Hub : Genes

BOP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0960	0.0460	7.5e-03	0.060	NA	0.059	NA	0.065	3.3e-04	NA	3.5e-04	NA	1.8e-04
2	GTEx	Thyroid	0.1890	0.0500	8.7e-09	0.095	NA	0.153	NA	0.145	9.4e-08	NA	8.8e-12	NA	3.3e-11
3	YFS	Blood	0.0321	0.0128	1.6e-04	0.003	0.015	0.013	0.016	0.009	2.5e-02	7.6e-06	3.4e-05	5.2e-06	4.7e-04
4	TCGA	Skin Cutaneous Melanoma	0.1270	0.1090	7.3e-03	0.046	-0.011	0.005	NA	-0.010	2.3e-02	8.5e-01	2.3e-01	NA	7.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.7	2.7	0.2	1.7	0.1	-0.4
Bipolar Disorder or Schizophrenia	0.4	1.1	2.9	-1.0	0.2	-1.7	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.5	0.1	-0.0	-0.7	-0.4
Depression (Nagel 2018)	0.8	1.3	2.4	1.5	1.1	-0.1	-1.2
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.8	1.3	0.7	1.9	0.3
Neuroticism (Nagel 2018)	0.5	1.1	1.6	0.9	1.1	-0.8	-1.3
Schizophrenia (2018)	1.2	2.5	5.4	-1.5	-1.1	-2.3	1.1
Schizophrenia vs Biploar Disorder	0.0	0.1	0.3	0.0	0.0	0.0	0.5
Worry (Nagel 2018)	0.6	1.3	2.2	0.9	1.5	-0.4	-1.5
Alzheimer’s Disease (in mother)	0.4	0.5	1.6	-1.3	-0.2	-0.4	0.2
Alzheimer’s Disease (in father)	0.5	0.5	1.6	1.3	0.4	0.5	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	-0.1	1.0	0.2	-0.4
Crohns Disease (2017)	3.3	7.1	14.8	2.2	3.8	1.5	-2.6
Irritable Bowel Disease (IBD)	3.5	8.4	17.4	2.2	4.2	1.2	-3.1
Ulcerative Colitis (UC)	1.8	3.4	7.2	1.2	2.7	0.7	-2.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.2	0.4	1.2	-0.3	-0.5	-1.1	-0.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	4.7	1.1	-0.2	2.2	1.0
Breast Cancer	0.0	0.1	0.3	0.1	-0.2	0.5	0.1
Ovarian Cancer	0.5	0.6	1.2	-0.5	-0.6	-0.8	1.1
Prostate Cancer	0.2	0.3	0.6	0.8	-0.0	0.6	-0.3
Age at First Birth	1.0	1.5	2.8	1.7	0.7	1.7	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	-0.8	-0.9	-1.3	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	4.1	6.6	15.2	3.9	0.0	3.3	0.0
Mean Putamen Volume	0.4	0.4	1.2	-0.2	1.1	0.5	-0.3
Fasting Glucose	0.2	0.2	0.8	-0.2	0.9	0.4	-0.1
HbA1C	1.5	1.6	3.2	1.8	1.3	1.2	0.0
HDL Cholesterol	1.2	1.9	2.8	-1.6	-1.7	-1.5	0.0
LDL Cholesterol	0.6	0.9	3.0	-1.7	-0.3	-0.8	0.0
Lupus	1.5	2.3	4.4	2.0	0.7	2.1	-0.6
Neuroticism (2016)	0.6	0.9	2.1	0.1	1.5	-0.0	-1.1
Primary Biliary Cirrhosis	2.2	3.2	4.8	1.5	2.1	1.1	-2.2
Rheumatoid Arthritis	2.1	2.9	4.6	2.2	1.7	-0.3	-2.0
Schizophrenia (2014)	0.5	1.2	2.4	0.6	1.2	-1.6	-0.7
Triglycerides	0.0	0.1	0.1	0.2	-0.3	-0.4	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.2	0.3	1.0	0.0	0.0	1.0	0.0
Blood Eosinophil Count	1.7	13.2	21.3	3.4	4.6	1.6	-4.2
Blood Platelet Count	2.4	28.3	55.1	-7.4	-4.0	-5.3	3.6
Blood Red Count	0.4	3.9	10.5	2.0	0.5	3.2	-1.1
Blood White Count	0.1	1.1	1.7	-1.3	0.1	-1.3	-0.9
Heel T-Score	2.1	16.7	22.1	2.7	4.7	4.7	-3.9
BMI	0.5	3.1	7.7	-1.6	-2.8	-1.2	0.7
Height	4.4	84.0	144.0	12.0	8.1	8.6	-7.2
Waist Hip Ratio (WHR)	2.7	12.4	16.6	4.1	4.1	2.5	-3.1
Systolic Blood Pressure	0.3	1.4	2.5	-0.9	-1.5	1.6	0.6
Smoking Status	1.0	2.4	4.0	2.0	2.0	-0.5	-1.3
Allergy or Eczema	0.1	0.3	0.6	0.6	0.2	-0.2	0.7
Cardiovascular Disease	0.6	2.0	6.1	-0.8	-0.9	2.5	0.5
Hypothyroidism (self reported)	0.1	0.2	0.7	-0.1	0.8	-0.4	-0.1
Respiratory disease	0.4	0.9	2.6	1.6	0.8	-0.0	-0.5
Type 2 Diabetes (T2D) (2018)	4.1	7.8	11.8	2.1	3.0	3.4	-2.4
Lung FEV1/FVC ratio	0.6	3.0	8.1	-2.9	-0.5	-1.4	1.3
Lung FVC	8.7	44.4	65.0	-5.0	-8.1	-7.7	5.3
Neuroticism	1.4	3.3	5.8	1.4	2.4	0.2	-2.3
Chronotype (morning person)	0.7	1.6	3.6	0.4	1.6	0.3	-1.9
Hair Pigment	0.1	1.6	2.5	1.6	1.2	0.6	-1.4
Tanning	0.2	2.3	2.7	1.6	1.3	1.5	-1.6
Hand grip strength (left)	0.6	1.5	3.2	1.8	1.4	-0.3	-1.0
Number of treatments/medications taken	0.2	0.3	1.1	-0.2	0.1	1.1	-0.2
Average weekly spirits intake	0.5	0.7	1.0	0.1	0.9	-0.9	-1.0
Sensitivity / hurt feelings	0.5	0.8	1.3	0.4	1.1	-0.7	-1.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	0.7	0.8	-0.3	-0.9
Hearing difficulty/problems: Yes	0.6	1.0	1.6	-0.4	-1.2	-1.1	1.0
Relative age of first facial hair	0.7	1.3	4.1	2.0	-0.4	1.0	0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	-0.5	-0.3	-0.9	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.3	-0.2	0.4	-0.4
Ever had hysterectomy (womb removed)	2.7	3.0	5.5	2.4	1.7	1.3	-1.4
Systolic blood pressure, automated reading	0.4	1.0	3.1	0.0	-0.5	1.8	-0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	0.9	-0.9	-0.4	0.8	0.9
Angina	0.2	0.2	0.7	-0.8	0.2	0.1	-0.5
Medication for hormone replacement therapy	1.0	1.1	2.7	-1.7	-1.1	0.2	0.7
Vitamin and mineral supplements	0.0	0.0	0.1	-0.0	-0.1	-0.2	-0.2
Supplements: Zinc	0.1	0.1	0.3	0.3	-0.2	-0.6	0.3
Medication: Co-codamol	0.6	0.7	2.2	-0.4	-0.5	-1.5	-0.6
Medication: Metformin	3.4	4.8	6.2	1.6	2.5	2.5	-2.0
Diabetes (father)	2.0	2.4	3.0	1.5	1.6	1.7	-1.4
Diabetes (mother)	0.1	0.2	0.6	0.3	-0.2	0.8	0.0
Severe depression (siblings)	1.9	2.2	2.7	-1.5	-1.5	-1.2	1.6
Pack years adult smoking proportion	0.7	1.1	2.7	0.8	0.4	0.9	-1.6
Impedance of leg (right)	3.0	14.5	25.4	3.8	5.0	2.8	-3.3
Leg fat-free mass (left)	0.2	1.2	3.0	1.7	-0.4	1.2	-0.5
Trunk fat percentage	1.8	7.1	10.4	3.2	2.2	2.7	-2.4
Hand grip strength (right)	0.2	0.6	1.1	1.1	-0.2	-1.1	0.5
Townsend deprivation index at recruitment	0.7	1.0	2.5	-1.6	-0.2	-0.8	1.0
Current tobacco smoking	0.7	1.1	1.5	1.2	1.2	0.7	-0.9
Average weekly fortified wine intake	1.2	1.4	3.8	2.0	1.0	0.8	-0.4
Maternal smoking around birth	8.8	12.8	20.0	4.5	3.2	2.3	-3.9
Fed-up feelings	0.5	1.0	2.5	-0.9	-0.6	-1.6	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.5	1.6	1.2	-0.6	-1.0
Relative age voice broke	0.5	0.8	2.9	1.7	-0.6	-0.1	0.3
Taking other prescription medications	0.3	0.4	1.2	-0.1	1.1	0.6	-0.3
Age when periods started (menarche)	0.7	1.7	4.2	1.3	1.0	2.0	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.4	-0.6	-0.6	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	3.8	8.5	12.0	2.8	3.5	1.7	-3.4
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	3.7	1.9	1.7	0.1	-1.6
Qualifications: CSEs or equivalent	2.2	2.8	7.3	-1.5	-1.0	-2.7	0.8
Serious illness, injury or assault to yourself	1.7	2.0	2.8	-0.9	-1.5	-1.5	1.7
High blood pressure	0.4	1.2	3.1	-0.8	-0.9	1.8	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.7	0.5	-0.2	0.7
Multivitamins +/- minerals	0.5	0.7	1.2	0.6	1.1	1.0	-0.4
Stomach or abdominal pain in last month	0.6	0.8	1.6	-0.9	-0.6	-0.5	1.3
Supplements: Glucosamine	0.7	0.9	1.5	1.2	0.7	1.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	-0.1	-0.5	1.1	0.6
Medication: Atenolol	0.3	0.4	1.2	-1.1	-0.6	-0.1	0.3
Medication: Levothyroxine sodium	0.1	0.2	0.5	-0.6	-0.2	-0.1	0.7
Sitting height	5.8	41.1	54.5	7.4	6.6	5.9	-5.6
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.5	-0.4	0.8	-0.2
High blood pressure (mother)	3.1	4.3	5.6	-2.4	-1.9	-1.6	2.4
Body mass index (BMI)	0.4	1.6	4.4	-1.0	-2.1	-1.0	0.5
Impedance of leg (left)	2.5	12.3	22.8	3.4	4.8	2.4	-2.9
Leg predicted mass (left)	0.2	1.2	3.1	1.7	-0.4	1.1	-0.6
Trunk fat mass	1.7	7.3	12.1	3.5	2.0	2.6	-2.5
Waist circumference	0.6	2.2	4.0	2.0	0.9	1.2	-1.6
Number of incorrect matches in round	0.3	0.5	1.8	-1.4	-0.0	-0.2	-0.1
Past tobacco smoking	0.4	0.8	2.4	-0.0	-0.7	1.5	0.5
Alcohol usually taken with meals	0.5	0.9	1.2	0.9	1.1	0.6	-1.0
Nervous feelings	1.3	2.4	4.0	1.5	2.0	0.7	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	0.2	1.0	0.2	-1.0
Hearing difficulty/problems with background noise	0.9	1.4	2.1	1.5	1.4	0.3	-1.2
Hair/balding pattern: Pattern 2	0.8	1.1	2.6	1.6	0.7	0.9	-0.5
Had menopause	0.4	0.5	1.8	0.4	0.1	1.3	0.1
Had other major operations	1.1	1.3	3.2	-0.6	-0.8	-1.8	1.0
Forced vital capacity (FVC)	0.7	2.6	5.6	0.8	-1.7	-2.4	1.0
Heel bone mineral density (BMD) T-score, automated (right)	3.9	8.8	12.0	2.8	3.5	2.0	-3.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.1	0.2	0.3	-0.3	-0.4
Qualifications: None of the above	0.9	2.0	3.8	-1.3	-2.0	-1.2	1.0
Financial difficulties in last 2 years	5.6	7.5	9.8	-2.5	-3.1	-2.1	3.0
Mouth/teeth dental problems	0.2	0.3	0.7	0.3	-0.9	0.2	0.5
Heart attack	0.4	0.5	0.9	-0.8	0.5	1.0	-0.4
Allergy	0.2	0.4	1.0	-1.0	-0.0	0.4	-0.6
Pain all over the body in last month	0.3	0.3	1.2	1.1	-0.0	0.1	-0.1
Diabetes (self-reported)	5.4	8.3	10.9	2.4	3.3	3.1	-2.6
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	3.5	-1.0	-1.0	-1.6	1.9
Medication: Ramipril	1.5	2.0	3.4	-0.6	-1.0	-1.9	1.8
Medication: Simvastatin	0.4	0.5	1.0	-0.9	0.5	1.0	-0.2
Fluid intelligence score	0.4	0.8	1.8	0.6	-0.1	1.4	1.0
Illnesses of siblings	0.6	0.8	1.1	1.0	1.1	0.7	-0.9
Neuroticism score	0.4	0.8	1.4	0.4	1.2	-0.6	-1.2
Weight	0.6	3.0	6.3	2.5	0.8	1.6	-1.6
Impedance of arm (right)	4.7	22.1	33.5	4.7	5.8	4.6	-3.4
Arm fat percentage (right)	0.3	1.0	1.7	1.2	0.5	0.8	-1.3
Trunk fat-free mass	0.4	2.1	5.5	2.4	0.5	0.9	-1.4
Hip circumference	0.1	0.5	1.3	1.1	-0.4	0.8	-0.3
Time employed in main current job	0.7	0.8	1.4	-0.8	-0.8	0.6	1.2
Alcohol intake versus 10 years previously	3.2	4.8	7.5	-2.7	-2.5	-1.3	2.0
Father’s age at death	3.2	4.2	6.5	2.5	1.8	1.6	-2.2
Worrier / anxious feelings	0.3	0.5	1.3	0.4	0.7	0.0	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	0.6	0.3	-1.2	-0.2
Falls in the last year	0.6	0.8	1.8	0.6	1.4	0.8	-0.7
Hair/balding pattern: Pattern 3	1.2	1.7	2.9	-1.7	-1.3	-1.0	1.2
Number of live births	0.9	1.3	3.4	0.2	0.6	-1.8	-1.1
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	10.0	-0.8	-2.1	-3.2	1.8
Pulse rate	1.1	1.8	4.7	0.8	0.8	2.2	-1.1
Happiness	1.1	1.4	2.7	-1.4	-0.8	-1.6	0.7
Noisy workplace	2.8	3.4	4.5	-1.8	-2.1	-1.3	2.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.2	0.2	0.1	0.5	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	1.0	1.2	0.0	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.7	-0.5	-0.0	0.2
Asthma	0.4	0.9	1.7	1.3	1.2	0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.8	-0.2	-1.7	-0.3	0.8
Medication: Cholesterol lowering	1.3	2.1	5.6	-0.1	1.0	2.4	-1.3
Depression (self-reported)	0.7	0.8	1.1	-0.8	-1.1	-0.8	0.9
Medication: Lansoprazole	0.1	0.1	0.4	-0.7	-0.1	0.1	0.2
Prospective memory result	0.5	0.7	1.5	-0.6	-1.2	-0.7	0.6
Lung cancer (father)	0.1	0.2	0.3	-0.4	0.3	-0.5	-0.4
Illnesses of mother	0.5	0.6	0.9	0.9	1.0	0.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	9.2	-1.0	-2.6	-3.0	2.0
Pulse wave Arterial Stiffness index	2.6	3.0	7.9	1.1	0.9	2.8	-1.4
Impedance of arm (left)	4.3	20.1	29.6	4.6	5.4	4.5	-3.1
Arm fat mass (right)	0.3	1.3	2.6	1.6	0.3	0.9	-1.3
Trunk predicted mass	0.3	2.0	5.1	2.3	0.5	0.8	-1.4
Standing height	4.4	44.0	67.4	8.2	6.5	6.4	-5.1
Length of working week for main job	0.7	0.8	1.8	-0.6	-0.9	-0.0	1.3
Exposure to tobacco smoke at home	0.8	0.9	3.0	0.2	0.5	-0.4	-1.7
Breastfed as a baby	0.3	0.4	1.0	-0.3	0.5	0.4	-1.0
Tense / ‘highly strung’	1.3	2.1	3.3	1.8	1.6	-0.4	-1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.2	-0.1	0.3	-1.1	-0.2
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.2	0.1	0.4	-0.4
Birth weight of first child	4.1	7.4	9.8	3.1	2.6	1.9	-3.0
Peak expiratory flow (PEF)	0.4	0.9	1.8	1.3	1.0	0.4	-0.7
Pulse wave reflection index	1.5	1.9	2.4	1.2	1.4	1.6	-1.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.3	0.3	0.4	-0.2
Loud music exposure frequency	0.3	0.3	1.1	0.2	0.2	-1.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	-0.3	0.2	-0.3	1.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.3	1.8	1.0	0.2	-0.9
Blood clot in the leg (DVT)	1.1	1.4	2.9	-1.7	-1.1	-1.1	0.4
Medication: Paracetamol	0.8	1.3	2.6	1.6	0.8	0.9	-1.1
Headache pain in last month	0.1	0.2	0.6	-0.1	-0.2	-0.5	0.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.5	-0.2	-0.2	-1.6	0.7
Glaucoma (self-reported)	4.1	4.8	7.0	1.5	2.5	2.0	-2.6
Gout (self-reported)	0.7	1.0	1.8	-1.3	-0.7	-1.3	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.6	-0.1	0.7	-0.1	0.0
Medication: Amlodipine	1.5	2.1	7.4	0.8	0.1	2.7	-0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.1	0.4	-0.5	-0.3
Birth weight	0.2	0.5	1.4	0.7	-0.3	1.2	-0.3
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.7	1.3	0.4	1.1	-0.5
High blood pressure (siblings)	0.1	0.2	0.4	-0.5	-0.1	-0.0	0.6
Forced vital capacity (FVC), Best measure	0.7	2.5	4.4	0.8	-2.0	-2.1	1.1
Body fat percentage	0.8	3.2	5.1	2.3	1.3	1.7	-1.9
Leg fat percentage (right)	0.3	0.9	2.2	1.0	0.5	0.6	-1.5
Arm fat-free mass (right)	0.2	0.8	2.4	1.5	-0.3	0.5	-0.7
Exposure to tobacco smoke outside home	0.2	0.3	1.1	-0.2	-1.0	-0.2	-0.1
Comparative body size at age 10	1.5	4.2	7.0	-2.0	-2.6	-1.4	1.9
Number of full brothers	0.7	0.9	2.1	0.6	1.4	0.6	-0.9
Worry too long after embarrassment	0.6	1.1	2.0	1.2	1.4	-0.2	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.4	-1.2	-0.8	-1.8	1.1
Wheeze or whistling in the chest in last year	0.7	1.2	1.8	1.3	1.3	-0.1	-1.2
Number of children fathered	1.4	1.6	2.0	1.1	1.3	1.4	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.1	-0.1	0.5	0.2
Age at first live birth	0.2	0.3	0.9	0.4	0.1	0.9	0.4
Pulse wave peak to peak time	1.6	1.9	5.5	-0.5	-0.7	-2.4	1.1
Health satisfaction	0.7	0.9	1.7	-0.9	-0.9	-1.3	0.7
Shortness of breath walking on level ground	0.7	0.9	2.9	-0.1	-0.4	-1.7	0.6
Qualifications: College or University degree	1.2	3.8	6.0	2.5	1.7	2.0	-1.5
Eye problems/disorders: None of the above	3.9	4.5	6.3	-2.2	-1.2	-2.3	2.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.6	-0.8	-0.7	-0.8	0.3
Emphysema/chronic bronchitis	1.1	1.2	2.6	1.6	1.1	0.5	-0.9
Medication for pain relief, constipation, heartburn	0.3	0.4	0.9	-0.2	0.9	-1.0	0.0
Neck or shoulder pain in last month	1.0	1.4	2.6	-1.6	-1.0	-0.4	1.4
Medication: Blood pressure	0.2	0.4	0.8	0.4	0.2	0.9	-0.8
Angina (self-reported)	0.1	0.2	0.4	-0.6	0.2	0.1	-0.5
Migraine (self-reported)	2.1	2.6	4.4	-0.7	-1.8	-2.1	1.5
Medication: Ibuprofen	1.4	1.7	3.9	-0.8	-2.0	-1.3	0.7
Medication: Allopurinol	0.3	0.4	1.0	-0.6	0.1	-1.0	-0.3
Medication: Omeprazole	2.1	2.5	3.1	-1.4	-1.7	-1.7	1.5
Medication: Seretide 50 evohaler	0.1	0.2	0.3	0.3	0.4	0.4	-0.5
Mean time to correctly identify matches	0.1	0.2	0.6	-0.0	-0.1	-0.5	-0.8
Heart disease (mother)	1.8	2.2	3.8	-1.1	-2.0	-1.2	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.8	6.7	1.3	2.5	0.4	-2.6
Whole body fat mass	0.9	3.7	6.5	2.5	1.1	1.7	-2.0
Leg fat mass (right)	0.4	1.7	2.7	1.6	0.4	1.1	-1.6
Arm predicted mass (right)	0.2	0.9	2.5	1.6	-0.5	0.5	-0.6
Pulse rate, automated reading	3.5	11.1	15.7	2.7	2.8	4.0	-3.6
Alcohol intake frequency.	1.1	2.4	4.3	-2.1	-0.5	-1.8	1.4
Comparative height size at age 10	4.9	27.2	36.7	6.1	5.7	4.3	-4.6
Number of full sisters	0.6	0.7	2.0	-0.7	-0.3	-1.4	0.2
Suffer from ‘nerves’	0.4	0.7	2.2	-0.6	-0.2	-1.5	0.3
Overall health rating	0.5	1.1	2.2	-1.0	-0.9	-1.5	0.5
Chest pain or discomfort	0.5	0.7	1.7	0.7	1.3	0.6	-0.4
Had major operations	0.2	0.2	0.5	0.5	0.4	-0.7	0.3
Age at last live birth	0.1	0.1	0.1	0.4	-0.3	-0.4	0.1
Family relationship satisfaction	0.7	0.8	2.9	-0.2	0.5	-1.7	-0.3
Leg pain on walking	0.1	0.1	0.3	-0.1	0.1	-0.5	0.3
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	8.1	-1.0	-0.3	-2.8	0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	-0.0	-0.0	0.2	-0.5
Illness, injury, bereavement, stress in last 2 years	1.3	1.5	2.4	1.4	1.5	0.5	-1.3
Medication: Aspirin	1.0	1.3	1.9	0.7	1.1	1.2	-1.4
Supplements: Vitamin C	0.2	0.2	0.4	0.4	0.2	0.7	-0.2
Knee pain experienced in last month	0.3	0.4	1.0	0.5	-0.3	-1.0	-0.4
Hypertension (Self-reported)	0.4	1.2	4.0	-0.6	-0.6	2.0	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	-0.1	-0.3	-0.7	0.1
Illnesses of father: Heart disease	0.2	0.3	0.7	0.2	0.5	0.9	-0.3
Illnesses of siblings: Diabetes	2.0	2.5	4.6	1.3	2.1	1.2	-1.5
Smoking status: Previous	0.9	1.3	4.2	-0.9	-0.3	-2.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	7.4	2.7	2.1	1.3	-1.2
Whole body fat-free mass	0.3	1.5	4.2	2.1	0.1	1.0	-1.0
Leg fat-free mass (right)	0.2	0.9	2.1	1.5	-0.6	0.9	-0.3
Arm fat percentage (left)	0.1	0.6	0.9	0.9	0.1	0.7	-0.9
Average weekly red wine intake	3.7	5.4	6.6	2.6	2.4	2.4	-1.9
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.2	-0.2	0.8	-0.4	-1.5
Mood swings	0.1	0.2	0.6	0.1	0.0	-0.8	-0.5
Loneliness, isolation	0.1	0.1	0.3	-0.3	-0.4	-0.3	0.5
Long-standing illness, disability or infirmity	0.1	0.2	0.5	0.0	0.7	-0.5	0.1
Ever had bowel cancer screening	0.6	0.7	2.4	-0.1	-0.2	1.6	0.4
Diabetes diagnosed by doctor	4.4	7.2	10.8	2.0	2.9	3.3	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.3	0.5	0.9	-0.3	-1.1
Friendships satisfaction	0.5	0.7	1.0	-0.6	-0.8	-1.0	0.7
Qualifications: nursing, teaching	0.3	0.5	1.1	0.4	0.8	1.1	-0.2
Commuting to job workplace: Walk	2.1	2.2	5.3	-0.8	-0.6	-1.6	2.3
Eye problems/disorders: Cataract	5.8	6.7	11.6	2.7	1.5	2.4	-3.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.9	0.0	0.8	1.0	-0.3
Medication for cholesterol	0.9	1.3	1.9	1.4	1.2	-0.8	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.7	0.3	1.6	0.2	-1.1
Back pain experienced in last month	0.2	0.3	0.7	-0.5	-0.5	-0.8	-0.4
Mineral and other dietary supplements	0.7	1.0	1.2	-1.1	-0.9	-0.9	1.1
Breast cancer (self-reported)	2.1	2.5	3.7	1.9	1.2	1.9	-1.2
Asthma (self-reported)	0.5	1.0	1.9	1.4	1.3	0.3	-0.4
Osteoporosis (self-reported)	0.7	0.8	1.4	-0.4	1.2	0.9	-0.9
Osteoarthritis (self-reported)	0.7	0.9	1.6	-0.6	-1.2	-0.6	1.1
Medication: Aspirin	2.1	2.8	4.1	1.1	1.6	1.8	-2.0
Medication: Gliclazide	0.6	0.6	1.0	-0.1	1.0	0.9	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.3	0.9	0.4	-0.4	-1.0	0.2
Smoking status: Current	0.8	1.3	1.7	1.3	1.3	0.9	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.3	7.5	-2.5	-2.2	-2.7	1.7
Whole body water mass	0.2	1.3	3.7	1.9	-0.1	0.8	-0.9
Leg predicted mass (right)	0.2	0.9	2.1	1.4	-0.6	1.0	-0.3
Arm fat mass (left)	0.3	1.1	2.2	1.5	0.1	0.9	-1.1
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	-1.0	-0.5	-0.3	0.8
Average weekly champagne plus white wine intake	0.3	0.4	0.9	0.2	1.0	0.1	-0.8
Miserableness	0.0	0.1	0.2	0.1	0.2	-0.4	-0.4
Guilty feelings	0.5	0.8	1.6	0.4	0.7	-1.3	-1.0
Wears glasses or contact lenses	7.1	8.2	10.6	2.9	3.3	2.9	-2.2
Ever taken oral contraceptive pill	1.3	1.5	3.2	1.2	1.1	-0.2	-1.8
Hearing aid user	0.1	0.1	0.2	-0.4	-0.1	0.0	0.5
Mother’s age at death	0.1	0.1	0.2	0.3	-0.5	-0.4	-0.2
Financial situation satisfaction	1.1	1.4	3.0	-1.0	-1.7	-0.2	1.2
Tinnitus: Yes, now most or all of the time	2.0	2.4	4.1	-2.0	-1.4	-1.3	1.4
Commuting to job workplace: Public transport	0.5	0.6	1.3	-0.5	-1.1	-0.6	0.6
Eye problems/disorders: Glaucoma	3.3	3.9	5.8	1.2	2.4	1.7	-2.4
Medication: Blood pressure	0.9	1.8	2.4	-1.0	-1.5	1.5	1.2
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.1	0.6	2.3	1.1	-1.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	0.4	0.8	0.3	-0.6
High cholesterol (Self-reported)	0.0	0.1	0.2	-0.4	0.1	0.3	0.1
Medication: Bendroflumethiazide	1.2	1.9	5.6	-0.4	-1.0	2.4	0.9
Medication: Paracetamol	0.8	1.3	2.1	1.1	1.1	0.6	-1.5
Medication: Lisinopril	0.6	0.7	1.0	-1.0	-0.9	0.9	0.4
Medication: Atorvastatin	0.3	0.4	0.7	-0.8	-0.8	-0.3	0.5
Illnesses of father: High blood pressure	1.5	1.8	2.7	-1.6	-1.4	-0.9	1.3
Alcohol drinker status: Never	0.1	0.2	0.6	-0.8	-0.0	-0.2	-0.1
Ever smoked	0.3	0.4	1.7	0.2	0.1	-1.3	0.1
Basal metabolic rate	0.3	1.6	4.5	2.1	0.1	0.9	-1.0
Leg fat percentage (left)	0.1	0.4	1.1	0.6	0.2	0.3	-1.1
Arm fat-free mass (left)	0.2	1.0	3.0	1.7	-0.2	0.4	-0.8
Number of operations (self-reported)	0.6	0.8	1.2	-0.2	-1.0	-1.0	1.1
Average weekly beer plus cider intake	4.1	6.0	7.7	-2.3	-2.8	-2.7	1.9
Irritability	0.2	0.4	0.7	-0.8	-0.6	-0.7	0.4
Risk taking	0.3	0.4	1.7	0.1	0.3	1.3	0.2
Ever had prostate specific antigen (PSA) test	2.1	2.5	4.5	0.6	2.1	1.5	-1.6
Fractured/broken bones in last 5 years	0.1	0.2	0.2	-0.4	0.4	-0.3	-0.5
Age started oral contraceptive pill	3.1	3.9	6.4	1.5	1.7	2.5	-2.0
Diastolic blood pressure, automated reading	0.9	2.9	7.0	1.5	-0.7	2.6	-1.4
Ever depressed for a whole week	1.7	2.1	3.1	-1.6	-1.4	-0.9	1.8
Unable to work because of sickness or disability	3.0	3.9	6.6	-1.2	-2.6	-1.8	2.0
Commuting to job workplace: Cycle	0.3	0.3	0.8	-0.7	-0.0	-0.3	0.9
Myopia	0.0	0.1	0.1	0.3	-0.2	-0.1	0.3
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.5	1.0	0.6	-1.6	0.2
Cholesterol lowering medication	0.7	1.1	2.4	-1.6	-0.8	-0.6	1.0
Medication: Omeprazole (e.g. Zanprol)	2.5	3.0	4.4	-1.7	-2.1	-1.4	1.6
Pain experienced in last month	0.0	0.0	0.1	0.0	0.1	0.2	0.3
Supplements: Calcium	1.6	1.7	3.0	1.0	1.0	1.7	-1.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.5	0.2	-0.7	-0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	-0.8	0.6	0.9	-0.5
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	4.8	-2.2	-1.5	-1.2	0.7
Heart disease (siblings)	0.7	0.8	1.5	-1.1	-1.2	-0.0	0.7
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.4	0.5	-0.2	-0.6
Pack years of smoking	1.0	1.4	3.5	0.9	0.7	1.0	-1.9
Impedance of whole body	4.0	20.4	33.0	4.6	5.7	4.0	-3.4
Leg fat mass (left)	0.3	1.1	2.0	1.4	0.1	0.8	-1.3
Arm predicted mass (left)	0.2	1.0	3.0	1.7	-0.1	0.4	-0.9