[Hub]/) : Traits : Impedance of leg (left) :

chr6:33,551,514-36,158,878

Best TWAS P=6.45e-17 · Best GWAS P=3.49e-17 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PACSIN1 0.07 0.01 lasso 6 0.02 1.1e-03 -6.2 -7.6 2.6e-14 0.37 0.32 0.04 FALSE
2 CommonMind Brain Pre-frontal Cortex SNRPC 0.10 0.16 lasso 4 0.15 3.6e-18 -7.2 7.1 8.8e-13 -0.12 0.99 0.01 FALSE
3 CommonMind Brain Pre-frontal Cortex UHRF1BP1 0.17 0.23 lasso 19 0.22 5.8e-27 -7.0 -7.1 1.2e-12 0.11 0.99 0.01 FALSE
4 GTEx Adipose Subcutaneous UHRF1BP1 0.30 0.35 enet 28 0.36 1.6e-30 -7.0 -7.1 1.5e-12 0.11 1.00 0.00 FALSE
5 GTEx Adipose Subcutaneous SNRPC 0.13 0.13 enet 21 0.13 1.2e-10 -7.0 6.1 1.1e-09 -0.03 0.99 0.01 FALSE
6 GTEx Adipose Visceral Omentum UHRF1BP1 0.30 0.34 lasso 3 0.34 3.0e-18 -6.9 -7.0 2.6e-12 0.11 0.99 0.01 FALSE
7 GTEx Adrenal Gland UHRF1BP1 0.32 0.26 enet 33 0.33 1.3e-12 -7.0 -6.1 8.8e-10 0.02 0.51 0.49 FALSE
8 GTEx Artery Aorta UHRF1BP1 0.35 0.32 lasso 10 0.30 7.7e-17 -7.1 -7.4 1.3e-13 0.15 0.98 0.02 FALSE
9 GTEx Artery Aorta SNRPC 0.06 0.03 enet 14 0.02 1.8e-02 -8.2 5.8 5.0e-09 -0.10 0.13 0.50 FALSE
10 GTEx Artery Coronary UHRF1BP1 0.33 0.36 lasso 2 0.35 1.6e-12 -7.0 -7.0 2.2e-12 0.11 0.95 0.05 FALSE
11 GTEx Artery Tibial UHRF1BP1 0.31 0.43 lasso 11 0.43 4.0e-36 -7.0 -6.8 1.4e-11 0.10 1.00 0.00 FALSE
12 GTEx Artery Tibial SNRPC 0.06 0.06 lasso 4 0.05 1.3e-04 -7.1 7.5 7.8e-14 -0.12 0.30 0.69 FALSE
13 GTEx Brain Caudate basal ganglia UHRF1BP1 0.19 0.14 lasso 7 0.12 3.1e-04 -7.0 -6.5 8.8e-11 0.11 0.40 0.07 FALSE
14 GTEx Brain Caudate basal ganglia SNRPC 0.19 0.15 lasso 3 0.06 7.7e-03 -7.0 7.3 3.4e-13 -0.11 0.42 0.08 FALSE
15 GTEx Brain Cerebellar Hemisphere UHRF1BP1 0.22 0.16 lasso 12 0.15 1.0e-04 -7.0 -7.7 1.3e-14 0.12 0.22 0.52 FALSE
16 GTEx Brain Cerebellum UHRF1BP1 0.14 0.09 enet 23 0.12 1.5e-04 -7.0 -5.8 7.3e-09 0.10 0.18 0.23 FALSE
17 GTEx Brain Frontal Cortex BA9 UHRF1BP1 0.18 0.00 lasso 10 0.02 7.3e-02 -8.2 -5.9 3.5e-09 0.15 0.10 0.23 FALSE
18 GTEx Brain Frontal Cortex BA9 RPS10 0.21 0.08 lasso 3 0.06 8.6e-03 -6.5 -7.8 8.7e-15 0.75 0.06 0.56 FALSE
19 GTEx Brain Putamen basal ganglia UHRF1BP1 0.20 0.17 lasso 2 0.16 1.5e-04 -7.0 -7.1 1.5e-12 0.13 0.22 0.20 FALSE
20 GTEx Breast Mammary Tissue UHRF1BP1 0.34 0.28 enet 46 0.29 4.7e-15 -6.9 -6.1 1.2e-09 0.06 0.98 0.02 FALSE
21 GTEx Breast Mammary Tissue (Male) UHRF1BP1 0.19 0.16 enet 24 0.08 5.6e-03 -7.0 -7.0 2.1e-12 0.13 0.36 0.22 FALSE
22 GTEx Breast Mammary Tissue (Female) UHRF1BP1 0.23 0.21 lasso 3 0.20 1.0e-06 -7.0 -6.0 1.5e-09 0.12 0.73 0.15 FALSE
23 GTEx Cells EBV-transformed lymphocytes C6orf106 0.20 0.00 lasso 5 0.00 2.7e-01 -6.7 -5.7 1.4e-08 0.14 0.07 0.05 FALSE
24 GTEx Cells Transformed fibroblasts UHRF1BP1 0.34 0.32 enet 44 0.31 2.4e-23 -7.0 -7.2 4.4e-13 0.12 1.00 0.00 FALSE
25 GTEx Cells Transformed fibroblasts RPS10 0.12 0.05 lasso 4 0.06 4.5e-05 -8.3 -8.2 3.1e-16 0.93 0.02 0.98 TRUE
26 GTEx Colon Sigmoid UHRF1BP1 0.44 0.36 lasso 12 0.38 1.8e-14 -7.0 -5.3 1.4e-07 0.09 0.99 0.01 FALSE
27 GTEx Colon Transverse UHRF1BP1 0.42 0.28 lasso 4 0.28 1.6e-13 -6.9 -7.2 5.6e-13 0.12 0.84 0.16 FALSE
28 GTEx Esophagus Gastroesophageal Junction UHRF1BP1 0.47 0.38 enet 22 0.43 7.3e-17 -8.1 -7.5 5.4e-14 0.08 0.15 0.85 FALSE
29 GTEx Esophagus Mucosa UHRF1BP1 0.14 0.15 enet 28 0.17 1.3e-11 -7.2 -7.1 1.0e-12 0.12 0.97 0.03 FALSE
30 GTEx Esophagus Mucosa SNRPC 0.12 0.10 lasso 2 0.08 4.8e-06 -7.2 7.2 5.9e-13 -0.11 0.92 0.07 FALSE
31 GTEx Esophagus Muscularis UHRF1BP1 0.42 0.35 enet 48 0.33 1.0e-20 -7.0 -6.6 5.5e-11 0.18 0.99 0.01 FALSE
32 GTEx Esophagus Muscularis SNRPC 0.09 0.11 lasso 3 0.07 3.8e-05 -7.0 7.4 9.5e-14 -0.12 0.40 0.60 FALSE
33 GTEx Esophagus Muscularis NUDT3 0.12 0.00 lasso 7 0.02 3.2e-02 -8.4 7.9 3.1e-15 -0.85 0.02 0.85 FALSE
34 GTEx Heart Atrial Appendage UHRF1BP1 0.13 0.07 enet 17 0.05 1.9e-03 -7.1 -5.3 1.5e-07 0.17 0.51 0.12 TRUE
35 GTEx Heart Left Ventricle UHRF1BP1 0.23 0.12 lasso 7 0.22 1.2e-11 -6.9 -6.5 9.8e-11 0.06 0.67 0.33 FALSE
36 GTEx Liver UHRF1BP1 0.13 0.04 lasso 3 0.05 1.8e-02 -7.0 -6.9 6.2e-12 0.08 0.16 0.12 FALSE
37 GTEx Lung UHRF1BP1 0.17 0.20 enet 22 0.18 4.3e-14 -7.0 -7.1 1.0e-12 0.10 0.99 0.01 FALSE
38 GTEx Muscle Skeletal UHRF1BP1 0.34 0.34 enet 45 0.39 4.3e-40 -7.0 -6.2 7.0e-10 0.07 1.00 0.00 FALSE
39 GTEx Muscle Skeletal SNRPC 0.03 0.02 lasso 3 0.02 8.3e-03 -7.1 7.3 3.5e-13 -0.13 0.29 0.26 FALSE
40 GTEx Muscle Skeletal C6orf106 0.08 0.06 lasso 4 0.06 7.1e-07 -5.7 6.8 8.4e-12 -0.19 0.89 0.09 FALSE
41 GTEx Nerve Tibial UHRF1BP1 0.31 0.31 lasso 6 0.31 3.9e-22 -7.0 -7.0 2.6e-12 0.12 0.99 0.01 FALSE
42 GTEx Nerve Tibial SNRPC 0.12 0.10 lasso 4 0.08 1.5e-06 -7.0 7.1 1.5e-12 -0.11 0.65 0.35 FALSE
43 GTEx Pancreas C6orf106 0.14 0.11 enet 11 0.13 2.8e-06 -5.7 -5.3 9.0e-08 0.13 0.86 0.01 FALSE
44 GTEx Skin Not Sun Exposed Suprapubic UHRF1BP1 0.20 0.10 enet 30 0.15 2.1e-08 -7.0 -5.2 2.5e-07 0.06 0.90 0.10 FALSE
45 GTEx Skin Sun Exposed Lower leg UHRF1BP1 0.19 0.13 enet 33 0.14 2.7e-11 -7.0 -6.2 5.0e-10 -0.03 0.81 0.19 TRUE
46 GTEx Skin Sun Exposed Lower leg SNRPC 0.03 0.04 lasso 2 0.03 1.9e-03 -7.0 7.0 1.9e-12 -0.11 0.44 0.25 FALSE
47 GTEx Small Intestine Terminal Ileum UHRF1BP1 0.20 0.03 lasso 5 0.00 3.4e-01 -7.0 -6.5 1.0e-10 0.09 0.12 0.22 FALSE
48 GTEx Spleen UHRF1BP1 0.34 0.21 enet 36 0.17 4.5e-05 -7.2 -8.4 6.5e-17 0.32 0.39 0.40 TRUE
49 GTEx Stomach UHRF1BP1 0.24 0.22 enet 20 0.23 2.2e-11 -6.5 -6.5 7.1e-11 0.17 0.98 0.02 FALSE
50 GTEx Testis RPS10 0.17 0.11 lasso 1 0.04 5.2e-03 -6.8 -6.8 1.5e-11 0.74 0.10 0.67 FALSE
51 GTEx Thyroid SNRPC 0.07 0.04 lasso 6 0.05 1.6e-04 -7.0 6.9 4.4e-12 -0.11 0.79 0.05 FALSE
52 GTEx Uterus UHRF1BP1 0.20 0.03 lasso 4 0.07 1.8e-02 -7.0 -7.4 1.3e-13 0.17 0.10 0.13 FALSE
53 GTEx Vagina UHRF1BP1 0.31 0.05 lasso 8 0.04 5.0e-02 -7.0 -6.4 1.3e-10 0.07 0.14 0.19 FALSE
54 GTEx Whole Blood UHRF1BP1 0.14 0.14 lasso 7 0.14 2.9e-13 -7.0 -6.4 1.8e-10 0.13 0.99 0.01 FALSE
55 METSIM Adipose C6orf106 0.04 0.02 blup 381 0.02 7.7e-04 -3.8 -5.6 1.8e-08 0.11 0.38 0.13 TRUE
56 METSIM Adipose SNRPC 0.05 0.05 lasso 7 0.07 2.9e-11 -7.1 5.8 6.9e-09 -0.10 0.99 0.01 FALSE
57 METSIM Adipose UHRF1BP1 0.16 0.31 enet 30 0.32 1.0e-49 -7.1 -6.5 5.9e-11 0.11 0.99 0.01 FALSE
58 NTR Blood C6orf106 0.03 0.02 lasso 6 0.02 7.2e-07 -6.2 -5.9 4.0e-09 0.10 0.99 0.00 FALSE
59 NTR Blood UHRF1BP1 0.03 0.05 enet 19 0.05 7.4e-15 -6.7 -6.7 1.9e-11 0.09 0.99 0.01 FALSE
60 ROSMAP Brain Pre-frontal Cortex TEAD3 0.07 0.03 bslmm 421 0.04 5.6e-06 -3.6 5.6 1.7e-08 -0.23 0.10 0.72 FALSE
61 ROSMAP Brain Pre-frontal Cortex UHRF1BP1 0.16 0.27 lasso 10 0.28 2.7e-36 -6.7 -6.8 9.2e-12 0.11 1.00 0.00 FALSE
62 ROSMAP Brain Pre-frontal Cortex PACSIN1 0.09 0.00 blup 359 0.02 4.5e-04 -6.0 -5.2 2.0e-07 0.38 0.18 0.08 FALSE
63 ROSMAP Brain Pre-frontal Cortex SNRPC 0.15 0.27 lasso 4 0.27 4.0e-35 -7.1 7.0 1.9e-12 -0.11 1.00 0.00 FALSE
64 YFS Blood NUDT3 0.12 0.12 lasso 9 0.13 2.5e-40 -6.8 -5.5 3.8e-08 0.61 1.00 0.00 TRUE
65 YFS Blood SNRPC 0.02 0.03 lasso 5 0.02 3.0e-08 -8.1 8.2 3.2e-16 -0.12 0.04 0.96 TRUE
66 YFS Blood UHRF1BP1 0.18 0.34 enet 36 0.34 2.5e-117 -7.1 -7.4 1.2e-13 0.16 1.00 0.00 FALSE
67 The Cancer Genome Atlas Bladder Urothelial Carcinoma UHRF1BP1 0.03 0.04 lasso 3 0.04 1.7e-04 -7.0 -7.0 1.9e-12 0.11 0.08 0.75 FALSE
68 The Cancer Genome Atlas Breast Invasive Carcinoma SNRPC 0.01 0.01 blup 31 0.00 3.0e-02 -4.0 6.2 5.5e-10 -0.12 0.03 0.14 FALSE
69 The Cancer Genome Atlas Breast Invasive Carcinoma UHRF1BP1 0.04 0.05 lasso 3 0.04 8.4e-09 -7.0 -7.0 1.9e-12 0.11 0.65 0.35 FALSE
70 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma UHRF1BP1 0.07 0.11 lasso 3 0.07 2.6e-04 -6.9 -6.9 4.4e-12 0.11 0.22 0.72 FALSE
71 The Cancer Genome Atlas Colon Adenocarcinoma UHRF1BP1 0.08 0.11 lasso 12 0.10 2.3e-06 -7.1 -7.0 1.9e-12 0.11 0.41 0.59 FALSE
72 The Cancer Genome Atlas Esophageal Carcinoma UHRF1BP1 0.19 0.20 lasso 10 0.17 5.2e-06 -6.9 -7.0 3.4e-12 0.11 0.55 0.39 FALSE
73 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SNRPC 0.06 0.07 lasso 2 0.07 6.7e-08 -7.0 7.0 1.9e-12 -0.11 0.69 0.31 FALSE
74 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma UHRF1BP1 0.18 0.28 lasso 5 0.27 1.0e-30 -7.1 -7.1 8.9e-13 0.12 0.94 0.06 FALSE
75 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma UHRF1BP1 0.08 0.09 blup 71 0.10 2.0e-06 -7.1 -5.4 5.1e-08 0.14 0.55 0.43 FALSE
76 The Cancer Genome Atlas Brain Lower Grade Glioma C6orf106 0.04 0.05 lasso 4 0.03 8.1e-05 -6.2 -6.1 9.3e-10 0.13 0.97 0.03 TRUE
77 The Cancer Genome Atlas Liver Hepatocellular Carcinoma UHRF1BP1 0.12 0.09 blup 70 0.06 5.6e-04 -7.0 -7.3 2.1e-13 0.11 0.06 0.78 FALSE
78 The Cancer Genome Atlas Lung Adenocarcinoma UHRF1BP1 0.06 0.07 enet 20 0.08 6.4e-10 -7.0 -6.2 4.7e-10 0.11 0.94 0.06 FALSE
79 The Cancer Genome Atlas Lung Squamous Cell Carcinoma UHRF1BP1 0.04 0.06 blup 70 0.06 1.5e-07 -7.1 -6.4 1.6e-10 0.07 0.12 0.88 FALSE
80 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C6orf106 0.14 0.07 enet 6 0.06 1.0e-04 -6.2 -5.6 1.8e-08 0.08 0.20 0.54 FALSE
81 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma UHRF1BP1 0.06 0.07 lasso 1 0.05 1.5e-04 -6.7 -6.7 1.7e-11 0.10 0.21 0.75 FALSE
82 The Cancer Genome Atlas Pancreatic Adenocarcinoma UHRF1BP1 0.20 0.23 lasso 16 0.25 8.3e-11 -7.1 -6.5 7.9e-11 0.12 0.90 0.10 FALSE
83 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma UHRF1BP1 0.13 0.09 enet 13 0.10 6.4e-05 -7.0 -5.6 2.5e-08 0.15 0.21 0.56 FALSE
84 The Cancer Genome Atlas Prostate Adenocarcinoma UHRF1BP1 0.10 0.20 lasso 5 0.19 1.6e-19 -7.0 -6.9 6.8e-12 0.11 0.94 0.06 FALSE
85 The Cancer Genome Atlas Soft Tissue Sarcoma UHRF1BP1 0.08 0.09 blup 71 0.08 1.0e-05 -7.1 -5.6 1.8e-08 0.11 0.60 0.25 FALSE
86 The Cancer Genome Atlas Stomach Adenocarcinoma UHRF1BP1 0.08 0.10 lasso 1 0.10 7.1e-08 -7.1 -7.1 1.6e-12 0.11 0.81 0.19 FALSE
87 The Cancer Genome Atlas Thyroid Carcinoma SNRPC 0.05 0.05 blup 31 0.05 2.9e-05 -7.0 6.3 4.0e-10 -0.13 0.70 0.21 FALSE
88 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma SNRPC 0.09 0.11 lasso 2 0.10 8.1e-04 -7.0 7.0 2.2e-12 -0.11 0.03 0.58 FALSE