Best TWAS P=6.82e-17 · Best GWAS P=2.27e-16 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PHC2 | 0.12 | 0.09 | bslmm | 500 | 0.12 | 4.7e-14 | -4.8 | -5.9 | 3.4e-09 | -0.58 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | TMEM54 | 0.05 | 0.00 | blup | 281 | 0.02 | 4.5e-03 | -3.8 | 8.3 | 6.8e-17 | 0.50 | 0.12 | 0.20 | TRUE |
3 | CommonMind | Brain Pre-frontal Cortex | ZNF362 | 0.05 | 0.06 | lasso | 1 | 0.06 | 2.2e-07 | 7.8 | 7.8 | 9.2e-15 | 0.98 | 0.01 | 0.99 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | PHC2 | 0.58 | 0.34 | lasso | 7 | 0.28 | 7.3e-10 | 8.1 | -7.9 | 3.2e-15 | -0.99 | 0.01 | 0.99 | TRUE |
5 | GTEx | Heart Atrial Appendage | RN7SKP16 | 0.08 | 0.06 | enet | 11 | 0.03 | 1.9e-02 | -4.6 | 6.0 | 1.8e-09 | 0.56 | 0.15 | 0.46 | FALSE |
6 | GTEx | Muscle Skeletal | ZNF362 | 0.04 | 0.01 | enet | 7 | 0.02 | 4.9e-03 | -4.6 | 5.9 | 3.2e-09 | 0.68 | 0.06 | 0.81 | FALSE |
7 | METSIM | Adipose | ZNF362 | 0.09 | 0.02 | enet | 32 | 0.03 | 1.5e-05 | 7.8 | 5.6 | 2.7e-08 | 0.70 | 0.01 | 0.98 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | PHC2 | 0.11 | 0.07 | lasso | 3 | 0.05 | 2.2e-07 | 8.1 | 7.8 | 8.4e-15 | 0.99 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | S100PBP | 0.03 | 0.02 | blup | 46 | 0.02 | 6.6e-06 | 5.0 | -5.3 | 1.4e-07 | -0.07 | 0.01 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZNF362 | 0.03 | 0.01 | blup | 49 | 0.01 | 1.3e-03 | -3.1 | 6.5 | 1.1e-10 | 0.72 | 0.01 | 0.32 | FALSE |
11 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | S100PBP | 0.06 | 0.03 | blup | 48 | 0.06 | 6.8e-04 | 4.6 | -5.7 | 1.3e-08 | -0.06 | 0.01 | 0.73 | FALSE |