Best TWAS P=1.14e-13 · Best GWAS P=3.81e-13 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FAM177A1 | 0.07 | 0.05 | bslmm | 383 | 0.04 | 7.3e-06 | 5.68 | -6.3 | 3.2e-10 | -0.66 | 0.06 | 0.93 | FALSE |
2 | GTEx | Adipose Subcutaneous | PPP2R3C | 0.21 | 0.12 | lasso | 10 | 0.14 | 2.6e-11 | 5.96 | -6.0 | 2.3e-09 | -0.57 | 0.94 | 0.06 | FALSE |
3 | GTEx | Artery Tibial | FAM177A1 | 0.07 | 0.07 | enet | 11 | 0.07 | 2.1e-06 | 5.68 | -5.5 | 5.0e-08 | -0.67 | 0.14 | 0.82 | FALSE |
4 | GTEx | Artery Tibial | RP11-85K15.2 | 0.06 | 0.01 | lasso | 6 | 0.02 | 2.1e-02 | 5.63 | 6.5 | 1.0e-10 | 0.59 | 0.17 | 0.12 | FALSE |
5 | GTEx | Brain Cerebellum | FAM177A1 | 0.13 | 0.04 | lasso | 3 | 0.04 | 1.9e-02 | 7.26 | -7.4 | 1.1e-13 | -0.99 | 0.00 | 0.95 | TRUE |
6 | GTEx | Esophagus Mucosa | SRP54 | 0.13 | 0.05 | lasso | 5 | 0.05 | 1.6e-04 | 5.96 | -6.6 | 3.5e-11 | -0.83 | 0.01 | 0.99 | FALSE |
7 | GTEx | Nerve Tibial | SRP54 | 0.16 | 0.02 | enet | 14 | 0.08 | 1.3e-06 | 0.96 | 5.2 | 1.8e-07 | 0.36 | 0.25 | 0.68 | FALSE |
8 | GTEx | Nerve Tibial | FAM177A1 | 0.23 | 0.07 | enet | 37 | 0.10 | 1.1e-07 | 7.26 | -5.9 | 3.3e-09 | -0.77 | 0.00 | 0.99 | FALSE |
9 | GTEx | Testis | FAM177A1 | 0.30 | 0.16 | lasso | 5 | 0.23 | 1.2e-10 | 4.06 | 6.2 | 5.7e-10 | 0.83 | 0.01 | 0.99 | FALSE |
10 | GTEx | Thyroid | FAM177A1 | 0.13 | 0.04 | enet | 18 | 0.07 | 5.5e-06 | 4.66 | -5.2 | 1.8e-07 | -0.45 | 0.98 | 0.01 | FALSE |
11 | GTEx | Whole Blood | FAM177A1 | 0.16 | 0.09 | lasso | 6 | 0.09 | 1.8e-08 | 3.98 | 5.5 | 2.9e-08 | 0.68 | 0.96 | 0.04 | FALSE |
12 | NTR | Blood | KIAA0391 | 0.05 | 0.05 | lasso | 10 | 0.05 | 2.4e-15 | 5.96 | 6.3 | 3.6e-10 | 0.63 | 0.89 | 0.11 | FALSE |
13 | YFS | Blood | KIAA0391 | 0.29 | 0.36 | lasso | 7 | 0.38 | 5.8e-132 | 5.96 | 6.0 | 1.6e-09 | 0.62 | 0.88 | 0.12 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FAM177A1 | 0.03 | 0.02 | blup | 54 | 0.03 | 2.0e-04 | 4.71 | -5.6 | 2.4e-08 | -0.75 | 0.03 | 0.68 | FALSE |