Best TWAS P=2.05e-23 · Best GWAS P=2.42e-23 conditioned to 0.00181
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ECE2 | 0.24 | 0.20 | bslmm | 542 | 0.19 | 1.6e-22 | -9.2 | -9.1 | 6.7e-20 | -0.34 | 0.48 | 0.52 | FALSE |
| 2 | GTEx | Artery Tibial | PSMD2 | 0.13 | 0.09 | lasso | 5 | 0.08 | 1.3e-06 | 5.8 | -6.1 | 1.1e-09 | -0.52 | 0.86 | 0.04 | FALSE |
| 3 | GTEx | Brain Putamen basal ganglia | ECE2 | 0.38 | 0.03 | enet | 22 | 0.11 | 1.4e-03 | -9.3 | -7.6 | 3.0e-14 | -0.28 | 0.07 | 0.25 | FALSE |
| 4 | GTEx | Esophagus Mucosa | ABCF3 | 0.11 | 0.10 | lasso | 3 | 0.08 | 3.6e-06 | 7.1 | -7.2 | 6.7e-13 | -0.26 | 0.65 | 0.20 | FALSE |
| 5 | GTEx | Heart Left Ventricle | DVL3 | 0.18 | 0.13 | enet | 5 | 0.11 | 1.8e-06 | -5.0 | -5.5 | 5.1e-08 | -0.25 | 0.96 | 0.01 | FALSE |
| 6 | GTEx | Pancreas | ECE2 | 0.26 | 0.04 | enet | 24 | 0.09 | 1.2e-04 | -9.3 | -5.5 | 4.7e-08 | -0.21 | 0.14 | 0.18 | FALSE |
| 7 | GTEx | Pituitary | ECE2 | 0.52 | 0.30 | lasso | 7 | 0.23 | 1.5e-06 | -9.3 | -7.6 | 3.2e-14 | -0.28 | 0.25 | 0.50 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | ABCF3 | 0.15 | 0.10 | lasso | 4 | 0.11 | 1.1e-06 | -6.9 | -6.6 | 4.0e-11 | -0.22 | 0.76 | 0.06 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | ABCF3 | 0.13 | 0.08 | lasso | 4 | 0.11 | 1.6e-09 | -6.9 | -8.9 | 6.2e-19 | -0.33 | 0.96 | 0.03 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | PSMD2 | 0.13 | 0.14 | lasso | 4 | 0.15 | 1.4e-12 | 5.8 | -5.9 | 3.4e-09 | -0.50 | 1.00 | 0.00 | FALSE |
| 11 | METSIM | Adipose | ABCF3 | 0.19 | 0.14 | enet | 20 | 0.16 | 1.8e-22 | -3.0 | -5.4 | 7.5e-08 | -0.10 | 1.00 | 0.00 | FALSE |
| 12 | METSIM | Adipose | DVL3 | 0.05 | 0.05 | lasso | 2 | 0.05 | 9.2e-08 | -5.4 | -5.4 | 8.4e-08 | -0.23 | 1.00 | 0.00 | FALSE |
| 13 | YFS | Blood | PSMD2 | 0.26 | 0.22 | lasso | 5 | 0.24 | 2.4e-77 | 5.7 | -5.6 | 1.9e-08 | -0.49 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ABCF3 | 0.04 | 0.00 | enet | 10 | 0.02 | 1.2e-04 | -6.9 | -5.5 | 2.9e-08 | -0.16 | 0.01 | 0.98 | FALSE |
| 15 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | VWA5B2 | 0.15 | 0.00 | blup | 52 | 0.01 | 1.4e-01 | -3.6 | -5.6 | 2.2e-08 | -0.17 | 0.01 | 0.09 | FALSE |
| 16 | The Cancer Genome Atlas | Colon Adenocarcinoma | ABCF3 | 0.07 | 0.00 | blup | 51 | 0.01 | 4.4e-02 | -7.0 | -6.5 | 1.1e-10 | -0.25 | 0.01 | 0.87 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ECE2 | 0.04 | 0.02 | blup | 61 | 0.03 | 3.5e-04 | -9.3 | -8.2 | 2.3e-16 | -0.22 | 0.37 | 0.33 | FALSE |
| 18 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ABCF3 | 0.08 | 0.03 | blup | 51 | 0.06 | 6.1e-04 | -2.8 | -6.5 | 7.3e-11 | -0.22 | 0.01 | 0.78 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | PSMD2 | 0.09 | 0.02 | blup | 50 | 0.05 | 1.2e-06 | 10.0 | -9.6 | 1.0e-21 | -0.78 | 0.00 | 0.99 | TRUE |
| 20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CAMK2N2 | 0.04 | 0.01 | enet | 8 | 0.03 | 3.9e-04 | -3.7 | -7.1 | 1.1e-12 | -0.25 | 0.14 | 0.04 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMD2 | 0.05 | 0.00 | enet | 10 | 0.01 | 3.6e-02 | -9.3 | -6.1 | 1.0e-09 | -0.47 | 0.01 | 0.08 | FALSE |
| 22 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | VWA5B2 | 0.10 | 0.04 | blup | 51 | 0.04 | 1.8e-02 | -7.0 | 10.0 | 2.1e-23 | 0.37 | 0.02 | 0.55 | TRUE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | ABCF3 | 0.05 | 0.02 | lasso | 9 | 0.01 | 1.4e-02 | -3.8 | -5.8 | 5.2e-09 | -0.21 | 0.01 | 0.98 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | DVL3 | 0.02 | 0.01 | blup | 53 | 0.02 | 3.8e-03 | -2.3 | 5.2 | 2.5e-07 | 0.24 | 0.03 | 0.25 | FALSE |