Hub : Genes

GPT

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.1810	0.0650	0.00069	0.037	NA	0.070	NA	0.059	0.02900	NA	4.2e-03	NA	8.0e-03
2	GTEx	Esophagus Mucosa	0.0810	0.0380	0.00400	0.019	NA	0.006	NA	0.017	0.01800	NA	1.3e-01	NA	2.5e-02
3	GTEx	Thyroid	0.0600	0.0290	0.00210	0.047	NA	0.054	NA	0.052	0.00017	NA	5.4e-05	NA	8.2e-05
4	YFS	Blood	0.0131	0.0058	0.00012	0.008	0.014	0.005	0.013	0.007	0.00085	1.4e-05	6.2e-03	2.9e-05	1.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.0	3.1	11.0	-3.3	-0.5	0.8	-0.7
Bipolar Disorder or Schizophrenia	1.1	2.7	7.7	-2.8	-1.0	1.3	-0.7
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	0.3	0.6	-0.5	0.6
Depression (Nagel 2018)	0.8	1.2	1.7	1.3	-1.3	1.2	-0.2
Intelligence (Savage-Jansen 2018)	7.9	24.3	37.7	-3.0	6.1	-5.6	4.4
Neuroticism (Nagel 2018)	0.2	0.6	0.9	0.8	-1.0	0.8	-0.3
Schizophrenia (2018)	0.3	0.6	0.8	-0.8	-0.9	0.9	-0.4
Schizophrenia vs Biploar Disorder	1.4	1.9	3.7	1.9	-1.3	1.1	-1.0
Worry (Nagel 2018)	0.1	0.2	0.4	-0.5	-0.4	0.6	-0.4
Alzheimer’s Disease (in mother)	2.3	2.7	3.7	-1.2	1.6	-1.8	1.9
Alzheimer’s Disease (in father)	0.6	0.7	2.3	-1.5	-0.3	0.3	0.5
Alzheimer’s Disease (including proxy)	0.8	1.2	3.3	-1.8	0.6	-0.6	0.9
Crohns Disease (2017)	1.2	2.6	6.4	-2.5	1.1	-1.0	1.3
Irritable Bowel Disease (IBD)	1.7	4.1	12.4	-3.5	1.4	-1.0	1.0
Ulcerative Colitis (UC)	1.4	2.6	9.1	-3.0	1.0	-0.5	0.4
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	6.9	13.1	18.6	2.3	-4.0	4.3	-3.6
Verbal and Numeric Reasoning (VNR)	5.4	12.9	21.4	-1.9	4.6	-4.3	2.9
Breast Cancer	0.4	1.0	1.5	-0.5	1.2	-1.1	1.0
Ovarian Cancer	0.0	0.0	0.0	0.1	0.1	-0.0	0.2
Prostate Cancer	2.9	4.1	5.4	1.8	-2.3	2.1	-1.8
Age at First Birth	6.9	10.0	15.8	-1.2	3.9	-4.0	2.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.5	-0.1	0.2	0.2
Coronary Artery Disease (CAD)	0.4	0.4	1.7	1.3	0.0	-0.2	0.0
Crohns Disease (2012)	2.6	4.2	7.5	-2.7	1.6	-1.2	2.3
Mean Putamen Volume	0.7	0.8	2.1	-1.4	0.8	-0.5	0.5
Fasting Glucose	1.0	1.2	2.4	-0.8	1.5	-1.4	0.2
HbA1C	0.8	0.9	1.5	0.2	0.9	-1.2	1.2
HDL Cholesterol	0.2	0.3	0.8	0.0	-0.6	0.9	-0.3
LDL Cholesterol	0.2	0.3	0.9	1.0	-0.2	0.3	-0.2
Lupus	0.1	0.1	0.2	0.3	0.4	-0.3	0.5
Neuroticism (2016)	0.3	0.4	0.7	-0.6	-0.8	0.8	-0.4
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.0	0.1	-0.5	0.4
Rheumatoid Arthritis	2.4	3.3	5.4	2.3	-1.5	1.0	-2.1
Schizophrenia (2014)	1.2	2.8	4.0	-0.9	-2.0	2.0	-1.5
Triglycerides	0.2	0.4	1.2	1.1	-0.4	-0.0	0.3
Type 2 Diabetes (T2D) (2012)	3.4	3.9	8.2	-2.0	1.3	-1.4	2.9
Ulcerative Colitis	2.1	3.0	8.6	-2.9	1.4	-0.9	0.8
Blood Eosinophil Count	0.1	0.6	2.4	-1.5	-0.3	-0.0	0.0
Blood Platelet Count	0.4	4.6	8.1	0.7	-2.8	2.7	-1.6
Blood Red Count	0.9	8.6	15.0	-1.0	3.6	-3.9	2.3
Blood White Count	0.1	0.9	2.0	-0.2	1.1	-1.4	0.7
Heel T-Score	0.3	2.7	10.3	-3.2	0.1	0.5	0.6
BMI	0.5	2.7	9.6	3.1	-0.4	-0.4	-0.9
Height	0.1	2.0	3.3	-1.1	1.4	-1.3	1.8
Waist Hip Ratio (WHR)	0.3	1.5	4.9	-2.2	0.7	-0.4	0.8
Systolic Blood Pressure	1.3	6.3	12.0	-0.4	3.0	-3.5	2.0
Smoking Status	4.2	10.1	17.3	-0.0	-4.1	4.2	-2.5
Allergy or Eczema	0.5	1.3	2.4	-0.5	1.5	-1.5	0.6
Cardiovascular Disease	3.7	12.3	17.6	-2.8	3.4	-3.5	4.2
Hypothyroidism (self reported)	0.3	0.8	1.9	-0.1	-0.6	0.9	-1.4
Respiratory disease	0.7	1.5	2.5	1.1	-1.0	1.2	-1.6
Type 2 Diabetes (T2D) (2018)	8.0	15.0	17.9	-3.1	4.1	-3.9	4.2
Lung FEV1/FVC ratio	0.1	0.4	1.1	-1.1	0.1	0.2	0.6
Lung FVC	5.5	27.8	48.6	7.0	-5.0	4.5	-4.1
Neuroticism	0.0	0.0	0.1	-0.1	-0.2	0.3	0.1
Chronotype (morning person)	0.4	0.9	2.4	-1.6	-0.8	0.7	0.2
Hair Pigment	0.1	2.6	3.1	-1.8	-1.5	1.4	-1.8
Tanning	0.0	0.1	0.3	0.1	-0.5	0.4	-0.2
Hand grip strength (left)	1.2	3.3	5.3	0.6	-2.1	2.3	-1.8
Number of treatments/medications taken	0.3	0.5	0.8	-0.7	0.9	-0.5	-0.5
Average weekly spirits intake	7.2	8.9	12.2	1.5	-3.3	3.5	-3.1
Sensitivity / hurt feelings	2.7	4.7	5.2	2.2	-2.1	2.3	-2.0
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.6	1.6	-1.4	1.5	-0.0
Hearing difficulty/problems: Yes	1.6	2.5	3.7	1.9	-1.5	1.0	-1.7
Relative age of first facial hair	0.3	0.6	2.1	-0.2	0.6	-0.3	1.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.9	1.0	0.4	-0.3	-0.3
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	0.0	0.5	-0.3	0.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.1	0.2	-0.1	0.6
Systolic blood pressure, automated reading	0.3	0.9	2.1	0.4	1.1	-1.4	-0.2
Eye problems/disorders: Diabetes related eye disease	3.5	3.8	5.9	-1.6	2.1	-1.6	2.4
Angina	1.0	1.3	4.7	-2.2	0.4	-0.5	0.4
Medication for hormone replacement therapy	0.4	0.5	1.5	0.0	0.4	-0.6	1.2
Vitamin and mineral supplements	2.2	3.0	4.3	1.5	-2.1	2.0	-1.2
Supplements: Zinc	0.6	0.7	1.3	1.1	-0.6	0.8	-0.7
Medication: Co-codamol	1.1	1.3	2.7	1.7	-0.9	0.6	-1.1
Medication: Metformin	2.7	3.8	4.7	-1.6	2.2	-2.1	1.9
Diabetes (father)	1.0	1.3	1.5	-1.1	1.1	-1.1	1.2
Diabetes (mother)	0.2	0.3	1.0	-1.0	0.0	0.3	-0.2
Severe depression (siblings)	3.2	3.5	6.2	1.3	-1.8	1.8	-2.5
Pack years adult smoking proportion	0.5	0.8	1.5	0.4	1.2	-1.2	0.3
Impedance of leg (right)	0.5	2.5	8.5	-2.9	-0.5	1.2	-0.2
Leg fat-free mass (left)	0.4	2.2	6.9	2.6	-0.9	0.2	-0.9
Trunk fat percentage	0.1	0.2	0.7	0.4	-0.3	-0.0	-0.9
Hand grip strength (right)	0.2	0.4	0.7	0.6	-0.6	0.8	-0.5
Townsend deprivation index at recruitment	0.1	0.2	0.2	0.2	-0.5	0.5	0.5
Current tobacco smoking	0.2	0.4	0.8	-0.1	-0.8	0.9	-0.0
Average weekly fortified wine intake	1.8	2.1	3.4	1.3	1.1	-1.8	1.6
Maternal smoking around birth	2.1	3.0	5.1	1.3	-2.3	1.9	-1.3
Fed-up feelings	0.6	1.2	2.1	1.4	-1.2	1.0	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.2	5.9	2.2	-2.4	2.2	-1.1
Relative age voice broke	0.5	0.8	1.6	0.1	-1.2	1.2	0.4
Taking other prescription medications	0.1	0.2	0.3	-0.5	0.6	-0.4	-0.4
Age when periods started (menarche)	0.3	0.7	2.2	-0.5	0.4	-0.6	1.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	0.1	1.1	-0.7	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.9	-0.4	-0.9	0.9	0.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	2.7	0.6	0.2	-0.2	-1.6
Qualifications: CSEs or equivalent	5.6	7.4	9.4	2.7	-3.1	2.9	-2.1
Serious illness, injury or assault to yourself	1.0	1.2	2.3	1.5	-1.0	0.8	-0.9
High blood pressure	1.4	3.9	5.6	-0.4	2.1	-2.4	2.3
Hayfever, allergic rhinitis or eczema	1.1	2.5	3.5	-1.0	1.8	-1.9	1.5
Multivitamins +/- minerals	3.3	4.1	6.4	-1.8	2.5	-2.5	1.0
Stomach or abdominal pain in last month	1.0	1.2	2.3	0.6	-1.4	1.5	-0.4
Supplements: Glucosamine	4.4	5.7	9.2	-1.4	3.0	-2.8	1.9
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.0	-0.6	0.6	-0.2	1.4
Medication: Atenolol	0.1	0.2	0.3	0.5	0.1	-0.2	-0.5
Medication: Levothyroxine sodium	0.2	0.4	1.0	-0.7	0.1	0.2	-1.0
Sitting height	0.0	0.2	0.3	-0.4	-0.5	0.4	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.4	0.7	-0.4	0.8	-0.6	0.6
High blood pressure (mother)	0.0	0.0	0.2	-0.1	-0.1	-0.1	0.4
Body mass index (BMI)	0.8	3.3	9.0	3.0	-1.1	0.4	-1.7
Impedance of leg (left)	0.4	2.1	7.7	-2.8	-0.2	0.9	0.2
Leg predicted mass (left)	0.4	2.4	7.4	2.7	-1.0	0.3	-1.0
Trunk fat mass	0.2	1.0	2.0	1.4	-0.7	0.1	-1.2
Waist circumference	0.1	0.3	0.9	0.9	0.1	-0.6	-0.2
Number of incorrect matches in round	0.3	0.4	0.8	-0.9	-0.2	0.7	-0.6
Past tobacco smoking	6.8	12.4	19.7	-0.3	4.2	-4.4	3.5
Alcohol usually taken with meals	0.8	1.3	2.3	-0.6	1.4	-1.5	0.7
Nervous feelings	0.0	0.0	0.1	0.1	-0.2	0.3	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	0.2	0.1	-0.2	0.8
Hearing difficulty/problems with background noise	3.3	5.3	7.4	1.9	-2.5	2.0	-2.7
Hair/balding pattern: Pattern 2	1.4	1.8	2.5	1.5	-1.6	1.5	-0.5
Had menopause	1.0	1.3	3.7	-1.9	1.0	-0.6	-0.2
Had other major operations	1.3	1.6	3.9	2.0	-1.1	0.9	-0.6
Forced vital capacity (FVC)	2.7	10.4	14.2	3.5	-3.8	3.5	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.3	-0.4	-0.4	0.5	1.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	4.9	2.2	-1.2	0.9	0.1
Qualifications: None of the above	2.9	6.2	9.1	1.4	-3.0	3.0	-2.3
Financial difficulties in last 2 years	1.5	2.0	4.5	2.1	-1.0	0.8	-1.4
Mouth/teeth dental problems	1.1	1.7	2.3	1.5	1.0	-1.5	1.2
Heart attack	0.2	0.2	0.5	-0.6	-0.2	0.3	0.7
Allergy	0.3	0.7	1.4	-0.4	-0.8	1.2	-0.7
Pain all over the body in last month	0.2	0.2	0.4	-0.1	0.6	-0.3	0.5
Diabetes (self-reported)	5.5	8.5	12.4	-1.7	3.5	-3.2	2.8
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	1.8	-0.9	1.3	-1.3	1.0
Medication: Ramipril	0.2	0.3	0.8	-0.2	0.4	-0.4	0.9
Medication: Simvastatin	0.8	1.2	2.5	-1.6	1.3	-0.6	0.6
Fluid intelligence score	6.8	14.2	20.4	-3.0	4.5	-4.0	3.4
Illnesses of siblings	1.9	2.7	5.4	-1.1	1.4	-1.4	2.3
Neuroticism score	0.6	1.2	1.8	1.3	-0.9	1.0	-1.0
Weight	0.5	2.3	6.3	2.5	-1.0	0.3	-1.3
Impedance of arm (right)	1.8	8.3	29.4	-5.4	0.8	0.0	1.7
Arm fat percentage (right)	0.1	0.5	1.0	0.5	-0.8	0.5	-1.0
Trunk fat-free mass	0.7	3.9	9.5	3.1	-1.6	0.9	-1.6
Hip circumference	0.1	0.4	1.1	1.0	0.1	-0.7	-0.1
Time employed in main current job	1.2	1.4	2.6	0.5	1.6	-1.6	0.4
Alcohol intake versus 10 years previously	0.4	0.5	1.1	-0.2	-1.0	1.1	-0.0
Father’s age at death	1.0	1.3	2.1	-0.6	1.4	-1.5	0.9
Worrier / anxious feelings	0.4	0.8	2.0	1.4	-0.6	0.3	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.0	1.4	0.3	-0.6	-0.0
Falls in the last year	2.0	2.7	4.4	2.1	-1.8	1.5	-1.0
Hair/balding pattern: Pattern 3	0.3	0.5	0.7	0.3	0.7	-0.8	0.8
Number of live births	5.2	7.3	11.8	0.4	-3.0	2.9	-3.4
Forced expiratory volume in 1-second (FEV1)	3.3	11.0	16.2	3.2	-4.0	3.8	-1.9
Pulse rate	0.1	0.2	0.5	0.7	0.2	-0.5	0.2
Happiness	1.2	1.5	1.8	1.1	-1.2	1.4	-1.1
Noisy workplace	0.6	0.7	1.4	1.0	-0.5	0.6	1.2
Qualifications: A levels/AS levels or equivalent	1.5	3.4	6.2	-0.9	2.3	-2.5	1.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.0	-1.4	1.0	-0.8	1.4
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	-0.2	0.2	0.2	-0.4
Asthma	0.1	0.3	0.4	0.1	-0.5	0.6	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.1	-0.2	0.4	-0.8
Medication: Cholesterol lowering	2.8	4.3	7.3	-2.7	2.1	-1.7	1.6
Depression (self-reported)	0.7	0.9	2.3	0.2	0.9	-0.6	1.5
Medication: Lansoprazole	0.5	0.6	0.8	0.6	-0.8	0.9	-0.7
Prospective memory result	0.6	0.8	1.3	0.7	-1.1	1.0	-0.5
Lung cancer (father)	0.5	0.5	0.8	0.9	-0.7	0.9	-0.3
Illnesses of mother	0.5	0.7	1.9	0.6	-0.5	0.5	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.6	12.5	3.5	-3.5	3.1	-2.0
Pulse wave Arterial Stiffness index	3.4	4.0	6.2	1.2	2.2	-2.5	1.8
Impedance of arm (left)	2.2	10.3	32.6	-5.7	1.4	-0.5	2.5
Arm fat mass (right)	0.4	1.6	2.8	1.7	-1.1	0.5	-1.4
Trunk predicted mass	0.7	4.1	9.8	3.1	-1.7	1.0	-1.6
Standing height	0.0	0.3	0.5	-0.7	0.2	-0.3	0.7
Length of working week for main job	1.2	1.4	4.4	0.3	0.7	-0.7	2.1
Exposure to tobacco smoke at home	2.4	2.7	4.6	2.1	-1.8	1.3	-1.1
Breastfed as a baby	0.1	0.1	0.4	0.6	-0.0	0.0	-0.4
Tense / ‘highly strung’	0.7	1.2	2.2	1.5	-0.8	0.4	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	4.6	1.5	-2.1	2.0	-0.9
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	0.1	0.8	-1.1	-0.4
Birth weight of first child	0.2	0.4	1.1	1.1	0.1	-0.2	0.6
Peak expiratory flow (PEF)	0.0	0.1	0.2	0.3	0.0	-0.2	0.5
Pulse wave reflection index	0.9	1.1	1.9	-0.2	1.4	-1.4	0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.9	0.6	0.8	-0.7	0.9
Loud music exposure frequency	3.2	3.5	9.3	3.1	-1.4	1.2	-1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.1	-0.9	1.0	-0.8	0.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.4	0.1	-1.4	1.6	-1.3
Blood clot in the leg (DVT)	0.4	0.5	1.0	1.0	0.7	-0.7	-0.1
Medication: Paracetamol	2.6	4.2	6.3	0.4	-2.1	2.5	-2.5
Headache pain in last month	0.5	0.8	1.5	0.0	-0.7	1.2	-1.2
Medication for cholesterol, blood pressure or diabetes	3.2	5.4	6.3	2.4	-2.5	2.2	-2.1
Glaucoma (self-reported)	0.8	1.0	1.6	-0.6	1.1	-0.9	1.3
Gout (self-reported)	0.7	1.0	1.6	0.8	-1.0	1.0	-1.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.2	-0.3	-0.4	0.6	-1.1
Medication: Amlodipine	0.8	1.1	1.5	-0.7	1.2	-1.1	1.0
Medication: Ventolin 100micrograms inhaler	1.7	2.1	5.1	2.3	-1.3	0.7	-1.2
Birth weight	0.3	0.6	1.2	-0.8	0.6	-0.4	1.1
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.9	0.3	-0.8	1.4	-0.9
High blood pressure (siblings)	0.3	0.4	0.7	-0.8	-0.4	0.5	-0.7
Forced vital capacity (FVC), Best measure	3.4	12.4	18.6	4.3	-3.9	3.4	-2.2
Body fat percentage	0.2	0.7	1.4	0.9	-0.6	0.2	-1.2
Leg fat percentage (right)	0.5	1.7	3.0	1.7	-0.9	0.4	-1.7
Arm fat-free mass (right)	0.9	4.4	13.5	3.7	-1.0	0.3	-1.7
Exposure to tobacco smoke outside home	0.9	1.2	2.2	1.5	0.8	-1.1	0.7
Comparative body size at age 10	0.2	0.6	2.0	1.4	0.0	-0.6	0.3
Number of full brothers	6.9	8.7	12.7	1.9	-3.6	3.5	-2.5
Worry too long after embarrassment	0.4	0.7	2.7	1.6	-0.2	-0.2	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	4.9	0.1	-2.1	2.2	-0.4
Wheeze or whistling in the chest in last year	0.2	0.4	1.0	0.1	-0.5	0.5	-1.0
Number of children fathered	1.3	1.5	2.1	0.6	-1.3	1.4	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.0	1.4	-1.2	1.2	-0.7
Age at first live birth	1.7	2.9	3.4	-1.8	1.8	-1.3	1.8
Pulse wave peak to peak time	2.9	3.4	5.2	-1.2	-2.0	2.3	-1.7
Health satisfaction	1.6	2.1	4.5	2.1	-1.0	0.8	-1.5
Shortness of breath walking on level ground	5.2	6.2	8.4	2.9	-2.6	2.5	-1.8
Qualifications: College or University degree	4.6	14.4	17.6	-2.6	4.2	-4.2	4.0
Eye problems/disorders: None of the above	1.4	1.7	2.8	1.2	-1.7	1.2	-1.0
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.3	0.1	-1.1	0.8	-1.2
Emphysema/chronic bronchitis	2.6	2.9	3.7	1.9	-1.8	1.5	-1.6
Medication for pain relief, constipation, heartburn	0.3	0.5	0.7	0.9	0.4	-0.8	0.7
Neck or shoulder pain in last month	0.9	1.2	2.0	0.1	1.4	-1.4	1.0
Medication: Blood pressure	0.5	0.9	0.9	-0.9	0.9	-0.9	1.0
Angina (self-reported)	0.7	0.9	3.3	-1.8	0.1	-0.3	0.1
Migraine (self-reported)	4.6	5.7	7.2	2.7	-2.3	2.1	-2.4
Medication: Ibuprofen	0.3	0.4	0.8	0.5	-0.3	0.5	-0.9
Medication: Allopurinol	0.3	0.3	1.1	1.0	-0.3	0.1	-0.4
Medication: Omeprazole	1.3	1.5	2.7	1.6	-0.9	0.8	-1.4
Medication: Seretide 50 evohaler	1.5	1.7	2.1	1.4	-1.2	1.2	-1.5
Mean time to correctly identify matches	4.8	9.1	12.0	2.2	-2.9	3.3	-3.5
Heart disease (mother)	0.2	0.2	0.7	-0.8	0.1	-0.2	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	3.7	-0.1	-1.7	1.9	-1.7
Whole body fat mass	0.3	1.4	3.2	1.8	-0.7	0.1	-1.3
Leg fat mass (right)	0.8	3.0	6.9	2.6	-1.1	0.5	-1.9
Arm predicted mass (right)	0.9	4.4	13.1	3.6	-1.0	0.3	-1.8
Pulse rate, automated reading	0.6	2.0	3.5	-0.2	1.4	-1.7	1.9
Alcohol intake frequency.	0.2	0.5	0.8	-0.8	-0.4	0.5	-0.9
Comparative height size at age 10	0.1	0.5	0.5	-0.7	-0.7	0.6	-0.7
Number of full sisters	5.6	6.8	9.1	1.9	-2.6	2.8	-3.0
Suffer from ‘nerves’	0.0	0.0	0.1	-0.1	0.3	0.1	0.1
Overall health rating	0.2	0.5	1.6	0.7	-0.2	0.1	-1.3
Chest pain or discomfort	0.1	0.2	0.4	-0.5	-0.2	0.3	-0.7
Had major operations	1.5	1.8	3.7	0.6	-1.8	1.9	-0.4
Age at last live birth	0.0	0.0	0.0	0.0	0.2	0.1	0.1
Family relationship satisfaction	1.9	2.4	3.9	0.9	-1.7	2.0	-1.4
Leg pain on walking	0.8	1.0	1.7	0.5	-1.3	1.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	6.4	7.7	11.4	3.4	-2.6	2.4	-2.6
Commuting to job workplace: Car/motor vehicle	1.7	1.9	2.3	1.2	-1.5	1.4	-1.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.2	0.2	-0.5	0.6
Medication: Aspirin	1.1	1.5	4.7	-2.2	0.8	-0.7	0.3
Supplements: Vitamin C	0.4	0.5	0.9	0.4	0.9	-0.7	0.7
Knee pain experienced in last month	1.1	1.7	4.4	1.1	-0.9	0.5	-2.1
Hypertension (Self-reported)	1.6	4.5	7.0	-0.5	2.3	-2.6	2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	2.5	0.6	-1.6	1.6	-1.3
Illnesses of father: Heart disease	0.1	0.2	0.3	-0.2	-0.6	0.4	-0.4
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.4	-0.4	0.4	-0.8
Smoking status: Previous	8.0	11.9	18.5	0.4	-4.0	4.3	-3.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.9	-0.2	-0.3	0.2	1.0
Whole body fat-free mass	0.7	3.8	10.5	3.2	-1.4	0.7	-1.4
Leg fat-free mass (right)	0.4	2.2	7.7	2.8	-0.7	0.0	-0.8
Arm fat percentage (left)	0.1	0.3	0.6	0.7	-0.6	0.2	-0.8
Average weekly red wine intake	1.7	2.5	4.3	0.4	1.5	-2.1	1.8
Handedness (chirality/laterality): Left-handed	3.8	4.6	5.5	2.3	-2.1	1.9	-2.2
Mood swings	1.0	1.8	5.9	2.4	-0.5	0.5	-0.7
Loneliness, isolation	0.4	0.6	1.5	-0.8	0.1	0.5	1.2
Long-standing illness, disability or infirmity	0.2	0.3	0.9	0.2	-0.2	0.4	-0.9
Ever had bowel cancer screening	2.7	3.1	5.1	-1.7	2.3	-1.7	1.2
Diabetes diagnosed by doctor	6.0	9.8	13.9	-2.3	3.7	-3.3	3.0
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.2	0.3	-1.8	1.6	-1.0
Friendships satisfaction	0.1	0.1	0.2	0.4	0.4	-0.1	-0.1
Qualifications: nursing, teaching	1.2	1.8	2.7	-1.2	1.6	-1.5	1.1
Commuting to job workplace: Walk	2.3	2.4	7.6	-2.7	1.1	-0.9	0.4
Eye problems/disorders: Cataract	0.8	1.0	1.7	-0.4	-0.9	1.1	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	5.6	-2.4	0.8	-0.5	0.2
Medication for cholesterol	0.3	0.5	1.2	0.5	-0.7	0.4	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.0	4.7	7.2	0.7	-2.4	2.7	-2.4
Back pain experienced in last month	0.1	0.2	0.5	0.2	-0.2	-0.1	-0.7
Mineral and other dietary supplements	5.5	7.4	11.7	1.8	-3.4	3.4	-1.8
Breast cancer (self-reported)	0.3	0.3	0.7	0.2	-0.6	0.5	-0.8
Asthma (self-reported)	0.2	0.5	0.7	0.1	-0.8	0.9	-0.8
Osteoporosis (self-reported)	3.7	4.6	9.2	-3.0	2.0	-1.6	1.5
Osteoarthritis (self-reported)	1.0	1.2	1.8	1.3	-0.9	1.0	-1.2
Medication: Aspirin	1.3	1.8	4.9	-2.2	1.0	-0.9	0.4
Medication: Gliclazide	1.3	1.4	2.4	-1.5	1.2	-1.0	1.0
Illnesses of father: None of the above (group 1)	1.7	2.1	4.7	2.2	-1.3	1.0	-1.0
Smoking status: Current	0.1	0.2	0.3	-0.6	-0.3	0.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.1	6.5	9.7	3.1	-2.4	2.3	-2.4
Whole body water mass	0.7	3.8	10.8	3.3	-1.4	0.7	-1.5
Leg predicted mass (right)	0.4	2.1	7.5	2.7	-0.7	-0.0	-0.7
Arm fat mass (left)	0.3	1.4	3.4	1.9	-0.8	0.3	-1.2
Number of self-reported non-cancer illnesses	0.3	0.5	0.9	0.5	0.9	-0.9	0.4
Average weekly champagne plus white wine intake	0.3	0.4	1.0	-1.0	0.1	-0.5	0.6
Miserableness	0.3	0.5	0.9	0.3	0.7	-1.0	0.6
Guilty feelings	1.8	2.7	8.8	3.0	-1.1	0.9	-0.3
Wears glasses or contact lenses	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.3
Ever taken oral contraceptive pill	2.2	2.5	4.1	1.2	-2.0	1.7	-1.2
Hearing aid user	0.5	0.6	1.1	-1.0	-0.6	1.0	-0.0
Mother’s age at death	0.2	0.3	1.0	1.0	-0.2	-0.2	-0.4
Financial situation satisfaction	4.7	5.8	7.1	2.6	-2.7	2.4	-1.9
Tinnitus: Yes, now most or all of the time	2.3	2.7	3.6	1.5	-1.6	1.6	-1.9
Commuting to job workplace: Public transport	0.9	1.1	1.9	-0.1	1.3	-1.4	0.8
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.2	0.7	-0.4	-0.0
Medication: Blood pressure	1.0	1.9	3.0	-0.8	1.7	-1.5	1.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	-0.7	0.4	-0.7	-0.1
Supplements: Fish oil (including cod liver oil)	1.9	2.5	4.7	-2.2	1.5	-1.5	0.8
High cholesterol (Self-reported)	0.3	0.5	1.6	-1.3	0.2	0.4	-0.4
Medication: Bendroflumethiazide	2.4	3.7	5.1	-0.8	2.2	-2.1	2.2
Medication: Paracetamol	1.1	1.7	2.4	0.3	-1.4	1.5	-1.6
Medication: Lisinopril	1.3	1.7	2.2	-1.4	1.1	-1.2	1.5
Medication: Atorvastatin	0.3	0.3	0.8	-0.3	0.6	-0.4	0.9
Illnesses of father: High blood pressure	1.0	1.2	2.8	0.2	1.7	-1.2	0.6
Alcohol drinker status: Never	0.4	0.5	1.7	-0.4	0.2	-0.4	-1.3
Ever smoked	4.3	7.5	11.9	0.8	-3.5	3.4	-2.5
Basal metabolic rate	0.7	3.8	10.2	3.2	-1.4	0.7	-1.5
Leg fat percentage (left)	0.4	1.5	3.7	1.9	-0.7	0.1	-1.4
Arm fat-free mass (left)	1.1	5.4	15.1	3.9	-1.5	0.7	-1.9
Number of operations (self-reported)	1.3	1.9	3.4	1.0	-1.7	1.8	-0.7
Average weekly beer plus cider intake	3.8	5.5	8.0	2.8	-2.0	2.2	-2.2
Irritability	0.6	1.0	1.5	0.7	-0.9	1.1	-1.2
Risk taking	0.1	0.1	0.2	-0.3	0.4	-0.1	0.3
Ever had prostate specific antigen (PSA) test	4.2	4.9	6.9	-2.6	2.2	-2.0	1.9
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-0.8	0.3	-0.6	1.2
Age started oral contraceptive pill	2.4	3.0	4.6	-1.6	2.2	-1.8	1.2
Diastolic blood pressure, automated reading	0.5	1.7	4.8	2.2	0.3	-0.9	-0.9
Ever depressed for a whole week	1.6	1.9	3.4	0.9	-1.8	1.8	-0.6
Unable to work because of sickness or disability	2.8	3.6	7.4	2.7	-1.5	1.1	-1.9
Commuting to job workplace: Cycle	4.0	4.8	8.0	-0.8	2.3	-2.3	2.8
Myopia	1.1	1.6	5.9	2.4	-0.4	-0.1	-0.5
Vascular/heart problems diagnosed by doctor	1.1	2.9	4.1	0.7	-1.8	2.0	-2.0
Cholesterol lowering medication	0.0	0.1	0.2	-0.0	0.2	0.4	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.4	1.5	-0.3	0.3	-0.8
Pain experienced in last month	0.6	1.0	2.1	0.3	-1.4	1.3	-0.3
Supplements: Calcium	1.8	2.0	3.6	-0.8	1.9	-1.7	0.9
Basal cell carcinoma (self-reported)	0.6	0.8	1.2	1.1	-0.8	0.5	-1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	-0.5	-0.5	0.6	0.3
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.7	0.8	0.8	-0.7	0.0
Heart disease (siblings)	0.5	0.6	1.2	1.0	-0.2	0.2	-1.1
Alcohol drinker status: Previous	1.0	1.2	1.7	-0.9	1.1	-1.1	1.3
Pack years of smoking	0.5	0.7	1.4	0.5	1.0	-1.2	0.1
Impedance of whole body	1.5	7.5	25.6	-5.1	1.1	-0.2	1.7
Leg fat mass (left)	0.8	2.9	7.6	2.8	-1.0	0.4	-1.8
Arm predicted mass (left)	1.1	5.8	14.9	3.9	-1.7	0.9	-2.1