Hub : Genes

KIAA0391

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0488 0.0202 1.6e-03 0.033 0.013 0.012 0.012 0.020 9.8e-06 4.5e-03 5.5e-03 5.8e-03 5.1e-04
2 NTR Blood 0.0517 0.0149 1.6e-12 0.050 0.046 0.048 0.045 0.049 1.2e-15 1.1e-14 2.4e-15 1.9e-14 2.4e-15
3 YFS Blood 0.2905 0.0371 0.0e+00 0.361 0.352 0.376 0.373 0.377 6.8e-125 3.1e-121 1.5e-131 2.9e-130 5.8e-132
4 TCGA Glioblastoma Multiforme 0.1990 0.0890 7.0e-03 -0.004 0.011 -0.003 NA 0.002 4.6e-01 1.5e-01 4.1e-01 NA 2.7e-01
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0944 0.0353 4.2e-06 0.065 0.060 0.065 NA 0.059 7.6e-08 2.5e-07 8.1e-08 NA 3.1e-07
6 TCGA Brain Lower Grade Glioma 0.0696 0.0286 5.1e-06 0.045 0.040 0.035 NA 0.038 7.6e-06 2.0e-05 6.2e-05 NA 3.2e-05
7 TCGA Lung Adenocarcinoma 0.0612 0.0250 3.5e-05 0.055 0.031 0.028 NA 0.038 4.6e-07 1.2e-04 2.7e-04 NA 2.5e-05
8 TCGA Lung Squamous Cell Carcinoma 0.0660 0.0297 7.2e-04 0.007 0.029 0.045 NA 0.041 4.4e-02 2.9e-04 6.5e-06 NA 1.6e-05
9 TCGA Ovarian Serous Cystadenocarcinoma 0.1150 0.0540 1.7e-03 0.039 -0.002 0.005 NA 0.030 1.1e-03 4.9e-01 1.4e-01 NA 3.8e-03
10 TCGA Pancreatic Adenocarcinoma 0.0980 0.0470 4.9e-03 0.090 0.051 0.080 NA 0.077 1.4e-04 3.5e-03 3.1e-04 NA 3.9e-04
11 TCGA Testicular Germ Cell Tumors 0.1820 0.0730 6.4e-04 0.147 0.077 0.138 NA 0.009 7.3e-06 1.1e-03 1.4e-05 NA 1.5e-01
12 TCGA Thyroid Carcinoma 0.1170 0.0380 2.1e-10 0.108 0.133 0.139 NA 0.132 1.3e-10 6.5e-13 2.0e-13 NA 8.4e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.3 0.5 3.8 -0.1 0.6 0.7 2.0 -0.3 0.2 -0.1 0.7 -0.4 -0.1 -0.6 0.3
Bipolar Disorder or Schizophrenia 2.3 5.6 14.1 -3.4 -0.1 0.6 0.5 -3.8 -0.7 -3.0 -2.0 -3.7 -2.7 -2.2 -0.9
Depressed Affect (Nagel 2018) 0.4 0.8 1.7 -0.7 -1.3 -1.2 0.1 -0.8 1.0 -1.1 -1.2 -0.5 -1.1 0.1 0.5
Depression (Nagel 2018) 2.3 3.4 9.0 -1.5 -3.0 -2.8 0.9 -0.9 2.1 -1.6 -1.8 -1.1 -2.1 -1.5 1.3
Intelligence (Savage-Jansen 2018) 0.7 2.0 3.8 -1.6 1.4 1.6 -1.8 -1.7 -1.2 -1.2 -0.8 -1.9 -0.9 0.3 -1.7
Neuroticism (Nagel 2018) 0.4 0.8 2.0 -0.9 -1.1 -1.2 0.3 -1.2 0.4 -1.4 -0.7 -0.7 -1.3 -0.3 -0.3
Schizophrenia (2018) 4.3 8.8 21.2 -4.4 -0.6 0.3 -0.9 -4.6 -1.1 -3.8 -3.2 -4.4 -3.4 -2.4 -1.4
Schizophrenia vs Biploar Disorder 3.7 4.9 10.5 -2.8 1.0 1.4 -1.0 -3.2 -1.8 -3.0 -1.6 -3.2 -2.4 -1.1 -1.9
Worry (Nagel 2018) 0.2 0.4 1.1 -0.3 -0.9 -1.1 0.1 -0.6 0.4 -0.6 -0.9 -0.1 -0.7 0.2 -0.5
Alzheimer’s Disease (in mother) 0.7 0.8 2.3 -0.4 -1.4 -1.5 0.2 0.3 0.9 0.6 -1.5 0.1 0.7 -1.1 0.7
Alzheimer’s Disease (in father) 2.9 3.2 7.5 -2.3 -2.3 -1.8 -0.4 -1.6 0.8 -1.8 -2.7 -1.9 -2.0 -1.1 1.0
Alzheimer’s Disease (including proxy) 1.1 1.6 5.3 -0.7 -2.0 -2.0 -0.1 0.3 1.6 0.6 -2.3 -0.3 0.4 -0.4 1.5
Crohns Disease (2017) 3.9 8.6 22.0 -3.8 -1.3 -0.8 -1.9 -4.0 -0.2 -3.7 -4.7 -3.7 -3.3 -2.1 -1.4
Irritable Bowel Disease (IBD) 3.4 8.2 28.4 -3.6 -2.2 -1.4 -1.3 -3.1 0.5 -3.4 -5.3 -3.4 -3.0 -2.4 0.1
Ulcerative Colitis (UC) 2.0 3.7 16.2 -2.1 -2.3 -1.5 -0.4 -1.1 1.1 -1.7 -4.0 -1.8 -1.7 -1.7 1.5
Major Depression (MDD) 1.1 1.3 2.5 -1.4 -1.5 -1.4 -0.2 -1.1 0.9 -1.1 -1.2 -0.9 -1.6 -1.2 0.4
Reaction Time 0.2 0.4 1.3 -0.7 -1.1 -1.1 -0.0 -0.5 0.6 -0.3 -0.6 -0.4 -0.6 -0.4 0.5
Verbal and Numeric Reasoning (VNR) 0.4 0.9 4.4 -0.9 1.0 1.1 -2.1 -0.6 -0.2 -0.2 -0.8 -0.9 0.2 0.3 -0.9
Breast Cancer 3.0 7.3 13.9 3.4 3.1 2.8 -0.2 2.8 -0.8 2.8 3.5 2.9 2.9 3.7 0.2
Ovarian Cancer 1.0 1.3 3.7 0.5 1.9 1.9 -0.6 -0.4 -1.2 -0.3 1.1 0.1 -0.1 1.9 -1.0
Prostate Cancer 0.6 0.8 4.2 0.5 0.6 0.4 -1.4 0.2 -2.0 0.2 0.1 0.6 -0.5 0.2 -1.4
Age at First Birth 0.5 0.8 1.7 -0.7 0.6 0.6 -1.3 -1.2 -0.8 -0.5 -0.9 -0.8 -0.5 1.0 -1.1
Bipolar Disorder (2011) 0.5 0.5 1.7 -0.9 0.0 0.0 0.7 -1.3 0.9 -0.7 -0.8 -0.9 -0.1 -0.3 0.0
Body Mass Index (BMI) (2010) 0.7 0.9 1.9 1.0 -0.9 -1.0 1.0 0.7 1.4 1.0 0.7 1.2 0.8 0.1 1.2
Coronary Artery Disease (CAD) 0.9 1.1 3.3 0.3 -1.1 -1.1 1.8 0.7 1.8 0.5 -0.6 0.5 1.0 0.1 1.1
Crohns Disease (2012) 3.0 4.8 10.3 -2.5 -0.3 -0.1 -2.1 -3.2 -1.1 -3.1 -2.5 -2.5 -3.1 -1.0 -1.7
Mean Putamen Volume 0.2 0.2 0.5 -0.5 0.2 0.5 0.3 -0.5 0.3 -0.5 -0.1 -0.7 -0.6 0.4 -0.0
Fasting Glucose 0.6 0.7 2.8 0.6 1.0 0.8 -0.4 -1.1 -1.2 -0.7 0.5 -0.2 -0.0 0.5 -1.7
HbA1C 0.6 0.7 2.3 -0.3 -0.8 -0.9 0.7 -0.1 1.0 -1.2 -0.4 -0.6 -1.5 0.6 0.6
HDL Cholesterol 0.5 0.8 2.4 -0.9 -1.5 -1.3 0.7 -0.7 0.7 -0.6 -0.5 -0.5 -0.5 -1.1 1.0
LDL Cholesterol 0.2 0.3 1.2 -0.3 0.3 0.3 -1.1 0.2 -0.6 0.0 -0.6 -0.3 -0.8 0.5 -0.6
Lupus 1.1 1.6 5.1 -0.2 -2.0 -2.3 1.0 -0.1 2.0 0.0 -1.6 0.4 -0.2 0.8 1.4
Neuroticism (2016) 2.1 3.1 6.1 -2.3 -1.8 -1.8 -0.8 -1.7 0.7 -2.0 -2.5 -2.0 -2.2 -1.3 -0.2
Primary Biliary Cirrhosis 2.8 4.0 9.0 -2.8 0.7 1.1 -1.3 -2.9 -0.6 -2.5 -2.6 -3.0 -2.2 -0.2 -1.3
Rheumatoid Arthritis 3.5 4.8 7.4 2.0 -1.8 -2.0 2.5 2.7 2.6 2.2 1.3 2.5 2.5 -0.1 2.5
Schizophrenia (2014) 4.7 10.4 25.4 -4.7 0.2 1.1 -0.5 -5.0 -1.7 -4.1 -2.8 -4.9 -3.8 -2.6 -1.8
Triglycerides 0.2 0.3 0.8 0.9 0.7 0.8 -0.1 0.6 -0.1 0.5 0.4 0.4 0.8 0.5 0.1
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.8 0.0 -0.6 -0.2 0.3 0.1 0.6 -0.4 -0.9 -0.4 -0.8 0.5 0.2
Ulcerative Colitis 0.7 1.0 3.5 -1.4 -0.8 -0.3 -0.2 -0.8 0.3 -1.1 -1.9 -1.3 -1.1 -0.7 0.7
Blood Eosinophil Count 1.7 13.0 48.4 4.7 1.1 0.9 -0.7 7.0 1.5 5.3 1.8 4.3 3.4 4.0 1.9
Blood Platelet Count 0.0 0.3 1.1 -0.1 -0.2 0.0 -0.7 -0.5 -1.1 -0.5 0.5 -0.2 -0.6 -0.6 -0.0
Blood Red Count 0.6 5.6 17.4 0.5 3.5 2.7 -4.2 0.3 -2.3 1.1 0.6 0.2 -0.4 3.0 -3.6
Blood White Count 3.2 23.4 53.5 -3.5 5.2 6.3 -7.3 -3.6 -6.0 -4.1 -2.4 -4.7 -4.3 0.1 -5.9
Heel T-Score 0.9 6.8 21.2 1.1 4.0 2.5 -4.0 1.7 -0.2 1.6 -2.0 0.4 1.2 4.6 -3.2
BMI 1.8 10.4 27.7 0.9 -4.7 -4.9 1.2 2.3 4.9 2.6 -2.7 2.0 1.0 -0.0 5.3
Height 0.2 4.6 16.2 2.9 0.9 -0.4 2.0 0.8 -0.1 2.0 4.0 3.1 0.6 3.4 -0.0
Waist Hip Ratio (WHR) 0.7 3.0 7.8 2.5 0.5 0.4 0.3 2.6 -0.0 2.3 2.0 2.3 2.8 0.4 0.6
Systolic Blood Pressure 0.4 2.2 8.9 -1.5 0.2 0.7 -2.4 -0.3 -1.1 -1.2 -3.0 -1.5 -1.3 -0.1 -1.4
Smoking Status 1.0 2.4 4.7 -2.1 -1.1 -0.4 -0.7 -1.6 0.4 -1.7 -1.9 -2.1 -2.2 -1.6 0.9
Allergy or Eczema 6.2 16.4 43.0 5.9 2.1 1.2 1.9 5.1 -0.9 4.9 6.6 5.7 3.8 3.5 0.8
Cardiovascular Disease 0.8 2.6 12.2 -1.7 -2.1 -1.8 -1.4 0.1 1.7 -0.3 -3.5 -1.0 -0.8 -1.5 0.6
Hypothyroidism (self reported) 2.5 5.6 11.1 -3.2 -1.1 -0.3 -3.3 -2.5 -1.1 -2.7 -3.3 -3.0 -2.2 -1.9 -1.4
Respiratory disease 1.3 2.8 8.0 2.5 0.8 1.0 -1.2 2.8 -0.7 1.8 2.2 2.3 0.7 1.0 0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.6 4.5 -0.7 -0.1 -0.1 -1.0 -0.1 0.4 0.1 -2.1 -0.5 0.4 -0.6 -0.0
Lung FEV1/FVC ratio 0.3 1.7 6.5 1.8 1.4 0.8 0.7 0.1 -1.3 1.0 2.6 1.6 1.3 0.7 -1.0
Lung FVC 1.3 6.5 13.8 -3.4 -2.0 -1.1 -2.4 -2.3 -1.2 -2.5 -2.4 -3.2 -3.7 -3.5 -0.9
Neuroticism 0.4 1.0 2.1 -1.2 -0.9 -0.9 -0.2 -1.4 0.2 -1.5 -1.1 -0.9 -1.4 -0.5 -0.4
Chronotype (morning person) 0.8 1.9 10.0 1.5 -0.0 -0.1 0.2 1.5 1.2 1.9 0.3 1.5 3.2 0.5 0.9
Hair Pigment 0.0 1.3 3.0 -0.8 1.7 1.7 0.3 -1.1 -1.0 -1.4 0.2 -1.3 -0.5 -0.2 -1.5
Tanning 0.3 3.4 20.1 -0.2 1.6 1.9 -4.5 0.2 -0.6 0.9 -2.4 -0.4 0.9 2.2 -1.5
Hand grip strength (left) 0.5 1.4 4.3 0.7 0.0 -0.3 -1.9 1.6 0.1 2.1 0.1 1.0 1.4 1.4 0.1
Number of treatments/medications taken 0.7 1.2 4.3 -1.1 -1.2 -0.7 -1.1 0.3 0.5 -0.3 -2.0 -1.0 -0.8 -2.1 0.5
Average weekly spirits intake 0.4 0.5 2.2 -0.7 -0.0 -0.2 1.5 -1.1 0.7 -1.0 0.1 -0.8 -0.8 0.1 0.2
Sensitivity / hurt feelings 0.5 0.8 2.4 1.1 -0.4 -0.8 0.8 0.6 0.1 0.4 1.5 1.4 -0.3 1.3 0.5
Frequency of depressed mood in last 2 weeks 3.7 5.2 12.8 -1.9 -3.6 -3.4 1.5 -1.5 2.5 -2.1 -2.1 -1.4 -2.3 -2.1 2.0
Hearing difficulty/problems: Yes 0.3 0.4 1.2 0.9 0.4 0.5 -0.2 0.6 -0.2 0.9 0.5 0.9 1.1 0.1 0.0
Relative age of first facial hair 0.4 0.9 2.3 0.0 1.3 1.5 0.1 -1.3 -1.1 -1.2 0.8 -0.4 0.1 0.4 -1.3
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.9 -0.9 -1.2 -1.0 -0.4 -0.8 0.4 -0.7 -1.7 -0.7 -0.6 -1.4 0.2
Ever used hormone-replacement therapy (HRT) 1.1 1.4 4.3 0.3 -2.0 -1.6 1.0 0.4 0.5 0.2 1.0 0.5 -0.6 -2.1 1.5
Ever had hysterectomy (womb removed) 0.6 0.7 2.9 -1.1 -0.6 0.2 -0.7 -0.3 0.0 -0.6 -1.2 -1.1 -0.2 -1.7 -0.1
Systolic blood pressure, automated reading 0.6 1.8 7.0 -1.1 0.5 0.9 -2.5 -0.2 -1.3 -0.4 -2.6 -1.1 -0.8 0.3 -1.6
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.7 0.0 -0.2 -0.5 0.1 0.1 -0.1 -0.0 -0.2 0.3 -0.5 0.8 -0.3
Angina 1.2 1.6 4.9 1.5 -0.3 -0.4 -0.4 2.2 0.2 2.2 0.8 1.7 1.6 -0.1 0.8
Medication for hormone replacement therapy 1.2 1.3 4.8 1.7 0.2 0.2 1.6 1.1 -0.3 0.5 2.2 1.6 0.7 -0.3 0.8
Vitamin and mineral supplements 0.7 1.0 2.2 0.7 -0.7 -0.9 -0.5 1.1 1.5 1.2 -1.2 0.9 1.4 0.6 0.4
Supplements: Zinc 0.5 0.6 1.2 -0.7 0.6 1.0 -0.9 -0.6 -0.5 -1.1 -0.9 -0.8 -0.7 -0.1 -0.6
Medication: Co-codamol 0.9 1.1 2.0 -1.3 -0.8 -0.6 -0.3 -1.0 -0.4 -1.4 -1.2 -1.3 -1.0 -1.4 -0.8
Medication: Metformin 0.7 1.0 3.6 -1.5 -0.8 -0.6 -0.1 -1.1 0.8 -0.8 -1.9 -1.2 -0.3 -1.1 0.4
Diabetes (father) 0.2 0.2 1.4 -0.2 0.0 -0.1 0.1 -0.7 0.4 -0.6 -0.5 -0.1 -0.4 1.2 -0.1
Diabetes (mother) 0.2 0.3 1.6 -0.2 -0.6 -0.8 -0.3 -0.6 0.5 -0.3 -1.3 0.2 -0.1 0.3 0.2
Severe depression (siblings) 1.2 1.4 4.6 -0.4 -2.1 -1.6 0.5 0.3 1.1 -0.2 -0.6 -0.1 -0.8 -2.1 1.5
Pack years adult smoking proportion 0.1 0.1 0.4 -0.6 -0.3 -0.2 0.1 -0.3 0.4 -0.4 -0.0 -0.2 -0.2 -0.4 0.4
Impedance of leg (right) 1.5 7.5 25.6 0.1 4.9 5.1 -2.6 -0.4 -3.3 -0.7 1.6 -0.9 0.4 2.4 -3.6
Leg fat-free mass (left) 2.2 11.7 33.6 1.7 -4.9 -5.8 3.1 2.1 4.8 2.9 -0.3 2.9 0.9 0.1 5.0
Trunk fat percentage 0.2 1.0 2.9 -0.9 -1.1 -1.1 -0.9 -0.6 1.1 -0.4 -1.7 -0.6 -1.3 0.3 1.2
Hand grip strength (right) 1.4 3.7 12.0 1.8 -0.8 -1.0 -1.5 3.1 0.6 3.5 0.2 2.4 2.7 1.0 1.3
Townsend deprivation index at recruitment 0.6 0.8 2.1 -0.7 -1.4 -1.0 -0.4 -0.5 0.9 -0.9 -0.6 -0.5 -0.6 -1.4 1.0
Current tobacco smoking 0.6 1.0 2.4 -1.4 0.0 0.5 -0.1 -1.4 -0.5 -1.5 -0.2 -1.5 -1.6 -0.6 -0.1
Average weekly fortified wine intake 0.3 0.3 1.1 0.4 0.5 -0.3 0.3 0.1 -0.1 0.4 0.9 0.5 -0.0 1.1 -0.9
Maternal smoking around birth 0.3 0.5 2.1 0.6 0.6 0.6 -0.9 0.8 0.0 0.7 0.4 0.5 0.1 1.5 -0.1
Fed-up feelings 0.1 0.2 0.5 0.2 -0.7 -0.7 0.1 -0.3 0.4 -0.3 -0.2 0.4 -0.3 -0.4 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.2 7.8 -0.8 -2.8 -2.4 0.5 -0.2 1.4 -0.8 -1.5 -0.4 -1.2 -1.6 1.5
Relative age voice broke 0.8 1.2 3.9 -0.2 1.7 2.0 -0.9 -1.1 -1.3 -0.8 0.4 -0.7 0.3 0.4 -1.6
Taking other prescription medications 1.7 2.6 8.9 -2.0 -1.2 -0.5 -1.7 -1.4 -0.3 -1.4 -2.2 -1.9 -1.2 -3.0 -0.3
Age when periods started (menarche) 1.5 3.6 10.3 0.0 2.7 3.1 -3.2 -0.1 -2.7 -0.6 -0.2 -1.0 -0.9 0.5 -2.5
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.8 0.3 -0.7 -0.7 0.4 0.8 -0.1 0.5 0.8 0.4 0.2 -1.3 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 8.4 1.5 1.1 0.1 0.6 2.2 1.4 2.0 -0.2 1.4 1.6 2.9 -0.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.1 0.6 -0.5 -0.5 1.1 0.2 0.1 -0.2 0.6 0.6 -0.6 -0.7 0.6
Qualifications: CSEs or equivalent 0.6 0.8 2.6 0.7 -1.2 -1.6 0.8 0.1 1.0 0.6 0.1 1.2 0.8 0.9 0.9
Serious illness, injury or assault to yourself 1.5 1.8 5.9 0.5 -1.9 -1.8 1.2 0.6 2.1 0.7 -0.6 0.8 1.2 -0.2 2.4
High blood pressure 0.3 0.9 4.3 -0.9 -1.1 -0.9 -0.9 0.1 1.0 0.1 -2.1 -0.6 -0.3 -0.9 0.3
Hayfever, allergic rhinitis or eczema 7.8 17.0 45.4 5.8 2.9 1.8 1.4 4.9 -1.1 4.8 6.7 5.6 3.8 4.2 0.2
Multivitamins +/- minerals 0.8 1.0 2.1 -0.7 0.6 1.0 1.0 -1.2 -1.0 -1.4 1.0 -1.0 -1.3 -1.0 -0.3
Stomach or abdominal pain in last month 0.5 0.6 1.5 0.4 -0.8 -1.1 0.7 0.7 1.2 0.7 0.3 0.8 1.0 -0.3 0.7
Supplements: Glucosamine 0.2 0.2 0.5 0.5 -0.0 0.0 0.3 0.6 -0.0 0.6 0.7 0.5 0.6 0.6 0.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.5 -0.4 -0.5 -0.6 1.2 -0.7 0.9 -0.6 -0.5 -0.4 0.1 -1.0 0.2
Medication: Atenolol 0.1 0.2 0.4 -0.4 0.3 0.4 0.6 0.0 0.6 -0.4 -0.1 -0.6 -0.3 -0.3 -0.0
Medication: Levothyroxine sodium 4.5 7.7 11.9 -3.4 -1.7 -1.0 -3.1 -3.2 -2.0 -3.4 -3.3 -3.2 -2.9 -3.0 -1.9
Sitting height 0.5 3.7 8.3 1.4 -1.8 -2.9 2.4 1.2 2.5 2.0 0.9 2.1 0.5 1.8 2.3
Chronic bronchitis/emphysema (father) 0.4 0.4 1.1 -0.8 0.2 0.5 -1.0 -0.2 -0.5 -0.3 -1.1 -0.9 -0.7 -0.6 -0.3
High blood pressure (mother) 0.4 0.5 1.2 0.9 1.1 0.7 -0.9 0.3 -0.2 0.4 -0.3 0.6 0.6 1.1 -0.6
Body mass index (BMI) 1.4 6.1 17.4 -0.3 -4.2 -4.1 0.5 0.9 3.5 1.2 -2.8 0.7 -0.1 -1.1 3.7
Impedance of leg (left) 1.2 6.1 19.6 -0.4 4.1 4.4 -2.8 -0.9 -3.1 -1.2 0.8 -1.3 -0.0 1.7 -3.3
Leg predicted mass (left) 2.3 11.9 33.9 1.7 -4.9 -5.8 3.2 2.2 4.9 2.9 -0.3 3.0 1.0 0.1 5.1
Trunk fat mass 0.6 2.6 7.5 0.2 -2.3 -2.7 0.3 0.6 2.6 1.0 -1.5 0.7 -0.4 0.6 2.7
Waist circumference 1.5 5.4 13.6 1.3 -3.4 -3.7 1.4 2.0 3.1 2.2 -0.3 2.1 0.7 -0.1 3.6
Number of incorrect matches in round 0.6 1.0 3.0 -0.2 1.7 1.7 -0.0 -0.8 -1.2 -1.0 0.6 -0.7 -0.5 0.1 -1.4
Past tobacco smoking 0.5 0.9 2.9 0.2 1.5 0.9 1.3 -0.2 -0.4 -0.1 1.1 0.3 1.0 0.8 -1.7
Alcohol usually taken with meals 2.5 4.1 12.9 2.7 1.2 0.9 1.3 2.3 -0.3 2.6 3.6 2.2 2.0 1.6 1.0
Nervous feelings 0.3 0.6 2.0 1.3 -0.4 -0.6 0.6 1.1 0.4 0.8 0.8 1.4 0.5 0.6 0.3
Frequency of tenseness / restlessness in last 2 weeks 3.2 5.0 14.7 -1.2 -3.8 -3.7 1.8 -0.6 3.1 -0.8 -1.8 -0.6 -0.8 -2.2 2.6
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.3 -0.1 0.1 -0.4 0.4 -0.3 0.4 0.2 0.2 0.3 -0.4 0.2
Hair/balding pattern: Pattern 2 0.6 0.7 2.2 0.2 -1.0 -1.1 0.9 0.9 1.4 0.6 0.4 0.4 0.4 -0.5 1.5
Had menopause 0.3 0.4 1.1 1.0 -0.1 -0.0 -0.3 0.2 0.2 0.9 0.4 1.0 1.0 0.4 0.2
Had other major operations 1.9 2.3 7.8 -0.6 -2.6 -2.2 1.0 -0.3 1.3 0.2 -0.9 -0.3 0.5 -2.8 2.0
Forced vital capacity (FVC) 0.1 0.5 2.7 -0.2 -1.2 -1.6 0.4 -0.0 0.7 0.2 0.3 0.1 -1.1 -0.3 0.4
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.7 4.4 1.2 0.4 -0.7 0.2 2.1 1.6 1.8 -0.8 1.3 1.4 2.0 0.0
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 4.4 -1.9 0.1 0.1 0.5 -1.6 0.3 -2.1 -0.8 -2.0 -1.8 -1.0 -0.4
Qualifications: None of the above 0.1 0.1 0.4 0.3 -0.5 -0.2 -0.1 0.5 0.2 0.2 -0.1 0.3 0.6 -0.6 0.1
Financial difficulties in last 2 years 0.9 1.3 2.6 -1.6 -0.5 -0.5 -1.6 -1.4 -0.6 -1.4 -1.0 -1.1 -1.4 -0.1 -1.0
Mouth/teeth dental problems 0.7 1.1 4.0 1.1 0.7 0.4 1.7 1.0 0.1 0.8 2.0 1.1 1.0 0.3 0.2
Heart attack 0.2 0.2 0.8 -0.3 -0.5 -0.8 -0.1 -0.1 0.9 -0.1 -0.7 -0.1 -0.1 0.6 -0.2
Allergy 5.8 13.3 31.4 -5.1 -1.6 -0.7 -1.6 -4.9 -0.3 -4.4 -5.6 -5.0 -3.6 -3.4 -1.4
Pain all over the body in last month 0.7 0.7 1.7 -1.0 0.2 0.3 -0.2 -1.0 -0.9 -1.2 -1.3 -1.0 -0.7 -0.2 -1.2
Diabetes (self-reported) 0.6 1.0 6.0 -0.4 -1.2 -1.2 -1.2 0.1 1.1 0.4 -2.4 -0.0 -0.2 -0.1 0.6
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 6.6 2.0 1.2 1.0 -0.7 1.9 -1.2 2.0 2.6 1.8 1.0 1.9 -0.3
Medication: Ramipril 1.0 1.2 3.4 0.5 -1.4 -1.5 1.0 1.2 1.8 1.1 -0.6 0.8 0.6 -0.4 1.4
Medication: Simvastatin 1.4 2.1 8.7 -1.4 -2.0 -1.6 -0.2 -0.6 1.7 -0.6 -3.0 -1.1 -0.7 -1.4 1.0
Fluid intelligence score 0.2 0.4 2.1 -0.2 0.9 0.8 -1.4 0.4 -0.0 0.5 -0.4 -0.2 0.5 0.2 -0.5
Illnesses of siblings 0.8 1.1 5.9 0.4 1.4 1.1 0.8 -0.5 -1.4 0.0 2.4 0.2 0.4 0.3 -0.8
Neuroticism score 0.5 1.1 3.2 -1.0 -1.2 -1.2 0.6 -1.0 0.5 -1.8 -0.8 -0.7 -1.8 -0.5 -0.0
Weight 1.8 8.7 23.1 1.4 -4.2 -4.8 1.7 2.1 4.3 2.7 -1.1 2.5 0.8 0.4 4.5
Impedance of arm (right) 2.9 13.4 39.3 -0.3 6.3 6.0 -1.7 -2.2 -4.6 -2.4 3.9 -1.6 -1.2 2.7 -4.8
Arm fat percentage (right) 0.4 1.5 3.8 -1.0 -1.7 -1.6 -0.7 -0.3 1.6 -0.3 -2.0 -0.5 -1.4 -0.1 1.5
Trunk fat-free mass 3.0 17.1 35.9 3.1 -4.9 -6.0 3.4 3.8 5.6 4.5 0.0 4.4 2.5 0.9 5.7
Hip circumference 0.6 2.5 8.9 0.2 -2.5 -3.0 0.9 0.1 2.3 0.8 -0.4 0.9 -0.9 0.5 2.4
Time employed in main current job 1.0 1.1 3.2 0.2 -1.6 -1.5 0.2 1.3 0.8 0.9 -1.8 0.4 0.4 -0.5 1.4
Alcohol intake versus 10 years previously 0.7 1.0 2.5 -1.0 0.3 0.8 -1.4 -1.0 -1.6 -1.0 -0.6 -1.1 -0.6 -0.8 -1.3
Father’s age at death 1.7 2.3 5.9 -0.6 2.2 2.4 -1.4 -0.9 -2.2 -1.1 0.1 -1.2 -1.3 0.7 -2.0
Worrier / anxious feelings 0.1 0.2 0.8 0.2 0.0 -0.3 0.7 0.2 -0.7 -0.2 0.9 0.3 -0.3 0.2 -0.4
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 4.3 -1.4 -1.8 -1.6 0.1 -1.2 0.0 -1.7 -1.1 -0.9 -1.4 -2.1 0.4
Falls in the last year 1.0 1.3 3.1 -0.8 -1.0 -0.7 1.8 -1.5 0.8 -1.6 -0.0 -0.9 -1.2 -1.6 0.5
Hair/balding pattern: Pattern 3 0.3 0.5 1.5 -0.5 0.2 0.6 0.1 -1.0 -0.8 -1.2 -0.1 -0.8 -0.9 -0.6 -0.5
Number of live births 0.2 0.3 1.4 -0.4 -0.6 -0.6 0.0 -0.4 1.2 0.0 -0.4 -0.4 0.3 -0.3 0.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.2 5.3 0.2 -1.7 -2.3 1.4 0.2 1.1 0.6 0.9 0.6 -0.3 -0.6 0.9
Pulse rate 1.4 2.3 7.3 0.3 -2.6 -2.7 1.7 0.9 1.7 1.0 -0.6 1.1 0.7 -1.0 1.8
Happiness 2.3 2.8 6.6 -2.0 0.3 0.4 -1.2 -2.0 -1.2 -2.3 -1.3 -2.2 -2.6 -0.8 -1.7
Noisy workplace 0.3 0.4 1.3 -0.1 -0.8 -0.7 0.4 -0.2 0.8 -0.3 -0.8 -0.0 -0.6 0.3 1.1
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.8 -0.3 0.9 0.7 -0.4 0.1 -0.4 0.2 0.4 -0.3 0.2 -0.2 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.4 1.1 -0.1 -0.2 -0.3 0.9 -0.0 1.1 0.8 1.2 1.0 0.2 0.5
Mouth/teeth dental problems: Dentures 0.4 0.7 3.1 -0.1 -0.9 -0.8 -1.8 -0.1 0.5 0.4 -1.5 0.1 -0.4 0.6 0.5
Asthma 1.6 3.1 9.0 2.6 -0.2 -0.1 -0.8 3.0 0.4 2.3 1.4 2.6 1.6 1.1 1.5
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 4.2 -0.9 -0.4 0.0 -2.1 -0.5 -0.7 -0.5 -1.9 -0.9 -1.2 0.4 -0.6
Medication: Cholesterol lowering 0.7 1.1 4.8 -0.3 -1.3 -1.2 -0.2 1.0 1.6 0.8 -2.2 -0.0 0.3 -0.4 0.9
Depression (self-reported) 4.6 5.6 12.2 -2.9 -2.7 -2.2 0.8 -2.1 0.6 -2.6 -2.2 -2.6 -3.5 -2.9 1.4
Medication: Lansoprazole 0.9 1.0 3.8 -1.2 -0.1 -0.3 0.9 -1.9 -0.2 -1.6 -0.3 -1.1 -0.8 -0.8 -0.6
Prospective memory result 0.7 0.9 2.3 0.8 1.3 0.7 0.2 0.8 -0.8 1.0 1.5 0.8 1.1 0.9 -1.0
Lung cancer (father) 1.3 1.5 4.7 -1.2 -1.4 -1.1 0.3 -1.2 0.5 -1.2 -1.7 -1.0 -1.2 -2.2 0.3
Illnesses of mother 0.4 0.5 2.7 -0.2 0.5 0.9 0.4 -0.1 -0.9 -0.5 1.6 -0.4 -0.1 -0.6 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.8 -0.3 -1.6 -2.0 1.1 -0.5 1.0 0.0 0.4 0.0 -0.5 -0.8 0.8
Pulse wave Arterial Stiffness index 1.4 1.6 3.6 1.7 0.7 0.4 -0.6 1.5 -0.5 1.9 1.2 1.7 1.4 1.8 -0.1
Impedance of arm (left) 2.6 12.0 30.2 -0.9 5.5 5.4 -1.3 -2.9 -4.6 -3.0 3.3 -2.1 -1.8 1.6 -4.7
Arm fat mass (right) 0.8 3.4 9.8 0.0 -2.9 -3.1 0.4 0.7 2.9 0.9 -1.8 0.7 -0.6 0.1 2.9
Trunk predicted mass 3.0 17.4 36.6 3.1 -5.0 -6.0 3.4 3.8 5.6 4.5 0.0 4.4 2.5 0.9 5.7
Standing height 0.8 7.6 16.0 3.6 -0.5 -1.9 2.5 2.5 2.0 3.4 3.2 4.0 2.0 3.1 2.2
Length of working week for main job 0.1 0.1 0.5 -0.0 -0.2 -0.4 -0.4 -0.1 -0.2 0.0 -0.2 0.3 0.6 -0.7 -0.2
Exposure to tobacco smoke at home 0.3 0.3 1.0 -0.5 -0.1 0.1 0.5 -0.5 -0.3 -1.0 0.4 -0.5 -0.9 -0.5 0.4
Breastfed as a baby 0.2 0.3 0.6 0.2 -0.7 -0.7 0.7 0.2 0.3 -0.3 0.4 0.3 -0.6 -0.8 0.5
Tense / ‘highly strung’ 2.4 4.0 7.7 -2.5 -2.6 -2.4 0.5 -1.7 1.7 -1.9 -2.8 -1.8 -2.0 -1.5 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 6.6 -0.2 -2.6 -2.4 1.3 0.3 1.5 -0.1 -0.2 0.2 -1.2 -1.2 2.0
Hair/balding pattern: Pattern 4 0.4 1.0 2.9 -1.7 -0.7 -0.7 -1.2 -0.7 0.2 -0.5 -1.4 -1.4 -1.1 -0.9 -0.3
Birth weight of first child 0.9 1.6 2.7 -1.5 -1.3 -1.4 -0.3 -1.4 0.2 -1.4 -1.5 -1.3 -1.6 -1.4 -0.3
Peak expiratory flow (PEF) 1.0 2.3 4.5 1.4 -1.4 -2.1 1.3 1.7 1.0 1.8 2.1 1.9 0.7 0.2 1.2
Pulse wave reflection index 1.0 1.2 3.0 1.0 1.7 1.7 -0.9 0.4 -1.3 0.9 0.9 0.7 0.8 1.3 -0.9
Ever highly irritable/argumentative for 2 days 1.9 2.3 5.8 -2.0 -0.8 -0.9 0.7 -2.4 0.2 -2.4 -1.0 -1.7 -2.3 -0.7 -0.4
Loud music exposure frequency 0.2 0.3 0.8 -0.2 0.5 0.3 -0.3 -0.5 -0.2 -0.7 0.4 -0.3 -0.8 0.9 -0.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.2 -0.9 0.5 0.3 -0.8 -0.8 -0.8 -1.0 -0.2 -1.0 -1.5 0.4 -1.3
Mouth/teeth dental problems: Bleeding gums 5.8 7.5 15.6 -3.8 -0.1 0.5 -2.0 -3.6 -1.5 -3.6 -3.4 -4.0 -2.9 -1.7 -2.3
Blood clot in the leg (DVT) 4.3 5.6 15.7 0.8 -3.0 -3.2 3.2 1.2 4.0 1.4 -0.2 1.5 1.7 -0.3 3.7
Medication: Paracetamol 1.1 1.8 4.6 -1.6 -0.7 -0.7 -1.8 -1.4 -0.6 -1.5 -2.1 -1.3 -1.8 -0.3 -1.3
Headache pain in last month 0.4 0.8 1.7 -0.8 -1.1 -1.2 0.1 -0.9 0.5 -0.9 -1.3 -0.5 -1.0 -0.9 0.4
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 6.7 1.1 1.9 1.7 -0.3 -0.2 -1.9 0.1 2.6 0.6 0.6 0.9 -0.8
Glaucoma (self-reported) 0.3 0.3 2.1 0.2 0.4 0.2 0.7 -0.5 -0.7 0.2 1.4 0.4 0.1 -0.5 -0.3
Gout (self-reported) 0.6 0.8 2.8 -0.9 0.6 1.0 0.5 -1.0 0.2 -1.7 -0.9 -1.4 -0.7 -0.2 0.2
Hypothyroidism/myxoedema (self-reported) 3.3 6.5 10.8 -3.1 -0.4 0.3 -3.3 -3.1 -2.1 -3.3 -2.8 -3.2 -2.6 -1.9 -2.1
Medication: Amlodipine 0.2 0.2 0.9 -0.2 -0.3 0.0 -0.3 0.2 0.5 0.0 -0.9 -0.3 0.0 -0.9 0.6
Medication: Ventolin 100micrograms inhaler 1.6 2.0 5.4 2.1 1.0 0.6 -1.0 2.3 -0.7 1.8 1.4 2.1 1.2 0.7 -0.2
Birth weight 0.2 0.5 1.0 -0.7 -0.4 -0.4 0.8 -1.0 0.1 -1.0 -0.4 -0.7 -0.9 -0.7 0.4
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.8 0.5 -1.7 -1.5 0.3 0.3 1.1 0.5 -0.5 0.6 -0.3 -0.1 1.5
High blood pressure (siblings) 0.3 0.4 2.2 -0.4 -0.4 -0.0 -0.5 0.1 0.7 -0.5 -1.5 -0.5 -1.0 -0.3 0.5
Forced vital capacity (FVC), Best measure 0.1 0.3 1.5 -0.3 -0.9 -1.2 0.1 -0.2 0.6 -0.0 0.2 -0.1 -1.0 -0.1 0.5
Body fat percentage 0.4 1.7 6.1 -1.0 -1.7 -1.6 -1.0 -0.3 1.6 -0.2 -2.5 -0.6 -1.1 -0.0 1.6
Leg fat percentage (right) 0.7 2.4 7.5 -0.6 -2.2 -2.0 -1.0 0.7 2.2 1.0 -2.7 0.0 0.2 -0.1 2.2
Arm fat-free mass (right) 3.2 16.4 44.0 1.9 -5.8 -6.6 3.3 2.9 5.8 3.6 -1.5 3.3 1.6 -0.0 5.8
Exposure to tobacco smoke outside home 0.8 1.1 3.2 -1.0 0.5 0.6 0.5 -1.4 -1.2 -1.8 0.5 -1.3 -1.4 -0.9 -0.8
Comparative body size at age 10 0.8 2.2 6.2 0.9 -1.5 -1.7 0.5 1.3 2.5 1.4 -1.0 1.4 0.6 1.5 2.1
Number of full brothers 0.7 0.8 3.8 -0.3 -1.2 -1.1 1.0 0.1 1.1 -0.1 -0.5 -0.3 0.6 -1.9 0.8
Worry too long after embarrassment 0.6 1.0 3.6 -0.3 0.1 0.0 -1.0 -0.8 -1.9 -1.2 0.4 -0.4 -1.6 -0.5 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 3.4 4.4 11.5 -2.4 -3.4 -3.1 0.3 -1.3 0.9 -1.3 -2.2 -1.8 -2.0 -2.9 0.8
Wheeze or whistling in the chest in last year 1.7 3.1 8.1 2.5 -1.0 -0.7 0.3 2.8 0.9 2.1 1.5 2.5 1.6 -0.4 2.0
Number of children fathered 2.5 2.8 6.4 1.4 -1.3 -1.7 0.6 2.2 1.7 2.5 0.6 2.2 2.1 0.2 1.8
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 4.5 -0.8 -1.9 -2.1 0.1 -0.5 1.1 0.0 -1.1 0.0 -0.3 -0.6 0.6
Age at first live birth 0.4 0.7 1.3 -1.2 -0.9 -1.2 0.9 -0.6 0.9 -0.6 -0.8 -0.8 -0.6 -1.0 0.5
Pulse wave peak to peak time 1.0 1.2 2.7 -1.5 -0.5 -0.3 0.5 -1.2 0.5 -1.6 -1.0 -1.5 -1.3 -1.4 0.0
Health satisfaction 0.1 0.2 0.7 -0.4 -0.1 -0.1 -0.1 -0.7 -0.1 -0.8 -0.4 -0.4 -0.3 -0.4 -0.5
Shortness of breath walking on level ground 0.6 0.8 4.4 -0.7 -1.1 -1.0 -0.2 -0.1 0.5 -1.0 -2.1 -0.5 -0.8 0.1 0.1
Qualifications: College or University degree 0.5 1.5 4.9 -0.1 2.2 2.2 -0.2 -0.9 -1.4 -0.5 1.9 -0.7 -0.1 0.2 -1.2
Eye problems/disorders: None of the above 0.6 0.7 1.3 1.1 0.2 0.1 0.8 0.8 0.6 0.7 0.6 1.1 0.9 1.2 0.8
Mouth/teeth dental problems: Loose teeth 0.4 0.4 2.1 -0.1 -0.0 -0.2 1.4 -0.2 0.6 -0.4 0.5 -0.2 -0.6 1.1 0.8
Emphysema/chronic bronchitis 0.8 0.9 4.4 -0.2 -2.1 -2.1 -0.3 0.2 0.3 0.1 -0.5 0.4 -0.8 -0.4 0.6
Medication for pain relief, constipation, heartburn 1.0 1.6 5.1 1.7 1.2 1.2 0.8 1.2 -0.6 1.3 2.2 1.5 1.6 0.5 0.1
Neck or shoulder pain in last month 0.7 1.0 2.9 -0.9 -1.6 -1.4 -1.5 -0.9 0.6 0.0 -1.7 -0.6 -0.2 -0.5 0.3
Medication: Blood pressure 1.0 1.8 5.1 -0.8 -2.2 -2.3 1.3 0.1 2.1 -0.3 -1.6 -0.3 -0.8 -0.7 1.3
Angina (self-reported) 1.4 1.9 5.6 1.7 -0.0 -0.2 -0.6 2.3 0.1 2.4 1.0 1.9 1.7 0.1 0.7
Migraine (self-reported) 0.5 0.6 1.9 -1.0 -0.8 -0.6 -0.2 -0.7 0.3 -0.9 -1.4 -0.7 -0.8 -0.9 0.1
Medication: Ibuprofen 0.7 0.9 3.5 -0.8 -0.4 0.0 -1.9 -0.6 -0.8 -0.6 -1.6 -0.8 -1.0 0.3 -0.6
Medication: Allopurinol 0.5 0.7 1.9 -0.3 1.4 1.3 0.0 -0.6 -0.8 -0.9 0.1 -0.8 -0.6 0.6 -1.1
Medication: Omeprazole 0.5 0.6 2.0 0.1 -1.1 -1.4 0.7 0.2 0.4 0.7 0.8 0.5 1.0 -1.1 0.2
Medication: Seretide 50 evohaler 0.5 0.6 2.0 -0.1 -1.4 -1.2 -0.9 0.9 -0.1 0.1 -0.9 0.2 -0.8 -0.5 0.7
Mean time to correctly identify matches 0.1 0.2 0.9 -0.2 -0.1 -0.1 -0.9 -0.3 -0.4 -0.1 -0.0 -0.2 -0.7 -0.1 -0.1
Heart disease (mother) 0.5 0.5 3.6 -0.4 -0.3 -0.0 -1.2 0.1 0.7 0.6 -1.9 -0.3 -0.0 0.3 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 2.4 0.1 0.5 0.5 -1.6 -0.1 -0.9 0.2 -0.2 0.1 0.1 0.1 -0.7
Whole body fat mass 0.9 3.8 10.7 -0.1 -3.0 -3.3 0.4 0.7 3.1 1.0 -2.2 0.7 -0.3 0.2 3.1
Leg fat mass (right) 1.5 5.9 15.8 0.1 -3.8 -4.0 0.5 1.3 3.7 1.8 -2.5 1.1 0.4 -0.3 3.8
Arm predicted mass (right) 2.9 15.1 39.8 1.9 -5.5 -6.3 2.9 2.9 5.5 3.6 -1.5 3.3 1.7 0.2 5.6
Pulse rate, automated reading 0.1 0.2 0.6 0.5 -0.5 -0.7 0.3 0.5 -0.6 0.6 0.1 0.8 0.0 0.6 0.2
Alcohol intake frequency. 0.3 0.6 1.3 0.5 -1.0 -1.1 1.0 0.4 1.0 0.1 0.2 0.6 1.0 -0.0 1.0
Comparative height size at age 10 1.4 7.5 13.2 3.1 -1.5 -2.7 3.4 2.5 2.9 3.0 2.7 3.6 1.3 1.9 3.3
Number of full sisters 1.0 1.3 3.3 -1.5 -1.1 -0.6 -0.6 -1.3 0.3 -0.9 -1.5 -1.4 -0.9 -1.8 0.4
Suffer from ‘nerves’ 1.1 1.8 5.0 -1.2 -2.2 -2.0 0.1 -0.7 0.7 -1.3 -2.0 -0.7 -1.7 -0.7 0.4
Overall health rating 0.8 1.7 7.3 0.0 -2.7 -2.1 -0.3 0.1 0.5 -0.1 -0.4 0.4 -0.3 -2.2 1.6
Chest pain or discomfort 1.2 1.7 6.3 0.2 -2.5 -2.0 -0.4 0.4 0.8 0.2 -1.0 0.5 -0.1 -2.2 1.7
Had major operations 0.7 0.9 4.4 -1.1 -0.6 -0.0 1.1 -0.5 0.3 -0.7 -0.6 -1.3 -0.6 -2.1 0.3
Age at last live birth 0.2 0.3 0.8 -0.8 -0.0 -0.5 0.8 -0.9 0.8 -0.4 0.1 -0.7 -0.2 0.6 -0.1
Family relationship satisfaction 1.4 1.8 4.7 -1.2 0.1 0.3 -0.9 -1.4 -1.4 -1.8 -1.4 -1.2 -2.2 -1.2 -1.4
Leg pain on walking 0.3 0.4 1.2 -0.3 -0.1 -0.3 -0.5 -0.8 -0.3 -1.1 0.0 -0.2 -1.1 0.0 -1.0
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 4.7 -0.4 1.7 2.2 -2.2 -0.8 -1.2 -0.3 -0.8 -0.6 0.2 0.4 -0.9
Commuting to job workplace: Car/motor vehicle 1.9 2.2 6.6 0.3 -2.4 -2.6 1.1 1.4 1.8 1.3 -0.4 0.9 0.4 -0.5 2.1
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.8 -0.4 -0.1 -0.0 -0.2 -0.1 0.5 -0.2 -0.9 -0.5 -0.7 -0.7 0.3
Medication: Aspirin 1.0 1.3 4.9 0.0 -1.2 -1.4 0.4 0.9 2.2 1.1 -1.4 0.5 1.0 0.1 1.5
Supplements: Vitamin C 1.6 1.9 5.8 -0.1 2.0 2.4 -0.9 -1.2 -2.0 -0.8 1.3 -0.8 -0.8 0.9 -1.2
Knee pain experienced in last month 1.3 2.0 6.5 -0.6 1.0 1.7 -2.5 -0.5 -2.3 -1.0 -0.5 -1.1 -1.8 -0.4 -1.3
Hypertension (Self-reported) 0.4 1.1 5.7 -1.1 -1.0 -0.9 -0.9 -0.1 1.3 -0.1 -2.4 -0.8 -0.4 -0.8 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.9 -0.1 -0.7 -0.5 0.3 -0.2 -0.2 0.2 0.5 -0.0 0.1 -1.4 0.1
Illnesses of father: Heart disease 0.9 1.2 4.9 -0.6 1.1 1.2 -2.2 -0.7 -1.5 -0.2 -0.3 -0.8 0.2 0.2 -1.8
Illnesses of siblings: Diabetes 1.0 1.2 2.8 0.7 -0.8 -1.0 0.8 1.2 1.7 1.0 -1.4 0.8 1.4 0.2 1.3
Smoking status: Previous 0.2 0.4 1.9 0.4 -0.6 -0.2 -1.4 0.5 0.1 0.5 -0.6 0.2 -0.5 0.3 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.5 0.5 -0.7 -1.2 -0.2 0.3 0.7 0.4 -0.1 0.8 -0.1 1.1 0.2
Whole body fat-free mass 2.8 16.0 39.4 2.4 -5.3 -6.3 3.4 3.2 5.6 3.9 -0.4 3.8 1.9 0.4 5.7
Leg fat-free mass (right) 2.3 12.3 37.7 1.5 -5.3 -6.1 3.3 1.9 4.9 2.6 -0.6 2.7 0.7 -0.3 5.1
Arm fat percentage (left) 0.4 1.8 4.3 -1.1 -1.9 -1.9 -0.3 -0.5 1.7 -0.4 -2.1 -0.6 -1.4 -0.4 1.7
Average weekly red wine intake 0.5 0.8 2.7 -0.0 -1.4 -1.3 0.9 0.2 1.5 0.5 -0.1 0.2 -0.1 0.0 1.6
Handedness (chirality/laterality): Left-handed 0.5 0.6 3.0 -0.3 -0.2 0.2 0.3 -0.6 -0.6 -1.4 0.4 -0.5 -1.7 -0.8 -0.1
Mood swings 2.2 4.0 8.6 -1.9 -2.9 -2.6 1.1 -1.4 2.1 -2.0 -2.6 -1.4 -2.2 -1.3 1.5
Loneliness, isolation 0.4 0.6 1.8 -0.6 -1.1 -1.0 0.2 -0.5 0.4 -0.9 -0.6 -0.5 -1.3 0.2 0.6
Long-standing illness, disability or infirmity 0.7 1.0 4.6 -0.7 -1.4 -1.2 -1.1 -0.6 -0.3 -0.4 -1.2 -0.4 -0.7 -2.1 -0.2
Ever had bowel cancer screening 1.1 1.3 4.6 -1.2 -0.7 -0.2 -0.1 -1.4 0.5 -1.5 -2.1 -1.5 -1.1 -0.7 0.1
Diabetes diagnosed by doctor 0.8 1.3 6.3 -0.7 -1.6 -1.5 -0.6 0.2 1.4 0.4 -2.5 -0.3 -0.1 -0.9 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 2.7 -1.0 -1.4 -1.6 0.0 -0.9 1.1 -0.8 -1.2 -0.6 -1.2 -0.3 0.5
Friendships satisfaction 2.0 2.5 5.9 -2.1 -0.6 -0.6 -0.8 -1.9 -0.5 -2.0 -2.4 -1.8 -2.2 -1.1 -1.0
Qualifications: nursing, teaching 0.2 0.3 0.8 -0.6 -0.6 -0.9 0.2 -0.4 0.4 -0.2 -0.2 -0.3 -0.5 -0.9 -0.1
Commuting to job workplace: Walk 0.6 0.7 1.9 0.3 1.2 1.3 1.4 -0.1 -0.1 -0.2 1.1 -0.1 1.0 -0.9 -0.1
Eye problems/disorders: Cataract 0.3 0.3 0.8 -0.6 -0.8 -0.7 -0.1 -0.3 -0.3 -0.5 -0.5 -0.6 -0.5 -0.9 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 2.3 -0.4 -1.5 -1.5 0.5 0.1 1.4 -0.1 -1.1 -0.4 -0.4 -1.1 0.9
Medication for cholesterol 0.2 0.3 0.8 -0.2 0.4 0.3 0.7 -0.4 -0.4 -0.8 0.6 -0.3 -0.9 0.2 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 3.2 -0.3 1.2 0.9 1.8 -1.0 -0.3 -0.8 1.7 -0.7 -0.1 -0.2 -0.6
Back pain experienced in last month 0.2 0.2 0.7 -0.5 -0.1 -0.2 0.5 -0.3 0.1 -0.6 0.6 -0.5 -0.8 0.7 -0.3
Mineral and other dietary supplements 0.1 0.1 0.6 -0.2 0.4 0.1 -0.8 -0.5 -0.0 -0.1 -0.5 -0.1 0.0 -0.1 -0.6
Breast cancer (self-reported) 1.1 1.3 3.0 -1.7 -1.2 -0.6 0.7 -0.4 0.9 -0.6 -1.4 -1.7 -0.4 -1.6 0.9
Asthma (self-reported) 1.2 2.4 7.7 2.2 -0.0 0.1 -1.1 2.8 0.2 2.0 1.3 2.3 1.3 1.2 1.2
Osteoporosis (self-reported) 0.3 0.4 3.0 0.2 0.3 0.4 0.1 0.6 -1.0 0.3 1.7 0.1 -0.1 -0.4 -0.1
Osteoarthritis (self-reported) 0.4 0.6 3.7 -0.8 -0.9 -0.5 -0.3 -0.1 -0.2 -0.1 -0.7 -0.7 -0.5 -1.9 0.1
Medication: Aspirin 0.9 1.2 4.0 0.1 -1.3 -1.5 0.1 1.0 2.0 1.1 -1.3 0.7 0.8 -0.1 1.2
Medication: Gliclazide 2.2 2.4 5.6 -2.3 -0.3 -0.2 0.1 -1.9 0.5 -2.1 -2.2 -2.4 -1.8 -1.3 -0.2
Illnesses of father: None of the above (group 1) 0.7 0.9 4.0 0.7 -0.4 -0.8 2.0 0.3 1.1 0.4 1.4 0.9 0.7 -0.3 0.9
Smoking status: Current 0.8 1.2 2.6 -1.6 -0.6 -0.1 0.5 -1.5 -0.1 -1.5 -0.3 -1.5 -1.6 -1.3 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 4.8 -2.2 -0.0 -0.1 0.1 -2.1 -0.6 -2.1 -0.9 -2.2 -1.8 -1.2 -1.5
Whole body water mass 2.8 16.0 39.2 2.5 -5.2 -6.3 3.5 3.2 5.6 3.9 -0.4 3.8 1.8 0.4 5.7
Leg predicted mass (right) 2.3 12.2 37.0 1.5 -5.2 -6.1 3.3 1.9 4.9 2.6 -0.5 2.8 0.8 -0.3 5.1
Arm fat mass (left) 1.0 4.0 12.1 -0.2 -3.2 -3.5 0.6 0.6 3.0 0.8 -2.0 0.7 -0.7 -0.2 3.1
Number of self-reported non-cancer illnesses 1.1 1.8 5.5 -1.7 -0.9 -0.4 -1.7 -1.1 -0.4 -1.1 -1.5 -1.5 -1.5 -2.4 -0.6
Average weekly champagne plus white wine intake 0.9 1.2 2.3 0.8 -1.0 -1.4 1.0 1.1 1.3 1.5 0.8 1.0 1.4 0.3 1.0
Miserableness 0.4 0.7 1.6 -0.2 -0.9 -1.2 0.8 -0.5 1.2 -1.3 -0.5 -0.1 -0.9 0.6 0.5
Guilty feelings 1.0 1.4 4.1 -1.6 -0.5 -0.1 0.4 -1.5 -0.2 -2.0 -0.7 -1.7 -1.6 -1.4 -0.1
Wears glasses or contact lenses 1.6 1.8 3.8 1.4 1.6 1.2 -0.4 0.8 -1.5 1.2 1.9 1.2 0.9 2.0 -1.3
Ever taken oral contraceptive pill 2.0 2.2 6.4 -1.3 -2.4 -1.8 -0.1 -0.2 1.4 -0.8 -1.4 -0.8 -1.2 -2.5 1.5
Hearing aid user 1.4 1.6 3.5 1.5 1.1 0.8 -0.3 1.3 0.4 1.8 1.4 1.5 1.9 1.5 0.5
Mother’s age at death 1.0 1.3 2.6 1.1 1.6 1.1 -0.8 0.9 -1.2 1.0 1.3 0.9 0.6 0.9 -1.6
Financial situation satisfaction 0.9 1.1 3.0 -1.2 -0.4 -0.3 0.4 -1.4 0.1 -1.7 -1.1 -1.3 -1.4 -0.9 -0.4
Tinnitus: Yes, now most or all of the time 1.4 1.6 3.8 1.7 0.8 0.6 -0.7 1.1 -0.5 1.5 1.8 2.0 1.8 0.9 -0.3
Commuting to job workplace: Public transport 1.9 2.3 6.3 -0.3 2.4 2.5 -1.9 -0.8 -1.9 -1.1 -0.2 -0.9 -0.6 0.3 -2.1
Eye problems/disorders: Glaucoma 0.1 0.2 0.9 -0.2 -0.2 -0.2 0.3 0.0 0.3 0.6 0.4 -0.0 0.3 -0.9 0.4
Medication: Blood pressure 0.5 0.9 3.7 -0.2 -0.1 0.0 -1.8 0.6 0.9 1.0 -1.9 -0.2 1.2 -0.0 0.2
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.6 -0.5 0.0 0.3 -0.0 -0.1 0.2 -0.3 -0.7 -0.8 -0.3 -0.0 0.0
Supplements: Fish oil (including cod liver oil) 0.4 0.5 2.1 -0.1 0.8 0.6 -0.8 -0.2 -1.2 -0.4 0.1 -0.3 -0.5 0.8 -1.4
High cholesterol (Self-reported) 0.8 1.5 8.5 -0.9 -0.8 -0.7 -2.5 0.0 0.3 0.3 -2.9 -0.6 -0.5 -0.2 -0.3
Medication: Bendroflumethiazide 0.3 0.5 1.4 -0.5 -1.2 -1.0 0.1 -0.2 0.9 -0.0 -0.8 -0.5 -0.0 -1.0 0.7
Medication: Paracetamol 1.7 2.6 5.2 -2.0 -0.2 -0.1 -1.5 -1.5 -0.9 -2.0 -2.3 -2.0 -2.2 -0.5 -1.8
Medication: Lisinopril 0.1 0.2 0.7 -0.2 0.1 -0.4 0.5 -0.0 0.8 -0.1 -0.6 -0.1 0.4 0.6 -0.2
Medication: Atorvastatin 0.4 0.4 1.5 -0.5 -1.0 -0.8 -0.8 0.3 0.3 0.4 -0.8 -0.2 0.2 -1.2 0.4
Illnesses of father: High blood pressure 0.2 0.2 0.6 -0.4 -0.7 -0.7 -0.1 0.1 0.7 0.1 -0.6 -0.1 -0.2 0.8 0.4
Alcohol drinker status: Never 0.6 0.7 4.0 0.8 -0.4 -0.5 2.0 0.9 0.7 0.2 1.1 0.7 0.3 0.0 0.9
Ever smoked 1.1 2.0 5.9 -1.3 -0.9 -0.1 -1.8 -1.2 -0.9 -1.6 -1.3 -1.5 -2.4 -1.8 0.4
Basal metabolic rate 2.6 14.3 36.7 2.2 -5.2 -6.1 3.0 2.9 5.3 3.6 -0.6 3.5 1.5 0.4 5.5
Leg fat percentage (left) 0.9 3.1 9.5 -0.7 -2.7 -2.5 -1.1 0.6 2.4 0.9 -3.1 -0.1 0.0 -0.3 2.5
Arm fat-free mass (left) 3.1 15.7 37.3 2.4 -5.1 -6.1 2.6 3.4 5.5 4.2 -1.1 3.8 2.0 0.9 5.6
Number of operations (self-reported) 2.5 3.7 10.0 0.5 -2.7 -2.1 2.9 0.6 2.2 0.8 0.1 0.8 1.0 -2.5 3.2
Average weekly beer plus cider intake 0.5 0.8 1.7 -0.6 0.4 0.5 -1.2 -1.0 -1.3 -1.2 -0.2 -0.5 -1.2 -0.1 -1.1
Irritability 0.5 0.8 1.9 -0.9 -1.3 -1.4 -0.0 -0.5 0.6 -0.7 -1.2 -0.5 -0.9 -1.3 0.2
Risk taking 3.1 4.5 8.3 -2.9 -2.5 -1.7 -0.1 -2.2 0.9 -2.2 -2.5 -2.6 -2.5 -2.2 1.2
Ever had prostate specific antigen (PSA) test 1.8 2.1 7.2 1.2 2.7 2.4 0.1 0.1 -1.0 0.5 1.7 0.6 0.7 2.0 -1.4
Fractured/broken bones in last 5 years 1.0 1.2 5.2 1.5 0.8 1.0 -0.9 0.3 -1.6 0.9 2.3 1.0 0.7 -0.4 -0.3
Age started oral contraceptive pill 0.5 0.6 1.3 0.3 -1.2 -1.0 -0.2 1.1 1.0 0.9 -0.4 0.5 0.5 -0.7 0.9
Diastolic blood pressure, automated reading 0.4 1.2 3.8 -1.6 -0.6 -0.4 -0.3 -0.9 -0.8 -1.1 -1.9 -1.4 -1.4 -0.2 -1.1
Ever depressed for a whole week 0.6 0.7 2.9 -1.1 -0.2 -0.5 -1.0 -0.8 -0.5 -1.0 -0.1 -0.8 -1.7 0.6 -0.6
Unable to work because of sickness or disability 0.8 1.1 2.9 -1.0 -1.5 -1.3 0.8 -1.1 -0.1 -1.2 -0.2 -0.7 -1.3 -1.7 0.3
Commuting to job workplace: Cycle 1.2 1.5 5.2 0.8 2.3 2.0 -0.9 0.1 -0.9 0.3 1.4 -0.0 0.0 1.4 -1.5
Myopia 0.6 0.9 2.4 1.4 -0.0 -0.3 1.5 0.9 -0.2 0.8 1.5 1.4 0.2 0.2 0.2
Vascular/heart problems diagnosed by doctor 0.6 1.5 6.3 1.4 1.6 1.2 0.9 0.4 -1.1 0.3 2.5 1.1 0.8 1.5 -0.4
Cholesterol lowering medication 1.3 1.9 7.4 -1.4 -2.0 -1.4 -1.7 -0.9 0.6 -0.2 -2.7 -1.1 -0.4 -1.4 0.4
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.3 0.3 -0.7 -1.0 0.2 0.1 0.1 0.8 0.8 0.6 1.1 -0.4 0.0
Pain experienced in last month 0.1 0.2 0.5 0.1 0.7 0.7 0.3 -0.2 -0.2 0.1 0.7 0.0 0.4 -0.1 -0.3
Supplements: Calcium 0.8 0.9 3.6 0.2 1.0 0.9 -0.1 -0.5 -1.7 -0.7 1.9 0.0 -0.6 0.4 -0.8
Basal cell carcinoma (self-reported) 1.8 2.2 5.7 -0.7 -2.2 -2.4 1.9 -0.5 2.2 0.0 -1.5 -0.2 0.4 -1.0 1.9
Heart attack/myocardial infarction (self-reported) 0.3 0.3 1.0 -0.4 -0.8 -1.0 -0.2 -0.1 1.0 -0.1 -1.0 -0.1 -0.1 0.4 -0.1
Deep venous thrombosis (DVT) (self-reported) 4.3 5.5 15.6 0.8 -3.0 -3.2 3.0 1.2 4.0 1.4 -0.4 1.4 1.6 -0.6 3.6
Heart disease (siblings) 0.1 0.1 0.6 -0.3 -0.2 -0.2 -0.7 -0.3 0.2 -0.2 -0.7 -0.1 -0.3 -0.4 -0.4
Alcohol drinker status: Previous 0.9 1.1 3.4 -0.3 -1.2 -1.4 0.7 0.4 1.8 0.2 -1.6 -0.1 0.7 -0.9 1.2
Pack years of smoking 0.1 0.1 0.4 -0.6 -0.4 -0.1 0.1 -0.3 0.4 -0.4 -0.0 -0.2 -0.1 -0.6 0.5
Impedance of whole body 2.3 11.8 33.3 -0.8 5.6 5.8 -2.4 -2.2 -4.6 -2.5 2.5 -2.0 -1.2 2.0 -4.7
Leg fat mass (left) 1.6 6.3 17.4 0.1 -4.0 -4.2 0.5 1.3 3.8 1.7 -2.6 1.1 0.3 -0.3 3.9
Arm predicted mass (left) 3.0 15.5 34.1 2.6 -4.9 -5.8 2.7 3.5 5.5 4.2 -0.9 3.9 2.2 0.9 5.5