TWAS hub - KIAA0391

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0488	0.0202	1.6e-03	0.033	0.013	0.012	0.012	0.020	9.8e-06	4.5e-03	5.5e-03	5.8e-03	5.1e-04
2	NTR	Blood	0.0517	0.0149	1.6e-12	0.050	0.046	0.048	0.045	0.049	1.2e-15	1.1e-14	2.4e-15	1.9e-14	2.4e-15
3	YFS	Blood	0.2905	0.0371	0.0e+00	0.361	0.352	0.376	0.373	0.377	6.8e-125	3.1e-121	1.5e-131	2.9e-130	5.8e-132
4	TCGA	Glioblastoma Multiforme	0.1990	0.0890	7.0e-03	-0.004	0.011	-0.003	NA	0.002	4.6e-01	1.5e-01	4.1e-01	NA	2.7e-01
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0944	0.0353	4.2e-06	0.065	0.060	0.065	NA	0.059	7.6e-08	2.5e-07	8.1e-08	NA	3.1e-07
6	TCGA	Brain Lower Grade Glioma	0.0696	0.0286	5.1e-06	0.045	0.040	0.035	NA	0.038	7.6e-06	2.0e-05	6.2e-05	NA	3.2e-05
7	TCGA	Lung Adenocarcinoma	0.0612	0.0250	3.5e-05	0.055	0.031	0.028	NA	0.038	4.6e-07	1.2e-04	2.7e-04	NA	2.5e-05
8	TCGA	Lung Squamous Cell Carcinoma	0.0660	0.0297	7.2e-04	0.007	0.029	0.045	NA	0.041	4.4e-02	2.9e-04	6.5e-06	NA	1.6e-05
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.1150	0.0540	1.7e-03	0.039	-0.002	0.005	NA	0.030	1.1e-03	4.9e-01	1.4e-01	NA	3.8e-03
10	TCGA	Pancreatic Adenocarcinoma	0.0980	0.0470	4.9e-03	0.090	0.051	0.080	NA	0.077	1.4e-04	3.5e-03	3.1e-04	NA	3.9e-04
11	TCGA	Testicular Germ Cell Tumors	0.1820	0.0730	6.4e-04	0.147	0.077	0.138	NA	0.009	7.3e-06	1.1e-03	1.4e-05	NA	1.5e-01
12	TCGA	Thyroid Carcinoma	0.1170	0.0380	2.1e-10	0.108	0.133	0.139	NA	0.132	1.3e-10	6.5e-13	2.0e-13	NA	8.4e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Hayfever, allergic rhinitis or eczema	7.8	17.0	45.4	5.8	2.9	1.8	1.4	4.9	-1.1	4.8	6.7	5.6	3.8	4.2	0.2
Allergy or Eczema	6.2	16.4	43.0	5.9	2.1	1.2	1.9	5.1	-0.9	4.9	6.6	5.7	3.8	3.5	0.8
Allergy	5.8	13.3	31.4	-5.1	-1.6	-0.7	-1.6	-4.9	-0.3	-4.4	-5.6	-5.0	-3.6	-3.4	-1.4
Mouth/teeth dental problems: Bleeding gums	5.8	7.5	15.6	-3.8	-0.1	0.5	-2.0	-3.6	-1.5	-3.6	-3.4	-4.0	-2.9	-1.7	-2.3
Schizophrenia (2014)	4.7	10.4	25.4	-4.7	0.2	1.1	-0.5	-5.0	-1.7	-4.1	-2.8	-4.9	-3.8	-2.6	-1.8
Depression (self-reported)	4.6	5.6	12.2	-2.9	-2.7	-2.2	0.8	-2.1	0.6	-2.6	-2.2	-2.6	-3.5	-2.9	1.4
Medication: Levothyroxine sodium	4.5	7.7	11.9	-3.4	-1.7	-1.0	-3.1	-3.2	-2.0	-3.4	-3.3	-3.2	-2.9	-3.0	-1.9
Schizophrenia (2018)	4.3	8.8	21.2	-4.4	-0.6	0.3	-0.9	-4.6	-1.1	-3.8	-3.2	-4.4	-3.4	-2.4	-1.4
Blood clot in the leg (DVT)	4.3	5.6	15.7	0.8	-3.0	-3.2	3.2	1.2	4.0	1.4	-0.2	1.5	1.7	-0.3	3.7
Deep venous thrombosis (DVT) (self-reported)	4.3	5.5	15.6	0.8	-3.0	-3.2	3.0	1.2	4.0	1.4	-0.4	1.4	1.6	-0.6	3.6
Crohns Disease (2017)	3.9	8.6	22.0	-3.8	-1.3	-0.8	-1.9	-4.0	-0.2	-3.7	-4.7	-3.7	-3.3	-2.1	-1.4
Schizophrenia vs Biploar Disorder	3.7	4.9	10.5	-2.8	1.0	1.4	-1.0	-3.2	-1.8	-3.0	-1.6	-3.2	-2.4	-1.1	-1.9
Frequency of depressed mood in last 2 weeks	3.7	5.2	12.8	-1.9	-3.6	-3.4	1.5	-1.5	2.5	-2.1	-2.1	-1.4	-2.3	-2.1	2.0
Rheumatoid Arthritis	3.5	4.8	7.4	2.0	-1.8	-2.0	2.5	2.7	2.6	2.2	1.3	2.5	2.5	-0.1	2.5
Irritable Bowel Disease (IBD)	3.4	8.2	28.4	-3.6	-2.2	-1.4	-1.3	-3.1	0.5	-3.4	-5.3	-3.4	-3.0	-2.4	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.4	4.4	11.5	-2.4	-3.4	-3.1	0.3	-1.3	0.9	-1.3	-2.2	-1.8	-2.0	-2.9	0.8
Hypothyroidism/myxoedema (self-reported)	3.3	6.5	10.8	-3.1	-0.4	0.3	-3.3	-3.1	-2.1	-3.3	-2.8	-3.2	-2.6	-1.9	-2.1
Blood White Count	3.2	23.4	53.5	-3.5	5.2	6.3	-7.3	-3.6	-6.0	-4.1	-2.4	-4.7	-4.3	0.1	-5.9
Frequency of tenseness / restlessness in last 2 weeks	3.2	5.0	14.7	-1.2	-3.8	-3.7	1.8	-0.6	3.1	-0.8	-1.8	-0.6	-0.8	-2.2	2.6
Arm fat-free mass (right)	3.2	16.4	44.0	1.9	-5.8	-6.6	3.3	2.9	5.8	3.6	-1.5	3.3	1.6	-0.0	5.8
Arm fat-free mass (left)	3.1	15.7	37.3	2.4	-5.1	-6.1	2.6	3.4	5.5	4.2	-1.1	3.8	2.0	0.9	5.6
Risk taking	3.1	4.5	8.3	-2.9	-2.5	-1.7	-0.1	-2.2	0.9	-2.2	-2.5	-2.6	-2.5	-2.2	1.2
Breast Cancer	3.0	7.3	13.9	3.4	3.1	2.8	-0.2	2.8	-0.8	2.8	3.5	2.9	2.9	3.7	0.2
Crohns Disease (2012)	3.0	4.8	10.3	-2.5	-0.3	-0.1	-2.1	-3.2	-1.1	-3.1	-2.5	-2.5	-3.1	-1.0	-1.7
Trunk fat-free mass	3.0	17.1	35.9	3.1	-4.9	-6.0	3.4	3.8	5.6	4.5	0.0	4.4	2.5	0.9	5.7
Trunk predicted mass	3.0	17.4	36.6	3.1	-5.0	-6.0	3.4	3.8	5.6	4.5	0.0	4.4	2.5	0.9	5.7
Arm predicted mass (left)	3.0	15.5	34.1	2.6	-4.9	-5.8	2.7	3.5	5.5	4.2	-0.9	3.9	2.2	0.9	5.5
Alzheimer’s Disease (in father)	2.9	3.2	7.5	-2.3	-2.3	-1.8	-0.4	-1.6	0.8	-1.8	-2.7	-1.9	-2.0	-1.1	1.0
Impedance of arm (right)	2.9	13.4	39.3	-0.3	6.3	6.0	-1.7	-2.2	-4.6	-2.4	3.9	-1.6	-1.2	2.7	-4.8
Arm predicted mass (right)	2.9	15.1	39.8	1.9	-5.5	-6.3	2.9	2.9	5.5	3.6	-1.5	3.3	1.7	0.2	5.6
Primary Biliary Cirrhosis	2.8	4.0	9.0	-2.8	0.7	1.1	-1.3	-2.9	-0.6	-2.5	-2.6	-3.0	-2.2	-0.2	-1.3
Whole body fat-free mass	2.8	16.0	39.4	2.4	-5.3	-6.3	3.4	3.2	5.6	3.9	-0.4	3.8	1.9	0.4	5.7
Whole body water mass	2.8	16.0	39.2	2.5	-5.2	-6.3	3.5	3.2	5.6	3.9	-0.4	3.8	1.8	0.4	5.7
Impedance of arm (left)	2.6	12.0	30.2	-0.9	5.5	5.4	-1.3	-2.9	-4.6	-3.0	3.3	-2.1	-1.8	1.6	-4.7
Basal metabolic rate	2.6	14.3	36.7	2.2	-5.2	-6.1	3.0	2.9	5.3	3.6	-0.6	3.5	1.5	0.4	5.5
Hypothyroidism (self reported)	2.5	5.6	11.1	-3.2	-1.1	-0.3	-3.3	-2.5	-1.1	-2.7	-3.3	-3.0	-2.2	-1.9	-1.4
Alcohol usually taken with meals	2.5	4.1	12.9	2.7	1.2	0.9	1.3	2.3	-0.3	2.6	3.6	2.2	2.0	1.6	1.0
Number of children fathered	2.5	2.8	6.4	1.4	-1.3	-1.7	0.6	2.2	1.7	2.5	0.6	2.2	2.1	0.2	1.8
Number of operations (self-reported)	2.5	3.7	10.0	0.5	-2.7	-2.1	2.9	0.6	2.2	0.8	0.1	0.8	1.0	-2.5	3.2
Tense / ‘highly strung’	2.4	4.0	7.7	-2.5	-2.6	-2.4	0.5	-1.7	1.7	-1.9	-2.8	-1.8	-2.0	-1.5	0.9
Bipolar Disorder or Schizophrenia	2.3	5.6	14.1	-3.4	-0.1	0.6	0.5	-3.8	-0.7	-3.0	-2.0	-3.7	-2.7	-2.2	-0.9
Depression (Nagel 2018)	2.3	3.4	9.0	-1.5	-3.0	-2.8	0.9	-0.9	2.1	-1.6	-1.8	-1.1	-2.1	-1.5	1.3
Leg predicted mass (left)	2.3	11.9	33.9	1.7	-4.9	-5.8	3.2	2.2	4.9	2.9	-0.3	3.0	1.0	0.1	5.1
Happiness	2.3	2.8	6.6	-2.0	0.3	0.4	-1.2	-2.0	-1.2	-2.3	-1.3	-2.2	-2.6	-0.8	-1.7
Leg fat-free mass (right)	2.3	12.3	37.7	1.5	-5.3	-6.1	3.3	1.9	4.9	2.6	-0.6	2.7	0.7	-0.3	5.1
Leg predicted mass (right)	2.3	12.2	37.0	1.5	-5.2	-6.1	3.3	1.9	4.9	2.6	-0.5	2.8	0.8	-0.3	5.1
Impedance of whole body	2.3	11.8	33.3	-0.8	5.6	5.8	-2.4	-2.2	-4.6	-2.5	2.5	-2.0	-1.2	2.0	-4.7
Leg fat-free mass (left)	2.2	11.7	33.6	1.7	-4.9	-5.8	3.1	2.1	4.8	2.9	-0.3	2.9	0.9	0.1	5.0
Mood swings	2.2	4.0	8.6	-1.9	-2.9	-2.6	1.1	-1.4	2.1	-2.0	-2.6	-1.4	-2.2	-1.3	1.5
Medication: Gliclazide	2.2	2.4	5.6	-2.3	-0.3	-0.2	0.1	-1.9	0.5	-2.1	-2.2	-2.4	-1.8	-1.3	-0.2
Neuroticism (2016)	2.1	3.1	6.1	-2.3	-1.8	-1.8	-0.8	-1.7	0.7	-2.0	-2.5	-2.0	-2.2	-1.3	-0.2
Ulcerative Colitis (UC)	2.0	3.7	16.2	-2.1	-2.3	-1.5	-0.4	-1.1	1.1	-1.7	-4.0	-1.8	-1.7	-1.7	1.5
Friendships satisfaction	2.0	2.5	5.9	-2.1	-0.6	-0.6	-0.8	-1.9	-0.5	-2.0	-2.4	-1.8	-2.2	-1.1	-1.0
Ever taken oral contraceptive pill	2.0	2.2	6.4	-1.3	-2.4	-1.8	-0.1	-0.2	1.4	-0.8	-1.4	-0.8	-1.2	-2.5	1.5
Had other major operations	1.9	2.3	7.8	-0.6	-2.6	-2.2	1.0	-0.3	1.3	0.2	-0.9	-0.3	0.5	-2.8	2.0
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	6.6	2.0	1.2	1.0	-0.7	1.9	-1.2	2.0	2.6	1.8	1.0	1.9	-0.3
Ever highly irritable/argumentative for 2 days	1.9	2.3	5.8	-2.0	-0.8	-0.9	0.7	-2.4	0.2	-2.4	-1.0	-1.7	-2.3	-0.7	-0.4
Commuting to job workplace: Car/motor vehicle	1.9	2.2	6.6	0.3	-2.4	-2.6	1.1	1.4	1.8	1.3	-0.4	0.9	0.4	-0.5	2.1
Commuting to job workplace: Public transport	1.9	2.3	6.3	-0.3	2.4	2.5	-1.9	-0.8	-1.9	-1.1	-0.2	-0.9	-0.6	0.3	-2.1
BMI	1.8	10.4	27.7	0.9	-4.7	-4.9	1.2	2.3	4.9	2.6	-2.7	2.0	1.0	-0.0	5.3
Weight	1.8	8.7	23.1	1.4	-4.2	-4.8	1.7	2.1	4.3	2.7	-1.1	2.5	0.8	0.4	4.5
Ever had prostate specific antigen (PSA) test	1.8	2.1	7.2	1.2	2.7	2.4	0.1	0.1	-1.0	0.5	1.7	0.6	0.7	2.0	-1.4
Basal cell carcinoma (self-reported)	1.8	2.2	5.7	-0.7	-2.2	-2.4	1.9	-0.5	2.2	0.0	-1.5	-0.2	0.4	-1.0	1.9
Blood Eosinophil Count	1.7	13.0	48.4	4.7	1.1	0.9	-0.7	7.0	1.5	5.3	1.8	4.3	3.4	4.0	1.9
Taking other prescription medications	1.7	2.6	8.9	-2.0	-1.2	-0.5	-1.7	-1.4	-0.3	-1.4	-2.2	-1.9	-1.2	-3.0	-0.3
Father’s age at death	1.7	2.3	5.9	-0.6	2.2	2.4	-1.4	-0.9	-2.2	-1.1	0.1	-1.2	-1.3	0.7	-2.0
Wheeze or whistling in the chest in last year	1.7	3.1	8.1	2.5	-1.0	-0.7	0.3	2.8	0.9	2.1	1.5	2.5	1.6	-0.4	2.0
Medication: Paracetamol	1.7	2.6	5.2	-2.0	-0.2	-0.1	-1.5	-1.5	-0.9	-2.0	-2.3	-2.0	-2.2	-0.5	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	7.8	-0.8	-2.8	-2.4	0.5	-0.2	1.4	-0.8	-1.5	-0.4	-1.2	-1.6	1.5
Asthma	1.6	3.1	9.0	2.6	-0.2	-0.1	-0.8	3.0	0.4	2.3	1.4	2.6	1.6	1.1	1.5
Medication: Ventolin 100micrograms inhaler	1.6	2.0	5.4	2.1	1.0	0.6	-1.0	2.3	-0.7	1.8	1.4	2.1	1.2	0.7	-0.2
Supplements: Vitamin C	1.6	1.9	5.8	-0.1	2.0	2.4	-0.9	-1.2	-2.0	-0.8	1.3	-0.8	-0.8	0.9	-1.2
Wears glasses or contact lenses	1.6	1.8	3.8	1.4	1.6	1.2	-0.4	0.8	-1.5	1.2	1.9	1.2	0.9	2.0	-1.3
Leg fat mass (left)	1.6	6.3	17.4	0.1	-4.0	-4.2	0.5	1.3	3.8	1.7	-2.6	1.1	0.3	-0.3	3.9
Impedance of leg (right)	1.5	7.5	25.6	0.1	4.9	5.1	-2.6	-0.4	-3.3	-0.7	1.6	-0.9	0.4	2.4	-3.6
Age when periods started (menarche)	1.5	3.6	10.3	0.0	2.7	3.1	-3.2	-0.1	-2.7	-0.6	-0.2	-1.0	-0.9	0.5	-2.5
Serious illness, injury or assault to yourself	1.5	1.8	5.9	0.5	-1.9	-1.8	1.2	0.6	2.1	0.7	-0.6	0.8	1.2	-0.2	2.4
Waist circumference	1.5	5.4	13.6	1.3	-3.4	-3.7	1.4	2.0	3.1	2.2	-0.3	2.1	0.7	-0.1	3.6
Leg fat mass (right)	1.5	5.9	15.8	0.1	-3.8	-4.0	0.5	1.3	3.7	1.8	-2.5	1.1	0.4	-0.3	3.8
Hand grip strength (right)	1.4	3.7	12.0	1.8	-0.8	-1.0	-1.5	3.1	0.6	3.5	0.2	2.4	2.7	1.0	1.3
Body mass index (BMI)	1.4	6.1	17.4	-0.3	-4.2	-4.1	0.5	0.9	3.5	1.2	-2.8	0.7	-0.1	-1.1	3.7
Medication: Simvastatin	1.4	2.1	8.7	-1.4	-2.0	-1.6	-0.2	-0.6	1.7	-0.6	-3.0	-1.1	-0.7	-1.4	1.0
Pulse rate	1.4	2.3	7.3	0.3	-2.6	-2.7	1.7	0.9	1.7	1.0	-0.6	1.1	0.7	-1.0	1.8
Pulse wave Arterial Stiffness index	1.4	1.6	3.6	1.7	0.7	0.4	-0.6	1.5	-0.5	1.9	1.2	1.7	1.4	1.8	-0.1
Angina (self-reported)	1.4	1.9	5.6	1.7	-0.0	-0.2	-0.6	2.3	0.1	2.4	1.0	1.9	1.7	0.1	0.7
Comparative height size at age 10	1.4	7.5	13.2	3.1	-1.5	-2.7	3.4	2.5	2.9	3.0	2.7	3.6	1.3	1.9	3.3
Family relationship satisfaction	1.4	1.8	4.7	-1.2	0.1	0.3	-0.9	-1.4	-1.4	-1.8	-1.4	-1.2	-2.2	-1.2	-1.4
Hearing aid user	1.4	1.6	3.5	1.5	1.1	0.8	-0.3	1.3	0.4	1.8	1.4	1.5	1.9	1.5	0.5
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.8	1.7	0.8	0.6	-0.7	1.1	-0.5	1.5	1.8	2.0	1.8	0.9	-0.3
Respiratory disease	1.3	2.8	8.0	2.5	0.8	1.0	-1.2	2.8	-0.7	1.8	2.2	2.3	0.7	1.0	0.8
Lung FVC	1.3	6.5	13.8	-3.4	-2.0	-1.1	-2.4	-2.3	-1.2	-2.5	-2.4	-3.2	-3.7	-3.5	-0.9
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.4	-1.9	0.1	0.1	0.5	-1.6	0.3	-2.1	-0.8	-2.0	-1.8	-1.0	-0.4
Lung cancer (father)	1.3	1.5	4.7	-1.2	-1.4	-1.1	0.3	-1.2	0.5	-1.2	-1.7	-1.0	-1.2	-2.2	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	6.6	-0.2	-2.6	-2.4	1.3	0.3	1.5	-0.1	-0.2	0.2	-1.2	-1.2	2.0
Knee pain experienced in last month	1.3	2.0	6.5	-0.6	1.0	1.7	-2.5	-0.5	-2.3	-1.0	-0.5	-1.1	-1.8	-0.4	-1.3
Cholesterol lowering medication	1.3	1.9	7.4	-1.4	-2.0	-1.4	-1.7	-0.9	0.6	-0.2	-2.7	-1.1	-0.4	-1.4	0.4
Angina	1.2	1.6	4.9	1.5	-0.3	-0.4	-0.4	2.2	0.2	2.2	0.8	1.7	1.6	-0.1	0.8
Medication for hormone replacement therapy	1.2	1.3	4.8	1.7	0.2	0.2	1.6	1.1	-0.3	0.5	2.2	1.6	0.7	-0.3	0.8
Severe depression (siblings)	1.2	1.4	4.6	-0.4	-2.1	-1.6	0.5	0.3	1.1	-0.2	-0.6	-0.1	-0.8	-2.1	1.5
Impedance of leg (left)	1.2	6.1	19.6	-0.4	4.1	4.4	-2.8	-0.9	-3.1	-1.2	0.8	-1.3	-0.0	1.7	-3.3
Chest pain or discomfort	1.2	1.7	6.3	0.2	-2.5	-2.0	-0.4	0.4	0.8	0.2	-1.0	0.5	-0.1	-2.2	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	4.7	-0.4	1.7	2.2	-2.2	-0.8	-1.2	-0.3	-0.8	-0.6	0.2	0.4	-0.9
Asthma (self-reported)	1.2	2.4	7.7	2.2	-0.0	0.1	-1.1	2.8	0.2	2.0	1.3	2.3	1.3	1.2	1.2
Commuting to job workplace: Cycle	1.2	1.5	5.2	0.8	2.3	2.0	-0.9	0.1	-0.9	0.3	1.4	-0.0	0.0	1.4	-1.5
Alzheimer’s Disease (including proxy)	1.1	1.6	5.3	-0.7	-2.0	-2.0	-0.1	0.3	1.6	0.6	-2.3	-0.3	0.4	-0.4	1.5
Major Depression (MDD)	1.1	1.3	2.5	-1.4	-1.5	-1.4	-0.2	-1.1	0.9	-1.1	-1.2	-0.9	-1.6	-1.2	0.4
Lupus	1.1	1.6	5.1	-0.2	-2.0	-2.3	1.0	-0.1	2.0	0.0	-1.6	0.4	-0.2	0.8	1.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.3	0.3	-2.0	-1.6	1.0	0.4	0.5	0.2	1.0	0.5	-0.6	-2.1	1.5
Medication: Paracetamol	1.1	1.8	4.6	-1.6	-0.7	-0.7	-1.8	-1.4	-0.6	-1.5	-2.1	-1.3	-1.8	-0.3	-1.3
Suffer from ‘nerves’	1.1	1.8	5.0	-1.2	-2.2	-2.0	0.1	-0.7	0.7	-1.3	-2.0	-0.7	-1.7	-0.7	0.4
Ever had bowel cancer screening	1.1	1.3	4.6	-1.2	-0.7	-0.2	-0.1	-1.4	0.5	-1.5	-2.1	-1.5	-1.1	-0.7	0.1
Breast cancer (self-reported)	1.1	1.3	3.0	-1.7	-1.2	-0.6	0.7	-0.4	0.9	-0.6	-1.4	-1.7	-0.4	-1.6	0.9
Number of self-reported non-cancer illnesses	1.1	1.8	5.5	-1.7	-0.9	-0.4	-1.7	-1.1	-0.4	-1.1	-1.5	-1.5	-1.5	-2.4	-0.6
Ever smoked	1.1	2.0	5.9	-1.3	-0.9	-0.1	-1.8	-1.2	-0.9	-1.6	-1.3	-1.5	-2.4	-1.8	0.4
Ovarian Cancer	1.0	1.3	3.7	0.5	1.9	1.9	-0.6	-0.4	-1.2	-0.3	1.1	0.1	-0.1	1.9	-1.0
Smoking Status	1.0	2.4	4.7	-2.1	-1.1	-0.4	-0.7	-1.6	0.4	-1.7	-1.9	-2.1	-2.2	-1.6	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	8.4	1.5	1.1	0.1	0.6	2.2	1.4	2.0	-0.2	1.4	1.6	2.9	-0.1
Medication: Ramipril	1.0	1.2	3.4	0.5	-1.4	-1.5	1.0	1.2	1.8	1.1	-0.6	0.8	0.6	-0.4	1.4
Time employed in main current job	1.0	1.1	3.2	0.2	-1.6	-1.5	0.2	1.3	0.8	0.9	-1.8	0.4	0.4	-0.5	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	4.3	-1.4	-1.8	-1.6	0.1	-1.2	0.0	-1.7	-1.1	-0.9	-1.4	-2.1	0.4
Falls in the last year	1.0	1.3	3.1	-0.8	-1.0	-0.7	1.8	-1.5	0.8	-1.6	-0.0	-0.9	-1.2	-1.6	0.5
Peak expiratory flow (PEF)	1.0	2.3	4.5	1.4	-1.4	-2.1	1.3	1.7	1.0	1.8	2.1	1.9	0.7	0.2	1.2
Pulse wave reflection index	1.0	1.2	3.0	1.0	1.7	1.7	-0.9	0.4	-1.3	0.9	0.9	0.7	0.8	1.3	-0.9
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	6.7	1.1	1.9	1.7	-0.3	-0.2	-1.9	0.1	2.6	0.6	0.6	0.9	-0.8
Pulse wave peak to peak time	1.0	1.2	2.7	-1.5	-0.5	-0.3	0.5	-1.2	0.5	-1.6	-1.0	-1.5	-1.3	-1.4	0.0
Medication for pain relief, constipation, heartburn	1.0	1.6	5.1	1.7	1.2	1.2	0.8	1.2	-0.6	1.3	2.2	1.5	1.6	0.5	0.1
Medication: Blood pressure	1.0	1.8	5.1	-0.8	-2.2	-2.3	1.3	0.1	2.1	-0.3	-1.6	-0.3	-0.8	-0.7	1.3
Number of full sisters	1.0	1.3	3.3	-1.5	-1.1	-0.6	-0.6	-1.3	0.3	-0.9	-1.5	-1.4	-0.9	-1.8	0.4
Medication: Aspirin	1.0	1.3	4.9	0.0	-1.2	-1.4	0.4	0.9	2.2	1.1	-1.4	0.5	1.0	0.1	1.5
Illnesses of siblings: Diabetes	1.0	1.2	2.8	0.7	-0.8	-1.0	0.8	1.2	1.7	1.0	-1.4	0.8	1.4	0.2	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	4.8	-2.2	-0.0	-0.1	0.1	-2.1	-0.6	-2.1	-0.9	-2.2	-1.8	-1.2	-1.5
Arm fat mass (left)	1.0	4.0	12.1	-0.2	-3.2	-3.5	0.6	0.6	3.0	0.8	-2.0	0.7	-0.7	-0.2	3.1
Guilty feelings	1.0	1.4	4.1	-1.6	-0.5	-0.1	0.4	-1.5	-0.2	-2.0	-0.7	-1.7	-1.6	-1.4	-0.1
Mother’s age at death	1.0	1.3	2.6	1.1	1.6	1.1	-0.8	0.9	-1.2	1.0	1.3	0.9	0.6	0.9	-1.6
Fractured/broken bones in last 5 years	1.0	1.2	5.2	1.5	0.8	1.0	-0.9	0.3	-1.6	0.9	2.3	1.0	0.7	-0.4	-0.3
Coronary Artery Disease (CAD)	0.9	1.1	3.3	0.3	-1.1	-1.1	1.8	0.7	1.8	0.5	-0.6	0.5	1.0	0.1	1.1
Heel T-Score	0.9	6.8	21.2	1.1	4.0	2.5	-4.0	1.7	-0.2	1.6	-2.0	0.4	1.2	4.6	-3.2
Medication: Co-codamol	0.9	1.1	2.0	-1.3	-0.8	-0.6	-0.3	-1.0	-0.4	-1.4	-1.2	-1.3	-1.0	-1.4	-0.8
Financial difficulties in last 2 years	0.9	1.3	2.6	-1.6	-0.5	-0.5	-1.6	-1.4	-0.6	-1.4	-1.0	-1.1	-1.4	-0.1	-1.0
Medication: Lansoprazole	0.9	1.0	3.8	-1.2	-0.1	-0.3	0.9	-1.9	-0.2	-1.6	-0.3	-1.1	-0.8	-0.8	-0.6
Birth weight of first child	0.9	1.6	2.7	-1.5	-1.3	-1.4	-0.3	-1.4	0.2	-1.4	-1.5	-1.3	-1.6	-1.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	4.5	-0.8	-1.9	-2.1	0.1	-0.5	1.1	0.0	-1.1	0.0	-0.3	-0.6	0.6
Whole body fat mass	0.9	3.8	10.7	-0.1	-3.0	-3.3	0.4	0.7	3.1	1.0	-2.2	0.7	-0.3	0.2	3.1
Illnesses of father: Heart disease	0.9	1.2	4.9	-0.6	1.1	1.2	-2.2	-0.7	-1.5	-0.2	-0.3	-0.8	0.2	0.2	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.7	-1.0	-1.4	-1.6	0.0	-0.9	1.1	-0.8	-1.2	-0.6	-1.2	-0.3	0.5
Medication: Aspirin	0.9	1.2	4.0	0.1	-1.3	-1.5	0.1	1.0	2.0	1.1	-1.3	0.7	0.8	-0.1	1.2
Average weekly champagne plus white wine intake	0.9	1.2	2.3	0.8	-1.0	-1.4	1.0	1.1	1.3	1.5	0.8	1.0	1.4	0.3	1.0
Financial situation satisfaction	0.9	1.1	3.0	-1.2	-0.4	-0.3	0.4	-1.4	0.1	-1.7	-1.1	-1.3	-1.4	-0.9	-0.4
Leg fat percentage (left)	0.9	3.1	9.5	-0.7	-2.7	-2.5	-1.1	0.6	2.4	0.9	-3.1	-0.1	0.0	-0.3	2.5
Alcohol drinker status: Previous	0.9	1.1	3.4	-0.3	-1.2	-1.4	0.7	0.4	1.8	0.2	-1.6	-0.1	0.7	-0.9	1.2
Cardiovascular Disease	0.8	2.6	12.2	-1.7	-2.1	-1.8	-1.4	0.1	1.7	-0.3	-3.5	-1.0	-0.8	-1.5	0.6
Chronotype (morning person)	0.8	1.9	10.0	1.5	-0.0	-0.1	0.2	1.5	1.2	1.9	0.3	1.5	3.2	0.5	0.9
Relative age voice broke	0.8	1.2	3.9	-0.2	1.7	2.0	-0.9	-1.1	-1.3	-0.8	0.4	-0.7	0.3	0.4	-1.6
Multivitamins +/- minerals	0.8	1.0	2.1	-0.7	0.6	1.0	1.0	-1.2	-1.0	-1.4	1.0	-1.0	-1.3	-1.0	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	4.4	1.2	0.4	-0.7	0.2	2.1	1.6	1.8	-0.8	1.3	1.4	2.0	0.0
Illnesses of siblings	0.8	1.1	5.9	0.4	1.4	1.1	0.8	-0.5	-1.4	0.0	2.4	0.2	0.4	0.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.2	-0.9	-0.4	0.0	-2.1	-0.5	-0.7	-0.5	-1.9	-0.9	-1.2	0.4	-0.6
Arm fat mass (right)	0.8	3.4	9.8	0.0	-2.9	-3.1	0.4	0.7	2.9	0.9	-1.8	0.7	-0.6	0.1	2.9
Standing height	0.8	7.6	16.0	3.6	-0.5	-1.9	2.5	2.5	2.0	3.4	3.2	4.0	2.0	3.1	2.2
Exposure to tobacco smoke outside home	0.8	1.1	3.2	-1.0	0.5	0.6	0.5	-1.4	-1.2	-1.8	0.5	-1.3	-1.4	-0.9	-0.8
Comparative body size at age 10	0.8	2.2	6.2	0.9	-1.5	-1.7	0.5	1.3	2.5	1.4	-1.0	1.4	0.6	1.5	2.1
Emphysema/chronic bronchitis	0.8	0.9	4.4	-0.2	-2.1	-2.1	-0.3	0.2	0.3	0.1	-0.5	0.4	-0.8	-0.4	0.6
Overall health rating	0.8	1.7	7.3	0.0	-2.7	-2.1	-0.3	0.1	0.5	-0.1	-0.4	0.4	-0.3	-2.2	1.6
Diabetes diagnosed by doctor	0.8	1.3	6.3	-0.7	-1.6	-1.5	-0.6	0.2	1.4	0.4	-2.5	-0.3	-0.1	-0.9	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	3.2	-0.3	1.2	0.9	1.8	-1.0	-0.3	-0.8	1.7	-0.7	-0.1	-0.2	-0.6
Smoking status: Current	0.8	1.2	2.6	-1.6	-0.6	-0.1	0.5	-1.5	-0.1	-1.5	-0.3	-1.5	-1.6	-1.3	0.4
High cholesterol (Self-reported)	0.8	1.5	8.5	-0.9	-0.8	-0.7	-2.5	0.0	0.3	0.3	-2.9	-0.6	-0.5	-0.2	-0.3
Unable to work because of sickness or disability	0.8	1.1	2.9	-1.0	-1.5	-1.3	0.8	-1.1	-0.1	-1.2	-0.2	-0.7	-1.3	-1.7	0.3
Supplements: Calcium	0.8	0.9	3.6	0.2	1.0	0.9	-0.1	-0.5	-1.7	-0.7	1.9	0.0	-0.6	0.4	-0.8
Intelligence (Savage-Jansen 2018)	0.7	2.0	3.8	-1.6	1.4	1.6	-1.8	-1.7	-1.2	-1.2	-0.8	-1.9	-0.9	0.3	-1.7
Alzheimer’s Disease (in mother)	0.7	0.8	2.3	-0.4	-1.4	-1.5	0.2	0.3	0.9	0.6	-1.5	0.1	0.7	-1.1	0.7
Body Mass Index (BMI) (2010)	0.7	0.9	1.9	1.0	-0.9	-1.0	1.0	0.7	1.4	1.0	0.7	1.2	0.8	0.1	1.2
Ulcerative Colitis	0.7	1.0	3.5	-1.4	-0.8	-0.3	-0.2	-0.8	0.3	-1.1	-1.9	-1.3	-1.1	-0.7	0.7
Waist Hip Ratio (WHR)	0.7	3.0	7.8	2.5	0.5	0.4	0.3	2.6	-0.0	2.3	2.0	2.3	2.8	0.4	0.6
Number of treatments/medications taken	0.7	1.2	4.3	-1.1	-1.2	-0.7	-1.1	0.3	0.5	-0.3	-2.0	-1.0	-0.8	-2.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.9	-0.9	-1.2	-1.0	-0.4	-0.8	0.4	-0.7	-1.7	-0.7	-0.6	-1.4	0.2
Vitamin and mineral supplements	0.7	1.0	2.2	0.7	-0.7	-0.9	-0.5	1.1	1.5	1.2	-1.2	0.9	1.4	0.6	0.4
Medication: Metformin	0.7	1.0	3.6	-1.5	-0.8	-0.6	-0.1	-1.1	0.8	-0.8	-1.9	-1.2	-0.3	-1.1	0.4
Mouth/teeth dental problems	0.7	1.1	4.0	1.1	0.7	0.4	1.7	1.0	0.1	0.8	2.0	1.1	1.0	0.3	0.2
Pain all over the body in last month	0.7	0.7	1.7	-1.0	0.2	0.3	-0.2	-1.0	-0.9	-1.2	-1.3	-1.0	-0.7	-0.2	-1.2
Alcohol intake versus 10 years previously	0.7	1.0	2.5	-1.0	0.3	0.8	-1.4	-1.0	-1.6	-1.0	-0.6	-1.1	-0.6	-0.8	-1.3
Medication: Cholesterol lowering	0.7	1.1	4.8	-0.3	-1.3	-1.2	-0.2	1.0	1.6	0.8	-2.2	-0.0	0.3	-0.4	0.9
Prospective memory result	0.7	0.9	2.3	0.8	1.3	0.7	0.2	0.8	-0.8	1.0	1.5	0.8	1.1	0.9	-1.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.8	0.5	-1.7	-1.5	0.3	0.3	1.1	0.5	-0.5	0.6	-0.3	-0.1	1.5
Leg fat percentage (right)	0.7	2.4	7.5	-0.6	-2.2	-2.0	-1.0	0.7	2.2	1.0	-2.7	0.0	0.2	-0.1	2.2
Number of full brothers	0.7	0.8	3.8	-0.3	-1.2	-1.1	1.0	0.1	1.1	-0.1	-0.5	-0.3	0.6	-1.9	0.8
Neck or shoulder pain in last month	0.7	1.0	2.9	-0.9	-1.6	-1.4	-1.5	-0.9	0.6	0.0	-1.7	-0.6	-0.2	-0.5	0.3
Medication: Ibuprofen	0.7	0.9	3.5	-0.8	-0.4	0.0	-1.9	-0.6	-0.8	-0.6	-1.6	-0.8	-1.0	0.3	-0.6
Had major operations	0.7	0.9	4.4	-1.1	-0.6	-0.0	1.1	-0.5	0.3	-0.7	-0.6	-1.3	-0.6	-2.1	0.3
Long-standing illness, disability or infirmity	0.7	1.0	4.6	-0.7	-1.4	-1.2	-1.1	-0.6	-0.3	-0.4	-1.2	-0.4	-0.7	-2.1	-0.2
Illnesses of father: None of the above (group 1)	0.7	0.9	4.0	0.7	-0.4	-0.8	2.0	0.3	1.1	0.4	1.4	0.9	0.7	-0.3	0.9
Prostate Cancer	0.6	0.8	4.2	0.5	0.6	0.4	-1.4	0.2	-2.0	0.2	0.1	0.6	-0.5	0.2	-1.4
Fasting Glucose	0.6	0.7	2.8	0.6	1.0	0.8	-0.4	-1.1	-1.2	-0.7	0.5	-0.2	-0.0	0.5	-1.7
HbA1C	0.6	0.7	2.3	-0.3	-0.8	-0.9	0.7	-0.1	1.0	-1.2	-0.4	-0.6	-1.5	0.6	0.6
Blood Red Count	0.6	5.6	17.4	0.5	3.5	2.7	-4.2	0.3	-2.3	1.1	0.6	0.2	-0.4	3.0	-3.6
Ever had hysterectomy (womb removed)	0.6	0.7	2.9	-1.1	-0.6	0.2	-0.7	-0.3	0.0	-0.6	-1.2	-1.1	-0.2	-1.7	-0.1
Systolic blood pressure, automated reading	0.6	1.8	7.0	-1.1	0.5	0.9	-2.5	-0.2	-1.3	-0.4	-2.6	-1.1	-0.8	0.3	-1.6
Townsend deprivation index at recruitment	0.6	0.8	2.1	-0.7	-1.4	-1.0	-0.4	-0.5	0.9	-0.9	-0.6	-0.5	-0.6	-1.4	1.0
Current tobacco smoking	0.6	1.0	2.4	-1.4	0.0	0.5	-0.1	-1.4	-0.5	-1.5	-0.2	-1.5	-1.6	-0.6	-0.1
Qualifications: CSEs or equivalent	0.6	0.8	2.6	0.7	-1.2	-1.6	0.8	0.1	1.0	0.6	0.1	1.2	0.8	0.9	0.9
Trunk fat mass	0.6	2.6	7.5	0.2	-2.3	-2.7	0.3	0.6	2.6	1.0	-1.5	0.7	-0.4	0.6	2.7
Number of incorrect matches in round	0.6	1.0	3.0	-0.2	1.7	1.7	-0.0	-0.8	-1.2	-1.0	0.6	-0.7	-0.5	0.1	-1.4
Hair/balding pattern: Pattern 2	0.6	0.7	2.2	0.2	-1.0	-1.1	0.9	0.9	1.4	0.6	0.4	0.4	0.4	-0.5	1.5
Diabetes (self-reported)	0.6	1.0	6.0	-0.4	-1.2	-1.2	-1.2	0.1	1.1	0.4	-2.4	-0.0	-0.2	-0.1	0.6
Hip circumference	0.6	2.5	8.9	0.2	-2.5	-3.0	0.9	0.1	2.3	0.8	-0.4	0.9	-0.9	0.5	2.4
Gout (self-reported)	0.6	0.8	2.8	-0.9	0.6	1.0	0.5	-1.0	0.2	-1.7	-0.9	-1.4	-0.7	-0.2	0.2
Worry too long after embarrassment	0.6	1.0	3.6	-0.3	0.1	0.0	-1.0	-0.8	-1.9	-1.2	0.4	-0.4	-1.6	-0.5	-1.7
Shortness of breath walking on level ground	0.6	0.8	4.4	-0.7	-1.1	-1.0	-0.2	-0.1	0.5	-1.0	-2.1	-0.5	-0.8	0.1	0.1
Eye problems/disorders: None of the above	0.6	0.7	1.3	1.1	0.2	0.1	0.8	0.8	0.6	0.7	0.6	1.1	0.9	1.2	0.8
Commuting to job workplace: Walk	0.6	0.7	1.9	0.3	1.2	1.3	1.4	-0.1	-0.1	-0.2	1.1	-0.1	1.0	-0.9	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.3	-0.4	-1.5	-1.5	0.5	0.1	1.4	-0.1	-1.1	-0.4	-0.4	-1.1	0.9
Alcohol drinker status: Never	0.6	0.7	4.0	0.8	-0.4	-0.5	2.0	0.9	0.7	0.2	1.1	0.7	0.3	0.0	0.9
Ever depressed for a whole week	0.6	0.7	2.9	-1.1	-0.2	-0.5	-1.0	-0.8	-0.5	-1.0	-0.1	-0.8	-1.7	0.6	-0.6
Myopia	0.6	0.9	2.4	1.4	-0.0	-0.3	1.5	0.9	-0.2	0.8	1.5	1.4	0.2	0.2	0.2
Vascular/heart problems diagnosed by doctor	0.6	1.5	6.3	1.4	1.6	1.2	0.9	0.4	-1.1	0.3	2.5	1.1	0.8	1.5	-0.4
Age at First Birth	0.5	0.8	1.7	-0.7	0.6	0.6	-1.3	-1.2	-0.8	-0.5	-0.9	-0.8	-0.5	1.0	-1.1
Bipolar Disorder (2011)	0.5	0.5	1.7	-0.9	0.0	0.0	0.7	-1.3	0.9	-0.7	-0.8	-0.9	-0.1	-0.3	0.0
HDL Cholesterol	0.5	0.8	2.4	-0.9	-1.5	-1.3	0.7	-0.7	0.7	-0.6	-0.5	-0.5	-0.5	-1.1	1.0
Hand grip strength (left)	0.5	1.4	4.3	0.7	0.0	-0.3	-1.9	1.6	0.1	2.1	0.1	1.0	1.4	1.4	0.1
Sensitivity / hurt feelings	0.5	0.8	2.4	1.1	-0.4	-0.8	0.8	0.6	0.1	0.4	1.5	1.4	-0.3	1.3	0.5
Supplements: Zinc	0.5	0.6	1.2	-0.7	0.6	1.0	-0.9	-0.6	-0.5	-1.1	-0.9	-0.8	-0.7	-0.1	-0.6
Stomach or abdominal pain in last month	0.5	0.6	1.5	0.4	-0.8	-1.1	0.7	0.7	1.2	0.7	0.3	0.8	1.0	-0.3	0.7
Sitting height	0.5	3.7	8.3	1.4	-1.8	-2.9	2.4	1.2	2.5	2.0	0.9	2.1	0.5	1.8	2.3
Past tobacco smoking	0.5	0.9	2.9	0.2	1.5	0.9	1.3	-0.2	-0.4	-0.1	1.1	0.3	1.0	0.8	-1.7
Neuroticism score	0.5	1.1	3.2	-1.0	-1.2	-1.2	0.6	-1.0	0.5	-1.8	-0.8	-0.7	-1.8	-0.5	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	1.1	-0.1	-0.2	-0.3	0.9	-0.0	1.1	0.8	1.2	1.0	0.2	0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.2	-0.9	0.5	0.3	-0.8	-0.8	-0.8	-1.0	-0.2	-1.0	-1.5	0.4	-1.3
Qualifications: College or University degree	0.5	1.5	4.9	-0.1	2.2	2.2	-0.2	-0.9	-1.4	-0.5	1.9	-0.7	-0.1	0.2	-1.2
Migraine (self-reported)	0.5	0.6	1.9	-1.0	-0.8	-0.6	-0.2	-0.7	0.3	-0.9	-1.4	-0.7	-0.8	-0.9	0.1
Medication: Allopurinol	0.5	0.7	1.9	-0.3	1.4	1.3	0.0	-0.6	-0.8	-0.9	0.1	-0.8	-0.6	0.6	-1.1
Medication: Omeprazole	0.5	0.6	2.0	0.1	-1.1	-1.4	0.7	0.2	0.4	0.7	0.8	0.5	1.0	-1.1	0.2
Medication: Seretide 50 evohaler	0.5	0.6	2.0	-0.1	-1.4	-1.2	-0.9	0.9	-0.1	0.1	-0.9	0.2	-0.8	-0.5	0.7
Heart disease (mother)	0.5	0.5	3.6	-0.4	-0.3	-0.0	-1.2	0.1	0.7	0.6	-1.9	-0.3	-0.0	0.3	0.5
Average weekly red wine intake	0.5	0.8	2.7	-0.0	-1.4	-1.3	0.9	0.2	1.5	0.5	-0.1	0.2	-0.1	0.0	1.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	3.0	-0.3	-0.2	0.2	0.3	-0.6	-0.6	-1.4	0.4	-0.5	-1.7	-0.8	-0.1
Medication: Blood pressure	0.5	0.9	3.7	-0.2	-0.1	0.0	-1.8	0.6	0.9	1.0	-1.9	-0.2	1.2	-0.0	0.2
Average weekly beer plus cider intake	0.5	0.8	1.7	-0.6	0.4	0.5	-1.2	-1.0	-1.3	-1.2	-0.2	-0.5	-1.2	-0.1	-1.1
Irritability	0.5	0.8	1.9	-0.9	-1.3	-1.4	-0.0	-0.5	0.6	-0.7	-1.2	-0.5	-0.9	-1.3	0.2
Age started oral contraceptive pill	0.5	0.6	1.3	0.3	-1.2	-1.0	-0.2	1.1	1.0	0.9	-0.4	0.5	0.5	-0.7	0.9
Depressed Affect (Nagel 2018)	0.4	0.8	1.7	-0.7	-1.3	-1.2	0.1	-0.8	1.0	-1.1	-1.2	-0.5	-1.1	0.1	0.5
Neuroticism (Nagel 2018)	0.4	0.8	2.0	-0.9	-1.1	-1.2	0.3	-1.2	0.4	-1.4	-0.7	-0.7	-1.3	-0.3	-0.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	4.4	-0.9	1.0	1.1	-2.1	-0.6	-0.2	-0.2	-0.8	-0.9	0.2	0.3	-0.9
Systolic Blood Pressure	0.4	2.2	8.9	-1.5	0.2	0.7	-2.4	-0.3	-1.1	-1.2	-3.0	-1.5	-1.3	-0.1	-1.4
Neuroticism	0.4	1.0	2.1	-1.2	-0.9	-0.9	-0.2	-1.4	0.2	-1.5	-1.1	-0.9	-1.4	-0.5	-0.4
Average weekly spirits intake	0.4	0.5	2.2	-0.7	-0.0	-0.2	1.5	-1.1	0.7	-1.0	0.1	-0.8	-0.8	0.1	0.2
Relative age of first facial hair	0.4	0.9	2.3	0.0	1.3	1.5	0.1	-1.3	-1.1	-1.2	0.8	-0.4	0.1	0.4	-1.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.5	-0.4	-0.5	-0.6	1.2	-0.7	0.9	-0.6	-0.5	-0.4	0.1	-1.0	0.2
Chronic bronchitis/emphysema (father)	0.4	0.4	1.1	-0.8	0.2	0.5	-1.0	-0.2	-0.5	-0.3	-1.1	-0.9	-0.7	-0.6	-0.3
High blood pressure (mother)	0.4	0.5	1.2	0.9	1.1	0.7	-0.9	0.3	-0.2	0.4	-0.3	0.6	0.6	1.1	-0.6
Arm fat percentage (right)	0.4	1.5	3.8	-1.0	-1.7	-1.6	-0.7	-0.3	1.6	-0.3	-2.0	-0.5	-1.4	-0.1	1.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	5.3	0.2	-1.7	-2.3	1.4	0.2	1.1	0.6	0.9	0.6	-0.3	-0.6	0.9
Mouth/teeth dental problems: Dentures	0.4	0.7	3.1	-0.1	-0.9	-0.8	-1.8	-0.1	0.5	0.4	-1.5	0.1	-0.4	0.6	0.5
Illnesses of mother	0.4	0.5	2.7	-0.2	0.5	0.9	0.4	-0.1	-0.9	-0.5	1.6	-0.4	-0.1	-0.6	-0.3
Hair/balding pattern: Pattern 4	0.4	1.0	2.9	-1.7	-0.7	-0.7	-1.2	-0.7	0.2	-0.5	-1.4	-1.4	-1.1	-0.9	-0.3
Headache pain in last month	0.4	0.8	1.7	-0.8	-1.1	-1.2	0.1	-0.9	0.5	-0.9	-1.3	-0.5	-1.0	-0.9	0.4
Body fat percentage	0.4	1.7	6.1	-1.0	-1.7	-1.6	-1.0	-0.3	1.6	-0.2	-2.5	-0.6	-1.1	-0.0	1.6
Age at first live birth	0.4	0.7	1.3	-1.2	-0.9	-1.2	0.9	-0.6	0.9	-0.6	-0.8	-0.8	-0.6	-1.0	0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.4	2.1	-0.1	-0.0	-0.2	1.4	-0.2	0.6	-0.4	0.5	-0.2	-0.6	1.1	0.8
Hypertension (Self-reported)	0.4	1.1	5.7	-1.1	-1.0	-0.9	-0.9	-0.1	1.3	-0.1	-2.4	-0.8	-0.4	-0.8	0.2
Arm fat percentage (left)	0.4	1.8	4.3	-1.1	-1.9	-1.9	-0.3	-0.5	1.7	-0.4	-2.1	-0.6	-1.4	-0.4	1.7
Loneliness, isolation	0.4	0.6	1.8	-0.6	-1.1	-1.0	0.2	-0.5	0.4	-0.9	-0.6	-0.5	-1.3	0.2	0.6
Osteoarthritis (self-reported)	0.4	0.6	3.7	-0.8	-0.9	-0.5	-0.3	-0.1	-0.2	-0.1	-0.7	-0.7	-0.5	-1.9	0.1
Miserableness	0.4	0.7	1.6	-0.2	-0.9	-1.2	0.8	-0.5	1.2	-1.3	-0.5	-0.1	-0.9	0.6	0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.1	-0.1	0.8	0.6	-0.8	-0.2	-1.2	-0.4	0.1	-0.3	-0.5	0.8	-1.4
Medication: Atorvastatin	0.4	0.4	1.5	-0.5	-1.0	-0.8	-0.8	0.3	0.3	0.4	-0.8	-0.2	0.2	-1.2	0.4
Diastolic blood pressure, automated reading	0.4	1.2	3.8	-1.6	-0.6	-0.4	-0.3	-0.9	-0.8	-1.1	-1.9	-1.4	-1.4	-0.2	-1.1
Bipolar Disorder (2018)	0.3	0.5	3.8	-0.1	0.6	0.7	2.0	-0.3	0.2	-0.1	0.7	-0.4	-0.1	-0.6	0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	4.5	-0.7	-0.1	-0.1	-1.0	-0.1	0.4	0.1	-2.1	-0.5	0.4	-0.6	-0.0
Lung FEV1/FVC ratio	0.3	1.7	6.5	1.8	1.4	0.8	0.7	0.1	-1.3	1.0	2.6	1.6	1.3	0.7	-1.0
Tanning	0.3	3.4	20.1	-0.2	1.6	1.9	-4.5	0.2	-0.6	0.9	-2.4	-0.4	0.9	2.2	-1.5
Hearing difficulty/problems: Yes	0.3	0.4	1.2	0.9	0.4	0.5	-0.2	0.6	-0.2	0.9	0.5	0.9	1.1	0.1	0.0
Average weekly fortified wine intake	0.3	0.3	1.1	0.4	0.5	-0.3	0.3	0.1	-0.1	0.4	0.9	0.5	-0.0	1.1	-0.9
Maternal smoking around birth	0.3	0.5	2.1	0.6	0.6	0.6	-0.9	0.8	0.0	0.7	0.4	0.5	0.1	1.5	-0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.8	0.3	-0.7	-0.7	0.4	0.8	-0.1	0.5	0.8	0.4	0.2	-1.3	0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	0.6	-0.5	-0.5	1.1	0.2	0.1	-0.2	0.6	0.6	-0.6	-0.7	0.6
High blood pressure	0.3	0.9	4.3	-0.9	-1.1	-0.9	-0.9	0.1	1.0	0.1	-2.1	-0.6	-0.3	-0.9	0.3
Nervous feelings	0.3	0.6	2.0	1.3	-0.4	-0.6	0.6	1.1	0.4	0.8	0.8	1.4	0.5	0.6	0.3
Had menopause	0.3	0.4	1.1	1.0	-0.1	-0.0	-0.3	0.2	0.2	0.9	0.4	1.0	1.0	0.4	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	1.5	-0.5	0.2	0.6	0.1	-1.0	-0.8	-1.2	-0.1	-0.8	-0.9	-0.6	-0.5
Noisy workplace	0.3	0.4	1.3	-0.1	-0.8	-0.7	0.4	-0.2	0.8	-0.3	-0.8	-0.0	-0.6	0.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.8	-0.3	-1.6	-2.0	1.1	-0.5	1.0	0.0	0.4	0.0	-0.5	-0.8	0.8
Exposure to tobacco smoke at home	0.3	0.3	1.0	-0.5	-0.1	0.1	0.5	-0.5	-0.3	-1.0	0.4	-0.5	-0.9	-0.5	0.4
Glaucoma (self-reported)	0.3	0.3	2.1	0.2	0.4	0.2	0.7	-0.5	-0.7	0.2	1.4	0.4	0.1	-0.5	-0.3
High blood pressure (siblings)	0.3	0.4	2.2	-0.4	-0.4	-0.0	-0.5	0.1	0.7	-0.5	-1.5	-0.5	-1.0	-0.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	2.4	0.1	0.5	0.5	-1.6	-0.1	-0.9	0.2	-0.2	0.1	0.1	0.1	-0.7
Alcohol intake frequency.	0.3	0.6	1.3	0.5	-1.0	-1.1	1.0	0.4	1.0	0.1	0.2	0.6	1.0	-0.0	1.0
Leg pain on walking	0.3	0.4	1.2	-0.3	-0.1	-0.3	-0.5	-0.8	-0.3	-1.1	0.0	-0.2	-1.1	0.0	-1.0
Eye problems/disorders: Cataract	0.3	0.3	0.8	-0.6	-0.8	-0.7	-0.1	-0.3	-0.3	-0.5	-0.5	-0.6	-0.5	-0.9	-0.2
Osteoporosis (self-reported)	0.3	0.4	3.0	0.2	0.3	0.4	0.1	0.6	-1.0	0.3	1.7	0.1	-0.1	-0.4	-0.1
Medication: Bendroflumethiazide	0.3	0.5	1.4	-0.5	-1.2	-1.0	0.1	-0.2	0.9	-0.0	-0.8	-0.5	-0.0	-1.0	0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	0.3	-0.7	-1.0	0.2	0.1	0.1	0.8	0.8	0.6	1.1	-0.4	0.0
Heart attack/myocardial infarction (self-reported)	0.3	0.3	1.0	-0.4	-0.8	-1.0	-0.2	-0.1	1.0	-0.1	-1.0	-0.1	-0.1	0.4	-0.1
Worry (Nagel 2018)	0.2	0.4	1.1	-0.3	-0.9	-1.1	0.1	-0.6	0.4	-0.6	-0.9	-0.1	-0.7	0.2	-0.5
Reaction Time	0.2	0.4	1.3	-0.7	-1.1	-1.1	-0.0	-0.5	0.6	-0.3	-0.6	-0.4	-0.6	-0.4	0.5
Mean Putamen Volume	0.2	0.2	0.5	-0.5	0.2	0.5	0.3	-0.5	0.3	-0.5	-0.1	-0.7	-0.6	0.4	-0.0
LDL Cholesterol	0.2	0.3	1.2	-0.3	0.3	0.3	-1.1	0.2	-0.6	0.0	-0.6	-0.3	-0.8	0.5	-0.6
Triglycerides	0.2	0.3	0.8	0.9	0.7	0.8	-0.1	0.6	-0.1	0.5	0.4	0.4	0.8	0.5	0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.8	0.0	-0.6	-0.2	0.3	0.1	0.6	-0.4	-0.9	-0.4	-0.8	0.5	0.2
Height	0.2	4.6	16.2	2.9	0.9	-0.4	2.0	0.8	-0.1	2.0	4.0	3.1	0.6	3.4	-0.0
Diabetes (father)	0.2	0.2	1.4	-0.2	0.0	-0.1	0.1	-0.7	0.4	-0.6	-0.5	-0.1	-0.4	1.2	-0.1
Diabetes (mother)	0.2	0.3	1.6	-0.2	-0.6	-0.8	-0.3	-0.6	0.5	-0.3	-1.3	0.2	-0.1	0.3	0.2
Trunk fat percentage	0.2	1.0	2.9	-0.9	-1.1	-1.1	-0.9	-0.6	1.1	-0.4	-1.7	-0.6	-1.3	0.3	1.2
Supplements: Glucosamine	0.2	0.2	0.5	0.5	-0.0	0.0	0.3	0.6	-0.0	0.6	0.7	0.5	0.6	0.6	0.2
Heart attack	0.2	0.2	0.8	-0.3	-0.5	-0.8	-0.1	-0.1	0.9	-0.1	-0.7	-0.1	-0.1	0.6	-0.2
Fluid intelligence score	0.2	0.4	2.1	-0.2	0.9	0.8	-1.4	0.4	-0.0	0.5	-0.4	-0.2	0.5	0.2	-0.5
Number of live births	0.2	0.3	1.4	-0.4	-0.6	-0.6	0.0	-0.4	1.2	0.0	-0.4	-0.4	0.3	-0.3	0.5
Breastfed as a baby	0.2	0.3	0.6	0.2	-0.7	-0.7	0.7	0.2	0.3	-0.3	0.4	0.3	-0.6	-0.8	0.5
Loud music exposure frequency	0.2	0.3	0.8	-0.2	0.5	0.3	-0.3	-0.5	-0.2	-0.7	0.4	-0.3	-0.8	0.9	-0.3
Medication: Amlodipine	0.2	0.2	0.9	-0.2	-0.3	0.0	-0.3	0.2	0.5	0.0	-0.9	-0.3	0.0	-0.9	0.6
Birth weight	0.2	0.5	1.0	-0.7	-0.4	-0.4	0.8	-1.0	0.1	-1.0	-0.4	-0.7	-0.9	-0.7	0.4
Age at last live birth	0.2	0.3	0.8	-0.8	-0.0	-0.5	0.8	-0.9	0.8	-0.4	0.1	-0.7	-0.2	0.6	-0.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.8	-0.4	-0.1	-0.0	-0.2	-0.1	0.5	-0.2	-0.9	-0.5	-0.7	-0.7	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.9	-0.1	-0.7	-0.5	0.3	-0.2	-0.2	0.2	0.5	-0.0	0.1	-1.4	0.1
Smoking status: Previous	0.2	0.4	1.9	0.4	-0.6	-0.2	-1.4	0.5	0.1	0.5	-0.6	0.2	-0.5	0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.5	0.5	-0.7	-1.2	-0.2	0.3	0.7	0.4	-0.1	0.8	-0.1	1.1	0.2
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.6	-0.6	-0.9	0.2	-0.4	0.4	-0.2	-0.2	-0.3	-0.5	-0.9	-0.1
Medication for cholesterol	0.2	0.3	0.8	-0.2	0.4	0.3	0.7	-0.4	-0.4	-0.8	0.6	-0.3	-0.9	0.2	-0.5
Back pain experienced in last month	0.2	0.2	0.7	-0.5	-0.1	-0.2	0.5	-0.3	0.1	-0.6	0.6	-0.5	-0.8	0.7	-0.3
Illnesses of father: High blood pressure	0.2	0.2	0.6	-0.4	-0.7	-0.7	-0.1	0.1	0.7	0.1	-0.6	-0.1	-0.2	0.8	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.7	0.0	-0.2	-0.5	0.1	0.1	-0.1	-0.0	-0.2	0.3	-0.5	0.8	-0.3
Pack years adult smoking proportion	0.1	0.1	0.4	-0.6	-0.3	-0.2	0.1	-0.3	0.4	-0.4	-0.0	-0.2	-0.2	-0.4	0.4
Fed-up feelings	0.1	0.2	0.5	0.2	-0.7	-0.7	0.1	-0.3	0.4	-0.3	-0.2	0.4	-0.3	-0.4	0.4
Medication: Atenolol	0.1	0.2	0.4	-0.4	0.3	0.4	0.6	0.0	0.6	-0.4	-0.1	-0.6	-0.3	-0.3	-0.0
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.3	-0.1	0.1	-0.4	0.4	-0.3	0.4	0.2	0.2	0.3	-0.4	0.2
Forced vital capacity (FVC)	0.1	0.5	2.7	-0.2	-1.2	-1.6	0.4	-0.0	0.7	0.2	0.3	0.1	-1.1	-0.3	0.4
Qualifications: None of the above	0.1	0.1	0.4	0.3	-0.5	-0.2	-0.1	0.5	0.2	0.2	-0.1	0.3	0.6	-0.6	0.1
Worrier / anxious feelings	0.1	0.2	0.8	0.2	0.0	-0.3	0.7	0.2	-0.7	-0.2	0.9	0.3	-0.3	0.2	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.8	-0.3	0.9	0.7	-0.4	0.1	-0.4	0.2	0.4	-0.3	0.2	-0.2	-0.8
Length of working week for main job	0.1	0.1	0.5	-0.0	-0.2	-0.4	-0.4	-0.1	-0.2	0.0	-0.2	0.3	0.6	-0.7	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.3	1.5	-0.3	-0.9	-1.2	0.1	-0.2	0.6	-0.0	0.2	-0.1	-1.0	-0.1	0.5
Health satisfaction	0.1	0.2	0.7	-0.4	-0.1	-0.1	-0.1	-0.7	-0.1	-0.8	-0.4	-0.4	-0.3	-0.4	-0.5
Mean time to correctly identify matches	0.1	0.2	0.9	-0.2	-0.1	-0.1	-0.9	-0.3	-0.4	-0.1	-0.0	-0.2	-0.7	-0.1	-0.1
Pulse rate, automated reading	0.1	0.2	0.6	0.5	-0.5	-0.7	0.3	0.5	-0.6	0.6	0.1	0.8	0.0	0.6	0.2
Mineral and other dietary supplements	0.1	0.1	0.6	-0.2	0.4	0.1	-0.8	-0.5	-0.0	-0.1	-0.5	-0.1	0.0	-0.1	-0.6
Eye problems/disorders: Glaucoma	0.1	0.2	0.9	-0.2	-0.2	-0.2	0.3	0.0	0.3	0.6	0.4	-0.0	0.3	-0.9	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.6	-0.5	0.0	0.3	-0.0	-0.1	0.2	-0.3	-0.7	-0.8	-0.3	-0.0	0.0
Medication: Lisinopril	0.1	0.2	0.7	-0.2	0.1	-0.4	0.5	-0.0	0.8	-0.1	-0.6	-0.1	0.4	0.6	-0.2
Pain experienced in last month	0.1	0.2	0.5	0.1	0.7	0.7	0.3	-0.2	-0.2	0.1	0.7	0.0	0.4	-0.1	-0.3
Heart disease (siblings)	0.1	0.1	0.6	-0.3	-0.2	-0.2	-0.7	-0.3	0.2	-0.2	-0.7	-0.1	-0.3	-0.4	-0.4
Pack years of smoking	0.1	0.1	0.4	-0.6	-0.4	-0.1	0.1	-0.3	0.4	-0.4	-0.0	-0.2	-0.1	-0.6	0.5
Blood Platelet Count	0.0	0.3	1.1	-0.1	-0.2	0.0	-0.7	-0.5	-1.1	-0.5	0.5	-0.2	-0.6	-0.6	-0.0
Hair Pigment	0.0	1.3	3.0	-0.8	1.7	1.7	0.3	-1.1	-1.0	-1.4	0.2	-1.3	-0.5	-0.2	-1.5

Hub : Genes

KIAA0391

Models

Trait associations