[Hub]/) : Traits : Impedance of leg (left) : ← →

chr6:33,551,514-36,158,878

Best TWAS P=6.45e-17 · Best GWAS P=3.49e-17 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
48	GTEx	Spleen	UHRF1BP1	0.34	0.21	enet	36	0.17	4.5e-05	-7.2	-8.4	6.5e-17	0.32	0.39	0.40	TRUE
25	GTEx	Cells Transformed fibroblasts	RPS10	0.12	0.05	lasso	4	0.06	4.5e-05	-8.3	-8.2	3.1e-16	0.93	0.02	0.98	TRUE
65	YFS	Blood	SNRPC	0.02	0.03	lasso	5	0.02	3.0e-08	-8.1	8.2	3.2e-16	-0.12	0.04	0.96	TRUE
45	GTEx	Skin Sun Exposed Lower leg	UHRF1BP1	0.19	0.13	enet	33	0.14	2.7e-11	-7.0	-6.2	5.0e-10	-0.03	0.81	0.19	TRUE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	C6orf106	0.04	0.05	lasso	4	0.03	8.1e-05	-6.2	-6.1	9.3e-10	0.13	0.97	0.03	TRUE
55	METSIM	Adipose	C6orf106	0.04	0.02	blup	381	0.02	7.7e-04	-3.8	-5.6	1.8e-08	0.11	0.38	0.13	TRUE
64	YFS	Blood	NUDT3	0.12	0.12	lasso	9	0.13	2.5e-40	-6.8	-5.5	3.8e-08	0.61	1.00	0.00	TRUE
34	GTEx	Heart Atrial Appendage	UHRF1BP1	0.13	0.07	enet	17	0.05	1.9e-03	-7.1	-5.3	1.5e-07	0.17	0.51	0.12	TRUE
33	GTEx	Esophagus Muscularis	NUDT3	0.12	0.00	lasso	7	0.02	3.2e-02	-8.4	7.9	3.1e-15	-0.85	0.02	0.85	FALSE
18	GTEx	Brain Frontal Cortex BA9	RPS10	0.21	0.08	lasso	3	0.06	8.6e-03	-6.5	-7.8	8.7e-15	0.75	0.06	0.56	FALSE
15	GTEx	Brain Cerebellar Hemisphere	UHRF1BP1	0.22	0.16	lasso	12	0.15	1.0e-04	-7.0	-7.7	1.3e-14	0.12	0.22	0.52	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PACSIN1	0.07	0.01	lasso	6	0.02	1.1e-03	-6.2	-7.6	2.6e-14	0.37	0.32	0.04	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	UHRF1BP1	0.47	0.38	enet	22	0.43	7.3e-17	-8.1	-7.5	5.4e-14	0.08	0.15	0.85	FALSE
12	GTEx	Artery Tibial	SNRPC	0.06	0.06	lasso	4	0.05	1.3e-04	-7.1	7.5	7.8e-14	-0.12	0.30	0.69	FALSE
32	GTEx	Esophagus Muscularis	SNRPC	0.09	0.11	lasso	3	0.07	3.8e-05	-7.0	7.4	9.5e-14	-0.12	0.40	0.60	FALSE
66	YFS	Blood	UHRF1BP1	0.18	0.34	enet	36	0.34	2.5e-117	-7.1	-7.4	1.2e-13	0.16	1.00	0.00	FALSE
8	GTEx	Artery Aorta	UHRF1BP1	0.35	0.32	lasso	10	0.30	7.7e-17	-7.1	-7.4	1.3e-13	0.15	0.98	0.02	FALSE
52	GTEx	Uterus	UHRF1BP1	0.20	0.03	lasso	4	0.07	1.8e-02	-7.0	-7.4	1.3e-13	0.17	0.10	0.13	FALSE
77	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	UHRF1BP1	0.12	0.09	blup	70	0.06	5.6e-04	-7.0	-7.3	2.1e-13	0.11	0.06	0.78	FALSE
14	GTEx	Brain Caudate basal ganglia	SNRPC	0.19	0.15	lasso	3	0.06	7.7e-03	-7.0	7.3	3.4e-13	-0.11	0.42	0.08	FALSE
39	GTEx	Muscle Skeletal	SNRPC	0.03	0.02	lasso	3	0.02	8.3e-03	-7.1	7.3	3.5e-13	-0.13	0.29	0.26	FALSE
24	GTEx	Cells Transformed fibroblasts	UHRF1BP1	0.34	0.32	enet	44	0.31	2.4e-23	-7.0	-7.2	4.4e-13	0.12	1.00	0.00	FALSE
27	GTEx	Colon Transverse	UHRF1BP1	0.42	0.28	lasso	4	0.28	1.6e-13	-6.9	-7.2	5.6e-13	0.12	0.84	0.16	FALSE
30	GTEx	Esophagus Mucosa	SNRPC	0.12	0.10	lasso	2	0.08	4.8e-06	-7.2	7.2	5.9e-13	-0.11	0.92	0.07	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SNRPC	0.10	0.16	lasso	4	0.15	3.6e-18	-7.2	7.1	8.8e-13	-0.12	0.99	0.01	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UHRF1BP1	0.18	0.28	lasso	5	0.27	1.0e-30	-7.1	-7.1	8.9e-13	0.12	0.94	0.06	FALSE
29	GTEx	Esophagus Mucosa	UHRF1BP1	0.14	0.15	enet	28	0.17	1.3e-11	-7.2	-7.1	1.0e-12	0.12	0.97	0.03	FALSE
37	GTEx	Lung	UHRF1BP1	0.17	0.20	enet	22	0.18	4.3e-14	-7.0	-7.1	1.0e-12	0.10	0.99	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	UHRF1BP1	0.17	0.23	lasso	19	0.22	5.8e-27	-7.0	-7.1	1.2e-12	0.11	0.99	0.01	FALSE
4	GTEx	Adipose Subcutaneous	UHRF1BP1	0.30	0.35	enet	28	0.36	1.6e-30	-7.0	-7.1	1.5e-12	0.11	1.00	0.00	FALSE
19	GTEx	Brain Putamen basal ganglia	UHRF1BP1	0.20	0.17	lasso	2	0.16	1.5e-04	-7.0	-7.1	1.5e-12	0.13	0.22	0.20	FALSE
42	GTEx	Nerve Tibial	SNRPC	0.12	0.10	lasso	4	0.08	1.5e-06	-7.0	7.1	1.5e-12	-0.11	0.65	0.35	FALSE
86	The Cancer Genome Atlas	Stomach Adenocarcinoma	UHRF1BP1	0.08	0.10	lasso	1	0.10	7.1e-08	-7.1	-7.1	1.6e-12	0.11	0.81	0.19	FALSE
46	GTEx	Skin Sun Exposed Lower leg	SNRPC	0.03	0.04	lasso	2	0.03	1.9e-03	-7.0	7.0	1.9e-12	-0.11	0.44	0.25	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	SNRPC	0.15	0.27	lasso	4	0.27	4.0e-35	-7.1	7.0	1.9e-12	-0.11	1.00	0.00	FALSE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UHRF1BP1	0.03	0.04	lasso	3	0.04	1.7e-04	-7.0	-7.0	1.9e-12	0.11	0.08	0.75	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	UHRF1BP1	0.04	0.05	lasso	3	0.04	8.4e-09	-7.0	-7.0	1.9e-12	0.11	0.65	0.35	FALSE
71	The Cancer Genome Atlas	Colon Adenocarcinoma	UHRF1BP1	0.08	0.11	lasso	12	0.10	2.3e-06	-7.1	-7.0	1.9e-12	0.11	0.41	0.59	FALSE
73	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SNRPC	0.06	0.07	lasso	2	0.07	6.7e-08	-7.0	7.0	1.9e-12	-0.11	0.69	0.31	FALSE
21	GTEx	Breast Mammary Tissue (Male)	UHRF1BP1	0.19	0.16	enet	24	0.08	5.6e-03	-7.0	-7.0	2.1e-12	0.13	0.36	0.22	FALSE
10	GTEx	Artery Coronary	UHRF1BP1	0.33	0.36	lasso	2	0.35	1.6e-12	-7.0	-7.0	2.2e-12	0.11	0.95	0.05	FALSE
88	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SNRPC	0.09	0.11	lasso	2	0.10	8.1e-04	-7.0	7.0	2.2e-12	-0.11	0.03	0.58	FALSE
6	GTEx	Adipose Visceral Omentum	UHRF1BP1	0.30	0.34	lasso	3	0.34	3.0e-18	-6.9	-7.0	2.6e-12	0.11	0.99	0.01	FALSE
41	GTEx	Nerve Tibial	UHRF1BP1	0.31	0.31	lasso	6	0.31	3.9e-22	-7.0	-7.0	2.6e-12	0.12	0.99	0.01	FALSE
72	The Cancer Genome Atlas	Esophageal Carcinoma	UHRF1BP1	0.19	0.20	lasso	10	0.17	5.2e-06	-6.9	-7.0	3.4e-12	0.11	0.55	0.39	FALSE
51	GTEx	Thyroid	SNRPC	0.07	0.04	lasso	6	0.05	1.6e-04	-7.0	6.9	4.4e-12	-0.11	0.79	0.05	FALSE
70	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	UHRF1BP1	0.07	0.11	lasso	3	0.07	2.6e-04	-6.9	-6.9	4.4e-12	0.11	0.22	0.72	FALSE
36	GTEx	Liver	UHRF1BP1	0.13	0.04	lasso	3	0.05	1.8e-02	-7.0	-6.9	6.2e-12	0.08	0.16	0.12	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	UHRF1BP1	0.10	0.20	lasso	5	0.19	1.6e-19	-7.0	-6.9	6.8e-12	0.11	0.94	0.06	FALSE
40	GTEx	Muscle Skeletal	C6orf106	0.08	0.06	lasso	4	0.06	7.1e-07	-5.7	6.8	8.4e-12	-0.19	0.89	0.09	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	UHRF1BP1	0.16	0.27	lasso	10	0.28	2.7e-36	-6.7	-6.8	9.2e-12	0.11	1.00	0.00	FALSE
11	GTEx	Artery Tibial	UHRF1BP1	0.31	0.43	lasso	11	0.43	4.0e-36	-7.0	-6.8	1.4e-11	0.10	1.00	0.00	FALSE
50	GTEx	Testis	RPS10	0.17	0.11	lasso	1	0.04	5.2e-03	-6.8	-6.8	1.5e-11	0.74	0.10	0.67	FALSE
81	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	UHRF1BP1	0.06	0.07	lasso	1	0.05	1.5e-04	-6.7	-6.7	1.7e-11	0.10	0.21	0.75	FALSE
59	NTR	Blood	UHRF1BP1	0.03	0.05	enet	19	0.05	7.4e-15	-6.7	-6.7	1.9e-11	0.09	0.99	0.01	FALSE
31	GTEx	Esophagus Muscularis	UHRF1BP1	0.42	0.35	enet	48	0.33	1.0e-20	-7.0	-6.6	5.5e-11	0.18	0.99	0.01	FALSE
57	METSIM	Adipose	UHRF1BP1	0.16	0.31	enet	30	0.32	1.0e-49	-7.1	-6.5	5.9e-11	0.11	0.99	0.01	FALSE
49	GTEx	Stomach	UHRF1BP1	0.24	0.22	enet	20	0.23	2.2e-11	-6.5	-6.5	7.1e-11	0.17	0.98	0.02	FALSE
82	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UHRF1BP1	0.20	0.23	lasso	16	0.25	8.3e-11	-7.1	-6.5	7.9e-11	0.12	0.90	0.10	FALSE
13	GTEx	Brain Caudate basal ganglia	UHRF1BP1	0.19	0.14	lasso	7	0.12	3.1e-04	-7.0	-6.5	8.8e-11	0.11	0.40	0.07	FALSE
35	GTEx	Heart Left Ventricle	UHRF1BP1	0.23	0.12	lasso	7	0.22	1.2e-11	-6.9	-6.5	9.8e-11	0.06	0.67	0.33	FALSE
47	GTEx	Small Intestine Terminal Ileum	UHRF1BP1	0.20	0.03	lasso	5	0.00	3.4e-01	-7.0	-6.5	1.0e-10	0.09	0.12	0.22	FALSE
53	GTEx	Vagina	UHRF1BP1	0.31	0.05	lasso	8	0.04	5.0e-02	-7.0	-6.4	1.3e-10	0.07	0.14	0.19	FALSE
79	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UHRF1BP1	0.04	0.06	blup	70	0.06	1.5e-07	-7.1	-6.4	1.6e-10	0.07	0.12	0.88	FALSE
54	GTEx	Whole Blood	UHRF1BP1	0.14	0.14	lasso	7	0.14	2.9e-13	-7.0	-6.4	1.8e-10	0.13	0.99	0.01	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	SNRPC	0.05	0.05	blup	31	0.05	2.9e-05	-7.0	6.3	4.0e-10	-0.13	0.70	0.21	FALSE
78	The Cancer Genome Atlas	Lung Adenocarcinoma	UHRF1BP1	0.06	0.07	enet	20	0.08	6.4e-10	-7.0	-6.2	4.7e-10	0.11	0.94	0.06	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNRPC	0.01	0.01	blup	31	0.00	3.0e-02	-4.0	6.2	5.5e-10	-0.12	0.03	0.14	FALSE
38	GTEx	Muscle Skeletal	UHRF1BP1	0.34	0.34	enet	45	0.39	4.3e-40	-7.0	-6.2	7.0e-10	0.07	1.00	0.00	FALSE
7	GTEx	Adrenal Gland	UHRF1BP1	0.32	0.26	enet	33	0.33	1.3e-12	-7.0	-6.1	8.8e-10	0.02	0.51	0.49	FALSE
5	GTEx	Adipose Subcutaneous	SNRPC	0.13	0.13	enet	21	0.13	1.2e-10	-7.0	6.1	1.1e-09	-0.03	0.99	0.01	FALSE
20	GTEx	Breast Mammary Tissue	UHRF1BP1	0.34	0.28	enet	46	0.29	4.7e-15	-6.9	-6.1	1.2e-09	0.06	0.98	0.02	FALSE
22	GTEx	Breast Mammary Tissue (Female)	UHRF1BP1	0.23	0.21	lasso	3	0.20	1.0e-06	-7.0	-6.0	1.5e-09	0.12	0.73	0.15	FALSE
17	GTEx	Brain Frontal Cortex BA9	UHRF1BP1	0.18	0.00	lasso	10	0.02	7.3e-02	-8.2	-5.9	3.5e-09	0.15	0.10	0.23	FALSE
58	NTR	Blood	C6orf106	0.03	0.02	lasso	6	0.02	7.2e-07	-6.2	-5.9	4.0e-09	0.10	0.99	0.00	FALSE
9	GTEx	Artery Aorta	SNRPC	0.06	0.03	enet	14	0.02	1.8e-02	-8.2	5.8	5.0e-09	-0.10	0.13	0.50	FALSE
56	METSIM	Adipose	SNRPC	0.05	0.05	lasso	7	0.07	2.9e-11	-7.1	5.8	6.9e-09	-0.10	0.99	0.01	FALSE
16	GTEx	Brain Cerebellum	UHRF1BP1	0.14	0.09	enet	23	0.12	1.5e-04	-7.0	-5.8	7.3e-09	0.10	0.18	0.23	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	C6orf106	0.20	0.00	lasso	5	0.00	2.7e-01	-6.7	-5.7	1.4e-08	0.14	0.07	0.05	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	TEAD3	0.07	0.03	bslmm	421	0.04	5.6e-06	-3.6	5.6	1.7e-08	-0.23	0.10	0.72	FALSE
80	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C6orf106	0.14	0.07	enet	6	0.06	1.0e-04	-6.2	-5.6	1.8e-08	0.08	0.20	0.54	FALSE
85	The Cancer Genome Atlas	Soft Tissue Sarcoma	UHRF1BP1	0.08	0.09	blup	71	0.08	1.0e-05	-7.1	-5.6	1.8e-08	0.11	0.60	0.25	FALSE
83	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UHRF1BP1	0.13	0.09	enet	13	0.10	6.4e-05	-7.0	-5.6	2.5e-08	0.15	0.21	0.56	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UHRF1BP1	0.08	0.09	blup	71	0.10	2.0e-06	-7.1	-5.4	5.1e-08	0.14	0.55	0.43	FALSE
43	GTEx	Pancreas	C6orf106	0.14	0.11	enet	11	0.13	2.8e-06	-5.7	-5.3	9.0e-08	0.13	0.86	0.01	FALSE
26	GTEx	Colon Sigmoid	UHRF1BP1	0.44	0.36	lasso	12	0.38	1.8e-14	-7.0	-5.3	1.4e-07	0.09	0.99	0.01	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	PACSIN1	0.09	0.00	blup	359	0.02	4.5e-04	-6.0	-5.2	2.0e-07	0.38	0.18	0.08	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	UHRF1BP1	0.20	0.10	enet	30	0.15	2.1e-08	-7.0	-5.2	2.5e-07	0.06	0.90	0.10	FALSE