Hub : Genes

DVL3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1620	0.0380	5.0e-07	0.083	NA	0.136	NA	0.143	7.8e-07	NA	2.2e-10	NA	7.3e-11
2	GTEx	Heart Left Ventricle	0.1764	0.0589	2.7e-04	0.127	NA	0.110	NA	0.107	2.8e-07	NA	1.8e-06	NA	2.6e-06
3	METSIM	Adipose	0.0471	0.0202	2.8e-03	0.054	0.018	0.043	0.036	0.048	1.7e-08	7.2e-04	4.2e-07	3.1e-06	9.2e-08
4	YFS	Blood	0.0419	0.0142	2.2e-06	0.001	0.019	0.015	0.020	0.007	1.6e-01	4.3e-07	8.0e-06	2.7e-07	1.9e-03
5	TCGA	Thyroid Carcinoma	0.0230	0.0130	8.8e-03	0.008	0.021	0.004	NA	0.008	5.3e-02	3.8e-03	1.3e-01	NA	5.1e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.3	2.7	-1.6	-1.3	0.0	1.1	0.8
Bipolar Disorder or Schizophrenia	1.0	2.4	6.3	-1.0	-1.3	0.0	2.5	1.7
Depressed Affect (Nagel 2018)	1.6	3.5	7.2	-2.7	-2.5	0.0	-1.9	-0.6
Depression (Nagel 2018)	1.3	1.9	5.4	-2.0	-2.3	0.0	-0.5	-0.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.0	1.1	0.7	0.0	0.6	1.7
Neuroticism (Nagel 2018)	0.8	1.9	4.8	-2.2	-1.8	0.0	-1.0	-0.7
Schizophrenia (2018)	0.8	1.6	5.4	0.0	-0.6	0.0	2.3	1.6
Schizophrenia vs Biploar Disorder	0.4	0.6	1.9	0.2	-0.0	0.0	0.9	1.4
Worry (Nagel 2018)	1.0	2.2	5.4	-2.3	-2.1	0.0	-0.9	0.6
Alzheimer’s Disease (in mother)	0.6	0.7	2.2	0.6	0.5	0.4	1.5	0.6
Alzheimer’s Disease (in father)	2.2	2.4	3.8	-1.9	-1.8	-1.9	-0.5	1.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.1	-0.0	-0.4	-0.8	1.1	0.8
Crohns Disease (2017)	2.6	5.7	9.1	1.8	2.4	2.5	-2.1	-3.0
Irritable Bowel Disease (IBD)	1.7	4.0	5.6	1.8	2.4	2.2	-1.5	-1.9
Ulcerative Colitis (UC)	0.3	0.6	1.2	0.7	1.1	0.9	-0.6	-0.3
Major Depression (MDD)	0.5	0.7	1.6	-1.0	-1.3	0.0	-0.4	-0.8
Reaction Time	1.6	3.0	3.5	1.9	1.4	1.7	1.8	1.9
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.0	1.0	1.0	0.4	-0.3	0.1
Breast Cancer	0.2	0.5	1.1	-1.0	-0.8	-0.8	-0.3	0.2
Ovarian Cancer	0.6	0.8	1.4	0.8	0.9	1.2	0.2	1.0
Prostate Cancer	1.0	1.4	2.8	-1.4	-1.0	-0.5	-1.7	-1.0
Age at First Birth	1.1	1.6	2.4	-0.9	-1.6	-1.4	-1.2	1.1
Bipolar Disorder (2011)	0.0	0.0	0.2	0.0	0.2	0.0	0.4	0.0
Body Mass Index (BMI) (2010)	0.3	0.5	1.6	0.4	0.7	0.0	1.3	-0.1
Coronary Artery Disease (CAD)	1.6	1.9	4.3	1.3	1.3	0.0	-2.1	-1.4
Crohns Disease (2012)	4.2	6.7	8.6	1.9	2.7	2.5	-2.8	-2.9
Mean Putamen Volume	7.6	8.7	13.1	-3.3	-3.5	-3.6	-1.3	2.3
Fasting Glucose	0.8	1.0	1.6	-1.2	-1.3	-1.2	0.4	0.7
HbA1C	0.7	0.8	1.8	-0.6	-0.5	-0.6	-1.3	-1.0
HDL Cholesterol	2.3	3.9	5.4	-2.0	-2.3	-2.3	-0.8	2.0
LDL Cholesterol	0.1	0.1	0.2	0.3	-0.3	-0.5	-0.4	-0.3
Lupus	0.1	0.2	0.5	-0.7	-0.1	0.0	-0.7	0.0
Neuroticism (2016)	0.8	1.2	2.2	-1.1	-1.5	-1.4	0.1	0.7
Primary Biliary Cirrhosis	4.3	6.1	7.8	2.4	2.6	2.8	-1.9	-2.5
Rheumatoid Arthritis	0.5	0.7	2.6	-0.6	-0.5	0.0	-1.6	-0.3
Schizophrenia (2014)	0.3	0.8	2.0	-0.3	-0.6	0.0	1.4	1.2
Triglycerides	2.6	4.2	7.8	2.0	2.2	2.0	0.8	-2.8
Type 2 Diabetes (T2D) (2012)	5.6	6.5	8.1	2.8	2.8	2.8	-2.2	-2.0
Ulcerative Colitis	1.9	2.8	4.8	2.1	2.2	1.9	-0.8	-0.7
Blood Eosinophil Count	0.5	3.7	14.3	-1.2	-0.9	-0.5	-3.8	-1.4
Blood Platelet Count	3.0	34.6	110.2	-4.2	-4.1	-3.9	-10.5	-3.5
Blood Red Count	1.3	12.4	23.3	4.8	4.5	4.1	0.8	-1.1
Blood White Count	0.9	6.9	10.8	-3.2	-3.3	-2.6	-2.6	-0.0
Heel T-Score	0.2	1.4	2.5	1.3	1.3	1.1	1.6	0.2
BMI	0.5	2.8	5.2	1.3	1.9	2.3	1.6	-1.1
Height	1.3	24.5	76.9	3.0	3.5	3.3	-8.8	-3.6
Waist Hip Ratio (WHR)	1.4	6.5	11.2	-3.4	-3.0	-2.6	-2.3	-0.1
Systolic Blood Pressure	1.2	6.0	20.6	-1.8	-1.6	-1.9	4.5	0.0
Smoking Status	2.4	5.8	15.7	-0.0	0.6	0.4	-3.6	-4.0
Allergy or Eczema	0.3	0.9	1.7	-1.2	-1.0	-1.3	-0.5	0.3
Cardiovascular Disease	0.6	2.0	7.4	-0.7	-0.4	-0.6	1.3	-2.7
Hypothyroidism (self reported)	0.1	0.1	0.6	-0.1	0.0	0.0	0.8	0.1
Respiratory disease	0.5	1.1	3.2	0.8	0.9	0.9	-0.4	-1.8
Type 2 Diabetes (T2D) (2018)	3.4	6.4	9.5	3.1	2.8	3.0	0.6	-2.4
Lung FEV1/FVC ratio	0.1	0.4	0.5	0.7	0.4	0.7	0.7	-0.2
Lung FVC	0.2	0.9	1.8	0.8	1.3	1.2	-0.6	-0.4
Neuroticism	1.2	3.0	6.0	-2.4	-2.1	-1.5	-1.5	-0.5
Chronotype (morning person)	0.9	2.2	10.4	-0.4	0.1	0.2	-3.2	0.4
Hair Pigment	0.0	0.5	1.8	-0.4	-0.6	-0.2	1.4	0.6
Tanning	0.0	0.2	0.3	-0.2	0.3	0.6	0.2	-0.5
Hand grip strength (left)	1.2	3.2	11.2	0.1	0.6	0.4	-3.3	-2.1
Number of treatments/medications taken	0.1	0.2	0.4	-0.5	-0.4	-0.6	0.1	-0.7
Average weekly spirits intake	1.8	2.3	3.9	2.0	1.7	1.9	1.1	0.1
Sensitivity / hurt feelings	0.2	0.3	1.3	0.0	0.3	0.5	1.2	0.1
Frequency of depressed mood in last 2 weeks	1.7	2.3	4.0	-1.8	-2.0	-1.6	-0.9	-0.9
Hearing difficulty/problems: Yes	0.0	0.0	0.1	-0.0	-0.0	0.3	0.3	0.1
Relative age of first facial hair	4.0	8.2	12.2	-3.5	-3.3	-3.0	1.0	2.8
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	4.8	-0.6	0.3	0.7	-0.6	-2.2
Ever used hormone-replacement therapy (HRT)	1.7	2.1	8.7	-0.0	-0.1	-0.3	-3.0	1.4
Ever had hysterectomy (womb removed)	0.8	1.0	3.5	0.5	-0.0	-0.0	1.0	1.9
Systolic blood pressure, automated reading	0.6	1.8	8.4	-0.6	-0.4	-0.5	2.9	-0.1
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	4.6	1.7	1.8	2.1	0.2	-1.6
Angina	1.4	1.8	2.5	1.6	1.3	1.4	-0.4	-1.6
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.5	-0.2	-0.5	0.0	0.2
Vitamin and mineral supplements	1.4	1.9	4.8	-0.9	-1.0	-1.1	2.2	1.3
Supplements: Zinc	1.9	2.1	3.2	-1.8	-1.5	-1.6	-1.4	-0.4
Medication: Co-codamol	0.6	0.7	1.3	-1.1	-1.0	-0.8	-0.3	-0.6
Medication: Metformin	2.0	2.8	5.2	2.3	1.8	1.7	1.3	-0.9
Diabetes (father)	0.8	1.0	3.5	0.3	0.5	0.6	-0.9	-1.9
Diabetes (mother)	0.3	0.4	1.4	0.5	-0.2	-0.3	1.2	0.0
Severe depression (siblings)	0.4	0.4	0.9	-0.5	0.5	0.6	-1.0	-0.4
Pack years adult smoking proportion	0.5	0.8	2.5	0.0	0.2	0.3	1.2	-1.6
Impedance of leg (right)	3.6	17.6	23.3	-3.5	-4.8	-4.7	2.8	4.7
Leg fat-free mass (left)	2.7	14.3	18.1	3.0	4.2	4.2	-3.4	-3.9
Trunk fat percentage	0.5	1.8	3.0	-1.1	-1.1	-0.8	1.7	1.7
Hand grip strength (right)	1.8	4.8	12.0	0.3	1.0	0.7	-3.5	-3.2
Townsend deprivation index at recruitment	0.3	0.5	1.8	0.4	0.1	0.3	-0.5	-1.3
Current tobacco smoking	0.1	0.1	0.4	0.1	-0.3	-0.6	-0.2	-0.4
Average weekly fortified wine intake	0.1	0.1	0.2	0.1	0.2	0.4	0.1	0.4
Maternal smoking around birth	2.8	4.0	7.1	-2.7	-2.5	-2.2	-0.2	1.1
Fed-up feelings	1.6	2.9	4.1	-1.9	-1.7	-0.9	-2.0	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	4.1	-0.9	-0.8	-0.5	-0.4	-2.0
Relative age voice broke	1.8	2.7	5.6	-2.4	-1.8	-1.6	-1.4	0.5
Taking other prescription medications	0.5	0.8	1.7	-1.3	-1.1	-1.0	-0.2	0.1
Age when periods started (menarche)	0.5	1.2	5.9	0.2	0.4	0.2	-0.2	-2.4
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.5	-0.1	-0.0	0.2	1.3	1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	3.8	-1.4	-1.4	-1.4	2.0	1.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.2	-0.4	-1.1	-1.1	0.9	0.8
Qualifications: CSEs or equivalent	0.1	0.1	0.3	0.0	0.2	0.3	0.4	-0.6
Serious illness, injury or assault to yourself	0.1	0.2	0.6	-0.8	-0.3	-0.0	-0.0	-0.0
High blood pressure	0.5	1.3	2.9	-0.9	-0.8	-0.9	1.7	-1.2
Hayfever, allergic rhinitis or eczema	1.4	3.1	4.9	-2.0	-2.0	-2.2	-0.4	1.4
Multivitamins +/- minerals	3.6	4.5	9.7	1.6	1.6	1.6	-3.1	-2.3
Stomach or abdominal pain in last month	1.4	1.7	4.8	0.7	1.2	1.2	0.4	-2.2
Supplements: Glucosamine	0.5	0.6	2.1	-0.4	-0.3	0.0	-1.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.8	-1.4	-0.7	-0.6	1.3	1.0
Medication: Atenolol	0.1	0.1	0.5	-0.1	0.1	-0.2	-0.2	-0.7
Medication: Levothyroxine sodium	0.4	0.7	1.3	-1.1	-0.6	-0.6	1.1	0.6
Sitting height	1.3	9.2	18.4	2.0	2.5	2.4	-4.3	-3.5
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	0.1	-0.4	-0.7	1.2	1.1
High blood pressure (mother)	0.5	0.7	2.6	0.1	0.3	0.5	1.6	-0.6
Body mass index (BMI)	0.4	1.9	3.9	1.0	1.7	2.0	0.8	-0.9
Impedance of leg (left)	4.6	22.1	29.7	-4.0	-5.5	-5.4	3.0	5.2
Leg predicted mass (left)	2.6	13.9	17.5	3.0	4.1	4.2	-3.4	-3.8
Trunk fat mass	0.0	0.1	0.3	-0.0	0.3	0.6	0.2	0.1
Waist circumference	0.1	0.2	0.6	-0.3	0.1	0.5	-0.8	-0.4
Number of incorrect matches in round	0.3	0.6	1.3	-1.1	-0.9	-0.7	0.5	0.3
Past tobacco smoking	2.6	4.7	17.1	0.7	0.2	0.2	4.1	2.5
Alcohol usually taken with meals	1.7	2.7	5.0	-1.3	-1.9	-1.8	-0.2	2.2
Nervous feelings	0.9	1.7	3.6	-1.9	-1.5	-1.4	0.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	2.5	-1.6	-1.5	-0.9	-1.0	-0.3
Hearing difficulty/problems with background noise	0.5	0.7	2.9	0.6	0.3	0.2	1.7	0.6
Hair/balding pattern: Pattern 2	0.0	0.1	0.1	0.3	0.1	0.1	-0.3	0.4
Had menopause	0.6	0.8	1.2	1.0	1.1	0.8	-1.0	0.1
Had other major operations	0.7	0.9	2.4	-0.7	-0.8	-0.7	-0.7	1.5
Forced vital capacity (FVC)	0.4	1.5	4.2	0.2	0.8	0.6	-2.0	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.1	-1.3	-1.5	-1.4	1.0	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.8	0.7	0.6	0.7	-0.5	-0.9
Qualifications: None of the above	0.7	1.6	2.8	-1.7	-1.6	-1.5	-0.4	0.1
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.4	-0.7	-0.8	0.2	0.3
Mouth/teeth dental problems	0.5	0.7	1.4	-0.8	-1.1	-1.2	0.0	0.4
Heart attack	1.8	2.3	4.4	2.1	1.7	1.9	-0.1	-1.0
Allergy	0.4	0.9	2.2	1.5	1.1	1.0	0.3	-0.1
Pain all over the body in last month	0.2	0.2	0.5	-0.2	-0.1	-0.1	0.7	0.7
Diabetes (self-reported)	4.1	6.3	9.4	3.1	2.7	2.7	-0.5	-2.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	1.0	-0.7	-0.8	-1.0	0.2	0.2
Medication: Ramipril	0.3	0.4	0.9	0.9	0.7	0.7	0.4	-0.1
Medication: Simvastatin	1.5	2.3	4.4	1.0	1.1	0.9	-2.0	-2.1
Fluid intelligence score	0.2	0.4	0.5	0.6	0.7	0.4	-0.5	0.7
Illnesses of siblings	0.3	0.5	1.2	-0.2	-0.7	-0.6	-0.5	1.1
Neuroticism score	1.2	2.4	4.4	-2.1	-1.8	-1.3	-1.6	-0.5
Weight	0.9	4.5	7.1	1.8	2.5	2.7	-1.5	-2.0
Impedance of arm (right)	3.4	15.7	22.1	-3.6	-4.5	-4.5	1.8	4.7
Arm fat percentage (right)	0.1	0.6	2.2	-0.4	-0.0	0.4	1.5	0.6
Trunk fat-free mass	3.2	18.4	22.1	3.3	4.3	4.4	-4.6	-4.7
Hip circumference	0.2	1.0	2.3	1.0	1.3	1.5	0.0	-0.1
Time employed in main current job	0.2	0.3	0.9	-0.5	0.3	0.0	-0.1	-0.9
Alcohol intake versus 10 years previously	1.0	1.5	2.9	0.6	1.0	1.1	-1.5	-1.7
Father’s age at death	0.7	0.9	1.6	1.1	1.1	1.3	0.7	-0.2
Worrier / anxious feelings	0.7	1.2	3.8	-1.0	-1.0	-0.5	-1.9	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.9	-0.3	0.4	0.9	-0.9	-1.7
Falls in the last year	0.7	0.9	2.3	-1.1	-0.7	-0.1	1.5	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.6	0.6	0.5	-0.7	0.3
Number of live births	0.4	0.6	2.7	-0.1	0.2	0.2	1.6	-0.2
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.2	0.1	0.4	0.4	-1.8	-0.9
Pulse rate	0.2	0.3	1.1	0.3	-0.5	-0.2	-0.3	1.1
Happiness	0.2	0.2	0.5	0.6	0.5	0.7	0.1	-0.5
Noisy workplace	0.3	0.4	0.7	-0.8	-0.1	0.2	-0.7	-0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.7	4.0	2.0	1.7	1.2	-0.5	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	6.9	0.2	0.5	0.9	2.6	0.5
Mouth/teeth dental problems: Dentures	1.4	2.3	5.3	1.1	1.4	1.4	-2.3	-1.0
Asthma	0.2	0.5	1.0	-0.6	-0.4	-0.3	1.0	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.8	0.5	-0.1	0.0	0.5	-1.4
Medication: Cholesterol lowering	1.3	2.1	4.1	-1.7	-2.0	-1.7	0.5	0.2
Depression (self-reported)	1.2	1.5	3.6	-1.4	-0.3	0.1	-1.9	-1.2
Medication: Lansoprazole	0.8	0.9	2.8	-0.3	0.4	0.6	-1.0	-1.7
Prospective memory result	0.1	0.2	0.4	0.6	0.3	0.4	-0.2	-0.2
Lung cancer (father)	1.9	2.2	4.9	1.4	0.8	0.9	-2.2	-1.6
Illnesses of mother	1.7	2.0	9.9	0.0	-0.1	-0.5	-3.2	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.8	-0.4	0.1	0.1	-1.4	-0.3
Pulse wave Arterial Stiffness index	1.3	1.5	3.1	-1.8	-1.5	-1.5	0.2	-0.2
Impedance of arm (left)	3.9	17.9	25.8	-3.8	-4.8	-4.8	1.9	5.1
Arm fat mass (right)	0.2	1.0	2.4	0.6	1.3	1.5	-0.0	-0.9
Trunk predicted mass	3.3	18.7	22.4	3.3	4.3	4.4	-4.7	-4.7
Standing height	0.8	8.3	22.6	2.0	2.0	2.0	-4.8	-2.7
Length of working week for main job	0.8	0.9	2.6	0.3	0.6	0.6	1.1	-1.6
Exposure to tobacco smoke at home	0.3	0.3	0.9	-0.4	-0.7	-0.9	0.1	0.4
Breastfed as a baby	0.1	0.2	0.8	-0.2	-0.2	-0.1	-0.1	0.9
Tense / ‘highly strung’	0.3	0.5	0.9	-0.9	-0.8	-0.4	0.7	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.4	-0.7	-0.0	0.1	0.2	-1.6
Hair/balding pattern: Pattern 4	0.6	1.5	2.2	1.1	1.1	1.1	1.5	-1.3
Birth weight of first child	0.2	0.4	0.8	0.9	0.7	0.3	-0.9	-0.4
Peak expiratory flow (PEF)	0.5	1.1	2.6	-0.8	-0.2	-0.0	-1.6	-1.4
Pulse wave reflection index	0.7	0.9	3.7	-0.4	0.4	0.7	0.1	-1.9
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.2	-0.6	-1.1	-0.7	-1.1	-0.3
Loud music exposure frequency	2.0	2.1	3.6	1.9	1.6	1.8	-1.1	-0.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.1	1.6	2.0	1.8	-0.1	-0.9
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.1	0.3	0.1	0.3	-0.0
Blood clot in the leg (DVT)	0.6	0.7	1.4	0.4	0.8	0.9	-1.2	-0.8
Medication: Paracetamol	1.2	1.9	8.6	0.3	0.3	0.2	-0.9	-2.9
Headache pain in last month	0.5	0.8	3.5	-0.1	0.1	0.5	-0.4	-1.9
Medication for cholesterol, blood pressure or diabetes	2.1	3.4	6.3	2.1	2.4	2.5	-0.5	-0.4
Glaucoma (self-reported)	1.0	1.2	1.9	-1.0	-1.0	-0.8	1.4	1.1
Gout (self-reported)	0.7	0.9	3.0	-0.1	-0.1	-0.2	1.7	1.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.6	-0.5	-0.1	-0.0	1.3	0.5
Medication: Amlodipine	0.2	0.2	1.0	-0.2	-0.3	0.2	1.0	-0.1
Medication: Ventolin 100micrograms inhaler	1.1	1.5	3.1	-1.8	-1.1	-1.2	0.6	1.1
Birth weight	0.3	0.6	1.0	0.3	0.8	0.4	-1.0	0.9
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.3	0.1	0.2	-0.1	-0.6
High blood pressure (siblings)	0.7	1.0	2.1	-1.4	-1.1	-1.2	0.5	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.5	1.8	-0.1	0.5	0.3	-1.3	-0.7
Body fat percentage	0.5	1.9	3.5	-1.2	-1.1	-0.8	1.9	1.7
Leg fat percentage (right)	0.4	1.4	4.1	-0.8	-0.7	-0.3	2.0	1.2
Arm fat-free mass (right)	3.2	16.2	19.4	3.3	4.3	4.3	-3.7	-4.4
Exposure to tobacco smoke outside home	0.3	0.4	1.0	1.0	0.7	0.4	-0.3	-0.7
Comparative body size at age 10	0.2	0.6	1.6	-0.3	0.7	0.7	-1.3	-0.6
Number of full brothers	1.0	1.3	2.0	1.4	1.3	1.1	1.1	-0.6
Worry too long after embarrassment	0.9	1.5	3.0	-1.7	-1.3	-0.8	-1.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.6	4.0	-0.2	0.8	1.1	-1.6	-2.0
Wheeze or whistling in the chest in last year	1.1	2.0	7.0	-1.2	-0.6	-0.5	0.9	-2.6
Number of children fathered	0.1	0.1	0.6	-0.2	-0.2	-0.1	-0.8	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	0.5	0.8	0.8	-1.0	-0.1
Age at first live birth	1.4	2.5	3.4	-1.5	-1.7	-1.9	-1.6	1.2
Pulse wave peak to peak time	1.3	1.5	2.8	1.7	1.5	1.5	-0.5	0.3
Health satisfaction	0.2	0.2	0.8	-0.4	-0.4	0.0	0.9	-0.0
Shortness of breath walking on level ground	1.5	1.7	4.4	-2.1	-1.7	-1.0	-0.0	0.6
Qualifications: College or University degree	0.5	1.4	2.7	1.3	1.2	1.2	-1.6	-0.2
Eye problems/disorders: None of the above	0.3	0.3	1.3	-0.3	0.0	-0.0	-1.1	-0.5
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.8	-1.7	-1.1	-1.3	-1.2	0.1
Emphysema/chronic bronchitis	0.4	0.5	0.9	0.3	0.8	0.6	0.9	-0.6
Medication for pain relief, constipation, heartburn	1.3	2.3	8.8	0.0	-0.1	-0.0	1.6	3.0
Neck or shoulder pain in last month	1.8	2.5	3.8	-2.0	-1.6	-1.3	1.6	1.4
Medication: Blood pressure	0.5	0.8	1.2	-1.1	-0.8	-1.0	0.8	-0.7
Angina (self-reported)	0.9	1.2	2.1	1.3	1.0	1.1	-0.4	-1.4
Migraine (self-reported)	0.1	0.1	0.4	0.5	-0.0	-0.1	-0.6	-0.0
Medication: Ibuprofen	0.7	0.9	3.5	0.7	0.5	0.5	0.0	-1.9
Medication: Allopurinol	0.3	0.4	1.0	-0.7	-0.3	-0.4	1.0	0.3
Medication: Omeprazole	0.9	1.1	2.7	-1.3	-0.8	-0.6	-1.6	0.4
Medication: Seretide 50 evohaler	0.6	0.7	2.9	0.3	-0.1	-0.3	-1.7	-0.5
Mean time to correctly identify matches	3.0	5.7	10.0	3.2	2.8	2.9	1.1	1.0
Heart disease (mother)	0.7	0.8	3.5	0.4	0.1	0.4	1.9	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	-0.5	-0.6	-0.9	-0.2	-0.6
Whole body fat mass	0.1	0.4	1.1	0.5	0.7	1.0	0.4	-0.1
Leg fat mass (right)	0.1	0.6	1.5	0.5	0.9	1.2	0.5	-0.3
Arm predicted mass (right)	3.0	15.6	18.7	3.2	4.2	4.2	-3.7	-4.3
Pulse rate, automated reading	2.6	8.4	14.6	-3.0	-3.8	-3.5	0.4	2.5
Alcohol intake frequency.	1.2	2.9	4.7	1.2	2.1	2.2	0.2	-1.9
Comparative height size at age 10	2.1	11.8	14.4	3.2	3.6	3.8	-3.6	-2.8
Number of full sisters	0.6	0.7	1.0	-1.0	-0.9	-0.8	-0.5	-1.0
Suffer from ‘nerves’	0.7	1.1	1.8	-1.2	-1.3	-0.9	-1.1	0.6
Overall health rating	0.3	0.6	2.4	-0.5	-0.3	0.3	1.6	-0.0
Chest pain or discomfort	4.0	5.7	9.1	1.9	2.4	2.5	2.0	-3.0
Had major operations	0.4	0.5	0.7	-0.8	-0.9	-0.6	-0.6	0.5
Age at last live birth	0.8	1.1	4.0	-0.5	-0.6	-0.8	-2.0	0.5
Family relationship satisfaction	0.7	0.9	2.5	0.8	0.8	0.7	-1.6	-0.0
Leg pain on walking	0.1	0.1	0.5	0.1	-0.1	0.2	-0.0	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	0.2	0.4	0.7	0.6	-1.4
Commuting to job workplace: Car/motor vehicle	4.4	5.0	10.9	1.6	2.3	2.4	-0.7	-3.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	3.0	0.7	0.1	-0.2	-1.7	-0.2
Medication: Aspirin	0.5	0.6	1.6	0.6	0.4	0.4	-0.9	-1.3
Supplements: Vitamin C	0.1	0.1	0.3	-0.4	-0.0	0.1	-0.5	-0.2
Knee pain experienced in last month	0.3	0.5	1.3	0.1	0.4	0.7	0.5	-1.1
Hypertension (Self-reported)	0.4	1.1	2.9	-0.6	-0.5	-0.6	1.2	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	8.4	-0.2	0.2	0.5	-2.9	-1.5
Illnesses of father: Heart disease	0.3	0.4	0.9	-0.9	-0.4	-0.4	0.8	0.6
Illnesses of siblings: Diabetes	0.7	0.8	3.1	0.5	0.4	0.4	1.8	0.6
Smoking status: Previous	3.3	4.9	16.7	-0.6	0.2	0.2	-4.1	-2.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	6.1	-0.8	-0.1	-0.1	-2.3	-2.5
Whole body fat-free mass	3.2	18.5	21.4	3.4	4.5	4.6	-4.3	-4.6
Leg fat-free mass (right)	2.9	15.2	18.6	3.1	4.3	4.3	-3.6	-4.1
Arm fat percentage (left)	0.2	0.7	1.8	-0.8	-0.5	-0.1	1.4	0.9
Average weekly red wine intake	2.9	4.3	12.9	-1.1	-1.9	-1.8	0.7	3.6
Handedness (chirality/laterality): Left-handed	2.1	2.6	4.1	2.0	2.0	2.0	-0.9	-0.3
Mood swings	0.4	0.7	2.0	-0.7	-0.6	-0.2	-1.4	-0.9
Loneliness, isolation	0.8	1.1	2.0	-0.9	-1.3	-0.9	-1.4	0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.5	0.3	0.4	0.4	-0.6
Ever had bowel cancer screening	0.7	0.8	2.0	-0.3	0.1	-0.2	-1.3	-1.4
Diabetes diagnosed by doctor	3.9	6.5	10.1	3.2	3.0	2.9	-0.2	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	-0.9	-0.5	-0.5	0.7	-0.4
Friendships satisfaction	0.1	0.2	0.4	0.4	0.3	0.3	0.1	0.6
Qualifications: nursing, teaching	0.5	0.9	1.2	0.7	1.1	0.9	0.7	-1.1
Commuting to job workplace: Walk	0.9	1.0	2.4	-0.4	-1.0	-0.5	1.0	1.5
Eye problems/disorders: Cataract	0.7	0.8	1.4	0.9	0.9	0.7	-0.8	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.9	0.4	0.3	0.1	0.9	-0.2
Medication for cholesterol	0.2	0.4	1.0	-0.1	-0.3	-0.0	-0.8	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.7	-0.3	-0.0	-0.9	-0.4
Back pain experienced in last month	0.7	1.0	3.1	-1.0	-0.4	-0.4	-0.7	-1.8
Mineral and other dietary supplements	1.7	2.3	4.8	-1.0	-1.5	-1.2	1.5	2.2
Breast cancer (self-reported)	0.8	1.0	1.5	0.1	0.8	1.1	-1.2	-1.2
Asthma (self-reported)	0.2	0.3	1.0	-0.4	-0.2	-0.3	0.6	-1.0
Osteoporosis (self-reported)	0.3	0.3	1.5	0.5	0.0	-0.0	0.0	1.2
Osteoarthritis (self-reported)	0.4	0.5	0.8	0.8	0.9	0.7	-0.6	0.0
Medication: Aspirin	0.8	1.0	2.0	1.1	0.9	0.9	-0.6	-1.4
Medication: Gliclazide	0.4	0.5	1.2	1.1	0.7	0.8	0.3	-0.3
Illnesses of father: None of the above (group 1)	0.7	0.9	1.4	1.2	1.1	1.0	-0.4	-0.7
Smoking status: Current	0.2	0.3	0.9	-0.2	-0.6	-1.0	-0.2	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.9	0.8	0.9	1.0	-0.5	-0.1
Whole body water mass	3.2	18.1	20.9	3.3	4.4	4.5	-4.3	-4.6
Leg predicted mass (right)	2.8	15.0	18.3	3.1	4.2	4.3	-3.6	-4.1
Arm fat mass (left)	0.2	0.9	2.1	0.6	1.2	1.4	0.1	-0.8
Number of self-reported non-cancer illnesses	1.3	2.2	7.5	-0.2	0.3	0.2	-1.8	-2.7
Average weekly champagne plus white wine intake	0.8	1.1	3.0	-0.8	-0.9	-0.9	-1.7	0.5
Miserableness	1.1	2.0	4.0	-1.4	-1.2	-1.0	-2.0	-1.1
Guilty feelings	3.1	4.7	12.9	0.4	0.7	1.0	-3.0	-3.6
Wears glasses or contact lenses	0.7	0.8	1.7	-0.6	-0.8	-0.6	-0.9	1.3
Ever taken oral contraceptive pill	0.6	0.7	1.2	-1.0	-0.6	-0.3	-0.9	-1.1
Hearing aid user	0.2	0.3	0.6	-0.2	0.2	0.6	-0.8	-0.4
Mother’s age at death	1.0	1.3	2.9	1.7	1.4	1.2	-0.5	0.0
Financial situation satisfaction	0.1	0.1	0.4	0.2	-0.1	0.2	-0.6	-0.3
Tinnitus: Yes, now most or all of the time	1.5	1.8	4.5	-2.1	-1.4	-1.2	-0.1	1.0
Commuting to job workplace: Public transport	0.4	0.4	1.2	0.7	0.1	0.3	0.6	1.1
Eye problems/disorders: Glaucoma	2.8	3.3	4.1	-1.8	-2.0	-1.7	1.7	1.8
Medication: Blood pressure	0.2	0.4	1.4	0.3	0.0	-0.1	1.2	-0.7
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	-0.2	-0.2	0.0	-0.6	-0.0
Supplements: Fish oil (including cod liver oil)	1.9	2.4	4.2	1.3	1.8	1.3	-1.1	-2.1
High cholesterol (Self-reported)	1.5	2.7	5.4	-1.6	-2.1	-2.3	0.5	1.1
Medication: Bendroflumethiazide	0.2	0.3	1.2	0.1	0.4	0.3	0.5	-1.1
Medication: Paracetamol	1.7	2.6	9.6	1.0	0.9	0.7	-1.0	-3.1
Medication: Lisinopril	0.1	0.2	0.4	0.1	-0.5	-0.6	0.6	0.2
Medication: Atorvastatin	3.7	4.5	7.1	-1.7	-2.7	-2.4	1.8	1.9
Illnesses of father: High blood pressure	0.6	0.7	3.6	0.1	0.2	0.1	1.9	-0.1
Alcohol drinker status: Never	1.0	1.2	2.4	1.3	1.6	1.4	-0.2	-0.5
Ever smoked	2.2	3.9	14.9	-0.3	-0.3	-0.4	-3.9	-2.1
Basal metabolic rate	2.5	14.1	17.0	2.9	4.0	4.1	-3.5	-4.0
Leg fat percentage (left)	0.5	1.7	4.1	-1.1	-1.0	-0.5	2.0	1.4
Arm fat-free mass (left)	2.9	14.5	17.1	3.1	4.0	4.1	-3.6	-4.0
Number of operations (self-reported)	2.2	3.2	4.6	-2.0	-2.1	-1.9	-0.6	1.9
Average weekly beer plus cider intake	2.2	3.2	4.5	-1.9	-2.0	-1.8	2.1	0.7
Irritability	0.6	1.0	2.0	-1.1	-0.9	-0.6	1.4	0.8
Risk taking	1.1	1.6	3.0	-1.2	-1.7	-1.7	-0.7	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.5	0.3	0.2	0.6	-1.2	-0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.4	0.3	0.1	-0.9	-0.5
Age started oral contraceptive pill	1.0	1.3	2.7	0.9	1.6	1.6	0.7	-0.1
Diastolic blood pressure, automated reading	0.8	2.6	12.0	-0.8	-0.4	-0.5	3.5	-0.2
Ever depressed for a whole week	0.4	0.5	0.8	0.7	0.6	0.9	-0.7	-0.8
Unable to work because of sickness or disability	0.3	0.4	0.8	0.4	0.6	0.9	0.7	-0.5
Commuting to job workplace: Cycle	2.8	3.4	6.3	-1.9	-2.3	-2.5	0.2	1.3
Myopia	0.7	1.0	3.3	-1.2	-0.5	-0.4	-1.8	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.8	0.6	0.9	0.9	-1.3	0.5
Cholesterol lowering medication	0.1	0.2	0.4	0.6	0.6	0.3	0.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	6.3	-1.6	-0.7	-0.5	-2.5	-0.6
Pain experienced in last month	0.2	0.4	0.9	0.9	0.7	0.4	-0.6	0.1
Supplements: Calcium	1.2	1.3	5.0	-0.5	-0.6	-0.8	-2.2	0.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.4	0.2	-0.1	-0.6	0.1	0.7
Heart attack/myocardial infarction (self-reported)	2.1	2.7	4.2	2.1	1.8	2.0	-0.6	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.9	0.4	0.9	1.0	-1.4	-1.0
Heart disease (siblings)	1.8	2.2	3.0	1.7	1.6	1.5	-0.5	-1.7
Alcohol drinker status: Previous	0.2	0.2	0.4	0.1	0.5	0.6	-0.1	-0.5
Pack years of smoking	0.5	0.8	2.5	0.3	0.5	0.5	0.9	-1.6
Impedance of whole body	4.2	21.3	27.9	-4.0	-5.3	-5.2	2.9	5.2
Leg fat mass (left)	0.1	0.5	1.3	0.4	0.8	1.1	0.5	-0.3
Arm predicted mass (left)	2.9	14.9	18.8	3.3	4.3	4.3	-3.1	-4.1