TWAS hub - POM121

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1100	0.0490	6.2e-05	0.025	NA	0.053	NA	0.063	1.1e-02	NA	0.00039	NA	0.00011
2	GTEx	Thyroid	0.0570	0.0310	2.5e-03	0.014	NA	0.029	NA	0.024	2.6e-02	NA	0.00250	NA	0.00580
3	METSIM	Adipose	0.0501	0.0248	6.4e-05	0.031	0.035	0.020	0.034	0.030	1.6e-05	5.4e-06	0.00043	5.6e-06	0.00002

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Triglycerides	14.3	23.5	36.0	-4.3	-4.0	-6.0
Gout (self-reported)	7.7	10.6	14.7	-2.9	-2.9	-3.8
Falls in the last year	7.4	10.0	13.4	-3.7	-2.0	-3.6
Impedance of arm (right)	6.9	32.1	37.7	-4.6	-6.1	-6.1
Impedance of whole body	6.7	34.3	42.3	-5.0	-6.0	-6.5
Impedance of arm (left)	6.6	30.4	38.0	-4.6	-5.7	-6.2
Chest pain or discomfort	6.5	9.3	11.2	-3.3	-2.5	-3.2
Impedance of leg (right)	6.2	29.9	35.9	-4.8	-5.5	-6.0
Father’s age at death	5.9	7.9	10.2	2.1	3.2	3.0
Medication: Allopurinol	5.8	7.7	10.1	-2.8	-2.2	-3.2
Ever smoked	5.8	10.2	11.5	-3.4	-2.9	-3.3
Fluid intelligence score	5.7	11.8	14.6	3.8	3.3	3.1
Impedance of leg (left)	5.5	26.6	32.7	-4.6	-5.1	-5.7
Leg pain on walking	4.9	6.1	9.2	-1.9	-3.0	-2.3
Lupus	4.3	6.6	7.6	-2.7	-2.8	-2.2
Intelligence (Savage-Jansen 2018)	4.0	12.4	16.4	4.0	3.0	3.4
Verbal and Numeric Reasoning (VNR)	4.0	9.7	11.6	3.4	2.6	3.3
Mouth/teeth dental problems	3.5	5.4	6.5	2.5	2.5	1.8
Past tobacco smoking	3.3	6.1	7.9	2.6	1.9	2.8
Medication: Blood pressure	3.2	5.6	8.8	-3.0	-1.5	-2.4
Medication: Co-codamol	3.1	3.6	4.5	-2.1	-1.9	-1.6
Severe depression (siblings)	3.1	3.5	6.9	2.6	0.5	1.8
Hair/balding pattern: Pattern 3	2.9	4.3	8.0	-1.1	-2.8	-1.9
Mother’s age at death	2.9	3.7	5.9	1.6	2.4	1.5
Noisy workplace	2.8	3.5	7.3	-2.7	-1.4	-1.1
Commuting to job workplace: Public transport	2.8	3.4	4.4	1.8	1.6	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.2	6.0	-1.3	-2.4	-2.2
Type 2 Diabetes (T2D) (2012)	2.6	3.0	4.0	1.7	1.5	2.0
Alcohol intake versus 10 years previously	2.6	3.8	4.3	-2.1	-1.7	-2.1
Medication: Amlodipine	2.6	3.7	6.4	-2.1	-0.3	-2.5
Sensitivity / hurt feelings	2.5	4.3	7.1	-1.1	-2.7	-2.1
Number of treatments/medications taken	2.4	4.3	4.6	-2.1	-2.0	-2.0
Had major operations	2.4	2.8	4.5	-2.1	-1.2	-1.6
Cardiovascular Disease	2.3	7.8	8.3	-2.8	-2.7	-2.9
Supplements: Vitamin C	2.3	2.8	4.1	-1.5	-1.4	-2.0
Smoking Status	2.2	5.4	6.7	-2.6	-1.9	-2.5
High blood pressure (mother)	2.2	3.0	4.7	-1.5	-2.2	-1.4
Serious illness, injury or assault to yourself	2.1	2.6	3.6	-1.9	-1.6	-1.3
Qualifications: College or University degree	2.1	6.5	11.5	3.4	1.5	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	5.2	1.9	2.2	2.3
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	4.8	-1.8	-2.2	-1.1
Qualifications: None of the above	2.0	4.4	8.6	-2.9	-0.7	-2.0
Prospective memory result	2.0	2.4	3.8	-1.9	-1.3	-1.4
Age at last live birth	2.0	2.9	3.3	1.8	1.5	1.8
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.5	4.6	-1.4	-0.8	-2.1
Ever depressed for a whole week	2.0	2.5	3.1	1.8	1.4	1.6
Breast Cancer	1.9	4.6	7.2	-1.8	-2.7	-1.8
Blood White Count	1.9	14.1	20.2	-3.1	-3.5	-4.5
Systolic Blood Pressure	1.9	9.3	9.7	-3.1	-3.1	-3.0
HDL Cholesterol	1.8	3.0	3.6	1.5	1.9	1.8
Mood swings	1.8	3.3	6.5	-1.2	-2.5	-1.4
Age started oral contraceptive pill	1.8	2.3	2.7	1.4	1.6	1.5
Unable to work because of sickness or disability	1.8	2.4	3.1	-1.8	-1.6	-1.1
Age at First Birth	1.7	2.5	3.9	2.0	1.3	1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	6.0	1.9	1.5	2.5
Standing height	1.7	16.8	24.8	-3.1	-5.0	-4.0
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	2.3	1.5	1.1	1.4
Ever taken oral contraceptive pill	1.7	1.9	3.1	1.3	1.0	1.8
Irritability	1.7	2.8	5.1	-0.7	-2.3	-1.7
Ever had prostate specific antigen (PSA) test	1.7	1.9	3.0	1.1	1.7	1.2
Heel T-Score	1.6	12.3	15.4	2.8	3.9	3.7
Medication: Atenolol	1.6	2.0	2.9	-0.8	-1.5	-1.7
Illnesses of mother	1.6	2.0	4.7	1.1	2.2	0.4
Crohns Disease (2012)	1.5	2.4	4.0	-2.0	-1.3	-1.2
Supplements: Zinc	1.5	1.6	3.5	-1.9	-0.6	-1.0
Pain all over the body in last month	1.5	1.7	3.8	-0.7	-2.0	-0.8
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.2	2.1	0.5	1.6
Wears glasses or contact lenses	1.5	1.7	2.8	1.2	1.0	1.7
Neuroticism (2016)	1.4	2.0	3.2	-1.4	-0.8	-1.8
Townsend deprivation index at recruitment	1.4	2.0	3.0	-1.7	-0.8	-1.5
Body mass index (BMI)	1.4	5.9	10.8	1.3	3.3	2.3
Age at first live birth	1.4	2.5	3.1	1.6	1.8	1.4
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.3	1.3	0.9	1.5
LDL Cholesterol	1.3	2.0	3.9	1.2	0.9	2.0
Qualifications: CSEs or equivalent	1.3	1.8	2.8	-1.2	-1.7	-1.0
Neuroticism score	1.3	2.6	6.7	-0.4	-2.6	-1.0
Medication: Lansoprazole	1.3	1.4	2.4	-1.5	-0.9	-1.0
Hypertension (Self-reported)	1.3	3.7	6.3	-2.5	-1.1	-1.8
Smoking status: Previous	1.3	2.0	3.7	-1.4	-0.6	-1.9
Risk taking	1.3	1.9	3.6	1.9	-0.4	1.4
Fractured/broken bones in last 5 years	1.3	1.7	2.7	-1.1	-1.1	-1.6
Waist Hip Ratio (WHR)	1.2	5.4	8.0	-1.1	-2.8	-2.7
Diabetes (father)	1.2	1.4	2.3	1.5	0.3	1.4
Fed-up feelings	1.2	2.2	6.2	-0.1	-2.5	-0.6
Worrier / anxious feelings	1.2	2.3	5.3	-0.9	-2.3	-1.0
Qualifications: A levels/AS levels or equivalent	1.2	2.6	5.2	2.3	0.5	1.5
Mouth/teeth dental problems: Dentures	1.2	2.0	3.8	-2.0	-0.8	-1.2
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.4	1.6	0.4	1.3
Medication: Paracetamol	1.2	2.1	3.5	-1.9	-1.1	-1.2
Alcohol intake frequency.	1.2	2.8	5.5	-1.6	-0.6	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	4.4	-1.0	-2.1	-1.4
Osteoporosis (self-reported)	1.2	1.5	2.4	-1.4	-0.5	-1.5
Height	1.1	21.9	30.8	-3.8	-5.5	-4.5
Lung FEV1/FVC ratio	1.1	5.3	9.1	1.6	3.0	2.1
Tense / ‘highly strung’	1.1	1.8	4.3	0.1	-2.1	-1.0
Hair/balding pattern: Pattern 4	1.1	2.6	3.4	1.4	1.6	1.8
Glaucoma (self-reported)	1.1	1.3	2.3	-0.8	-1.0	-1.5
Comparative body size at age 10	1.1	3.0	5.4	1.4	2.3	1.2
Pain type(s) experienced in last month: Hip pain	1.1	1.4	1.7	-1.2	-1.3	-1.0
Average weekly beer plus cider intake	1.1	1.6	3.4	-0.4	-1.8	-1.1
Blood Platelet Count	1.0	11.0	17.1	-2.5	-3.1	-4.1
BMI	1.0	5.7	11.6	1.3	3.4	1.9
Average weekly spirits intake	1.0	1.3	2.7	-0.5	-1.6	-0.9
Vitamin and mineral supplements	1.0	1.4	2.2	1.0	1.0	1.5
Trunk fat percentage	1.0	3.9	6.2	-2.2	-0.9	-2.5
Average weekly fortified wine intake	1.0	1.1	1.6	-0.7	-1.3	-1.1
High blood pressure	1.0	2.9	5.6	-2.4	-1.0	-1.5
Happiness	1.0	1.2	2.2	1.5	0.4	1.1
Number of full sisters	1.0	1.2	1.5	-1.1	-0.8	-1.2
Medication for cholesterol	1.0	1.6	3.2	0.4	1.1	1.8
Medication: Gliclazide	1.0	1.2	2.1	1.4	0.5	1.1
Alzheimer’s Disease (in mother)	0.9	1.0	2.3	-0.8	-1.5	-0.4
Hearing difficulty/problems with background noise	0.9	1.4	3.5	-0.4	-1.9	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.2	3.0	1.3	1.4	1.7
Diabetes (self-reported)	0.9	1.4	1.9	1.4	1.1	1.0
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.9	-0.1	-1.7	-0.8
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.0	-0.3	-1.1	-1.4
Number of children fathered	0.9	1.1	1.4	-0.8	-1.1	-1.2
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.6	-1.3	-0.4	-1.2
Comparative height size at age 10	0.9	5.1	6.8	-2.0	-2.6	-2.1
Medication: Paracetamol	0.9	1.4	2.5	-1.6	-1.0	-0.8
Myopia	0.9	1.4	2.7	-1.2	-0.1	-1.6
Alcohol drinker status: Previous	0.9	1.0	1.4	-0.9	-0.9	-1.2
Bipolar Disorder (2018)	0.8	1.2	1.9	1.4	0.1	1.4
Birth weight	0.8	1.8	4.1	-2.0	-0.2	-1.1
Diabetes diagnosed by doctor	0.8	1.3	2.0	1.4	0.9	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.5	1.1	0.3	1.2
Guilty feelings	0.8	1.2	1.2	-1.1	-1.0	-1.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.6	1.6	-0.2	0.4
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.5	2.1	0.5	1.3
Body Mass Index (BMI) (2010)	0.7	1.0	1.9	0.9	0.5	1.4
Lung FVC	0.7	3.6	5.4	1.5	1.8	2.3
Hand grip strength (right)	0.7	1.9	3.5	0.5	1.9	1.4
Stomach or abdominal pain in last month	0.7	0.9	1.5	-1.0	-1.2	-0.5
Had menopause	0.7	0.8	1.3	-1.1	0.9	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.8	-0.8	-0.4	-1.4
Mean time to correctly identify matches	0.7	1.3	3.3	0.8	-0.3	1.8
Suffer from ‘nerves’	0.7	1.0	1.8	-0.9	-1.3	-0.6
Ever had bowel cancer screening	0.7	0.9	1.4	-1.2	-0.0	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.4	-1.1	-0.9	-1.2
Medication: Blood pressure	0.7	1.4	1.8	-1.2	-1.4	-1.0
High cholesterol (Self-reported)	0.7	1.2	2.4	-0.4	-1.0	-1.6
Medication: Lisinopril	0.7	0.9	2.0	-0.9	-0.1	-1.4
Illnesses of father: High blood pressure	0.7	0.8	1.9	-1.4	-0.6	-0.6
Number of operations (self-reported)	0.7	1.0	1.3	-0.8	-1.0	-1.2
Neuroticism (Nagel 2018)	0.6	1.5	3.7	-0.1	-1.9	-0.9
Reaction Time	0.6	1.2	2.9	0.6	-0.6	1.7
Bipolar Disorder (2011)	0.6	0.6	0.6	-0.8	-0.8	-0.8
Allergy or Eczema	0.6	1.5	3.9	-0.1	-2.0	0.7
Hypothyroidism (self reported)	0.6	1.3	2.5	-0.6	-1.6	-1.1
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.5	-0.9	-1.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.5	0.6	0.4	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.3	-1.5	-0.0	-0.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.0	-1.0	-0.8	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	2.8	1.5	0.9	1.7
Exposure to tobacco smoke at home	0.6	0.6	1.1	-1.0	-0.5	-0.8
Birth weight of first child	0.6	1.1	2.3	0.7	1.5	0.7
Headache pain in last month	0.6	1.1	2.1	-1.4	-0.3	-1.0
Exposure to tobacco smoke outside home	0.6	0.8	2.1	-0.3	-1.4	-0.5
Number of full brothers	0.6	0.8	1.1	-0.7	-0.9	-1.1
Medication: Seretide 50 evohaler	0.6	0.7	1.1	-0.8	0.5	1.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	-0.8	-0.0	-1.2
Alcohol drinker status: Never	0.6	0.8	1.5	-0.6	-1.2	-0.7
Diastolic blood pressure, automated reading	0.6	1.8	2.7	-1.6	-0.9	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.0	-0.8	-0.6	-1.0
Schizophrenia vs Biploar Disorder	0.5	0.7	1.0	-0.6	-1.0	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.8	2.3	-0.2	-1.5	-0.2
Prostate Cancer	0.5	0.7	1.1	-1.1	-0.8	-0.4
Mean Putamen Volume	0.5	0.6	1.0	-0.6	-1.0	-0.6
HbA1C	0.5	0.5	1.1	0.6	-0.3	1.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.6	0.8	0.6	1.3
Neuroticism	0.5	1.2	2.3	-0.1	-1.5	-1.1
Pack years adult smoking proportion	0.5	0.8	1.8	1.3	-0.2	0.7
Medication: Levothyroxine sodium	0.5	0.8	1.6	-0.4	-1.3	-0.8
Number of incorrect matches in round	0.5	0.8	1.9	-0.7	1.4	0.2
Nervous feelings	0.5	0.9	2.8	0.1	-1.7	0.1
Medication: Cholesterol lowering	0.5	0.8	2.2	0.2	1.5	0.5
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.2	-0.8	-1.0	-1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.6	0.6	-0.2	1.3
High blood pressure (siblings)	0.5	0.7	1.6	-0.5	-1.3	-0.4
Forced vital capacity (FVC), Best measure	0.5	1.7	2.8	1.5	0.2	1.7
Wheeze or whistling in the chest in last year	0.5	0.8	1.5	0.1	1.0	1.2
Medication for pain relief, constipation, heartburn	0.5	0.8	1.3	1.0	0.5	1.1
Illnesses of father: Heart disease	0.5	0.8	0.9	1.0	0.8	0.9
Osteoarthritis (self-reported)	0.5	0.6	1.0	1.0	0.6	0.8
Smoking status: Current	0.5	0.8	1.6	-0.9	-1.2	-0.3
Average weekly champagne plus white wine intake	0.5	0.6	1.7	0.5	0.1	1.3
Medication: Bendroflumethiazide	0.5	0.8	1.6	-1.3	-0.6	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.7	-0.5	1.3	0.3
Depressed Affect (Nagel 2018)	0.4	0.9	2.5	0.5	-1.6	-0.2
Schizophrenia (2018)	0.4	0.9	2.6	-0.1	-1.6	-0.1
Worry (Nagel 2018)	0.4	0.8	2.1	0.3	-1.4	-0.3
Crohns Disease (2017)	0.4	0.9	1.8	-1.3	0.3	-0.9
Ulcerative Colitis	0.4	0.6	1.1	0.7	0.6	1.1
Taking other prescription medications	0.4	0.7	1.4	-0.5	-0.7	-1.2
Trunk fat mass	0.4	1.9	2.8	-1.6	-0.6	-1.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.2	1.1	-0.2	-0.2
Medication: Ramipril	0.4	0.6	1.0	-1.0	0.9	0.1
Illnesses of siblings	0.4	0.5	1.4	0.5	1.2	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.1	-1.0	-1.0	0.0
Asthma	0.4	0.8	1.2	0.8	0.7	1.1
Length of working week for main job	0.4	0.4	0.6	-0.8	-0.5	-0.6
Pulse wave reflection index	0.4	0.5	1.0	0.3	1.0	0.6
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	-0.3	-1.2	0.1
Blood clot in the leg (DVT)	0.4	0.5	1.2	-0.6	1.1	0.1
Arm fat-free mass (right)	0.4	2.0	3.3	0.8	1.5	1.8
Pulse wave peak to peak time	0.4	0.5	1.0	-0.6	-1.0	-0.0
Health satisfaction	0.4	0.5	0.8	0.9	-0.2	0.9
Neck or shoulder pain in last month	0.4	0.6	1.1	-0.1	1.1	0.9
Arm predicted mass (right)	0.4	2.2	3.3	1.0	1.5	1.8
Overall health rating	0.4	0.8	1.5	-0.8	-1.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.7	-0.8	0.8	0.0
Leg fat-free mass (right)	0.4	2.2	2.9	1.3	1.4	1.7
Friendships satisfaction	0.4	0.5	1.2	0.1	-1.1	0.6
Asthma (self-reported)	0.4	0.7	1.3	0.7	0.6	1.1
Leg predicted mass (right)	0.4	2.3	3.0	1.4	1.4	1.7
Number of self-reported non-cancer illnesses	0.4	0.6	1.6	-0.3	-0.4	-1.2
Arm fat-free mass (left)	0.4	1.8	2.5	0.9	1.5	1.6
Heart disease (siblings)	0.4	0.6	0.7	0.8	0.8	0.6
Arm predicted mass (left)	0.4	1.9	2.8	0.9	1.4	1.7
Bipolar Disorder or Schizophrenia	0.3	0.8	1.4	0.8	-1.2	0.7
Ulcerative Colitis (UC)	0.3	0.6	1.5	0.4	1.2	0.4
Major Depression (MDD)	0.3	0.3	1.0	0.1	1.0	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.0	0.5	-1.0	-0.1
Schizophrenia (2014)	0.3	0.7	2.0	-0.1	-1.4	-0.2
Chronotype (morning person)	0.3	0.7	1.5	-0.3	1.2	0.8
Hand grip strength (left)	0.3	0.8	1.3	-0.4	1.1	1.0
Hearing difficulty/problems: Yes	0.3	0.5	0.9	-0.6	-1.0	-0.4
Leg fat-free mass (left)	0.3	1.4	1.6	1.1	1.1	1.3
Current tobacco smoking	0.3	0.5	1.2	-0.4	-1.1	0.1
Age when periods started (menarche)	0.3	0.7	1.0	-1.0	-0.7	-0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	-0.5	-0.3	-0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	-0.9	0.5	-0.0
Sitting height	0.3	1.9	4.4	-1.0	-2.1	-0.6
Leg predicted mass (left)	0.3	1.4	1.7	1.1	1.2	1.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-0.1	0.5	-1.0
Medication: Simvastatin	0.3	0.4	0.6	0.7	0.3	0.8
Lung cancer (father)	0.3	0.4	0.9	-0.9	0.5	-0.2
Breastfed as a baby	0.3	0.4	0.8	-0.9	0.1	-0.7
Loud music exposure frequency	0.3	0.3	0.8	-0.4	-0.9	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	1.0	0.2	0.8
Body fat percentage	0.3	1.3	2.0	-1.4	0.1	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.6	0.1	-0.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.0	-0.4	1.0	-0.2
Pulse rate, automated reading	0.3	0.9	1.4	-0.9	-1.2	-0.8
Family relationship satisfaction	0.3	0.4	1.1	1.0	-0.0	0.3
Medication: Aspirin	0.3	0.4	0.8	-0.3	0.9	-0.5
Illnesses of siblings: Diabetes	0.3	0.3	0.6	-0.8	-0.6	0.2
Whole body fat-free mass	0.3	1.5	2.7	1.0	1.0	1.6
Commuting to job workplace: Walk	0.3	0.3	0.8	-0.9	-0.1	-0.3
Eye problems/disorders: Cataract	0.3	0.4	0.9	-0.9	-0.5	-0.2
Medication: Aspirin	0.3	0.4	1.3	0.0	1.2	0.1
Whole body water mass	0.3	1.8	3.0	1.1	1.1	1.7
Hearing aid user	0.3	0.4	0.8	-0.4	-0.9	-0.5
Medication: Atorvastatin	0.3	0.3	1.0	-0.2	-0.1	-1.0
Commuting to job workplace: Cycle	0.3	0.3	0.5	0.7	0.1	0.7
Cholesterol lowering medication	0.3	0.4	0.8	0.3	-0.9	-0.4
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	-0.4	1.1	-0.1
Ovarian Cancer	0.2	0.3	0.7	-0.1	-0.8	-0.5
Fasting Glucose	0.2	0.3	0.7	0.4	-0.0	0.8
Blood Red Count	0.2	1.7	3.9	-0.6	-0.8	-2.0
Respiratory disease	0.2	0.5	1.5	-0.1	-0.3	1.2
Hair Pigment	0.2	5.1	6.3	-1.8	-2.4	-2.5
Relative age of first facial hair	0.2	0.4	0.5	0.4	-0.7	0.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	-0.4	-0.7	-0.2
Ever had hysterectomy (womb removed)	0.2	0.2	0.2	0.5	0.5	0.3
Medication for hormone replacement therapy	0.2	0.2	0.4	0.7	-0.4	-0.2
Medication: Metformin	0.2	0.2	0.5	0.3	0.7	0.4
Maternal smoking around birth	0.2	0.3	0.6	-0.4	0.8	0.0
Relative age voice broke	0.2	0.3	0.6	0.4	0.0	0.8
Waist circumference	0.2	0.6	1.1	-1.0	0.3	-0.8
Had other major operations	0.2	0.2	0.5	0.1	-0.7	-0.0
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.5	-0.8	-0.2
Trunk fat-free mass	0.2	1.3	2.9	0.8	0.6	1.7
Hip circumference	0.2	1.0	2.4	-1.5	0.2	-0.7
Time employed in main current job	0.2	0.2	0.3	-0.5	0.4	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	1.2	0.9	0.6	1.1
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.4	0.6	-0.2
Trunk predicted mass	0.2	1.3	2.8	0.8	0.6	1.7
Leg fat percentage (right)	0.2	0.8	1.1	-1.1	1.0	-0.7
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.6	-0.1	-0.5
Emphysema/chronic bronchitis	0.2	0.2	0.6	-0.1	-0.1	0.8
Migraine (self-reported)	0.2	0.2	0.6	-0.1	-0.0	-0.8
Heart disease (mother)	0.2	0.2	0.6	0.1	0.2	0.8
Leg fat mass (right)	0.2	0.7	2.0	-0.4	1.4	-0.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	0.7	0.2	0.5
Average weekly red wine intake	0.2	0.3	0.6	0.8	-0.2	0.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	0.6	0.5	0.3
Loneliness, isolation	0.2	0.2	0.3	0.5	-0.4	-0.6
Qualifications: nursing, teaching	0.2	0.2	0.4	0.4	0.4	0.7
Back pain experienced in last month	0.2	0.3	0.7	-0.5	-0.2	-0.8
Mineral and other dietary supplements	0.2	0.3	0.8	-0.9	-0.5	0.0
Financial situation satisfaction	0.2	0.2	0.6	0.1	-0.8	-0.0
Leg fat percentage (left)	0.2	0.8	1.3	-0.8	1.2	-0.5
Supplements: Calcium	0.2	0.2	0.5	-0.4	-0.1	-0.7
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	0.4	-0.8	0.3
Pack years of smoking	0.2	0.3	0.5	0.7	-0.4	0.4
Leg fat mass (left)	0.2	0.7	2.1	-0.2	1.4	0.1
Depression (Nagel 2018)	0.1	0.1	0.1	-0.3	-0.2	0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.4	-0.0	-0.6	-0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.1	-0.3	-0.3	-0.0
Rheumatoid Arthritis	0.1	0.2	0.3	0.1	-0.5	0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.4	0.3	-0.1
Systolic blood pressure, automated reading	0.1	0.2	0.3	-0.6	-0.5	-0.1
Diabetes (mother)	0.1	0.1	0.2	-0.1	-0.1	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.3	0.1	-0.6	0.3
Multivitamins +/- minerals	0.1	0.1	0.3	0.5	-0.2	0.2
Alcohol usually taken with meals	0.1	0.1	0.1	0.3	0.4	0.3
Forced vital capacity (FVC)	0.1	0.3	0.4	0.5	-0.6	0.7
Heart attack	0.1	0.2	0.3	-0.4	0.5	0.2
Allergy	0.1	0.1	0.2	0.5	0.2	-0.4
Weight	0.1	0.3	0.8	-0.2	0.9	0.2
Number of live births	0.1	0.2	0.3	-0.2	0.5	0.4
Pulse rate	0.1	0.2	0.5	0.7	0.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.0	-0.5	0.3
Depression (self-reported)	0.1	0.1	0.2	0.4	0.2	-0.5
Arm fat mass (right)	0.1	0.4	1.2	-0.2	1.1	0.2
Worry too long after embarrassment	0.1	0.1	0.4	-0.2	-0.6	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.3	-0.2	-0.6
Shortness of breath walking on level ground	0.1	0.1	0.2	0.0	-0.5	-0.0
Medication: Ibuprofen	0.1	0.2	0.3	-0.5	-0.0	-0.5
Medication: Omeprazole	0.1	0.1	0.1	-0.2	0.2	-0.4
Whole body fat mass	0.1	0.6	1.0	-1.0	0.4	-0.7
Knee pain experienced in last month	0.1	0.2	0.3	-0.5	-0.4	-0.1
Arm fat percentage (left)	0.1	0.3	0.7	-0.3	0.9	-0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.2	-0.8	-0.0
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	-0.3	-0.3	-0.6
Arm fat mass (left)	0.1	0.5	1.4	-0.2	1.2	0.2
Basal metabolic rate	0.1	0.7	1.3	0.5	0.8	1.1
Pain experienced in last month	0.1	0.2	0.3	0.3	0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.4	0.5	0.2
Blood Eosinophil Count	0.0	0.1	0.1	-0.2	0.3	0.3
Tanning	0.0	0.5	1.1	-0.4	1.1	0.3
Angina	0.0	0.0	0.1	-0.2	-0.1	-0.3
Supplements: Glucosamine	0.0	0.1	0.2	-0.0	-0.1	-0.4
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	-0.1	-0.3	-0.1
Arm fat percentage (right)	0.0	0.2	0.4	-0.2	0.7	-0.1
Peak expiratory flow (PEF)	0.0	0.0	0.0	0.2	0.0	0.2
Angina (self-reported)	0.0	0.0	0.0	-0.1	-0.0	-0.1
Breast cancer (self-reported)	0.0	0.0	0.1	-0.2	-0.2	-0.3
Miserableness	0.0	0.1	0.1	0.3	-0.0	-0.3
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	0.3	-0.1	-0.3

Hub : Genes

POM121

Models

Trait associations