TWAS hub - CAPN10-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1400	0.0530	0.0076	-0.004	NA	-0.005	NA	0.001	5.8e-01	NA	8.4e-01	NA	2.6e-01
2	GTEx	Skin Sun Exposed Lower leg	0.1360	0.0450	0.0005	0.005	NA	0.007	NA	0.003	1.1e-01	NA	7.2e-02	NA	1.6e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.0545	0.0193	0.0013	0.061	0.012	0.036	0.034	0.047	2.4e-08	0.0083	1.6e-05	3e-05	1.1e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Chronic bronchitis/emphysema (mother)	4.4	5.1	10.8	3.3	2.0	0.7
Impedance of arm (right)	4.2	19.8	37.8	6.2	4.6	0.1
Impedance of arm (left)	3.5	16.3	31.7	5.6	4.1	0.2
Verbal and Numeric Reasoning (VNR)	3.2	7.6	12.2	-3.5	-0.1	3.2
Qualifications: O levels/GCSEs or equivalent	2.9	4.6	10.8	1.3	1.1	3.3
Impedance of whole body	2.9	14.7	31.2	5.6	3.5	-0.7
Commuting to job workplace: Cycle	2.6	3.1	7.1	-0.0	-1.5	-2.7
Exposure to tobacco smoke outside home	2.4	3.2	8.3	2.9	1.0	-0.7
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	4.4	-1.5	-1.4	-2.1
Mean Putamen Volume	2.3	2.6	3.1	-1.3	-1.8	-1.8
Alzheimer’s Disease (in father)	2.2	2.4	6.8	-0.3	2.6	0.5
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.0	10.4	3.2	1.9	0.9
Number of live births	2.1	2.9	4.3	-2.1	-2.0	-0.6
Hair/balding pattern: Pattern 4	2.1	5.0	13.8	-3.7	-1.1	-0.1
Medication: Omeprazole	2.1	2.5	3.6	-1.1	-1.7	-1.9
Ever taken oral contraceptive pill	2.1	2.3	6.3	0.7	2.5	-0.4
Bipolar Disorder or Schizophrenia	2.0	4.9	9.5	3.1	1.8	-1.4
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	4.9	1.0	2.2	0.9
Supplements: Calcium	2.0	2.2	5.1	1.0	2.3	0.7
Crohns Disease (2012)	1.9	3.1	8.4	0.5	-0.8	-2.9
Pulse rate	1.9	3.2	8.4	-1.1	-0.4	2.9
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	4.2	-1.7	-0.2	-2.0
Number of treatments/medications taken	1.7	3.0	7.4	-2.7	-0.6	-1.1
Fluid intelligence score	1.7	3.5	7.8	-2.8	-0.8	1.5
Medication: Lansoprazole	1.7	1.9	5.4	-2.3	0.2	-0.6
Medication: Seretide 50 evohaler	1.7	2.0	3.6	-1.4	-1.9	0.7
Schizophrenia (2018)	1.6	3.3	7.7	2.8	1.3	-0.7
Schizophrenia (2014)	1.6	3.6	7.5	2.7	0.9	-1.6
Pack years adult smoking proportion	1.6	2.4	4.3	1.7	2.1	0.3
Impedance of leg (right)	1.6	7.6	18.5	4.3	1.8	-1.0
Impedance of leg (left)	1.6	7.7	16.6	4.1	2.1	-1.4
Leg pain on walking	1.6	2.1	3.8	1.9	0.7	1.4
Risk taking	1.6	2.4	2.8	1.7	1.6	-1.3
Intelligence (Savage-Jansen 2018)	1.5	4.6	9.3	-2.1	0.1	3.0
Hair/balding pattern: Pattern 3	1.5	2.2	3.6	-1.0	-1.4	1.9
Arm predicted mass (right)	1.5	7.9	20.8	-4.6	-1.6	0.7
Eye problems/disorders: Cataract	1.5	1.7	4.8	2.2	0.6	0.1
Hair/balding pattern: Pattern 2	1.4	1.7	1.9	-1.4	-1.2	-1.3
Forced vital capacity (FVC)	1.4	5.3	14.7	-0.6	3.8	0.8
Father’s age at death	1.4	1.8	2.3	-1.4	-1.5	1.2
Arm fat-free mass (right)	1.4	7.2	18.8	-4.3	-1.5	0.6
Commuting to job workplace: Walk	1.4	1.5	2.3	-0.9	-1.5	-1.1
Osteoporosis (self-reported)	1.4	1.7	3.7	-1.9	0.3	-1.1
Financial situation satisfaction	1.4	1.7	3.0	0.8	-1.7	-1.2
Medication: Blood pressure	1.4	2.6	3.7	-1.4	-1.9	-1.4
Pack years of smoking	1.4	2.0	3.7	1.5	1.9	0.4
Rheumatoid Arthritis	1.3	1.8	4.9	-0.7	2.2	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	2.7	0.5	-1.4	-1.6
Body mass index (BMI)	1.3	5.6	13.3	-3.6	-1.4	1.2
Waist circumference	1.3	4.7	11.9	-3.5	-0.7	1.2
Hip circumference	1.3	5.4	12.7	-3.6	0.6	1.8
Eye problems/disorders: None of the above	1.3	1.5	2.7	-1.3	-0.4	-1.6
Had major operations	1.3	1.5	4.5	-2.1	-0.4	0.1
Average weekly beer plus cider intake	1.3	1.9	3.1	0.5	1.5	1.8
Arm predicted mass (left)	1.3	6.8	17.7	-4.2	-1.4	0.8
Bipolar Disorder (2018)	1.2	2.0	2.1	1.5	1.4	-1.4
Heel T-Score	1.2	9.6	23.3	4.8	2.0	-1.1
BMI	1.2	7.1	21.0	-4.6	-0.1	0.6
Trunk fat-free mass	1.2	6.6	17.3	-4.2	-0.8	1.4
Worrier / anxious feelings	1.2	2.2	3.0	-1.7	-1.0	-1.7
Prospective memory result	1.2	1.5	4.3	2.1	0.1	-0.5
Blood clot in the leg (DVT)	1.2	1.6	2.6	0.2	1.6	1.4
Forced vital capacity (FVC), Best measure	1.2	4.2	10.0	-1.1	3.2	1.2
Medication: Aspirin	1.2	1.6	2.2	-1.5	-1.0	-1.2
Whole body fat-free mass	1.2	6.8	17.8	-4.2	-0.7	1.5
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.7	-1.9	-0.6	-0.2
Long-standing illness, disability or infirmity	1.2	1.8	5.2	-2.3	-0.0	-0.4
Osteoarthritis (self-reported)	1.2	1.5	4.1	-2.0	-0.6	0.1
Number of self-reported non-cancer illnesses	1.2	2.0	6.0	-2.4	0.1	0.1
Guilty feelings	1.2	1.8	3.3	-1.8	-0.5	-1.3
Arm fat-free mass (left)	1.2	5.9	15.7	-4.0	-1.3	0.6
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.3	0.2	1.5	1.5
Heart disease (siblings)	1.2	1.5	4.1	-2.0	0.7	-0.1
Breast Cancer	1.1	2.6	5.2	2.3	1.6	0.0
Lung FEV1/FVC ratio	1.1	5.4	6.6	-1.8	-2.6	-2.5
Taking other prescription medications	1.1	1.6	4.9	-2.2	0.2	-0.0
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.4	-0.3	-1.5	-1.0
Had other major operations	1.1	1.3	3.1	-0.1	0.9	1.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.1	-1.1	-1.1	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.5	-1.1	-1.6	-1.4
Illnesses of mother	1.1	1.3	2.5	-1.6	-0.8	-0.9
Trunk predicted mass	1.1	6.5	17.2	-4.2	-0.8	1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.9	0.0	1.2	1.7
Supplements: Vitamin C	1.1	1.3	1.8	1.3	1.2	-0.8
Friendships satisfaction	1.1	1.4	2.7	1.1	-1.7	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.4	-1.2	-0.4	-1.6
Whole body water mass	1.1	6.3	16.6	-4.1	-0.7	1.4
Wears glasses or contact lenses	1.1	1.3	3.8	-1.9	-0.2	0.2
Basal metabolic rate	1.1	6.0	15.7	-4.0	-0.5	1.4
Leg fat mass (left)	1.1	4.2	10.6	-3.2	-0.8	1.1
Prostate Cancer	1.0	1.4	3.5	-0.4	-0.7	-1.9
Coronary Artery Disease (CAD)	1.0	1.2	2.0	1.4	0.6	-1.1
Fasting Glucose	1.0	1.2	2.8	0.2	1.7	0.9
Diabetes (mother)	1.0	1.3	3.6	-1.9	-0.4	0.2
Leg fat-free mass (left)	1.0	5.4	14.0	-3.7	-0.3	1.5
Stomach or abdominal pain in last month	1.0	1.2	1.6	1.2	-1.3	-0.8
Leg predicted mass (left)	1.0	5.3	13.7	-3.7	-0.3	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	6.2	2.5	0.8	0.4
Loud music exposure frequency	1.0	1.1	2.4	0.6	0.6	-1.6
Comparative body size at age 10	1.0	2.8	5.0	-2.2	-1.8	0.2
Leg fat mass (right)	1.0	4.0	9.5	-3.1	-0.8	1.4
Leg fat-free mass (right)	1.0	5.3	14.0	-3.7	-0.1	1.4
Leg predicted mass (right)	1.0	5.4	14.4	-3.8	-0.1	1.3
Schizophrenia vs Biploar Disorder	0.9	1.2	2.5	1.6	1.0	-0.1
Crohns Disease (2017)	0.9	2.1	2.9	0.9	-1.6	-1.7
Ulcerative Colitis	0.9	1.2	1.9	1.2	0.6	-1.4
Ever had hysterectomy (womb removed)	0.9	1.0	1.9	-1.0	-1.4	-0.4
Age when periods started (menarche)	0.9	2.3	3.5	1.9	1.8	-0.2
Medication: Levothyroxine sodium	0.9	1.6	2.7	-1.4	-1.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.1	-0.8	-1.3	-1.4
Allergy	0.9	2.0	4.9	1.0	-0.3	-2.2
Illnesses of siblings	0.9	1.2	3.0	1.7	-0.1	-0.8
Weight	0.9	4.4	11.3	-3.4	-0.2	1.4
Peak expiratory flow (PEF)	0.9	2.1	4.4	-0.9	2.1	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.7	-0.4	-1.2	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.6	0.9	2.1	-0.6
Medication: Gliclazide	0.9	1.1	1.9	1.1	0.4	-1.4
Mother’s age at death	0.9	1.1	2.6	1.6	0.3	0.8
Number of operations (self-reported)	0.9	1.3	3.0	-0.8	-0.5	1.7
Neuroticism (2016)	0.8	1.2	2.9	0.7	0.4	-1.7
Blood Platelet Count	0.8	8.9	18.6	-2.7	-1.0	-4.3
Lung FVC	0.8	4.3	5.7	-1.9	1.9	2.4
Average weekly spirits intake	0.8	1.0	2.6	0.3	0.6	1.6
Medication: Co-codamol	0.8	0.9	2.2	-0.6	-1.5	-0.2
Diabetes (father)	0.8	1.0	3.0	0.1	1.7	-0.2
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	8.0	-0.4	2.8	0.3
Asthma	0.8	1.6	3.0	-1.7	0.3	1.3
Exposure to tobacco smoke at home	0.8	0.9	2.3	1.5	0.4	0.5
Shortness of breath walking on level ground	0.8	1.0	1.8	-0.6	-0.9	1.4
Qualifications: College or University degree	0.8	2.4	5.3	-2.3	-1.1	-0.9
Age at last live birth	0.8	1.1	2.0	-1.4	-1.1	-0.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.1	-1.4	-0.9	-0.2
Ever had bowel cancer screening	0.8	1.0	2.0	0.5	1.4	0.9
Medication: Aspirin	0.8	1.1	1.8	-1.3	-0.9	-0.8
Ever smoked	0.8	1.3	2.4	1.6	0.8	1.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.4	-0.3	-0.6	-1.6
Worry (Nagel 2018)	0.7	1.5	2.2	-0.8	-1.2	-1.5
Irritable Bowel Disease (IBD)	0.7	1.7	2.9	1.7	-0.2	-1.5
HbA1C	0.7	0.8	1.4	-0.0	-1.0	1.2
Allergy or Eczema	0.7	1.8	4.9	-0.2	0.5	2.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.6	-0.2	-1.3	-1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.9	-0.5	-1.4	-0.5
Hayfever, allergic rhinitis or eczema	0.7	1.6	4.7	-0.2	0.4	2.2
Number of incorrect matches in round	0.7	1.1	2.8	0.0	0.7	-1.7
Time employed in main current job	0.7	0.8	1.3	0.3	-1.0	-1.1
Falls in the last year	0.7	1.0	2.8	-0.2	-0.2	-1.7
Happiness	0.7	0.8	1.6	0.9	-1.2	-0.0
Tense / ‘highly strung’	0.7	1.1	2.5	-0.0	-1.0	-1.6
Leg fat percentage (right)	0.7	2.4	4.6	-2.1	-1.1	1.2
Mean time to correctly identify matches	0.7	1.3	3.3	0.4	-1.8	0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.0	0.5	0.5	1.4
Medication for cholesterol	0.7	1.1	2.2	1.5	0.1	1.0
Asthma (self-reported)	0.7	1.5	2.4	-1.6	0.8	1.2
Commuting to job workplace: Public transport	0.7	0.8	1.8	-0.2	-0.7	1.3
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.4	-0.5	-1.6	0.1
Medication: Lisinopril	0.7	1.0	2.4	-0.5	-1.6	0.5
Ulcerative Colitis (UC)	0.6	1.2	2.0	1.4	0.8	-0.9
Ovarian Cancer	0.6	0.8	2.3	0.3	1.5	0.3
Body Mass Index (BMI) (2010)	0.6	0.8	1.3	-1.0	0.4	1.1
LDL Cholesterol	0.6	1.0	2.6	-0.3	0.5	1.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.0	-1.0	0.3	1.0
Hand grip strength (left)	0.6	1.6	3.3	-1.8	-1.1	0.3
Maternal smoking around birth	0.6	0.9	2.7	1.7	0.0	-0.0
Relative age voice broke	0.6	0.9	2.3	0.5	0.3	1.5
Serious illness, injury or assault to yourself	0.6	0.7	1.2	-1.0	1.1	0.2
Multivitamins +/- minerals	0.6	0.7	1.2	-0.3	-0.9	-1.1
High blood pressure (mother)	0.6	0.9	1.6	1.2	-0.9	-0.5
Alcohol usually taken with meals	0.6	1.0	1.5	1.0	-0.8	-1.2
Had menopause	0.6	0.8	1.9	-0.2	-1.4	-0.6
Alcohol intake versus 10 years previously	0.6	0.9	2.6	0.2	0.1	-1.6
Depression (self-reported)	0.6	0.7	1.3	0.6	-0.6	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	5.2	-0.6	2.3	0.3
Arm fat mass (right)	0.6	2.4	5.1	-2.3	-0.0	1.5
Heart disease (mother)	0.6	0.8	1.3	0.6	-0.8	1.1
Whole body fat mass	0.6	2.5	5.4	-2.3	0.2	1.4
Overall health rating	0.6	1.2	1.7	-1.3	-0.6	-1.3
Mood swings	0.6	1.2	2.1	-1.2	-1.4	0.3
Diabetes diagnosed by doctor	0.6	1.0	2.7	-1.6	-0.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	1.8	-1.3	1.3	0.5
Arm fat mass (left)	0.6	2.5	5.5	-2.3	-0.0	1.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	-0.8	1.2	0.3
Medication: Paracetamol	0.6	0.9	1.1	-0.8	-1.1	-1.0
Alcohol drinker status: Never	0.6	0.7	1.9	-1.4	-0.3	0.4
Leg fat percentage (left)	0.6	2.3	5.2	-2.3	-1.0	0.9
Unable to work because of sickness or disability	0.6	0.7	1.4	-0.8	0.3	-1.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	1.2	-0.2	0.9
Triglycerides	0.5	0.8	1.3	-0.8	-0.6	1.1
Blood Red Count	0.5	5.1	14.7	0.8	0.0	3.8
Cardiovascular Disease	0.5	1.6	4.0	-2.0	0.9	-0.1
Respiratory disease	0.5	1.1	1.6	-1.1	0.8	1.3
Angina	0.5	0.6	1.8	-0.1	1.4	0.1
Medication: Metformin	0.5	0.8	1.4	-0.1	0.9	-1.2
Hand grip strength (right)	0.5	1.3	3.4	-1.9	-0.6	-0.2
Townsend deprivation index at recruitment	0.5	0.7	2.0	-0.5	-0.2	1.4
Trunk fat mass	0.5	2.1	2.9	-1.7	0.7	1.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	-0.8	-1.0	0.4
Financial difficulties in last 2 years	0.5	0.7	1.2	1.1	-0.5	0.7
Diabetes (self-reported)	0.5	0.8	1.4	-1.2	0.2	0.9
Medication: Ramipril	0.5	0.7	1.0	-1.0	0.3	-1.0
Medication: Simvastatin	0.5	0.7	0.7	-0.8	-0.8	-0.8
Noisy workplace	0.5	0.6	0.9	0.3	-1.0	-0.9
Length of working week for main job	0.5	0.6	0.8	-0.8	0.5	-0.9
Pulse wave reflection index	0.5	0.6	1.0	0.1	0.9	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.6	1.2	0.4	0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.3	1.5	0.3	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	-0.1	0.4	-1.2
Health satisfaction	0.5	0.6	1.0	-0.5	-1.0	0.8
Angina (self-reported)	0.5	0.7	2.1	-0.0	1.4	-0.2
Alcohol intake frequency.	0.5	1.1	2.0	-1.0	-1.4	0.6
Number of full sisters	0.5	0.6	1.0	1.0	0.2	0.9
Chest pain or discomfort	0.5	0.8	1.5	0.9	1.2	-0.1
Hypertension (Self-reported)	0.5	1.3	3.8	-2.0	0.3	-0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.1	-1.0	-1.0	0.1
Irritability	0.5	0.8	1.3	-1.0	-1.1	-0.5
Cholesterol lowering medication	0.5	0.7	1.6	-1.2	-0.4	-0.7
Alzheimer’s Disease (including proxy)	0.4	0.5	1.0	1.0	0.5	-0.5
Reaction Time	0.4	0.9	1.9	0.7	-1.4	0.2
Age at First Birth	0.4	0.6	1.7	1.3	-0.2	-0.0
Blood Eosinophil Count	0.4	3.4	5.3	-2.3	-1.9	1.0
Systolic Blood Pressure	0.4	2.2	6.4	-0.3	2.5	-0.3
Hypothyroidism (self reported)	0.4	0.9	2.0	-1.4	-0.9	0.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.2	0.4	-1.1	-0.7
Severe depression (siblings)	0.4	0.4	0.8	0.6	0.9	-0.5
High blood pressure	0.4	1.1	3.0	-1.7	-0.2	-0.4
Sitting height	0.4	3.2	8.4	0.9	2.9	0.5
Chronic bronchitis/emphysema (father)	0.4	0.4	0.9	0.6	-0.9	0.1
Past tobacco smoking	0.4	0.7	0.8	-0.6	-0.9	-0.9
Qualifications: None of the above	0.4	1.0	1.8	-0.6	-0.8	-1.4
Arm fat percentage (right)	0.4	1.5	2.7	-1.3	0.5	1.6
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.5	-0.3	0.1	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.9	-0.1	-1.0	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	-0.4	0.7	-1.1
Pulse wave peak to peak time	0.4	0.4	0.5	0.6	0.7	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.8	0.5	-0.6	-0.9
Emphysema/chronic bronchitis	0.4	0.4	1.1	-0.3	-1.1	-0.0
Medication for pain relief, constipation, heartburn	0.4	0.7	1.2	1.1	0.4	0.9
Arm fat percentage (left)	0.4	1.6	2.7	-1.4	0.4	1.6
Average weekly red wine intake	0.4	0.6	1.4	1.2	0.6	-0.2
Hearing aid user	0.4	0.5	1.0	0.7	-0.2	-1.0
High cholesterol (Self-reported)	0.4	0.8	2.2	-1.5	0.1	-0.4
Medication: Bendroflumethiazide	0.4	0.6	0.9	-1.0	-0.9	-0.0
Vascular/heart problems diagnosed by doctor	0.4	1.2	3.0	1.7	-0.2	0.7
Depression (Nagel 2018)	0.3	0.4	0.6	0.5	-0.7	-0.8
HDL Cholesterol	0.3	0.5	1.2	0.6	1.1	-0.1
Primary Biliary Cirrhosis	0.3	0.4	0.6	-0.0	0.8	-0.7
Relative age of first facial hair	0.3	0.5	1.0	0.7	-0.4	1.0
Trunk fat percentage	0.3	1.3	2.4	-0.4	1.1	1.6
Average weekly fortified wine intake	0.3	0.4	0.5	-0.7	0.5	-0.7
Supplements: Glucosamine	0.3	0.4	0.6	0.7	0.7	0.4
Pulse wave Arterial Stiffness index	0.3	0.3	0.3	-0.5	-0.6	0.6
Standing height	0.3	2.8	8.2	0.4	2.9	0.5
Birth weight of first child	0.3	0.6	1.7	-1.3	0.3	-0.3
Gout (self-reported)	0.3	0.4	0.8	-0.9	-0.6	-0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.2	-1.1	-0.7	0.2
Body fat percentage	0.3	1.1	2.0	-1.2	0.2	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.2	0.0	1.1	0.0
Number of children fathered	0.3	0.3	0.5	-0.2	-0.6	-0.7
Pulse rate, automated reading	0.3	1.1	1.5	-1.2	-0.7	1.2
Illnesses of siblings: Diabetes	0.3	0.4	0.8	-0.5	0.2	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.6	-0.7	0.4
Qualifications: nursing, teaching	0.3	0.5	1.1	0.1	0.7	1.0
Mineral and other dietary supplements	0.3	0.4	0.9	1.0	-0.4	0.1
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	0.1	-0.9	-0.5
Miserableness	0.3	0.5	1.3	-1.1	0.1	0.5
Medication: Atorvastatin	0.3	0.4	1.0	-0.6	1.0	0.2
Fractured/broken bones in last 5 years	0.3	0.4	1.0	0.5	1.0	-0.1
Age started oral contraceptive pill	0.3	0.3	0.6	-0.6	-0.8	0.1
Myopia	0.3	0.5	0.7	-0.8	0.5	-0.7
Pain experienced in last month	0.3	0.5	0.7	-0.9	-0.6	-0.7
Neuroticism (Nagel 2018)	0.2	0.5	0.7	-0.8	-0.8	-0.4
Alzheimer’s Disease (in mother)	0.2	0.3	0.4	0.5	-0.6	-0.4
Lupus	0.2	0.3	0.8	-0.9	-0.1	-0.2
Waist Hip Ratio (WHR)	0.2	0.9	1.0	-0.9	-1.0	-0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.0	-1.0	0.4	-0.3
Neuroticism	0.2	0.5	1.2	0.2	-0.5	-1.1
Chronotype (morning person)	0.2	0.6	0.9	-0.9	0.2	-1.0
Tanning	0.2	2.8	4.3	1.1	-2.1	-1.7
Sensitivity / hurt feelings	0.2	0.4	0.7	0.5	0.4	0.8
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.2	-0.9	-0.1
Systolic blood pressure, automated reading	0.2	0.6	1.4	-0.5	1.2	0.3
Vitamin and mineral supplements	0.2	0.2	0.5	0.0	-0.4	0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	0.2	-0.0	-0.7
Nervous feelings	0.2	0.3	0.5	-0.3	-0.6	-0.7
Mouth/teeth dental problems	0.2	0.3	0.6	-0.8	0.5	-0.3
Pain all over the body in last month	0.2	0.3	0.4	-0.3	0.5	0.7
Mouth/teeth dental problems: Dentures	0.2	0.4	0.7	-0.6	-0.8	-0.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.3	0.7	-0.0
Headache pain in last month	0.2	0.3	0.6	-0.8	0.6	-0.2
Glaucoma (self-reported)	0.2	0.3	0.4	-0.3	0.7	0.5
Medication: Amlodipine	0.2	0.2	0.6	-0.2	-0.1	-0.8
High blood pressure (siblings)	0.2	0.3	0.9	0.1	1.0	-0.1
Medication: Blood pressure	0.2	0.4	0.6	-0.8	-0.2	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	-0.6	0.1	0.6
Comparative height size at age 10	0.2	1.0	2.5	-1.6	0.6	0.3
Suffer from ‘nerves’	0.2	0.3	0.6	-0.5	-0.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	-0.2	0.5	0.5
Illnesses of father: Heart disease	0.2	0.3	0.5	0.7	0.4	-0.3
Smoking status: Previous	0.2	0.2	0.7	0.0	0.8	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.0	-0.5	0.8
Back pain experienced in last month	0.2	0.4	0.6	-0.6	-0.8	-0.3
Ever depressed for a whole week	0.2	0.2	0.6	-0.3	0.8	0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	-0.2	0.8	0.0
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	-0.6	-0.6	0.2
Height	0.1	1.3	3.8	-0.4	1.9	0.2
Smoking Status	0.1	0.2	0.5	0.7	0.5	0.0
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.5	0.4	-0.0
Supplements: Zinc	0.1	0.1	0.2	0.2	-0.4	-0.2
Fed-up feelings	0.1	0.3	0.7	0.8	0.2	0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.4	0.5	0.3
Medication: Atenolol	0.1	0.1	0.4	0.1	-0.6	-0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.4	-0.1	-0.3	0.6
Heart attack	0.1	0.2	0.5	-0.1	0.7	0.0
Neuroticism score	0.1	0.2	0.5	-0.0	-0.1	-0.7
Medication: Cholesterol lowering	0.1	0.2	0.3	-0.6	0.5	0.2
Lung cancer (father)	0.1	0.1	0.3	0.0	0.5	-0.2
Medication: Paracetamol	0.1	0.1	0.2	-0.1	-0.3	-0.4
Birth weight	0.1	0.1	0.2	0.3	-0.5	0.2
Worry too long after embarrassment	0.1	0.1	0.1	-0.4	-0.3	0.2
Age at first live birth	0.1	0.2	0.4	-0.1	0.4	0.6
Neck or shoulder pain in last month	0.1	0.2	0.3	0.6	0.3	-0.2
Migraine (self-reported)	0.1	0.1	0.2	-0.2	0.4	0.5
Medication: Ibuprofen	0.1	0.1	0.3	-0.2	-0.0	0.5
Medication: Allopurinol	0.1	0.1	0.3	-0.3	-0.5	0.2
Knee pain experienced in last month	0.1	0.1	0.2	0.2	0.0	0.5
Loneliness, isolation	0.1	0.1	0.2	-0.4	-0.2	-0.3
Breast cancer (self-reported)	0.1	0.1	0.2	-0.4	-0.1	-0.4
Smoking status: Current	0.1	0.2	0.3	0.2	-0.3	0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.1	-0.3	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	-0.1	0.5	0.4
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.4	0.2	-0.3
Diastolic blood pressure, automated reading	0.1	0.2	0.5	-0.7	0.4	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.2	0.6	0.7	0.3	-0.1
Hair Pigment	0.0	1.2	2.1	-1.2	0.3	1.4
Current tobacco smoking	0.0	0.1	0.2	0.1	-0.1	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	-0.2	0.3	-0.1
Breastfed as a baby	0.0	0.0	0.0	-0.1	0.0	-0.1
Number of full brothers	0.0	0.0	0.0	-0.2	-0.1	-0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	0.0	0.4	0.1
Family relationship satisfaction	0.0	0.0	0.1	-0.1	0.1	0.3
Alcohol drinker status: Previous	0.0	0.0	0.1	0.0	0.1	-0.3

Hub : Genes

CAPN10-AS1

Models

Trait associations