Hub : Genes

NFIL3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0740	0.0290	0.0020	0.063	0.01	0.047	0.060	0.053	3.7e-08	0.01900	2.0e-06	8.4e-08	4.9e-07
2	GTEx	Testis	0.4670	0.0910	0.0012	0.330	NA	0.286	NA	0.044	2.9e-15	NA	3.8e-13	NA	5.1e-03
3	YFS	Blood	0.0234	0.0092	0.0021	0.005	0.01	0.011	0.011	0.008	5.9e-03	0.00029	1.4e-04	1.5e-04	8.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.2	0.3	0.4	-0.4	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	0.9	0.2	0.0
Depressed Affect (Nagel 2018)	1.7	3.6	5.9	-1.9	2.4	-1.1
Depression (Nagel 2018)	0.2	0.3	0.5	-0.6	0.2	0.7
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.5	0.1	-1.2	-1.9
Neuroticism (Nagel 2018)	0.9	2.2	4.6	-1.1	2.1	-1.0
Schizophrenia (2018)	0.2	0.4	0.6	0.8	0.6	0.4
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	0.7	0.1	0.1
Worry (Nagel 2018)	0.0	0.1	0.3	-0.0	-0.0	0.5
Alzheimer’s Disease (in mother)	0.5	0.5	0.8	-0.8	0.9	-0.3
Alzheimer’s Disease (in father)	1.0	1.1	1.3	-1.1	1.1	-0.9
Alzheimer’s Disease (including proxy)	0.6	0.8	1.1	-1.0	1.1	-0.6
Crohns Disease (2017)	0.6	1.2	2.9	-1.7	0.8	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.1	0.7	0.0
Ulcerative Colitis (UC)	0.4	0.8	1.8	0.7	-0.2	1.4
Major Depression (MDD)	0.2	0.3	0.7	0.1	0.8	-0.4
Reaction Time	0.5	1.0	1.6	1.3	-1.2	0.3
Verbal and Numeric Reasoning (VNR)	1.1	2.5	4.3	0.8	-2.1	-1.6
Breast Cancer	3.6	8.7	14.5	-0.2	3.4	-3.8
Ovarian Cancer	0.7	0.9	1.5	-0.9	0.7	-1.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.7	1.1	2.3	1.5	-0.3	-0.9
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.0	0.6	0.4
Body Mass Index (BMI) (2010)	1.0	1.4	2.5	-1.6	1.3	0.1
Coronary Artery Disease (CAD)	0.2	0.3	0.7	-0.2	-0.8	0.3
Crohns Disease (2012)	0.2	0.3	0.8	0.0	0.9	-0.4
Mean Putamen Volume	1.0	1.2	2.9	-0.2	-1.7	0.8
Fasting Glucose	0.5	0.6	1.0	-0.8	-1.0	0.1
HbA1C	0.2	0.2	0.6	0.2	-0.0	-0.8
HDL Cholesterol	0.1	0.2	0.3	0.3	-0.5	0.6
LDL Cholesterol	0.8	1.2	3.2	-1.8	0.1	-0.7
Lupus	0.1	0.2	0.6	-0.2	0.8	-0.2
Neuroticism (2016)	1.2	1.7	4.9	-2.2	-0.3	-0.2
Primary Biliary Cirrhosis	0.7	1.0	2.1	0.2	-0.9	1.4
Rheumatoid Arthritis	0.7	0.9	1.2	-1.1	-0.7	-1.1
Schizophrenia (2014)	0.2	0.4	0.5	0.7	0.3	0.7
Triglycerides	0.2	0.3	0.8	0.9	-0.3	0.2
Type 2 Diabetes (T2D) (2012)	1.2	1.4	1.7	-1.3	-1.0	1.3
Ulcerative Colitis	1.6	2.4	4.8	1.5	-0.2	2.2
Blood Eosinophil Count	1.7	13.0	29.7	-2.9	1.1	5.5
Blood Platelet Count	0.1	0.6	1.2	1.1	0.0	-0.8
Blood Red Count	0.3	2.9	8.2	-0.8	2.9	-0.0
Blood White Count	0.7	4.8	13.6	3.7	0.9	0.2
Heel T-Score	0.1	1.0	1.7	-1.1	0.4	-1.3
BMI	2.2	12.6	35.6	-0.9	6.0	-1.1
Height	0.8	15.0	29.7	-3.9	5.5	0.1
Waist Hip Ratio (WHR)	2.4	10.8	18.4	-2.6	2.6	-4.3
Systolic Blood Pressure	0.1	0.6	1.5	-0.5	0.5	1.2
Smoking Status	1.2	2.9	5.8	-1.6	-0.3	2.4
Allergy or Eczema	2.5	6.5	13.0	-2.1	-1.4	-3.6
Cardiovascular Disease	1.4	4.7	12.4	-0.8	3.5	-1.0
Hypothyroidism (self reported)	0.6	1.4	2.6	0.5	-1.2	1.6
Respiratory disease	0.5	1.2	2.7	-1.6	0.3	0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.8	-0.4	1.3	-0.2
Lung FEV1/FVC ratio	0.1	0.7	2.1	0.1	1.4	-0.1
Lung FVC	1.4	6.9	11.3	2.8	-3.4	-1.3
Neuroticism	0.4	0.9	1.5	-1.1	1.2	-0.2
Chronotype (morning person)	1.0	2.4	6.4	2.5	-0.3	-0.8
Hair Pigment	0.2	6.0	14.2	-1.6	3.8	-1.1
Tanning	0.1	1.4	1.8	1.4	0.8	1.3
Hand grip strength (left)	0.3	0.8	2.2	0.0	-0.2	-1.5
Number of treatments/medications taken	0.7	1.3	3.7	-0.4	1.9	-0.4
Average weekly spirits intake	0.9	1.1	2.3	-1.5	-0.9	0.4
Sensitivity / hurt feelings	0.2	0.4	0.7	-0.6	0.4	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	-0.3	0.8	0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.0	0.9	-0.4
Relative age of first facial hair	1.7	3.4	6.7	-1.5	2.6	-1.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.4	-1.2	0.7	-0.3
Ever used hormone-replacement therapy (HRT)	1.3	1.6	3.5	0.3	-1.1	1.9
Ever had hysterectomy (womb removed)	1.3	1.4	2.4	-1.5	1.4	-0.4
Systolic blood pressure, automated reading	0.3	1.0	2.6	0.5	-0.4	1.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.6	-1.0	-0.1	-1.3
Angina	0.4	0.5	0.9	-1.0	0.6	-0.6
Medication for hormone replacement therapy	0.5	0.6	1.0	-0.8	1.0	-0.3
Vitamin and mineral supplements	0.9	1.2	2.7	-1.6	-0.3	0.9
Supplements: Zinc	0.3	0.3	0.7	-0.9	0.3	-0.4
Medication: Co-codamol	1.0	1.2	3.5	1.9	0.2	0.2
Medication: Metformin	0.8	1.1	2.1	-1.5	1.0	0.1
Diabetes (father)	2.7	3.4	7.6	0.6	-1.5	2.8
Diabetes (mother)	0.8	1.0	2.8	-0.3	-0.6	1.7
Severe depression (siblings)	0.2	0.2	0.5	0.2	0.3	-0.7
Pack years adult smoking proportion	0.8	1.2	3.1	-1.8	0.4	0.4
Impedance of leg (right)	1.5	7.0	20.0	-0.5	-4.5	1.0
Leg fat-free mass (left)	2.8	14.6	40.9	-1.5	6.4	-1.0
Trunk fat percentage	1.5	5.9	16.7	-0.7	4.1	-0.7
Hand grip strength (right)	0.3	0.8	1.8	0.8	-0.3	-1.3
Townsend deprivation index at recruitment	1.0	1.3	3.3	-0.8	-0.0	1.8
Current tobacco smoking	1.3	2.1	5.7	0.7	0.2	2.4
Average weekly fortified wine intake	1.3	1.5	2.3	1.5	-1.1	0.9
Maternal smoking around birth	0.2	0.3	0.8	-0.3	-0.3	-0.9
Fed-up feelings	1.1	2.0	3.9	-2.0	1.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.7	4.7	-2.2	1.5	1.1
Relative age voice broke	0.5	0.8	1.4	-1.2	1.0	0.0
Taking other prescription medications	0.4	0.5	0.9	-0.2	-1.0	0.8
Age when periods started (menarche)	0.2	0.5	0.7	0.8	-0.9	-0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	-0.7	0.5	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	4.1	-0.7	0.7	-2.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.2	0.3	1.1	0.9
Qualifications: CSEs or equivalent	1.8	2.4	2.9	-1.7	1.4	1.5
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.2	0.5	0.7
High blood pressure	0.9	2.6	6.0	-0.3	2.4	1.3
Hayfever, allergic rhinitis or eczema	3.2	6.9	14.1	-2.1	-1.4	-3.8
Multivitamins +/- minerals	1.2	1.6	4.1	0.8	-0.3	-2.0
Stomach or abdominal pain in last month	0.9	1.1	3.2	-1.8	0.0	-0.3
Supplements: Glucosamine	0.3	0.4	0.8	0.9	0.6	0.3
Diverticular disease/diverticulitis (self-reported)	2.5	2.9	5.2	2.3	-1.6	1.1
Medication: Atenolol	0.7	0.9	1.9	-0.7	0.7	-1.4
Medication: Levothyroxine sodium	0.2	0.3	0.6	0.5	-0.8	0.4
Sitting height	0.7	5.2	8.8	-3.0	2.3	1.3
Chronic bronchitis/emphysema (father)	1.1	1.3	2.5	0.0	-1.6	1.1
High blood pressure (mother)	0.3	0.4	0.9	0.3	-0.9	0.6
Body mass index (BMI)	2.9	12.3	32.5	-0.0	5.7	-2.1
Impedance of leg (left)	1.6	7.7	20.0	-0.5	-4.5	1.7
Leg predicted mass (left)	2.8	14.8	41.5	-1.5	6.4	-0.9
Trunk fat mass	2.7	11.4	32.0	-1.0	5.7	-1.2
Waist circumference	3.5	12.8	34.6	-0.8	5.9	-1.8
Number of incorrect matches in round	0.6	1.0	2.0	0.8	1.4	0.5
Past tobacco smoking	0.5	1.0	1.8	1.3	0.5	-0.9
Alcohol usually taken with meals	0.4	0.7	1.6	-0.4	1.3	-0.6
Nervous feelings	0.2	0.5	0.8	-0.1	-0.9	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	0.4	1.2	-0.5
Hearing difficulty/problems with background noise	0.8	1.2	2.3	-0.5	1.0	-1.5
Hair/balding pattern: Pattern 2	0.8	1.1	2.0	-0.8	0.8	-1.4
Had menopause	0.6	0.7	1.6	0.6	0.6	1.2
Had other major operations	2.4	3.0	7.7	0.1	-1.1	2.8
Forced vital capacity (FVC)	0.2	0.7	1.7	-0.2	-0.6	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	2.1	0.1	0.5	-1.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.8	-1.3	0.3	1.1
Qualifications: None of the above	1.4	3.0	4.7	0.6	2.0	-2.2
Financial difficulties in last 2 years	1.7	2.3	4.6	-1.5	2.1	0.2
Mouth/teeth dental problems	0.2	0.3	0.4	0.3	-0.5	-0.7
Heart attack	0.4	0.6	1.1	-0.3	0.7	1.0
Allergy	1.1	2.5	4.2	1.5	1.0	2.1
Pain all over the body in last month	0.2	0.2	0.7	0.8	-0.2	0.1
Diabetes (self-reported)	0.3	0.5	1.1	-0.4	1.0	-0.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.5	-0.0	-1.9	-0.3
Medication: Ramipril	1.5	1.9	2.2	-1.5	1.2	1.4
Medication: Simvastatin	1.1	1.7	2.8	0.2	1.7	-1.5
Fluid intelligence score	1.0	2.1	5.1	1.0	-2.3	-0.2
Illnesses of siblings	0.6	0.9	2.6	-0.3	0.1	-1.6
Neuroticism score	0.9	1.8	2.6	-1.4	1.6	-0.9
Weight	3.3	16.3	46.4	-1.2	6.8	-1.1
Impedance of arm (right)	2.3	10.6	26.5	-1.2	-5.1	1.9
Arm fat percentage (right)	1.7	6.6	17.5	-0.2	4.2	-1.5
Trunk fat-free mass	2.0	11.5	33.1	-0.9	5.8	-0.7
Hip circumference	1.9	8.1	23.9	0.2	4.9	0.5
Time employed in main current job	0.7	0.8	1.1	1.0	0.6	-1.0
Alcohol intake versus 10 years previously	1.0	1.5	2.9	1.7	0.3	1.3
Father’s age at death	0.3	0.5	1.0	-0.1	-1.0	0.6
Worrier / anxious feelings	0.2	0.4	0.5	-0.7	0.6	-0.5
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	8.2	-2.9	0.7	1.0
Falls in the last year	0.3	0.4	1.2	1.1	-0.2	-0.1
Hair/balding pattern: Pattern 3	1.4	2.1	3.0	1.4	-1.1	1.7
Number of live births	2.2	3.1	5.4	-1.9	2.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.5	-0.1	-0.4	-1.6
Pulse rate	1.3	2.2	4.4	-0.9	-1.1	2.1
Happiness	0.5	0.5	1.6	-1.3	-0.1	-0.0
Noisy workplace	0.4	0.5	0.9	0.8	0.9	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	0.7	-0.4	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	-0.3	-0.8	-0.6
Mouth/teeth dental problems: Dentures	0.9	1.5	3.6	1.9	0.8	0.4
Asthma	0.6	1.1	3.3	-1.8	0.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.1	1.1	0.7	-1.1
Medication: Cholesterol lowering	0.9	1.4	3.1	0.2	1.7	-1.0
Depression (self-reported)	1.2	1.4	2.8	1.1	0.4	-1.7
Medication: Lansoprazole	0.2	0.2	0.5	0.4	-0.1	0.7
Prospective memory result	1.0	1.2	3.5	0.4	1.9	0.3
Lung cancer (father)	0.1	0.2	0.2	-0.5	0.5	0.2
Illnesses of mother	1.0	1.3	2.4	-1.2	1.6	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.2	0.8	-0.3	-1.1
Pulse wave Arterial Stiffness index	1.1	1.3	3.6	0.3	0.4	1.9
Impedance of arm (left)	2.0	9.1	22.7	-0.9	-4.8	1.9
Arm fat mass (right)	2.9	12.1	32.4	-1.0	5.7	-1.7
Trunk predicted mass	1.9	11.1	31.9	-0.9	5.7	-0.7
Standing height	0.7	7.0	11.1	-2.8	3.3	1.5
Length of working week for main job	4.3	4.7	7.5	-2.7	2.4	-1.0
Exposure to tobacco smoke at home	0.2	0.2	0.4	-0.7	0.4	-0.3
Breastfed as a baby	0.4	0.5	1.0	-0.8	1.0	-0.1
Tense / ‘highly strung’	0.4	0.6	1.1	-0.4	-0.7	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.8	0.2	1.4	-0.7
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	-0.4	-0.1	-0.3
Birth weight of first child	1.8	3.3	6.9	-2.6	1.6	-0.7
Peak expiratory flow (PEF)	0.4	0.9	1.7	-0.0	-1.3	-1.0
Pulse wave reflection index	0.9	1.1	2.3	1.5	-0.7	0.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.2	-1.0	1.1	-0.1
Loud music exposure frequency	0.2	0.2	0.3	-0.2	-0.4	-0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.0	1.0	-0.6	-0.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.7	-1.6	1.3	-0.7
Blood clot in the leg (DVT)	0.2	0.3	0.7	-0.4	-0.8	0.2
Medication: Paracetamol	1.6	2.7	5.5	0.2	2.4	-1.6
Headache pain in last month	0.4	0.6	1.7	0.1	1.3	-0.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.9	0.1	-2.2	0.3
Glaucoma (self-reported)	1.7	2.0	3.9	2.0	1.1	-0.8
Gout (self-reported)	0.2	0.3	0.5	0.6	-0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.3	0.8	-1.1	0.9
Medication: Amlodipine	0.7	0.9	1.7	-1.3	0.2	1.0
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.4	-1.8	-0.3	0.2
Birth weight	0.2	0.5	1.4	-1.2	0.1	0.0
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.0	0.0	-1.4	-1.2
High blood pressure (siblings)	0.5	0.7	2.0	0.4	-0.3	1.4
Forced vital capacity (FVC), Best measure	0.2	0.6	1.0	0.8	-1.0	-0.5
Body fat percentage	1.6	6.4	18.2	-0.2	4.3	-1.0
Leg fat percentage (right)	1.8	6.5	14.9	0.8	3.9	-2.0
Arm fat-free mass (right)	2.6	13.5	39.3	-1.0	6.3	-0.5
Exposure to tobacco smoke outside home	1.5	2.0	5.5	-2.3	0.8	-0.2
Comparative body size at age 10	1.3	3.7	7.3	-1.7	1.0	-2.7
Number of full brothers	0.1	0.1	0.2	0.4	-0.4	0.3
Worry too long after embarrassment	0.7	1.2	2.0	0.1	1.3	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	2.6	-1.6	1.3	-0.6
Wheeze or whistling in the chest in last year	2.0	3.5	5.9	-2.4	2.0	0.8
Number of children fathered	1.7	1.9	4.9	0.1	1.0	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	1.5	0.5	0.7	-1.2
Age at first live birth	0.8	1.4	2.3	1.5	-1.3	-0.4
Pulse wave peak to peak time	0.9	1.1	3.1	-0.5	-0.2	-1.8
Health satisfaction	2.6	3.3	8.8	-3.0	0.4	1.0
Shortness of breath walking on level ground	1.9	2.3	3.5	-1.8	0.1	1.9
Qualifications: College or University degree	1.2	3.8	9.2	-0.8	-3.0	1.3
Eye problems/disorders: None of the above	0.4	0.5	0.9	0.4	0.7	-1.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.9	-0.9	0.3	-0.9
Emphysema/chronic bronchitis	0.6	0.6	1.6	-0.1	0.5	1.3
Medication for pain relief, constipation, heartburn	0.7	1.2	2.2	-0.8	-1.5	0.8
Neck or shoulder pain in last month	0.8	1.1	1.9	1.0	-0.7	1.4
Medication: Blood pressure	1.0	1.7	4.1	0.3	2.0	1.0
Angina (self-reported)	0.3	0.4	0.8	-0.9	0.3	-0.6
Migraine (self-reported)	0.8	1.0	2.1	-0.6	-1.4	-0.7
Medication: Ibuprofen	0.9	1.1	1.2	1.1	1.0	-1.0
Medication: Allopurinol	0.3	0.4	1.0	0.4	-1.0	0.2
Medication: Omeprazole	1.4	1.6	4.8	-2.2	0.2	0.1
Medication: Seretide 50 evohaler	0.4	0.4	1.0	-1.0	-0.5	-0.3
Mean time to correctly identify matches	1.7	3.2	4.9	2.2	-2.2	0.2
Heart disease (mother)	1.1	1.4	2.8	1.0	-1.7	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.1	-0.8	-1.5	0.5
Whole body fat mass	2.9	12.2	33.6	-0.7	5.8	-1.6
Leg fat mass (right)	3.1	12.2	32.7	-0.3	5.7	-1.9
Arm predicted mass (right)	2.9	15.0	43.2	-1.2	6.6	-0.6
Pulse rate, automated reading	0.1	0.2	0.5	-0.1	0.3	0.7
Alcohol intake frequency.	0.5	1.2	2.7	1.0	1.6	-0.3
Comparative height size at age 10	0.6	3.5	7.6	-1.6	2.7	0.5
Number of full sisters	1.3	1.6	4.1	0.6	-0.7	2.0
Suffer from ‘nerves’	0.2	0.3	0.6	0.7	-0.4	-0.4
Overall health rating	1.2	2.6	4.5	-1.4	2.1	1.1
Chest pain or discomfort	1.8	2.5	6.7	-2.6	0.4	0.9
Had major operations	1.1	1.3	1.9	-1.4	-0.3	-1.4
Age at last live birth	0.9	1.4	2.7	1.6	-0.9	-0.7
Family relationship satisfaction	1.4	1.7	4.4	-2.1	0.8	0.1
Leg pain on walking	3.2	4.0	10.8	-1.1	3.3	-0.3
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	5.0	-0.8	1.0	2.2
Commuting to job workplace: Car/motor vehicle	2.7	3.1	7.2	-1.2	2.7	-0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.2	0.7	-1.1	-0.7
Medication: Aspirin	1.0	1.3	3.8	0.2	2.0	-0.4
Supplements: Vitamin C	0.9	1.1	1.7	-0.8	0.9	1.3
Knee pain experienced in last month	0.9	1.4	3.7	0.3	1.9	0.6
Hypertension (Self-reported)	0.8	2.3	6.2	-0.6	2.5	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	4.0	1.2	-2.0	1.6
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.7	0.1	0.8
Illnesses of siblings: Diabetes	0.3	0.4	0.7	0.8	0.7	0.2
Smoking status: Previous	0.5	0.7	2.0	-1.4	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	4.2	-1.9	2.0	1.1
Whole body fat-free mass	2.4	13.7	39.1	-1.3	6.3	-0.5
Leg fat-free mass (right)	2.5	13.3	37.6	-1.5	6.1	-0.4
Arm fat percentage (left)	1.8	7.4	19.9	-0.2	4.5	-1.5
Average weekly red wine intake	0.3	0.4	0.8	0.9	-0.5	0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.4	0.2	-0.8
Mood swings	1.3	2.3	3.4	-1.2	1.9	-1.4
Loneliness, isolation	0.6	0.8	1.1	-1.0	0.7	1.1
Long-standing illness, disability or infirmity	0.4	0.6	1.3	0.6	1.1	-0.1
Ever had bowel cancer screening	0.9	1.1	1.6	1.1	-1.3	0.6
Diabetes diagnosed by doctor	0.2	0.3	0.9	0.1	1.0	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.5	0.7	-0.8	1.2
Friendships satisfaction	0.2	0.2	0.4	-0.7	-0.3	-0.2
Qualifications: nursing, teaching	0.0	0.1	0.2	0.1	-0.4	-0.0
Commuting to job workplace: Walk	1.1	1.1	2.2	0.4	-1.5	1.0
Eye problems/disorders: Cataract	2.0	2.4	6.7	-0.2	-2.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	1.7	-1.2	-1.3	-0.1
Medication for cholesterol	0.7	1.1	1.5	1.2	-0.7	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	3.4	1.9	-0.8	-0.4
Back pain experienced in last month	1.9	2.7	5.9	0.4	2.4	-1.5
Mineral and other dietary supplements	0.5	0.7	1.7	-1.3	-0.3	0.6
Breast cancer (self-reported)	0.2	0.2	0.3	0.4	0.3	0.6
Asthma (self-reported)	0.7	1.4	4.0	-2.0	0.1	-0.1
Osteoporosis (self-reported)	0.2	0.2	0.5	0.2	-0.3	-0.7
Osteoarthritis (self-reported)	1.0	1.3	2.7	1.0	1.7	0.4
Medication: Aspirin	1.1	1.4	3.3	0.5	1.8	-0.8
Medication: Gliclazide	0.1	0.1	0.1	-0.4	0.2	0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	1.8	0.2	-0.2	-1.3
Smoking status: Current	1.5	2.5	6.9	0.6	0.3	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	6.6	2.6	-0.7	-0.8
Whole body water mass	2.3	13.3	38.4	-1.1	6.2	-0.6
Leg predicted mass (right)	2.5	13.3	37.6	-1.4	6.1	-0.4
Arm fat mass (left)	2.9	12.1	33.2	-0.6	5.8	-1.7
Number of self-reported non-cancer illnesses	0.4	0.6	0.9	0.9	0.4	0.9
Average weekly champagne plus white wine intake	1.0	1.4	3.1	-0.5	0.9	-1.7
Miserableness	2.2	3.9	4.9	-2.2	2.0	-1.6
Guilty feelings	0.6	0.9	1.7	0.3	0.9	-1.3
Wears glasses or contact lenses	0.3	0.3	0.6	-0.6	-0.8	0.0
Ever taken oral contraceptive pill	1.0	1.1	2.2	-1.5	0.9	-0.7
Hearing aid user	1.1	1.2	3.1	1.7	0.7	0.2
Mother’s age at death	0.5	0.6	1.7	0.3	-1.3	-0.3
Financial situation satisfaction	0.7	0.8	2.0	-1.4	0.7	0.2
Tinnitus: Yes, now most or all of the time	3.3	3.8	6.0	2.5	-2.2	0.8
Commuting to job workplace: Public transport	1.6	1.9	4.6	1.0	-2.1	-0.4
Eye problems/disorders: Glaucoma	1.2	1.4	3.3	1.8	0.7	-0.7
Medication: Blood pressure	0.6	1.1	2.6	-0.9	0.2	1.6
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.8	-0.7	1.3	-0.7
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.6	1.9	-0.4	0.4
High cholesterol (Self-reported)	1.9	3.4	6.7	-0.0	2.6	-1.8
Medication: Bendroflumethiazide	0.7	1.0	3.1	-0.2	0.2	1.8
Medication: Paracetamol	1.5	2.3	4.3	0.6	2.1	-1.5
Medication: Lisinopril	0.4	0.5	1.6	0.2	1.2	0.2
Medication: Atorvastatin	0.8	1.0	2.2	0.9	0.2	1.5
Illnesses of father: High blood pressure	2.4	3.0	5.0	-1.9	-0.7	2.2
Alcohol drinker status: Never	1.5	1.8	4.0	2.0	1.2	0.1
Ever smoked	1.0	1.8	2.5	-0.9	-1.5	1.6
Basal metabolic rate	2.8	15.5	44.0	-1.3	6.6	-0.9
Leg fat percentage (left)	1.9	6.9	16.9	0.8	4.1	-1.8
Arm fat-free mass (left)	2.4	12.3	35.2	-0.9	5.9	-0.8
Number of operations (self-reported)	0.8	1.1	2.7	-1.7	0.7	0.4
Average weekly beer plus cider intake	0.6	0.8	1.9	-0.5	-1.4	-0.6
Irritability	0.5	0.9	1.5	-0.7	1.2	-0.8
Risk taking	0.4	0.6	0.9	-0.4	0.9	0.8
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.3	0.9	-1.5	1.3
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.8	-0.2	0.3
Age started oral contraceptive pill	0.6	0.8	1.4	1.0	-1.2	-0.2
Diastolic blood pressure, automated reading	0.7	2.1	3.7	-1.4	1.9	-0.6
Ever depressed for a whole week	0.5	0.6	1.7	-1.3	-0.0	0.1
Unable to work because of sickness or disability	0.6	0.8	1.9	0.5	-0.3	1.4
Commuting to job workplace: Cycle	0.7	0.9	1.6	0.6	-0.8	1.3
Myopia	1.0	1.5	1.7	-1.3	1.1	1.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	5.1	0.5	-2.3	-0.9
Cholesterol lowering medication	0.4	0.6	1.6	-0.1	1.3	0.6
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.6	-1.9	0.1	0.3
Pain experienced in last month	2.0	3.3	7.9	-1.4	-2.8	0.4
Supplements: Calcium	0.4	0.5	0.9	0.5	-1.0	-0.5
Basal cell carcinoma (self-reported)	1.2	1.4	3.1	0.7	0.8	-1.8
Heart attack/myocardial infarction (self-reported)	0.4	0.6	0.9	-0.5	1.0	0.7
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	-0.4	-0.5	0.5
Heart disease (siblings)	0.2	0.2	0.7	0.0	0.1	0.8
Alcohol drinker status: Previous	0.5	0.5	1.3	-0.2	0.5	1.1
Pack years of smoking	0.4	0.6	1.3	-1.2	0.6	0.5
Impedance of whole body	2.0	10.4	25.4	-1.1	-5.0	2.2
Leg fat mass (left)	3.4	13.1	35.4	-0.4	6.0	-1.9
Arm predicted mass (left)	2.7	13.7	39.6	-1.0	6.3	-0.7