Hub : Genes

RQCD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.12600	0.0640	8.8e-03	0.036	NA	-0.002	NA	0.007	4.2e-02	NA	3.6e-01	NA	2.1e-01
2	GTEx	Breast Mammary Tissue	0.19200	0.0790	9.0e-03	0.015	NA	0.010	NA	0.025	5.6e-02	NA	9.1e-02	NA	1.8e-02
3	GTEx	Breast Mammary Tissue (Male)	0.44929	0.1165	3.9e-03	0.045	NA	0.099	NA	0.100	3.3e-02	NA	2.7e-03	NA	2.6e-03
4	GTEx	Breast Mammary Tissue (Female)	0.00727	0.0401	4.4e-01	0.004	NA	-0.010	NA	-0.009	2.5e-01	NA	8.5e-01	NA	7.8e-01
5	GTEx	Heart Left Ventricle	0.06027	0.0303	2.3e-03	0.045	NA	0.011	NA	0.031	1.9e-03	NA	7.9e-02	NA	9.0e-03
6	GTEx	Whole Blood	0.04500	0.0230	4.9e-03	0.015	NA	-0.002	NA	0.001	1.4e-02	NA	5.3e-01	NA	2.4e-01
7	NTR	Blood	0.01910	0.0067	1.0e-09	0.035	0.027	0.034	0.027	0.035	1.6e-11	4.2e-09	4.1e-11	4.4e-09	1.9e-11
8	ROSMAP	Brain Pre-frontal Cortex	0.04440	0.0169	1.2e-07	0.064	0.054	0.069	0.057	0.068	1.1e-08	1.6e-07	3.1e-09	7.1e-08	4.3e-09
9	YFS	Blood	0.03240	0.0097	0.0e+00	0.071	0.057	0.056	0.056	0.066	2.8e-22	5.5e-18	7.1e-18	7.0e-18	9.5e-21
10	TCGA	Uterine Corpus Endometrial Carcinoma	0.15700	0.1280	2.6e-03	0.063	0.031	0.057	NA	0.043	7.6e-03	4.7e-02	1.1e-02	NA	2.4e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.3	0.4	1.0	0.5	-0.5	-1.0	0.8	0.5	-0.4	-0.6	0.7	-0.7	0.3
Bipolar Disorder or Schizophrenia	0.4	1.1	2.5	1.6	1.2	0.4	0.2	1.0	-0.9	-1.1	1.4	-1.0	0.8
Depressed Affect (Nagel 2018)	0.5	1.0	4.2	1.7	2.0	-0.1	0.1	0.9	-0.6	-0.9	0.8	-0.8	0.1
Depression (Nagel 2018)	0.5	0.8	1.7	1.3	1.0	-0.5	0.7	1.1	-0.6	-0.9	1.0	-0.8	-0.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.6	-0.9	1.2	-1.6	0.2	-1.0	0.8	0.7	-1.2	0.7	-0.2
Neuroticism (Nagel 2018)	0.3	0.7	1.7	-0.1	1.3	-1.0	0.8	-0.7	1.0	0.6	-0.7	0.7	-1.0
Schizophrenia (2018)	0.6	1.3	4.1	1.6	2.0	1.3	-0.4	0.9	-0.8	-0.9	1.0	-0.7	0.8
Schizophrenia vs Biploar Disorder	0.4	0.5	2.0	-0.5	0.3	1.4	-0.2	-0.6	0.7	0.9	-0.5	0.9	-0.3
Worry (Nagel 2018)	0.5	1.2	2.8	-0.9	0.6	-1.5	1.7	-1.0	1.1	0.9	-0.9	0.9	-0.9
Alzheimer’s Disease (in mother)	1.9	2.2	3.9	-2.0	-0.8	-1.3	1.5	-1.5	1.4	1.7	-1.4	1.6	-1.4
Alzheimer’s Disease (in father)	1.2	1.3	2.7	0.7	-1.4	-0.9	-0.3	1.2	-1.6	-1.1	1.1	-1.3	1.3
Alzheimer’s Disease (including proxy)	0.4	0.6	3.3	-0.7	-1.0	-1.0	1.8	-0.2	-0.1	0.4	-0.2	0.2	-0.2
Crohns Disease (2017)	1.1	2.4	6.0	1.8	-0.9	1.7	-2.5	1.6	-0.7	-1.6	1.7	-1.3	0.7
Irritable Bowel Disease (IBD)	1.1	2.7	20.8	0.6	-1.9	0.7	-4.6	0.7	-0.3	-0.5	0.6	-0.4	-0.6
Ulcerative Colitis (UC)	1.1	2.1	15.4	-0.5	-1.3	-0.1	-3.9	-0.5	0.2	0.7	-0.8	0.6	-1.3
Major Depression (MDD)	2.3	2.9	5.0	2.0	-0.0	-0.1	1.5	1.9	-2.1	-1.9	2.2	-2.0	1.2
Reaction Time	0.7	1.3	5.3	1.5	1.8	2.3	-0.4	0.8	-0.3	-0.5	0.5	-0.5	0.8
Verbal and Numeric Reasoning (VNR)	0.7	1.7	2.8	-1.5	0.6	-1.4	1.4	-1.5	1.4	1.2	-1.7	1.2	-1.0
Breast Cancer	0.5	1.1	4.9	-0.9	-1.5	0.5	-2.2	-0.5	0.4	0.7	-0.5	0.7	-1.0
Ovarian Cancer	1.7	2.3	3.7	1.9	0.5	-0.3	-1.3	1.7	-1.7	-1.8	1.8	-1.8	1.3
Prostate Cancer	0.4	0.6	1.5	0.6	1.2	0.6	0.4	0.5	-0.5	-1.0	0.3	-1.0	0.9
Age at First Birth	1.9	2.7	4.5	2.0	0.6	-0.5	0.0	2.0	-2.0	-2.1	1.7	-2.1	1.6
Bipolar Disorder (2011)	0.6	0.5	2.2	0.7	1.5	1.5	0.2	-0.0	0.6	0.1	-0.1	0.2	-0.3
Body Mass Index (BMI) (2010)	5.6	7.7	15.5	3.9	1.6	2.8	-1.5	3.0	-3.3	-2.9	3.2	-2.9	1.1
Coronary Artery Disease (CAD)	0.2	0.2	1.9	0.1	-0.3	1.4	-0.2	0.2	0.1	-0.2	0.0	-0.2	-0.1
Crohns Disease (2012)	0.1	0.2	1.2	0.5	-0.1	0.6	-1.1	-0.0	0.3	-0.1	-0.1	0.2	0.1
Mean Putamen Volume	0.4	0.4	1.9	-0.8	-1.4	-1.1	-0.3	-0.3	0.3	0.2	-0.2	0.3	-0.5
Fasting Glucose	0.8	0.9	3.0	1.0	1.2	1.3	-1.7	0.6	-0.6	-0.4	0.6	-0.5	0.9
HbA1C	0.5	0.6	1.2	0.8	-1.0	-0.3	-1.1	0.4	-0.8	-0.7	0.6	-0.6	1.0
HDL Cholesterol	1.0	1.7	3.2	1.1	-0.5	-1.0	0.3	1.6	-1.8	-1.4	1.6	-1.6	1.2
LDL Cholesterol	0.8	1.2	4.3	-0.9	0.3	0.9	-2.1	-1.0	0.7	1.2	-1.2	1.1	-0.9
Lupus	0.4	0.6	4.1	-0.2	-0.8	-2.0	0.4	0.2	-0.2	-0.6	0.2	-0.5	0.8
Neuroticism (2016)	0.6	0.9	1.8	-0.5	1.3	0.5	1.0	-0.9	1.3	0.7	-0.9	1.0	-0.9
Primary Biliary Cirrhosis	2.1	3.0	5.4	-1.7	-0.0	-1.1	-1.5	-2.0	2.3	1.8	-2.0	1.9	-1.7
Rheumatoid Arthritis	0.8	1.0	4.2	1.1	2.0	0.7	-0.4	0.6	-0.6	-0.6	0.3	-0.8	1.6
Schizophrenia (2014)	0.3	0.8	1.3	1.1	1.1	0.5	0.1	1.0	-0.7	-1.0	1.1	-0.8	0.8
Triglycerides	3.4	5.5	10.3	-2.2	1.3	1.1	-0.5	-2.9	2.9	2.7	-3.2	2.9	-2.1
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.9	-0.6	-0.4	0.6	0.1	-0.9	0.7	0.7	-0.6	0.9	-0.1
Ulcerative Colitis	1.7	2.4	18.7	-0.4	-1.5	0.0	-4.3	-0.4	0.3	0.8	-0.8	0.6	-1.1
Blood Eosinophil Count	0.7	5.5	8.4	-2.9	-0.9	-2.0	1.8	-2.9	2.5	2.8	-2.8	2.7	-1.5
Blood Platelet Count	6.1	70.4	118.8	8.3	-4.3	4.4	-10.9	9.7	-8.8	-8.8	10.4	-8.6	6.9
Blood Red Count	10.9	104.9	165.1	-12.7	-1.1	-5.3	3.8	-12.6	12.8	11.8	-12.7	12.0	-8.7
Blood White Count	0.5	3.5	15.5	-1.4	-0.4	-2.9	3.9	0.1	-0.1	-0.3	-0.8	-0.3	2.8
Heel T-Score	0.3	2.4	11.9	1.9	1.8	2.0	-3.5	0.5	0.1	-0.5	0.5	-0.3	1.0
BMI	4.5	26.4	45.4	6.7	3.2	4.1	-0.1	5.8	-6.0	-5.8	5.7	-5.9	4.5
Height	12.0	232.0	428.5	-20.7	-7.7	-16.5	10.0	-16.6	15.7	15.3	-18.2	15.2	-11.9
Waist Hip Ratio (WHR)	1.9	8.4	22.7	-4.1	-4.8	-2.0	-3.8	-2.2	2.4	2.1	-2.3	2.1	1.1
Systolic Blood Pressure	0.4	1.9	9.5	1.3	0.4	1.4	-3.1	0.9	-0.9	-1.0	0.6	-1.0	1.4
Smoking Status	0.2	0.4	1.5	0.8	1.2	0.6	0.4	0.4	-0.4	-0.5	0.6	-0.5	0.7
Allergy or Eczema	2.9	7.7	10.9	2.9	-2.1	-0.9	-2.4	3.2	-3.3	-3.3	3.3	-3.3	2.1
Cardiovascular Disease	1.2	4.0	10.1	2.1	0.8	0.8	-2.2	2.1	-1.9	-2.3	1.5	-2.2	3.2
Hypothyroidism (self reported)	2.6	5.9	9.6	2.4	-0.6	0.6	-0.9	3.0	-3.0	-3.1	3.1	-3.0	2.4
Respiratory disease	0.7	1.5	4.4	1.3	-0.6	-0.3	-2.1	1.2	-1.3	-1.0	1.5	-1.1	1.0
Type 2 Diabetes (T2D) (2018)	0.7	1.4	8.9	-0.9	-3.0	-1.6	-1.1	0.1	0.0	0.0	-0.0	0.0	0.3
Lung FEV1/FVC ratio	0.3	1.7	2.5	1.6	1.4	1.2	-1.1	1.2	-1.2	-1.5	0.8	-1.5	1.3
Lung FVC	1.1	5.7	9.0	3.0	0.9	1.0	2.0	2.7	-3.0	-2.5	2.5	-2.7	2.4
Neuroticism	0.8	2.0	4.5	-0.7	1.8	-1.3	2.1	-1.3	1.5	1.2	-1.2	1.3	-1.1
Chronotype (morning person)	2.5	5.7	9.7	-2.2	1.3	1.0	-0.1	-3.1	3.1	2.8	-2.9	2.8	-2.5
Hair Pigment	0.0	0.9	4.7	-0.3	-1.4	0.7	2.2	0.3	-0.5	-0.2	0.4	-0.2	1.3
Tanning	0.6	7.2	15.0	3.9	2.3	1.5	1.1	3.0	-2.9	-2.8	3.0	-2.9	2.3
Hand grip strength (left)	2.5	6.5	21.3	-3.4	-2.5	-4.6	1.5	-2.4	2.2	1.9	-2.3	1.9	-0.9
Number of treatments/medications taken	1.7	3.1	5.0	2.1	1.2	1.5	-0.4	1.9	-2.0	-2.0	1.6	-2.0	2.2
Average weekly spirits intake	0.9	1.1	2.1	1.1	-0.3	-1.0	0.1	1.4	-1.3	-1.2	1.2	-1.2	0.5
Sensitivity / hurt feelings	0.3	0.5	0.9	-1.0	-0.2	-0.0	0.6	-0.8	0.9	0.9	-0.7	0.9	-0.1
Frequency of depressed mood in last 2 weeks	0.1	0.1	1.0	0.4	1.0	0.2	0.2	0.1	-0.2	-0.1	-0.1	-0.2	-0.3
Hearing difficulty/problems: Yes	0.4	0.6	1.3	0.5	-0.7	-1.1	1.1	0.8	-0.6	-0.6	0.5	-0.7	0.6
Relative age of first facial hair	1.5	3.0	5.5	1.8	-1.1	0.6	-2.0	2.1	-2.1	-1.8	2.3	-1.9	0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.9	0.8	1.1	0.1	0.6	0.8	-0.7	-0.8	0.3	-0.9	1.4
Ever used hormone-replacement therapy (HRT)	0.7	0.9	4.3	-0.0	1.2	0.4	2.1	-0.7	0.3	0.7	-0.4	0.7	-1.2
Ever had hysterectomy (womb removed)	1.7	1.9	5.0	-1.1	-0.0	-0.3	0.2	-1.7	1.6	1.5	-1.4	1.6	-2.2
Systolic blood pressure, automated reading	1.7	4.9	9.2	3.0	1.1	2.5	-1.4	2.4	-2.7	-2.3	2.3	-2.4	1.3
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.9	0.6	-1.5	-0.1	-2.0	1.3	-1.4	-1.0	1.5	-1.0	1.0
Angina	0.3	0.4	1.9	-0.0	0.2	0.9	-0.6	0.3	-0.3	-0.3	-0.3	-0.4	1.4
Medication for hormone replacement therapy	0.9	1.0	1.7	1.3	1.1	0.6	0.7	0.7	-1.1	-0.9	1.1	-0.9	1.2
Vitamin and mineral supplements	0.2	0.3	1.5	0.1	0.7	-0.9	1.2	-0.3	0.3	0.1	-0.2	0.2	-0.0
Supplements: Zinc	2.4	2.6	6.7	-1.8	-0.7	0.0	-1.1	-1.6	1.7	1.8	-1.4	1.8	-2.6
Medication: Co-codamol	1.7	2.0	2.9	1.2	-1.5	-1.6	-0.2	1.5	-1.7	-1.3	1.6	-1.4	1.5
Medication: Metformin	0.4	0.6	3.0	-0.2	-1.5	0.4	-1.7	-0.0	0.0	0.2	-0.0	0.1	0.3
Diabetes (father)	0.3	0.3	1.9	0.1	-0.8	-0.2	-1.4	0.2	-0.1	-0.0	0.7	-0.1	0.3
Diabetes (mother)	0.3	0.4	1.0	0.4	-0.5	0.1	-0.3	0.9	-0.3	-0.8	0.7	-0.7	1.0
Severe depression (siblings)	0.4	0.4	2.5	-0.7	-1.6	-0.7	-0.5	0.1	0.4	0.1	-0.2	0.2	0.7
Pack years adult smoking proportion	0.3	0.4	1.3	-0.1	1.0	1.1	0.5	-0.5	0.6	0.6	-0.3	0.6	-0.6
Impedance of leg (right)	6.8	32.9	54.2	-6.9	-0.9	-2.2	0.5	-7.1	7.4	7.0	-6.8	7.1	-5.1
Leg fat-free mass (left)	0.2	1.1	5.0	-0.9	-0.7	-2.2	1.9	-0.2	-0.2	-0.2	-0.8	-0.2	-0.7
Trunk fat percentage	0.2	0.6	3.2	-0.1	-1.8	0.1	-0.7	0.5	-1.0	-0.6	0.5	-0.7	-0.6
Hand grip strength (right)	3.1	8.3	20.2	-4.0	-2.5	-4.5	1.6	-2.8	2.7	2.6	-2.9	2.6	-1.4
Townsend deprivation index at recruitment	4.1	5.7	8.6	2.9	1.6	2.7	-0.9	2.7	-2.6	-2.3	2.5	-2.4	2.6
Current tobacco smoking	0.3	0.5	1.2	1.1	0.7	0.2	-0.3	0.8	-0.8	-0.7	0.9	-0.8	0.6
Average weekly fortified wine intake	0.4	0.5	1.8	-0.2	-1.3	-1.3	1.2	0.1	-0.2	-0.0	0.2	-0.1	-0.3
Maternal smoking around birth	0.4	0.5	1.1	-0.1	-0.4	-1.0	-0.8	0.7	-0.6	-0.8	0.5	-0.8	1.1
Fed-up feelings	0.1	0.2	1.0	0.7	1.0	-0.3	0.0	0.4	-0.1	-0.2	0.4	-0.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	4.6	2.1	0.9	0.3	0.1	2.0	-1.6	-1.8	1.6	-1.7	1.3
Relative age voice broke	0.8	1.3	4.7	0.6	-1.6	-0.9	-2.2	0.9	-0.8	-0.9	1.3	-0.8	-0.2
Taking other prescription medications	3.6	5.5	8.0	2.8	0.5	1.2	-1.4	2.7	-2.8	-2.8	2.6	-2.8	2.4
Age when periods started (menarche)	0.0	0.1	0.4	-0.1	-0.6	-0.6	-0.3	-0.2	0.0	-0.0	0.1	0.0	-0.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.9	0.8	0.5	0.2	1.4	0.5	-0.6	-0.7	0.5	-0.7	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.1	-0.5	-0.0	0.8	-0.2	-0.2	0.5	0.3	-0.5	0.4	1.1
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.4	1.5	0.4	1.9	-0.5	1.2	-1.3	-1.3	1.2	-1.3	1.0
Qualifications: CSEs or equivalent	0.4	0.6	2.3	0.3	0.9	1.4	-1.5	-0.1	0.2	0.4	0.2	0.4	-0.2
Serious illness, injury or assault to yourself	1.6	2.0	5.2	1.3	0.2	1.0	-0.4	1.5	-1.7	-1.4	1.4	-1.5	2.3
High blood pressure	3.0	8.4	12.9	3.6	2.0	1.7	0.4	3.3	-3.5	-3.5	2.6	-3.5	3.2
Hayfever, allergic rhinitis or eczema	1.3	2.7	4.0	1.9	-1.3	-0.7	-2.0	1.8	-1.8	-1.8	1.9	-1.8	1.0
Multivitamins +/- minerals	0.8	1.0	2.2	-1.0	-1.5	0.9	-0.6	-0.7	0.9	1.1	-0.7	1.0	-1.2
Stomach or abdominal pain in last month	0.4	0.5	1.8	1.3	0.5	0.9	-0.5	0.6	-0.5	-0.6	0.8	-0.5	0.4
Supplements: Glucosamine	0.2	0.3	1.9	0.5	0.6	0.4	0.2	-0.1	-0.0	0.0	-0.0	-0.0	-1.4
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	6.2	-0.8	-2.5	-1.4	0.2	0.4	-0.2	-0.2	0.6	-0.2	0.6
Medication: Atenolol	0.5	0.6	3.2	0.3	1.3	0.7	1.8	-0.1	0.2	-0.0	-0.6	-0.1	0.1
Medication: Levothyroxine sodium	1.5	2.5	4.3	1.4	0.1	0.2	0.4	1.9	-2.1	-2.0	1.8	-2.0	1.8
Sitting height	5.8	41.0	72.6	-8.5	-2.8	-7.6	4.5	-6.6	6.6	6.4	-7.7	6.3	-5.0
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	0.6	-0.4	-0.1	1.1	0.6	-0.9	-0.5	0.4	-0.6	-0.9
High blood pressure (mother)	0.7	1.0	1.8	1.4	0.6	0.8	-0.6	0.9	-1.2	-1.1	1.0	-1.0	1.0
Body mass index (BMI)	4.2	17.7	30.8	5.5	1.7	3.5	-0.8	4.9	-5.2	-4.8	4.8	-4.9	3.0
Impedance of leg (left)	7.5	36.3	58.2	-7.6	-1.6	-2.9	0.3	-7.4	7.6	7.2	-7.2	7.3	-5.0
Leg predicted mass (left)	0.2	1.1	4.9	-0.9	-0.7	-2.2	1.8	-0.2	-0.1	-0.2	-0.9	-0.2	-0.7
Trunk fat mass	0.1	0.6	2.9	-0.8	-1.7	-0.9	0.5	-0.1	-0.5	-0.2	-0.3	-0.3	-0.8
Waist circumference	0.3	1.1	2.8	0.8	-0.6	0.6	-0.4	1.3	-1.7	-1.3	0.8	-1.4	1.1
Number of incorrect matches in round	0.2	0.4	1.4	-0.4	0.1	0.4	-0.1	-0.6	0.6	0.7	-0.2	0.8	-1.2
Past tobacco smoking	0.0	0.1	0.4	-0.2	-0.4	-0.6	0.3	0.1	0.0	-0.2	-0.0	-0.1	0.3
Alcohol usually taken with meals	2.8	4.5	6.9	-2.2	1.4	-0.4	2.4	-2.6	2.3	2.6	-2.5	2.5	-0.3
Nervous feelings	0.3	0.6	2.8	-0.5	-0.6	-1.7	1.6	-0.0	0.3	0.1	-0.0	0.1	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.4	-0.4	0.2	-1.9	-1.4	-0.5	1.0	0.6	-0.8	0.7	-0.6
Hearing difficulty/problems with background noise	0.6	1.0	2.1	-1.0	0.0	-0.8	0.6	-0.9	1.3	1.2	-1.4	1.1	-0.9
Hair/balding pattern: Pattern 2	0.7	0.9	3.7	0.7	1.5	1.9	0.1	-0.5	0.4	0.6	-0.3	0.6	-1.3
Had menopause	0.8	1.0	7.2	0.2	0.1	1.3	2.7	0.0	-0.4	0.1	0.6	-0.0	-0.7
Had other major operations	1.3	1.5	8.8	0.9	2.0	0.5	3.0	0.3	-0.6	-0.2	0.2	-0.4	0.9
Forced vital capacity (FVC)	2.5	9.6	16.9	-4.1	-0.6	-4.0	2.9	-3.3	3.2	2.9	-3.9	2.9	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.4	-0.2	0.3	0.6	0.1	-0.1	0.7	-0.0	-0.4	0.2	0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	4.3	0.9	2.1	0.4	1.1	0.1	-0.0	-0.2	-0.0	-0.2	-0.4
Qualifications: None of the above	5.5	11.8	18.6	4.2	0.6	2.0	0.0	4.0	-4.1	-4.2	4.3	-4.2	2.9
Financial difficulties in last 2 years	0.4	0.5	1.9	-0.6	0.1	-0.2	-0.7	-0.7	0.4	0.8	-0.6	0.7	-1.4
Mouth/teeth dental problems	11.0	16.9	25.5	-5.0	-1.7	-4.0	1.9	-4.6	4.3	4.5	-4.8	4.4	-4.5
Heart attack	1.0	1.3	4.2	-0.2	1.5	1.9	-2.0	-0.6	1.0	0.4	-1.0	0.5	-0.1
Allergy	1.4	3.2	6.2	-2.0	1.4	0.9	2.5	-1.9	2.0	1.8	-2.0	1.8	-0.9
Pain all over the body in last month	0.5	0.5	2.3	0.6	-0.3	-0.5	-1.5	0.7	-0.4	-0.7	0.7	-0.7	0.5
Diabetes (self-reported)	0.3	0.4	1.8	0.2	-1.3	0.3	-1.3	0.3	-0.4	-0.1	0.5	-0.2	0.1
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	3.6	1.8	-1.0	-0.1	-1.9	1.8	-1.6	-1.7	1.7	-1.7	-0.0
Medication: Ramipril	1.2	1.6	4.2	1.1	0.2	2.1	1.2	1.4	-1.1	-1.2	1.2	-1.1	1.4
Medication: Simvastatin	0.6	0.8	2.5	0.8	1.1	1.5	-1.6	0.3	-0.2	-0.3	-0.2	-0.3	1.2
Fluid intelligence score	0.7	1.5	6.5	-1.3	0.0	-2.5	0.8	-1.2	1.3	0.8	-1.2	1.0	-0.4
Illnesses of siblings	0.6	0.8	1.5	1.1	0.9	0.9	-0.2	0.9	-0.7	-0.9	1.2	-0.9	0.8
Neuroticism score	0.7	1.4	2.0	-0.8	1.1	-0.9	1.4	-1.2	1.4	1.3	-1.3	1.4	-1.0
Weight	0.1	0.7	3.8	-0.7	-0.5	-1.3	1.9	-0.1	-0.4	-0.1	-0.7	-0.2	-0.5
Impedance of arm (right)	3.1	14.6	27.4	-5.2	-3.2	-2.2	-0.7	-4.4	4.1	4.3	-3.9	4.3	-3.7
Arm fat percentage (right)	1.9	7.5	13.1	3.4	0.1	2.8	-1.1	3.1	-3.6	-3.1	3.2	-3.2	1.2
Trunk fat-free mass	1.4	8.0	20.2	-3.2	0.6	-3.4	4.5	-2.6	2.3	2.1	-3.7	2.1	-1.8
Hip circumference	0.2	1.0	3.7	0.8	1.3	-0.1	1.9	0.6	-1.4	-0.8	0.1	-0.9	-0.5
Time employed in main current job	2.4	2.8	4.7	1.4	0.1	-1.1	2.1	1.8	-2.2	-1.9	1.5	-2.0	1.6
Alcohol intake versus 10 years previously	1.6	2.4	8.0	1.7	1.9	2.8	-1.4	1.0	-0.8	-1.1	1.0	-0.9	1.8
Father’s age at death	1.1	1.5	3.7	1.2	-0.6	0.5	0.3	1.5	-1.9	-1.3	1.6	-1.5	0.8
Worrier / anxious feelings	0.4	0.7	1.7	-1.2	-0.6	-1.3	0.7	-0.8	0.9	0.6	-0.8	0.7	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	3.3	0.7	1.8	0.8	-0.1	0.1	0.1	-0.1	-0.3	-0.1	0.1
Falls in the last year	0.3	0.3	0.8	0.8	0.9	0.8	-0.8	0.4	-0.3	-0.0	0.2	-0.1	0.7
Hair/balding pattern: Pattern 3	1.5	2.2	13.2	-1.1	0.5	-3.6	0.7	-1.3	1.2	1.1	-1.1	1.0	-0.7
Number of live births	0.5	0.7	3.4	1.0	1.9	1.4	-0.3	0.0	-0.2	0.0	0.1	0.0	-0.1
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	9.3	-3.0	-0.4	-3.0	2.0	-2.3	2.2	1.9	-3.0	1.9	0.1
Pulse rate	0.4	0.6	2.2	-1.3	-1.5	-0.3	0.1	-0.6	0.5	0.8	-0.6	0.7	-0.3
Happiness	0.4	0.5	2.9	0.2	1.3	-0.3	1.7	-0.1	0.0	-0.0	-0.1	-0.0	0.4
Noisy workplace	1.8	2.3	3.8	1.7	-0.6	0.6	-0.9	1.8	-1.8	-1.7	1.9	-1.6	1.5
Qualifications: A levels/AS levels or equivalent	6.1	13.6	20.2	-4.4	0.6	-2.7	1.5	-4.4	4.5	4.4	-4.4	4.4	-3.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.4	1.8	-0.3	0.2	0.1	1.4	-1.6	-1.2	1.8	-1.3	0.4
Mouth/teeth dental problems: Dentures	7.1	12.0	17.7	4.2	1.4	3.5	-1.1	3.9	-3.8	-4.0	3.7	-3.9	3.5
Asthma	0.5	0.9	5.5	0.5	-0.9	-1.1	-2.4	0.5	-0.4	-0.3	0.6	-0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	2.9	-0.7	1.7	1.5	0.6	-1.7	1.6	1.6	-1.5	1.6	-1.4
Medication: Cholesterol lowering	0.7	1.1	4.8	-1.0	-0.8	0.6	-2.2	-0.9	0.9	0.8	-1.2	0.8	-0.1
Depression (self-reported)	0.6	0.7	1.9	-0.4	0.4	0.3	-0.0	-0.9	1.4	1.1	-0.8	1.1	-1.1
Medication: Lansoprazole	0.1	0.1	0.4	-0.1	0.6	0.5	-0.4	-0.6	0.1	0.1	-0.5	0.1	-0.1
Prospective memory result	0.2	0.2	1.4	-0.4	-0.6	0.1	1.2	-0.2	0.4	0.4	0.1	0.3	-0.0
Lung cancer (father)	1.0	1.1	4.5	0.8	-0.0	0.4	2.1	0.9	-0.7	-1.1	1.0	-0.9	1.3
Illnesses of mother	1.6	2.0	3.3	-1.8	-0.8	0.0	-0.6	-1.4	1.6	1.8	-1.5	1.6	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	7.5	-2.4	0.3	-2.0	2.1	-2.1	2.0	1.8	-2.7	1.7	-0.2
Pulse wave Arterial Stiffness index	4.3	5.0	8.7	-2.5	-0.6	-0.9	0.7	-2.7	3.0	2.7	-2.3	2.8	-2.4
Impedance of arm (left)	3.1	14.5	28.0	-5.3	-4.1	-3.0	-1.2	-4.1	4.0	4.1	-3.7	4.1	-3.4
Arm fat mass (right)	1.0	4.0	7.9	2.4	0.1	1.2	-0.2	2.4	-2.8	-2.5	2.2	-2.6	0.9
Trunk predicted mass	1.4	8.1	20.0	-3.1	0.7	-3.4	4.5	-2.7	2.3	2.1	-3.7	2.1	-1.8
Standing height	9.4	93.6	174.2	-13.2	-4.6	-10.5	6.1	-10.5	10.1	9.8	-11.7	9.7	-7.4
Length of working week for main job	0.7	0.8	1.2	1.0	0.5	0.4	1.1	1.0	-1.1	-1.1	0.7	-1.1	0.7
Exposure to tobacco smoke at home	1.5	1.7	3.6	1.8	1.1	1.9	0.1	1.4	-1.1	-1.1	1.2	-1.1	1.3
Breastfed as a baby	0.9	1.1	2.0	-1.2	0.6	0.0	1.0	-1.4	1.1	1.1	-1.4	1.2	-1.0
Tense / ‘highly strung’	0.6	1.1	4.6	-0.8	0.1	-2.1	1.4	-0.8	0.9	0.7	-0.9	0.8	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.7	0.3	1.3	0.6	1.1	-0.2	0.3	0.2	-0.2	0.2	0.6
Hair/balding pattern: Pattern 4	1.3	3.1	26.9	-0.5	-1.8	-5.2	0.6	0.3	-0.1	0.1	-0.1	0.0	-0.1
Birth weight of first child	0.3	0.6	3.3	0.4	0.2	-1.0	1.8	0.2	-0.2	-0.6	0.1	-0.4	-0.9
Peak expiratory flow (PEF)	0.4	0.9	4.2	-0.8	0.4	-2.0	0.7	-0.4	0.2	0.2	-1.0	0.0	1.3
Pulse wave reflection index	6.0	7.4	13.0	-2.8	0.5	-1.0	2.4	-3.2	3.6	3.2	-3.1	3.3	-2.3
Ever highly irritable/argumentative for 2 days	0.4	0.4	2.0	0.9	1.4	0.9	-0.5	-0.1	0.4	-0.1	-0.0	0.0	-0.5
Loud music exposure frequency	0.5	0.6	2.2	-0.5	-1.0	-1.5	-0.9	-0.3	0.2	0.3	-0.4	0.3	-1.1
Qualifications: O levels/GCSEs or equivalent	5.1	8.1	15.1	-3.9	-0.9	-2.9	-0.1	-3.3	3.1	3.2	-3.6	3.1	-2.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.3	1.5	0.9	1.5	-0.8	1.1	-0.4	-0.7	1.1	-0.7	1.1
Blood clot in the leg (DVT)	0.9	1.1	2.2	1.2	1.5	0.7	0.3	1.0	-1.0	-1.2	1.1	-1.2	0.9
Medication: Paracetamol	0.5	0.8	4.0	-0.1	2.0	0.1	1.4	-0.8	0.7	0.5	-0.5	0.5	-0.1
Headache pain in last month	0.6	1.1	4.7	0.7	2.2	1.6	1.6	-0.3	0.4	0.2	-0.1	0.3	-0.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.0	-0.4	0.6	-0.3	1.7	-0.9	1.3	1.1	-0.5	1.1	-1.7
Glaucoma (self-reported)	0.2	0.3	2.5	-0.1	0.2	-0.2	-1.6	-0.0	-0.0	-0.2	0.1	-0.2	0.5
Gout (self-reported)	1.0	1.3	3.9	0.9	-0.2	0.1	-2.0	1.0	-1.1	-1.2	0.9	-1.1	1.7
Hypothyroidism/myxoedema (self-reported)	3.1	6.0	10.1	2.7	-0.2	0.6	-0.1	3.0	-3.2	-3.1	3.1	-3.1	2.2
Medication: Amlodipine	4.2	5.9	10.7	2.5	-0.0	0.7	-1.2	2.9	-2.9	-2.8	2.7	-2.9	3.3
Medication: Ventolin 100micrograms inhaler	0.5	0.7	3.2	0.5	-0.6	-0.9	-1.8	0.6	-0.5	-0.4	0.7	-0.4	-0.7
Birth weight	0.5	1.0	8.1	0.2	1.3	0.5	2.9	0.1	-0.2	-0.1	0.0	-0.1	0.3
Chronic bronchitis/emphysema (mother)	1.6	1.9	4.5	1.6	0.7	0.8	-2.1	1.4	-1.3	-1.4	1.4	-1.4	0.9
High blood pressure (siblings)	0.4	0.5	1.0	-0.3	1.0	0.8	0.4	-0.7	0.6	0.7	-1.0	0.6	-1.0
Forced vital capacity (FVC), Best measure	2.0	7.5	12.0	-3.4	-0.2	-3.4	3.2	-2.9	2.8	2.5	-3.5	2.5	-0.8
Body fat percentage	0.3	1.2	2.6	0.9	-1.1	1.2	-0.9	1.1	-1.6	-1.2	1.1	-1.2	-0.2
Leg fat percentage (right)	0.6	2.3	5.6	2.0	0.5	2.4	-0.5	1.5	-1.8	-1.4	1.6	-1.5	0.2
Arm fat-free mass (right)	0.9	4.8	10.8	-2.6	-0.2	-3.3	3.1	-1.9	1.8	1.5	-2.8	1.6	-1.4
Exposure to tobacco smoke outside home	0.4	0.5	1.0	0.9	0.2	0.8	0.1	0.6	-1.0	-0.7	0.4	-0.8	1.0
Comparative body size at age 10	4.9	13.6	20.0	4.4	1.4	1.3	1.1	4.3	-4.5	-4.4	4.2	-4.5	3.9
Number of full brothers	0.3	0.4	1.9	-0.1	-0.8	0.6	-1.4	0.3	0.2	-0.5	-0.0	-0.3	-0.5
Worry too long after embarrassment	7.5	12.6	21.2	-3.7	-0.4	0.3	0.5	-4.4	4.2	4.6	-4.1	4.5	-4.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.7	1.3	0.6	-0.1	1.6	1.2	-1.0	-1.2	1.3	-1.2	1.0
Wheeze or whistling in the chest in last year	1.8	3.2	4.9	2.1	-0.2	0.8	-2.1	2.1	-1.8	-2.2	2.2	-2.0	0.9
Number of children fathered	0.3	0.4	0.9	0.4	-0.4	0.5	-0.3	0.8	-0.6	-1.0	0.7	-0.9	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	5.0	-1.6	-0.3	-0.0	0.3	-1.7	1.7	1.9	-1.9	1.9	-2.2
Age at first live birth	2.0	3.6	6.1	-2.0	-0.2	-0.1	0.3	-2.2	2.5	2.4	-2.4	2.4	-1.8
Pulse wave peak to peak time	2.0	2.4	4.5	1.5	0.2	0.1	-0.7	1.8	-2.1	-2.0	1.4	-2.0	1.9
Health satisfaction	1.1	1.4	6.4	0.5	2.2	2.5	0.3	-0.7	0.5	0.7	-0.7	0.6	-0.2
Shortness of breath walking on level ground	0.2	0.3	0.7	0.4	0.5	0.7	0.5	0.5	-0.5	-0.2	0.1	-0.4	0.8
Qualifications: College or University degree	1.8	5.8	9.5	-2.7	1.0	-1.6	1.3	-2.9	3.0	2.8	-3.1	2.8	-1.6
Eye problems/disorders: None of the above	0.7	0.8	1.5	-1.1	0.3	0.1	1.2	-1.0	0.8	1.0	-1.2	1.0	-0.6
Mouth/teeth dental problems: Loose teeth	2.1	2.5	4.8	-1.9	0.1	-0.3	-0.4	-1.9	2.2	1.9	-1.9	1.9	-1.3
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.1	-0.2	0.8	0.6	-0.0	0.2	0.5	0.0	0.5	-0.6
Medication for pain relief, constipation, heartburn	0.7	1.2	6.8	-0.6	-2.6	-1.9	-0.7	0.3	-0.2	-0.1	0.5	-0.2	0.1
Neck or shoulder pain in last month	1.8	2.6	4.6	2.1	1.7	1.2	0.6	1.9	-1.5	-1.7	1.8	-1.7	1.5
Medication: Blood pressure	3.1	5.4	10.1	2.2	0.3	0.5	-0.2	2.7	-3.0	-2.9	2.3	-2.9	3.2
Angina (self-reported)	0.3	0.3	1.5	-0.1	0.2	0.9	-0.8	0.2	-0.2	-0.2	-0.4	-0.3	1.2
Migraine (self-reported)	0.8	1.0	2.8	-0.1	1.7	1.6	0.3	-0.9	1.0	0.7	-0.7	0.8	-1.2
Medication: Ibuprofen	1.1	1.3	3.9	-0.0	2.0	1.9	0.1	-1.1	0.9	1.0	-0.8	1.0	-0.9
Medication: Allopurinol	0.3	0.4	0.9	0.8	-0.0	0.0	-0.3	0.5	-0.7	-0.6	0.5	-0.6	1.0
Medication: Omeprazole	2.6	3.1	5.4	-1.4	1.0	-0.2	-0.4	-1.8	2.2	2.1	-2.3	2.1	-2.3
Medication: Seretide 50 evohaler	1.1	1.3	2.4	1.4	-0.4	-0.4	-1.0	1.6	-1.2	-1.1	1.4	-1.2	1.0
Mean time to correctly identify matches	0.7	1.3	5.3	1.5	1.7	2.3	0.7	0.9	-0.6	-0.6	0.6	-0.6	0.3
Heart disease (mother)	2.4	3.0	6.1	1.4	0.7	-1.7	1.3	1.6	-1.8	-2.1	1.4	-2.1	2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.4	1.5	0.8	0.5	-1.2	0.8	-0.9	-0.9	1.2	-0.9	0.2
Whole body fat mass	0.1	0.6	1.6	0.4	-1.1	0.0	0.1	0.8	-1.3	-1.0	0.6	-1.0	-0.4
Leg fat mass (right)	0.3	1.2	2.6	1.4	0.1	1.1	0.0	1.3	-1.6	-1.3	1.0	-1.4	0.0
Arm predicted mass (right)	0.9	4.6	10.8	-2.5	-0.1	-3.3	3.1	-1.9	1.7	1.4	-2.7	1.5	-1.3
Pulse rate, automated reading	1.8	5.9	11.1	-3.3	-2.1	-1.9	-0.2	-2.4	2.8	2.7	-2.5	2.8	-2.1
Alcohol intake frequency.	1.2	2.8	4.9	2.2	1.7	1.2	-0.3	1.9	-1.7	-2.0	1.6	-2.0	1.3
Comparative height size at age 10	8.2	45.3	80.1	-8.9	-2.7	-7.2	5.3	-7.4	6.9	6.7	-8.2	6.7	-5.2
Number of full sisters	1.0	1.2	2.3	1.3	0.1	-0.1	0.0	1.3	-1.4	-1.5	1.4	-1.4	0.7
Suffer from ‘nerves’	0.3	0.5	2.1	0.5	0.6	-1.2	1.4	0.4	0.1	-0.5	0.4	-0.3	-0.4
Overall health rating	1.6	3.5	5.8	2.4	0.8	2.2	-1.4	2.1	-2.0	-2.0	1.8	-2.0	1.5
Chest pain or discomfort	0.1	0.1	0.6	-0.0	-0.1	-0.4	-0.7	0.0	0.3	-0.1	-0.0	0.0	-0.6
Had major operations	0.3	0.3	1.3	0.0	1.1	0.9	0.3	-0.0	-0.2	-0.2	0.0	-0.2	0.8
Age at last live birth	1.2	1.8	3.5	-1.5	-0.6	-0.7	-0.1	-1.5	1.6	1.9	-1.6	1.8	-0.9
Family relationship satisfaction	0.6	0.8	2.6	-1.1	-0.0	-0.3	1.6	-0.8	0.7	0.9	-0.9	0.8	0.4
Leg pain on walking	0.3	0.4	1.0	0.8	0.0	-0.6	-0.3	0.8	-1.0	-0.6	0.6	-0.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.3	0.0	1.7	1.5	-1.8	-0.4	0.8	0.7	-0.8	0.7	-0.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.4	1.3	1.9	0.3	0.4	0.5	-0.6	-0.9	0.6	-0.7	-0.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.9	-1.3	0.3	0.3	0.7	-1.4	1.5	1.4	-1.7	1.4	-1.3
Medication: Aspirin	1.0	1.3	2.4	1.2	1.5	1.5	-0.9	1.0	-0.8	-1.0	0.5	-1.0	1.3
Supplements: Vitamin C	0.4	0.5	1.0	-0.6	-1.0	-1.0	0.4	0.3	-0.9	-0.5	0.5	-0.7	0.6
Knee pain experienced in last month	0.8	1.3	2.3	1.4	1.5	1.1	-1.0	1.0	-1.4	-1.0	0.7	-1.2	0.7
Hypertension (Self-reported)	3.4	9.5	14.8	3.6	1.3	1.3	0.4	3.7	-3.9	-3.7	3.1	-3.8	3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	2.6	-0.0	-0.3	0.8	-0.6	-0.6	0.7	0.6	-0.5	0.6	-1.6
Illnesses of father: Heart disease	1.8	2.5	4.0	-2.0	-1.3	-1.6	-0.4	-1.7	2.0	1.7	-1.8	1.8	-0.8
Illnesses of siblings: Diabetes	0.4	0.4	1.7	0.5	0.3	1.1	-1.3	0.4	-0.6	-0.4	0.1	-0.5	0.1
Smoking status: Previous	0.1	0.2	0.4	0.3	-0.4	-0.1	-0.3	0.5	-0.5	-0.5	0.6	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	5.2	10.9	20.1	-4.4	-1.6	-4.5	0.2	-3.6	3.6	3.3	-4.1	3.3	-1.6
Whole body fat-free mass	0.8	4.5	11.6	-2.4	0.0	-3.2	3.4	-1.7	1.4	1.2	-2.6	1.2	-1.4
Leg fat-free mass (right)	0.3	1.5	7.7	-1.2	-1.1	-2.8	1.9	-0.3	-0.1	-0.1	-0.9	-0.1	-0.5
Arm fat percentage (left)	2.0	8.1	14.5	3.3	-0.5	2.4	-1.5	3.4	-3.8	-3.3	3.4	-3.4	1.5
Average weekly red wine intake	0.6	0.9	5.1	0.1	2.2	-0.4	1.7	-0.0	-0.2	0.1	-0.5	-0.1	1.0
Handedness (chirality/laterality): Left-handed	1.9	2.3	3.7	-1.9	-0.7	-1.1	-1.9	-1.6	1.7	1.5	-1.9	1.5	-0.9
Mood swings	0.6	1.0	4.8	1.2	2.2	1.7	-0.6	0.1	0.3	-0.1	0.1	0.1	-0.7
Loneliness, isolation	1.2	1.6	3.8	1.9	1.1	-0.4	1.4	1.5	-1.3	-1.3	1.4	-1.2	0.3
Long-standing illness, disability or infirmity	2.8	4.2	6.7	2.5	0.1	1.2	-1.2	2.6	-2.4	-2.2	2.4	-2.3	2.1
Ever had bowel cancer screening	0.1	0.2	0.5	0.4	-0.0	0.1	0.1	0.5	-0.5	-0.5	0.4	-0.7	0.1
Diabetes diagnosed by doctor	0.4	0.7	3.5	-0.2	-1.9	-0.3	-1.8	0.3	-0.4	-0.1	0.4	-0.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	2.5	2.6	3.7	-0.7	1.5	1.7	-0.3	-1.8	1.9	1.9	-1.8	1.9	-1.8
Friendships satisfaction	0.6	0.8	4.0	-0.4	0.3	-1.2	2.0	-0.6	0.7	0.5	-0.4	0.6	0.5
Qualifications: nursing, teaching	0.8	1.3	1.9	-1.3	-0.2	-1.2	0.9	-1.2	1.4	1.3	-1.1	1.3	-1.0
Commuting to job workplace: Walk	1.3	1.4	3.0	-1.6	-1.7	-1.4	-0.1	-0.9	0.8	1.4	-1.0	1.1	-1.1
Eye problems/disorders: Cataract	0.7	0.9	2.1	1.4	0.8	0.1	-0.0	1.0	-0.9	-1.1	0.9	-1.1	0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.8	0.8	-0.1	1.2	-0.5	1.0	-0.8	-0.8	1.4	-0.8	1.0
Medication for cholesterol	3.7	5.5	8.7	-2.9	-1.5	-2.0	-0.2	-2.6	2.5	2.6	-2.3	2.7	-2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	7.4	8.7	15.2	3.5	1.8	1.3	1.5	3.2	-3.5	-3.1	3.0	-3.2	3.9
Back pain experienced in last month	0.6	0.8	4.2	1.0	1.1	2.0	-0.1	0.3	-0.3	-0.4	0.6	-0.4	0.9
Mineral and other dietary supplements	0.6	0.8	2.2	0.1	-1.2	-1.5	-0.7	0.6	-0.4	-0.7	0.7	-0.6	1.3
Breast cancer (self-reported)	0.7	0.8	4.5	-0.7	1.2	0.1	2.1	-0.6	0.4	0.7	-0.7	0.5	-0.1
Asthma (self-reported)	0.4	0.7	4.2	0.7	-0.7	-0.8	-2.1	0.5	-0.6	-0.3	0.7	-0.4	-0.5
Osteoporosis (self-reported)	1.8	2.2	3.4	1.7	0.9	1.0	1.9	1.7	-1.5	-1.6	1.4	-1.6	1.4
Osteoarthritis (self-reported)	2.4	3.1	6.8	2.6	1.4	1.4	-0.6	1.8	-2.2	-1.8	1.7	-1.9	1.5
Medication: Aspirin	0.7	1.0	3.0	0.9	1.7	1.4	-0.7	0.6	-0.6	-0.7	0.2	-0.7	1.3
Medication: Gliclazide	1.3	1.5	6.0	-1.6	-2.4	-2.2	-0.2	-0.5	0.4	0.5	-0.4	0.5	-0.0
Illnesses of father: None of the above (group 1)	1.2	1.5	3.6	-1.2	1.0	0.1	1.9	-1.4	1.4	1.2	-1.3	1.3	-0.8
Smoking status: Current	0.3	0.4	1.0	1.0	1.0	0.7	-0.5	0.5	-0.5	-0.5	0.6	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.9	-0.0	0.4	1.4	0.6	-0.3	0.3	0.2	-0.6	0.1	-0.0
Whole body water mass	0.7	4.0	12.1	-2.2	0.1	-3.1	3.5	-1.5	1.2	1.1	-2.4	1.1	-1.2
Leg predicted mass (right)	0.3	1.4	7.3	-1.1	-1.0	-2.7	1.8	-0.2	-0.1	-0.2	-0.9	-0.2	-0.4
Arm fat mass (left)	1.1	4.6	9.2	2.5	-0.2	1.1	-0.0	2.6	-3.0	-2.7	2.4	-2.8	1.2
Number of self-reported non-cancer illnesses	2.3	4.0	9.4	3.1	1.3	1.3	-0.7	2.2	-2.2	-2.3	2.2	-2.3	1.2
Average weekly champagne plus white wine intake	2.7	3.7	5.4	-2.3	-1.6	-2.1	1.8	-2.1	1.9	2.3	-1.7	2.2	-1.0
Miserableness	0.2	0.4	1.7	0.5	1.0	-0.8	1.3	0.3	-0.2	-0.0	-0.1	-0.2	0.3
Guilty feelings	0.5	0.8	4.6	0.4	2.1	-0.7	0.5	-0.4	0.6	0.5	-0.8	0.5	-0.7
Wears glasses or contact lenses	0.4	0.4	3.1	-0.3	-0.6	1.8	-0.6	0.0	-0.1	0.3	-0.4	0.2	-0.4
Ever taken oral contraceptive pill	2.4	2.6	5.0	-2.2	0.7	-1.3	0.4	-1.9	2.0	1.8	-2.1	1.8	-0.6
Hearing aid user	1.6	1.8	6.1	0.9	-0.4	-1.6	2.5	1.3	-1.4	-1.0	1.1	-1.1	0.8
Mother’s age at death	0.6	0.7	1.4	0.1	-1.0	-0.8	-0.5	0.9	-1.2	-0.8	1.0	-0.9	0.7
Financial situation satisfaction	1.9	2.3	3.9	-1.7	0.0	0.3	0.7	-1.9	1.6	2.0	-1.9	1.9	-1.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.8	-0.7	-1.9	-1.2	-0.6	-0.3	0.6	0.5	-0.1	0.5	-0.6
Commuting to job workplace: Public transport	1.2	1.4	2.9	-1.7	-1.4	-1.4	-0.5	-1.1	1.0	1.2	-1.3	1.1	-0.9
Eye problems/disorders: Glaucoma	0.7	0.9	3.2	-0.7	-0.8	-1.4	-1.8	-0.8	0.6	0.5	-0.4	0.5	-0.9
Medication: Blood pressure	1.7	3.2	6.5	2.1	1.1	1.6	0.1	2.0	-1.8	-1.9	1.5	-1.9	2.5
Pain type(s) experienced in last month: Hip pain	2.2	2.8	4.9	1.5	-0.1	-0.7	1.1	2.1	-2.0	-2.2	2.1	-2.2	1.3
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.3	-0.9	0.0	0.7	0.6	-0.8	0.7	0.9	-0.7	0.8	-1.1
High cholesterol (Self-reported)	0.8	1.4	5.2	-0.7	-1.0	0.3	-2.3	-1.0	1.2	1.1	-1.0	1.2	-0.9
Medication: Bendroflumethiazide	5.0	7.6	12.2	2.8	-0.1	-0.3	-0.7	3.4	-3.3	-3.5	3.0	-3.5	3.5
Medication: Paracetamol	0.4	0.6	3.6	0.0	1.9	0.5	1.1	-0.6	0.5	0.4	-0.4	0.4	0.2
Medication: Lisinopril	0.4	0.6	2.0	-0.6	0.6	0.0	-1.4	-0.9	0.6	0.7	-1.0	0.6	-0.2
Medication: Atorvastatin	0.5	0.6	2.2	-0.2	-0.4	0.8	-1.3	-0.5	0.7	0.4	-0.4	0.5	-1.5
Illnesses of father: High blood pressure	1.6	1.9	5.3	2.1	0.1	0.9	-2.3	1.4	-1.2	-1.3	1.3	-1.3	0.3
Alcohol drinker status: Never	0.5	0.6	2.7	0.7	1.0	1.6	-0.6	0.3	-0.4	-0.6	0.2	-0.7	0.4
Ever smoked	0.1	0.1	0.4	-0.1	-0.0	-0.2	-0.4	-0.1	0.2	0.3	-0.2	0.2	-0.7
Basal metabolic rate	0.6	3.2	8.8	-2.0	-0.2	-2.8	3.0	-1.4	1.1	0.9	-2.2	0.9	-1.2
Leg fat percentage (left)	0.6	2.1	3.8	1.8	0.1	1.9	-0.4	1.6	-1.9	-1.5	1.6	-1.6	0.5
Arm fat-free mass (left)	0.8	4.0	12.4	-2.1	0.6	-2.6	3.5	-1.7	1.5	1.3	-2.5	1.3	-1.1
Number of operations (self-reported)	3.0	4.4	7.0	2.5	1.7	0.8	1.4	2.3	-2.5	-2.1	2.0	-2.4	2.6
Average weekly beer plus cider intake	0.4	0.6	1.7	0.7	-0.3	1.3	-0.0	0.8	-0.9	-1.0	0.8	-0.9	0.6
Irritability	0.1	0.1	0.5	0.4	0.7	-0.0	-0.7	-0.2	0.3	0.2	-0.1	0.2	0.2
Risk taking	0.1	0.2	0.9	0.4	0.2	-0.5	-1.0	0.4	-0.1	-0.4	0.4	-0.2	0.3
Ever had prostate specific antigen (PSA) test	1.3	1.5	6.0	-1.7	-0.1	-0.6	2.5	-1.0	0.9	1.0	-0.9	0.9	-0.9
Fractured/broken bones in last 5 years	0.2	0.3	1.0	-0.5	-1.0	-0.7	-0.8	-0.1	0.0	0.2	-0.4	0.2	0.0
Age started oral contraceptive pill	0.8	1.0	4.9	-0.6	-0.8	-2.2	2.1	0.2	0.1	-0.0	-0.0	-0.0	-0.4
Diastolic blood pressure, automated reading	0.6	2.0	10.9	1.4	3.3	1.9	-1.4	-0.1	-0.0	-0.7	-0.3	-0.5	0.7
Ever depressed for a whole week	0.7	0.8	2.6	-0.4	1.6	-0.3	1.4	-0.8	0.7	0.7	-1.0	0.6	-0.5
Unable to work because of sickness or disability	2.9	3.7	6.6	2.3	-0.4	0.9	0.6	2.6	-2.5	-2.0	2.6	-2.2	1.5
Commuting to job workplace: Cycle	0.5	0.6	2.3	-0.4	-0.8	-1.2	1.5	-0.5	0.7	0.6	-0.5	0.6	-0.2
Myopia	0.2	0.4	1.8	0.5	0.4	1.0	-1.3	0.2	-0.4	0.1	-0.2	-0.1	0.5
Vascular/heart problems diagnosed by doctor	2.9	8.0	11.7	-3.4	-2.4	-2.2	-0.3	-3.0	3.3	3.3	-2.3	3.3	-3.3
Cholesterol lowering medication	0.7	1.0	1.8	1.4	0.1	1.1	-1.1	1.1	-0.7	-0.9	1.1	-0.9	1.0
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	5.8	-1.8	0.5	-0.9	-0.4	-1.9	2.3	2.2	-2.4	2.1	-2.1
Pain experienced in last month	0.2	0.3	1.3	-0.5	-1.0	-1.2	0.5	0.3	-0.2	-0.2	0.0	-0.3	0.3
Supplements: Calcium	0.7	0.8	2.6	1.1	1.1	1.6	-0.1	0.8	-0.9	-0.5	0.7	-0.6	0.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	0.5	-0.5	0.4	0.5	0.8	-1.3	-0.8	0.8	-1.0	0.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	4.1	-0.2	1.3	2.0	-2.0	-0.6	1.0	0.5	-1.0	0.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.6	1.2	1.6	0.8	0.2	0.9	-0.9	-1.1	0.9	-1.1	0.8
Heart disease (siblings)	0.8	1.0	1.6	0.9	-0.5	-0.6	0.5	1.1	-1.2	-1.2	0.8	-1.2	1.3
Alcohol drinker status: Previous	0.2	0.2	1.0	0.4	0.2	-1.0	0.9	0.4	-0.1	-0.2	0.3	-0.2	-0.3
Pack years of smoking	0.4	0.6	1.3	-0.4	1.1	1.1	1.2	-0.7	0.7	0.7	-0.5	0.7	-0.5
Impedance of whole body	5.5	28.0	49.3	-7.0	-3.1	-3.2	-0.6	-6.2	6.3	6.1	-5.9	6.2	-4.7
Leg fat mass (left)	0.4	1.4	3.1	1.4	-0.1	1.0	0.0	1.4	-1.8	-1.5	1.2	-1.6	0.3
Arm predicted mass (left)	0.8	4.3	14.3	-2.1	0.7	-2.6	3.8	-1.7	1.5	1.3	-2.5	1.3	-1.2