Best TWAS P=3.28e-11 · Best GWAS P=4.02e-13 conditioned to 0.0558
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | MROH1 | 0.22 | 0.20 | lasso | 4 | 0.15 | 1.1e-04 | 6.5 | 6.6 | 3.9e-11 | 0.86 | 0.01 | 0.93 | FALSE |
2 | GTEx | Brain Cerebellum | GPT | 0.18 | 0.04 | enet | 18 | 0.07 | 4.2e-03 | -3.7 | -5.4 | 6.0e-08 | -0.39 | 0.05 | 0.28 | FALSE |
3 | GTEx | Breast Mammary Tissue | RP13-582O9.5 | 0.18 | 0.12 | lasso | 6 | 0.13 | 2.8e-07 | -4.1 | 5.2 | 2.0e-07 | 0.12 | 0.02 | 0.97 | FALSE |
4 | GTEx | Breast Mammary Tissue (Male) | RP13-582O9.5 | 0.05 | 0.05 | lasso | 1 | -0.01 | 4.9e-01 | -5.3 | 5.3 | 1.2e-07 | 0.10 | 0.02 | 0.36 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | GS1-393G12.12 | 0.09 | 0.05 | lasso | 4 | 0.03 | 9.8e-03 | 6.5 | 6.6 | 3.3e-11 | 0.83 | 0.01 | 0.85 | TRUE |
6 | GTEx | Testis | ZFP41 | 0.13 | 0.14 | lasso | 1 | 0.10 | 2.3e-05 | -5.3 | -5.3 | 1.4e-07 | -0.10 | 0.01 | 0.99 | FALSE |
7 | GTEx | Testis | GLI4 | 0.14 | 0.03 | enet | 11 | 0.10 | 2.2e-05 | -5.2 | -5.9 | 3.4e-09 | -0.12 | 0.02 | 0.97 | TRUE |
8 | GTEx | Thyroid | BOP1 | 0.19 | 0.10 | enet | 12 | 0.15 | 8.8e-12 | 7.3 | 5.8 | 7.0e-09 | 0.91 | 0.00 | 1.00 | FALSE |
9 | METSIM | Adipose | ZNF696 | 0.07 | 0.06 | lasso | 8 | 0.05 | 5.0e-08 | -5.2 | -5.2 | 1.5e-07 | -0.11 | 0.01 | 0.99 | FALSE |
10 | ROSMAP | Brain Pre-frontal Cortex | ZFP41 | 0.09 | 0.08 | lasso | 6 | 0.06 | 1.9e-08 | -5.2 | 5.2 | 1.6e-07 | 0.11 | 0.01 | 0.99 | FALSE |