Best TWAS P=5.7e-13 · Best GWAS P=2.8e-27 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | HELLS | 0.04 | 0.04 | enet | 12 | 0.04 | 5.1e-06 | -4.9 | -7.2 | 8.1e-13 | 0.23 | 0.97 | 0.00 | FALSE |
2 | GTEx | Adrenal Gland | NOC3L | 0.21 | 0.10 | lasso | 5 | 0.18 | 4.4e-07 | -0.3 | -5.5 | 4.0e-08 | 0.80 | 0.03 | 0.96 | TRUE |
3 | GTEx | Nerve Tibial | PLCE1 | 0.35 | 0.11 | enet | 25 | 0.23 | 2.1e-16 | 1.4 | -7.2 | 5.7e-13 | 0.29 | 1.00 | 0.00 | TRUE |
4 | GTEx | Pituitary | CYP2C8 | 0.20 | 0.05 | lasso | 7 | 0.04 | 4.1e-02 | -5.8 | -5.8 | 7.7e-09 | 0.48 | 0.08 | 0.55 | TRUE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | PLCE1 | 0.11 | 0.09 | lasso | 2 | 0.07 | 7.1e-05 | 3.7 | -6.1 | 9.0e-10 | 0.23 | 0.18 | 0.08 | TRUE |
6 | GTEx | Testis | PIPSL | 0.14 | 0.00 | enet | 21 | 0.00 | 3.0e-01 | -1.9 | 6.8 | 7.7e-12 | -0.20 | 0.06 | 0.12 | TRUE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HELLS | 0.04 | 0.01 | blup | 47 | 0.03 | 1.3e-06 | -5.0 | -5.8 | 6.4e-09 | 0.20 | 0.04 | 0.96 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLCE1 | 0.11 | 0.09 | blup | 166 | 0.10 | 1.1e-19 | -3.1 | -6.5 | 6.2e-11 | 0.20 | 1.00 | 0.00 | TRUE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HELLS | 0.03 | 0.03 | blup | 47 | 0.03 | 1.7e-04 | -4.1 | -5.2 | 1.9e-07 | 0.08 | 0.39 | 0.51 | TRUE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NOC3L | 0.05 | 0.01 | enet | 5 | 0.03 | 6.3e-04 | 8.3 | -6.7 | 2.6e-11 | 0.70 | 0.08 | 0.73 | TRUE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLCE1 | 0.11 | 0.01 | blup | 167 | 0.05 | 3.9e-06 | 1.9 | -5.3 | 1.1e-07 | 0.22 | 0.35 | 0.04 | TRUE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TBC1D12 | 0.04 | 0.04 | blup | 63 | 0.03 | 3.9e-04 | -5.0 | -5.9 | 4.6e-09 | 0.12 | 0.24 | 0.50 | TRUE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | HELLS | 0.05 | 0.02 | blup | 47 | 0.03 | 9.6e-04 | -4.1 | -6.0 | 2.6e-09 | 0.24 | 0.08 | 0.80 | FALSE |