Best TWAS P=1.26e-11 · Best GWAS P=1.95e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | GTEx | Thyroid | PAM | 0.07 | 0.08 | lasso | 4 | 0.07 | 5.5e-06 | -6.7 | 6.8 | 1.3e-11 | -0.99 | 0.00 | 1.00 | TRUE |
| 7 | GTEx | Whole Blood | PAM | 0.20 | 0.28 | lasso | 9 | 0.27 | 1.0e-24 | -6.1 | -6.0 | 1.4e-09 | 0.84 | 0.21 | 0.79 | FALSE |
| 11 | YFS | Blood | PAM | 0.64 | 0.68 | enet | 68 | 0.72 | 0.0e+00 | -5.6 | -6.0 | 2.3e-09 | 0.81 | 0.81 | 0.19 | FALSE |
| 8 | METSIM | Adipose | PAM | 0.04 | 0.02 | lasso | 2 | 0.02 | 2.9e-04 | -6.1 | -5.9 | 4.1e-09 | 0.75 | 0.15 | 0.77 | FALSE |
| 4 | GTEx | Nerve Tibial | PAM | 0.06 | 0.04 | lasso | 3 | 0.05 | 3.1e-04 | 3.9 | 5.9 | 4.5e-09 | -0.79 | 0.02 | 0.95 | FALSE |
| 10 | YFS | Blood | GIN1 | 0.02 | 0.04 | lasso | 7 | 0.05 | 5.1e-17 | -4.5 | -5.7 | 1.0e-08 | 0.70 | 0.63 | 0.37 | FALSE |
| 1 | GTEx | Artery Tibial | PPIP5K2 | 0.07 | 0.04 | enet | 22 | 0.05 | 1.4e-04 | -4.8 | 5.6 | 1.7e-08 | -0.75 | 0.09 | 0.90 | FALSE |
| 9 | NTR | Blood | PAM | 0.26 | 0.29 | lasso | 1 | 0.29 | 2.6e-95 | -5.6 | -5.6 | 2.3e-08 | 0.79 | 0.81 | 0.19 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | PAM | 0.04 | 0.00 | lasso | 4 | 0.04 | 2.3e-04 | -5.7 | -5.5 | 4.1e-08 | 0.68 | 0.15 | 0.24 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | PAM | 0.23 | 0.07 | enet | 5 | 0.10 | 2.5e-10 | -6.0 | 5.4 | 7.1e-08 | -0.67 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | PPIP5K2 | 0.09 | 0.01 | lasso | 7 | 0.00 | 2.9e-01 | -4.0 | 5.4 | 7.4e-08 | -0.68 | 0.16 | 0.26 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | PPIP5K2 | 0.11 | 0.10 | lasso | 5 | 0.04 | 2.7e-03 | -4.7 | 5.3 | 1.3e-07 | -0.69 | 0.43 | 0.38 | FALSE |