1
Time employed in main current job	1.1	1.2	1.7	-1.3	0.9
Alcohol intake versus 10 years previously	1.1	1.7	3.3	1.8	-0.1
Peak expiratory flow (PEF)	1.1	2.5	4.5	-2.1	-0.8
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	2.3	0.6	1.5
Family relationship satisfaction	1.1	1.3	1.9	0.8	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	4.6	-2.1	0.0
Average weekly champagne plus white wine intake	1.1	1.6	2.1	-1.0	1.5
Medication: Lisinopril	1.1	1.4	2.0	-1.4	0.9
Alcohol drinker status: Never	1.1	1.3	2.1	-1.5	-0.8
Schizophrenia vs Biploar Disorder	1.0	1.3	2.4	-1.5	-0.5
Average weekly spirits intake	1.0	1.3	2.2	1.5	0.6
Medication: Co-codamol	1.0	1.2	2.0	-1.4	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.2	-0.1	-1.8
Hair/balding pattern: Pattern 4	1.0	2.4	4.3	-2.1	0.7
Headache pain in last month	1.0	1.7	3.2	0.3	-1.8
Number of full brothers	1.0	1.3	2.6	0.2	1.6
Shortness of breath walking on level ground	1.0	1.2	1.2	-1.1	-1.1
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.5	-1.6	0.1
Supplements: Vitamin C	1.0	1.2	2.4	1.6	-0.2
Diastolic blood pressure, automated reading	1.0	3.1	3.2	-1.7	1.8
Crohns Disease (2017)	0.9	2.0	3.6	1.9	0.6
Neuroticism (2016)	0.9	1.3	2.1	1.5	-0.7
Hearing difficulty/problems: Yes	0.9	1.3	1.6	-1.3	-1.0
Medication: Levothyroxine sodium	0.9	1.6	2.2	0.9	-1.5
Neuroticism score	0.9	2.0	3.6	1.9	-0.5
Noisy workplace	0.9	1.1	1.4	-0.8	1.2
Standing height	0.9	8.9	9.7	-2.8	-3.1
Angina (self-reported)	0.9	1.2	2.3	1.5	0.3
Suffer from ‘nerves’	0.9	1.3	2.5	0.4	1.6
Long-standing illness, disability or infirmity	0.9	1.4	1.9	-1.4	-1.0
Leg fat percentage (left)	0.9	3.3	6.4	2.5	0.5
Verbal and Numeric Reasoning (VNR)	0.8	2.0	2.8	-1.1	1.7
Neuroticism	0.8	1.9	2.5	1.6	-1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.0	-1.0	0.9
Comparative body size at age 10	0.8	2.1	4.2	-2.0	0.2
Wheeze or whistling in the chest in last year	0.8	1.4	2.8	0.2	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.7	1.3	-0.3
Medication: Aspirin	0.8	1.1	2.1	0.2	-1.5
Illnesses of siblings: Diabetes	0.8	1.0	1.6	0.7	1.3
Friendships satisfaction	0.8	1.0	1.9	0.1	1.4
Average weekly beer plus cider intake	0.8	1.2	1.9	1.4	0.7
Heart disease (siblings)	0.8	1.0	1.1	1.0	1.0
Breast Cancer	0.7	1.6	2.5	1.6	-0.8
Schizophrenia (2014)	0.7	1.6	3.1	-0.2	1.8
Allergy or Eczema	0.7	1.8	3.6	0.3	-1.9
Sensitivity / hurt feelings	0.7	1.2	2.5	1.6	-0.1
Angina	0.7	1.0	1.9	1.4	0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.5	1.2	0.3
Worrier / anxious feelings	0.7	1.4	2.5	-0.5	-1.6
Number of live births	0.7	1.0	1.8	1.4	-0.3
Depression (self-reported)	0.7	0.8	1.0	-0.7	-1.0
Glaucoma (self-reported)	0.7	0.8	0.9	0.8	1.0
Exposure to tobacco smoke outside home	0.7	1.0	1.6	-1.3	0.6
Knee pain experienced in last month	0.7	1.2	2.1	-1.5	0.4
Fasting Glucose	0.6	0.8	1.0	1.0	0.8
Blood Platelet Count	0.6	6.8	10.8	-3.3	1.7
Chronotype (morning person)	0.6	1.4	2.7	0.4	1.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.3	0.6	-1.1
Diabetes (mother)	0.6	0.8	0.9	0.9	0.9
Taking other prescription medications	0.6	1.0	1.4	-1.2	-0.7
High blood pressure	0.6	1.6	2.5	-1.6	0.8
Fluid intelligence score	0.6	1.2	1.5	-1.2	1.0
Illnesses of siblings	0.6	0.9	1.0	0.8	-1.0
Weight	0.6	3.0	5.3	-2.3	-0.9
Arm fat percentage (right)	0.6	2.5	2.8	1.7	1.5
Hip circumference	0.6	2.6	5.2	-2.3	-0.2
Happiness	0.6	0.8	0.8	0.9	0.9
Asthma	0.6	1.2	2.0	0.6	-1.4
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.2	-1.1	-0.8
High blood pressure (siblings)	0.6	0.8	0.8	-0.9	0.9
Pulse rate, automated reading	0.6	2.1	3.7	-1.9	-0.7
Hypertension (Self-reported)	0.6	1.7	2.2	-1.5	1.1
Smoking status: Previous	0.6	0.9	1.6	-0.6	1.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	0.9	0.7	-1.0
Mood swings	0.6	1.1	2.2	1.5	-0.3
Eye problems/disorders: Cataract	0.6	0.7	1.1	-0.4	-1.1
Number of self-reported non-cancer illnesses	0.6	1.1	1.9	-1.4	-0.6
Miserableness	0.6	1.1	1.7	1.3	-0.7
Number of operations (self-reported)	0.6	0.9	1.8	-1.3	0.3
Commuting to job workplace: Cycle	0.6	0.8	1.3	-1.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.4	1.2	0.5
Irritable Bowel Disease (IBD)	0.5	1.2	1.4	1.2	1.0
Age at First Birth	0.5	0.7	1.4	-0.2	-1.2
HDL Cholesterol	0.5	0.8	1.7	-1.3	0.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.2	1.1	0.8
Number of treatments/medications taken	0.5	0.8	1.0	-0.8	1.0
Current tobacco smoking	0.5	0.8	1.3	1.2	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.4	-0.3	1.5
Pain all over the body in last month	0.5	0.5	0.7	-0.6	0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	0.1	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.2	-0.4	-1.1
Loneliness, isolation	0.5	0.7	1.4	-0.1	-1.2
Asthma (self-reported)	0.5	1.0	1.8	0.5	-1.3
Osteoporosis (self-reported)	0.5	0.6	1.1	-1.0	-0.3
Hearing aid user	0.5	0.6	1.0	-0.4	-1.0
Financial situation satisfaction	0.5	0.6	1.1	-0.3	-1.0
Eye problems/disorders: Glaucoma	0.5	0.5	0.8	0.9	-0.5
Depressed Affect (Nagel 2018)	0.4	0.9	1.3	1.1	-0.7
Neuroticism (Nagel 2018)	0.4	0.9	1.5	1.2	-0.6
Worry (Nagel 2018)	0.4	0.8	1.4	-0.4	-1.2
HbA1C	0.4	0.5	0.9	-1.0	0.2
Primary Biliary Cirrhosis	0.4	0.6	0.7	0.7	0.8
Ulcerative Colitis	0.4	0.6	1.1	0.3	1.0
Systolic Blood Pressure	0.4	1.8	3.2	0.7	1.8
Systolic blood pressure, automated reading	0.4	1.3	2.5	0.2	1.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	0.5	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	0.7	-0.6	-0.9
Pulse rate	0.4	0.7	1.4	-1.2	0.1
Blood clot in the leg (DVT)	0.4	0.5	0.8	0.9	0.4
Age at first live birth	0.4	0.6	1.2	-1.1	0.0
Emphysema/chronic bronchitis	0.4	0.4	0.8	0.9	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.8	0.3	0.9
Arm fat percentage (left)	0.4	1.6	1.9	1.4	1.2
Commuting to job workplace: Public transport	0.4	0.5	0.8	-0.5	-0.9
Unable to work because of sickness or disability	0.4	0.5	1.0	0.1	-1.0
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.2	1.5	-0.1
Alcohol drinker status: Previous	0.4	0.4	0.8	-0.1	0.9
Ulcerative Colitis (UC)	0.3	0.5	1.1	-0.0	1.0
Prostate Cancer	0.3	0.4	0.7	0.9	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	0.8	-0.2
Triglycerides	0.3	0.4	0.8	0.9	0.1
Blood White Count	0.3	2.6	3.8	1.1	-1.9
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.6	0.4	-0.8
Vitamin and mineral supplements	0.3	0.4	0.7	0.8	0.4
Supplements: Zinc	0.3	0.3	0.5	-0.3	-0.7
Medication: Metformin	0.3	0.4	0.7	0.8	0.3
Hand grip strength (right)	0.3	0.8	1.5	1.2	0.3
Fed-up feelings	0.3	0.5	0.6	0.6	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.3	-0.1	1.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	0.9	-0.1
Heart attack	0.3	0.4	0.7	0.9	0.1
Medication: Simvastatin	0.3	0.5	0.9	0.9	0.4
Father’s age at death	0.3	0.5	0.6	-0.8	0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.1	-1.1	-0.2
Pulse wave reflection index	0.3	0.4	0.4	-0.7	0.6
Health satisfaction	0.3	0.4	0.7	0.8	0.4
Eye problems/disorders: None of the above	0.3	0.3	0.6	0.0	0.8
Medication for pain relief, constipation, heartburn	0.3	0.5	0.5	0.6	0.7
Age at last live birth	0.3	0.4	0.7	-0.3	-0.8
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	0.7	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.3	0.6	0.5
Back pain experienced in last month	0.3	0.4	0.5	-0.7	-0.7
Risk taking	0.3	0.5	0.9	1.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.5	-0.7	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.9	0.0
Depression (Nagel 2018)	0.2	0.2	0.5	0.2	-0.7
Lupus	0.2	0.3	0.6	-0.1	-0.8
Blood Red Count	0.2	2.3	3.1	1.8	-1.3
Respiratory disease	0.2	0.4	0.6	-0.3	-0.8
Lung FEV1/FVC ratio	0.2	0.8	1.6	1.2	-0.2
Tanning	0.2	2.6	3.8	1.2	1.9
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.7	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.2	-0.8
Medication: Atenolol	0.2	0.3	0.5	0.3	0.7
Body mass index (BMI)	0.2	0.9	1.4	-1.2	0.7
Trunk fat mass	0.2	0.7	1.4	1.2	0.1
Past tobacco smoking	0.2	0.3	0.3	0.6	-0.5
Nervous feelings	0.2	0.4	0.4	0.6	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	0.6	-0.8	-0.4
Falls in the last year	0.2	0.3	0.4	0.7	0.5
Loud music exposure frequency	0.2	0.3	0.5	0.7	0.1
Birth weight	0.2	0.4	0.6	-0.8	-0.3
Pulse wave peak to peak time	0.2	0.2	0.2	-0.5	-0.5
Medication: Ibuprofen	0.2	0.2	0.3	-0.2	-0.6
Medication: Omeprazole	0.2	0.2	0.5	-0.7	0.1
Leg pain on walking	0.2	0.3	0.3	-0.5	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.4	-0.3	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.0	-0.7
Medication: Gliclazide	0.2	0.3	0.6	-0.1	-0.7
Smoking status: Current	0.2	0.3	0.3	0.5	-0.5
Mother’s age at death	0.2	0.2	0.4	-0.6	-0.2
High cholesterol (Self-reported)	0.2	0.3	0.4	0.5	0.6
Ever smoked	0.2	0.3	0.4	-0.4	0.7
Irritability	0.2	0.4	0.6	0.3	-0.8
Age started oral contraceptive pill	0.2	0.2	0.2	-0.5	0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.0	-0.5
Blood Eosinophil Count	0.1	0.8	1.6	-0.2	1.2
Heel T-Score	0.1	1.1	2.2	-1.5	0.1
Smoking Status	0.1	0.2	0.2	0.3	-0.5
Cardiovascular Disease	0.1	0.3	0.6	-0.7	0.1
Hair Pigment	0.1	2.1	3.6	0.7	1.9
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.5	0.2
Diabetes (self-reported)	0.1	0.1	0.3	0.0	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.2	-0.5
Prospective memory result	0.1	0.1	0.2	-0.4	-0.1
Lung cancer (father)	0.1	0.1	0.1	0.4	-0.1
Illnesses of mother	0.1	0.1	0.1	0.3	0.2
Length of working week for main job	0.1	0.1	0.2	-0.2	-0.5
Exposure to tobacco smoke at home	0.1	0.1	0.1	0.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.1	0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.4	0.3
Gout (self-reported)	0.1	0.1	0.2	0.4	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.4	-0.2
Qualifications: College or University degree	0.1	0.3	0.4	-0.6	-0.4
Migraine (self-reported)	0.1	0.2	0.2	0.3	-0.5
Medication: Seretide 50 evohaler	0.1	0.2	0.3	0.5	0.1
Whole body fat mass	0.1	0.5	1.0	1.0	0.1
Leg fat mass (right)	0.1	0.3	0.5	0.7	-0.3
Alcohol intake frequency.	0.1	0.2	0.3	-0.2	0.5
Overall health rating	0.1	0.2	0.3	-0.2	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.1	0.4
Average weekly red wine intake	0.1	0.2	0.3	-0.2	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.2	0.5	0.4
Cholesterol lowering medication	0.1	0.1	0.1	-0.3	-0.3
Supplements: Calcium	0.1	0.1	0.1	0.3	-0.3
Major Depression (MDD)	0.0	0.0	0.1	-0.3	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.2	0.2
BMI	0.0	0.2	0.3	-0.6	0.4
Qualifications: CSEs or equivalent	0.0	0.0	0.0	-0.0	-0.2
Multivitamins +/- minerals	0.0	0.0	0.0	-0.2	0.0
Waist circumference	0.0	0.2	0.3	-0.5	-0.2
Had menopause	0.0	0.0	0.0	0.1	0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	-0.1	-0.0
Pulse wave Arterial Stiffness index	0.0	0.1	0.1	0.3	0.1
Arm fat mass (right)	0.0	0.1	0.3	-0.1	0.5
Tense / ‘highly strung’	0.0	0.0	0.0	0.1	0.2
Medication: Blood pressure	0.0	0.0	0.1	0.0	0.2
Medication: Allopurinol	0.0	0.1	0.1	-0.4	-0.0
Commuting to job workplace: Walk	0.0	0.0	0.0	0.2	0.1
Arm fat mass (left)	0.0	0.1	0.2	-0.3	0.4
Myopia	0.0	0.0	0.1	-0.2	0.1
Leg fat mass (left)	0.0	0.1	0.1	0.3	-0.1

Hub : Genes

RAVER1

Models

Trait associations