Hub : Genes

ZFP41

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.0980	0.0430	3.8e-03	0.087	NA	0.056	NA	0.070	1.7e-05	NA	5.3e-04	NA	1.1e-04
2	GTEx	Skin Sun Exposed Lower leg	0.1710	0.0460	2.0e-08	0.145	NA	0.142	NA	0.150	4.4e-12	NA	8.5e-12	NA	2.0e-12
3	GTEx	Testis	0.1280	0.0470	1.0e-03	0.136	NA	0.093	NA	0.104	1.3e-06	NA	6.2e-05	NA	2.3e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.0890	0.0254	2.9e-08	0.077	0.036	0.044	0.039	0.062	3.5e-10	1.5e-05	2.0e-06	7.6e-06	1.9e-08
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0753	0.0331	2.4e-06	0.049	0.060	0.058	NA	0.068	3.3e-06	2.3e-07	4.1e-07	NA	4.2e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	0.9	2.1	-0.3	-0.9	1.4	-1.2	0.2
Bipolar Disorder or Schizophrenia	0.2	0.4	0.7	-0.4	-0.8	0.5	-0.7	0.6
Depressed Affect (Nagel 2018)	0.4	0.8	1.0	-0.9	-1.0	0.2	-1.0	1.0
Depression (Nagel 2018)	0.2	0.3	0.9	-0.6	-0.4	-0.9	0.2	0.4
Intelligence (Savage-Jansen 2018)	0.7	2.1	2.7	0.8	1.5	-1.6	1.6	-1.6
Neuroticism (Nagel 2018)	0.7	1.7	3.7	-1.6	-1.9	-0.7	-0.6	1.2
Schizophrenia (2018)	0.1	0.2	0.4	-0.3	-0.3	-0.6	0.2	0.6
Schizophrenia vs Biploar Disorder	1.3	1.8	3.8	-1.9	-1.2	-0.7	-0.0	1.8
Worry (Nagel 2018)	1.3	2.7	5.5	-2.2	-2.3	-0.8	-0.6	1.5
Alzheimer’s Disease (in mother)	2.0	2.3	3.6	-1.9	-1.7	1.2	-0.9	1.7
Alzheimer’s Disease (in father)	1.6	1.8	3.8	-0.4	-0.5	1.9	-1.5	1.6
Alzheimer’s Disease (including proxy)	1.9	2.7	5.1	-1.9	-1.7	1.0	-0.9	2.3
Crohns Disease (2017)	0.4	0.9	2.2	-0.5	-0.4	1.3	-1.5	0.5
Irritable Bowel Disease (IBD)	0.3	0.6	1.9	0.4	0.6	1.4	-0.9	0.0
Ulcerative Colitis (UC)	0.7	1.3	3.2	1.5	1.8	0.5	0.6	-0.9
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.6	1.1	1.4	-0.9	-0.9	1.1	-1.1	1.2
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.9	-0.6	0.5	-1.4	0.8	-0.8
Breast Cancer	0.2	0.5	1.1	1.1	0.8	0.8	-0.2	-0.2
Ovarian Cancer	1.2	1.5	2.0	-1.3	-1.1	1.0	-1.3	1.4
Prostate Cancer	0.1	0.1	0.2	-0.0	-0.1	0.4	0.1	-0.5
Age at First Birth	0.0	0.1	0.1	0.2	-0.1	0.2	-0.3	-0.3
Bipolar Disorder (2011)	0.1	0.1	0.6	0.0	0.0	0.0	0.0	0.8
Body Mass Index (BMI) (2010)	1.2	1.6	3.3	-0.5	-0.9	1.8	-1.8	0.8
Coronary Artery Disease (CAD)	2.5	3.0	5.1	-1.8	-2.3	1.0	-1.6	1.8
Crohns Disease (2012)	0.3	0.5	1.4	0.0	-0.5	0.9	-1.2	-0.0
Mean Putamen Volume	0.2	0.3	0.7	0.6	-0.1	0.8	-0.6	-0.1
Fasting Glucose	0.3	0.3	0.5	-0.7	-0.6	0.6	-0.6	0.3
HbA1C	0.4	0.4	1.2	-0.4	0.4	-0.8	1.1	0.3
HDL Cholesterol	0.9	1.5	3.4	-1.8	-1.3	-0.9	0.4	1.3
LDL Cholesterol	0.3	0.4	0.8	0.9	0.7	0.2	0.0	-0.8
Lupus	0.5	0.7	1.0	-0.5	-0.9	1.0	-1.0	0.8
Neuroticism (2016)	3.5	5.1	7.3	-2.7	-2.7	1.6	-2.1	2.0
Primary Biliary Cirrhosis	0.7	1.0	2.2	1.5	0.8	-0.3	0.6	-1.3
Rheumatoid Arthritis	4.6	6.3	12.9	3.6	3.2	-0.1	1.5	-2.5
Schizophrenia (2014)	0.4	0.9	1.4	-1.2	-1.1	-0.6	-0.3	1.2
Triglycerides	0.2	0.3	0.7	0.3	0.2	0.8	-0.8	-0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	-0.2	-0.3	0.8	-0.6	0.6
Ulcerative Colitis	0.7	1.0	2.5	1.1	0.8	1.6	-0.6	-0.6
Blood Eosinophil Count	0.5	3.8	5.9	2.0	1.6	2.4	-0.8	-2.4
Blood Platelet Count	0.1	1.3	3.1	-1.5	-1.1	-0.1	-0.1	1.8
Blood Red Count	1.1	10.3	18.3	-2.4	-2.2	3.5	-3.1	4.3
Blood White Count	0.5	3.5	7.7	-1.1	-1.5	2.8	-2.5	0.6
Heel T-Score	0.2	1.3	3.2	-0.7	-0.6	1.8	-1.5	0.6
BMI	1.1	6.6	18.3	-0.3	-1.3	4.3	-3.5	0.6
Height	4.9	94.2	125.4	8.5	8.5	-10.0	10.1	-11.2
Waist Hip Ratio (WHR)	0.1	0.4	0.9	-0.8	-1.0	-0.1	-0.5	0.3
Systolic Blood Pressure	0.3	1.7	3.3	-1.1	-1.3	1.0	-1.0	1.8
Smoking Status	1.9	4.6	6.9	-2.6	-1.9	1.6	-1.8	2.6
Allergy or Eczema	0.1	0.3	0.9	-0.0	0.4	1.0	-0.4	-0.1
Cardiovascular Disease	0.3	1.0	2.0	-0.7	-0.7	1.4	-1.4	0.4
Hypothyroidism (self reported)	0.3	0.6	0.8	0.9	0.9	-0.4	0.8	-0.8
Respiratory disease	0.6	1.3	3.9	0.2	0.2	2.0	-1.6	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.3	0.2	0.0	-0.1	-0.2	-0.6
Lung FEV1/FVC ratio	0.9	4.5	6.3	1.6	2.3	-1.7	2.5	-2.3
Lung FVC	0.1	0.3	1.0	-0.2	0.3	1.0	-0.5	0.7
Neuroticism	0.8	1.9	3.8	-2.0	-1.8	-0.8	-0.6	1.2
Chronotype (morning person)	0.1	0.3	0.8	0.1	0.0	-0.9	0.6	0.4
Hair Pigment	0.0	0.4	1.8	0.3	-0.2	-0.1	-0.3	-1.3
Tanning	0.3	3.1	7.5	-2.1	-1.1	1.1	-1.1	2.7
Hand grip strength (left)	0.2	0.5	1.0	0.1	0.3	-1.0	1.0	-0.5
Number of treatments/medications taken	0.5	1.0	1.9	-0.8	-0.8	1.0	-1.4	0.8
Average weekly spirits intake	0.8	1.0	1.4	1.2	1.1	-0.8	0.8	-1.0
Sensitivity / hurt feelings	0.6	1.0	3.0	0.4	0.6	-1.7	1.1	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.3	0.6	0.5	-0.4	0.3	-0.6
Hearing difficulty/problems: Yes	0.7	1.1	2.3	1.3	1.0	-0.4	0.5	-1.5
Relative age of first facial hair	0.6	1.2	2.4	-1.2	-1.4	-0.2	-0.5	1.6
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	-0.3	-0.3	-0.1	-0.4	-0.0
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.0	-1.4	-1.3	0.4	-1.1	1.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.4	-0.4	0.8	-0.7	-0.3
Systolic blood pressure, automated reading	0.8	2.3	4.1	-1.1	-1.2	1.5	-1.5	2.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	0.9	0.8	0.8	-0.9	0.9	-0.7
Angina	1.6	2.2	2.7	-1.6	-1.5	1.3	-1.4	1.4
Medication for hormone replacement therapy	0.7	0.8	1.7	-1.3	-1.1	-0.2	-0.8	0.6
Vitamin and mineral supplements	0.5	0.7	1.1	0.6	1.0	-0.6	0.9	-1.0
Supplements: Zinc	0.0	0.0	0.1	-0.0	-0.2	-0.0	-0.1	0.2
Medication: Co-codamol	0.1	0.2	0.3	0.5	0.2	0.6	-0.4	-0.1
Medication: Metformin	0.1	0.2	0.7	0.2	0.1	-0.2	-0.3	-0.8
Diabetes (father)	0.6	0.7	0.9	0.8	1.0	-0.8	0.8	-0.8
Diabetes (mother)	0.4	0.5	1.3	0.5	-0.2	1.1	-0.9	0.4
Severe depression (siblings)	0.8	0.9	1.8	0.5	0.8	-1.3	1.4	-0.0
Pack years adult smoking proportion	0.0	0.0	0.1	0.2	0.1	-0.2	0.3	-0.1
Impedance of leg (right)	0.2	1.2	3.2	0.0	0.4	-1.8	1.6	0.0
Leg fat-free mass (left)	1.4	7.6	14.8	3.1	2.6	-1.6	2.1	-3.9
Trunk fat percentage	0.5	2.1	5.1	2.2	1.7	0.7	-0.2	-1.5
Hand grip strength (right)	1.0	2.8	4.9	1.1	1.3	-2.1	2.2	-1.4
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.2	-0.0	0.5	-0.3	0.3
Current tobacco smoking	1.9	3.2	3.7	-1.7	-1.6	1.9	-1.9	1.8
Average weekly fortified wine intake	0.2	0.3	0.6	-0.4	-0.1	-0.7	0.8	0.2
Maternal smoking around birth	0.3	0.5	1.0	-1.0	-1.0	-0.7	-0.1	0.2
Fed-up feelings	0.4	0.7	1.5	0.9	0.9	-0.6	0.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	3.0	-0.6	-0.4	-1.7	0.9	0.2
Relative age voice broke	0.1	0.1	0.2	-0.5	-0.0	-0.3	0.3	0.2
Taking other prescription medications	0.1	0.2	0.5	-0.1	-0.3	0.7	-0.7	-0.2
Age when periods started (menarche)	2.4	5.7	11.6	1.2	2.0	-3.4	3.1	-1.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.3	-1.4	-1.5	0.6	-0.8	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	3.4	0.4	0.2	1.8	-1.1	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.5	0.2	-0.2	0.7	-0.5	0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.6	-0.1	0.2	0.1	0.1
Serious illness, injury or assault to yourself	0.1	0.2	0.6	0.0	-0.3	-0.4	-0.1	-0.8
High blood pressure	0.7	1.9	3.9	-0.9	-0.9	1.5	-2.0	1.4
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.1	0.2	0.5	-0.1	-0.4
Multivitamins +/- minerals	1.2	1.5	3.4	-1.0	-1.2	0.7	-1.0	1.8
Stomach or abdominal pain in last month	1.1	1.3	2.7	0.9	1.3	-1.2	1.6	-0.4
Supplements: Glucosamine	1.7	2.3	3.8	-1.3	-1.3	1.7	-2.0	1.2
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.1	-0.5	-0.7	2.0	-1.8	1.4
Medication: Atenolol	0.3	0.3	0.7	-0.4	-0.5	0.8	-0.8	0.1
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.4	0.2	0.6	-0.3	-0.5
Sitting height	1.5	10.4	13.8	2.4	2.6	-3.6	3.7	-3.6
Chronic bronchitis/emphysema (father)	1.0	1.2	1.8	-0.9	-1.3	1.0	-1.0	1.4
High blood pressure (mother)	0.5	0.7	1.3	1.1	1.1	0.9	-0.3	-0.0
Body mass index (BMI)	1.3	5.6	14.0	-0.3	-1.2	3.7	-3.3	1.3
Impedance of leg (left)	0.2	0.8	2.2	-0.3	0.2	-1.5	1.3	0.4
Leg predicted mass (left)	1.5	7.9	15.2	3.1	2.7	-1.6	2.2	-3.9
Trunk fat mass	0.6	2.7	5.8	2.4	1.7	0.4	0.0	-2.1
Waist circumference	0.3	1.2	1.9	1.4	0.6	1.4	-1.0	-0.8
Number of incorrect matches in round	5.8	9.6	13.0	-2.9	-3.3	2.9	-3.6	2.7
Past tobacco smoking	1.4	2.6	5.7	2.2	1.2	-0.4	0.9	-2.4
Alcohol usually taken with meals	0.0	0.0	0.1	0.3	0.2	-0.2	0.1	-0.2
Nervous feelings	0.3	0.6	2.2	0.2	-0.3	-1.5	0.9	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.2	1.1	0.6	-1.1	0.6	-1.0
Hearing difficulty/problems with background noise	3.6	5.7	10.8	2.5	2.1	-1.9	1.8	-3.3
Hair/balding pattern: Pattern 2	0.5	0.7	1.3	0.9	0.9	0.4	-0.1	-1.2
Had menopause	1.9	2.4	5.1	-1.2	-1.7	1.0	-2.3	1.2
Had other major operations	1.5	1.8	4.5	-0.8	-0.9	1.8	-2.1	-0.2
Forced vital capacity (FVC)	1.9	7.5	10.3	2.1	2.6	-2.5	3.2	-3.1
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.2	-0.8	-0.9	1.8	-1.5	1.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.9	0.8	0.4	-0.9	0.9	-0.6
Qualifications: None of the above	0.2	0.5	0.8	-0.4	-0.5	0.9	-0.8	0.8
Financial difficulties in last 2 years	0.3	0.3	0.9	-0.3	-0.3	0.8	-1.0	0.1
Mouth/teeth dental problems	0.8	1.3	2.7	0.4	0.6	-1.6	1.6	-0.8
Heart attack	1.7	2.1	4.7	-1.8	-1.4	0.5	-0.9	2.2
Allergy	0.2	0.6	1.8	-0.6	-0.3	-1.3	0.7	0.1
Pain all over the body in last month	1.9	2.1	3.0	-1.7	-1.7	0.9	-1.6	1.1
Diabetes (self-reported)	0.4	0.6	0.8	0.8	0.8	-0.6	0.7	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	0.5	0.8	0.6	0.1	0.1
Medication: Ramipril	0.8	1.0	2.8	0.2	-0.3	1.7	-1.4	-0.5
Medication: Simvastatin	0.4	0.6	1.4	-0.3	-0.2	1.2	-1.1	0.1
Fluid intelligence score	0.2	0.5	0.9	-0.2	0.7	-0.8	0.6	-0.9
Illnesses of siblings	1.7	2.3	3.7	1.4	1.6	-1.2	1.9	-1.3
Neuroticism score	1.0	2.1	3.3	-1.8	-1.8	-0.3	-0.9	1.8
Weight	0.5	2.7	5.4	2.3	1.6	0.2	0.2	-2.3
Impedance of arm (right)	4.2	19.6	27.7	3.4	4.0	-5.3	5.2	-3.8
Arm fat percentage (right)	0.4	1.7	3.4	1.5	0.7	1.9	-1.4	-0.7
Trunk fat-free mass	0.7	3.9	9.2	1.8	1.2	-1.7	1.7	-3.0
Hip circumference	1.3	5.8	11.4	3.4	2.7	-0.2	1.2	-2.9
Time employed in main current job	0.9	1.1	3.3	-0.5	-0.4	-1.8	1.2	-0.5
Alcohol intake versus 10 years previously	0.9	1.4	3.0	-0.3	-0.6	1.7	-1.7	0.7
Father’s age at death	0.9	1.2	2.7	-1.7	-1.0	0.2	-0.4	1.4
Worrier / anxious feelings	0.7	1.3	2.5	-1.4	-1.6	-0.1	-0.9	1.0
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.1	5.7	1.7	1.6	-2.2	2.2	-2.4
Falls in the last year	0.7	0.9	2.7	1.6	1.1	0.5	0.2	-0.6
Hair/balding pattern: Pattern 3	0.3	0.5	0.8	-0.3	-0.9	0.9	-0.9	-0.1
Number of live births	5.6	7.9	8.8	2.9	2.5	-2.8	2.9	-3.0
Forced expiratory volume in 1-second (FEV1)	2.8	9.5	13.4	2.4	2.9	-2.8	3.7	-3.4
Pulse rate	1.7	2.9	5.9	0.8	0.9	-1.9	1.9	-2.4
Happiness	1.0	1.2	1.7	1.3	1.3	-0.8	0.9	-1.1
Noisy workplace	1.0	1.2	1.9	-1.1	-1.1	1.2	-1.4	0.5
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.0	0.0	-0.2	0.2	0.1	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	0.7	0.5	-0.8	0.5	-1.0
Mouth/teeth dental problems: Dentures	0.7	1.2	3.4	0.1	0.1	1.8	-1.4	0.7
Asthma	0.3	0.7	1.8	0.8	0.6	1.3	-0.8	0.0
Medication: Ibuprofen (e.g. Nurofen)	4.6	5.9	7.2	-2.3	-2.6	2.3	-2.2	2.7
Medication: Cholesterol lowering	1.4	2.1	3.3	-1.3	-1.2	1.6	-1.8	1.2
Depression (self-reported)	0.6	0.7	2.0	-1.4	-0.9	-0.3	-0.3	0.6
Medication: Lansoprazole	0.5	0.6	1.4	-0.4	-0.8	0.8	-1.2	0.3
Prospective memory result	1.2	1.5	2.6	-1.2	-1.6	0.5	-0.8	1.5
Lung cancer (father)	1.0	1.2	3.0	-0.4	-0.4	1.7	-1.6	0.4
Illnesses of mother	0.5	0.6	1.6	-1.3	-1.0	-0.7	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	4.5	14.5	22.2	3.1	3.8	-3.8	4.7	-3.3
Pulse wave Arterial Stiffness index	9.4	11.0	14.6	-2.8	-3.7	3.0	-3.8	3.1
Impedance of arm (left)	3.7	17.0	21.9	3.4	3.9	-4.7	4.6	-3.8
Arm fat mass (right)	0.4	1.5	2.4	1.6	0.8	1.5	-1.0	-1.0
Trunk predicted mass	0.7	3.9	9.0	1.7	1.2	-1.7	1.7	-3.0
Standing height	4.7	46.6	62.2	5.5	5.8	-7.3	7.3	-7.9
Length of working week for main job	0.9	1.0	1.8	-0.4	-0.6	1.4	-1.3	1.1
Exposure to tobacco smoke at home	0.5	0.6	1.5	0.4	-0.4	1.2	-0.8	0.6
Breastfed as a baby	2.9	3.6	6.4	2.5	2.3	-0.9	1.0	-2.1
Tense / ‘highly strung’	2.5	4.2	5.9	-2.2	-2.4	1.2	-1.9	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.9	-0.7	-1.2	1.3	-1.4	0.4
Hair/balding pattern: Pattern 4	0.4	1.0	2.4	-0.0	0.5	-1.5	1.6	-0.2
Birth weight of first child	0.5	0.9	1.6	1.3	0.9	1.0	-0.3	-1.0
Peak expiratory flow (PEF)	3.4	8.0	10.6	2.2	2.5	-2.9	3.3	-3.1
Pulse wave reflection index	11.6	14.3	20.1	-3.3	-3.6	4.1	-4.5	3.3
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	0.3	-0.1	0.1	-0.2	0.2
Loud music exposure frequency	0.1	0.1	0.3	-0.5	-0.1	-0.0	-0.2	0.5
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	3.2	1.0	1.1	-1.4	1.4	-1.8
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	4.5	-1.5	-2.0	1.6	-2.1	1.7
Blood clot in the leg (DVT)	0.3	0.3	1.2	-0.2	-0.3	1.1	-0.6	-0.0
Medication: Paracetamol	0.2	0.4	0.9	-0.7	-0.6	-0.4	-0.2	0.9
Headache pain in last month	0.7	1.2	3.2	-0.5	-0.2	-1.8	1.3	0.9
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	3.0	1.3	1.4	-1.3	1.7	-1.2
Glaucoma (self-reported)	5.6	6.5	12.3	3.5	2.7	-0.0	1.4	-3.3
Gout (self-reported)	2.0	2.8	4.7	-1.1	-1.4	2.0	-2.2	1.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	-0.1	-0.4	0.5	-0.6	0.1
Medication: Amlodipine	0.2	0.3	0.4	0.5	0.6	-0.5	0.6	-0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.3	0.4	-0.1	-0.1	0.4
Birth weight	0.6	1.2	2.6	-0.7	-1.2	1.2	-1.6	-0.1
Chronic bronchitis/emphysema (mother)	1.5	1.7	2.4	-1.3	-1.1	1.2	-1.6	1.4
High blood pressure (siblings)	1.1	1.5	2.3	-1.4	-0.9	0.9	-1.5	1.3
Forced vital capacity (FVC), Best measure	2.9	10.6	16.2	2.7	3.4	-3.1	4.0	-2.9
Body fat percentage	0.5	1.8	4.1	1.4	0.7	2.0	-1.5	-0.4
Leg fat percentage (right)	1.7	6.2	15.1	-0.2	-1.1	3.9	-3.5	1.5
Arm fat-free mass (right)	0.2	1.2	4.0	1.2	0.7	-0.3	0.5	-2.0
Exposure to tobacco smoke outside home	2.4	3.1	4.2	-2.0	-1.9	1.6	-1.4	1.9
Comparative body size at age 10	1.5	4.0	7.2	-1.0	-2.0	2.4	-2.7	1.5
Number of full brothers	0.3	0.4	1.2	0.1	-0.3	1.1	-0.9	0.1
Worry too long after embarrassment	1.1	1.8	5.1	0.4	0.2	-2.3	1.9	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.8	-0.5	0.2	-0.2	1.0
Wheeze or whistling in the chest in last year	0.5	0.9	2.3	0.0	0.2	1.5	-0.7	1.4
Number of children fathered	2.2	2.5	4.3	1.7	1.3	2.1	-1.4	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.1	-0.8	-0.7	1.0	-1.0	1.1
Age at first live birth	0.4	0.7	1.4	0.3	0.4	-1.2	1.1	-0.8
Pulse wave peak to peak time	11.5	13.5	17.6	3.1	4.1	-3.4	4.2	-3.5
Health satisfaction	0.1	0.1	0.3	0.1	-0.2	0.6	-0.3	0.4
Shortness of breath walking on level ground	0.4	0.4	1.5	1.2	0.7	0.1	-0.0	-0.3
Qualifications: College or University degree	0.0	0.1	0.2	0.3	-0.1	0.4	0.1	-0.4
Eye problems/disorders: None of the above	1.6	1.9	4.3	-1.4	-0.4	1.1	-1.3	2.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-0.8	-0.7	0.8	-1.0	0.7
Emphysema/chronic bronchitis	1.1	1.3	3.8	1.9	1.5	-0.1	0.6	-0.3
Medication for pain relief, constipation, heartburn	2.9	5.0	8.3	2.2	2.3	-1.7	1.9	-2.9
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.2	-0.3	-0.2	-0.2	-0.0
Medication: Blood pressure	0.5	0.9	1.5	-0.8	-0.9	0.9	-1.2	0.9
Angina (self-reported)	1.8	2.4	2.9	-1.7	-1.6	1.4	-1.5	1.5
Migraine (self-reported)	1.3	1.6	4.2	0.5	0.5	-2.0	1.2	-1.3
Medication: Ibuprofen	4.1	4.9	6.0	-1.9	-2.4	2.3	-2.1	2.4
Medication: Allopurinol	1.0	1.4	4.1	0.0	-0.5	2.0	-1.6	0.0
Medication: Omeprazole	0.8	0.9	2.9	0.0	-0.1	1.7	-1.3	-0.1
Medication: Seretide 50 evohaler	0.3	0.4	0.9	0.3	0.3	0.9	-0.6	0.7
Mean time to correctly identify matches	2.5	4.7	7.2	-1.5	-1.7	2.4	-2.7	2.3
Heart disease (mother)	2.4	2.9	4.0	2.0	1.9	-1.3	1.7	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.2	-0.4	-1.0	1.4	-1.5	0.7
Whole body fat mass	0.4	1.6	2.4	1.5	0.7	1.6	-1.1	-1.1
Leg fat mass (right)	0.5	2.1	5.8	0.9	0.1	2.4	-1.9	-0.3
Arm predicted mass (right)	0.2	1.0	3.5	1.0	0.4	-0.1	0.3	-1.9
Pulse rate, automated reading	2.0	6.5	9.6	2.0	2.1	-2.8	2.6	-3.1
Alcohol intake frequency.	0.7	1.7	4.6	0.8	0.9	-2.1	1.5	-0.3
Comparative height size at age 10	2.5	13.8	21.6	3.0	3.3	-3.9	3.5	-4.7
Number of full sisters	3.1	3.7	4.7	1.7	1.9	-2.2	1.8	-2.0
Suffer from ‘nerves’	0.7	1.2	2.0	-1.3	-1.4	-0.2	-0.2	1.4
Overall health rating	0.4	0.8	1.1	0.1	-0.8	1.1	-1.1	0.9
Chest pain or discomfort	0.5	0.7	2.2	1.0	1.5	0.4	0.2	0.3
Had major operations	1.6	1.8	3.1	-1.1	-1.2	1.8	-1.6	1.0
Age at last live birth	0.5	0.7	1.6	-0.2	0.2	-1.3	1.1	-0.6
Family relationship satisfaction	0.6	0.7	1.3	0.9	0.5	-0.6	0.9	-1.1
Leg pain on walking	0.2	0.2	0.3	0.5	0.5	0.5	-0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.3	1.1	1.0	0.2	-0.1	-0.8
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.3	0.3	0.1	-0.1	-0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	0.3	0.7	0.3	0.3	-0.4
Medication: Aspirin	0.7	0.9	2.2	-1.1	-0.8	0.2	-0.6	1.5
Supplements: Vitamin C	1.1	1.3	2.4	1.0	1.0	-1.1	1.0	-1.6
Knee pain experienced in last month	1.5	2.4	6.3	0.8	0.0	2.5	-1.8	-1.2
Hypertension (Self-reported)	0.7	2.1	3.9	-1.0	-1.0	1.5	-2.0	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	0.2	0.2	0.3	0.2	0.1
Illnesses of father: Heart disease	0.2	0.3	0.8	0.5	0.9	-0.3	0.6	-0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.5	0.1	-0.2	0.4	-0.7	-0.6
Smoking status: Previous	1.0	1.5	3.5	-1.9	-0.9	-0.2	-0.3	1.8
Forced expiratory volume in 1-second (FEV1), predicted	8.0	16.6	23.4	4.2	4.2	-2.9	4.0	-4.8
Whole body fat-free mass	0.8	4.9	10.6	2.3	1.8	-1.5	1.8	-3.2
Leg fat-free mass (right)	1.5	7.8	15.0	3.0	2.6	-1.7	2.3	-3.9
Arm fat percentage (left)	0.5	2.0	4.0	1.6	0.7	2.0	-1.5	-0.7
Average weekly red wine intake	0.4	0.6	1.2	-1.1	-0.9	-0.3	-0.5	0.9
Handedness (chirality/laterality): Left-handed	1.4	1.7	2.6	-1.3	-1.1	1.4	-1.6	1.0
Mood swings	2.1	3.8	5.1	-1.7	-2.3	1.4	-2.2	2.1
Loneliness, isolation	0.4	0.6	1.1	-1.1	-1.1	0.1	-0.4	0.6
Long-standing illness, disability or infirmity	0.2	0.2	0.8	-0.3	-0.9	0.1	-0.5	0.3
Ever had bowel cancer screening	0.6	0.8	1.6	-1.3	-0.8	-1.1	-0.0	0.6
Diabetes diagnosed by doctor	0.3	0.6	0.8	0.8	0.9	-0.7	0.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.9	-1.4	-1.2	0.0	-0.4	0.2
Friendships satisfaction	0.6	0.8	1.3	0.4	0.3	-1.0	1.1	-1.1
Qualifications: nursing, teaching	1.1	1.7	2.4	1.0	1.3	-1.4	1.6	-1.1
Commuting to job workplace: Walk	0.5	0.5	1.0	1.0	0.6	-0.3	0.7	-0.9
Eye problems/disorders: Cataract	1.3	1.5	3.9	-1.5	-2.0	-0.2	-0.4	1.0
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.2	-0.9	-0.7	-2.0	1.2	0.1
Medication for cholesterol	0.2	0.4	0.8	-0.9	-0.5	-0.3	0.7	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.9	-1.3	-1.4	0.5	-0.7	0.8
Back pain experienced in last month	1.1	1.6	4.1	2.0	1.1	1.1	-0.6	-1.2
Mineral and other dietary supplements	1.6	2.1	3.9	0.8	1.1	-2.0	1.9	-1.2
Breast cancer (self-reported)	0.5	0.6	1.1	-0.8	-1.1	0.3	-0.5	1.0
Asthma (self-reported)	0.2	0.5	0.9	0.8	0.7	1.0	-0.5	-0.1
Osteoporosis (self-reported)	0.7	0.9	2.4	1.6	1.1	-0.2	0.5	-0.6
Osteoarthritis (self-reported)	4.4	5.7	7.4	-2.3	-2.7	1.8	-2.6	2.4
Medication: Aspirin	0.5	0.7	1.6	-0.9	-0.8	0.3	-0.7	1.3
Medication: Gliclazide	3.2	3.6	8.0	1.9	1.7	-1.4	1.2	-2.8
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	-0.1	-0.4	-0.9	0.6	-0.3
Smoking status: Current	2.4	3.8	6.0	-1.5	-1.5	2.5	-2.3	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	3.0	1.6	1.7	-0.6	1.6	-1.7
Whole body water mass	0.8	4.5	10.2	2.2	1.7	-1.4	1.7	-3.2
Leg predicted mass (right)	1.5	7.9	15.4	3.0	2.7	-1.7	2.3	-3.9
Arm fat mass (left)	0.4	1.6	2.9	1.4	0.6	1.7	-1.3	-1.0
Number of self-reported non-cancer illnesses	0.7	1.2	2.9	-0.2	-0.4	1.6	-1.7	0.6
Average weekly champagne plus white wine intake	1.8	2.4	3.9	-1.3	-1.6	1.6	-2.0	1.1
Miserableness	0.7	1.2	2.5	-0.1	-0.3	1.6	-1.3	1.3
Guilty feelings	0.6	0.9	2.1	-0.6	-1.5	0.3	-1.2	0.7
Wears glasses or contact lenses	2.3	2.7	4.8	-1.6	-2.2	0.8	-1.9	1.3
Ever taken oral contraceptive pill	1.1	1.2	2.0	0.7	1.1	-0.9	1.1	-1.4
Hearing aid user	0.6	0.7	1.8	-0.4	-0.1	-1.4	0.9	-0.7
Mother’s age at death	0.3	0.4	0.8	0.0	0.6	-0.7	0.9	0.7
Financial situation satisfaction	1.6	1.9	3.3	1.4	1.5	-1.2	1.8	-0.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.2	-0.6	-1.0	0.9	-1.5	0.4
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.3	-0.0	-0.5	0.2	0.4
Eye problems/disorders: Glaucoma	5.9	7.0	13.7	3.7	2.8	-0.3	1.4	-3.4
Medication: Blood pressure	0.7	1.4	3.2	-0.1	-0.5	1.6	-1.8	0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	0.9	0.4	-0.5	0.3	-0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.0	-0.2	-0.5	1.4	-0.9	1.1
High cholesterol (Self-reported)	0.0	0.1	0.2	0.5	0.1	-0.1	-0.1	-0.4
Medication: Bendroflumethiazide	0.9	1.3	2.1	-1.1	-0.8	1.3	-1.4	1.0
Medication: Paracetamol	0.1	0.1	0.3	-0.2	-0.4	-0.1	-0.3	0.5
Medication: Lisinopril	0.4	0.5	2.2	-0.2	-0.2	0.3	-0.4	1.5
Medication: Atorvastatin	0.1	0.1	0.2	-0.0	-0.4	-0.0	-0.4	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.5	0.2	0.7	0.2	-0.0	-0.1
Alcohol drinker status: Never	0.2	0.2	0.4	0.6	0.3	-0.5	0.2	0.6
Ever smoked	0.8	1.5	3.7	-1.7	-0.8	0.0	-0.4	1.9
Basal metabolic rate	0.8	4.2	9.2	2.3	1.8	-1.1	1.5	-3.0
Leg fat percentage (left)	1.9	7.0	17.0	-0.3	-1.2	4.1	-3.7	1.7
Arm fat-free mass (left)	0.2	1.1	3.3	1.3	0.7	-0.1	0.3	-1.8
Number of operations (self-reported)	3.2	4.8	8.2	-1.7	-1.8	2.7	-2.9	1.5
Average weekly beer plus cider intake	0.8	1.2	1.5	-1.1	-0.8	1.2	-1.1	1.1
Irritability	2.9	4.8	7.0	-2.6	-2.6	0.9	-2.1	2.3
Risk taking	1.4	2.0	5.7	-0.1	-0.4	2.4	-2.1	-0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.3	-0.2	-0.3	-0.3	-0.5
Fractured/broken bones in last 5 years	1.1	1.4	2.9	1.7	1.3	-0.4	0.7	-1.3
Age started oral contraceptive pill	0.0	0.0	0.1	0.2	0.1	0.1	-0.3	0.3
Diastolic blood pressure, automated reading	0.1	0.4	0.9	0.9	0.6	0.7	-0.3	0.2
Ever depressed for a whole week	0.5	0.6	1.3	0.2	0.8	-1.1	1.1	-0.1
Unable to work because of sickness or disability	0.7	0.8	2.5	-0.1	-0.5	1.1	-1.6	0.3
Commuting to job workplace: Cycle	5.3	6.4	7.8	2.5	2.8	-2.0	2.5	-2.8
Myopia	0.5	0.7	1.6	-0.7	-0.6	0.3	-0.9	1.3
Vascular/heart problems diagnosed by doctor	0.9	2.5	4.1	1.3	1.3	-1.5	2.0	-1.7
Cholesterol lowering medication	1.7	2.5	5.6	2.4	1.7	-0.3	0.5	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.8	-0.7	-0.8	2.0	-1.7	0.7
Pain experienced in last month	0.6	1.0	2.1	-1.4	-0.9	0.3	-0.6	1.4
Supplements: Calcium	0.4	0.5	0.8	0.1	-0.8	0.7	-0.9	0.6
Basal cell carcinoma (self-reported)	0.8	0.9	1.5	-1.2	-1.1	-0.1	-0.6	1.2
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.1	-1.3	-1.0	0.2	-0.5	1.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.6	-0.3	-0.3	1.2	-0.8	-0.2
Heart disease (siblings)	1.3	1.5	2.1	-1.3	-1.3	0.7	-1.4	1.2
Alcohol drinker status: Previous	0.3	0.3	1.3	0.3	0.1	-1.1	0.1	-0.5
Pack years of smoking	0.0	0.0	0.0	0.2	0.1	0.0	-0.0	0.2
Impedance of whole body	1.7	8.5	12.9	2.2	2.7	-3.6	3.6	-2.2
Leg fat mass (left)	0.5	2.0	5.7	1.0	0.2	2.4	-1.8	-0.3
Arm predicted mass (left)	0.2	1.0	2.9	1.2	0.6	-0.3	0.5	-1.7