Hub : Genes

GLI4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0960	0.0340	6.8e-04	0.007	0.026	0.016	0.028	0.016	4.4e-02	3.7e-04	4.0e-03	2.0e-04	3.8e-03
2	GTEx	Testis	0.1410	0.0480	6.6e-04	0.032	NA	0.105	NA	0.088	1.5e-02	NA	2.2e-05	NA	1.0e-04
3	ROSMAP	Brain Pre-frontal Cortex	0.0738	0.0229	5.4e-06	0.052	0.043	0.048	0.044	0.048	3.0e-07	2.6e-06	8.5e-07	2.1e-06	7.0e-07
4	TCGA	Breast Invasive Carcinoma	0.0137	0.0082	6.6e-04	0.019	0.017	0.019	NA	0.019	6.5e-05	1.3e-04	5.5e-05	NA	6.5e-05
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0381	0.0334	9.9e-03	0.022	0.020	0.034	NA	0.028	1.5e-03	2.1e-03	8.7e-05	NA	4.0e-04
6	TCGA	Brain Lower Grade Glioma	0.0218	0.0126	7.2e-04	0.029	0.025	0.023	NA	0.027	2.5e-04	6.0e-04	9.7e-04	NA	3.9e-04
7	TCGA	Ovarian Serous Cystadenocarcinoma	0.0450	0.0280	1.5e-03	0.060	0.035	0.044	NA	0.047	6.8e-05	2.1e-03	6.1e-04	NA	3.7e-04
8	TCGA	Prostate Adenocarcinoma	0.0247	0.0139	8.1e-04	0.025	0.025	0.023	NA	0.025	1.2e-03	1.1e-03	1.6e-03	NA	1.2e-03
9	TCGA	Thyroid Carcinoma	0.0400	0.0240	2.4e-04	0.036	0.031	0.011	NA	0.023	1.9e-04	5.0e-04	2.5e-02	NA	2.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.8	1.2	2.3	-0.5	1.1	1.2	-0.9	-0.3	-1.5	-1.5	-1.2	-1.1
Bipolar Disorder or Schizophrenia	0.2	0.4	1.6	-0.1	0.4	0.9	-0.1	-0.2	-0.9	-1.3	-0.4	-0.3
Depressed Affect (Nagel 2018)	0.1	0.3	0.9	0.9	0.9	0.6	0.3	0.5	-0.3	-0.4	0.0	0.3
Depression (Nagel 2018)	0.3	0.4	0.8	0.3	-0.6	-0.4	0.6	0.8	0.7	0.6	0.8	0.9
Intelligence (Savage-Jansen 2018)	0.7	2.1	5.3	-0.0	-2.3	-1.6	1.1	1.9	1.3	0.9	1.5	1.3
Neuroticism (Nagel 2018)	0.3	0.7	2.6	1.6	-0.1	0.1	0.4	1.1	0.4	0.2	0.8	1.0
Schizophrenia (2018)	0.1	0.1	0.3	0.3	-0.4	0.2	0.6	0.0	0.0	-0.4	0.4	0.4
Schizophrenia vs Biploar Disorder	0.7	0.9	4.6	2.1	0.4	0.3	0.3	-1.6	0.5	0.4	0.6	0.5
Worry (Nagel 2018)	0.4	0.9	2.3	1.3	-0.1	0.0	0.5	1.4	0.5	0.5	1.2	1.5
Alzheimer’s Disease (in mother)	1.3	1.5	4.8	1.8	1.6	1.1	-0.1	-2.2	-0.9	-0.8	-0.7	-0.5
Alzheimer’s Disease (in father)	3.3	3.6	5.8	0.6	2.1	1.8	-1.5	-2.4	-2.0	-2.0	-1.9	-2.0
Alzheimer’s Disease (including proxy)	1.2	1.8	5.3	2.0	1.8	1.0	-0.3	-2.3	-0.9	-0.8	-0.7	-0.6
Crohns Disease (2017)	0.5	1.1	1.8	0.1	1.3	1.3	-1.2	-0.8	-1.1	-1.0	-1.2	-1.1
Irritable Bowel Disease (IBD)	0.8	1.9	3.0	-0.3	1.3	1.2	-1.7	-1.5	-1.2	-1.1	-1.6	-1.7
Ulcerative Colitis (UC)	0.3	0.6	1.3	-0.9	0.3	0.1	-0.9	-1.1	-0.2	-0.2	-0.8	-1.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.2	2.3	3.2	0.7	1.3	1.7	-1.8	-1.8	-1.5	-1.6	-1.5	-1.6
Verbal and Numeric Reasoning (VNR)	1.3	3.1	9.1	0.9	-1.5	-1.4	1.7	3.0	1.2	1.0	2.0	2.2
Breast Cancer	0.3	0.6	1.4	-1.2	0.8	0.3	-0.4	-1.0	-0.6	-0.3	-1.0	-1.0
Ovarian Cancer	0.4	0.5	2.0	0.8	1.4	0.7	-0.6	-0.5	-0.5	-0.3	-0.7	-0.5
Prostate Cancer	0.4	0.6	1.7	-0.1	-0.0	0.4	-0.9	1.3	-0.7	-1.0	-0.6	-0.7
Age at First Birth	0.3	0.5	1.3	-0.6	-0.1	0.9	-0.8	0.5	-0.8	-1.1	-0.4	-0.5
Bipolar Disorder (2011)	5.4	5.2	8.4	0.0	0.0	2.2	-2.8	-2.1	-2.7	-2.5	-2.9	-2.9
Body Mass Index (BMI) (2010)	1.9	2.6	4.1	0.7	1.9	2.0	-1.4	-1.6	-1.7	-1.6	-1.6	-1.5
Coronary Artery Disease (CAD)	1.2	1.4	2.8	0.7	1.4	1.6	-1.0	-0.7	-1.4	-1.7	-0.9	-0.7
Crohns Disease (2012)	0.8	1.3	2.3	-0.5	0.7	1.1	-1.5	-1.1	-1.0	-1.1	-1.4	-1.5
Mean Putamen Volume	0.7	0.8	1.8	-0.2	0.7	1.1	-1.3	-0.8	-0.8	-0.8	-1.0	-1.1
Fasting Glucose	0.2	0.3	1.1	-0.3	0.3	-0.3	-0.1	-1.1	0.0	0.5	-0.6	-0.5
HbA1C	1.1	1.3	3.0	1.7	-0.2	-1.0	1.3	0.2	1.2	1.3	1.1	1.2
HDL Cholesterol	1.3	2.2	9.2	3.0	0.1	-0.4	1.4	0.5	1.1	1.2	1.6	1.9
LDL Cholesterol	0.5	0.8	5.0	-2.2	-0.5	0.0	-0.4	0.7	-0.5	-0.6	-0.7	-0.8
Lupus	0.5	0.8	1.4	0.3	1.1	1.0	-0.6	-1.2	-1.0	-1.0	-0.8	-0.7
Neuroticism (2016)	1.4	2.0	4.0	1.4	1.9	2.0	-1.4	-0.1	-1.5	-1.5	-1.1	-0.6
Primary Biliary Cirrhosis	0.2	0.2	0.5	0.5	-0.7	-0.2	-0.7	0.7	0.1	-0.1	-0.2	-0.4
Rheumatoid Arthritis	0.4	0.6	4.1	-2.0	-0.5	-0.7	0.6	-0.2	0.3	0.4	0.1	-0.2
Schizophrenia (2014)	0.1	0.2	0.5	0.7	-0.1	0.3	0.5	0.4	0.1	-0.3	0.6	0.7
Triglycerides	0.6	1.0	1.8	-0.9	0.2	0.9	-1.3	-0.5	-1.0	-1.2	-1.1	-1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.8	0.6	1.3	0.9	-0.2	-0.3	-0.6	-0.6	-0.4	-0.3
Ulcerative Colitis	2.2	3.2	5.8	-1.1	1.4	1.3	-2.1	-2.1	-1.4	-1.4	-2.2	-2.4
Blood Eosinophil Count	0.3	2.6	6.4	-1.5	0.7	0.6	-1.8	-0.6	-1.7	-1.1	-2.4	-2.5
Blood Platelet Count	0.0	0.4	1.0	0.9	0.7	0.2	1.0	-0.2	0.3	0.4	0.6	0.9
Blood Red Count	1.2	11.7	31.0	1.5	4.4	3.7	-2.2	-5.6	-3.0	-2.5	-3.2	-3.0
Blood White Count	0.8	6.1	9.2	-0.5	1.8	2.4	-2.8	-2.6	-2.6	-2.4	-3.0	-3.0
Heel T-Score	0.1	0.9	2.6	-0.3	1.6	0.9	-0.7	0.8	-1.3	-0.9	-1.1	-0.6
BMI	2.2	13.0	17.4	-0.9	3.4	3.8	-3.6	-4.2	-3.8	-3.4	-4.1	-4.2
Height	4.3	82.9	151.3	-3.9	-12.3	-10.5	7.1	9.3	10.0	9.7	8.8	7.7
Waist Hip Ratio (WHR)	0.0	0.1	0.7	0.6	0.1	-0.1	-0.9	0.0	-0.1	-0.2	-0.3	-0.2
Systolic Blood Pressure	0.4	1.8	5.1	-1.0	2.2	1.4	-0.5	-1.9	-1.1	-1.1	-0.9	-0.8
Smoking Status	1.3	3.2	9.6	3.1	2.0	1.9	-0.9	-2.0	-1.5	-1.3	-1.3	-1.0
Allergy or Eczema	0.2	0.5	1.5	0.2	0.7	0.5	0.1	-1.2	-0.7	-0.4	-0.8	-0.8
Cardiovascular Disease	0.5	1.6	4.2	-0.8	1.7	1.3	-0.7	-2.0	-1.1	-0.9	-1.2	-1.1
Hypothyroidism (self reported)	0.1	0.2	0.3	0.2	-0.4	-0.3	0.5	-0.4	0.6	0.5	0.4	0.3
Respiratory disease	1.3	3.0	6.0	-0.3	1.3	1.7	-1.7	-0.6	-2.3	-2.5	-1.9	-1.9
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.5	-1.2	-0.8	0.1	0.3	-0.4	0.2	0.3	0.3	0.2
Lung FEV1/FVC ratio	0.6	3.2	6.1	-0.7	-1.7	-2.5	1.8	1.6	2.0	2.1	1.5	1.4
Lung FVC	0.1	0.3	2.1	0.0	1.4	0.0	0.4	0.1	-0.5	-0.2	-0.4	-0.0
Neuroticism	0.3	0.8	2.6	1.6	-0.2	-0.2	0.6	1.0	0.5	0.4	1.0	1.3
Chronotype (morning person)	0.1	0.2	0.9	-0.4	-0.6	-0.3	-0.1	-1.0	0.5	0.3	0.3	-0.0
Hair Pigment	0.0	0.3	1.2	-0.4	-0.5	-0.4	-0.2	1.1	0.4	0.5	0.1	0.3
Tanning	0.3	3.5	12.6	3.5	2.4	1.8	-0.5	-2.3	-1.1	-1.0	-0.9	-0.8
Hand grip strength (left)	0.7	1.8	3.4	0.1	-0.8	-1.3	1.4	1.2	1.5	1.8	1.6	1.7
Number of treatments/medications taken	0.3	0.6	1.4	0.2	1.0	1.2	-0.1	-0.7	-0.9	-0.8	-0.7	-0.4
Average weekly spirits intake	0.6	0.8	1.6	0.4	-1.0	-1.2	0.6	1.3	0.9	0.8	0.7	0.6
Sensitivity / hurt feelings	1.6	2.7	3.7	1.1	-1.4	-1.4	1.8	1.9	1.7	1.6	1.8	1.9
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	0.2	-0.8	-0.6	0.1	0.5	0.4	0.4	0.1	0.1
Hearing difficulty/problems: Yes	0.3	0.5	1.8	-1.2	-0.8	-0.6	0.3	1.4	0.1	-0.1	0.2	0.1
Relative age of first facial hair	0.3	0.6	3.5	1.9	0.7	0.3	-0.0	-1.2	0.3	0.3	0.0	0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.8	-0.8	-0.0	-0.5	0.3	0.9	0.2	0.2	0.1	0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.5	0.6	0.7	0.3	0.3	0.4	-0.2	0.0	0.2	0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.5	0.2	0.4	0.7	-0.3	0.2	-0.7	-0.5	-0.7	-0.5
Systolic blood pressure, automated reading	0.8	2.2	6.5	-0.2	2.5	1.8	-0.6	-2.3	-1.3	-1.1	-1.1	-0.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.9	1.4	-0.6	-1.0	1.0	0.3	1.1	1.3	1.0	1.0
Angina	1.0	1.3	3.1	1.0	1.8	1.0	-1.3	-0.6	-1.0	-0.6	-1.3	-1.0
Medication for hormone replacement therapy	0.2	0.2	0.7	0.4	-0.9	-0.4	-0.3	-0.7	0.2	0.4	0.2	0.1
Vitamin and mineral supplements	0.5	0.7	1.6	-0.4	-1.2	-1.3	0.3	1.2	0.6	0.6	0.5	0.5
Supplements: Zinc	0.5	0.5	3.1	0.8	-0.2	0.5	-0.4	-1.8	-0.2	-0.3	-0.4	-0.5
Medication: Co-codamol	0.3	0.3	1.4	-1.2	0.5	0.0	-0.3	0.1	-0.5	-0.3	-0.6	-0.5
Medication: Metformin	0.2	0.2	0.9	-0.4	-0.9	-0.2	0.2	0.9	0.1	0.2	0.2	0.3
Diabetes (father)	0.9	1.1	2.2	-1.5	-1.5	-1.3	0.7	0.1	1.0	1.1	0.7	0.6
Diabetes (mother)	0.9	1.1	2.0	-0.8	1.2	1.2	-0.8	-0.1	-1.3	-1.4	-1.1	-1.1
Severe depression (siblings)	0.9	1.0	1.7	0.5	-0.8	-1.1	1.0	1.3	1.2	1.1	1.0	0.9
Pack years adult smoking proportion	0.1	0.2	0.5	0.7	-0.5	-0.6	-0.1	0.4	0.3	0.5	0.2	0.1
Impedance of leg (right)	0.3	1.5	3.1	0.3	-1.2	-1.8	1.1	0.5	1.6	1.4	1.3	1.1
Leg fat-free mass (left)	0.7	3.6	8.4	-2.3	-2.9	-2.0	0.9	1.9	1.8	2.0	1.5	1.1
Trunk fat percentage	0.3	1.3	2.7	-1.4	-0.5	0.8	-1.5	-0.5	-0.9	-0.9	-1.3	-1.6
Hand grip strength (right)	1.9	5.2	7.1	-0.6	-1.8	-2.3	2.4	2.5	2.5	2.7	2.6	2.5
Townsend deprivation index at recruitment	0.2	0.3	1.3	0.2	0.7	0.0	-0.2	-1.1	-0.5	-0.5	-0.4	-0.4
Current tobacco smoking	1.5	2.5	4.3	1.9	2.1	1.7	-1.4	-1.0	-1.7	-1.5	-1.6	-1.3
Average weekly fortified wine intake	0.4	0.4	0.9	1.0	-0.9	-0.7	0.2	-0.7	0.6	0.7	0.3	0.2
Maternal smoking around birth	1.0	1.5	3.1	1.4	0.2	-0.8	1.1	1.8	1.0	1.2	1.3	1.6
Fed-up feelings	0.3	0.5	1.7	-0.7	-1.3	-0.9	-0.1	0.6	0.7	0.6	0.2	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	3.7	1.1	-1.2	-1.5	1.5	1.3	1.8	1.8	1.7	1.9
Relative age voice broke	0.0	0.1	0.3	0.5	-0.2	-0.1	0.2	-0.5	0.2	0.2	0.1	0.0
Taking other prescription medications	0.1	0.2	0.3	0.6	0.5	0.3	-0.1	-0.4	-0.4	-0.2	-0.5	-0.4
Age when periods started (menarche)	3.3	7.9	12.5	0.9	-2.5	-2.7	3.5	1.8	3.3	3.1	3.2	3.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.8	0.4	0.3	0.7	-0.9	0.3	-0.8	-0.8	-0.9	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.2	-1.5	1.5	0.9	-1.6	-0.3	-1.6	-1.3	-1.8	-1.6
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.3	-0.8	-0.1	1.1	-0.9	-0.7	-0.9	-0.9	-0.9	-1.0
Qualifications: CSEs or equivalent	0.1	0.1	0.4	-0.5	0.5	-0.7	0.0	-0.2	0.0	0.2	-0.2	-0.1
Serious illness, injury or assault to yourself	0.3	0.3	1.8	-0.5	-1.3	-0.4	-0.3	-0.7	0.0	-0.2	-0.1	-0.3
High blood pressure	0.8	2.3	5.9	0.0	2.4	1.8	-0.4	-2.4	-1.4	-1.3	-1.2	-1.0
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.8	-0.1	0.3	0.2	0.1	-0.9	-0.2	-0.1	-0.4	-0.5
Multivitamins +/- minerals	1.1	1.3	3.0	1.5	1.7	1.5	-0.1	-1.6	-0.8	-0.7	-0.5	-0.4
Stomach or abdominal pain in last month	0.8	1.0	1.6	0.3	-0.8	-1.1	1.3	1.1	1.2	1.0	1.0	1.0
Supplements: Glucosamine	1.1	1.5	3.2	0.5	1.5	1.8	-0.6	-0.8	-1.5	-1.4	-1.2	-0.9
Diverticular disease/diverticulitis (self-reported)	4.1	4.8	7.0	0.2	1.9	2.0	-2.6	-2.2	-2.2	-2.3	-2.7	-2.6
Medication: Atenolol	0.5	0.6	2.0	-0.8	0.6	0.4	-0.6	-1.4	-0.7	-0.5	-0.9	-0.8
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.2	0.4	0.3	-0.3	-0.2	-0.3	-0.2	-0.5	-0.5
Sitting height	1.5	10.7	17.6	0.3	-4.2	-3.7	3.0	2.5	3.8	3.8	3.5	3.0
Chronic bronchitis/emphysema (father)	0.5	0.6	1.5	-0.5	1.0	1.2	0.2	-1.0	-0.9	-0.7	-0.5	-0.2
High blood pressure (mother)	0.3	0.5	0.7	-0.7	0.8	0.4	-0.4	0.2	-0.8	-0.8	-0.8	-0.8
Body mass index (BMI)	2.4	10.0	13.2	-0.5	3.1	3.6	-3.3	-3.1	-3.5	-3.1	-3.5	-3.5
Impedance of leg (left)	0.2	1.1	1.9	0.8	-0.9	-1.4	1.1	-0.2	1.4	1.2	1.1	0.9
Leg predicted mass (left)	0.7	3.9	8.9	-2.3	-3.0	-2.1	0.9	2.0	1.9	2.1	1.6	1.2
Trunk fat mass	0.2	0.8	2.2	-1.5	-0.9	0.4	-1.2	-0.3	-0.5	-0.4	-0.9	-1.3
Waist circumference	0.6	2.1	3.9	-1.3	0.3	1.3	-1.9	-1.5	-1.3	-1.1	-1.7	-2.0
Number of incorrect matches in round	4.6	7.7	11.3	1.8	3.3	3.4	-2.4	-2.6	-3.0	-3.1	-2.7	-2.4
Past tobacco smoking	0.9	1.7	7.9	-2.8	-1.5	-1.2	-0.0	1.8	0.6	0.7	0.4	0.2
Alcohol usually taken with meals	0.1	0.1	0.3	0.6	0.2	-0.0	0.3	-0.5	0.3	0.3	0.2	0.2
Nervous feelings	0.6	1.1	2.4	-1.6	-1.6	-0.6	0.1	1.1	1.0	0.8	0.9	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.5	-1.0	-1.6	-1.0	0.1	0.7	0.8	0.7	0.5	0.3
Hearing difficulty/problems with background noise	3.0	4.8	8.6	-2.7	-2.9	-2.3	1.7	2.8	1.8	1.6	1.7	1.6
Hair/balding pattern: Pattern 2	1.1	1.4	4.9	-2.2	-0.6	0.0	-1.3	-0.5	-0.9	-1.1	-1.2	-1.5
Had menopause	1.5	1.8	3.7	0.6	0.7	1.9	-1.6	-0.9	-1.5	-1.7	-1.4	-1.3
Had other major operations	1.7	2.0	3.8	-0.8	0.6	1.3	-1.7	-0.3	-1.7	-1.6	-2.0	-1.9
Forced vital capacity (FVC)	1.6	6.1	12.3	-0.6	-2.8	-3.5	1.9	2.6	2.7	2.8	2.3	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.0	-0.5	1.7	1.2	-1.4	-0.1	-1.6	-1.3	-1.5	-1.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.9	0.2	-1.4	-1.2	0.4	1.0	0.9	0.8	0.7	0.6
Qualifications: None of the above	0.4	0.8	1.2	-0.2	1.1	1.0	-0.9	0.1	-1.0	-1.0	-1.0	-0.8
Financial difficulties in last 2 years	0.3	0.4	1.0	0.5	0.7	0.8	-0.3	-1.0	-0.4	-0.2	-0.5	-0.4
Mouth/teeth dental problems	1.4	2.2	3.4	0.6	-1.7	-1.8	1.3	1.0	1.8	1.8	1.5	1.4
Heart attack	1.0	1.3	3.8	2.0	1.3	1.2	-0.4	-1.6	-0.7	-0.8	-0.7	-0.5
Allergy	0.7	1.5	3.0	0.3	-1.1	-1.0	1.1	1.7	1.2	1.1	1.5	1.6
Pain all over the body in last month	1.0	1.1	4.8	0.1	1.4	1.2	-0.2	-2.2	-0.7	-0.5	-0.7	-0.5
Diabetes (self-reported)	0.4	0.5	1.3	-0.6	-1.2	-0.7	0.9	-0.2	0.7	0.9	0.6	0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.7	0.8	0.5	-0.2	-0.4	-0.6	-0.5	-0.6	-0.6
Medication: Ramipril	2.7	3.4	7.3	-2.7	0.7	1.4	-2.1	-0.5	-1.9	-2.0	-2.1	-2.1
Medication: Simvastatin	0.9	1.3	2.1	-0.5	0.6	1.1	-1.3	-1.1	-1.3	-1.2	-1.4	-1.4
Fluid intelligence score	0.6	1.2	4.4	0.7	-1.2	-0.7	0.9	2.1	0.6	0.4	1.2	1.2
Illnesses of siblings	1.1	1.5	2.7	0.2	-1.4	-1.4	1.3	0.5	1.5	1.6	1.2	1.0
Neuroticism score	0.2	0.4	2.5	1.6	0.2	0.4	0.1	0.3	0.0	-0.1	0.5	0.7
Weight	0.1	0.6	2.4	-1.5	-1.1	0.0	-0.8	-0.2	-0.0	0.2	-0.4	-0.8
Impedance of arm (right)	3.4	16.0	34.9	-1.4	-5.9	-4.7	3.0	4.0	4.4	3.7	3.9	3.3
Arm fat percentage (right)	0.9	3.7	6.4	-1.3	0.6	1.9	-2.4	-1.6	-2.0	-2.0	-2.3	-2.5
Trunk fat-free mass	0.6	3.5	6.6	-0.9	-2.6	-2.0	1.3	1.5	2.1	2.4	1.9	1.6
Hip circumference	0.2	1.1	4.7	-2.2	-1.8	-0.6	-0.6	-0.0	0.4	0.7	-0.2	-0.7
Time employed in main current job	1.5	1.7	3.1	0.5	-1.6	-1.2	1.1	-0.1	1.8	1.7	1.5	1.3
Alcohol intake versus 10 years previously	2.6	3.9	5.2	0.8	1.5	2.1	-2.0	-2.2	-2.1	-2.3	-2.2	-2.2
Father’s age at death	0.3	0.4	1.1	0.3	0.3	0.5	-0.7	-0.2	-0.8	-1.1	-0.4	-0.4
Worrier / anxious feelings	0.2	0.4	1.2	1.1	0.4	0.8	0.2	0.3	-0.2	-0.4	0.6	0.8
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	9.3	-1.6	-3.0	-2.7	1.4	2.4	2.0	1.7	1.8	1.6
Falls in the last year	0.5	0.6	2.6	-1.6	0.0	0.3	-0.5	-0.8	-0.5	-0.5	-0.8	-1.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	-0.0	0.3	0.7	-0.4	-0.6	-0.6	-0.5	-0.7	-0.6
Number of live births	6.2	8.8	17.2	-2.4	-2.8	-3.0	2.5	4.1	2.9	2.8	2.8	2.9
Forced expiratory volume in 1-second (FEV1)	2.5	8.3	16.9	-1.1	-3.0	-4.1	2.4	2.9	3.2	3.2	2.7	2.4
Pulse rate	2.3	3.9	5.2	-0.9	-2.3	-2.0	2.0	1.8	2.1	2.3	2.0	1.9
Happiness	0.5	0.6	1.7	-0.4	-1.1	-0.9	0.2	1.3	0.6	0.4	0.6	0.4
Noisy workplace	0.7	0.9	1.8	-0.5	0.9	0.3	-1.3	0.9	-1.1	-1.0	-1.1	-0.9
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.5	0.7	-0.2	0.3	0.2	-0.0	-0.2	-0.1	0.1	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.7	-0.4	-1.3	-1.0	0.5	0.5	0.7	0.6	0.5	0.4
Mouth/teeth dental problems: Dentures	1.5	2.6	4.2	-0.4	2.1	2.0	-1.1	-1.7	-1.8	-1.7	-1.6	-1.5
Asthma	0.7	1.5	2.0	-0.7	1.2	1.2	-1.0	-1.1	-1.3	-1.3	-1.4	-1.4
Medication: Ibuprofen (e.g. Nurofen)	3.1	3.9	7.9	0.7	2.8	2.1	-1.8	-1.8	-2.2	-2.0	-2.1	-1.7
Medication: Cholesterol lowering	1.3	2.1	3.1	1.1	1.4	1.7	-1.3	-0.9	-1.7	-1.5	-1.8	-1.5
Depression (self-reported)	0.4	0.5	1.1	0.6	0.0	-0.5	0.9	0.3	0.6	0.8	0.7	1.1
Medication: Lansoprazole	0.8	0.9	1.8	0.2	0.6	1.0	-1.3	-1.0	-0.8	-0.8	-1.2	-1.2
Prospective memory result	0.5	0.6	1.7	1.0	0.9	0.7	-0.7	-1.3	-0.5	-0.3	-0.7	-0.6
Lung cancer (father)	1.3	1.5	3.2	0.3	1.8	1.4	-1.4	-0.7	-1.3	-1.1	-1.2	-1.1
Illnesses of mother	0.3	0.4	1.2	0.3	-1.1	-0.5	0.4	0.2	0.6	0.5	0.7	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	3.7	11.8	21.1	-0.5	-3.6	-4.6	3.1	2.7	4.1	4.1	3.5	3.0
Pulse wave Arterial Stiffness index	8.8	10.2	16.3	1.2	3.1	4.0	-3.0	-3.4	-3.4	-3.4	-3.3	-3.0
Impedance of arm (left)	2.9	13.3	29.8	-1.1	-5.5	-4.3	2.6	4.2	3.9	3.2	3.5	2.9
Arm fat mass (right)	0.5	2.1	3.7	-1.4	0.2	1.4	-1.8	-1.2	-1.4	-1.2	-1.7	-1.9
Trunk predicted mass	0.6	3.6	6.5	-0.8	-2.6	-2.1	1.3	1.5	2.1	2.4	2.0	1.7
Standing height	4.4	43.5	80.6	-2.2	-9.0	-7.6	5.0	6.4	7.3	7.2	6.6	5.7
Length of working week for main job	1.4	1.5	2.4	0.7	1.0	1.3	-1.6	-0.8	-1.5	-1.4	-1.3	-1.3
Exposure to tobacco smoke at home	1.1	1.2	2.1	0.7	1.5	1.0	-1.3	-0.4	-1.1	-1.1	-1.3	-1.2
Breastfed as a baby	0.7	0.9	3.4	-1.4	-1.8	-0.7	0.5	1.2	0.6	0.3	0.6	0.2
Tense / ‘highly strung’	1.0	1.7	3.8	1.9	1.2	1.5	-1.4	-1.0	-1.2	-1.2	-1.0	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.1	-0.3	0.9	1.1	-1.3	-0.7	-1.4	-1.4	-1.4	-1.2
Hair/balding pattern: Pattern 4	0.7	1.6	2.6	1.0	-1.0	-1.0	1.3	1.2	1.3	1.3	1.6	1.6
Birth weight of first child	0.8	1.5	3.2	-0.6	0.3	0.8	-1.7	-0.6	-1.3	-1.4	-1.6	-1.8
Peak expiratory flow (PEF)	3.6	8.3	14.9	-2.1	-3.2	-3.9	2.1	3.2	3.0	2.8	2.8	2.4
Pulse wave reflection index	11.4	14.1	19.0	0.7	3.7	4.2	-3.9	-3.4	-4.4	-4.3	-4.1	-3.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	3.3	1.8	-0.1	-0.3	-1.0	-0.6	0.1	0.2	-0.5	-0.6
Loud music exposure frequency	0.4	0.4	2.7	1.6	-0.2	0.1	0.3	-0.8	0.2	0.4	0.1	0.1
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	5.7	-0.4	-2.1	-1.8	1.2	2.4	1.6	1.6	1.7	1.6
Mouth/teeth dental problems: Bleeding gums	2.6	3.3	5.2	0.9	1.1	2.3	-2.1	-1.5	-2.0	-2.1	-1.9	-1.9
Blood clot in the leg (DVT)	0.8	1.1	1.8	-0.3	0.6	0.9	-1.3	-1.0	-1.1	-1.1	-1.3	-1.3
Medication: Paracetamol	0.3	0.4	2.0	1.4	0.1	-0.0	0.5	-0.1	0.5	0.6	0.6	0.8
Headache pain in last month	1.3	2.2	3.5	1.6	-0.9	-1.2	1.4	1.1	1.6	1.5	1.8	1.9
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.6	-0.2	-1.5	-1.6	0.8	1.1	1.3	1.2	1.3	1.0
Glaucoma (self-reported)	1.9	2.2	12.8	-3.6	-1.8	-0.8	-0.9	0.0	-0.1	-0.2	-0.7	-1.3
Gout (self-reported)	1.8	2.5	3.7	0.1	1.3	1.8	-1.9	-1.0	-1.9	-1.7	-1.9	-1.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.3	0.7	0.6	-0.3	-0.6	-0.3	-0.2	-0.5	-0.4
Medication: Amlodipine	0.4	0.6	1.3	1.1	0.2	-0.1	1.1	0.1	0.6	0.7	0.8	1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.6	1.6	0.4	0.1	0.6	-0.6	0.3	0.5	0.3	0.3
Birth weight	1.0	2.2	5.0	0.0	-0.1	1.1	-2.2	0.4	-1.7	-2.0	-1.7	-1.9
Chronic bronchitis/emphysema (mother)	0.9	1.1	3.9	1.4	2.0	1.3	-0.2	-1.0	-0.8	-0.6	-0.5	-0.3
High blood pressure (siblings)	0.7	1.1	2.2	-0.3	1.5	1.3	-0.6	-1.1	-1.2	-1.3	-0.8	-0.6
Forced vital capacity (FVC), Best measure	2.1	7.7	13.6	-0.2	-3.1	-3.7	2.5	2.1	3.3	3.4	2.8	2.4
Body fat percentage	1.1	4.4	7.7	-1.2	0.9	2.1	-2.5	-2.0	-2.2	-2.1	-2.5	-2.8
Leg fat percentage (right)	3.5	12.7	16.7	-0.6	3.2	3.8	-3.8	-3.8	-3.9	-3.6	-4.1	-4.1
Arm fat-free mass (right)	0.1	0.7	1.6	-0.9	-1.0	-0.8	0.4	0.3	0.8	1.3	0.7	0.5
Exposure to tobacco smoke outside home	1.4	1.9	4.0	1.8	2.0	1.5	-0.8	-1.4	-1.4	-1.1	-1.1	-0.8
Comparative body size at age 10	1.7	4.6	7.9	0.4	2.1	2.6	-1.8	-2.8	-2.3	-2.0	-2.2	-2.2
Number of full brothers	1.4	1.8	3.7	-0.6	0.3	0.8	-1.9	-1.1	-1.4	-1.4	-1.7	-1.9
Worry too long after embarrassment	2.2	3.8	6.0	0.5	-1.6	-1.8	2.3	1.6	2.1	1.9	2.5	2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.6	1.3	0.9	-0.1	0.4	0.4	-0.2	-0.1	-0.0	0.3
Wheeze or whistling in the chest in last year	2.0	3.6	4.5	1.3	1.7	1.8	-1.9	-2.1	-1.9	-2.0	-2.1	-2.1
Number of children fathered	2.0	2.3	3.5	-1.5	1.1	1.1	-1.9	0.5	-1.8	-1.5	-1.8	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	-0.2	1.1	0.8	-0.5	-0.3	-0.8	-0.7	-0.8	-0.7
Age at first live birth	0.5	0.9	2.0	0.9	-1.4	-0.9	1.1	0.6	0.9	0.7	1.1	0.9
Pulse wave peak to peak time	10.3	12.1	18.9	-1.4	-3.6	-4.3	3.2	3.7	3.8	3.8	3.6	3.2
Health satisfaction	0.2	0.2	0.6	-0.4	0.7	0.2	0.3	-0.8	-0.5	-0.3	-0.4	-0.2
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.3	-0.3	0.3	-0.4	-0.4	-0.3	-0.2	-0.3	-0.6
Qualifications: College or University degree	0.1	0.2	1.3	0.1	-0.1	-0.1	0.0	-1.1	-0.2	0.1	-0.4	-0.5
Eye problems/disorders: None of the above	2.2	2.5	6.2	2.5	2.2	1.5	-1.0	-1.7	-1.2	-1.3	-1.0	-1.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.7	1.3	0.8	0.7	-0.4	-1.1	-0.7	-0.5	-0.7	-0.5
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.2	-0.1	0.1	-0.4	-0.1	-0.1	-0.3	-0.2	-0.6
Medication for pain relief, constipation, heartburn	1.8	3.2	8.6	-1.8	-2.3	-2.0	0.8	2.9	1.4	1.1	1.5	1.1
Neck or shoulder pain in last month	0.1	0.2	0.6	0.5	-0.8	0.1	-0.4	0.7	-0.2	-0.4	-0.0	-0.0
Medication: Blood pressure	0.6	1.1	2.2	-0.1	1.3	1.4	-0.7	-1.5	-1.0	-1.0	-1.0	-0.8
Angina (self-reported)	1.1	1.4	3.4	1.2	1.8	1.1	-1.3	-0.8	-1.1	-0.6	-1.3	-1.0
Migraine (self-reported)	2.4	3.0	4.8	-1.6	-2.2	-1.9	1.2	1.6	1.8	1.6	1.7	1.6
Medication: Ibuprofen	3.5	4.2	5.9	0.5	2.4	2.2	-2.0	-2.0	-2.3	-2.2	-2.1	-1.9
Medication: Allopurinol	1.8	2.4	4.4	-0.7	0.4	1.1	-1.9	-1.3	-1.8	-1.6	-2.0	-2.1
Medication: Omeprazole	1.6	1.9	2.9	-0.9	1.3	1.0	-1.6	-1.5	-1.4	-1.3	-1.7	-1.7
Medication: Seretide 50 evohaler	0.7	0.9	2.5	0.9	1.6	1.1	-0.0	-1.5	-0.6	-0.4	-0.6	-0.5
Mean time to correctly identify matches	4.3	8.2	11.6	1.4	2.5	3.4	-2.9	-3.4	-2.9	-3.0	-2.8	-2.8
Heart disease (mother)	1.7	2.1	4.1	-0.7	-1.3	-1.6	1.5	2.0	1.4	1.4	1.5	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.8	6.4	-0.9	1.0	1.2	-2.5	-1.0	-1.7	-1.9	-2.0	-2.1
Whole body fat mass	0.6	2.4	4.5	-1.3	0.3	1.5	-2.0	-1.4	-1.5	-1.2	-1.8	-2.1
Leg fat mass (right)	1.1	4.4	7.1	-1.2	1.4	2.1	-2.4	-2.2	-2.2	-1.8	-2.5	-2.7
Arm predicted mass (right)	0.1	0.5	1.2	-1.0	-0.8	-0.7	0.3	0.3	0.7	1.1	0.6	0.4
Pulse rate, automated reading	2.5	8.1	12.9	-1.5	-3.6	-2.8	2.6	3.2	2.9	2.9	2.9	2.7
Alcohol intake frequency.	0.7	1.7	2.9	-0.4	-1.4	-1.2	1.1	1.5	1.5	1.1	1.7	1.6
Comparative height size at age 10	2.4	13.1	29.1	-2.0	-5.4	-4.2	2.2	3.9	3.8	3.7	3.4	2.8
Number of full sisters	3.0	3.6	5.2	-1.5	-2.3	-2.3	1.4	2.2	2.0	1.7	1.9	1.8
Suffer from ‘nerves’	0.3	0.4	2.7	1.6	0.4	0.6	-0.3	-0.8	-0.2	-0.4	0.1	0.2
Overall health rating	0.4	0.8	1.6	-0.9	1.3	0.8	-0.2	-1.1	-1.0	-0.9	-0.9	-0.7
Chest pain or discomfort	0.1	0.2	0.6	-0.1	0.8	0.3	-0.2	-0.4	-0.4	-0.4	-0.4	-0.5
Had major operations	2.8	3.3	5.4	0.7	1.6	1.9	-1.9	-2.3	-1.9	-1.9	-1.9	-2.0
Age at last live birth	1.2	1.8	2.7	1.2	-1.1	-1.0	1.6	1.5	1.3	1.2	1.4	1.6
Family relationship satisfaction	0.3	0.4	1.0	-0.4	-0.9	-0.7	-0.2	1.0	0.5	0.5	0.3	0.1
Leg pain on walking	0.2	0.2	0.7	-0.8	0.3	0.2	0.1	0.1	-0.6	-0.6	-0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	5.0	-2.2	-0.2	-0.1	-0.7	-0.4	-0.1	-0.0	-0.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.9	-0.1	0.0	0.0	-0.2	1.0	-0.1	-0.1	-0.0	-0.1
Illness, injury, bereavement, stress in last 2 years	0.0	0.1	0.2	0.4	0.4	0.2	0.3	0.0	-0.0	0.3	-0.1	-0.0
Medication: Aspirin	0.5	0.7	2.5	1.6	0.6	0.5	0.8	-1.6	0.0	0.4	0.1	0.3
Supplements: Vitamin C	0.8	0.9	1.9	-1.1	-1.4	-0.8	0.6	1.2	0.9	0.7	1.0	0.7
Knee pain experienced in last month	3.2	5.0	8.6	-2.1	1.0	1.5	-2.9	-1.2	-2.4	-2.2	-2.9	-2.9
Hypertension (Self-reported)	0.8	2.2	6.2	0.1	2.5	1.8	-0.2	-2.2	-1.4	-1.3	-1.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	0.1	0.3	0.2	-0.2	-0.2	-0.1	-0.1	-0.2	-0.2
Illnesses of father: Heart disease	0.1	0.1	0.2	0.5	-0.1	-0.4	0.4	0.5	0.3	0.2	0.3	0.4
Illnesses of siblings: Diabetes	0.5	0.6	1.7	-1.3	-0.4	0.4	-1.1	-0.5	-0.6	-0.9	-0.7	-0.9
Smoking status: Previous	0.7	1.1	5.2	2.3	0.8	0.6	0.5	-1.7	-0.1	-0.1	0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	4.5	9.3	16.4	-2.6	-4.1	-4.0	2.4	2.8	3.2	3.3	2.6	2.0
Whole body fat-free mass	0.6	3.1	6.2	-1.4	-2.5	-1.9	1.1	1.4	1.9	2.2	1.7	1.3
Leg fat-free mass (right)	0.8	4.0	9.1	-2.0	-3.0	-2.1	1.1	1.9	2.0	2.3	1.7	1.3
Arm fat percentage (left)	1.0	4.0	7.1	-1.2	0.7	2.0	-2.5	-1.5	-2.1	-2.0	-2.4	-2.7
Average weekly red wine intake	0.2	0.3	0.8	0.9	-0.4	-0.6	0.7	0.1	0.5	0.6	0.5	0.7
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.4	1.3	1.4	1.6	-0.9	-0.7	-1.3	-1.3	-1.0	-0.9
Mood swings	1.0	1.7	3.3	0.7	1.8	1.8	-1.1	-0.5	-1.5	-1.5	-1.3	-1.0
Loneliness, isolation	0.1	0.1	0.6	0.8	0.3	0.5	-0.0	-0.0	-0.1	-0.0	0.0	0.3
Long-standing illness, disability or infirmity	0.4	0.7	2.1	-1.3	-0.2	0.2	-0.6	-1.5	-0.4	-0.4	-0.8	-0.8
Ever had bowel cancer screening	1.0	1.2	3.6	1.9	-0.6	-0.2	1.2	1.0	0.7	0.5	1.2	1.5
Diabetes diagnosed by doctor	0.4	0.7	1.2	-0.5	-1.1	-0.6	1.0	0.2	0.9	1.1	0.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.9	0.2	0.1	-0.2	0.4	1.0	0.2	0.2	0.4	0.7
Friendships satisfaction	1.0	1.2	2.6	-0.7	-1.2	-1.3	0.8	1.6	1.0	0.9	1.0	1.0
Qualifications: nursing, teaching	1.0	1.5	2.8	-0.4	-1.7	-1.4	1.3	0.9	1.3	1.2	1.3	1.1
Commuting to job workplace: Walk	0.3	0.3	2.1	-1.4	-0.5	-0.4	0.2	0.5	0.2	0.0	0.3	0.2
Eye problems/disorders: Cataract	0.0	0.1	0.1	0.1	-0.2	0.3	-0.2	0.4	-0.1	-0.3	0.1	0.2
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	7.4	-0.5	-1.0	-1.9	2.1	2.3	2.1	1.9	2.5	2.7
Medication for cholesterol	0.3	0.5	3.9	2.0	-0.1	-0.2	-0.2	0.7	0.1	-0.1	0.1	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.5	0.2	0.0	0.3	-0.5	-0.1	0.2	-0.5	-0.2
Back pain experienced in last month	1.1	1.6	4.8	-2.2	-0.4	0.4	-1.2	0.4	-1.4	-1.5	-1.4	-1.5
Mineral and other dietary supplements	2.6	3.5	5.9	-1.3	-1.8	-2.4	1.0	1.7	2.2	2.4	1.7	1.6
Breast cancer (self-reported)	0.1	0.1	0.6	0.5	0.5	0.8	0.2	0.1	-0.3	-0.2	-0.1	0.1
Asthma (self-reported)	0.3	0.7	0.9	-0.2	0.9	0.8	-0.6	-0.9	-0.9	-0.9	-1.0	-0.9
Osteoporosis (self-reported)	0.2	0.2	0.6	-0.8	-0.6	-0.6	-0.1	0.3	0.2	0.2	-0.2	-0.4
Osteoarthritis (self-reported)	2.6	3.4	5.0	0.3	1.5	2.2	-2.1	-1.7	-2.1	-2.1	-2.0	-1.8
Medication: Aspirin	0.5	0.7	2.7	1.5	0.5	0.7	0.5	-1.7	-0.2	0.0	-0.1	-0.0
Medication: Gliclazide	2.1	2.4	5.5	-1.7	-2.3	-1.9	0.8	1.4	1.5	1.6	1.2	1.0
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	0.5	-0.7	-0.5	-0.1	1.0	0.6	0.5	0.4	0.3
Smoking status: Current	2.6	4.1	5.6	2.0	2.4	2.2	-1.9	-1.4	-2.2	-2.0	-2.1	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.0	-0.7	-0.5	-1.4	0.8	1.0	0.8	0.9	0.7	0.6
Whole body water mass	0.5	2.9	5.8	-1.4	-2.4	-1.8	1.0	1.4	1.8	2.1	1.6	1.2
Leg predicted mass (right)	0.8	4.0	9.2	-2.1	-3.0	-2.1	1.1	1.9	2.0	2.2	1.7	1.2
Arm fat mass (left)	0.6	2.5	4.5	-1.3	0.4	1.6	-2.1	-1.3	-1.6	-1.4	-1.9	-2.1
Number of self-reported non-cancer illnesses	1.4	2.5	3.3	-1.1	1.7	1.8	-1.4	-1.3	-1.7	-1.8	-1.7	-1.5
Average weekly champagne plus white wine intake	1.1	1.5	2.6	0.6	1.6	1.6	-1.0	-1.1	-1.4	-1.3	-1.2	-0.9
Miserableness	1.0	1.8	4.7	1.3	2.2	1.3	-0.7	-0.8	-1.4	-1.4	-1.3	-1.0
Guilty feelings	0.2	0.4	1.2	0.3	-0.2	0.4	-1.1	0.0	-0.7	-0.8	-0.6	-0.6
Wears glasses or contact lenses	0.8	1.0	2.0	1.4	0.8	1.4	-0.7	-1.1	-1.0	-0.9	-0.8	-0.6
Ever taken oral contraceptive pill	0.7	0.8	1.6	-0.6	-1.2	-1.2	0.7	-0.1	1.1	1.3	0.5	0.4
Hearing aid user	1.4	1.6	3.3	-0.2	-1.5	-0.9	1.2	1.8	1.0	0.8	1.6	1.6
Mother’s age at death	0.9	1.1	4.3	1.7	0.0	-0.1	0.9	-2.1	0.6	0.7	0.6	0.5
Financial situation satisfaction	1.3	1.7	2.4	0.2	-1.1	-1.5	1.3	1.5	1.4	1.5	1.2	1.1
Tinnitus: Yes, now most or all of the time	0.7	0.9	1.8	1.0	0.5	0.9	-0.9	-0.2	-1.2	-1.4	-0.9	-0.9
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.3	-0.6	-0.0	-0.1	-0.5	0.1	-0.2	0.1	0.2
Eye problems/disorders: Glaucoma	2.0	2.4	15.0	-3.9	-2.1	-1.1	-0.1	0.5	0.3	0.3	-0.1	-0.6
Medication: Blood pressure	0.9	1.7	3.9	-1.1	2.0	1.6	0.0	-1.6	-1.4	-1.2	-1.0	-0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.7	-0.8	-0.8	-0.4	0.3	0.3	0.3	0.2	0.2	0.2
Supplements: Fish oil (including cod liver oil)	1.9	2.5	4.6	2.2	1.8	1.8	-0.2	-2.1	-1.5	-1.6	-1.0	-1.0
High cholesterol (Self-reported)	0.1	0.2	1.1	-1.1	-0.3	0.0	-0.2	0.6	-0.1	-0.2	-0.2	-0.1
Medication: Bendroflumethiazide	1.0	1.6	3.4	0.3	1.9	1.8	-0.4	-1.4	-1.4	-1.3	-1.1	-0.8
Medication: Paracetamol	0.1	0.1	0.6	0.8	-0.1	0.3	-0.1	-0.5	-0.0	-0.0	0.1	0.2
Medication: Lisinopril	0.4	0.5	1.5	0.3	1.2	1.2	0.3	-0.6	-0.6	-0.8	-0.1	0.0
Medication: Atorvastatin	0.1	0.2	0.5	0.1	0.1	0.5	0.1	0.7	-0.4	-0.7	-0.1	-0.1
Illnesses of father: High blood pressure	0.1	0.1	0.5	-0.7	0.0	0.0	-0.2	-0.4	-0.3	-0.4	-0.2	-0.2
Alcohol drinker status: Never	0.1	0.1	0.3	-0.1	-0.1	0.3	0.5	0.4	0.2	0.1	0.5	0.6
Ever smoked	0.5	0.8	4.8	2.2	0.9	0.7	0.1	-1.0	-0.2	-0.3	-0.1	0.1
Basal metabolic rate	0.4	2.1	4.8	-1.5	-2.2	-1.5	0.7	1.0	1.5	1.8	1.2	0.9
Leg fat percentage (left)	3.9	14.2	18.7	-0.3	3.4	4.0	-3.9	-4.2	-4.0	-3.7	-4.3	-4.3
Arm fat-free mass (left)	0.1	0.5	1.2	-1.0	-0.9	-0.6	0.2	-0.2	0.7	1.1	0.5	0.3
Number of operations (self-reported)	3.1	4.7	7.5	0.5	2.7	2.4	-2.1	-0.8	-2.6	-2.6	-2.3	-2.0
Average weekly beer plus cider intake	0.7	1.1	1.5	-0.9	1.2	1.0	-0.9	-1.1	-1.0	-0.8	-1.1	-1.1
Irritability	1.3	2.1	6.7	2.6	1.4	1.6	-1.5	-0.8	-1.2	-1.5	-1.0	-0.8
Risk taking	2.8	4.1	7.4	-1.0	1.0	1.4	-2.5	-2.1	-2.2	-1.9	-2.6	-2.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.7	-0.6	-0.4	0.0	0.7	0.1	0.0	0.2	0.2
Fractured/broken bones in last 5 years	0.1	0.2	0.4	0.3	-0.4	-0.6	0.6	-0.4	0.5	0.5	0.2	0.1
Age started oral contraceptive pill	0.0	0.1	0.2	0.2	0.4	0.5	0.1	0.1	-0.2	-0.2	-0.0	0.1
Diastolic blood pressure, automated reading	0.3	0.9	5.2	0.0	1.3	0.7	0.1	-2.3	-0.3	0.0	-0.5	-0.6
Ever depressed for a whole week	0.7	0.9	1.5	0.7	-1.1	-1.2	0.8	0.5	1.0	1.0	1.0	0.9
Unable to work because of sickness or disability	1.1	1.4	1.8	-1.2	0.5	1.3	-1.2	-1.3	-1.2	-1.2	-1.3	-1.3
Commuting to job workplace: Cycle	3.6	4.3	8.2	-2.5	-2.8	-2.9	1.5	0.8	2.2	2.3	1.5	1.2
Myopia	0.7	1.0	2.3	1.5	0.4	1.2	-1.1	-0.1	-1.0	-1.5	-0.7	-0.6
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.3	-0.4	-2.5	-1.8	0.3	2.3	1.3	1.2	1.2	0.9
Cholesterol lowering medication	0.7	1.1	8.3	-2.9	-0.8	-0.4	-0.0	0.9	0.1	-0.0	0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	4.6	-0.0	1.6	1.6	-1.6	-2.1	-1.7	-1.5	-1.9	-1.9
Pain experienced in last month	0.2	0.4	1.4	0.9	1.1	0.4	0.3	-1.2	0.0	0.3	0.2	0.2
Supplements: Calcium	0.8	0.9	3.8	0.2	1.0	1.0	-0.3	-1.9	-0.7	-0.6	-0.8	-0.8
Basal cell carcinoma (self-reported)	0.4	0.5	1.8	1.3	0.7	0.5	0.3	-1.2	0.2	0.2	0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.7	1.4	0.8	0.9	-0.3	-1.6	-0.4	-0.5	-0.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.5	-0.5	0.6	1.0	-1.6	-0.9	-1.4	-1.4	-1.6	-1.5
Heart disease (siblings)	0.2	0.3	0.7	0.5	0.8	0.6	-0.4	-0.0	-0.8	-0.7	-0.5	-0.2
Alcohol drinker status: Previous	1.1	1.2	4.5	-0.2	-1.3	-1.0	0.7	2.1	0.8	0.5	1.1	1.2
Pack years of smoking	0.1	0.1	0.7	0.8	-0.2	-0.1	-0.3	0.1	-0.1	0.1	-0.1	-0.1
Impedance of whole body	1.4	7.1	13.8	-0.5	-3.7	-3.4	2.2	2.4	3.1	2.6	2.7	2.2
Leg fat mass (left)	1.1	4.4	7.0	-1.1	1.4	2.1	-2.3	-2.3	-2.1	-1.8	-2.5	-2.7
Arm predicted mass (left)	0.1	0.6	1.6	-0.9	-1.1	-0.7	0.4	0.0	0.9	1.3	0.8	0.5