Hub : Genes

BOP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.0960 0.0460 7.5e-03 0.060 NA 0.059 NA 0.065 3.3e-04 NA 3.5e-04 NA 1.8e-04
2 GTEx Thyroid 0.1890 0.0500 8.7e-09 0.095 NA 0.153 NA 0.145 9.4e-08 NA 8.8e-12 NA 3.3e-11
3 YFS Blood 0.0321 0.0128 1.6e-04 0.003 0.015 0.013 0.016 0.009 2.5e-02 7.6e-06 3.4e-05 5.2e-06 4.7e-04
4 TCGA Skin Cutaneous Melanoma 0.1270 0.1090 7.3e-03 0.046 -0.011 0.005 NA -0.010 2.3e-02 8.5e-01 2.3e-01 NA 7.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.7 2.7 0.2 1.7 0.1 -0.4
Bipolar Disorder or Schizophrenia 0.4 1.1 2.9 -1.0 0.2 -1.7 0.6
Depressed Affect (Nagel 2018) 0.1 0.2 0.5 0.1 -0.0 -0.7 -0.4
Depression (Nagel 2018) 0.8 1.3 2.4 1.5 1.1 -0.1 -1.2
Intelligence (Savage-Jansen 2018) 0.5 1.5 3.8 1.3 0.7 1.9 0.3
Neuroticism (Nagel 2018) 0.5 1.1 1.6 0.9 1.1 -0.8 -1.3
Schizophrenia (2018) 1.2 2.5 5.4 -1.5 -1.1 -2.3 1.1
Schizophrenia vs Biploar Disorder 0.0 0.1 0.3 0.0 0.0 0.0 0.5
Worry (Nagel 2018) 0.6 1.3 2.2 0.9 1.5 -0.4 -1.5
Alzheimer’s Disease (in mother) 0.4 0.5 1.6 -1.3 -0.2 -0.4 0.2
Alzheimer’s Disease (in father) 0.5 0.5 1.6 1.3 0.4 0.5 -0.2
Alzheimer’s Disease (including proxy) 0.2 0.3 1.1 -0.1 1.0 0.2 -0.4
Crohns Disease (2017) 3.3 7.1 14.8 2.2 3.8 1.5 -2.6
Irritable Bowel Disease (IBD) 3.5 8.4 17.4 2.2 4.2 1.2 -3.1
Ulcerative Colitis (UC) 1.8 3.4 7.2 1.2 2.7 0.7 -2.1
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.2 0.4 1.2 -0.3 -0.5 -1.1 -0.3
Verbal and Numeric Reasoning (VNR) 0.7 1.7 4.7 1.1 -0.2 2.2 1.0
Breast Cancer 0.0 0.1 0.3 0.1 -0.2 0.5 0.1
Ovarian Cancer 0.5 0.6 1.2 -0.5 -0.6 -0.8 1.1
Prostate Cancer 0.2 0.3 0.6 0.8 -0.0 0.6 -0.3
Age at First Birth 1.0 1.5 2.8 1.7 0.7 1.7 0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.6 0.8 1.7 -0.8 -0.9 -1.3 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 4.1 6.6 15.2 3.9 0.0 3.3 0.0
Mean Putamen Volume 0.4 0.4 1.2 -0.2 1.1 0.5 -0.3
Fasting Glucose 0.2 0.2 0.8 -0.2 0.9 0.4 -0.1
HbA1C 1.5 1.6 3.2 1.8 1.3 1.2 0.0
HDL Cholesterol 1.2 1.9 2.8 -1.6 -1.7 -1.5 0.0
LDL Cholesterol 0.6 0.9 3.0 -1.7 -0.3 -0.8 0.0
Lupus 1.5 2.3 4.4 2.0 0.7 2.1 -0.6
Neuroticism (2016) 0.6 0.9 2.1 0.1 1.5 -0.0 -1.1
Primary Biliary Cirrhosis 2.2 3.2 4.8 1.5 2.1 1.1 -2.2
Rheumatoid Arthritis 2.1 2.9 4.6 2.2 1.7 -0.3 -2.0
Schizophrenia (2014) 0.5 1.2 2.4 0.6 1.2 -1.6 -0.7
Triglycerides 0.0 0.1 0.1 0.2 -0.3 -0.4 0.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.2 0.3 1.0 0.0 0.0 1.0 0.0
Blood Eosinophil Count 1.7 13.2 21.3 3.4 4.6 1.6 -4.2
Blood Platelet Count 2.4 28.3 55.1 -7.4 -4.0 -5.3 3.6
Blood Red Count 0.4 3.9 10.5 2.0 0.5 3.2 -1.1
Blood White Count 0.1 1.1 1.7 -1.3 0.1 -1.3 -0.9
Heel T-Score 2.1 16.7 22.1 2.7 4.7 4.7 -3.9
BMI 0.5 3.1 7.7 -1.6 -2.8 -1.2 0.7
Height 4.4 84.0 144.0 12.0 8.1 8.6 -7.2
Waist Hip Ratio (WHR) 2.7 12.4 16.6 4.1 4.1 2.5 -3.1
Systolic Blood Pressure 0.3 1.4 2.5 -0.9 -1.5 1.6 0.6
Smoking Status 1.0 2.4 4.0 2.0 2.0 -0.5 -1.3
Allergy or Eczema 0.1 0.3 0.6 0.6 0.2 -0.2 0.7
Cardiovascular Disease 0.6 2.0 6.1 -0.8 -0.9 2.5 0.5
Hypothyroidism (self reported) 0.1 0.2 0.7 -0.1 0.8 -0.4 -0.1
Respiratory disease 0.4 0.9 2.6 1.6 0.8 -0.0 -0.5
Type 2 Diabetes (T2D) (2018) 4.1 7.8 11.8 2.1 3.0 3.4 -2.4
Lung FEV1/FVC ratio 0.6 3.0 8.1 -2.9 -0.5 -1.4 1.3
Lung FVC 8.7 44.4 65.0 -5.0 -8.1 -7.7 5.3
Neuroticism 1.4 3.3 5.8 1.4 2.4 0.2 -2.3
Chronotype (morning person) 0.7 1.6 3.6 0.4 1.6 0.3 -1.9
Hair Pigment 0.1 1.6 2.5 1.6 1.2 0.6 -1.4
Tanning 0.2 2.3 2.7 1.6 1.3 1.5 -1.6
Hand grip strength (left) 0.6 1.5 3.2 1.8 1.4 -0.3 -1.0
Number of treatments/medications taken 0.2 0.3 1.1 -0.2 0.1 1.1 -0.2
Average weekly spirits intake 0.5 0.7 1.0 0.1 0.9 -0.9 -1.0
Sensitivity / hurt feelings 0.5 0.8 1.3 0.4 1.1 -0.7 -1.1
Frequency of depressed mood in last 2 weeks 0.4 0.5 0.9 0.7 0.8 -0.3 -0.9
Hearing difficulty/problems: Yes 0.6 1.0 1.6 -0.4 -1.2 -1.1 1.0
Relative age of first facial hair 0.7 1.3 4.1 2.0 -0.4 1.0 0.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.7 -0.5 -0.3 -0.9 0.2
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 -0.3 -0.2 0.4 -0.4
Ever had hysterectomy (womb removed) 2.7 3.0 5.5 2.4 1.7 1.3 -1.4
Systolic blood pressure, automated reading 0.4 1.0 3.1 0.0 -0.5 1.8 -0.9
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 0.9 -0.9 -0.4 0.8 0.9
Angina 0.2 0.2 0.7 -0.8 0.2 0.1 -0.5
Medication for hormone replacement therapy 1.0 1.1 2.7 -1.7 -1.1 0.2 0.7
Vitamin and mineral supplements 0.0 0.0 0.1 -0.0 -0.1 -0.2 -0.2
Supplements: Zinc 0.1 0.1 0.3 0.3 -0.2 -0.6 0.3
Medication: Co-codamol 0.6 0.7 2.2 -0.4 -0.5 -1.5 -0.6
Medication: Metformin 3.4 4.8 6.2 1.6 2.5 2.5 -2.0
Diabetes (father) 2.0 2.4 3.0 1.5 1.6 1.7 -1.4
Diabetes (mother) 0.1 0.2 0.6 0.3 -0.2 0.8 0.0
Severe depression (siblings) 1.9 2.2 2.7 -1.5 -1.5 -1.2 1.6
Pack years adult smoking proportion 0.7 1.1 2.7 0.8 0.4 0.9 -1.6
Impedance of leg (right) 3.0 14.5 25.4 3.8 5.0 2.8 -3.3
Leg fat-free mass (left) 0.2 1.2 3.0 1.7 -0.4 1.2 -0.5
Trunk fat percentage 1.8 7.1 10.4 3.2 2.2 2.7 -2.4
Hand grip strength (right) 0.2 0.6 1.1 1.1 -0.2 -1.1 0.5
Townsend deprivation index at recruitment 0.7 1.0 2.5 -1.6 -0.2 -0.8 1.0
Current tobacco smoking 0.7 1.1 1.5 1.2 1.2 0.7 -0.9
Average weekly fortified wine intake 1.2 1.4 3.8 2.0 1.0 0.8 -0.4
Maternal smoking around birth 8.8 12.8 20.0 4.5 3.2 2.3 -3.9
Fed-up feelings 0.5 1.0 2.5 -0.9 -0.6 -1.6 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.5 1.6 1.2 -0.6 -1.0
Relative age voice broke 0.5 0.8 2.9 1.7 -0.6 -0.1 0.3
Taking other prescription medications 0.3 0.4 1.2 -0.1 1.1 0.6 -0.3
Age when periods started (menarche) 0.7 1.7 4.2 1.3 1.0 2.0 -0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.4 -0.6 -0.6 0.5 0.5
Heel bone mineral density (BMD) T-score, automated (left) 3.8 8.5 12.0 2.8 3.5 1.7 -3.4
Tinnitus: Yes, but not now, but have in the past 2.2 2.3 3.7 1.9 1.7 0.1 -1.6
Qualifications: CSEs or equivalent 2.2 2.8 7.3 -1.5 -1.0 -2.7 0.8
Serious illness, injury or assault to yourself 1.7 2.0 2.8 -0.9 -1.5 -1.5 1.7
High blood pressure 0.4 1.2 3.1 -0.8 -0.9 1.8 -0.1
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.5 0.7 0.5 -0.2 0.7
Multivitamins +/- minerals 0.5 0.7 1.2 0.6 1.1 1.0 -0.4
Stomach or abdominal pain in last month 0.6 0.8 1.6 -0.9 -0.6 -0.5 1.3
Supplements: Glucosamine 0.7 0.9 1.5 1.2 0.7 1.2 -0.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.3 -0.1 -0.5 1.1 0.6
Medication: Atenolol 0.3 0.4 1.2 -1.1 -0.6 -0.1 0.3
Medication: Levothyroxine sodium 0.1 0.2 0.5 -0.6 -0.2 -0.1 0.7
Sitting height 5.8 41.1 54.5 7.4 6.6 5.9 -5.6
Chronic bronchitis/emphysema (father) 0.2 0.3 0.6 -0.5 -0.4 0.8 -0.2
High blood pressure (mother) 3.1 4.3 5.6 -2.4 -1.9 -1.6 2.4
Body mass index (BMI) 0.4 1.6 4.4 -1.0 -2.1 -1.0 0.5
Impedance of leg (left) 2.5 12.3 22.8 3.4 4.8 2.4 -2.9
Leg predicted mass (left) 0.2 1.2 3.1 1.7 -0.4 1.1 -0.6
Trunk fat mass 1.7 7.3 12.1 3.5 2.0 2.6 -2.5
Waist circumference 0.6 2.2 4.0 2.0 0.9 1.2 -1.6
Number of incorrect matches in round 0.3 0.5 1.8 -1.4 -0.0 -0.2 -0.1
Past tobacco smoking 0.4 0.8 2.4 -0.0 -0.7 1.5 0.5
Alcohol usually taken with meals 0.5 0.9 1.2 0.9 1.1 0.6 -1.0
Nervous feelings 1.3 2.4 4.0 1.5 2.0 0.7 -1.7
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.0 0.2 1.0 0.2 -1.0
Hearing difficulty/problems with background noise 0.9 1.4 2.1 1.5 1.4 0.3 -1.2
Hair/balding pattern: Pattern 2 0.8 1.1 2.6 1.6 0.7 0.9 -0.5
Had menopause 0.4 0.5 1.8 0.4 0.1 1.3 0.1
Had other major operations 1.1 1.3 3.2 -0.6 -0.8 -1.8 1.0
Forced vital capacity (FVC) 0.7 2.6 5.6 0.8 -1.7 -2.4 1.0
Heel bone mineral density (BMD) T-score, automated (right) 3.9 8.8 12.0 2.8 3.5 2.0 -3.4
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.1 0.2 0.3 -0.3 -0.4
Qualifications: None of the above 0.9 2.0 3.8 -1.3 -2.0 -1.2 1.0
Financial difficulties in last 2 years 5.6 7.5 9.8 -2.5 -3.1 -2.1 3.0
Mouth/teeth dental problems 0.2 0.3 0.7 0.3 -0.9 0.2 0.5
Heart attack 0.4 0.5 0.9 -0.8 0.5 1.0 -0.4
Allergy 0.2 0.4 1.0 -1.0 -0.0 0.4 -0.6
Pain all over the body in last month 0.3 0.3 1.2 1.1 -0.0 0.1 -0.1
Diabetes (self-reported) 5.4 8.3 10.9 2.4 3.3 3.1 -2.6
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 3.5 -1.0 -1.0 -1.6 1.9
Medication: Ramipril 1.5 2.0 3.4 -0.6 -1.0 -1.9 1.8
Medication: Simvastatin 0.4 0.5 1.0 -0.9 0.5 1.0 -0.2
Fluid intelligence score 0.4 0.8 1.8 0.6 -0.1 1.4 1.0
Illnesses of siblings 0.6 0.8 1.1 1.0 1.1 0.7 -0.9
Neuroticism score 0.4 0.8 1.4 0.4 1.2 -0.6 -1.2
Weight 0.6 3.0 6.3 2.5 0.8 1.6 -1.6
Impedance of arm (right) 4.7 22.1 33.5 4.7 5.8 4.6 -3.4
Arm fat percentage (right) 0.3 1.0 1.7 1.2 0.5 0.8 -1.3
Trunk fat-free mass 0.4 2.1 5.5 2.4 0.5 0.9 -1.4
Hip circumference 0.1 0.5 1.3 1.1 -0.4 0.8 -0.3
Time employed in main current job 0.7 0.8 1.4 -0.8 -0.8 0.6 1.2
Alcohol intake versus 10 years previously 3.2 4.8 7.5 -2.7 -2.5 -1.3 2.0
Father’s age at death 3.2 4.2 6.5 2.5 1.8 1.6 -2.2
Worrier / anxious feelings 0.3 0.5 1.3 0.4 0.7 0.0 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 1.4 0.6 0.3 -1.2 -0.2
Falls in the last year 0.6 0.8 1.8 0.6 1.4 0.8 -0.7
Hair/balding pattern: Pattern 3 1.2 1.7 2.9 -1.7 -1.3 -1.0 1.2
Number of live births 0.9 1.3 3.4 0.2 0.6 -1.8 -1.1
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 10.0 -0.8 -2.1 -3.2 1.8
Pulse rate 1.1 1.8 4.7 0.8 0.8 2.2 -1.1
Happiness 1.1 1.4 2.7 -1.4 -0.8 -1.6 0.7
Noisy workplace 2.8 3.4 4.5 -1.8 -2.1 -1.3 2.1
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.2 0.2 0.1 0.5 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.5 1.0 1.2 0.0 -0.7
Mouth/teeth dental problems: Dentures 0.1 0.2 0.5 -0.7 -0.5 -0.0 0.2
Asthma 0.4 0.9 1.7 1.3 1.2 0.4 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.8 -0.2 -1.7 -0.3 0.8
Medication: Cholesterol lowering 1.3 2.1 5.6 -0.1 1.0 2.4 -1.3
Depression (self-reported) 0.7 0.8 1.1 -0.8 -1.1 -0.8 0.9
Medication: Lansoprazole 0.1 0.1 0.4 -0.7 -0.1 0.1 0.2
Prospective memory result 0.5 0.7 1.5 -0.6 -1.2 -0.7 0.6
Lung cancer (father) 0.1 0.2 0.3 -0.4 0.3 -0.5 -0.4
Illnesses of mother 0.5 0.6 0.9 0.9 1.0 0.2 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.2 9.2 -1.0 -2.6 -3.0 2.0
Pulse wave Arterial Stiffness index 2.6 3.0 7.9 1.1 0.9 2.8 -1.4
Impedance of arm (left) 4.3 20.1 29.6 4.6 5.4 4.5 -3.1
Arm fat mass (right) 0.3 1.3 2.6 1.6 0.3 0.9 -1.3
Trunk predicted mass 0.3 2.0 5.1 2.3 0.5 0.8 -1.4
Standing height 4.4 44.0 67.4 8.2 6.5 6.4 -5.1
Length of working week for main job 0.7 0.8 1.8 -0.6 -0.9 -0.0 1.3
Exposure to tobacco smoke at home 0.8 0.9 3.0 0.2 0.5 -0.4 -1.7
Breastfed as a baby 0.3 0.4 1.0 -0.3 0.5 0.4 -1.0
Tense / ‘highly strung’ 1.3 2.1 3.3 1.8 1.6 -0.4 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.2 -0.1 0.3 -1.1 -0.2
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 0.2 0.1 0.4 -0.4
Birth weight of first child 4.1 7.4 9.8 3.1 2.6 1.9 -3.0
Peak expiratory flow (PEF) 0.4 0.9 1.8 1.3 1.0 0.4 -0.7
Pulse wave reflection index 1.5 1.9 2.4 1.2 1.4 1.6 -1.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 0.3 0.3 0.4 -0.2
Loud music exposure frequency 0.3 0.3 1.1 0.2 0.2 -1.1 -0.1
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.0 -0.3 0.2 -0.3 1.0
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 3.3 1.8 1.0 0.2 -0.9
Blood clot in the leg (DVT) 1.1 1.4 2.9 -1.7 -1.1 -1.1 0.4
Medication: Paracetamol 0.8 1.3 2.6 1.6 0.8 0.9 -1.1
Headache pain in last month 0.1 0.2 0.6 -0.1 -0.2 -0.5 0.8
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.5 -0.2 -0.2 -1.6 0.7
Glaucoma (self-reported) 4.1 4.8 7.0 1.5 2.5 2.0 -2.6
Gout (self-reported) 0.7 1.0 1.8 -1.3 -0.7 -1.3 0.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.6 -0.1 0.7 -0.1 0.0
Medication: Amlodipine 1.5 2.1 7.4 0.8 0.1 2.7 -0.6
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.3 -0.1 0.4 -0.5 -0.3
Birth weight 0.2 0.5 1.4 0.7 -0.3 1.2 -0.3
Chronic bronchitis/emphysema (mother) 0.7 0.9 1.7 1.3 0.4 1.1 -0.5
High blood pressure (siblings) 0.1 0.2 0.4 -0.5 -0.1 -0.0 0.6
Forced vital capacity (FVC), Best measure 0.7 2.5 4.4 0.8 -2.0 -2.1 1.1
Body fat percentage 0.8 3.2 5.1 2.3 1.3 1.7 -1.9
Leg fat percentage (right) 0.3 0.9 2.2 1.0 0.5 0.6 -1.5
Arm fat-free mass (right) 0.2 0.8 2.4 1.5 -0.3 0.5 -0.7
Exposure to tobacco smoke outside home 0.2 0.3 1.1 -0.2 -1.0 -0.2 -0.1
Comparative body size at age 10 1.5 4.2 7.0 -2.0 -2.6 -1.4 1.9
Number of full brothers 0.7 0.9 2.1 0.6 1.4 0.6 -0.9
Worry too long after embarrassment 0.6 1.1 2.0 1.2 1.4 -0.2 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 3.4 -1.2 -0.8 -1.8 1.1
Wheeze or whistling in the chest in last year 0.7 1.2 1.8 1.3 1.3 -0.1 -1.2
Number of children fathered 1.4 1.6 2.0 1.1 1.3 1.4 -1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.3 0.1 -0.1 0.5 0.2
Age at first live birth 0.2 0.3 0.9 0.4 0.1 0.9 0.4
Pulse wave peak to peak time 1.6 1.9 5.5 -0.5 -0.7 -2.4 1.1
Health satisfaction 0.7 0.9 1.7 -0.9 -0.9 -1.3 0.7
Shortness of breath walking on level ground 0.7 0.9 2.9 -0.1 -0.4 -1.7 0.6
Qualifications: College or University degree 1.2 3.8 6.0 2.5 1.7 2.0 -1.5
Eye problems/disorders: None of the above 3.9 4.5 6.3 -2.2 -1.2 -2.3 2.5
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.6 -0.8 -0.7 -0.8 0.3
Emphysema/chronic bronchitis 1.1 1.2 2.6 1.6 1.1 0.5 -0.9
Medication for pain relief, constipation, heartburn 0.3 0.4 0.9 -0.2 0.9 -1.0 0.0
Neck or shoulder pain in last month 1.0 1.4 2.6 -1.6 -1.0 -0.4 1.4
Medication: Blood pressure 0.2 0.4 0.8 0.4 0.2 0.9 -0.8
Angina (self-reported) 0.1 0.2 0.4 -0.6 0.2 0.1 -0.5
Migraine (self-reported) 2.1 2.6 4.4 -0.7 -1.8 -2.1 1.5
Medication: Ibuprofen 1.4 1.7 3.9 -0.8 -2.0 -1.3 0.7
Medication: Allopurinol 0.3 0.4 1.0 -0.6 0.1 -1.0 -0.3
Medication: Omeprazole 2.1 2.5 3.1 -1.4 -1.7 -1.7 1.5
Medication: Seretide 50 evohaler 0.1 0.2 0.3 0.3 0.4 0.4 -0.5
Mean time to correctly identify matches 0.1 0.2 0.6 -0.0 -0.1 -0.5 -0.8
Heart disease (mother) 1.8 2.2 3.8 -1.1 -2.0 -1.2 1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.2 3.8 6.7 1.3 2.5 0.4 -2.6
Whole body fat mass 0.9 3.7 6.5 2.5 1.1 1.7 -2.0
Leg fat mass (right) 0.4 1.7 2.7 1.6 0.4 1.1 -1.6
Arm predicted mass (right) 0.2 0.9 2.5 1.6 -0.5 0.5 -0.6
Pulse rate, automated reading 3.5 11.1 15.7 2.7 2.8 4.0 -3.6
Alcohol intake frequency. 1.1 2.4 4.3 -2.1 -0.5 -1.8 1.4
Comparative height size at age 10 4.9 27.2 36.7 6.1 5.7 4.3 -4.6
Number of full sisters 0.6 0.7 2.0 -0.7 -0.3 -1.4 0.2
Suffer from ‘nerves’ 0.4 0.7 2.2 -0.6 -0.2 -1.5 0.3
Overall health rating 0.5 1.1 2.2 -1.0 -0.9 -1.5 0.5
Chest pain or discomfort 0.5 0.7 1.7 0.7 1.3 0.6 -0.4
Had major operations 0.2 0.2 0.5 0.5 0.4 -0.7 0.3
Age at last live birth 0.1 0.1 0.1 0.4 -0.3 -0.4 0.1
Family relationship satisfaction 0.7 0.8 2.9 -0.2 0.5 -1.7 -0.3
Leg pain on walking 0.1 0.1 0.3 -0.1 0.1 -0.5 0.3
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 8.1 -1.0 -0.3 -2.8 0.6
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 -0.0 -0.0 0.2 -0.5
Illness, injury, bereavement, stress in last 2 years 1.3 1.5 2.4 1.4 1.5 0.5 -1.3
Medication: Aspirin 1.0 1.3 1.9 0.7 1.1 1.2 -1.4
Supplements: Vitamin C 0.2 0.2 0.4 0.4 0.2 0.7 -0.2
Knee pain experienced in last month 0.3 0.4 1.0 0.5 -0.3 -1.0 -0.4
Hypertension (Self-reported) 0.4 1.2 4.0 -0.6 -0.6 2.0 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.5 -0.1 -0.3 -0.7 0.1
Illnesses of father: Heart disease 0.2 0.3 0.7 0.2 0.5 0.9 -0.3
Illnesses of siblings: Diabetes 2.0 2.5 4.6 1.3 2.1 1.2 -1.5
Smoking status: Previous 0.9 1.3 4.2 -0.9 -0.3 -2.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 7.4 2.7 2.1 1.3 -1.2
Whole body fat-free mass 0.3 1.5 4.2 2.1 0.1 1.0 -1.0
Leg fat-free mass (right) 0.2 0.9 2.1 1.5 -0.6 0.9 -0.3
Arm fat percentage (left) 0.1 0.6 0.9 0.9 0.1 0.7 -0.9
Average weekly red wine intake 3.7 5.4 6.6 2.6 2.4 2.4 -1.9
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.2 -0.2 0.8 -0.4 -1.5
Mood swings 0.1 0.2 0.6 0.1 0.0 -0.8 -0.5
Loneliness, isolation 0.1 0.1 0.3 -0.3 -0.4 -0.3 0.5
Long-standing illness, disability or infirmity 0.1 0.2 0.5 0.0 0.7 -0.5 0.1
Ever had bowel cancer screening 0.6 0.7 2.4 -0.1 -0.2 1.6 0.4
Diabetes diagnosed by doctor 4.4 7.2 10.8 2.0 2.9 3.3 -2.4
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.3 0.5 0.9 -0.3 -1.1
Friendships satisfaction 0.5 0.7 1.0 -0.6 -0.8 -1.0 0.7
Qualifications: nursing, teaching 0.3 0.5 1.1 0.4 0.8 1.1 -0.2
Commuting to job workplace: Walk 2.1 2.2 5.3 -0.8 -0.6 -1.6 2.3
Eye problems/disorders: Cataract 5.8 6.7 11.6 2.7 1.5 2.4 -3.4
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.9 0.0 0.8 1.0 -0.3
Medication for cholesterol 0.9 1.3 1.9 1.4 1.2 -0.8 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.7 0.3 1.6 0.2 -1.1
Back pain experienced in last month 0.2 0.3 0.7 -0.5 -0.5 -0.8 -0.4
Mineral and other dietary supplements 0.7 1.0 1.2 -1.1 -0.9 -0.9 1.1
Breast cancer (self-reported) 2.1 2.5 3.7 1.9 1.2 1.9 -1.2
Asthma (self-reported) 0.5 1.0 1.9 1.4 1.3 0.3 -0.4
Osteoporosis (self-reported) 0.7 0.8 1.4 -0.4 1.2 0.9 -0.9
Osteoarthritis (self-reported) 0.7 0.9 1.6 -0.6 -1.2 -0.6 1.1
Medication: Aspirin 2.1 2.8 4.1 1.1 1.6 1.8 -2.0
Medication: Gliclazide 0.6 0.6 1.0 -0.1 1.0 0.9 -0.8
Illnesses of father: None of the above (group 1) 0.3 0.3 0.9 0.4 -0.4 -1.0 0.2
Smoking status: Current 0.8 1.3 1.7 1.3 1.3 0.9 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.5 5.3 7.5 -2.5 -2.2 -2.7 1.7
Whole body water mass 0.2 1.3 3.7 1.9 -0.1 0.8 -0.9
Leg predicted mass (right) 0.2 0.9 2.1 1.4 -0.6 1.0 -0.3
Arm fat mass (left) 0.3 1.1 2.2 1.5 0.1 0.9 -1.1
Number of self-reported non-cancer illnesses 0.3 0.5 1.0 -1.0 -0.5 -0.3 0.8
Average weekly champagne plus white wine intake 0.3 0.4 0.9 0.2 1.0 0.1 -0.8
Miserableness 0.0 0.1 0.2 0.1 0.2 -0.4 -0.4
Guilty feelings 0.5 0.8 1.6 0.4 0.7 -1.3 -1.0
Wears glasses or contact lenses 7.1 8.2 10.6 2.9 3.3 2.9 -2.2
Ever taken oral contraceptive pill 1.3 1.5 3.2 1.2 1.1 -0.2 -1.8
Hearing aid user 0.1 0.1 0.2 -0.4 -0.1 0.0 0.5
Mother’s age at death 0.1 0.1 0.2 0.3 -0.5 -0.4 -0.2
Financial situation satisfaction 1.1 1.4 3.0 -1.0 -1.7 -0.2 1.2
Tinnitus: Yes, now most or all of the time 2.0 2.4 4.1 -2.0 -1.4 -1.3 1.4
Commuting to job workplace: Public transport 0.5 0.6 1.3 -0.5 -1.1 -0.6 0.6
Eye problems/disorders: Glaucoma 3.3 3.9 5.8 1.2 2.4 1.7 -2.4
Medication: Blood pressure 0.9 1.8 2.4 -1.0 -1.5 1.5 1.2
Pain type(s) experienced in last month: Hip pain 1.9 2.4 5.1 0.6 2.3 1.1 -1.7
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.6 0.4 0.8 0.3 -0.6
High cholesterol (Self-reported) 0.0 0.1 0.2 -0.4 0.1 0.3 0.1
Medication: Bendroflumethiazide 1.2 1.9 5.6 -0.4 -1.0 2.4 0.9
Medication: Paracetamol 0.8 1.3 2.1 1.1 1.1 0.6 -1.5
Medication: Lisinopril 0.6 0.7 1.0 -1.0 -0.9 0.9 0.4
Medication: Atorvastatin 0.3 0.4 0.7 -0.8 -0.8 -0.3 0.5
Illnesses of father: High blood pressure 1.5 1.8 2.7 -1.6 -1.4 -0.9 1.3
Alcohol drinker status: Never 0.1 0.2 0.6 -0.8 -0.0 -0.2 -0.1
Ever smoked 0.3 0.4 1.7 0.2 0.1 -1.3 0.1
Basal metabolic rate 0.3 1.6 4.5 2.1 0.1 0.9 -1.0
Leg fat percentage (left) 0.1 0.4 1.1 0.6 0.2 0.3 -1.1
Arm fat-free mass (left) 0.2 1.0 3.0 1.7 -0.2 0.4 -0.8
Number of operations (self-reported) 0.6 0.8 1.2 -0.2 -1.0 -1.0 1.1
Average weekly beer plus cider intake 4.1 6.0 7.7 -2.3 -2.8 -2.7 1.9
Irritability 0.2 0.4 0.7 -0.8 -0.6 -0.7 0.4
Risk taking 0.3 0.4 1.7 0.1 0.3 1.3 0.2
Ever had prostate specific antigen (PSA) test 2.1 2.5 4.5 0.6 2.1 1.5 -1.6
Fractured/broken bones in last 5 years 0.1 0.2 0.2 -0.4 0.4 -0.3 -0.5
Age started oral contraceptive pill 3.1 3.9 6.4 1.5 1.7 2.5 -2.0
Diastolic blood pressure, automated reading 0.9 2.9 7.0 1.5 -0.7 2.6 -1.4
Ever depressed for a whole week 1.7 2.1 3.1 -1.6 -1.4 -0.9 1.8
Unable to work because of sickness or disability 3.0 3.9 6.6 -1.2 -2.6 -1.8 2.0
Commuting to job workplace: Cycle 0.3 0.3 0.8 -0.7 -0.0 -0.3 0.9
Myopia 0.0 0.1 0.1 0.3 -0.2 -0.1 0.3
Vascular/heart problems diagnosed by doctor 0.4 1.0 2.5 1.0 0.6 -1.6 0.2
Cholesterol lowering medication 0.7 1.1 2.4 -1.6 -0.8 -0.6 1.0
Medication: Omeprazole (e.g. Zanprol) 2.5 3.0 4.4 -1.7 -2.1 -1.4 1.6
Pain experienced in last month 0.0 0.0 0.1 0.0 0.1 0.2 0.3
Supplements: Calcium 1.6 1.7 3.0 1.0 1.0 1.7 -1.4
Basal cell carcinoma (self-reported) 0.1 0.1 0.5 0.2 -0.7 -0.2 0.1
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.8 -0.8 0.6 0.9 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 4.8 -2.2 -1.5 -1.2 0.7
Heart disease (siblings) 0.7 0.8 1.5 -1.1 -1.2 -0.0 0.7
Alcohol drinker status: Previous 0.2 0.2 0.4 -0.4 0.5 -0.2 -0.6
Pack years of smoking 1.0 1.4 3.5 0.9 0.7 1.0 -1.9
Impedance of whole body 4.0 20.4 33.0 4.6 5.7 4.0 -3.4
Leg fat mass (left) 0.3 1.1 2.0 1.4 0.1 0.8 -1.3
Arm predicted mass (left) 0.2 1.0 3.0 1.7 -0.1 0.4 -0.9